Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6173020	6173020	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:6173020G>A	uc001amb.1	-	34	5051	c.4951C>T	c.(4951-4953)CTG>TTG	p.L1651L	CHD5_uc001alz.1_Silent_p.L508L|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1651					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTCAGCTCCAGCTTGTCCAGG	0.577			NA											3	31					0	0	0.004672	0	0
CAMTA1	23261	broad.mit.edu	37	1	7700548	7700548	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:7700548A>G	uc001aoi.2	+	7	806	c.599A>G	c.(598-600)AAC>AGC	p.N200S		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TGCTCCATCAACACCGACAAG	0.627			NA											5	95					0	0	0.001168	0	0
PTCHD2	57540	broad.mit.edu	37	1	11574545	11574545	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:11574545G>A	uc001ash.3	+	4	1553	c.1415G>A	c.(1414-1416)TGC>TAC	p.C472Y	PTCHD2_uc001asi.1_Missense_Mutation_p.C472Y	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	472	SSD.|Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGCAGCAGCTGCATTGCTGCC	0.582			NA											4	81					0	0	0.009096	0	0
TNFRSF8	943	broad.mit.edu	37	1	12157231	12157231	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:12157231G>T	uc001atq.2	+	3	447	c.225G>T	c.(223-225)CTG>CTT	p.L75L	TNFRSF8_uc010obc.1_5'UTR	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	75	Extracellular (Potential).|TNFR-Cys 2.				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		ACTACTACCTGGATGAGGCCG	0.577			NA											46	111					6.23363e-37	1.02471e-36	0.00361	1	0
PRAMEF18	391003	broad.mit.edu	37	1	13474988	13474988	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:13474988T>C	uc009vnu.1	-	3	1188	c.1141A>G	c.(1141-1143)ACT>GCT	p.T381A		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	381											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCAGAAAGTGGTGAGGTTG	0.562			NA											30	280					0	0	0.00361	0	0
HP1BP3	50809	broad.mit.edu	37	1	21074085	21074086	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:21074085_21074086CC>AA	uc001bdw.1	-	11	1344_1345	c.1204_1205GG>TT	c.(1204-1206)GGG>TTG	p.G402L	HP1BP3_uc001bdv.1_Missense_Mutation_p.G364L|HP1BP3_uc010odh.1_Missense_Mutation_p.G364L|HP1BP3_uc001bdy.1_Missense_Mutation_p.G402L|HP1BP3_uc010odf.1_Missense_Mutation_p.G61L|HP1BP3_uc010odg.1_Missense_Mutation_p.G250L	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	402	H15 3.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GAACCCTTTCCCAGAGATCTGT	0.371			NA											17	79					0	0	0.004672	0	0
ZBTB40	9923	broad.mit.edu	37	1	22817990	22817990	+	Silent	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:22817990A>G	uc001bft.2	+	4	1306	c.795A>G	c.(793-795)CTA>CTG	p.L265L	ZBTB40_uc001bfu.2_Silent_p.L265L|ZBTB40_uc009vqi.1_Silent_p.L265L	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	265					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TAAAAAAACTAGAAATGTGTT	0.378			NA											69	182					0	0	0.00361	0	0
C1QB	713	broad.mit.edu	37	1	22986096	22986096	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:22986096C>A	uc001bgd.2	+	2	279	c.147C>A	c.(145-147)CCC>CCA	p.P49P		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	49	Collagen-like 1.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CACCTGGCCCCGATGGCCAAC	0.602			NA											26	60					1.06801e-11	1.34122e-11	0.009535	1	0
MYOM3	127294	broad.mit.edu	37	1	24388533	24388533	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:24388533G>A	uc001bin.3	-	33	4000	c.3837C>T	c.(3835-3837)CAC>CAT	p.H1279H	MYOM3_uc001bil.3_Silent_p.H172H|MYOM3_uc001bim.3_Silent_p.H936H	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1279										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGTCCAGGATGTGAAGCCAGA	0.532			NA											51	406					0	0	0.00361	0	0
MYOM3	127294	broad.mit.edu	37	1	24421441	24421441	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:24421441A>T	uc001bin.3	-	9	993	c.830T>A	c.(829-831)CTG>CAG	p.L277Q	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.L277Q|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	277	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GACTGGCTTCAGCACCGAGGT	0.537			NA											32	45					0	0	0.002522	0	0
NIPAL3	57185	broad.mit.edu	37	1	24785406	24785406	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:24785406G>T	uc001bjh.2	+	9	1209	c.802G>T	c.(802-804)GAC>TAC	p.D268Y	NIPAL3_uc001bjg.2_Missense_Mutation_p.D268Y|NIPAL3_uc009vrc.2_Missense_Mutation_p.D186Y|NIPAL3_uc001bji.2_Missense_Mutation_p.R76L	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	268						integral to membrane					0						ACAGATGTACGACTCCTCTTT	0.468			NA											59	233					6.88731e-43	1.16954e-42	0.00361	1	0
ZNF683	257101	broad.mit.edu	37	1	26688465	26688465	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:26688465G>C	uc001bmg.1	-	7	1370	c.1252C>G	c.(1252-1254)CGC>GGC	p.R418G	ZNF683_uc001bmh.1_Missense_Mutation_p.R398G|ZNF683_uc009vsj.1_Missense_Mutation_p.R398G	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	418	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GAGTGCAGGCGCAGGTGGGTC	0.637			NA											10	33					0	0	0.001855	0	0
PTAFR	5724	broad.mit.edu	37	1	28476668	28476668	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:28476668C>A	uc001bpl.2	-	2	992	c.865G>T	c.(865-867)GAC>TAC	p.D289Y	PTAFR_uc001bpm.3_Missense_Mutation_p.D289Y|PTAFR_uc009vte.2_Missense_Mutation_p.D289Y	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	289	Helical; Name=7; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		ATAACAGGGTCTAAGACACAG	0.537			NA											15	110					1.99824e-07	2.31307e-07	0.00499	1	0
GMEB1	10691	broad.mit.edu	37	1	29041146	29041146	+	Missense_Mutation	SNP	C	C	T	rs148243859		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:29041146C>T	uc001bra.2	+	10	1721	c.1583C>T	c.(1582-1584)CCG>CTG	p.P528L	GMEB1_uc001bqz.2_Missense_Mutation_p.P518L|GMEB1_uc001brb.2_Missense_Mutation_p.P518L	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GATCCAGCCCCGGACCCAGAA	0.532			NA											9	112					0	0	0.008291	0	0
YTHDF2	51441	broad.mit.edu	37	1	29070324	29070324	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:29070324C>G	uc001brc.2	+	4	2039	c.1542C>G	c.(1540-1542)CGC>CGG	p.R514R	YTHDF2_uc001brd.2_Silent_p.R511R|YTHDF2_uc010ofx.1_Silent_p.R464R|YTHDF2_uc001bre.2_Silent_p.R464R	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	514	YTH.				humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GACACATTCGCCTAGAGAACA	0.478			NA											10	95					0	0	0.000978	0	0
CSMD2	114784	broad.mit.edu	37	1	34006151	34006151	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:34006151C>A	uc001bxn.1	-	59	9202	c.9173G>T	c.(9172-9174)TGG>TTG	p.W3058L	CSMD2_uc001bxm.1_Missense_Mutation_p.W3202L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3058	Sushi 23.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCTCCGGTCCAGGACCCATT	0.577			NA											13	161					1.49906e-05	1.6725e-05	0.00245	1	0
CSMD2	114784	broad.mit.edu	37	1	34209016	34209016	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:34209016C>A	uc001bxn.1	-	14	1947	c.1918G>T	c.(1918-1920)GCC>TCC	p.A640S	CSMD2_uc001bxm.1_Missense_Mutation_p.A680S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	640	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCGCCTCGGCGGTGGCCCCA	0.617			NA											13	80					4.14922e-12	5.27816e-12	0.004007	1	0
ZMYM4	9202	broad.mit.edu	37	1	35847281	35847281	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:35847281G>T	uc001byt.2	+	9	1571	c.1491G>T	c.(1489-1491)TCG>TCT	p.S497S	ZMYM4_uc009vuu.2_Silent_p.S465S|ZMYM4_uc001byu.2_Silent_p.S173S|ZMYM4_uc009vuv.2_Silent_p.S236S	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	497	MYM-type 3.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACAGTGGGTCGGGACAATGCC	0.433			NA											35	317					4.14481e-20	5.93686e-20	0.00623	1	0
EIF2C3	192669	broad.mit.edu	37	1	36437711	36437711	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:36437711G>T	uc001bzp.2	+	4	655	c.399G>T	c.(397-399)TGG>TGT	p.W133C	EIF2C3_uc001bzn.1_Missense_Mutation_p.W133C|EIF2C3_uc001bzo.2_RNA|EIF2C3_uc001bzq.2_5'UTR	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	133					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGGTGAGTTGGCACCTACTGC	0.483	Colon(144;60 2363 31043 40539)		NA											30	184					9.78485e-24	1.45962e-23	0.002836	1	0
SNIP1	79753	broad.mit.edu	37	1	38005774	38005774	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:38005774C>A	uc001cbi.2	-	3	983	c.910G>T	c.(910-912)GCG>TCG	p.A304S	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	304	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				TGAAAGACCGCATGCTGCTTT	0.428			NA											61	522					1.15098e-32	1.83612e-32	0.00361	1	0
WDR65	149465	broad.mit.edu	37	1	43638557	43638557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:43638557C>A	uc001cip.1	+	2	254	c.133C>A	c.(133-135)CAG>AAG	p.Q45K	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Silent_p.I3I|WDR65_uc001ciq.1_Missense_Mutation_p.Q45K|EBNA1BP2_uc001cim.2_5'Flank|EBNA1BP2_uc001cin.2_5'Flank|EBNA1BP2_uc010ojx.1_5'Flank|EBNA1BP2_uc010ojy.1_5'Flank	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	45										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAATGTGGATCAGAAATGGCA	0.313			NA											53	176					2.19297e-23	3.26676e-23	0.00361	1	0
KIAA0467	23334	broad.mit.edu	37	1	43909130	43909130	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:43909130T>C	uc001cjk.1	+	46	6372	c.5910T>C	c.(5908-5910)TCT>TCC	p.S1970S	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2869						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGAGACCTCTGGACCCCCTG	0.612			NA											7	24					0	0	0.00308	0	0
PTPRF	5792	broad.mit.edu	37	1	44084819	44084819	+	Missense_Mutation	SNP	G	G	A	rs70937045		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:44084819G>A	uc001cjr.2	+	27	4932	c.4592G>A	c.(4591-4593)CGA>CAA	p.R1531Q	PTPRF_uc001cjs.2_Missense_Mutation_p.R1522Q|PTPRF_uc001cju.2_Missense_Mutation_p.R920Q|PTPRF_uc009vwt.2_Missense_Mutation_p.R1091Q|PTPRF_uc001cjv.2_Missense_Mutation_p.R1002Q|PTPRF_uc001cjw.2_Missense_Mutation_p.R757Q	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1531	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCTTCCTACGACGGGTCAAG	0.627			NA											7	29					0	0	0.001984	0	0
KDM4A	9682	broad.mit.edu	37	1	44137514	44137514	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:44137514G>A	uc001cjx.2	+	11	1868	c.1702G>A	c.(1702-1704)GCT>ACT	p.A568T	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	568					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						AGGAAGCGCCGCTAGAAGTTT	0.612			NA											6	187					0	0	0.001984	0	0
FAF1	11124	broad.mit.edu	37	1	50941174	50941174	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:50941174C>A	uc009vyx.1	-	19	1894	c.1831G>T	c.(1831-1833)GAT>TAT	p.D611Y	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Missense_Mutation_p.D611Y|FAF1_uc010onc.1_Missense_Mutation_p.D369Y	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	611	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TTGTACTCATCCCATGGAAAT	0.488			NA											12	581					5.35267e-07	6.16956e-07	0.007413	1	0
TXNDC12	51060	broad.mit.edu	37	1	52486661	52486661	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:52486661G>A	uc001cti.2	-	7	742	c.463C>T	c.(463-465)CAG>TAG	p.Q155*		NM_015913	NP_056997	O95831	AIFM1_HUMAN	thioredoxin domain containing 12 precursor	Error:Variant_position_missing_in_O95831_after_alignment					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding	p.Q155L(1)		ovary(1)	1						AGCCTTTCCTGAGCTTCCTTC	0.383			NA											46	310					0	0	0.00361	0	0
C8B	732	broad.mit.edu	37	1	57409484	57409484	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:57409484G>T	uc001cyp.2	-	8	1186	c.1119C>A	c.(1117-1119)AAC>AAA	p.N373K	C8B_uc010oon.1_Missense_Mutation_p.N311K|C8B_uc010ooo.1_Missense_Mutation_p.N321K	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	373	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CATGGACGTTGTTAAGAGTAT	0.438			NA											52	296					4.63999e-43	7.89163e-43	0.00361	1	0
INSL5	10022	broad.mit.edu	37	1	67266839	67266839	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:67266839G>T	uc001dcw.2	-	1	101	c.66C>A	c.(64-66)AGC>AGA	p.S22R		NM_005478	NP_005469	Q9Y5Q6	INSL5_HUMAN	insulin-like 5 precursor	22						extracellular region	hormone activity				0						CAGACTCCTTGCTCCGCACTT	0.463			NA											74	148					4.38691e-48	7.64171e-48	0.00361	1	0
LRRC7	57554	broad.mit.edu	37	1	70504811	70504811	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:70504811A>G	uc001dep.2	+	19	3220	c.3190A>G	c.(3190-3192)AAA>GAA	p.K1064E	LRRC7_uc009wbg.2_Missense_Mutation_p.K348E|LRRC7_uc001deq.2_Missense_Mutation_p.K305E	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1064						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ACAGGCCAGCAAAAACATCGC	0.463			NA											20	54					0	0	0.010504	0	0
NEGR1	257194	broad.mit.edu	37	1	72400910	72400910	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:72400910C>A	uc001dfw.2	-	2	361	c.261G>T	c.(259-261)GTG>GTT	p.V87V	NEGR1_uc001dfv.2_5'UTR|NEGR1_uc010oqs.1_Silent_p.V87V	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	87	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		CTCGAGGATCCACTGACCACT	0.433			NA											24	85					3.6726e-16	4.98293e-16	0.003954	1	0
C1orf173	127254	broad.mit.edu	37	1	75042610	75042610	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:75042610T>A	uc001dgg.2	-	13	2406	c.2187A>T	c.(2185-2187)TCA>TCT	p.S729S	uc001dgh.2_5'Flank	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	729	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTAATGGCAATGAATCCTTTC	0.378			NA											6	188					0	0	0.001168	0	0
C1orf173	127254	broad.mit.edu	37	1	75097613	75097613	+	Splice_Site	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:75097613C>G	uc001dgg.2	-	7	823	c.604_splice	c.e7-1	p.G202_splice	C1orf173_uc001dgi.3_Splice_Site	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254											ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCTTGCCCTGTAATCATA	0.368			NA											21	407					0	0	0.00278	0	0
PTGFR	5737	broad.mit.edu	37	1	78959150	78959150	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:78959150G>C	uc001din.2	+	2	988	c.722G>C	c.(721-723)AGA>ACA	p.R241T	PTGFR_uc001dim.2_Missense_Mutation_p.R241T	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	241	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	AGACAAGGCAGATCTCATCAT	0.423			NA											22	98					0	0	0.00632	0	0
ELTD1	64123	broad.mit.edu	37	1	79402013	79402013	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:79402013A>T	uc001diq.3	-	7	1000	c.844T>A	c.(844-846)TTT>ATT	p.F282I		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	282	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTCTTTGGAAATATATTTATG	0.279			NA											29	232					0	0	0.005524	0	0
GBP1	2633	broad.mit.edu	37	1	89523812	89523812	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:89523812T>G	uc001dmx.2	-	6	957	c.737A>C	c.(736-738)AAG>ACG	p.K246T		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	246					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		CTGGGCAAGCTTCCTGCGGTG	0.433			NA											8	233					0	0	0.001368	0	0
TGFBR3	7049	broad.mit.edu	37	1	92174229	92174229	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:92174229C>A	uc001doh.2	-	14	2744	c.2278G>T	c.(2278-2280)GAA>TAA	p.E760*	TGFBR3_uc009wde.2_Nonsense_Mutation_p.E455*|TGFBR3_uc010osy.1_Nonsense_Mutation_p.E718*|TGFBR3_uc001doi.2_Nonsense_Mutation_p.E759*|TGFBR3_uc001doj.2_Nonsense_Mutation_p.E759*	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	760	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CCTTTAGATTCTGCTTCATGG	0.493			NA											56	237					1.73933e-33	2.78706e-33	0.00361	1	0
ABCA4	24	broad.mit.edu	37	1	94574149	94574149	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:94574149G>T	uc001dqh.2	-	4	530	c.426C>A	c.(424-426)CAC>CAA	p.H142Q	ABCA4_uc010otn.1_Missense_Mutation_p.H142Q	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	142	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTCTCTCCGGGTGAGTCCGGA	0.408			NA											52	138					9.77497e-20	1.39458e-19	0.00361	1	0
LPPR4	9890	broad.mit.edu	37	1	99767413	99767413	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:99767413A>C	uc001dse.2	+	6	1032	c.926A>C	c.(925-927)TAT>TCT	p.Y309S	LPPR4_uc010oue.1_Intron	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	309	Helical; (Potential).						phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GTTGATGTCTATTGTGGCTTT	0.358			NA											17	167					0	0	0.007413	0	0
AGL	178	broad.mit.edu	37	1	100336081	100336081	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:100336081G>T	uc001dsi.1	+	6	1190	c.790G>T	c.(790-792)GGG>TGG	p.G264W	AGL_uc001dsj.1_Missense_Mutation_p.G264W|AGL_uc001dsk.1_Missense_Mutation_p.G264W|AGL_uc001dsl.1_Missense_Mutation_p.G264W|AGL_uc001dsm.1_Missense_Mutation_p.G248W|AGL_uc001dsn.1_Missense_Mutation_p.G247W	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	264	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TGTTGCAGAAGGGAAATACAA	0.383			NA											35	123					1.41504e-22	2.08776e-22	0.002852	1	0
COL11A1	1301	broad.mit.edu	37	1	103347308	103347308	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:103347308G>T	uc001dul.2	-	65	5303	c.4985C>A	c.(4984-4986)TCA>TAA	p.S1662*	COL11A1_uc001duk.2_Nonsense_Mutation_p.S858*|COL11A1_uc001dum.2_Nonsense_Mutation_p.S1674*|COL11A1_uc001dun.2_Nonsense_Mutation_p.S1623*|COL11A1_uc009weh.2_Nonsense_Mutation_p.S1546*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1662	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTTGGCCATGATGAAATTCT	0.318			NA											10	86					9.31168e-06	1.04756e-05	0.001855	1	0
PRPF38B	55119	broad.mit.edu	37	1	109241225	109241225	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:109241225G>T	uc001dvv.3	+	5	841	c.559_splice	c.e5-1	p.D187_splice	PRPF38B_uc001dvw.3_Splice_Site_p.D76_splice|PRPF38B_uc010ouz.1_Splice_Site	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)						mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		TGTTTCTGTAGGACCTAGATG	0.353			NA											50	96					4.6707e-30	7.37479e-30	0.00361	1	0
SYT6	148281	broad.mit.edu	37	1	114640465	114640465	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:114640465C>A	uc001eev.2	-	6	1394	c.1144G>T	c.(1144-1146)GTG>TTG	p.V382L	SYT6_uc001eeu.2_Missense_Mutation_p.V27L	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	467	Cytoplasmic (Potential).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGATCCCCACACGACAGACT	0.567			NA											33	216					2.52637e-11	3.15797e-11	0.005524	1	0
PTGFRN	5738	broad.mit.edu	37	1	117509740	117509740	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:117509740T>C	uc001egv.1	+	6	1984	c.1847T>C	c.(1846-1848)CTG>CCG	p.L616P		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	616	Ig-like C2-type 5.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GTGGTGAAGCTGGAGAATTGG	0.498			NA											50	649					0	0	0.00361	0	0
WARS2	10352	broad.mit.edu	37	1	119619185	119619185	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:119619185T>C	uc001ehn.2	-	2	164	c.136A>G	c.(136-138)ATC>GTC	p.I46V	WARS2_uc010oxf.1_5'UTR|WARS2_uc001ehm.2_Missense_Mutation_p.I46V|WARS2_uc010oxg.1_Missense_Mutation_p.I46V|WARS2_uc010oxh.1_Missense_Mutation_p.I46V|WARS2_uc010oxi.1_5'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	46					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AGGTGGAGGATTCCTGTAGGT	0.448			NA											59	511					0	0	0.00361	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144863409	144863409	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:144863409C>A	uc001elw.3	-	37	6285	c.5994G>T	c.(5992-5994)CAG>CAT	p.Q1998H	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.Q1892H|PDE4DIP_uc001elv.3_Missense_Mutation_p.Q1005H|PDE4DIP_uc001ema.2_3'UTR	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1998	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTCTTCACACTGTTGCTGCA	0.522			NA	T	PDGFRB	MPD								9	515					1.3612e-06	1.55074e-06	0.003163	1	0
PIP5K1A	8394	broad.mit.edu	37	1	151204252	151204252	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:151204252G>T	uc001exj.2	+	5	795	c.343G>T	c.(343-345)GTG>TTG	p.V115L	PIP5K1A_uc001exi.2_Missense_Mutation_p.V102L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.V103L|PIP5K1A_uc001exk.2_Missense_Mutation_p.V102L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	115	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGATTTCTACGTGGTTGAGAG	0.488	Pancreas(80;36 1443 2325 16095 21302)		NA											103	290					1.4093e-69	2.62876e-69	0.00361	1	0
PI4KB	5298	broad.mit.edu	37	1	151288658	151288658	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:151288658C>A	uc001ext.2	-	2	715	c.300G>T	c.(298-300)GAG>GAT	p.E100D	PI4KB_uc001exr.2_Missense_Mutation_p.E112D|PI4KB_uc001exs.2_Missense_Mutation_p.E100D|PI4KB_uc001exu.2_Missense_Mutation_p.E100D|PI4KB_uc010pcw.1_Intron|PI4KB_uc009wmq.1_Missense_Mutation_p.E112D	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	100					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTCATCTTCCTCCTCCCTGA	0.577	Colon(154;765 1838 9854 28443 37492)		NA											47	224					5.66675e-16	7.66929e-16	0.00361	1	0
THEM4	117145	broad.mit.edu	37	1	151849531	151849531	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:151849531C>T	uc001ezj.1	-	5	807	c.628G>A	c.(628-630)GTT>ATT	p.V210I	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	210					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTACAGGAAACAAAAAATTTC	0.368			NA											6	271					0	0	0.001984	0	0
FLG	2312	broad.mit.edu	37	1	152285480	152285480	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:152285480G>C	uc001ezu.1	-	3	1918	c.1882C>G	c.(1882-1884)CAG>GAG	p.Q628E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	628	Filaggrin 3.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTGTCCCTGACTGTCACTG	0.567			NA							Ichthyosis				104	230					0	0	0.00361	0	0
LCE3D	84648	broad.mit.edu	37	1	152552354	152552354	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:152552354T>A	uc001fab.2	-	2	116	c.59A>T	c.(58-60)AAG>ATG	p.K20M		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	20					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		TGGGGGACACTTGGGTGAGGG	0.602			NA											55	183					0	0	0.00361	0	0
LCE3D	84648	broad.mit.edu	37	1	152552359	152552359	+	Silent	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:152552359T>G	uc001fab.2	-	2	111	c.54A>C	c.(52-54)TCA>TCC	p.S18S		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	18					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GACACTTGGGTGAGGGACACT	0.597			NA											55	191					0	0	0.00361	0	0
LCE3D	84648	broad.mit.edu	37	1	152552407	152552407	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:152552407G>T	uc001fab.2	-	2	63	c.6C>A	c.(4-6)TCC>TCA	p.S2S		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	2					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		TCTGCTGGCAGGACATCTTGG	0.547			NA											40	203					6.31075e-24	9.4399e-24	0.00361	1	0
LCE4A	199834	broad.mit.edu	37	1	152681629	152681629	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:152681629C>T	uc001fak.2	+	1	107	c.78C>T	c.(76-78)CCC>CCT	p.P26P		NM_178356	NP_848133	Q5TA78	LCE4A_HUMAN	late cornified envelope 4A	26	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)			CAAAATGTCCCTCAAAGTGTG	0.572			NA											49	305					0	0	0.00361	0	0
SPRR1B	6699	broad.mit.edu	37	1	153005016	153005016	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:153005016C>A	uc001fba.2	+	2	259	c.195C>A	c.(193-195)TGC>TGA	p.C65*	SPRR1B_uc009wnx.1_Intron	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	65	5.|6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAGCCATGCCACCCCAAGG	0.617			NA											99	358					5.93169e-28	9.19114e-28	0.00361	1	0
SPRR2E	6704	broad.mit.edu	37	1	153066043	153066043	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:153066043G>T	uc001fbh.2	-	2	246	c.185C>A	c.(184-186)CCC>CAC	p.P62H	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001024209	NP_001019380	P22531	SPR2E_HUMAN	small proline-rich protein 2E	62					keratinization	cornified envelope|cytoplasm	protein binding|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGCTGGCAGGGTGGGGAAGG	0.552			NA											184	656					1.01623e-67	1.88904e-67	0.00361	1	0
LELP1	149018	broad.mit.edu	37	1	153177368	153177368	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:153177368C>A	uc001fbl.2	+	2	295	c.185C>A	c.(184-186)CCC>CAC	p.P62H		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	62	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGCCCTGCCCCTCGCAGTCT	0.592			NA											17	237					1.48734e-19	2.11916e-19	0.003214	1	0
FCRL4	83417	broad.mit.edu	37	1	157556176	157556176	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:157556176A>T	uc001fqw.2	-	6	1053	c.917T>A	c.(916-918)CTG>CAG	p.L306Q	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	306	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GACAAGGACCAGCATCTCCCC	0.602			NA											64	176					0	0	0.00361	0	0
CD5L	922	broad.mit.edu	37	1	157803126	157803126	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:157803126T>A	uc001frk.3	-	5	1038	c.895A>T	c.(895-897)AAA>TAA	p.K299*		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	299	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCATAGCATTTCCGGTCTCTG	0.577			NA											66	183					0	0	0.00361	0	0
OR6K2	81448	broad.mit.edu	37	1	158670253	158670253	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:158670253T>A	uc001fsu.1	-	1	190	c.190A>T	c.(190-192)AGT>TGT	p.S64C		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GAAAGAGCACTGATAAAAGTA	0.438			NA											156	386					0	0	0.00361	0	0
OR6K3	391114	broad.mit.edu	37	1	158687393	158687393	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:158687393G>T	uc010pip.1	-	1	561	c.561C>A	c.(559-561)CCC>CCA	p.P187P		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GGATTTGGTTGGGCCCACAGA	0.512			NA											184	474					3.16392e-82	5.98431e-82	0.00361	1	0
MNDA	4332	broad.mit.edu	37	1	158815548	158815548	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:158815548C>A	uc001fsz.1	+	5	942	c.742C>A	c.(742-744)CAT>AAT	p.H248N		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	248	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TCAATATTTCCATGTGAAAGT	0.378			NA											51	149					1.40541e-12	1.8048e-12	0.00361	1	0
CD244	51744	broad.mit.edu	37	1	160808305	160808305	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:160808305G>T	uc009wtq.2	-	5	963	c.785C>A	c.(784-786)ACC>AAC	p.T262N	CD244_uc001fxa.2_Missense_Mutation_p.T257N|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.T165N	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	262	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTTGGGACTGGTCTCTGAGGG	0.488			NA											54	142					1.41401e-22	2.08776e-22	0.00361	1	0
CD244	51744	broad.mit.edu	37	1	160811267	160811267	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:160811267C>A	uc009wtq.2	-	3	581	c.403G>T	c.(403-405)GAG>TAG	p.E135*	CD244_uc001fxa.2_Nonsense_Mutation_p.E130*|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Intron|CD244_uc010pjt.1_Intron	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	135	Extracellular (Potential).|Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CGGGGTTTCTCAACTTTATCT	0.507			NA											21	111					3.62473e-10	4.41343e-10	0.001882	1	0
FCRLA	84824	broad.mit.edu	37	1	161680653	161680653	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:161680653G>A	uc001gbe.2	+	3	494	c.252G>A	c.(250-252)CAG>CAA	p.Q84Q	FCRLA_uc001gbd.2_Silent_p.Q78Q|FCRLA_uc001gbf.2_Silent_p.Q78Q|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Silent_p.Q78Q|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	61					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CTGGCTTCCAGGTCAAGGCCT	0.562			NA											40	123					0	0	0.009718	0	0
FCRLA	84824	broad.mit.edu	37	1	161680697	161680698	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:161680697_161680698CC>AA	uc001gbe.2	+	3	538_539	c.296_297CC>AA	c.(295-297)TCC>TAA	p.S99*	FCRLA_uc001gbd.2_Nonsense_Mutation_p.S93*|FCRLA_uc001gbf.2_Nonsense_Mutation_p.S93*|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Nonsense_Mutation_p.S93*|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	76	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CTGATTGTGTCCTATGGTGAGG	0.554			NA											43	117					0	0	0.004672	0	0
NOS1AP	9722	broad.mit.edu	37	1	162336927	162336927	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:162336927G>T	uc001gbv.2	+	10	1578	c.1191G>T	c.(1189-1191)GAG>GAT	p.E397D	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.E392D|NOS1AP_uc009wut.1_Missense_Mutation_p.E102D	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	397					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CTAAGCCAGAGGACCTGCATT	0.667			NA											22	96					9.57634e-11	1.18199e-10	0.00333	1	0
NUF2	83540	broad.mit.edu	37	1	163298635	163298635	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:163298635G>T	uc001gcq.1	+	5	576	c.276_splice	c.e5-1	p.L92_splice	NUF2_uc001gcp.2_Splice_Site_p.L92_splice|NUF2_uc001gcr.1_Splice_Site_p.L92_splice|NUF2_uc009wvc.1_Splice_Site_p.L92_splice	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component						cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TCATCTTCAAGGGACTCATTT	0.333			NA											87	294					6.00251e-64	1.1025e-63	0.00361	1	0
BAT2L2	23215	broad.mit.edu	37	1	171482234	171482234	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:171482234C>G	uc010pmg.1	+	3	473	c.207C>G	c.(205-207)GGC>GGG	p.G69G	BAT2L2_uc001ghq.1_Silent_p.G71G|BAT2L2_uc001ghr.1_Silent_p.G71G	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	69							protein C-terminus binding				0						AAAACAAAGGCAATGATCCTA	0.423			NA											9	379					0	0	0.008291	0	0
KLHL20	27252	broad.mit.edu	37	1	173735426	173735426	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:173735426G>T	uc001gjc.2	+	8	1472	c.1293G>T	c.(1291-1293)GAG>GAT	p.E431D	KLHL20_uc010pmr.1_Missense_Mutation_p.E242D|KLHL20_uc009wwf.2_Missense_Mutation_p.E413D	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	431	Kelch 3.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						ACATTGTTGAGAGGTGATCTT	0.343	GBM(159;862 2695 6559 23041)		NA											151	353					2.18101e-91	4.15431e-91	0.00361	1	0
PAPPA2	60676	broad.mit.edu	37	1	176525673	176525673	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:176525673C>G	uc001gkz.2	+	2	1379	c.215C>G	c.(214-216)CCC>CGC	p.P72R	PAPPA2_uc001gky.1_Missense_Mutation_p.P72R|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	72					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGAGTCTACCCCAGCAGGGCT	0.557			NA											181	494					0	0	0.00361	0	0
PAPPA2	60676	broad.mit.edu	37	1	176734882	176734882	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:176734882C>G	uc001gkz.2	+	15	5396	c.4232C>G	c.(4231-4233)TCT>TGT	p.S1411C	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1411	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AACTGTACCTCTATAGGCCCA	0.517			NA											31	660					0	0	0.002852	0	0
RALGPS2	55103	broad.mit.edu	37	1	178854254	178854255	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:178854254_178854255GG>CT	uc001glz.2	+	12	1286_1287	c.948_949GG>CT	c.(946-951)GTGGCA>GTCTCA	p.A317S	RALGPS2_uc010pnb.1_Missense_Mutation_p.A317S	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	317					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						GAAAAAGTGTGGCAGCTGAAGG	0.446			NA											34	64					0	0	0.004672	0	0
CACNA1E	777	broad.mit.edu	37	1	181689959	181689959	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:181689959A>C	uc001gow.2	+	15	2089	c.1924A>C	c.(1924-1926)ACC>CCC	p.T642P	CACNA1E_uc009wxs.2_Missense_Mutation_p.T549P	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	642	Extracellular (Potential).|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AAATTTTGATACCTTCCCTGC	0.428			NA											12	35					0	0	0.008871	0	0
CACNA1E	777	broad.mit.edu	37	1	181759585	181759585	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:181759585G>T	uc001gow.2	+	44	5956	c.5791G>T	c.(5791-5793)GGC>TGC	p.G1931C	CACNA1E_uc009wxs.2_Missense_Mutation_p.G1819C|CACNA1E_uc009wxt.2_Missense_Mutation_p.G1157C	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1931	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTTCAGGAGTGGCCGGAGTGG	0.542			NA											15	67					7.87624e-14	1.03107e-13	0.00278	1	0
LAMC1	3915	broad.mit.edu	37	1	183090909	183090909	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:183090909G>T	uc001gpy.3	+	12	2299	c.2042G>T	c.(2041-2043)GGA>GTA	p.G681V		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	681	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGGGCCTGGAGTCCCTGCA	0.493			NA											60	173					5.44642e-36	8.8854e-36	0.00361	1	0
APOBEC4	403314	broad.mit.edu	37	1	183617876	183617876	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:183617876G>A	uc001gqn.2	-	2	313	c.41C>T	c.(40-42)ACA>ATA	p.T14I	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron	NM_203454	NP_982279	Q8WW27	ABEC4_HUMAN	apolipoprotein B	14					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0						TTTTACTATTGTTCCATGATT	0.378			NA											53	195					0	0	0.00361	0	0
HMCN1	83872	broad.mit.edu	37	1	185892747	185892747	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:185892747A>G	uc001grq.1	+	8	1476	c.1247A>G	c.(1246-1248)CAG>CGG	p.Q416R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	416					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TACCTCTTCCAGAGAGTATCA	0.358			NA											37	95					0	0	0.007835	0	0
FAM5C	339479	broad.mit.edu	37	1	190067423	190067423	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:190067423C>G	uc001gse.1	-	8	2258	c.2026G>C	c.(2026-2028)GAC>CAC	p.D676H	FAM5C_uc010pot.1_Missense_Mutation_p.D574H	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	676						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GCTTCAGGGTCAAAGTGCATG	0.458			NA											58	270					0	0	0.00361	0	0
FAM5C	339479	broad.mit.edu	37	1	190250721	190250721	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:190250721C>A	uc001gse.1	-	3	628	c.396G>T	c.(394-396)GGG>GGT	p.G132G	FAM5C_uc010pot.1_Intron	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	132						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AGAAATGTGTCCCATATTTCT	0.453			NA											38	139					4.67007e-22	6.87149e-22	0.00874	1	0
CDC73	79577	broad.mit.edu	37	1	193111176	193111176	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:193111176A>G	uc001gtb.2	+	7	952	c.709A>G	c.(709-711)ATC>GTC	p.I237V		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	237					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						ACGAACAACTATCTTACAAAG	0.403			NA							Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				14	200					0	0	0.010504	0	0
CFH	3075	broad.mit.edu	37	1	196654266	196654266	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:196654266A>C	uc001gtj.3	+	7	1103	c.863A>C	c.(862-864)GAT>GCT	p.D288A	CFH_uc001gti.3_Missense_Mutation_p.D288A|CFH_uc009wyw.2_Missense_Mutation_p.D288A|CFH_uc009wyx.2_Missense_Mutation_p.D224A	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	288	Sushi 5.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AGAACTGGAGATGAAATCACG	0.383			NA											15	749					0	0	0.004007	0	0
CFHR4	10877	broad.mit.edu	37	1	196871741	196871741	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:196871741C>A	uc001gto.2	+	2	321	c.252C>A	c.(250-252)TGC>TGA	p.C84*	CFHR4_uc009wyy.2_Nonsense_Mutation_p.C83*|CFHR4_uc001gtp.2_Nonsense_Mutation_p.C84*	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	84	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CGGTCCCATGCCTCAGTAAGT	0.348			NA											101	237					3.20437e-51	5.61804e-51	0.00361	1	0
CFHR5	81494	broad.mit.edu	37	1	196967432	196967432	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:196967432C>A	uc001gts.3	+	7	1273	c.1145C>A	c.(1144-1146)ACA>AAA	p.T382K		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	382	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GTAGACTGCACAGGTAAGATT	0.279			NA											13	68					3.45872e-05	3.83513e-05	0.004007	1	0
ASPM	259266	broad.mit.edu	37	1	197070066	197070066	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:197070066T>C	uc001gtu.2	-	18	8572	c.8315A>G	c.(8314-8316)CAA>CGA	p.Q2772R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.Q620R	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2772					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GAGTGCAGATTGGTTAACAAT	0.383			NA											34	257					0	0	0.00623	0	0
CRB1	23418	broad.mit.edu	37	1	197396677	197396677	+	Missense_Mutation	SNP	T	T	C	rs62636267		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:197396677T>C	uc001gtz.2	+	7	2357	c.2222T>C	c.(2221-2223)ATG>ACG	p.M741T	CRB1_uc010poz.1_Missense_Mutation_p.M672T|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.M629T|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.M222T|CRB1_uc001gub.1_Missense_Mutation_p.M390T	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	741	Extracellular (Potential).|Laminin G-like 2.		M -> T (in LCA8).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCCTCTCCATGTTTGTCCGA	0.468			NA											4	109					0	0	0.009096	0	0
LHX9	56956	broad.mit.edu	37	1	197890482	197890482	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:197890482C>A	uc001guk.1	+	3	863	c.426C>A	c.(424-426)GCC>GCA	p.A142A	LHX9_uc001gui.1_Silent_p.A133A|LHX9_uc001guj.1_Silent_p.A148A	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	142	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCATTTCCGCCTCGGAGATGG	0.572			NA											12	72					2.61681e-11	3.2597e-11	0.00245	1	0
CACNA1S	779	broad.mit.edu	37	1	201029820	201029820	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:201029820A>G	uc001gvv.2	-	26	3607	c.3380T>C	c.(3379-3381)CTC>CCC	p.L1127P		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1127	IV.|Helical; Name=S1 of repeat IV; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GAGCATGATGAGGGCAAACAT	0.537			NA											9	390					0	0	0.000978	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202398051	202398051	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:202398051G>T	uc001gya.1	+	6	1059	c.915G>T	c.(913-915)CAG>CAT	p.Q305H	PPP1R12B_uc001gxy.2_Missense_Mutation_p.Q305H|PPP1R12B_uc009xad.1_Missense_Mutation_p.Q111H|PPP1R12B_uc009xae.1_Missense_Mutation_p.Q305H|PPP1R12B_uc001gxz.1_Missense_Mutation_p.Q305H	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	305					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			AGAAGAAGCAGAATGTGGTGA	0.453			NA											17	88					6.33239e-15	8.40169e-15	0.010504	1	0
PRELP	5549	broad.mit.edu	37	1	203452395	203452395	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:203452395C>A	uc001gzs.2	+	2	283	c.83C>A	c.(82-84)CCC>CAC	p.P28H	PRELP_uc001gzt.2_Missense_Mutation_p.P28H	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	28					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			CGACCAAGACCCGGGACTGGG	0.647			NA											18	46					7.26314e-15	9.58948e-15	0.007291	1	0
CNTN2	6900	broad.mit.edu	37	1	205030382	205030382	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:205030382C>A	uc001hbr.2	+	8	1076	c.807C>A	c.(805-807)CCC>CCA	p.P269P	CNTN2_uc001hbq.1_Silent_p.P160P|CNTN2_uc009xbi.2_Silent_p.P160P|CNTN2_uc001hbs.2_Silent_p.P57P	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	269	Ig-like C2-type 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCCCTGTCCCCCGGATCAAGT	0.652	Melanoma(183;2548 2817 37099 41192)		NA									OREG0014144	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	34					6.49762e-13	8.38403e-13	0.006122	1	0
CNTN2	6900	broad.mit.edu	37	1	205042265	205042265	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:205042265C>A	uc001hbr.2	+	22	3183	c.2914C>A	c.(2914-2916)CCA>ACA	p.P972T	CNTN2_uc001hbs.2_Missense_Mutation_p.P760T	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	972	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GATAGAAATCCCAGTGCCTGA	0.557	Melanoma(183;2548 2817 37099 41192)		NA											15	85					1.49906e-05	1.6725e-05	0.00245	1	0
SRGAP2	23380	broad.mit.edu	37	1	206611329	206611329	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:206611329C>T	uc001hdy.2	+	13	1721	c.1388C>T	c.(1387-1389)GCT>GTT	p.A463V	SRGAP2_uc010prt.1_Missense_Mutation_p.A386V|SRGAP2_uc001hdx.2_Missense_Mutation_p.A463V|SRGAP2_uc010pru.1_Missense_Mutation_p.A386V|SRGAP2_uc010prv.1_Missense_Mutation_p.A387V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	550	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					GACCCCCTGGCTGGGGACCAG	0.542			NA											56	186					0	0	0.00361	0	0
SRGAP2	23380	broad.mit.edu	37	1	206634713	206634713	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:206634713G>T	uc001hdy.2	+	20	3236	c.2903G>T	c.(2902-2904)GGT>GTT	p.G968V	SRGAP2_uc010pru.1_Missense_Mutation_p.G891V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	1055					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					ACTAGCCCTGGTGTCAACTCA	0.502			NA											70	165					2.0464e-58	3.67739e-58	0.00361	1	0
C1orf116	79098	broad.mit.edu	37	1	207195442	207195442	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:207195442G>T	uc001hfd.2	-	4	1926	c.1667C>A	c.(1666-1668)TCC>TAC	p.S556Y	C1orf116_uc009xcb.1_Missense_Mutation_p.S310Y	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	556						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					CAGGCGCTTGGAGCTCTGCTC	0.597			NA											7	54					0.000274275	0.000298005	0.004482	1	0
KCNH1	3756	broad.mit.edu	37	1	211256166	211256166	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:211256166C>A	uc001hib.2	-	5	684	c.514G>T	c.(514-516)GTG>TTG	p.V172L	KCNH1_uc001hic.2_Missense_Mutation_p.V172L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	172	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCTTTTTGCACGCTTGGAGCC	0.562			NA											130	300					6.47883e-55	1.15084e-54	0.00361	1	0
KCTD3	51133	broad.mit.edu	37	1	215759874	215759874	+	Silent	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:215759874G>C	uc001hks.2	+	9	957	c.663G>C	c.(661-663)ACG>ACC	p.T221T	KCTD3_uc001hkt.2_Silent_p.T221T|KCTD3_uc010pub.1_Silent_p.T119T|KCTD3_uc009xdn.2_5'UTR	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	221						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		AAGTGTTTACGAGCCCATATT	0.443			NA											95	407					0	0	0.00361	0	0
USH2A	7399	broad.mit.edu	37	1	216051129	216051129	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:216051129C>T	uc001hku.1	-	43	9039	c.8652G>A	c.(8650-8652)CAG>CAA	p.Q2884Q		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2884	Extracellular (Potential).|Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATAAAGCCACTGAGTTCCTG	0.383			NA								HNSCC(13;0.011)			131	390					0	0	0.00361	0	0
USH2A	7399	broad.mit.edu	37	1	216143975	216143975	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:216143975C>A	uc001hku.1	-	36	7336	c.6949G>T	c.(6949-6951)GGC>TGC	p.G2317C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2317	Fibronectin type-III 9.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCAGTGGGCCCAGAGCACAA	0.453			NA								HNSCC(13;0.011)			72	142					9.08522e-28	1.40574e-27	0.00361	1	0
USH2A	7399	broad.mit.edu	37	1	216496873	216496873	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:216496873G>T	uc001hku.1	-	8	1880	c.1493C>A	c.(1492-1494)ACT>AAT	p.T498N	USH2A_uc001hkv.2_Missense_Mutation_p.T498N	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	498	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTAACAGCAGTCTCAGTTGT	0.368			NA								HNSCC(13;0.011)			117	318					5.787e-82	1.09265e-81	0.00361	1	0
MARK1	4139	broad.mit.edu	37	1	220752848	220752848	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:220752848G>A	uc001hmn.3	+	2	801	c.204G>A	c.(202-204)AAG>AAA	p.K68K	MARK1_uc001hml.2_Silent_p.K68K|MARK1_uc009xdw.2_Silent_p.K68K|MARK1_uc010pun.1_Silent_p.K68K|MARK1_uc001hmm.3_Silent_p.K68K	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	68	ATP (By similarity).|Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CAATAGGGAAGGGAAATTTTG	0.433			NA											11	228					0	0	0.003163	0	0
OBSCN	84033	broad.mit.edu	37	1	228523918	228523918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:228523918C>A	uc009xez.1	+	64	16528	c.16484C>A	c.(16483-16485)TCA>TAA	p.S5495*	OBSCN_uc001hsn.2_Nonsense_Mutation_p.S5495*|OBSCN_uc001hsr.1_Nonsense_Mutation_p.S123*	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5495					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CAAGCCATCTCAGCACAGGGG	0.572			NA											16	49					4.96729e-08	5.80592e-08	0.008871	1	0
LYST	1130	broad.mit.edu	37	1	235973688	235973688	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:235973688T>C	uc001hxj.2	-	5	605	c.430A>G	c.(430-432)AGA>GGA	p.R144G	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R144G	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	144					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CGCTGTCGTCTGCTTTTTCGA	0.398			NA							Chediak-Higashsyndrome				26	276					0	0	0.002445	0	0
NID1	4811	broad.mit.edu	37	1	236195859	236195859	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:236195859G>T	uc001hxo.2	-	6	1481	c.1379C>A	c.(1378-1380)TCT>TAT	p.S460Y	NID1_uc009xgd.2_Missense_Mutation_p.S460Y	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	460	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TACTACGTAAGAGTGGAGGTC	0.552			NA											27	63					1.13719e-10	1.39723e-10	0.008361	1	0
NID1	4811	broad.mit.edu	37	1	236201439	236201439	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:236201439C>A	uc001hxo.2	-	5	1352	c.1250G>T	c.(1249-1251)GGC>GTC	p.G417V	NID1_uc009xgd.2_Missense_Mutation_p.G417V	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	417	EGF-like 1.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCCCGTATAGCCAGCGACACA	0.542			NA											30	159					3.11337e-16	4.23482e-16	0.002836	1	0
RYR2	6262	broad.mit.edu	37	1	237729943	237729943	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:237729943G>A	uc001hyl.1	+	28	3411	c.3291G>A	c.(3289-3291)AAG>AAA	p.K1097K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1097	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGCAGTGAAGGCCGGACGGT	0.557			NA											81	282					0	0	0.00361	0	0
RYR2	6262	broad.mit.edu	37	1	237798280	237798280	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:237798280G>A	uc001hyl.1	+	44	6900	c.6780G>A	c.(6778-6780)CCG>CCA	p.P2260P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2260	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCGTGAGCCGGATCTAGAAA	0.393			NA											6	69					0	0	0.001984	0	0
RYR2	6262	broad.mit.edu	37	1	237955446	237955446	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:237955446G>T	uc001hyl.1	+	94	13725	c.13605G>T	c.(13603-13605)ACG>ACT	p.T4535T	RYR2_uc010pyb.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4535					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCTCCCCACGAGAAGTTCAA	0.463			NA											5	57					0.000602214	0.000648446	0.000602	1	0
ZP4	57829	broad.mit.edu	37	1	238051764	238051764	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:238051764C>A	uc001hym.2	-	4	447	c.447G>T	c.(445-447)CGG>CGT	p.R149R	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	149	P-type.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCAGTCTGTCCCGTGCTGGGA	0.473	NSCLC(166;160 2029 11600 18754 19936)		NA											83	330					6.50375e-52	1.14212e-51	0.00361	1	0
NLRP3	114548	broad.mit.edu	37	1	247587802	247587802	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247587802G>T	uc001icr.2	+	5	1195	c.1057G>T	c.(1057-1059)GTG>TTG	p.V353L	NLRP3_uc001ics.2_Missense_Mutation_p.V353L|NLRP3_uc001icu.2_Missense_Mutation_p.V353L|NLRP3_uc001icw.2_Missense_Mutation_p.V353L|NLRP3_uc001icv.2_Missense_Mutation_p.V353L|NLRP3_uc010pyw.1_Missense_Mutation_p.V351L|NLRP3_uc001ict.1_Missense_Mutation_p.V351L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	353	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CACGAGACCTGTGGCCCTGGA	0.557			NA											35	161					1.3203e-36	2.1605e-36	0.00361	1	0
OR2B11	127623	broad.mit.edu	37	1	247614463	247614463	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247614463C>A	uc010pyx.1	-	1	822	c.822G>T	c.(820-822)CAG>CAT	p.Q274H		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TAAATTTGCCCTGCTCTTGGG	0.493			NA											94	339					1.21964e-59	2.20269e-59	0.00361	1	0
OR2C3	81472	broad.mit.edu	37	1	247695356	247695356	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247695356C>A	uc009xgy.2	-	2	820	c.458G>T	c.(457-459)GGT>GTT	p.G153V	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GGTGGTCAGACCCCCCAGCCA	0.562			NA											12	24					1.49906e-05	1.6725e-05	0.00245	1	0
OR2G2	81470	broad.mit.edu	37	1	247752128	247752128	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247752128T>C	uc010pyy.1	+	1	467	c.467T>C	c.(466-468)ATA>ACA	p.I156T		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCAGTGGAATAGCCACCACC	0.547			NA											201	592					0	0	0.00361	0	0
OR2G3	81469	broad.mit.edu	37	1	247769640	247769640	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247769640C>A	uc010pyz.1	+	1	753	c.753C>A	c.(751-753)TTC>TTA	p.F251L		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGATTATATTCTATGGCACCA	0.488			NA											30	157					9.21846e-06	1.04033e-05	0.002836	1	0
OR14A16	284532	broad.mit.edu	37	1	247978554	247978554	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247978554C>A	uc001idm.1	-	1	478	c.478G>T	c.(478-480)GGC>TGC	p.G160C		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAGAAGGTGCCAGCTGTGTGC	0.473	Ovarian(112;180 1586 15073 21914 33526)		NA											103	513					6.25825e-54	1.10802e-53	0.00361	1	0
OR2W3	343171	broad.mit.edu	37	1	248059311	248059311	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248059311C>G	uc001idp.1	+	3	692	c.423C>G	c.(421-423)TGC>TGG	p.C141W	OR2W3_uc010pzb.1_Missense_Mutation_p.C141W	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCAGGCTCTGCCGGGGCTTGG	0.627			NA											27	104					0	0	0.004656	0	0
OR2W3	343171	broad.mit.edu	37	1	248059622	248059622	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248059622T>A	uc001idp.1	+	3	1003	c.734T>A	c.(733-735)CTC>CAC	p.L245H	OR2W3_uc010pzb.1_Missense_Mutation_p.L245H	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTCCCATCTCACTGTGGTC	0.512			NA											14	388					0	0	0.00245	0	0
OR2T8	343172	broad.mit.edu	37	1	248084416	248084416	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248084416G>T	uc010pzc.1	+	1	97	c.97G>T	c.(97-99)GTT>TTT	p.V33F		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCTGAGTATCGTTTTGACCTC	0.483			NA											32	212					1.8453e-21	2.7041e-21	0.002522	1	0
OR2L3	391192	broad.mit.edu	37	1	248224532	248224532	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248224532G>A	uc001idx.1	+	1	549	c.549G>A	c.(547-549)ATG>ATA	p.M183I	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCCCAGCAATGGTGACTCTGG	0.463			NA											110	702					0	0	0.00361	0	0
OR2M7	391196	broad.mit.edu	37	1	248487614	248487614	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248487614A>T	uc010pzk.1	-	1	257	c.257T>A	c.(256-258)TTG>TAG	p.L86*		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCCAGACAAGTAGTTGAA	0.493			NA											189	628					0	0	0.00361	0	0
OR2M7	391196	broad.mit.edu	37	1	248487866	248487866	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248487866G>T	uc010pzk.1	-	1	5	c.5C>A	c.(4-6)GCA>GAA	p.A2E		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTCTCCCATGCCATGATGAA	0.428			NA											101	498					9.84861e-36	1.60188e-35	0.00361	1	0
OR2T1	26696	broad.mit.edu	37	1	248569631	248569631	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248569631C>G	uc010pzm.1	+	1	336	c.336C>G	c.(334-336)CTC>CTG	p.L112L		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	112	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTACTTCCTCCTCAGCCACC	0.438			NA											15	574					0	0	0.00499	0	0
OR2G6	391211	broad.mit.edu	37	1	248685280	248685280	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248685280G>A	uc001ien.1	+	1	333	c.333G>A	c.(331-333)GAG>GAA	p.E111E		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTCGTCTGAGTGTATTCTCT	0.552			NA											49	543					0	0	0.00361	0	0
OR2T34	127068	broad.mit.edu	37	1	248737445	248737445	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248737445T>A	uc001iep.1	-	1	614	c.614A>T	c.(613-615)TAC>TTC	p.Y205F		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGCACAGGTACGTGAGCAT	0.527			NA											153	652					0	0	0.00361	0	0
OR2T10	127069	broad.mit.edu	37	1	248756948	248756948	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:248756948C>G	uc010pzn.1	-	1	122	c.122G>C	c.(121-123)TGG>TCG	p.W41S		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTAATATTCCAAGACACAGC	0.423			NA											67	75					0	0	0.00361	0	0
ZMYND11	10771	broad.mit.edu	37	10	294355	294355	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:294355T>C	uc010pzt.1	+	13	1735	c.1307T>C	c.(1306-1308)GTG>GCG	p.V436A	ZMYND11_uc001ifk.2_Missense_Mutation_p.V435A|ZMYND11_uc010pzu.1_Missense_Mutation_p.V436A|ZMYND11_uc010pzv.1_Missense_Mutation_p.V381A|ZMYND11_uc010pzw.1_Missense_Mutation_p.V351A|ZMYND11_uc001ifm.2_Missense_Mutation_p.V382A|ZMYND11_uc010pzx.1_Missense_Mutation_p.V436A|ZMYND11_uc001ifn.2_Missense_Mutation_p.V382A|ZMYND11_uc009xhg.2_Missense_Mutation_p.V419A|ZMYND11_uc009xhh.2_Missense_Mutation_p.V310A|ZMYND11_uc010pzy.1_Missense_Mutation_p.V288A	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	396					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AAAGTCTCCGTGTCAACTCAG	0.498			NA											29	93					0	0	0.002096	0	0
DIP2C	22982	broad.mit.edu	37	10	409175	409175	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:409175C>T	uc001ifp.2	-	21	2644	c.2554G>A	c.(2554-2556)GAA>AAA	p.E852K	DIP2C_uc009xhi.1_Missense_Mutation_p.E238K|DIP2C_uc010pzz.1_Missense_Mutation_p.E173K	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	852						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTGTCCTCTTCCGTGGAGTCA	0.607			NA											17	35					0	0	0.008871	0	0
LARP4B	23185	broad.mit.edu	37	10	860901	860901	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:860901G>A	uc001ifs.1	-	15	1846	c.1805C>T	c.(1804-1806)CCA>CTA	p.P602L		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	602							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						TAAATGAGCTGGGGAGGGGGA	0.547			NA											7	80					0	0	0.006214	0	0
ITIH2	3698	broad.mit.edu	37	10	7763676	7763676	+	Missense_Mutation	SNP	C	C	T	rs141514196		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:7763676C>T	uc001ijs.2	+	8	965	c.803C>T	c.(802-804)GCG>GTG	p.A268V		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	268					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						CGGGAGACTGCGGTAGATGGG	0.552			NA											13	96					0	0	0.00499	0	0
ITIH2	3698	broad.mit.edu	37	10	7773794	7773794	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:7773794C>A	uc001ijs.2	+	13	1644	c.1482C>A	c.(1480-1482)TCC>TCA	p.S494S		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	494					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						ACCAGGTCTCCACTCCATTGC	0.373			NA											54	303					6.05568e-20	8.66243e-20	0.00361	1	0
UCMA	221044	broad.mit.edu	37	10	13264144	13264144	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:13264144C>A	uc001imd.2	-	5	449	c.376G>T	c.(376-378)GGC>TGC	p.G126C		NM_145314	NP_660357	Q8WVF2	UCMA_HUMAN	upper zone of growth plate and cartilage matrix	126						proteinaceous extracellular matrix					0						GGGTGCAGGCCGTCATAGTGC	0.587			NA											16	69					3.32936e-07	3.84568e-07	0.006122	1	0
CUBN	8029	broad.mit.edu	37	10	16873350	16873350	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:16873350G>T	uc001ioo.2	-	65	10481	c.10429C>A	c.(10429-10431)CCT>ACT	p.P3477T		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3477	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAGAAGACAGGGTTTGGCAGC	0.393			NA											107	289					7.53784e-56	1.34338e-55	0.00361	1	0
CUBN	8029	broad.mit.edu	37	10	17169920	17169921	+	Nonsense_Mutation	DNP	GG	GG	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:17169920_17169921GG>AA	uc001ioo.2	-	3	307_308	c.255_256CC>TT	c.(253-258)ATCCAG>ATTTAG	p.Q86*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	86					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGTTTTTCTGGATCTAATTTT	0.282			NA											9	70					0	0	0.004672	0	0
ZEB1	6935	broad.mit.edu	37	10	31810643	31810643	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:31810643C>T	uc001ivs.3	+	7	2443	c.2380C>T	c.(2380-2382)CCA>TCA	p.P794S	ZEB1_uc001ivr.3_Missense_Mutation_p.P576S|ZEB1_uc010qee.1_Missense_Mutation_p.P576S|ZEB1_uc010qef.1_Missense_Mutation_p.P576S|ZEB1_uc009xlj.1_Missense_Mutation_p.P720S|ZEB1_uc010qeg.1_Missense_Mutation_p.P653S|ZEB1_uc009xlk.1_Missense_Mutation_p.P576S|ZEB1_uc001ivt.3_Missense_Mutation_p.P576S|ZEB1_uc001ivu.3_Missense_Mutation_p.P795S|ZEB1_uc001ivv.3_Missense_Mutation_p.P774S|ZEB1_uc010qeh.1_Missense_Mutation_p.P727S|ZEB1_uc009xlo.1_Missense_Mutation_p.P777S|ZEB1_uc009xlp.2_Missense_Mutation_p.P778S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	794					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAATGTAATCCCACCAAGTGC	0.453	Ovarian(40;423 959 14296 36701 49589)		NA											113	358					0	0	0.00361	0	0
HNRNPA3P1	10151	broad.mit.edu	37	10	44285232	44285232	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:44285232G>A	uc010qfe.1	-	1	634	c.604C>T	c.(604-606)CTT>TTT	p.L202F		NR_002726				SubName: Full=cDNA FLJ52659, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=cDNA, FLJ79333, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=Heterogeneous nuclear ribonucleoprotein A3, isoform CRA_a;												0						TGTTTAGCAAGGGCCTTTTTC	0.388			NA											4	58					0	0	0.001168	0	0
ALOX5	240	broad.mit.edu	37	10	45907644	45907644	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:45907644T>A	uc001jce.2	+	4	536	c.437T>A	c.(436-438)ATG>AAG	p.M146K	ALOX5_uc009xmt.2_Missense_Mutation_p.M146K|ALOX5_uc010qfg.1_Missense_Mutation_p.M146K	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	146	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CTCAGATGGATGGAGTGGAAC	0.498			NA											4	74					0	0	0.001168	0	0
PPYR1	5540	broad.mit.edu	37	10	47087209	47087209	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:47087209C>T	uc001jee.2	+	3	845	c.426C>T	c.(424-426)CTC>CTT	p.L142L	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.L142L	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	142	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						GGCATCAGCTCATCATCAACC	0.592			NA											46	371					0	0	0.00361	0	0
FRMPD2	143162	broad.mit.edu	37	10	49444598	49444598	+	Splice_Site	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:49444598T>A	uc001jgi.2	-	9	1029	c.922_splice	c.e9-1	p.F308_splice	FRMPD2_uc001jgh.2_Splice_Site_p.F277_splice|FRMPD2_uc001jgj.2_Splice_Site_p.F286_splice	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3						tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCTGGAAAACTGGAGGAAAAC	0.552			NA											11	92					0	0	0.00245	0	0
FRMPD2	143162	broad.mit.edu	37	10	49450216	49450216	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:49450216A>T	uc001jgi.2	-	5	662	c.555T>A	c.(553-555)GGT>GGA	p.G185G	FRMPD2_uc001jgh.2_Silent_p.G154G|FRMPD2_uc001jgj.2_Silent_p.G163G	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	185	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CAGAAATGGTACCCAGAACCA	0.323			NA											6	196					0	0	0.004482	0	0
A1CF	29974	broad.mit.edu	37	10	52580401	52580401	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:52580401C>G	uc001jjj.2	-	8	966	c.778G>C	c.(778-780)GAG>CAG	p.E260Q	A1CF_uc010qhn.1_Missense_Mutation_p.E268Q|A1CF_uc001jji.2_Missense_Mutation_p.E260Q|A1CF_uc001jjh.2_Missense_Mutation_p.E268Q|A1CF_uc010qho.1_Missense_Mutation_p.E268Q|A1CF_uc009xov.2_Missense_Mutation_p.E260Q	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	260	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TTCACCCTCTCCACAGCACCT	0.388			NA											14	124					0	0	0.007413	0	0
TET1	80312	broad.mit.edu	37	10	70446412	70446412	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:70446412G>T	uc001jok.3	+	11	5857	c.5352G>T	c.(5350-5352)AAG>AAT	p.K1784N		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1784					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCAAGCGGAAGAATAACTCAA	0.458			NA											30	284					1.47244e-24	2.23035e-24	0.00623	1	0
TET1	80312	broad.mit.edu	37	10	70450858	70450858	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:70450858G>T	uc001jok.3	+	12	6203	c.5698G>T	c.(5698-5700)GGC>TGC	p.G1900C		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1900					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TGATGGCCCTGGCATTTCACA	0.567			NA											16	136					2.35188e-11	2.94326e-11	0.006122	1	0
KIAA1274	27143	broad.mit.edu	37	10	72293678	72293678	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:72293678G>T	uc001jrd.3	+	8	1152	c.871G>T	c.(871-873)GAG>TAG	p.E291*		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	291										ovary(2)|central_nervous_system(1)	3						TCTTTCCCAGGAGACCCCCAG	0.652			NA											5	49					0.000602214	0.000648446	0.000602	1	0
UNC5B	219699	broad.mit.edu	37	10	73047403	73047403	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:73047403G>T	uc001jro.2	+	6	1227	c.782G>T	c.(781-783)CGC>CTC	p.R261L	UNC5B_uc001jrp.2_Missense_Mutation_p.R261L	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	261	TSP type-1 1.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						TGCTCCAACCGCTGTGGCCGA	0.667			NA											9	35					5.4927e-09	6.56935e-09	0.004482	1	0
USP54	159195	broad.mit.edu	37	10	75290091	75290091	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:75290091C>T	uc001juo.2	-	12	1655	c.1638G>A	c.(1636-1638)AGG>AGA	p.R546R	USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Silent_p.R546R|USP54_uc010qkl.1_Silent_p.R546R	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	546					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					AAGGCAGGGTCCTAGGAGGTT	0.507	Colon(195;880 2046 8854 25025 38456)		NA											20	95					0	0	0.002299	0	0
MYST4	23522	broad.mit.edu	37	10	76736089	76736089	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:76736089G>T	uc001jwn.1	+	8	2486	c.1993_splice	c.e8+1	p.D665_splice	MYST4_uc001jwm.1_Intron|MYST4_uc001jwo.1_Intron|MYST4_uc001jwp.1_Intron	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic						histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CAGGATGATGGTAAGCAAAAG	0.473			NA	T	CREBBP	AML								20	86					2.41591e-17	3.34082e-17	0.004656	1	0
LRIT2	340745	broad.mit.edu	37	10	85982088	85982089	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:85982088_85982089CC>AA	uc001kcy.2	-	3	1248_1249	c.1240_1241GG>TT	c.(1240-1242)GGA>TTA	p.G414L	LRIT2_uc010qmc.1_Missense_Mutation_p.G424L	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	414	Fibronectin type-III.					integral to membrane				ovary(2)	2						AGTATTGATTCCGGGGCCAATG	0.554			NA											66	85					0	0	0.004672	0	0
GRID1	2894	broad.mit.edu	37	10	87628799	87628799	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:87628799C>A	uc001kdl.1	-	6	1020	c.919G>T	c.(919-921)GAC>TAC	p.D307Y	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	307	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TCCTGGGGGTCGCAGAGCAGG	0.582			NA								Multiple Myeloma(13;0.14)			77	113					4.02937e-33	6.43745e-33	0.00361	1	0
LIPK	643414	broad.mit.edu	37	10	90486557	90486557	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:90486557G>C	uc010qmv.1	+	2	111	c.111G>C	c.(109-111)CAG>CAC	p.Q37H		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	37					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		TTTAGAGCCAGATTATTTCTT	0.289			NA											14	15					0	0	0.00499	0	0
LIPK	643414	broad.mit.edu	37	10	90499787	90499787	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:90499787C>T	uc010qmv.1	+	7	851	c.851C>T	c.(850-852)GCG>GTG	p.A284V		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	284					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		CACAATCCTGCGGGAACATCT	0.423			NA											78	182					0	0	0.00361	0	0
PDE6C	5146	broad.mit.edu	37	10	95425130	95425130	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:95425130A>T	uc001kiu.3	+	22	2670	c.2532A>T	c.(2530-2532)TCA>TCT	p.S844S		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	844					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				CTGAAGATTCAGGAGGTGGTG	0.318			NA											58	163					0	0	0.00361	0	0
PLCE1	51196	broad.mit.edu	37	10	96005857	96005858	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:96005857_96005858CA>AG	uc001kjk.2	+	8	3209_3210	c.2575_2576CA>AG	c.(2575-2577)CAG>AGG	p.Q859R	PLCE1_uc010qnx.1_Missense_Mutation_p.Q859R|PLCE1_uc001kjm.2_Missense_Mutation_p.Q551R	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	859					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CGATGTGCACCAGTTCCTGCTG	0.584			NA											78	88					0	0	0.004672	0	0
C10orf12	26148	broad.mit.edu	37	10	98743749	98743749	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:98743749T>A	uc001kmv.2	+	1	2709	c.2602T>A	c.(2602-2604)TTT>ATT	p.F868I		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	868										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TATGACAAACTTTAAATTATC	0.398			NA											4	123					0	0	0.009096	0	0
SLIT1	6585	broad.mit.edu	37	10	98802742	98802742	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:98802742C>T	uc001kmw.2	-	20	2332	c.2080G>A	c.(2080-2082)GGG>AGG	p.G694R	SLIT1_uc009xvh.1_Missense_Mutation_p.G704R	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	694	LRRCT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CGCGGGTTCCCCGTCACGATC	0.612			NA											17	39					0	0	0.00499	0	0
LOXL4	84171	broad.mit.edu	37	10	100017495	100017495	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:100017495G>T	uc001kpa.1	-	8	1323	c.1172C>A	c.(1171-1173)CCT>CAT	p.P391H		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	391	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		TTCCAGGGCAGGGCAGTCGCT	0.582			NA											27	47					3.09479e-21	4.49848e-21	0.006999	1	0
LZTS2	84445	broad.mit.edu	37	10	102763886	102763886	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:102763886G>T	uc001ksj.2	+	3	1100	c.1031G>T	c.(1030-1032)CGG>CTG	p.R344L	LZTS2_uc010qpw.1_Missense_Mutation_p.R344L|LZTS2_uc001ksk.2_Missense_Mutation_p.R344L|LZTS2_uc001ksl.2_Missense_Mutation_p.R344L|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	344	Potential.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CAGCAGCTGCGGGACAGTCTG	0.622	Esophageal Squamous(8;38 437 13604 19902 37640)		NA											11	22					6.31663e-08	7.35918e-08	0.003163	1	0
C10orf76	79591	broad.mit.edu	37	10	103773753	103773753	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:103773753G>C	uc009xwy.1	-	9	800	c.698C>G	c.(697-699)TCT>TGT	p.S233C		NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	233						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		ATCCACGATAGACAGCTTCAC	0.378			NA											6	420					0	0	0.004482	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988649	103988649	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:103988649A>T	uc001kut.2	+	4	616	c.453A>T	c.(451-453)ACA>ACT	p.T151T		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	151					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		ACCACAGCACAGTGCTCGTGT	0.498			NA											37	54					0	0	0.003214	0	0
PSD	5662	broad.mit.edu	37	10	104173662	104173662	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:104173662C>G	uc001kvg.1	-	5	1944	c.1417G>C	c.(1417-1419)GCT>CCT	p.A473P	PSD_uc001kvh.1_Missense_Mutation_p.A94P|PSD_uc009xxd.1_Missense_Mutation_p.A473P	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	473					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CCATCAGCAGCAGAGCTGGTA	0.662			NA											8	13					0	0	0.001855	0	0
CALHM2	51063	broad.mit.edu	37	10	105209690	105209690	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:105209690G>T	uc001kwz.2	-	2	395	c.9C>A	c.(7-9)GCC>GCA	p.A3A	CALHM2_uc001kxa.2_Silent_p.A3A|CALHM2_uc001kxc.2_Silent_p.A3A|CALHM2_uc001kxb.2_Silent_p.A3A|CALHM2_uc001kxd.1_Silent_p.A3A	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	3						integral to membrane				skin(1)	1						CTGCGATCAGGGCTGCCATGG	0.587			NA											19	30					6.32553e-13	8.18152e-13	0.004656	1	0
SORCS3	22986	broad.mit.edu	37	10	106802840	106802840	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:106802840C>G	uc001kyi.1	+	5	1209	c.982C>G	c.(982-984)CGG>GGG	p.R328G		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	328	BNR 3.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTTTGGAAGACGGTGGCAACT	0.438	NSCLC(116;1497 1690 7108 13108 14106)		NA											187	471					0	0	0.00361	0	0
TCF7L2	6934	broad.mit.edu	37	10	114912190	114912190	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:114912190G>T	uc001lae.3	+	11	1767	c.1260G>T	c.(1258-1260)CGG>CGT	p.R420R	TCF7L2_uc001lac.3_Silent_p.R397R|TCF7L2_uc010qrk.1_Silent_p.R397R|TCF7L2_uc010qrl.1_Silent_p.R397R|TCF7L2_uc010qrm.1_Silent_p.R420R|TCF7L2_uc010qrn.1_Silent_p.R363R|TCF7L2_uc001lad.3_Silent_p.R393R|TCF7L2_uc001lag.3_Silent_p.R444R|TCF7L2_uc001laf.3_Silent_p.R397R|TCF7L2_uc010qro.1_Silent_p.R397R|TCF7L2_uc001lah.2_Silent_p.R402R|TCF7L2_uc010qrp.1_Silent_p.R397R|TCF7L2_uc010qrq.1_Silent_p.R393R|TCF7L2_uc010qrr.1_Silent_p.R335R|TCF7L2_uc010qrs.1_Silent_p.R291R|TCF7L2_uc010qrt.1_Silent_p.R291R|TCF7L2_uc010qru.1_Silent_p.R319R|TCF7L2_uc010qrv.1_Silent_p.R237R|TCF7L2_uc010qrw.1_Silent_p.R124R|TCF7L2_uc010qrx.1_Silent_p.R277R	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	420					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		GGTCCGCGCGGGATAACTATG	0.522			NA											6	320					8.12818e-05	8.93935e-05	0.001984	1	0
C10orf82	143379	broad.mit.edu	37	10	118425181	118425181	+	Missense_Mutation	SNP	G	G	T	rs138140121	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:118425181G>T	uc001lcr.2	-	3	267	c.212C>A	c.(211-213)TCC>TAC	p.S71Y	C10orf82_uc001lcs.1_Missense_Mutation_p.S71Y	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	71											0				all cancers(201;0.0143)		CGTCTCCTCGGAGTTGACAGG	0.567			NA											18	40					6.44725e-10	7.83243e-10	0.002299	1	0
KCNK18	338567	broad.mit.edu	37	10	118960761	118960761	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:118960761C>T	uc010qsr.1	+	2	315	c.315C>T	c.(313-315)AGC>AGT	p.S105S		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	105						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CCTTCCTGAGCTCGCTCTTTT	0.557			NA											55	74					0	0	0.00361	0	0
ADAM12	8038	broad.mit.edu	37	10	127753557	127753557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:127753557C>A	uc001ljk.2	-	14	1849	c.1436G>T	c.(1435-1437)GGA>GTA	p.G479V	ADAM12_uc010qul.1_Missense_Mutation_p.G430V|ADAM12_uc001ljm.2_Missense_Mutation_p.G479V|ADAM12_uc001ljn.2_Missense_Mutation_p.G476V|ADAM12_uc001ljl.3_Missense_Mutation_p.G476V	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	479	Extracellular (Potential).|Disintegrin.		G -> E (in a breast cancer sample; somatic mutation).		cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding	p.G479E(1)		breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GCACGCTGTTCCTGCAGGCTT	0.607			NA											9	25					0.000673444	0.000722264	0.008291	1	0
GLRX3	10539	broad.mit.edu	37	10	131958334	131958334	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:131958334G>T	uc001lkm.1	+	3	298	c.276_splice	c.e3+1	p.K92_splice	GLRX3_uc001lkn.1_Splice_Site_p.K92_splice|GLRX3_uc001lko.2_Splice_Site	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3						cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		GTTTTTCAAGGTAAGGATAAA	0.368			NA											56	117					1.28914e-47	2.23838e-47	0.00361	1	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651332	1651332	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:1651332G>T	uc001lty.2	+	1	300	c.262G>T	c.(262-264)GGC>TGC	p.G88C		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	88	8 X 4 AA repeats of C-C-X-P.					keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGCAAAGGGGGCTGTGGCTC	0.577			NA											8	107					5.50884e-06	6.22337e-06	0.001368	1	0
STIM1	6786	broad.mit.edu	37	11	4104157	4104157	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:4104157C>T	uc001lyv.2	+	9	1751	c.1183C>T	c.(1183-1185)CAC>TAC	p.H395Y	STIM1_uc009yef.2_Missense_Mutation_p.H395Y|STIM1_uc009yeg.2_Missense_Mutation_p.H222Y	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	395	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		TGGCACCTTCCACGTGGCCCA	0.433			NA											74	230					0	0	0.00361	0	0
OR52B4	143496	broad.mit.edu	37	11	4389399	4389399	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:4389399C>A	uc010qye.1	-	1	127	c.127G>T	c.(127-129)GGG>TGG	p.G43W		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGCTGTTCCCAAGAAGGGCG	0.522			NA											36	294					2.05212e-20	2.94719e-20	0.005524	1	0
OR52K1	390036	broad.mit.edu	37	11	4510989	4510989	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:4510989C>G	uc001lza.1	+	1	859	c.859C>G	c.(859-861)CCC>GCC	p.P287A		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCTTTTCCCACCCATGGTCAA	0.463			NA											126	522					0	0	0.00361	0	0
OR51D1	390038	broad.mit.edu	37	11	4661635	4661635	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:4661635C>G	uc010qyk.1	+	1	615	c.615C>G	c.(613-615)ACC>ACG	p.T205T		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	205	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTACTGACACCAGGGTCAATG	0.468			NA											220	506					0	0	0.00361	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444315	5444315	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:5444315T>A	uc010qzd.1	+	1	885	c.885T>A	c.(883-885)AGT>AGA	p.S295R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATTTACAGTGTAAAGAACA	0.428			NA											23	162					0	0	0.003954	0	0
NLRP14	338323	broad.mit.edu	37	11	7092508	7092508	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:7092508A>T	uc001mfb.1	+	12	3574	c.3251A>T	c.(3250-3252)GAA>GTA	p.E1084V		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	1084					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TATCATAATGAAGAAGATGTG	0.338			NA											9	139					0	0	0.008291	0	0
INSC	387755	broad.mit.edu	37	11	15243085	15243085	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:15243085G>T	uc001mly.2	+	8	1069	c.1023G>T	c.(1021-1023)CGG>CGT	p.R341R	INSC_uc001mlz.2_Silent_p.R294R|INSC_uc001mma.2_Silent_p.R294R|INSC_uc010rcs.1_Silent_p.R329R|INSC_uc001mmb.2_Silent_p.R294R|INSC_uc001mmc.2_Silent_p.R252R	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	341					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						AGGCCACACGGGCTGAGGCTG	0.637			NA											19	57					2.97696e-44	5.11147e-44	0.00361	1	0
MRGPRX3	117195	broad.mit.edu	37	11	18159297	18159297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:18159297G>A	uc001mnu.2	+	3	909	c.548G>A	c.(547-549)TGG>TAG	p.W183*		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	183	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						ACAATCGCGTGGCTGGTTTTT	0.512			NA											20	173					0	0	0.002299	0	0
PTPN5	84867	broad.mit.edu	37	11	18754824	18754824	+	Silent	SNP	C	C	A	rs116891792	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:18754824C>A	uc001mpd.2	-	11	1607	c.1176G>T	c.(1174-1176)ACG>ACT	p.T392T	PTPN5_uc001mpb.2_Silent_p.T360T|PTPN5_uc001mpc.2_Silent_p.T392T|PTPN5_uc001mpe.2_Silent_p.T360T|PTPN5_uc010rdj.1_Silent_p.T336T|PTPN5_uc001mpf.2_Silent_p.T368T|PTPN5_uc010rdk.1_Silent_p.T337T	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	392	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						CAATGATGGGCGTGTGCTCCT	0.527			NA											13	92					1.02788e-11	1.29233e-11	0.00499	1	0
SLC6A5	9152	broad.mit.edu	37	11	20628585	20628585	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:20628585G>T	uc001mqd.2	+	4	985	c.712G>T	c.(712-714)GCT>TCT	p.A238S	SLC6A5_uc009yic.2_Missense_Mutation_p.A3S	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	238	Helical; Name=2; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	GATGATGCTGGCTCTGGCTGG	0.567			NA											41	66					8.30282e-39	1.37955e-38	0.00361	1	0
GAS2	2620	broad.mit.edu	37	11	22707259	22707259	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:22707259G>T	uc009yie.2	+	3	497	c.191G>T	c.(190-192)GGT>GTT	p.G64V	GAS2_uc001mqm.2_Missense_Mutation_p.G64V|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.G64V	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	64	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TTGGACAATGGTGCCTTGCTC	0.383			NA											25	149					1.2476e-16	1.71426e-16	0.00632	1	0
KCNA4	3739	broad.mit.edu	37	11	30032330	30032330	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:30032330C>A	uc001msk.2	-	2	3048	c.1896G>T	c.(1894-1896)AAG>AAT	p.K632N		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	632						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGTCATCCCCCTTTCCCTGAC	0.483			NA											58	147					7.48145e-19	1.05897e-18	0.00361	1	0
DEPDC7	91614	broad.mit.edu	37	11	33054339	33054339	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:33054339G>A	uc001mub.2	+	7	1355	c.1263G>A	c.(1261-1263)AAG>AAA	p.K421K	DEPDC7_uc001muc.2_Silent_p.K412K	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	421					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ATGTTTTTAAGGTAAAATTGT	0.294			NA											18	88					0	0	0.00333	0	0
C11orf41	25758	broad.mit.edu	37	11	33565835	33565835	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:33565835C>A	uc001mup.3	+	1	1959	c.1835C>A	c.(1834-1836)ACC>AAC	p.T612N	C11orf41_uc001mun.1_Missense_Mutation_p.T612N	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	612						integral to membrane				ovary(2)	2						TTTCCCAGGACCTCCTCCAGA	0.502			NA											26	388					7.26314e-15	9.58948e-15	0.007291	1	0
RAG1	5896	broad.mit.edu	37	11	36597537	36597537	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:36597537G>T	uc001mwu.3	+	2	2807	c.2683G>T	c.(2683-2685)GTA>TTA	p.V895L	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	895					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GATGAAACCAGTATGGCGATC	0.483	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				47	521					2.84144e-21	4.13578e-21	0.00361	1	0
EXT2	2132	broad.mit.edu	37	11	44228501	44228502	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:44228501_44228502GG>TT	uc001mxz.2	+	10	1988_1989	c.1654_1655GG>TT	c.(1654-1656)GGT>TTT	p.G552F	EXT2_uc010rfo.1_Missense_Mutation_p.G580F|EXT2_uc001mxy.2_Missense_Mutation_p.G565F|EXT2_uc009ykt.2_Missense_Mutation_p.G562F|EXT2_uc001mya.2_Missense_Mutation_p.G585F	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	552	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GCTGCAATTTGGTTATGAGGTA	0.351			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				71	319					0	0	0.004672	0	0
OR4B1	119765	broad.mit.edu	37	11	48238932	48238932	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:48238932T>C	uc010rhs.1	+	1	571	c.571T>C	c.(571-573)TTC>CTC	p.F191L		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						CACTGACACCTTCATGGAGGG	0.453			NA											19	572					0	0	0.001882	0	0
OR4A15	81328	broad.mit.edu	37	11	55135664	55135664	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:55135664C>A	uc010rif.1	+	1	305	c.305C>A	c.(304-306)TCT>TAT	p.S102Y		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	102	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACCGTCTATTCTACTGCATTT	0.413			NA											132	459					1.38722e-55	2.4682e-55	0.00361	1	0
OR5D14	219436	broad.mit.edu	37	11	55563649	55563649	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:55563649C>T	uc010rim.1	+	1	618	c.618C>T	c.(616-618)ACC>ACT	p.T206T		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GCTTCGCCACCTTCAATGAGA	0.433			NA											27	323					0	0	0.002096	0	0
OR8J1	219477	broad.mit.edu	37	11	56128272	56128272	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:56128272C>A	uc010rjh.1	+	1	550	c.550C>A	c.(550-552)CTG>ATG	p.L184M		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TAATGTTCCTCTGTTAGCATT	0.333			NA											53	158					2.93687e-30	4.65077e-30	0.00361	1	0
OR9G4	283189	broad.mit.edu	37	11	56510307	56510307	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:56510307T>C	uc010rjo.1	-	1	981	c.981A>G	c.(979-981)ACA>ACG	p.T327T		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATAACCTTCATGTTTGTGGTT	0.363			NA											79	275					0	0	0.00361	0	0
OR4D6	219983	broad.mit.edu	37	11	59224639	59224639	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:59224639T>C	uc010rku.1	+	1	206	c.206T>C	c.(205-207)CTG>CCG	p.L69P		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAATCAGTCCTGGACATCGTT	0.463			NA											38	163					0	0	0.00623	0	0
ZP1	22917	broad.mit.edu	37	11	60636728	60636728	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:60636728G>T	uc001nqd.2	+	2	327	c.307G>T	c.(307-309)GTG>TTG	p.V103L	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	103	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						AGGCTGCCACGTGCTGGAGAA	0.572			NA											4	17					0.00116845	0.00123961	0.001168	1	0
CYBASC3	220002	broad.mit.edu	37	11	61121427	61121427	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:61121427C>G	uc001nrf.3	-	2	398	c.222G>C	c.(220-222)GGG>GGC	p.G74G	CYBASC3_uc010rlh.1_Silent_p.G91G|CYBASC3_uc001nrg.2_Silent_p.G74G|CYBASC3_uc009ynn.2_Intron|CYBASC3_uc001nrh.2_Silent_p.G74G|CYBASC3_uc001nri.2_RNA|CYBASC3_uc009yno.2_Silent_p.G74G	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	74	Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						GCAGTTTGGGCCCCACCCACG	0.607			NA											13	53					0	0	0.00499	0	0
GANAB	23193	broad.mit.edu	37	11	62398602	62398602	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:62398602C>A	uc001nub.2	-	10	1083	c.1050G>T	c.(1048-1050)CAG>CAT	p.Q350H	GANAB_uc001nua.2_Missense_Mutation_p.Q372H|GANAB_uc001nuc.2_Missense_Mutation_p.Q253H|GANAB_uc010rma.1_Missense_Mutation_p.Q258H|GANAB_uc010rmb.1_Missense_Mutation_p.Q236H	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	350					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GAACATCTGTCTGTGGGGTCT	0.547	Melanoma(23;1005 1074 15747 18937)		NA											110	323					1.22493e-33	1.96864e-33	0.00361	1	0
NXF1	10482	broad.mit.edu	37	11	62569274	62569274	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:62569274G>A	uc001nvf.1	-	6	712	c.576C>T	c.(574-576)AAC>AAT	p.N192N	NXF1_uc001nvg.1_Silent_p.N192N|NXF1_uc009yog.1_Silent_p.N235N|NXF1_uc010rmh.1_Silent_p.N55N	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	192	Interaction with THOC4.|RRM.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						GAGCAGAAGAGTTGATGATGA	0.488			NA											40	224					0	0	0.002852	0	0
SLC22A6	9356	broad.mit.edu	37	11	62749428	62749428	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:62749428T>A	uc001nwk.2	-	4	990	c.683A>T	c.(682-684)TAT>TTT	p.Y228F	SLC22A6_uc001nwl.2_Missense_Mutation_p.Y228F|SLC22A6_uc001nwj.2_Missense_Mutation_p.Y228F|SLC22A6_uc001nwm.2_Missense_Mutation_p.Y228F	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	228	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GCTGTAGACATAGCCAATCAA	0.592			NA											17	68					0	0	0.007413	0	0
PACS1	55690	broad.mit.edu	37	11	66001697	66001697	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:66001697G>A	uc001oha.1	+	17	2222	c.2088G>A	c.(2086-2088)TCG>TCA	p.S696S	PACS1_uc010rou.1_Silent_p.S232S	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	696					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TCAGTCGCTCGGAGCCACCAG	0.567			NA											22	136					0	0	0.00278	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74899193	74899193	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:74899193C>A	uc001owb.2	+	8	1372	c.985C>A	c.(985-987)CCC>ACC	p.P329T	SLCO2B1_uc010rrq.1_Missense_Mutation_p.P74T|SLCO2B1_uc010rrr.1_Missense_Mutation_p.P185T|SLCO2B1_uc010rrs.1_Missense_Mutation_p.P213T|SLCO2B1_uc001owc.2_Missense_Mutation_p.P102T|SLCO2B1_uc001owd.2_Missense_Mutation_p.P307T	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	329	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	CAAGGACTCTCCCTCTAAGCA	0.557			NA											59	77					4.13886e-29	6.48762e-29	0.00361	1	0
ODZ4	26011	broad.mit.edu	37	11	78468036	78468036	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:78468036C>A	uc001ozl.3	-	19	3033	c.2570G>T	c.(2569-2571)TGC>TTC	p.C857F		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	857	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTGGAGGCAGCAGTCAGGGTC	0.537			NA											20	23					4.72057e-08	5.52353e-08	0.003954	1	0
SYTL2	54843	broad.mit.edu	37	11	85459316	85459316	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:85459316T>A	uc010rth.1	-	2	528	c.252A>T	c.(250-252)GCA>GCT	p.A84A	SYTL2_uc010rtg.1_Silent_p.A84A|SYTL2_uc010rti.1_Silent_p.A84A|SYTL2_uc010rtj.1_Silent_p.A36A|SYTL2_uc001pbf.3_Silent_p.A84A	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	84					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TCAACTCACCTGCTATCTGGG	0.468			NA											120	233					0	0	0.00361	0	0
FAT3	120114	broad.mit.edu	37	11	92531039	92531039	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:92531039A>T	uc001pdj.3	+	9	4877	c.4860A>T	c.(4858-4860)CTA>CTT	p.L1620L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1620	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AACCGGTCCTAGGCATCATCA	0.428			NA								TCGA Ovarian(4;0.039)			136	253					0	0	0.00361	0	0
HEPHL1	341208	broad.mit.edu	37	11	93821930	93821930	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:93821930G>C	uc001pep.2	+	12	2247	c.2090G>C	c.(2089-2091)AGG>ACG	p.R697T	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	697	Plastocyanin-like 4.|Extracellular (Potential).			R -> G (in Ref. 3; CAE46009).	copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GGTATTTTTAGGGTGTTTTGT	0.488			NA											4	82					0	0	0.001168	0	0
MAML2	84441	broad.mit.edu	37	11	95713012	95713012	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:95713012C>T	uc001pfw.1	-	5	3856	c.2571G>A	c.(2569-2571)ATG>ATA	p.M857I		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	857					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.M857V(1)	CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				ATAATGATGGCATTCTTGTCC	0.413			NA	T	MECT1|CRTC3	salivary gland mucoepidermoid								14	212					0	0	0.004007	0	0
KIAA1377	57562	broad.mit.edu	37	11	101786030	101786030	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:101786030G>T	uc001pgm.2	+	1	285	c.15G>T	c.(13-15)AGG>AGT	p.R5S	ANGPTL5_uc001pgl.2_Intron	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	5							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TGGCGGGGAGGCCCGGAACCC	0.701			NA											13	11					7.07596e-05	7.798e-05	0.006122	1	0
MMP10	4319	broad.mit.edu	37	11	102643716	102643716	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:102643716C>A	uc001phg.1	-	8	1110	c.1088G>T	c.(1087-1089)AGA>ATA	p.R363I		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	363	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CTCATTTCCTCTGATGGCCCA	0.368			NA											25	276					3.00307e-07	3.4725e-07	0.008361	1	0
GRIA4	2893	broad.mit.edu	37	11	105804494	105804494	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:105804494C>A	uc001pix.2	+	14	2539	c.2093C>A	c.(2092-2094)TCA>TAA	p.S698*	GRIA4_uc001piw.2_Nonsense_Mutation_p.S698*|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	698	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TACATGCGATCAGCAGAGCCA	0.408			NA											7	46					5.18039e-06	5.86459e-06	0.00308	1	0
NNMT	4837	broad.mit.edu	37	11	114182861	114182861	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:114182861C>T	uc001por.1	+	5	721	c.457C>T	c.(457-459)CCC>TCC	p.P153S	NNMT_uc001pos.1_Missense_Mutation_p.P153S	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	153					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	GGGGGCCGTCCCCTTACCCCC	0.622			NA											6	115					0	0	0.001984	0	0
NNMT	4837	broad.mit.edu	37	11	114183054	114183054	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:114183054G>T	uc001por.1	+	5	914	c.650G>T	c.(649-651)GGC>GTC	p.G217V	NNMT_uc001pos.1_Missense_Mutation_p.G217V	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	217					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	CTCCCCCTGGGCCGGGAGGCA	0.547			NA											8	72					0.000673444	0.000722264	0.008291	1	0
RBM7	10179	broad.mit.edu	37	11	114276519	114276519	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:114276519G>T	uc001pov.2	+	4	446	c.436G>T	c.(436-438)GTG>TTG	p.V146L	RBM7_uc001pow.2_Missense_Mutation_p.V147L|RBM7_uc001pox.2_Missense_Mutation_p.V26L	NM_016090	NP_057174	Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	146					meiosis		nucleotide binding|protein binding|RNA binding			ovary(2)	2		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		GAGACAAGCAGTGGTAGGTTG	0.323			NA											71	115					2.15109e-50	3.75918e-50	0.00361	1	0
DSCAML1	57453	broad.mit.edu	37	11	117387251	117387251	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:117387251C>A	uc001prh.1	-	8	1896	c.1894G>T	c.(1894-1896)GAG>TAG	p.E632*		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	572	Extracellular (Potential).|Ig-like C2-type 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACAGGTACTCCCCCTCATCC	0.612			NA											12	19					4.3838e-07	5.05823e-07	0.001855	1	0
OR4D5	219875	broad.mit.edu	37	11	123810656	123810656	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:123810656G>T	uc001pzk.1	+	1	333	c.333G>T	c.(331-333)AAG>AAT	p.K111N		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GAGGCATCAAGATCTTCCTGC	0.498			NA											155	239					4.71032e-111	9.05186e-111	0.00361	1	0
OR10S1	219873	broad.mit.edu	37	11	123848123	123848123	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:123848123G>T	uc001pzm.1	-	1	276	c.276C>A	c.(274-276)CCC>CCA	p.P92P		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P92L(1)		ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCATGACCTTGGGCACTGTCA	0.547			NA											16	275					3.62473e-10	4.41343e-10	0.001882	1	0
VWA5A	4013	broad.mit.edu	37	11	124007382	124007382	+	Splice_Site	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:124007382G>C	uc001pzu.2	+	14	1834	c.1625_splice	c.e14+1	p.N542_splice	VWA5A_uc001pzt.2_Splice_Site_p.N542_splice	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2						CTGATGTCAAGTGAGAATTCA	0.254			NA											30	306					0	0	0.00623	0	0
OR8B12	219858	broad.mit.edu	37	11	124413479	124413479	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:124413479G>T	uc010sam.1	-	1	72	c.72C>A	c.(70-72)ATC>ATA	p.I24I		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AGAAGAGGGGGATCCGCAGTC	0.547			NA											124	173					2.42353e-96	4.64081e-96	0.00361	1	0
PKNOX2	63876	broad.mit.edu	37	11	125299921	125299921	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:125299921C>A	uc001qbu.2	+	12	1390	c.1076C>A	c.(1075-1077)GCC>GAC	p.A359D	PKNOX2_uc010saz.1_Missense_Mutation_p.A330D|PKNOX2_uc010sba.1_Missense_Mutation_p.A330D|PKNOX2_uc010sbb.1_Missense_Mutation_p.A295D|PKNOX2_uc001qbv.2_Missense_Mutation_p.A124D	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	359						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CCAGATCCTGCCCCCAAAGCC	0.607			NA											25	219					3.73148e-12	4.75796e-12	0.007291	1	0
KIRREL3	84623	broad.mit.edu	37	11	126306857	126306857	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:126306857G>A	uc001qea.2	-	12	1762	c.1401C>T	c.(1399-1401)CGC>CGT	p.R467R	KIRREL3_uc001qeb.2_Silent_p.R467R|KIRREL3_uc001qec.1_Silent_p.R467R|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	467	Extracellular (Potential).|Ig-like C2-type 5.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CCACCGTATAGCGCCCCGATG	0.642			NA											6	17					0	0	0.001984	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130340820	130340820	+	Missense_Mutation	SNP	G	G	A	rs147190472		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:130340820G>A	uc010scd.1	+	6	1726	c.1726G>A	c.(1726-1728)GGA>AGA	p.G576R		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	576	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCTAGCCTCCGGAAAGAGCTT	0.602			NA											6	104					0	0	0.001168	0	0
GLB1L2	89944	broad.mit.edu	37	11	134239735	134239735	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:134239735C>T	uc001qhp.2	+	11	1252	c.1064C>T	c.(1063-1065)ACG>ATG	p.T355M	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	355					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GGCGATTACACGGCCAAGTAC	0.552			NA											4	149					0	0	0.009096	0	0
DYRK4	8798	broad.mit.edu	37	12	4722693	4722693	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:4722693A>G	uc001qmx.2	+	13	1497	c.1337A>G	c.(1336-1338)AAA>AGA	p.K446R	DYRK4_uc001qmy.1_Missense_Mutation_p.K445R|DYRK4_uc001qmz.1_Missense_Mutation_p.K159R|DYRK4_uc001qna.1_Missense_Mutation_p.K82R|DYRK4_uc010ser.1_Missense_Mutation_p.K83R	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	446						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GAGATCACCAAAGAGACTACA	0.438			NA											21	131					0	0	0.00333	0	0
VWF	7450	broad.mit.edu	37	12	6135206	6135206	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:6135206C>A	uc001qnn.1	-	23	3224	c.2974G>T	c.(2974-2976)GTG>TTG	p.V992L	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	992	VWFD 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AGGCCACACACTTTCTCCTTG	0.557			NA											34	196					3.61848e-18	5.10177e-18	0.007835	1	0
ACRBP	84519	broad.mit.edu	37	12	6756063	6756063	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:6756063G>T	uc001qpu.1	-	2	207	c.159C>A	c.(157-159)ACC>ACA	p.T53T	ACRBP_uc010sfg.1_Silent_p.T53T	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	53						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CTGCCTTCCAGGTTGGAGTCA	0.607			NA											10	29					2.68362e-12	3.4259e-12	0.001368	1	0
LRRC23	10233	broad.mit.edu	37	12	7015720	7015720	+	Silent	SNP	C	C	T	rs116689978	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:7015720C>T	uc001qrt.3	+	4	776	c.384C>T	c.(382-384)GCC>GCT	p.A128A	LRRC23_uc001qrn.1_Silent_p.A128A|LRRC23_uc009zfg.2_RNA|LRRC23_uc001qrp.2_Silent_p.A128A|LRRC23_uc001qrq.2_Silent_p.A128A|LRRC23_uc001qrr.2_Silent_p.A77A|LRRC23_uc001qrs.2_Silent_p.A77A|LRRC23_uc009zfh.2_Silent_p.A128A	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	128	LRR 2.									ovary(1)	1						TGCGAAGTGCCCAGATGAATG	0.493			NA											7	421					0	0	0.00308	0	0
CD163	9332	broad.mit.edu	37	12	7636091	7636092	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:7636091_7636092CC>AA	uc001qsz.3	-	12	3087_3088	c.2959_2960GG>TT	c.(2959-2961)GGG>TTG	p.G987L	CD163_uc001qta.3_Missense_Mutation_p.G987L|CD163_uc009zfw.2_Missense_Mutation_p.G1020L	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	987	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CGGTCCAGTCCCCTGACCAAAC	0.52			NA											49	147					0	0	0.004672	0	0
PZP	5858	broad.mit.edu	37	12	9317736	9317736	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:9317736C>T	uc001qvl.2	-	19	2515	c.2486G>A	c.(2485-2487)CGG>CAG	p.R829Q	PZP_uc009zgl.2_Missense_Mutation_p.R698Q|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Missense_Mutation_p.R161Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTCCTTACCCGGATGCATTT	0.463	Melanoma(125;1402 1695 4685 34487 38571)		NA											5	356					0	0	0.00308	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214101	11214101	+	Missense_Mutation	SNP	C	C	T	rs147671448	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:11214101C>T	uc001qzp.1	-	1	793	c.793G>A	c.(793-795)GAA>AAA	p.E265K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	265	Helical; Name=7; (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GCAATAGCTTCGCAGAACATG	0.418			NA											17	663					0	0	0.008871	0	0
ABCC9	10060	broad.mit.edu	37	12	22089557	22089557	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:22089557C>G	uc001rfi.1	-	1	72	c.52G>C	c.(52-54)GGT>CGT	p.G18R	ABCC9_uc001rfh.2_Missense_Mutation_p.G18R|ABCC9_uc001rfj.1_Missense_Mutation_p.G18R|ABCC9_uc001rfk.2_Missense_Mutation_p.G18R|ABCC9_uc001rfl.1_Missense_Mutation_p.G18R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	18	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGTAGTACACCATCGTTGATA	0.338			NA											23	120					0	0	0.00333	0	0
SOX5	6660	broad.mit.edu	37	12	23999036	23999036	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:23999036C>A	uc001rfw.2	-	3	464	c.362G>T	c.(361-363)GGC>GTC	p.G121V	SOX5_uc001rfx.2_Missense_Mutation_p.G108V|SOX5_uc001rfy.2_Missense_Mutation_p.G108V|SOX5_uc010siv.1_Missense_Mutation_p.G108V|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.G73V|SOX5_uc001rga.2_Missense_Mutation_p.G86V	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	121					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CAAGGACTCGCCACTCTGTCG	0.498			NA											15	147					9.16793e-09	1.08926e-08	0.00499	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27787877	27787877	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:27787877T>C	uc001ric.1	+	4	476	c.99T>C	c.(97-99)TTT>TTC	p.F33F	PPFIBP1_uc001rhy.1_Silent_p.F33F|PPFIBP1_uc001rhz.1_Silent_p.F33F|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Silent_p.F33F|PPFIBP1_uc001ria.2_Silent_p.F33F|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	33					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ATGGGATTTTTGATTGCCAAT	0.418			NA											6	255					0	0	0.00308	0	0
IPO8	10526	broad.mit.edu	37	12	30783888	30783888	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:30783888G>T	uc001rjd.2	-	25	3190	c.3020C>A	c.(3019-3021)GCA>GAA	p.A1007E	IPO8_uc001rje.1_3'UTR|IPO8_uc010sjt.1_Missense_Mutation_p.A802E	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	1007					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CTTCTTCTTTGCCTCTAGCAT	0.398			NA											42	91					8.69298e-16	1.17063e-15	0.006999	1	0
IPO8	10526	broad.mit.edu	37	12	30837234	30837234	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:30837234C>A	uc001rjd.2	-	3	493	c.323_splice	c.e3+1	p.R108_splice		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8						intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GCACCACATACCTCACTAAAT	0.398			NA											66	168					5.04879e-28	7.83432e-28	0.00361	1	0
Unknown	0	broad.mit.edu	37	12	31292033	31292033	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:31292033C>T	uc010sjy.1	-	14	1936	c.1936G>A	c.(1936-1938)GAT>AAT	p.D646N						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						ATATCTCCATCCCCATAGTTG	0.348			NA											29	155					0	0	0.00361	0	0
BICD1	636	broad.mit.edu	37	12	32260458	32260458	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:32260458G>C	uc001rku.2	+	1	274	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	BICD1_uc001rkv.2_Missense_Mutation_p.E65Q|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	65	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CCTCAAACAGGAGCTGGAGCA	0.577			NA											2	7					0	0	0.009096	0	0
YARS2	51067	broad.mit.edu	37	12	32908775	32908775	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:32908775C>A	uc001rli.2	-	1	100	c.34G>T	c.(34-36)GGC>TGC	p.G12C		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	12					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	GACCACCGGCCCCAGGAAAAG	0.612			NA									OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	19					1.3612e-06	1.55074e-06	0.003163	1	0
ANO6	196527	broad.mit.edu	37	12	45810526	45810526	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:45810526C>T	uc001roo.2	+	17	2391	c.2056C>T	c.(2056-2058)CTG>TTG	p.L686L	ANO6_uc010sld.1_Silent_p.L686L|ANO6_uc010sle.1_Silent_p.L686L|ANO6_uc010slf.1_Silent_p.L707L|ANO6_uc010slg.1_Silent_p.L668L	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	686	Helical; (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						CTCTTTTCCACTGGCCCCTCT	0.473			NA											113	150					0	0	0.00361	0	0
ARID2	196528	broad.mit.edu	37	12	46233207	46233207	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:46233207C>T	uc001ros.1	+	11	1426	c.1426C>T	c.(1426-1428)CAA>TAA	p.Q476*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q476*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q103*|ARID2_uc001rot.1_Nonsense_Mutation_p.Q122*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	476					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCCAGTCATCAAATGTTATC	0.413			NA											8	496					0	0	0.00308	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46320773	46320773	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:46320773C>A	uc001rox.2	-	11	2998	c.2711G>T	c.(2710-2712)GGA>GTA	p.G904V	SFRS2IP_uc001row.2_Missense_Mutation_p.G589V|SFRS2IP_uc001roy.1_Missense_Mutation_p.G978V	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	904	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GGATTTTTCTCCTGGGGAAGA	0.458			NA											126	159					1.06126e-43	1.81642e-43	0.00361	1	0
RAPGEF3	10411	broad.mit.edu	37	12	48143570	48143570	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:48143570C>A	uc009zkp.2	-	8	1162	c.722G>T	c.(721-723)TGG>TTG	p.W241L	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.W241L|RAPGEF3_uc001rpz.3_Missense_Mutation_p.W283L|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.W295L|RAPGEF3_uc001rqb.3_Missense_Mutation_p.W283L	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	241					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GATAATGTACCACGAAGTGCC	0.592			NA											27	31					1.39806e-14	1.83686e-14	0.008361	1	0
ADCY6	112	broad.mit.edu	37	12	49170251	49170251	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:49170251C>A	uc001rsh.3	-	6	2155	c.1495G>T	c.(1495-1497)GTG>TTG	p.V499L	ADCY6_uc001rsj.3_Missense_Mutation_p.V499L|ADCY6_uc001rsi.3_Missense_Mutation_p.V499L|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	499	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GCCAGGGTCACATCATTGGAC	0.647			NA											16	40					0.000566183	0.000612703	0.00499	1	0
LETMD1	25875	broad.mit.edu	37	12	51442900	51442900	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:51442900G>T	uc001rxm.2	+	2	262	c.206G>T	c.(205-207)GGG>GTG	p.G69V	LETMD1_uc010smz.1_Missense_Mutation_p.G69V|LETMD1_uc010sna.1_Missense_Mutation_p.G69V|LETMD1_uc001rxl.2_Missense_Mutation_p.G13V|LETMD1_uc009zlv.2_RNA|LETMD1_uc001rxs.2_Missense_Mutation_p.G69V|LETMD1_uc009zlw.2_Missense_Mutation_p.G69V|LETMD1_uc001rxn.2_5'UTR|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Intron|LETMD1_uc001rxq.2_Missense_Mutation_p.G69V|LETMD1_uc001rxr.2_RNA|LETMD1_uc001rxt.2_5'UTR	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	69	Cytoplasmic (Potential).|Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						GCGATTAATGGGAAATACCAT	0.398			NA											41	64					4.17328e-34	6.72708e-34	0.00361	1	0
BIN2	51411	broad.mit.edu	37	12	51689596	51689596	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:51689596C>G	uc001ryg.2	-	9	797	c.745G>C	c.(745-747)GTG>CTG	p.V249L	BIN2_uc009zlz.2_Missense_Mutation_p.V217L|BIN2_uc001ryh.2_Missense_Mutation_p.V125L|BIN2_uc010sng.1_Missense_Mutation_p.V223L	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	249						cytoplasm	protein binding			ovary(1)	1						AGTCCCTTCACCACAAAGACT	0.453			NA											122	250					0	0	0.00361	0	0
KRT6A	3853	broad.mit.edu	37	12	52885477	52885477	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:52885477C>A	uc001sam.2	-	2	793	c.584G>T	c.(583-585)TGG>TTG	p.W195L		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	195	Coil 1A.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGCAGGGTCCACTTTGTTTC	0.522			NA											29	42					2.84144e-21	4.13578e-21	0.00361	1	0
KRT5	3852	broad.mit.edu	37	12	52910579	52910579	+	Silent	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:52910579A>G	uc001san.2	-	7	1444	c.1281T>C	c.(1279-1281)GAT>GAC	p.D427D	KRT5_uc009zmh.2_Silent_p.D427D	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	427	Rod.|Coil 2.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTTCCTGGCATCCTTGAGGG	0.617			NA											108	146					0	0	0.00361	0	0
SOAT2	8435	broad.mit.edu	37	12	53515143	53515143	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:53515143C>T	uc001sbv.2	+	12	1282	c.1194C>T	c.(1192-1194)GTC>GTT	p.V398V	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	398					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						ACGTGGTGGTCCATGACTGGC	0.567			NA											8	140					0	0	0.008291	0	0
ZNF385A	25946	broad.mit.edu	37	12	54767848	54767848	+	Silent	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:54767848G>C	uc001sfw.1	-	3	453	c.270C>G	c.(268-270)ACC>ACG	p.T90T	ZNF385A_uc001sfv.1_Silent_p.T71T|ZNF385A_uc009zno.1_RNA|ZNF385A_uc010sov.1_Silent_p.T90T|ZNF385A_uc001sfx.1_Silent_p.T90T|ZNF385A_uc001sfy.3_Silent_p.T110T|ZNF385A_uc001sfz.3_Silent_p.T110T	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CCCTGCCTCTGGTCTTGGCAG	0.597			NA											12	22					0	0	0.007413	0	0
KIAA0748	9840	broad.mit.edu	37	12	55356793	55356793	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:55356793G>A	uc001sgn.3	-	9	999	c.889C>T	c.(889-891)CGA>TGA	p.R297*	KIAA0748_uc001sgl.3_Nonsense_Mutation_p.R159*|KIAA0748_uc001sgm.3_Nonsense_Mutation_p.R44*|KIAA0748_uc010spb.1_Nonsense_Mutation_p.R44*|KIAA0748_uc010spc.1_Nonsense_Mutation_p.R159*|KIAA0748_uc010spd.1_Nonsense_Mutation_p.R297*|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	297										ovary(1)|central_nervous_system(1)	2						GGCCGGTCTCGGGGGCATGTG	0.542			NA											97	145					0	0	0.00361	0	0
OR6C6	283365	broad.mit.edu	37	12	55688351	55688351	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:55688351G>T	uc010sph.1	-	1	666	c.666C>A	c.(664-666)ACC>ACA	p.T222T		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						ATTTCAGAATGGTCTTAATAA	0.398			NA											8	391					1.12685e-05	1.26376e-05	0.004482	1	0
OR6C1	390321	broad.mit.edu	37	12	55714510	55714510	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:55714510C>A	uc010spi.1	+	1	127	c.127C>A	c.(127-129)CTT>ATT	p.L43I		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						GAACCTGACCCTTATCACAAT	0.423			NA											66	85					2.23399e-28	3.48155e-28	0.00361	1	0
TIMELESS	8914	broad.mit.edu	37	12	56811918	56811918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:56811918C>A	uc001slf.2	-	27	3622	c.3454G>T	c.(3454-3456)GAG>TAG	p.E1152*		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	1152					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GCACTATTACCCTCTGGGGAT	0.532			NA											112	172					7.55469e-51	1.32238e-50	0.00361	1	0
RDH16	8608	broad.mit.edu	37	12	57345827	57345827	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:57345827C>A	uc001smi.3	-	4	1112	c.940G>T	c.(940-942)GCC>TCC	p.A314S	RDH16_uc009zpa.2_Missense_Mutation_p.A169S	NM_003708	NP_003699	O75452	RDH16_HUMAN	retinol dehydrogenase 16	314	Lumenal (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity				0						AGAGCCTTGGCCGGGCTTGGA	0.537	GBM(179;741 2921 43105 45298)		NA											34	46					8.16277e-20	1.16611e-19	0.006999	1	0
TPH2	121278	broad.mit.edu	37	12	72416181	72416181	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:72416181C>G	uc009zrw.1	+	9	1212	c.1071C>G	c.(1069-1071)TGC>TGG	p.C357W	TPH2_uc001swy.2_Missense_Mutation_p.C267W	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	357					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	TTCTTCAGTGCTATTTCTTCA	0.413			NA											10	270					0	0	0.001368	0	0
PHLDA1	22822	broad.mit.edu	37	12	76424788	76424788	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:76424788C>A	uc001sxu.2	-	1	769	c.734G>T	c.(733-735)CGC>CTC	p.R245L		NM_007350	NP_031376	Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A,	245	PH.				apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding				0		Colorectal(145;0.09)				CTTGCCCTTGCGCTCCACACA	0.612			NA											39	39					4.14194e-30	6.54947e-30	0.002852	1	0
EPYC	1833	broad.mit.edu	37	12	91358003	91358003	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:91358003G>T	uc001tbk.2	-	7	992	c.899C>A	c.(898-900)CCT>CAT	p.P300H		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	300	LRR 6.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						GAGATTAATAGGGTTTCCATC	0.393			NA											41	59					3.70713e-34	5.98461e-34	0.00361	1	0
CCDC63	160762	broad.mit.edu	37	12	111336809	111336809	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:111336809G>T	uc001trv.1	+	10	1417	c.1222G>T	c.(1222-1224)GAT>TAT	p.D408Y	CCDC63_uc010sye.1_Missense_Mutation_p.D368Y|CCDC63_uc001trw.1_Missense_Mutation_p.D323Y	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	408	Potential.									skin(6)|ovary(1)|pancreas(1)	8						CAAGACCTTGGATCTATTGAA	0.507			NA											82	81					1.13884e-41	1.9218e-41	0.00361	1	0
TBX5	6910	broad.mit.edu	37	12	114804114	114804114	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:114804114C>T	uc001tvo.2	-	8	1333	c.838G>A	c.(838-840)GCT>ACT	p.A280T	TBX5_uc001tvp.2_Missense_Mutation_p.A280T|TBX5_uc001tvq.2_Missense_Mutation_p.A230T|TBX5_uc010syv.1_Missense_Mutation_p.A280T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	280					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GTGGAGAGAGCTCGAGACTCG	0.552	NSCLC(152;1358 1980 4050 23898 40356)		NA											21	224					0	0	0.002299	0	0
TBX3	6926	broad.mit.edu	37	12	115114148	115114148	+	Missense_Mutation	SNP	C	C	A	rs140580685	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:115114148C>A	uc001tvt.1	-	6	2033	c.1069G>T	c.(1069-1071)GCC>TCC	p.A357S	TBX3_uc001tvu.1_Missense_Mutation_p.A337S	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	357					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		ACAGTGGAGGCGGCTGGAGAA	0.522			NA											39	33					5.2432e-18	7.36367e-18	0.00361	1	0
NOS1	4842	broad.mit.edu	37	12	117718572	117718572	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:117718572G>A	uc001twm.1	-	8	2168	c.1482C>T	c.(1480-1482)GAC>GAT	p.D494D		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	494					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGGTGGAGCCGTCAGGCTGCT	0.617	Esophageal Squamous(162;1748 2599 51982 52956)		NA											8	79					0	0	0.006214	0	0
CIT	11113	broad.mit.edu	37	12	120263085	120263085	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:120263085C>A	uc001txi.1	-	8	894	c.841G>T	c.(841-843)GGC>TGC	p.G281C	CIT_uc001txj.1_Missense_Mutation_p.G281C	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	281	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAGTCCAGGCCGTAGGTGCCT	0.527			NA											124	170					1.7381e-60	3.15487e-60	0.00361	1	0
RNF17	56163	broad.mit.edu	37	13	25356050	25356050	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:25356050G>A	uc001upr.2	+	6	620	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	RNF17_uc010tdd.1_Silent_p.Q52Q|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.Q193Q|RNF17_uc001ups.2_Silent_p.Q132Q|RNF17_uc001upq.1_Silent_p.Q193Q	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	193					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TGGAGAAACAGTTTGACCAAC	0.328			NA											36	200					0	0	0.00361	0	0
NUPL1	9818	broad.mit.edu	37	13	25881957	25881957	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:25881957G>T	uc001uqi.2	+	2	367	c.121G>T	c.(121-123)GGG>TGG	p.G41W	NUPL1_uc001uqg.1_Missense_Mutation_p.G41W|NUPL1_uc001uqj.2_Missense_Mutation_p.G41W	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	41	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		CCCTTCTGTGGGGCTCAATTT	0.378	Pancreas(166;1040 2004 4560 4728 37041)|GBM(109;1045 1520 7614 9308 19618)		NA											12	51					9.05144e-12	1.14067e-11	0.001855	1	0
KATNAL1	84056	broad.mit.edu	37	13	30801606	30801606	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:30801606T>C	uc001uss.2	-	9	1191	c.1090A>G	c.(1090-1092)ATT>GTT	p.I364V	KATNAL1_uc001ust.2_Missense_Mutation_p.I364V	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	364						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		GCTTCATCAATGTCCCACGGG	0.378			NA											72	394					0	0	0.00361	0	0
HSPH1	10808	broad.mit.edu	37	13	31713001	31713001	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:31713001C>T	uc001utj.2	-	16	2523	c.2125G>A	c.(2125-2127)GCT>ACT	p.A709T	HSPH1_uc001utk.2_Missense_Mutation_p.A665T|HSPH1_uc010aaw.2_Missense_Mutation_p.A668T|HSPH1_uc001utl.2_Missense_Mutation_p.A711T|HSPH1_uc010tds.1_Missense_Mutation_p.A633T	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	709					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CGTTCTTCAGCTTCCTGAAAC	0.313			NA											17	139					0	0	0.001882	0	0
FRY	10129	broad.mit.edu	37	13	32811626	32811626	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:32811626A>T	uc001utx.2	+	44	6417	c.5921A>T	c.(5920-5922)GAA>GTA	p.E1974V	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCAACTGCCGAACGGAGCCGG	0.532			NA											6	50					0	0	0.008291	0	0
PDS5B	23047	broad.mit.edu	37	13	33320130	33320130	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:33320130A>T	uc010abf.2	+	24	2786	c.2628A>T	c.(2626-2628)TCA>TCT	p.S876S	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	876					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CAGATATGTCACGTCTGAGAC	0.328			NA											21	266					0	0	0.008361	0	0
STARD13	90627	broad.mit.edu	37	13	33703975	33703975	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:33703975C>A	uc001uuw.2	-	5	965	c.839G>T	c.(838-840)CGG>CTG	p.R280L	STARD13_uc001uuu.2_Missense_Mutation_p.R272L|STARD13_uc001uuv.2_Missense_Mutation_p.R162L|STARD13_uc001uux.2_Missense_Mutation_p.R245L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.R265L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	280					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GCCACCTGTCCGCCCAGACCC	0.542			NA											17	189					7.07596e-05	7.798e-05	0.006122	1	0
STARD13	90627	broad.mit.edu	37	13	33704350	33704350	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:33704350C>A	uc001uuw.2	-	5	590	c.464G>T	c.(463-465)CGT>CTT	p.R155L	STARD13_uc001uuu.2_Missense_Mutation_p.R147L|STARD13_uc001uuv.2_Missense_Mutation_p.R37L|STARD13_uc001uux.2_Missense_Mutation_p.R120L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.R140L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	155					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GTCGTCCACACGAGACCACCT	0.552			NA											20	140					1.12875e-08	1.33815e-08	0.00632	1	0
RFC3	5983	broad.mit.edu	37	13	34404943	34404943	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:34404943A>T	uc001uuz.2	+	6	771	c.661A>T	c.(661-663)AGA>TGA	p.R221*	RFC3_uc001uva.2_Nonsense_Mutation_p.R221*|RFC3_uc010ted.1_Nonsense_Mutation_p.R221*	NM_002915	NP_002906	P40938	RFC3_HUMAN	replication factor C 3 isoform 1	221					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding				0		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		GAAGTCTTGTAGAAATCTCAG	0.383			NA											23	125					0	0	0.002096	0	0
NBEA	26960	broad.mit.edu	37	13	35733541	35733541	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:35733541C>A	uc001uvb.2	+	23	3439	c.3233C>A	c.(3232-3234)CCG>CAG	p.P1078Q	NBEA_uc010abi.2_5'Flank	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1078						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GATTTATCACCGGAGACTTTA	0.403			NA											11	85					2.31682e-05	2.57425e-05	0.003163	1	0
ELF1	1997	broad.mit.edu	37	13	41507884	41507884	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:41507884G>C	uc001uxs.2	-	9	1910	c.1537C>G	c.(1537-1539)CAG>GAG	p.Q513E	ELF1_uc010tfc.1_Missense_Mutation_p.Q489E|ELF1_uc010acd.2_Missense_Mutation_p.Q406E	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	513					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CAAATGGTCTGAACATTGCTA	0.517			NA											18	142					0	0	0.006122	0	0
PCDH17	27253	broad.mit.edu	37	13	58209184	58209184	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:58209184G>C	uc001vhq.1	+	1	3396	c.2504G>C	c.(2503-2505)AGC>ACC	p.S835T	PCDH17_uc010aec.1_Missense_Mutation_p.S835T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	835	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGCCACACCAGCTTCACCGGA	0.577	Melanoma(72;952 1291 1619 12849 33676)		NA											4	22					0	0	0.009096	0	0
KLHL1	57626	broad.mit.edu	37	13	70314575	70314575	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:70314575T>A	uc001vip.2	-	8	2547	c.1753A>T	c.(1753-1755)AGT>TGT	p.S585C	KLHL1_uc010thm.1_Missense_Mutation_p.S524C	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	585	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ATTGACATACTGGCTACAAAT	0.403			NA											23	160					0	0	0.005443	0	0
C13orf34	79866	broad.mit.edu	37	13	73319235	73319235	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:73319235T>A	uc001viv.1	+	8	747	c.628T>A	c.(628-630)TCG>ACG	p.S210T	C13orf34_uc010thq.1_5'UTR|C13orf34_uc010aen.1_Missense_Mutation_p.S285T|C13orf34_uc010thr.1_Missense_Mutation_p.S140T|C13orf34_uc001viw.1_Missense_Mutation_p.S159T	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	210	Ser-rich.				cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		CTCCTTACCTTCGGCTTCTCC	0.448			NA											25	207					0	0	0.005524	0	0
UCHL3	7347	broad.mit.edu	37	13	76134927	76134927	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:76134927C>T	uc001vjq.2	+	3	123	c.93C>T	c.(91-93)TTC>TTT	p.F31F	UCHL3_uc001vjr.2_5'UTR	NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	31					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		ACTGGCAATTCGTTGATGTAT	0.338			NA											5	197					0	0	0.001984	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369289	86369289	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:86369289G>T	uc001vll.1	-	2	1814	c.1355C>A	c.(1354-1356)CCA>CAA	p.P452Q	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	452	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AAAGGTTCCTGGCAGTATTTC	0.358			NA											14	106					2.48551e-13	3.2225e-13	0.00499	1	0
GPC5	2262	broad.mit.edu	37	13	92101100	92101100	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:92101100G>T	uc010tif.1	+	2	615	c.249G>T	c.(247-249)CAG>CAT	p.Q83H		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	83						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CGGCTCGCCAGGATATGCAGC	0.438			NA											53	276					7.22619e-39	1.20436e-38	0.00361	1	0
SLC10A2	6555	broad.mit.edu	37	13	103718254	103718254	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:103718254C>A	uc001vpy.3	-	1	943	c.346G>T	c.(346-348)GCC>TCC	p.A116S		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	116	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACCCAATAGGCCAAGATATTG	0.507			NA											23	270					8.24728e-16	1.11338e-15	0.004656	1	0
LIG4	3981	broad.mit.edu	37	13	108861585	108861585	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:108861585G>A	uc001vqn.2	-	2	2305	c.2032C>T	c.(2032-2034)CTG>TTG	p.L678L	LIG4_uc001vqo.2_Silent_p.L678L|LIG4_uc010agg.1_Silent_p.L611L|LIG4_uc010agf.2_Silent_p.L678L|LIG4_uc001vqp.2_Silent_p.L678L	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	678	BRCT 1.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTGTTCTCCAGGTCAGGCTTT	0.383			NA						NHEJ					8	26					0	0	0.008291	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114107681	114107681	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:114107681C>T	uc001vtq.1	-	1	159	c.72G>A	c.(70-72)AAG>AAA	p.K24K		NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	24					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			TGCTGTTCTCCTTGCAGACAT	0.577			NA											18	66					0	0	0.001882	0	0
OR4L1	122742	broad.mit.edu	37	14	20528425	20528425	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:20528425C>T	uc001vwn.1	+	1	222	c.222C>T	c.(220-222)TCC>TCT	p.S74S		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGTGTCTCTCCACTGCCACAA	0.453			NA											49	392					0	0	0.00361	0	0
RNASE2	6036	broad.mit.edu	37	14	21424254	21424254	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:21424254C>A	uc010aif.2	+	2	393	c.324C>A	c.(322-324)ATC>ATA	p.I108I	RNASE2_uc001vyl.1_Silent_p.I108I	NM_002934	NP_002925	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver,	108					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		TGCCTTTAATCCACTGTAACC	0.418			NA											69	363					6.00099e-30	9.44762e-30	0.00361	1	0
NDRG2	57447	broad.mit.edu	37	14	21486634	21486634	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:21486634G>T	uc001vyy.2	-	14	993	c.843C>A	c.(841-843)ACC>ACA	p.T281T	NDRG2_uc010tll.1_Silent_p.T277T|NDRG2_uc001vyt.2_Silent_p.T194T|NDRG2_uc001vyu.2_Silent_p.T238T|NDRG2_uc001vyv.2_Silent_p.T267T|NDRG2_uc001vyw.2_Silent_p.T267T|NDRG2_uc001vzb.2_Silent_p.T221T|NDRG2_uc001vyx.2_Silent_p.T281T|NDRG2_uc001vza.2_Silent_p.T267T|NDRG2_uc001vyz.2_Silent_p.T267T|NDRG2_uc001vzc.2_Intron|NDRG2_uc001vze.2_Silent_p.T281T|NDRG2_uc001vzd.2_Silent_p.T281T|NDRG2_uc001vzg.2_Silent_p.T267T|NDRG2_uc001vzf.2_Silent_p.T267T|NDRG2_uc010aig.2_Silent_p.T270T	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	281					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACGAGGTCTGGGTGGGGTCCA	0.582			NA											14	33					9.16793e-09	1.08926e-08	0.00499	1	0
Unknown	0	broad.mit.edu	37	14	22337510	22337510	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:22337510C>A	uc010tmf.1	+	2	383	c.304C>A	c.(304-306)CCT>ACT	p.P102T	uc001wbw.2_Intron|uc010tmg.1_Intron|uc010tmh.1_Missense_Mutation_p.P101T|uc001wby.2_Intron					SubName: Full=Putative uncharacterized protein ENSP00000374943;												NA						AGAGACCCAACCTGAAGACTC	0.493			NA											101	260					1.2656e-43	2.15932e-43	0.00361	1	0
NYNRIN	57523	broad.mit.edu	37	14	24877306	24877306	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:24877306G>T	uc001wpf.3	+	3	748	c.430G>T	c.(430-432)GGC>TGC	p.G144C		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	144					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						ACTGCGCTGGGGCCCTGCCCC	0.687			NA											5	19					0.00116845	0.00123961	0.001168	1	0
GZMH	2999	broad.mit.edu	37	14	25075914	25075914	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:25075914G>T	uc001wpr.1	-	5	681	c.636C>A	c.(634-636)GCC>GCA	p.A212A	GZMH_uc010aly.1_Silent_p.A126A|GZMH_uc010alz.1_3'UTR	NM_033423	NP_219491	P20718	GRAH_HUMAN	granzyme H precursor	212	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(265;0.0267)		GAATACCTTGGGCTACGTCCT	0.532			NA											24	122					1.06647e-15	1.4308e-15	0.003755	1	0
PRKD1	5587	broad.mit.edu	37	14	30133065	30133065	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:30133065C>A	uc001wqh.2	-	4	717	c.536G>T	c.(535-537)GGG>GTG	p.G179V		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	179	Phorbol-ester/DAG-type 1.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CAGACCACACCCTGGAAAGGG	0.358			NA											54	163					9.87224e-16	1.32777e-15	0.00361	1	0
HEATR5A	25938	broad.mit.edu	37	14	31778370	31778370	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:31778370G>T	uc001wrf.3	-	23	3658	c.3581C>A	c.(3580-3582)GCA>GAA	p.A1194E	HEATR5A_uc010ami.2_Missense_Mutation_p.A1092E	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1481							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		ACTAGTCTCTGCTGTGTAGAA	0.343			NA											42	159					3.68337e-26	5.63462e-26	0.00361	1	0
AKAP6	9472	broad.mit.edu	37	14	33015542	33015542	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:33015542T>C	uc001wrq.2	+	4	1853	c.1683T>C	c.(1681-1683)AGT>AGC	p.S561S	AKAP6_uc010aml.2_Silent_p.S558S	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	561					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATCAGAGAAGTTGGAATGCCA	0.458	Melanoma(49;821 1200 7288 13647 42351)		NA											7	424					0	0	0.00308	0	0
EXOC5	10640	broad.mit.edu	37	14	57684713	57684713	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:57684713T>G	uc001xct.2	-	15	1851	c.1600A>C	c.(1600-1602)ACT>CCT	p.T534P	EXOC5_uc001xcs.2_Missense_Mutation_p.T213P|EXOC5_uc010trg.1_Missense_Mutation_p.T479P|EXOC5_uc010trh.1_Missense_Mutation_p.T469P	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	534					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						TCAATGCCAGTATCCAATTTC	0.289			NA											17	164					0	0	0.002299	0	0
SLC35F4	341880	broad.mit.edu	37	14	58036699	58036699	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:58036699C>A	uc001xdb.1	-	6	1042	c.1042_splice	c.e6-1	p.V348_splice	SLC35F4_uc010aoz.1_Splice_Site|SLC35F4_uc010apa.1_Splice_Site_p.V189_splice	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TAAACAAGACCTGGAATGAGA	0.433			NA											5	36					0.00116845	0.00123961	0.001168	1	0
RHOJ	57381	broad.mit.edu	37	14	63671738	63671738	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:63671738G>A	uc001xgb.1	+	1	594	c.151G>A	c.(151-153)GTG>ATG	p.V51M		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	51	Effector region (Potential).				actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		AGAGGAATACGTGCCCACTGT	0.557			NA											28	208					0	0	0.006999	0	0
ESR2	2100	broad.mit.edu	37	14	64699947	64699947	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:64699947G>A	uc001xha.1	-	9	1969	c.1501C>T	c.(1501-1503)CGC>TGC	p.R501C	ESR2_uc001xgu.2_Intron|ESR2_uc001xgv.2_Intron|ESR2_uc001xgw.2_Intron|ESR2_uc001xgx.2_Intron|ESR2_uc001xgy.1_Intron|ESR2_uc001xgz.1_3'UTR|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.R410C	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	501	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	TTGCACCCGCGAAGCACGTGG	0.562			NA											10	393					0	0	0.000978	0	0
RAB15	376267	broad.mit.edu	37	14	65417768	65417768	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:65417768C>T	uc001xhz.2	-	4	429	c.348G>A	c.(346-348)CCG>CCA	p.P116P	FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|RAB15_uc010aqk.2_RNA	NM_198686	NP_941959	P59190	RAB15_HUMAN	RAB15, member RAS onocogene family	Error:Variant_position_missing_in_P59190_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)	1				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)		CTCCACACCCCGGCAGTGAGG	0.562			NA											3	54					0	0	0.004672	0	0
FUT8	2530	broad.mit.edu	37	14	66135974	66135974	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:66135974G>C	uc001xin.2	+	7	1808	c.611G>C	c.(610-612)TGC>TCC	p.C204S	FUT8_uc001xio.2_Missense_Mutation_p.C204S|FUT8_uc010tsp.1_Missense_Mutation_p.C41S|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.C204S|FUT8_uc001xiq.2_Missense_Mutation_p.C75S|FUT8_uc001xis.2_5'Flank	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	204	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CCCAAGGACTGCAGCAAAGCC	0.383			NA											24	81					0	0	0.00632	0	0
FAM71D	161142	broad.mit.edu	37	14	67675062	67675062	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:67675062C>T	uc001xja.1	+	6	1310	c.1056C>T	c.(1054-1056)ACC>ACT	p.T352T	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	352										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CTACCTTGACCCCAGTAGAAA	0.383			NA											36	174					0	0	0.006999	0	0
SMOC1	64093	broad.mit.edu	37	14	70490078	70490078	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:70490078G>T	uc001xls.1	+	11	1458	c.1205G>T	c.(1204-1206)CGG>CTG	p.R402L	SMOC1_uc001xlt.1_Missense_Mutation_p.R402L	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	402	EF-hand 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AAATGTGCCCGGCGTTTCACC	0.527			NA											95	328					1.14165e-66	2.11127e-66	0.00361	1	0
ADAM21P1	145241	broad.mit.edu	37	14	70714185	70714185	+	Translation_Start_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:70714185G>T	uc010ttg.1	-	1	334	c.-317C>A	c.(-319--315)GTCTG>GTATG			NR_003951				SubName: Full=ADAM21-like protein;												0						CCAAACCGCAGACTATAGGAG	0.522			NA											4	43					0.00116845	0.00123961	0.001168	1	0
ADAM20	8748	broad.mit.edu	37	14	70991190	70991190	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:70991190C>A	uc001xme.2	-	2	680	c.435G>T	c.(433-435)CAG>CAT	p.Q145H		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	95					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GCAGGGCATGCTGCTCTGTGT	0.522			NA											84	461					5.70515e-31	9.07446e-31	0.00361	1	0
DIO2	1734	broad.mit.edu	37	14	80669342	80669342	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:80669342G>T	uc010tvq.1	-	4	914	c.512C>A	c.(511-513)GCG>GAG	p.A171E	DIO2_uc010tvp.1_Missense_Mutation_p.A207E|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Missense_Mutation_p.A171E|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	171					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCCCGGTATCGCCCAGCCATC	0.552			NA									OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	128					3.73988e-18	5.25921e-18	0.00632	1	0
GALC	2581	broad.mit.edu	37	14	88407816	88407816	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:88407816C>A	uc001xvt.2	-	15	2156	c.1757G>T	c.(1756-1758)GGT>GTT	p.G586V	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Missense_Mutation_p.G560V|GALC_uc010tvy.1_Missense_Mutation_p.G563V|GALC_uc010tvz.1_Missense_Mutation_p.G530V	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	586					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						AATCAAAATACCACCTTTATT	0.358			NA											40	442					1.23713e-20	1.78623e-20	0.00361	1	0
SMEK1	55671	broad.mit.edu	37	14	91927780	91927780	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:91927780C>A	uc001xzn.2	-	14	3158	c.2336G>T	c.(2335-2337)GGC>GTC	p.G779V	SMEK1_uc001xzm.2_Missense_Mutation_p.G766V|SMEK1_uc001xzo.2_Missense_Mutation_p.G766V|SMEK1_uc010atz.2_Missense_Mutation_p.G540V	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	779						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		TCCAGGAGAGCCTGGAGATCC	0.488			NA											50	351					2.41709e-19	3.43481e-19	0.00361	1	0
PPP4R4	57718	broad.mit.edu	37	14	94731788	94731788	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:94731788C>T	uc001ycs.1	+	21	2416	c.2262C>T	c.(2260-2262)CCC>CCT	p.P754P		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	754						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TTCCTGGACCCTCTTCTGTCA	0.358			NA											19	161					0	0	0.00278	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914953	94914953	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:94914953G>T	uc001ydd.1	-	2	219	c.159C>A	c.(157-159)ACC>ACA	p.T53T		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	53					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		AATTGGTAATGGTGGGTGTGA	0.572			NA											135	509					1.12709e-80	2.12436e-80	0.00361	1	0
SERPINA9	327657	broad.mit.edu	37	14	94936027	94936027	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:94936027A>T	uc001ydf.2	-	2	366	c.205T>A	c.(205-207)TTT>ATT	p.F69I	SERPINA9_uc001yde.2_Missense_Mutation_p.F69I|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.F69I|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	51					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CGGAAGGCAAAGTCGGTGTTG	0.582			NA											144	385					0	0	0.00361	0	0
SERPINA9	327657	broad.mit.edu	37	14	94936140	94936140	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:94936140C>G	uc001ydf.2	-	2	253	c.92G>C	c.(91-93)GGC>GCC	p.G31A	SERPINA9_uc001yde.2_Missense_Mutation_p.G31A|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.G31A|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	13					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AGCACAGAGGCCAACAGCAAA	0.517			NA											183	630					0	0	0.00361	0	0
DICER1	23405	broad.mit.edu	37	14	95573945	95573945	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:95573945C>T	uc001ydw.2	-	18	2986	c.2804G>A	c.(2803-2805)AGA>AAA	p.R935K	DICER1_uc010avh.1_5'Flank|DICER1_uc001ydv.2_Missense_Mutation_p.R925K|DICER1_uc001ydx.2_Missense_Mutation_p.R935K	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	935	PAZ.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AAATACCTACCTTGGAATGAT	0.274			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				6	153					0	0	0.001984	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476788	102476788	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:102476788G>T	uc001yks.2	+	31	6561	c.6397G>T	c.(6397-6399)GAA>TAA	p.E2133*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2133					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAATCTCCCTGAACAAGAGGT	0.388			NA											28	50					9.17885e-22	1.34873e-21	0.003271	1	0
AHNAK2	113146	broad.mit.edu	37	14	105407714	105407714	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:105407714C>T	uc010axc.1	-	7	14194	c.14074G>A	c.(14074-14076)GAA>AAA	p.E4692K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E4592K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4692						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATTCCAACTTCTCCAACAGCA	0.413			NA											4	16					0	0	0.000602	0	0
GPR132	29933	broad.mit.edu	37	14	105518393	105518393	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:105518393G>T	uc001yqd.2	-	4	980	c.81C>A	c.(79-81)GGC>GGA	p.G27G	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Silent_p.G18G	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	27	Extracellular (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		TGGCGGAGAGGCCCAGGGAGG	0.637			NA											11	22					3.27435e-08	3.83963e-08	0.00245	1	0
BUB1B	701	broad.mit.edu	37	15	40468681	40468681	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:40468681C>T	uc001zkx.3	+	5	600	c.388C>T	c.(388-390)CGT>TGT	p.R130C	BUB1B_uc010ucl.1_5'UTR	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	130	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GTTACAGGGGCGTTTATGCAA	0.398			NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				77	169					0	0	0.00361	0	0
TGM7	116179	broad.mit.edu	37	15	43585794	43585794	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:43585794T>A	uc001zrf.1	-	2	51	c.46A>T	c.(46-48)AGC>TGC	p.S16C		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	16					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TTCCTGGAGCTCTGCAGGTCG	0.652			NA											3	12					0	0	0.004672	0	0
CKMT1B	1159	broad.mit.edu	37	15	43890471	43890471	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:43890471C>T	uc001zsc.2	+	8	1349	c.957C>T	c.(955-957)AAC>AAT	p.N319N	CKMT1B_uc010uds.1_Silent_p.N350N|CKMT1B_uc010udv.1_3'UTR|CKMT1B_uc001zsd.3_Silent_p.N319N|CKMT1B_uc010bdj.2_RNA|CKMT1B_uc010udy.1_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	319	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	GTCCATCTAACCTGGGCACTG	0.512			NA											50	179					0	0	0.00361	0	0
DUOX1	53905	broad.mit.edu	37	15	45444142	45444142	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:45444142C>A	uc001zus.1	+	25	3431	c.3085C>A	c.(3085-3087)CAG>AAG	p.Q1029K	DUOX1_uc001zut.1_Missense_Mutation_p.Q1029K|DUOX1_uc010bee.1_Missense_Mutation_p.Q409K|DUOX1_uc001zuu.2_Missense_Mutation_p.Q171K	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1029	Cytoplasmic (Potential).|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTGTCTCCACCAGACGGTGCA	0.587			NA											15	51					1.15088e-07	1.33507e-07	0.004007	1	0
SLC12A1	6557	broad.mit.edu	37	15	48500307	48500307	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:48500307C>A	uc001zwn.3	+	2	607	c.391C>A	c.(391-393)CTG>ATG	p.L131M	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Missense_Mutation_p.L131M|SLC12A1_uc010uex.1_Missense_Mutation_p.L131M	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	131	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CCGACCCAGCCTGCTTGAGAT	0.468			NA											115	168					1.24568e-56	2.22369e-56	0.00361	1	0
SLC27A2	11001	broad.mit.edu	37	15	50494839	50494839	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:50494839G>T	uc001zxw.2	+	3	1076	c.844G>T	c.(844-846)GCT>TCT	p.A282S	SLC27A2_uc010bes.2_Intron|SLC27A2_uc001zxx.2_Missense_Mutation_p.A47S	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	282	Helical; (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		ATGTATTGTGGCTGGTAAGCT	0.428			NA											22	439					5.61819e-17	7.75913e-17	0.005443	1	0
UNC13C	440279	broad.mit.edu	37	15	54307745	54307745	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:54307745T>A	uc002ack.2	+	1	2645	c.2645T>A	c.(2644-2646)ATG>AAG	p.M882K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	882					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTTGAAGTCATGGAACAAGTC	0.378			NA											96	198					0	0	0.00361	0	0
NEDD4	4734	broad.mit.edu	37	15	56140724	56140724	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:56140724T>C	uc002adj.2	-	12	3035	c.2735A>G	c.(2734-2736)AAT>AGT	p.N912S	NEDD4_uc002adl.2_Missense_Mutation_p.N493S|NEDD4_uc002adi.2_Missense_Mutation_p.N840S|NEDD4_uc010ugj.1_Missense_Mutation_p.N896S|NEDD4_uc010bfm.2_Missense_Mutation_p.N895S|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	912	WW 4.|Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CATACTGTGATTTATGTAGAA	0.308			NA											21	63					0	0	0.00632	0	0
BNIP2	663	broad.mit.edu	37	15	59961504	59961504	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:59961504T>A	uc010uhc.1	-	8	1131	c.1128A>T	c.(1126-1128)ACA>ACT	p.T376T	BNIP2_uc002agi.3_5'Flank|BNIP2_uc010uhb.1_Silent_p.T317T	NM_004330	NP_004321	Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 2	255	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1						CAGCCAGAAGTGTTCTGATAA	0.244	Ovarian(174;1936 1978 6671 8240 38212)		NA											16	51					0	0	0.00278	0	0
VPS13C	54832	broad.mit.edu	37	15	62264919	62264919	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:62264919T>C	uc002agz.2	-	27	2736	c.2662A>G	c.(2662-2664)ACT>GCT	p.T888A	VPS13C_uc002aha.2_Missense_Mutation_p.T845A|VPS13C_uc002ahb.1_Missense_Mutation_p.T888A|VPS13C_uc002ahc.1_Missense_Mutation_p.T845A	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	888					protein localization					ovary(2)	2						CTTTTACAAGTCTGTGGTTCT	0.348			NA											48	164					0	0	0.00361	0	0
C15orf60	283677	broad.mit.edu	37	15	73852136	73852136	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:73852136C>A	uc002avq.2	+	6	708	c.680C>A	c.(679-681)TCT>TAT	p.S227Y	C15orf60_uc010bjb.2_Missense_Mutation_p.S199Y	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	227										pancreas(1)	1						TATGAACAATCTGCATGGGGT	0.463			NA											38	101					5.75399e-11	7.15111e-11	0.00361	1	0
ISLR	3671	broad.mit.edu	37	15	74467708	74467708	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:74467708C>T	uc002axg.1	+	2	791	c.509C>T	c.(508-510)ACC>ATC	p.T170I	ISLR_uc002axh.1_Missense_Mutation_p.T170I	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	170					cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						ACCCCGCTCACCGCGCTGTCC	0.657			NA											15	29					0	0	0.008871	0	0
MAN2C1	4123	broad.mit.edu	37	15	75650895	75650895	+	Missense_Mutation	SNP	C	C	T	rs150018240		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:75650895C>T	uc002baf.2	-	20	2328	c.2311G>A	c.(2311-2313)GCC>ACC	p.A771T	MAN2C1_uc002bag.2_Missense_Mutation_p.A771T|MAN2C1_uc002bah.2_Missense_Mutation_p.A788T|MAN2C1_uc010bkk.2_Missense_Mutation_p.A672T	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	771					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						AAGAACCAGGCGCTGCCCCGC	0.647			NA											8	14					0	0	0.006214	0	0
CPEB1	64506	broad.mit.edu	37	15	83215961	83215961	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:83215961G>A	uc002bit.2	-	10	1758	c.1621C>T	c.(1621-1623)CAA>TAA	p.Q541*	CPEB1_uc002biq.2_Nonsense_Mutation_p.Q401*|CPEB1_uc002bir.2_Nonsense_Mutation_p.Q406*|CPEB1_uc002bis.2_Nonsense_Mutation_p.Q401*|CPEB1_uc010uod.1_Nonsense_Mutation_p.Q250*|CPEB1_uc010uoe.1_Nonsense_Mutation_p.Q479*|CPEB1_uc002biu.2_Nonsense_Mutation_p.Q503*|CPEB1_uc010uof.1_Nonsense_Mutation_p.Q401*|CPEB1_uc002biv.2_Nonsense_Mutation_p.Q476*|CPEB1_uc002bip.2_Nonsense_Mutation_p.Q250*	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	481	RRM 2.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TAACTCCGTTGGTTATTGAAA	0.413			NA											25	92					0	0	0.007291	0	0
SH3GL3	6457	broad.mit.edu	37	15	84237364	84237364	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:84237364G>A	uc002bjw.2	+	4	466	c.271G>A	c.(271-273)GGC>AGC	p.G91S	SH3GL3_uc010uot.1_Missense_Mutation_p.G91S|SH3GL3_uc002bjx.2_Missense_Mutation_p.G22S|SH3GL3_uc002bju.2_Missense_Mutation_p.G99S|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	91	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GCAGACGGAAGGCTTGCTGGG	0.517			NA											14	171					0	0	0.00499	0	0
SH3GL3	6457	broad.mit.edu	37	15	84237394	84237394	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:84237394G>T	uc002bjw.2	+	4	496	c.301G>T	c.(301-303)GGG>TGG	p.G101W	SH3GL3_uc010uot.1_Missense_Mutation_p.G101W|SH3GL3_uc002bjx.2_Missense_Mutation_p.G32W|SH3GL3_uc002bju.2_Missense_Mutation_p.G109W|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	101	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GCTGAAATACGGGAAGGAGCT	0.527			NA											41	103					3.39706e-21	4.92459e-21	0.00361	1	0
ZNF592	9640	broad.mit.edu	37	15	85326477	85326477	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:85326477G>C	uc002bld.2	+	4	907	c.571G>C	c.(571-573)GTT>CTT	p.V191L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	191					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TAAGTTTCCGGTTCCAGAGCT	0.537			NA											29	89					0	0	0.008361	0	0
AGBL1	123624	broad.mit.edu	37	15	86838537	86838537	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:86838537C>A	uc002blz.1	+	16	2214	c.2134C>A	c.(2134-2136)CGG>AGG	p.R712R	AGBL1_uc002bma.1_Silent_p.R443R|AGBL1_uc002bmb.1_Silent_p.R406R	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	712					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GGTCTACTTCCGGCAAGATGT	0.468			NA											81	156					5.2429e-30	8.26618e-30	0.00361	1	0
TARSL2	123283	broad.mit.edu	37	15	102197168	102197168	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:102197168C>T	uc002bxm.2	-	18	2272	c.2217G>A	c.(2215-2217)AAG>AAA	p.K739K	TARSL2_uc002bxl.2_3'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	739					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCGTATTTTCTTATTTAGTG	0.313			NA											10	24					0	0	0.001855	0	0
SRRM2	23524	broad.mit.edu	37	16	2814828	2814828	+	Silent	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:2814828A>G	uc002crk.2	+	11	4848	c.4299A>G	c.(4297-4299)AGA>AGG	p.R1433R	SRRM2_uc002crj.1_Silent_p.R1337R|SRRM2_uc002crl.1_Silent_p.R1433R|SRRM2_uc010bsu.1_Silent_p.R1337R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1433	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTTTACCCAGAACTCCATCAA	0.512			NA											5	286					0	0	0.000602	0	0
GPR139	124274	broad.mit.edu	37	16	20043655	20043655	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20043655G>T	uc002dgu.1	-	2	626	c.464C>A	c.(463-465)ACC>AAC	p.T155N	GPR139_uc010vaw.1_Missense_Mutation_p.T62N	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	155	Helical; Name=4; (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CAGGAAGCAGGTGATGTAAAC	0.522			NA											35	316					7.53189e-24	1.1251e-23	0.007835	1	0
UMOD	7369	broad.mit.edu	37	16	20360484	20360484	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20360484C>A	uc002dgz.2	-	3	268	c.139G>T	c.(139-141)GTT>TTT	p.V47F	UMOD_uc002dha.2_Missense_Mutation_p.V47F|UMOD_uc002dhb.2_Missense_Mutation_p.V80F	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	47	EGF-like 1.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CACGTCGTAACGGCCTCATCC	0.612			NA											3	47					0.004672	0.00487985	0.004672	1	0
PDILT	204474	broad.mit.edu	37	16	20380897	20380897	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20380897C>A	uc002dhc.1	-	8	1256	c.1033G>T	c.(1033-1035)GCC>TCC	p.A345S		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	345					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TTGTACCTGGCGTCAGAGCTC	0.468			NA											48	330					4.88482e-21	7.0624e-21	0.00361	1	0
OTOA	146183	broad.mit.edu	37	16	21737980	21737980	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:21737980G>T	uc002djh.2	+	18	2017	c.2016_splice	c.e18+1	p.L672_splice	uc002diq.3_Intron|OTOA_uc010vbj.1_Splice_Site_p.L593_splice|OTOA_uc002dji.2_Splice_Site_p.L348_splice|OTOA_uc010vbk.1_Splice_Site_p.L320_splice	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1						sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		GCAGTGCCTGGTAAGAAAACT	0.537			NA											31	190					2.87052e-16	3.90941e-16	0.005524	1	0
PDZD9	255762	broad.mit.edu	37	16	21999929	21999929	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:21999929A>C	uc002dka.1	-	4	526	c.209T>G	c.(208-210)GTA>GGA	p.V70G		NM_173806	NP_776167	Q8IXQ8	PDZD9_HUMAN	hypothetical protein LOC255762	132										pancreas(1)	1						TTACCTTGTTACTGGGAATTT	0.343			NA											29	82					0	0	0.009535	0	0
PALB2	79728	broad.mit.edu	37	16	23634330	23634330	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:23634330C>A	uc002dlx.1	-	9	3156	c.2956G>T	c.(2956-2958)GAT>TAT	p.D986Y		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	986	Interaction with RAD51 and BRCA2.|WD 3.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		ACTTGTTGATCAGAAAGGGTC	0.378			NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				46	196					1.44317e-28	2.25234e-28	0.00361	1	0
DCTN5	84516	broad.mit.edu	37	16	23669846	23669846	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:23669846T>G	uc002dly.1	+	3	193	c.136T>G	c.(136-138)TGT>GGT	p.C46G		NM_032486	NP_115875	Q9BTE1	DCTN5_HUMAN	dynactin 5	46						centrosome	transferase activity			upper_aerodigestive_tract(1)	1				GBM - Glioblastoma multiforme(48;0.0156)		GATGAATGACTGTATTATCCG	0.378			NA											6	249					0	0	0.001168	0	0
ERN2	10595	broad.mit.edu	37	16	23713521	23713521	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:23713521T>C	uc002dma.3	-	11	1468	c.1299A>G	c.(1297-1299)GCA>GCG	p.A433A	ERN2_uc010bxp.2_Silent_p.A433A|ERN2_uc010bxq.1_Silent_p.A241A	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	385	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GTCTTGTCTCTGCAGTTCCAC	0.622			NA											8	70					0	0	0.00308	0	0
PRKCB	5579	broad.mit.edu	37	16	24046867	24046867	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:24046867C>A	uc002dmd.2	+	5	725	c.528C>A	c.(526-528)CTC>CTA	p.L176L	PRKCB_uc002dme.2_Silent_p.L176L	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	176	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TCATTGTCCTCGGTAGGTGGC	0.647			NA											29	129					9.65021e-13	1.24222e-12	0.002096	1	0
RBBP6	5930	broad.mit.edu	37	16	24578506	24578506	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:24578506G>C	uc002dmh.2	+	15	2672	c.1632G>C	c.(1630-1632)AGG>AGC	p.R544S	RBBP6_uc010vcb.1_Missense_Mutation_p.R411S|RBBP6_uc002dmi.2_Missense_Mutation_p.R544S|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.R411S	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	544					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GATCACAGAGGACTCAAGGCC	0.294			NA											41	144					0	0	0.00361	0	0
SLC5A11	115584	broad.mit.edu	37	16	24895432	24895432	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:24895432C>T	uc002dmu.2	+	8	876	c.644C>T	c.(643-645)GCG>GTG	p.A215V	SLC5A11_uc002dms.2_Missense_Mutation_p.A151V|SLC5A11_uc010vcd.1_Missense_Mutation_p.A180V|SLC5A11_uc002dmt.2_Missense_Mutation_p.A151V|SLC5A11_uc010vce.1_Missense_Mutation_p.A145V|SLC5A11_uc010bxt.2_Missense_Mutation_p.A151V	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	215	Helical; (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		CTTATAGGAGCGCTCACCTTG	0.592			NA											91	313					0	0	0.00361	0	0
GTF3C1	2975	broad.mit.edu	37	16	27540011	27540011	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:27540011T>A	uc002dov.1	-	6	921	c.881A>T	c.(880-882)TAC>TTC	p.Y294F	GTF3C1_uc002dou.2_Missense_Mutation_p.Y294F	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	294						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CATATACTGGTACAGACGCTT	0.453			NA											21	562					0	0	0.003954	0	0
APOB48R	55911	broad.mit.edu	37	16	28509228	28509228	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:28509228G>T	uc002dqb.1	+	3	2849	c.2839G>T	c.(2839-2841)GCA>TCA	p.A947S	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.A485S	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	947	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						CCAGGCCCCTGCAGAAGCTGC	0.667			NA											24	82					7.26314e-15	9.58948e-15	0.007291	1	0
ATP2A1	487	broad.mit.edu	37	16	28898990	28898990	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:28898990C>T	uc002dro.1	+	8	1059	c.875C>T	c.(874-876)GCC>GTC	p.A292V	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.A292V|ATP2A1_uc002drp.1_Missense_Mutation_p.A167V|ATP2A1_uc010bym.1_5'Flank	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	292	Lumenal (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCCGCGGGGCCATCTACTAC	0.547			NA											3	48					0	0	0.004672	0	0
SPN	6693	broad.mit.edu	37	16	29675148	29675148	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:29675148G>T	uc002dtm.2	+	2	235	c.99G>T	c.(97-99)TTG>TTT	p.L33F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.L33F|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	33	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						GAGAGCCTTTGGTCTCTACTA	0.577			NA											17	81					1.2644e-06	1.44656e-06	0.010504	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29897071	29897071	+	Splice_Site	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:29897071C>T	uc002duq.3	-	8	1449	c.1209_splice	c.e8-1	p.R403_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Splice_Site_p.R333_splice|SEZ6L2_uc002dur.3_Splice_Site_p.R333_splice|SEZ6L2_uc002dus.3_Splice_Site_p.R289_splice|SEZ6L2_uc010vec.1_Splice_Site_p.R403_splice|SEZ6L2_uc010ved.1_Splice_Site_p.R359_splice	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CACCATCAGCCTGGGATGGAC	0.557			NA											3	40					0	0	0.000602	0	0
ARMC5	79798	broad.mit.edu	37	16	31471201	31471201	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:31471201C>T	uc002ecc.2	+	1	885	c.356C>T	c.(355-357)CCT>CTT	p.P119L	ARMC5_uc010vfn.1_Missense_Mutation_p.P214L|ARMC5_uc010vfo.1_Missense_Mutation_p.P151L|ARMC5_uc002eca.3_Missense_Mutation_p.P119L|ARMC5_uc010vfp.1_Missense_Mutation_p.P119L|ARMC5_uc002ecb.2_Missense_Mutation_p.P119L	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	119							binding			pancreas(1)	1						TCGTCTAGTCCTACGCCGCCA	0.587			NA											7	20					0	0	0.00308	0	0
VPS35	55737	broad.mit.edu	37	16	46715307	46715307	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:46715307C>G	uc002eef.3	-	4	404	c.305G>C	c.(304-306)GGA>GCA	p.G102A	VPS35_uc002eed.2_5'Flank|VPS35_uc002eee.2_Missense_Mutation_p.G63A	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	102					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GATAATGTTTCCAGCATACTG	0.378			NA											31	140					0	0	0.004878	0	0
CNOT1	23019	broad.mit.edu	37	16	58616700	58616700	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:58616700T>A	uc002env.2	-	10	1334	c.1041A>T	c.(1039-1041)GAA>GAT	p.E347D	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.E347D|CNOT1_uc002enx.2_Missense_Mutation_p.E347D|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	347					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TACTCACCAGTTCTTTAAGAA	0.383			NA											5	34					0	0	0.000602	0	0
CDH1	999	broad.mit.edu	37	16	68849475	68849475	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:68849475G>T	uc002ewg.1	+	10	1502	c.1378G>T	c.(1378-1380)GTA>TTA	p.V460L	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.V399L	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	460	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.G441_E463del(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GACGAATGTGGTACCTTTTGA	0.473			NA	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				47	259					4.44712e-29	6.96071e-29	0.00361	1	0
NFAT5	10725	broad.mit.edu	37	16	69660388	69660388	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:69660388C>T	uc002exm.1	+	2	1364	c.156C>T	c.(154-156)AGC>AGT	p.S52S	NFAT5_uc002exh.1_5'UTR|NFAT5_uc002exi.2_5'UTR|NFAT5_uc002exj.1_5'UTR|NFAT5_uc002exk.1_5'UTR|NFAT5_uc002exl.1_Silent_p.S70S|NFAT5_uc002exn.1_Silent_p.S70S	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	52					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCAGACAAGCGGTGGTGAGG	0.448			NA											4	67					0	0	0.001984	0	0
HYDIN	54768	broad.mit.edu	37	16	70897063	70897063	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:70897063G>T	uc002ezr.2	-	68	11619	c.11491C>A	c.(11491-11493)CGT>AGT	p.R3831S	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3832										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGCTGGACACGTCCTGAATTA	0.463			NA											31	195					2.05212e-20	2.94719e-20	0.005524	1	0
HYDIN	54768	broad.mit.edu	37	16	70908208	70908208	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:70908208C>A	uc002ezr.2	-	64	11073	c.10945G>T	c.(10945-10947)GCT>TCT	p.A3649S		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3650										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TTTCTCCCACCTGCCACCAAG	0.458			NA											36	242					2.56175e-15	3.41145e-15	0.00361	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76486483	76486484	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:76486483_76486484CC>AG	uc002feu.1	+	10	1535_1536	c.1150_1151CC>AG	c.(1150-1152)CCA>AGA	p.P384R	CNTNAP4_uc002fev.1_Missense_Mutation_p.P248R|CNTNAP4_uc010chb.1_Missense_Mutation_p.P311R|CNTNAP4_uc002fex.1_Missense_Mutation_p.P387R|CNTNAP4_uc002few.2_Missense_Mutation_p.P359R	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	384	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TTTAGCACTGCCAGACTTCTCT	0.431			NA											15	124					0	0	0.004672	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84906614	84906614	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:84906614G>C	uc010voh.1	+	10	1225	c.998G>C	c.(997-999)CGC>CCC	p.R333P	CRISPLD2_uc010vog.1_Intron|CRISPLD2_uc002fio.2_Missense_Mutation_p.R332P|CRISPLD2_uc002fim.2_Missense_Mutation_p.R333P|CRISPLD2_uc002fin.3_Missense_Mutation_p.R333P	NM_031476	NP_113664	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain	333	LCCL 1.					extracellular region|transport vesicle					0						AGCATATGCCGCGCCGCCATC	0.547			NA											25	148					0	0	0.002096	0	0
FAM92B	339145	broad.mit.edu	37	16	85139044	85139044	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:85139044C>A	uc010vok.1	-	5	583	c.427_splice	c.e5-1	p.S143_splice		NM_198491	NP_940893	Q6ZTR7	FA92B_HUMAN	hypothetical protein LOC339145											central_nervous_system(1)	1						CTGCCTGGCCCCAGGGACACA	0.582			NA											10	16					2.17888e-05	2.42847e-05	0.006214	1	0
OR3A3	8392	broad.mit.edu	37	17	3324705	3324705	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:3324705G>T	uc010vrd.1	+	1	844	c.844G>T	c.(844-846)GGG>TGG	p.G282W		NM_012373	NP_036505	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAGGATAAGGGGGTTGGGGT	0.507			NA											114	252					6.85551e-66	1.26563e-65	0.00361	1	0
USP6	9098	broad.mit.edu	37	17	5045714	5045714	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:5045714G>A	uc002gau.1	+	25	3965	c.1735G>A	c.(1735-1737)GGG>AGG	p.G579R	USP6_uc002gav.1_Missense_Mutation_p.G579R|USP6_uc010ckz.1_Missense_Mutation_p.G262R	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	579					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						TGGTATGAAGGGGCATATGGC	0.418			NA	T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								7	17					0	0	0.001855	0	0
MYH1	4619	broad.mit.edu	37	17	10399714	10399714	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:10399714G>T	uc002gmo.2	-	34	4903	c.4809C>A	c.(4807-4809)AGC>AGA	p.S1603R	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1603	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CATCCAGTGTGCTCTGCATGG	0.448			NA											199	477					1.23147e-137	2.37922e-137	0.00361	1	0
MYH2	4620	broad.mit.edu	37	17	10448802	10448802	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:10448802G>A	uc010coi.2	-	5	494	c.366C>T	c.(364-366)TTC>TTT	p.F122F	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.F122F|MYH2_uc010coj.2_Silent_p.F122F	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	122	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CAGTGACACAGAAGAGACCTG	0.443			NA											23	65					0	0	0.003954	0	0
DNAH9	1770	broad.mit.edu	37	17	11622751	11622751	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:11622751C>T	uc002gne.2	+	27	5721	c.5653C>T	c.(5653-5655)CGC>TGC	p.R1885C	DNAH9_uc010coo.2_Missense_Mutation_p.R1179C	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1885	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGACCTGGGCCGCGCACTGGG	0.627			NA											4	104					0	0	0.000602	0	0
DNAH9	1770	broad.mit.edu	37	17	11726350	11726350	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:11726350A>T	uc002gne.2	+	48	9313	c.9245A>T	c.(9244-9246)CAG>CTG	p.Q3082L	DNAH9_uc010coo.2_Missense_Mutation_p.Q2376L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3082	Stalk (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACCTCTGCCCAGGTGAGCAAT	0.542			NA											14	38					0	0	0.003163	0	0
LGALS9	3965	broad.mit.edu	37	17	25967657	25967657	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:25967657C>T	uc002gzp.2	+	3	309	c.191C>T	c.(190-192)CCT>CTT	p.P64L	LGALS9_uc002gzq.2_Missense_Mutation_p.P64L|LGALS9_uc002gzr.2_Intron|LGALS9_uc010waa.1_Intron|LGALS9_uc002gzs.2_Missense_Mutation_p.P64L	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	64	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		CACTTCAACCCTCGGTTTGAA	0.527	Melanoma(106;677 1527 28724 29571 46552)|Ovarian(193;263 2088 2118 29005 43023)		NA											17	55					0	0	0.008871	0	0
MYO1D	4642	broad.mit.edu	37	17	31105502	31105502	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:31105502C>A	uc002hho.1	-	3	406	c.394G>T	c.(394-396)GAA>TAA	p.E132*	MYO1D_uc002hhp.1_Nonsense_Mutation_p.E132*|MYO1D_uc010wcb.1_Nonsense_Mutation_p.E132*	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	132	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TCTTACCTTTCAACCTCTGCT	0.478			NA											44	111					3.28156e-27	5.04855e-27	0.00361	1	0
AATF	26574	broad.mit.edu	37	17	35311178	35311178	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:35311178G>A	uc002hni.2	+	4	1054	c.803G>A	c.(802-804)GGC>GAC	p.G268D	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	268					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				GACAAAGGTGGCCCAGAATTT	0.418	NSCLC(49;901 1159 19183 41572 46244)		NA											11	119					0	0	0.001855	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36935738	36935738	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:36935738C>T	uc002hqs.2	-	5	1033	c.552G>A	c.(550-552)CTG>CTA	p.L184L	PIP4K2B_uc010wdt.1_Silent_p.L184L|PIP4K2B_uc010wdu.1_Silent_p.L120L	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	184	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						GGTACATGCCCAGGAACTGTG	0.517			NA											53	573					0	0	0.00361	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582			1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			105	145					0	0	0.00361	0	0
NKIRAS2	28511	broad.mit.edu	37	17	40175884	40175884	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:40175884C>T	uc002hyq.2	+	4	614	c.549C>T	c.(547-549)AAC>AAT	p.N183N	NKIRAS2_uc010wgd.1_3'UTR|NKIRAS2_uc002hyr.2_Silent_p.N183N|NKIRAS2_uc002hys.2_Silent_p.N183N|NKIRAS2_uc010wge.1_Silent_p.N127N|NKIRAS2_uc002hyt.2_Silent_p.N183N	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	183	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				GCCGGAAGAACAAGGGCAGCG	0.607			NA											12	27					0	0	0.004007	0	0
WNK4	65266	broad.mit.edu	37	17	40940775	40940775	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:40940775A>C	uc002ibj.2	+	11	2138	c.2117A>C	c.(2116-2118)GAT>GCT	p.D706A	WNK4_uc010wgx.1_Missense_Mutation_p.D370A|WNK4_uc002ibk.1_Missense_Mutation_p.D478A|WNK4_uc010wgy.1_Missense_Mutation_p.D50A	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	706					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTCCGATTTGATCTGGATGGG	0.517	Esophageal Squamous(6;201 374 4964 23855 42828)		NA											7	89					0	0	0.004482	0	0
ITGA2B	3674	broad.mit.edu	37	17	42455747	42455747	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:42455747C>A	uc002igt.1	-	20	2109	c.2077G>T	c.(2077-2079)GCC>TCC	p.A693S	ITGA2B_uc002igu.1_Missense_Mutation_p.A174S	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	693	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TTGCTTAGGGCCCGCATGTAG	0.647			NA											14	2					3.52763e-06	3.99774e-06	0.00499	1	0
STXBP4	252983	broad.mit.edu	37	17	53068212	53068212	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:53068212T>C	uc002iuf.1	+	4	281	c.74T>C	c.(73-75)ATT>ACT	p.I25T	STXBP4_uc010dcc.1_Intron|STXBP4_uc010dcd.1_Missense_Mutation_p.I25T	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	25	PDZ.					cytoplasm	calcium ion binding			ovary(1)	1						ATGATTACAATTGCCAAGGAA	0.393			NA											17	313					0	0	0.010504	0	0
EPX	8288	broad.mit.edu	37	17	56270730	56270730	+	Splice_Site	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:56270730A>T	uc002ivq.2	+	3	257	c.171_splice	c.e3-2	p.S57_splice		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein						hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TCTCCTGGGCAGCATCAAGCA	0.637			NA											44	251					0	0	0.00361	0	0
PPM1E	22843	broad.mit.edu	37	17	57043137	57043137	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:57043137C>A	uc002iwx.2	+	3	793	c.666C>A	c.(664-666)CTC>CTA	p.L222L	PPM1E_uc010ddd.2_Intron	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	231			L -> S (in a breast cancer sample; somatic mutation).		protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			ACTTCCCCCTCCGCAGGAGAC	0.453			NA											7	287					0.00448238	0.00470454	0.004482	1	0
BRIP1	83990	broad.mit.edu	37	17	59760806	59760806	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:59760806T>C	uc002izk.1	-	20	3742	c.3601A>G	c.(3601-3603)ATT>GTT	p.I1201V		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1201					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CTTTCTTCAATATGCAGAATT	0.303			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				50	83					0	0	0.00361	0	0
INTS2	57508	broad.mit.edu	37	17	59962347	59962347	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:59962347G>A	uc002izn.2	-	16	2104	c.2028C>T	c.(2026-2028)CCC>CCT	p.P676P	INTS2_uc002izm.2_Silent_p.P668P	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	676					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						AATATGATTTGGGCTTTCTTT	0.353			NA											12	39					0	0	0.00245	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351433	60351433	+	Missense_Mutation	SNP	C	C	A	rs148852498	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:60351433C>A	uc002izq.2	-	2	156	c.44G>T	c.(43-45)CGA>CTA	p.R15L	TBC1D3P2_uc010woz.1_RNA					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						GATGTCCTCTCGCTCTTGTGC	0.527			NA											10	247					7.93312e-07	9.0953e-07	0.00245	1	0
SCN4A	6329	broad.mit.edu	37	17	62018710	62018710	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:62018710C>G	uc002jds.1	-	24	5009	c.4932G>C	c.(4930-4932)GTG>GTC	p.V1644V		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1644					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCAGGGTGTCCACGAAGTCTG	0.567			NA											15	47					0	0	0.00499	0	0
TEX2	55852	broad.mit.edu	37	17	62272302	62272302	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:62272302C>A	uc002jec.2	-	3	1971	c.1798G>T	c.(1798-1800)GAG>TAG	p.E600*	TEX2_uc002jed.2_Nonsense_Mutation_p.E600*|TEX2_uc002jee.2_Nonsense_Mutation_p.E600*	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	600					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TAGGTGACCTCTGGCTTGGGT	0.443			NA											42	114					1.56989e-16	2.15163e-16	0.00361	1	0
PITPNC1	26207	broad.mit.edu	37	17	65688809	65688809	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:65688809C>A	uc002jgc.2	+	9	1151	c.804C>A	c.(802-804)GTC>GTA	p.V268V	PITPNC1_uc002jgb.2_3'UTR	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	268					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			CTTCTTCCGTCCGCAGTGCGC	0.552			NA											8	266					0.000274275	0.000298005	0.004482	1	0
ABCA9	10350	broad.mit.edu	37	17	67039769	67039769	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:67039769C>A	uc002jhu.2	-	6	804	c.661G>T	c.(661-663)GTT>TTT	p.V221F	ABCA9_uc010dez.2_Missense_Mutation_p.V221F|ABCA9_uc002jhv.2_Missense_Mutation_p.V221F	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	221	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCAGTTGCAACTCCTCCTTGG	0.328			NA											31	227					2.1956e-27	3.38749e-27	0.004289	1	0
ABCA10	10349	broad.mit.edu	37	17	67151277	67151277	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:67151277C>A	uc010dfa.1	-	31	4456	c.3577G>T	c.(3577-3579)GAA>TAA	p.E1193*	ABCA10_uc010wqs.1_Nonsense_Mutation_p.E185*|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1193					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					ATGACTGGTTCCTGGAAAACA	0.323			NA											32	74					1.61004e-24	2.42855e-24	0.00361	1	0
TNRC6C	57690	broad.mit.edu	37	17	76047196	76047196	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:76047196G>A	uc002jud.2	+	4	2653	c.2053G>A	c.(2053-2055)GTG>ATG	p.V685M	TNRC6C_uc002juf.2_Missense_Mutation_p.V685M|TNRC6C_uc002jue.2_Missense_Mutation_p.V685M	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	685	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCTGCTTCTGTGAAACAGAC	0.552			NA											9	22					0	0	0.000978	0	0
TMC6	11322	broad.mit.edu	37	17	76113395	76113395	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:76113395C>A	uc002juj.1	-	17	2358	c.2232G>T	c.(2230-2232)CGG>CGT	p.R744R	TMC6_uc002jui.1_Silent_p.R323R|TMC6_uc010dhf.1_Silent_p.R577R|TMC6_uc002juk.2_Silent_p.R744R|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.R744R	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	744	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGCGCTGGCCCCGCACCACCT	0.682			NA							Epidermodysplasia_Verruciformis_Familial_Clustering_of				9	17					3.03607e-14	3.98415e-14	0.001368	1	0
METTL4	64863	broad.mit.edu	37	18	2566948	2566948	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:2566948G>A	uc002klh.3	-	2	1048	c.268C>T	c.(268-270)CCT>TCT	p.P90S		NM_022840	NP_073751	Q8N3J2	METL4_HUMAN	methyltransferase like 4	90					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			kidney(1)|skin(1)	2						AACAGTTCAGGTCGAAAAACA	0.368			NA											50	219					0	0	0.00361	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891215	2891215	+	Nonsense_Mutation	SNP	G	G	T	rs150535335	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:2891215G>T	uc002kln.2	+	4	1249	c.1090G>T	c.(1090-1092)GGA>TGA	p.G364*		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	364					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAGCTACCTGGGAGTGATAGA	0.522			NA											12	39					0.000219431	0.000239864	0.00245	1	0
NPC1	4864	broad.mit.edu	37	18	21140248	21140248	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:21140248G>A	uc002kum.3	-	6	1102	c.828C>T	c.(826-828)TAC>TAT	p.Y276Y	NPC1_uc010xaz.1_Silent_p.Y60Y|NPC1_uc010xba.1_Silent_p.Y121Y	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	276	Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAACGCCATGTAGGTGATCC	0.507			NA											12	207					0	0	0.001855	0	0
SETBP1	26040	broad.mit.edu	37	18	42533086	42533086	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:42533086A>G	uc010dni.2	+	4	4077	c.3781A>G	c.(3781-3783)AAA>GAA	p.K1261E		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1261						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CTCATGCACGAAAAGATACTC	0.537			NA							Schinzel-Giedion_syndrome				4	95					0	0	0.001984	0	0
SETBP1	26040	broad.mit.edu	37	18	42533120	42533120	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:42533120G>C	uc010dni.2	+	4	4111	c.3815G>C	c.(3814-3816)AGC>ACC	p.S1272T		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1272						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GATGGTGGCAGCACGAGATCA	0.532			NA							Schinzel-Giedion_syndrome				33	105					0	0	0.002836	0	0
MAPK4	5596	broad.mit.edu	37	18	48190638	48190638	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:48190638G>A	uc002lev.2	+	2	1310	c.310G>A	c.(310-312)GTC>ATC	p.V104I	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.V104I	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	104	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGCGTACATCGTCCAGGAGTA	0.612			NA											19	200					0	0	0.008871	0	0
DCC	1630	broad.mit.edu	37	18	50683801	50683801	+	Missense_Mutation	SNP	G	G	A	rs138053380		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:50683801G>A	uc002lfe.1	+	8	1924	c.1337G>A	c.(1336-1338)CGT>CAT	p.R446H	DCC_uc010xdr.1_Missense_Mutation_p.R294H|DCC_uc010dpf.1_Missense_Mutation_p.R101H	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	446	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CGATTTGTCCGTCTCAGCTGG	0.517			NA											13	521					0	0	0.00245	0	0
ALPK2	115701	broad.mit.edu	37	18	56203934	56203934	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:56203934G>T	uc002lhj.3	-	5	3699	c.3485C>A	c.(3484-3486)GCT>GAT	p.A1162D	ALPK2_uc002lhk.1_Missense_Mutation_p.A493D	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1162							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CTCTTGTGCAGCAGATGTCGT	0.577			NA											21	76					2.81731e-10	3.44197e-10	0.002096	1	0
ALPK2	115701	broad.mit.edu	37	18	56247124	56247124	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:56247124G>C	uc002lhj.3	-	4	1098	c.884C>G	c.(883-885)CCC>CGC	p.P295R		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	295							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CTGTGGGCTGGGTTGTTTGTT	0.488			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	111					0	0	0.001984	0	0
KIAA1468	57614	broad.mit.edu	37	18	59942667	59942667	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:59942667T>A	uc002lil.2	+	22	3143	c.2928T>A	c.(2926-2928)ACT>ACA	p.T976T	KIAA1468_uc002lik.1_Silent_p.T972T|KIAA1468_uc010xel.1_Silent_p.T976T|KIAA1468_uc002lim.2_Silent_p.T654T	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	976							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				TTGTCCATACTTCAGCACTCG	0.363			NA											39	102					0	0	0.00361	0	0
SERPINB12	89777	broad.mit.edu	37	18	61231212	61231212	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:61231212T>A	uc010xen.1	+	5	504	c.504T>A	c.(502-504)GGT>GGA	p.G168G	SERPINB12_uc010xeo.1_Silent_p.G188G	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	168					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						TTTTTTTAGGTAAAATCAAGG	0.308			NA											32	429					0	0	0.007835	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564585	66564585	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:66564585G>C	uc002lkk.2	+	8	1406	c.1183G>C	c.(1183-1185)GAT>CAT	p.D395H	CCDC102B_uc002lki.2_Missense_Mutation_p.D395H|CCDC102B_uc002lkj.1_Missense_Mutation_p.D395H	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	395	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGAGCTTTTGGATAAGAAAAA	0.408			NA											8	104					0	0	0.004482	0	0
RTTN	25914	broad.mit.edu	37	18	67718658	67718658	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:67718658G>A	uc002lkp.2	-	39	5380	c.5312C>T	c.(5311-5313)ACA>ATA	p.T1771I	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.T859I|RTTN_uc010dqp.2_Missense_Mutation_p.T23I	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1771							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AATCGCCGCTGTCCAGTGCTT	0.453			NA											13	429					0	0	0.008871	0	0
NETO1	81832	broad.mit.edu	37	18	70423369	70423369	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:70423369G>T	uc002lkw.2	-	8	1166	c.882C>A	c.(880-882)GGC>GGA	p.G294G	NETO1_uc002lkx.1_Silent_p.G293G|NETO1_uc002lky.1_Silent_p.G294G	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	294	LDL-receptor class A.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGAATGTGTTGCCTTCACAAG	0.343			NA											90	298					8.2166e-39	1.36732e-38	0.00361	1	0
ZNF236	7776	broad.mit.edu	37	18	74617253	74617253	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:74617253G>T	uc002lmi.2	+	13	2371	c.2173G>T	c.(2173-2175)GGT>TGT	p.G725C	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	725	C2H2-type 16.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TTTCACTACTGGTGGCAGCTT	0.438			NA											4	63					3.59834e-05	3.98177e-05	0.001168	1	0
ZNF236	7776	broad.mit.edu	37	18	74672732	74672732	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:74672732C>G	uc002lmi.2	+	30	5532	c.5334C>G	c.(5332-5334)TAC>TAG	p.Y1778*	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1778	C2H2-type 30.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AGCGGCCCTACAAGTGTGCCT	0.587			NA											4	95					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9047921	9047921	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:9047921G>T	uc002mkp.2	-	5	33914	c.33710C>A	c.(33709-33711)TCA>TAA	p.S11237*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11239	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCGACCCATGAGTCTATGGT	0.483			NA											49	211					6.60958e-23	9.80542e-23	0.00361	1	0
QTRT1	81890	broad.mit.edu	37	19	10822872	10822872	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:10822872G>C	uc002mpr.2	+	6	707	c.682G>C	c.(682-684)GGG>CGG	p.G228R	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	228					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CTTCGCCATCGGGGGCCTGAG	0.617			NA											10	13					0	0	0.00245	0	0
IL27RA	9466	broad.mit.edu	37	19	14153294	14153294	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:14153294G>T	uc002mxx.2	+	5	987	c.564G>T	c.(562-564)CTG>CTT	p.L188L		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	188	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCATACCCCTGACCCCTGTTG	0.542	Colon(164;1849 1896 4443 37792 47834)		NA									OREG0025302	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	71					4.26978e-12	5.41239e-12	0.00333	1	0
CYP4F3	4051	broad.mit.edu	37	19	15759996	15759996	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:15759996G>T	uc002nbj.2	+	6	602	c.552G>T	c.(550-552)GAG>GAT	p.E184D	CYP4F3_uc010xok.1_Missense_Mutation_p.E184D|CYP4F3_uc010xol.1_Missense_Mutation_p.E184D|CYP4F3_uc010xom.1_Missense_Mutation_p.E35D|CYP4F3_uc002nbk.2_Missense_Mutation_p.E184D|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	184				EGS -> KGY (in Ref. 3; AAC08589).	leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TGGCCTCAGAGGGTAGTGCCC	0.557			NA											55	166					4.10029e-35	6.63915e-35	0.00361	1	0
CYP4F12	66002	broad.mit.edu	37	19	15794437	15794437	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:15794437G>A	uc002nbl.2	+	7	843	c.782G>A	c.(781-783)CGC>CAC	p.R261H		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AGGGCCTGCCGCCTGGTGCAT	0.552			NA											11	197					0	0	0.003163	0	0
USHBP1	83878	broad.mit.edu	37	19	17373540	17373540	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:17373540C>T	uc002nfs.1	-	4	576	c.463G>A	c.(463-465)GGG>AGG	p.G155R	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.G91R|USHBP1_uc010eam.1_Missense_Mutation_p.G83R	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	155							PDZ domain binding			ovary(1)	1						CCTGCTCCCCCTTCGCTTGTG	0.687			NA											25	10					0	0	0.009535	0	0
CD22	933	broad.mit.edu	37	19	35836516	35836516	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:35836516C>A	uc010edt.2	+	12	2297	c.2220C>A	c.(2218-2220)GCC>GCA	p.A740A	CD22_uc010xst.1_Silent_p.A568A|CD22_uc010edu.2_Silent_p.A652A|CD22_uc010edv.2_Intron|CD22_uc002nzb.3_Silent_p.A563A|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	740	Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTAGAAGGGCCCCCCTCTCTG	0.582	Ovarian(42;1009 1133 23674 26041)		NA											22	21					9.90768e-06	1.11345e-05	0.004656	1	0
ATP4A	495	broad.mit.edu	37	19	36044671	36044671	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:36044671G>T	uc002oal.1	-	17	2571	c.2542C>A	c.(2542-2544)CGC>AGC	p.R848S	ATP4A_uc010eee.1_Missense_Mutation_p.R6S	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	848	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TTTGGGTTGCGTGGACGCAGG	0.607			NA											4	16					1.23904e-05	1.38814e-05	0.000602	1	0
DLL3	10683	broad.mit.edu	37	19	39989617	39989617	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:39989617G>T	uc002olx.2	+	1	61	c.3G>T	c.(1-3)ATG>ATT	p.M1I	DLL3_uc010egq.2_Missense_Mutation_p.M1I|DLL3_uc002olw.2_Missense_Mutation_p.M1I	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	1					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGAAGGCCATGGTCTCCCCAC	0.642			NA											5	28					0.000602214	0.000648446	0.000602	1	0
FCGBP	8857	broad.mit.edu	37	19	40433455	40433455	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:40433455G>T	uc002omp.3	-	2	822	c.814C>A	c.(814-816)CAG>AAG	p.Q272K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	272	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TTTGTGGCCTGGCTGGCCACA	0.602			NA											13	49					3.45872e-05	3.83513e-05	0.004007	1	0
ATP1A3	478	broad.mit.edu	37	19	42471882	42471882	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:42471882C>A	uc002osg.2	-	21	3007	c.2853G>T	c.(2851-2853)GAG>GAT	p.E951D	ATP1A3_uc010xwf.1_Missense_Mutation_p.E962D|ATP1A3_uc010xwg.1_Missense_Mutation_p.E921D|ATP1A3_uc010xwh.1_Missense_Mutation_p.E964D|ATP1A3_uc002osh.2_Missense_Mutation_p.E951D	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	951	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						CCAGGGCCGTCTCCTCAAACA	0.667			NA											9	28					1.05317e-09	1.27086e-09	0.00245	1	0
PSG7	5676	broad.mit.edu	37	19	43430713	43430713	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:43430713G>A	uc002ovl.3	-	5	967	c.865C>T	c.(865-867)CGC>TGC	p.R289C	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.R167C	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	289	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTTTCAATGCGTCGCTTTACC	0.493			NA											86	453					0	0	0.00361	0	0
ZNF285	26974	broad.mit.edu	37	19	44891467	44891467	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:44891467T>A	uc002ozd.3	-	4	1027	c.940A>T	c.(940-942)AAA>TAA	p.K314*	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Nonsense_Mutation_p.K321*	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TTGTAGGGTTTGTCTCCTGAG	0.502			NA											17	132					0	0	0.010504	0	0
SULT2A1	6822	broad.mit.edu	37	19	48377943	48377943	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:48377943A>T	uc002phr.2	-	5	856	c.716T>A	c.(715-717)GTA>GAA	p.V239E		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	239					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		TTTGTCCACTACATAATCAAC	0.403			NA											31	84					0	0	0.005524	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945446	48945446	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:48945446T>A	uc002pjc.3	+	12	2568	c.2480T>A	c.(2479-2481)ATC>AAC	p.I827N	GRIN2D_uc010elx.2_Missense_Mutation_p.I62N	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	827	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CTCTCTGGGATCTGCCACAAT	0.567			NA											17	55					0	0	0.008871	0	0
TRPM4	54795	broad.mit.edu	37	19	49704042	49704042	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:49704042G>T	uc002pmw.2	+	19	3025	c.2953G>T	c.(2953-2955)GTG>TTG	p.V985L	TRPM4_uc010emu.2_Missense_Mutation_p.V840L|TRPM4_uc010yak.1_Missense_Mutation_p.V449L|TRPM4_uc002pmx.2_Missense_Mutation_p.V811L|TRPM4_uc010emv.2_Missense_Mutation_p.V870L|TRPM4_uc010yal.1_Missense_Mutation_p.V631L|TRPM4_uc002pmy.2_Missense_Mutation_p.V327L	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	985	Selectivity filter.			EDMDVA->TIIDGP: Induces a functional channel that combines the gating hallmarks of TRPM4 (activation by Ca(2+)) with TRPV6-like sensitivity to block by extracellular Ca(2+) and Mg(2+) as well as Ca(2+) permeation.	dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGACATGGACGGTAGGGGGGA	0.592			NA											7	15					0.000442599	0.000479446	0.006214	1	0
IRF3	3661	broad.mit.edu	37	19	50163052	50163052	+	Silent	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:50163052G>C	uc010end.1	-	8	1519	c.1137C>G	c.(1135-1137)GCC>GCG	p.A379A	IRF3_uc002pos.1_RNA|IRF3_uc002pot.1_Silent_p.A252A|IRF3_uc002pox.1_Missense_Mutation_p.P341A|IRF3_uc002poy.1_Silent_p.A379A|IRF3_uc002pou.2_Silent_p.A379A|IRF3_uc002pov.2_Silent_p.A233A|IRF3_uc002pow.2_Missense_Mutation_p.P385A	NM_001571	NP_001562	Q14653	IRF3_HUMAN	interferon regulatory factor 3	379					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		CCCCTACCCGGGCCATTTCTA	0.607			NA											3	23					0	0	0.009096	0	0
MYH14	79784	broad.mit.edu	37	19	50779265	50779265	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:50779265G>C	uc002prr.1	+	26	3409	c.3362G>C	c.(3361-3363)GGG>GCG	p.G1121A	MYH14_uc010enu.1_Missense_Mutation_p.G1162A|MYH14_uc002prq.1_Missense_Mutation_p.G1129A	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1121	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GACGAGGGTGGGGCCCGGGCC	0.647			NA											3	14					0	0	0.004672	0	0
KLK4	9622	broad.mit.edu	37	19	51412025	51412025	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51412025C>A	uc002pua.1	-	3	285	c.285G>T	c.(283-285)CAG>CAT	p.Q95H	KLK4_uc002pty.1_Missense_Mutation_p.Q46H|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_5'UTR|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_5'UTR|KLK4_uc002pud.1_5'UTR	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	95	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CCTCCACCATCTGGCTCCCTG	0.597			NA											61	129					4.88506e-25	7.42034e-25	0.00361	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51630332	51630332	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51630332G>T	uc002pvu.2	+	4	861	c.794G>T	c.(793-795)GGC>GTC	p.G265V	SIGLEC9_uc010yct.1_Missense_Mutation_p.G265V	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	265	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTCCCAGAGGGCCAGTCTCTG	0.443			NA											50	86					1.40369e-38	2.3287e-38	0.00361	1	0
IGLON5	402665	broad.mit.edu	37	19	51828677	51828677	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51828677G>T	uc002pwc.2	+	4	469	c.469G>T	c.(469-471)GTG>TTG	p.V157L		NM_001101372	NP_001094842	A6NGN9	IGLO5_HUMAN	IgLON family member 5 precursor	157	Ig-like C2-type 2.					extracellular region					0						TTGCCTGGCCGTGGGGCGGCC	0.667			NA											11	20					6.72482e-11	8.32891e-11	0.003163	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51914385	51914385	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51914385G>A	uc002pwo.2	-	11	2678	c.2062C>T	c.(2062-2064)CAG>TAG	p.Q688*	SIGLEC10_uc002pwp.2_Nonsense_Mutation_p.Q630*|SIGLEC10_uc002pwq.2_Nonsense_Mutation_p.Q535*|SIGLEC10_uc002pwr.2_Nonsense_Mutation_p.Q593*|SIGLEC10_uc010ycy.1_Nonsense_Mutation_p.Q503*|SIGLEC10_uc010ycz.1_Nonsense_Mutation_p.Q545*|SIGLEC10_uc010eow.2_Nonsense_Mutation_p.Q405*	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	688	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TAATCCGCCTGGGTGCCCTTG	0.562			NA											30	24					0	0	0.009535	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51961521	51961521	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51961521G>T	uc002pwt.2	-	1	188	c.121C>A	c.(121-123)CTG>ATG	p.L41M	SIGLEC8_uc010yda.1_Missense_Mutation_p.L41M|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.L41M	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	41	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGACACACAGGCCCTCCTGC	0.552			NA											37	136					2.24893e-16	3.0706e-16	0.009718	1	0
CEACAM18	729767	broad.mit.edu	37	19	51986279	51986279	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:51986279G>C	uc002pwv.1	+	5	865	c.865G>C	c.(865-867)GAC>CAC	p.D289H		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	289	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGATGGGCCCGACTATGTGCT	0.552			NA											76	214					0	0	0.00361	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52719903	52719903	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:52719903A>T	uc002pyp.2	+	9	1274	c.1115A>T	c.(1114-1116)CAG>CTG	p.Q372L	PPP2R1A_uc010ydk.1_Missense_Mutation_p.Q317L|PPP2R1A_uc010epm.1_Missense_Mutation_p.Q412L|PPP2R1A_uc002pyq.2_Missense_Mutation_p.Q193L	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	372	PP2A subunit B binding.|HEAT 10.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TTCCTGGCTCAGCTGAAGGAT	0.552			NA	Mis		clear cell ovarian carcinoma								28	77					0	0	0.003271	0	0
TFPT	29844	broad.mit.edu	37	19	54618637	54618637	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:54618637G>C	uc010yej.1	-	1	419	c.13C>G	c.(13-15)CAG>GAG	p.Q5E	TFPT_uc010erd.2_Missense_Mutation_p.Q5E|PRPF31_uc002qdh.2_5'Flank|PRPF31_uc010yek.1_5'Flank	NM_013342	NP_037474	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner	5					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding				0	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					CCTTCTCTCTGCTCCAATTCC	0.522			NA	T	TCF3	pre-B ALL						OREG0003635|OREG0003633	type=REGULATORY REGION|Gene=PRPF31|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=TFPT|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	8	35					0	0	0.008291	0	0
LILRB1	10859	broad.mit.edu	37	19	55146212	55146212	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:55146212C>A	uc002qgj.2	+	11	1821	c.1481C>A	c.(1480-1482)TCG>TAG	p.S494*	LILRB1_uc010erp.1_Nonsense_Mutation_p.S109*|LILRB1_uc002qgl.2_Nonsense_Mutation_p.S494*|LILRB1_uc002qgk.2_Nonsense_Mutation_p.S495*|LILRB1_uc002qgm.2_Nonsense_Mutation_p.S495*|LILRB1_uc010erq.2_Nonsense_Mutation_p.S478*|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	494	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CACTGGACATCGAGTGAGTAG	0.453			NA								HNSCC(37;0.09)			74	178					5.82064e-54	1.03223e-53	0.00361	1	0
NLRP2	55655	broad.mit.edu	37	19	55497607	55497607	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:55497607G>T	uc002qij.2	+	8	2376	c.2290G>T	c.(2290-2292)GGC>TGC	p.G764C	NLRP2_uc010yfp.1_Missense_Mutation_p.G741C|NLRP2_uc010esn.2_Missense_Mutation_p.G740C|NLRP2_uc010eso.2_Missense_Mutation_p.G761C|NLRP2_uc010esp.2_Missense_Mutation_p.G742C	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	764					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACCCTTCAAGGCAATGACCA	0.443			NA											17	38					6.94344e-10	8.41629e-10	0.006122	1	0
NLRP4	147945	broad.mit.edu	37	19	56369376	56369376	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:56369376C>A	uc002qmd.3	+	3	1039	c.617C>A	c.(616-618)TCC>TAC	p.S206Y	NLRP4_uc002qmf.2_Missense_Mutation_p.S131Y|NLRP4_uc010etf.2_Missense_Mutation_p.S37Y	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	206	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACTTGATTTCCAGAGAGTGG	0.532			NA											28	120					4.74835e-14	6.22357e-14	0.002096	1	0
NLRP4	147945	broad.mit.edu	37	19	56370026	56370026	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:56370026G>T	uc002qmd.3	+	3	1689	c.1267G>T	c.(1267-1269)GGG>TGG	p.G423W	NLRP4_uc002qmf.2_Missense_Mutation_p.G348W|NLRP4_uc010etf.2_Missense_Mutation_p.G254W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	423	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCGGAGAAATGGGGTTGTTGA	0.562			NA											37	148					1.32136e-16	1.8133e-16	0.00874	1	0
ZNF419	79744	broad.mit.edu	37	19	58005013	58005013	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:58005013G>A	uc002qov.2	+	5	1328	c.1088G>A	c.(1087-1089)CGT>CAT	p.R363H	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.R364H|ZNF419_uc010etz.1_Missense_Mutation_p.R351H|ZNF419_uc010eua.1_Missense_Mutation_p.R350H|ZNF419_uc002qow.2_Missense_Mutation_p.R331H|ZNF419_uc010eub.1_Missense_Mutation_p.R318H|ZNF419_uc010euc.1_Missense_Mutation_p.R317H	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	363	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		AAACATTGGCGTGTTCATACT	0.413			NA											4	105					0	0	0.009096	0	0
TPO	7173	broad.mit.edu	37	2	1544403	1544403	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:1544403G>A	uc002qww.2	+	16	2747	c.2656G>A	c.(2656-2658)GAG>AAG	p.E886K	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.E829K|TPO_uc002qwr.2_Missense_Mutation_p.E886K|TPO_uc002qwx.2_Missense_Mutation_p.E829K|TPO_uc010yio.1_Missense_Mutation_p.E713K|TPO_uc010yip.1_Missense_Mutation_p.E842K|TPO_uc002qwy.1_Missense_Mutation_p.E182K|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	886	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCCCATCTCGGAGACAGGCGG	0.642			NA											10	55					0	0	0.000978	0	0
TRIB2	28951	broad.mit.edu	37	2	12880889	12880890	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:12880889_12880890TG>AT	uc002rbv.3	+	3	2437_2438	c.1001_1002TG>AT	c.(1000-1002)ATG>AAT	p.M334N	TRIB2_uc010yjp.1_Missense_Mutation_p.M198N	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	334					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GACGTCAACATGGAAGAGAACT	0.515			NA											49	180					0	0	0.004672	0	0
NBAS	51594	broad.mit.edu	37	2	15417226	15417226	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:15417226C>A	uc002rcc.1	-	43	5165	c.5139_splice	c.e43-1	p.G1713_splice	NBAS_uc010exl.1_Splice_Site_p.G785_splice|NBAS_uc002rcd.1_Splice_Site	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4						TGTGGACAAACTGAAATTAAG	0.358			NA											10	79					0.000151284	0.000166044	0.001855	1	0
NBAS	51594	broad.mit.edu	37	2	15468435	15468435	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:15468435C>A	uc002rcc.1	-	37	4375	c.4349G>T	c.(4348-4350)GGG>GTG	p.G1450V	NBAS_uc010exl.1_Missense_Mutation_p.G522V|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1450										ovary(2)|liver(1)|skin(1)	4						ACATTTTTGCCCCTaaaaaga	0.209			NA											78	457					8.60386e-38	1.423e-37	0.00361	1	0
VSNL1	7447	broad.mit.edu	37	2	17836616	17836616	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:17836616C>A	uc002rcm.2	+	4	915	c.531C>A	c.(529-531)AGC>AGA	p.S177R		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	177	EF-hand 4.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTGCAAAGAGCGACCCTTCCA	0.443			NA											35	318					6.07928e-31	9.65532e-31	0.009718	1	0
PUM2	23369	broad.mit.edu	37	2	20482749	20482749	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:20482749C>T	uc002rds.1	-	11	1702	c.1679G>A	c.(1678-1680)GGT>GAT	p.G560D	PUM2_uc002rdt.1_Missense_Mutation_p.G560D|PUM2_uc002rdr.2_Missense_Mutation_p.G499D|PUM2_uc010yjy.1_Missense_Mutation_p.G560D|PUM2_uc002rdu.1_Missense_Mutation_p.G560D|PUM2_uc010yjz.1_Missense_Mutation_p.G499D	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	560	Ser-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATAGCAGCACCCAAAGAGTT	0.428			NA											20	84					0	0	0.002299	0	0
APOB	338	broad.mit.edu	37	2	21239499	21239499	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:21239499G>T	uc002red.2	-	21	3272	c.3144C>A	c.(3142-3144)ACC>ACA	p.T1048T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1048					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAATGTCATGGTAGCCTCAG	0.373			NA											29	250					2.48696e-23	3.69452e-23	0.003271	1	0
APOB	338	broad.mit.edu	37	2	21245902	21245902	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:21245902G>T	uc002red.2	-	18	2745	c.2617C>A	c.(2617-2619)CTG>ATG	p.L873M		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	873					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTGCCACCAGTTCAGCCTGC	0.473			NA											10	103					9.31168e-06	1.04756e-05	0.001855	1	0
SLC30A3	7781	broad.mit.edu	37	2	27481082	27481082	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:27481082C>T	uc002rjk.2	-	3	557	c.371G>A	c.(370-372)TGG>TAG	p.W124*	SLC30A3_uc002rjj.2_5'UTR|SLC30A3_uc010ylh.1_Nonsense_Mutation_p.W119*	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	124	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGAGAGCCAGAGGGAGAA	0.637			NA											7	22					0	0	0.004482	0	0
BRE	9577	broad.mit.edu	37	2	28464261	28464261	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:28464261G>T	uc002rlr.2	+	10	1169	c.851_splice	c.e10+1	p.T284_splice	BRE_uc002rlp.1_Splice_Site_p.T284_splice|BRE_uc002rlq.2_Splice_Site_p.T284_splice|BRE_uc002rls.2_Splice_Site_p.T284_splice|BRE_uc002rlt.2_Splice_Site_p.T284_splice|BRE_uc002rlu.2_Splice_Site_p.T284_splice|BRE_uc002rlv.2_Splice_Site_p.T146_splice	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A						apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					ACTTTGGCACGTAAGTTCTGC	0.438			NA											14	189					1.33834e-09	1.61138e-09	0.007413	1	0
PLB1	151056	broad.mit.edu	37	2	28855858	28855858	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:28855858C>A	uc002rmb.1	+	56	4050	c.4050C>A	c.(4048-4050)TTC>TTA	p.F1350L	PLB1_uc010ezj.1_Missense_Mutation_p.F1339L|PLB1_uc002rme.1_Missense_Mutation_p.F315L|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	1350	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|4.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GTTTTCACTTCTCAGACCGCG	0.562			NA											30	264					1.69901e-12	2.17409e-12	0.005524	1	0
PLB1	151056	broad.mit.edu	37	2	28855888	28855888	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:28855888C>T	uc002rmb.1	+	56	4080	c.4080C>T	c.(4078-4080)ATC>ATT	p.I1360I	PLB1_uc010ezj.1_Silent_p.I1349I|PLB1_uc002rme.1_Silent_p.I325I|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	1360	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|4.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					AGATGGCCATCGCACTCTGGA	0.547			NA											30	196					0	0	0.003271	0	0
ALK	238	broad.mit.edu	37	2	29551271	29551271	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:29551271C>A	uc002rmy.2	-	6	2266	c.1359G>T	c.(1357-1359)CAG>CAT	p.Q453H		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	453	LDL-receptor class A.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGTCACAGGCCTGCCCAAGCT	0.607			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				12	116					2.80697e-09	3.36837e-09	0.000978	1	0
NLRC4	58484	broad.mit.edu	37	2	32477681	32477681	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:32477681G>T	uc002roi.2	-	3	315	c.69C>A	c.(67-69)ATC>ATA	p.I23I	NLRC4_uc002roj.1_Silent_p.I23I|NLRC4_uc010ezt.1_Silent_p.I23I	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	23	LRR 1.|CARD.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGTCATCTGTGATTTGCTTTA	0.393			NA											112	317					6.14176e-70	1.1476e-69	0.00361	1	0
LTBP1	4052	broad.mit.edu	37	2	33359928	33359928	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:33359928G>T	uc002ros.2	+	5	1102	c.1102G>T	c.(1102-1104)GGC>TGC	p.G368C	LTBP1_uc002rot.2_Missense_Mutation_p.G42C|LTBP1_uc002rou.2_Missense_Mutation_p.G42C|LTBP1_uc002rov.2_Missense_Mutation_p.G42C|LTBP1_uc010ymz.1_Missense_Mutation_p.G42C|LTBP1_uc010yna.1_Missense_Mutation_p.G42C	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	368					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTGCACCAAGGGCAGCTGTCA	0.547			NA											67	192					6.5469e-37	1.07457e-36	0.00361	1	0
LRPPRC	10128	broad.mit.edu	37	2	44145419	44145419	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:44145419C>G	uc002rtr.2	-	28	3073	c.3015G>C	c.(3013-3015)CAG>CAC	p.Q1005H	LRPPRC_uc010yob.1_Missense_Mutation_p.Q905H	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1005					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ACGGAACTTCCTGGTTACCCT	0.338			NA											33	121					0	0	0.00361	0	0
LHCGR	3973	broad.mit.edu	37	2	48941147	48941147	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:48941147T>G	uc002rwu.3	-	7	653	c.583A>C	c.(583-585)AAT>CAT	p.N195H	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	195	LRR 4.|Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTCGTCCCATTGAATGCATGA	0.378			NA							Familial_Male-Limited_Precocious_Puberty				22	198					0	0	0.007291	0	0
SPTBN1	6711	broad.mit.edu	37	2	54893182	54893182	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:54893182G>T	uc002rxu.2	+	34	7039	c.6790G>T	c.(6790-6792)GTG>TTG	p.V2264L	SPTBN1_uc010you.1_Missense_Mutation_p.V254L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2264	PH.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			TGTCTGCGAAGTGGCCCTTGA	0.468			NA											29	349					3.67414e-24	5.52656e-24	0.002445	1	0
USP34	9736	broad.mit.edu	37	2	61505418	61505418	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:61505418C>A	uc002sbe.2	-	41	5337	c.5315G>T	c.(5314-5316)AGG>ATG	p.R1772M	USP34_uc002sbf.2_Translation_Start_Site	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1772					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			AAGGATCTCCCTACTACAAAA	0.338			NA											27	81					1.61788e-16	2.21178e-16	0.002445	1	0
ARHGAP25	9938	broad.mit.edu	37	2	69049651	69049651	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:69049651C>A	uc002seu.2	+	10	1741	c.1377C>A	c.(1375-1377)AGC>AGA	p.S459R	ARHGAP25_uc010fdg.2_Missense_Mutation_p.S460R|ARHGAP25_uc010yql.1_Missense_Mutation_p.S420R|ARHGAP25_uc002sew.2_Missense_Mutation_p.S452R|ARHGAP25_uc002sex.2_Missense_Mutation_p.S453R|ARHGAP25_uc002sey.2_Missense_Mutation_p.S186R	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	459					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GTGCCAACAGCAGCAAAATGG	0.478			NA											26	162					2.47511e-08	2.91825e-08	0.008361	1	0
ALMS1	7840	broad.mit.edu	37	2	73827999	73827999	+	Missense_Mutation	SNP	T	T	G	rs45528134		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:73827999T>G	uc002sje.1	+	20	11977	c.11866T>G	c.(11866-11868)TCC>GCC	p.S3956A	ALMS1_uc002sjf.1_Missense_Mutation_p.S3912A|ALMS1_uc002sjh.1_Missense_Mutation_p.S3342A	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3954					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CAAGAAGAATTCCCATGAAGG	0.403			NA											7	54					0	0	0.001882	0	0
C2orf78	388960	broad.mit.edu	37	2	74043181	74043181	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:74043181C>A	uc002sjr.1	+	3	1952	c.1831C>A	c.(1831-1833)CAA>AAA	p.Q611K		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	611	Lys-rich.									ovary(2)	2						GAAGAAAAATCAACCTGAGCT	0.438			NA											35	118					4.90274e-10	5.96279e-10	0.00623	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745831	77745831	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:77745831G>A	uc002snr.2	-	3	1579	c.1164C>T	c.(1162-1164)ACC>ACT	p.T388T	LRRTM4_uc002snq.2_Silent_p.T388T|LRRTM4_uc002sns.2_Silent_p.T388T|LRRTM4_uc002snt.2_Silent_p.T389T	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	388	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GTTTGAAGATGGTAGGTCTAG	0.473			NA											16	58					0	0	0.008871	0	0
REG3A	5068	broad.mit.edu	37	2	79384728	79384728	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:79384728C>T	uc002sod.1	-	4	685	c.430G>A	c.(430-432)GGC>AGC	p.G144S	REG3A_uc002soe.1_Missense_Mutation_p.G144S|REG3A_uc002sof.1_Missense_Mutation_p.G144S	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	144	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GCACAGTGGCCGGGGCTTGAG	0.542			NA											8	233					0	0	0.00308	0	0
REG3A	5068	broad.mit.edu	37	2	79384784	79384784	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:79384784C>A	uc002sod.1	-	4	629	c.374G>T	c.(373-375)AGT>ATT	p.S125I	REG3A_uc002soe.1_Missense_Mutation_p.S125I|REG3A_uc002sof.1_Missense_Mutation_p.S125I	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	125	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						CATCACATCACTGCTACTCCA	0.542			NA											67	225					1.34568e-36	2.19868e-36	0.00361	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530120	80530120	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:80530120C>A	uc002sok.1	-	2	1095	c.825G>T	c.(823-825)GTG>GTT	p.V275V	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	275	LRR 8.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CGGTCTCGAACACATGGGGCT	0.582			NA								HNSCC(69;0.2)			8	28					0.00448238	0.00470454	0.004482	1	0
CTNNA2	1496	broad.mit.edu	37	2	80816575	80816575	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:80816575G>T	uc010ysh.1	+	14	2159	c.2154G>T	c.(2152-2154)ATG>ATT	p.M718I	CTNNA2_uc010yse.1_Missense_Mutation_p.M718I|CTNNA2_uc010ysf.1_Missense_Mutation_p.M718I|CTNNA2_uc010ysg.1_Missense_Mutation_p.M718I|CTNNA2_uc010ysi.1_Missense_Mutation_p.M350I|CTNNA2_uc010ysj.1_Missense_Mutation_p.M47I	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	718					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCAAGCAGATGTGTATGATCA	0.458			NA											106	408					3.6033e-41	6.0522e-41	0.00361	1	0
KDM3A	55818	broad.mit.edu	37	2	86678331	86678331	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:86678331A>G	uc002sri.3	+	4	775	c.448A>G	c.(448-450)ATA>GTA	p.I150V	KDM3A_uc010ytj.1_Missense_Mutation_p.I150V|KDM3A_uc010ytk.1_Missense_Mutation_p.I98V	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	150					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						TTTGAAGCCTATACAGGTAAA	0.313	NSCLC(96;1150 1523 6936 46253 49736)		NA											7	53					0	0	0.00308	0	0
KDM3A	55818	broad.mit.edu	37	2	86718115	86718115	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:86718115C>T	uc002sri.3	+	24	4012	c.3685C>T	c.(3685-3687)CAA>TAA	p.Q1229*	KDM3A_uc010ytj.1_Nonsense_Mutation_p.Q1229*|KDM3A_uc010ytk.1_Nonsense_Mutation_p.Q1177*	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	1229	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GTATGGAGTTCAAGGCTGGGC	0.423	NSCLC(96;1150 1523 6936 46253 49736)		NA											58	520					0	0	0.00361	0	0
PROM2	150696	broad.mit.edu	37	2	95945675	95945675	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:95945675G>T	uc002suh.1	+	11	1490	c.1357G>T	c.(1357-1359)GGC>TGC	p.G453C	PROM2_uc002sui.2_Missense_Mutation_p.G453C|PROM2_uc002suj.2_Missense_Mutation_p.G107C|PROM2_uc002suk.2_Missense_Mutation_p.G453C|PROM2_uc002sul.2_5'UTR|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	453	Cytoplasmic (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGGCATCTGGGGCCTGTCTGC	0.642			NA											3	26					0.004672	0.00487985	0.004672	1	0
ASTL	431705	broad.mit.edu	37	2	96801117	96801117	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:96801117G>C	uc010yui.1	-	3	216	c.216C>G	c.(214-216)TTC>TTG	p.F72L		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	72					proteolysis		metalloendopeptidase activity|zinc ion binding				0						CCTCGATGAGGAAGCTGCTCT	0.607			NA											4	22					0	0	0.001168	0	0
STARD7	56910	broad.mit.edu	37	2	96858109	96858109	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:96858109C>G	uc002svm.3	-	6	1242	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	STARD7_uc002svl.2_Missense_Mutation_p.E59Q	NM_020151	NP_064536	Q9NQZ5	STAR7_HUMAN	START domain containing 7 precursor	281	START.					mitochondrion					0						AAACTCACCTCATCAAATGAC	0.433			NA											78	241					0	0	0.00361	0	0
MRPL30	51263	broad.mit.edu	37	2	99804653	99804653	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:99804653G>T	uc002szu.2	+	3	227	c.65G>T	c.(64-66)GGT>GTT	p.G22V	MRPL30_uc002szl.1_RNA|MRPL30_uc002szr.2_Missense_Mutation_p.G22V|MRPL30_uc002szt.1_Intron|MRPL30_uc002szv.2_Missense_Mutation_p.G22V	NM_145213	NP_660214	Q8TCC3	RM30_HUMAN	RecName: Full=39S ribosomal protein L30, mitochondrial;          Short=L30mt; AltName: Full=MRP-L30; AltName: Full=MRP-L28; Flags: Precursor;	22					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1						GTGACAAAAGGTGTGGAGTCT	0.313			NA											18	77					7.4402e-23	1.10225e-22	0.003954	1	0
REV1	51455	broad.mit.edu	37	2	100058928	100058928	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:100058928G>C	uc002tad.2	-	5	566	c.354C>G	c.(352-354)ATC>ATG	p.I118M	REV1_uc002tac.2_Missense_Mutation_p.I118M|REV1_uc002tae.1_Missense_Mutation_p.I97M	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	118	BRCT.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						GTCCAGCTTTGATGCTGAAAC	0.413			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					7	228					0	0	0.008291	0	0
SLC5A7	60482	broad.mit.edu	37	2	108604640	108604640	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:108604640C>A	uc002tdv.2	+	2	305	c.29C>A	c.(28-30)GCT>GAT	p.A10D	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.A10D|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	10	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGACTGATAGCTATCATCGTG	0.443			NA											49	162					7.91745e-34	1.27434e-33	0.00361	1	0
ZC3H6	376940	broad.mit.edu	37	2	113089158	113089158	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:113089158C>G	uc002thq.1	+	12	3057	c.2663C>G	c.(2662-2664)CCT>CGT	p.P888R		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	888							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						CTTCCAGTACCTTTACCTAAA	0.403			NA											20	69					0	0	0.001882	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257955	114257955	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:114257955A>T	uc002tjw.3	+	1	1295	c.1122A>T	c.(1120-1122)GGA>GGT	p.G374G		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	374					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CATCAGGAGGAGGACTGCGCC	0.687			NA											4	49					0	0	0.009096	0	0
CLASP1	23332	broad.mit.edu	37	2	122106236	122106236	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:122106236T>A	uc002tnc.2	-	37	4655	c.4265A>T	c.(4264-4266)CAG>CTG	p.Q1422L	CLASP1_uc010yyv.1_Missense_Mutation_p.Q468L|CLASP1_uc002tmz.2_Missense_Mutation_p.Q507L|CLASP1_uc002tna.2_Missense_Mutation_p.Q468L|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.Q1363L|CLASP1_uc010yza.1_Missense_Mutation_p.Q1355L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Missense_Mutation_p.Q258L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1422	Localization to kinetochores.|Interaction with PHLDB2 and RSN.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					CTTGATGCACTGCTCCGGGTG	0.587			NA											13	60					0	0	0.003163	0	0
TUBA3E	112714	broad.mit.edu	37	2	130951377	130951377	+	Missense_Mutation	SNP	C	C	G	rs148936100	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:130951377C>G	uc002tqv.2	-	4	1139	c.1038G>C	c.(1036-1038)TGG>TGC	p.W346C		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	346					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CAGTCGGGCACCAATCCACAA	0.542			NA											3	79					0	0	0.004672	0	0
NCKAP5	344148	broad.mit.edu	37	2	133554252	133554252	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:133554252C>A	uc002ttp.2	-	12	1232	c.858G>T	c.(856-858)GAG>GAT	p.E286D	NCKAP5_uc002ttq.2_Missense_Mutation_p.E286D	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	286							protein binding				0						TTCTTTCCACCTCTGAAAGCA	0.408			NA											8	88					0.000673444	0.000722264	0.008291	1	0
R3HDM1	23518	broad.mit.edu	37	2	136393555	136393555	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:136393555A>T	uc002tuo.2	+	10	1164	c.794A>T	c.(793-795)AAA>ATA	p.K265I	R3HDM1_uc010fni.2_Missense_Mutation_p.K263I|R3HDM1_uc002tup.2_Missense_Mutation_p.K209I|R3HDM1_uc010zbh.1_Missense_Mutation_p.K97I	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	265							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		AGCTTTGACAAAGATGATAAC	0.323			NA											42	141					0	0	0.00361	0	0
NEB	4703	broad.mit.edu	37	2	152512820	152512820	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:152512820G>A	uc010fnx.2	-	49	6533	c.6342C>T	c.(6340-6342)CAC>CAT	p.H2114H		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2114	Nebulin 56.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CGGCAGGGGTGTGGTAGCTGG	0.478			NA											95	290					0	0	0.00361	0	0
GALNT3	2591	broad.mit.edu	37	2	166606398	166606398	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:166606398C>T	uc010fph.1	-	10	2020	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	545	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						GCAGAGTATTCAAAGTACTAT	0.383			NA											16	513					0	0	0.008871	0	0
SCN1A	6323	broad.mit.edu	37	2	166896013	166896013	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:166896013C>A	uc010zcz.1	-	14	2494	c.2476G>T	c.(2476-2478)GGT>TGT	p.G826C	SCN1A_uc002udo.3_Missense_Mutation_p.G706C|SCN1A_uc010fpk.2_Missense_Mutation_p.G678C	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	837	II.|Helical; Name=S3 of repeat II; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ACAATAAAACCGTCAAAGATA	0.363			NA											19	88					7.41877e-09	8.85334e-09	0.001882	1	0
SCN9A	6335	broad.mit.edu	37	2	167133545	167133545	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:167133545T>A	uc010fpl.2	-	16	3130	c.2789A>T	c.(2788-2790)CAA>CTA	p.Q930L	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	941	II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCACATAGCTTGACCAGCGAC	0.448			NA											108	738					0	0	0.00361	0	0
TTC30B	150737	broad.mit.edu	37	2	178416257	178416257	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:178416257G>A	uc002uln.2	-	1	1268	c.1235C>T	c.(1234-1236)GCA>GTA	p.A412V	TTC30B_uc010zfc.1_Missense_Mutation_p.A184V	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	412	TPR 5.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			TTCATTCACTGCCTTTTTGAT	0.413			NA											10	658					0	0	0.003163	0	0
OSBPL6	114880	broad.mit.edu	37	2	179259071	179259071	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:179259071G>T	uc002ulx.2	+	24	2983	c.2605G>T	c.(2605-2607)GCA>TCA	p.A869S	OSBPL6_uc002uly.2_Missense_Mutation_p.A894S|OSBPL6_uc010zfe.1_Missense_Mutation_p.A838S|OSBPL6_uc002ulz.2_Missense_Mutation_p.A833S|OSBPL6_uc002uma.2_Missense_Mutation_p.A873S	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	869					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			AGAAGCTGCAGCATCAGAGAA	0.348			NA											59	171					2.72187e-29	4.2727e-29	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179443719	179443719	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:179443719T>C	uc010zfg.1	-	269	60558	c.60334A>G	c.(60334-60336)ATC>GTC	p.I20112V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I13807V|TTN_uc010zfi.1_Missense_Mutation_p.I13740V|TTN_uc010zfj.1_Missense_Mutation_p.I13615V|uc002umv.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21039							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTCTAGGATATAGTTGGTG	0.478			NA											11	86					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179592523	179592523	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:179592523C>T	uc010zfg.1	-	65	16274	c.16050G>A	c.(16048-16050)AAG>AAA	p.K5350K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.K2011K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6277							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAGTATTGCCTTAAATTCCA	0.373			NA											64	152					0	0	0.00361	0	0
SSFA2	6744	broad.mit.edu	37	2	182784139	182784139	+	Missense_Mutation	SNP	G	G	T	rs150716378	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:182784139G>T	uc002uoi.2	+	14	3432	c.3110G>T	c.(3109-3111)CGC>CTC	p.R1037L	SSFA2_uc002uoh.2_Missense_Mutation_p.R1037L|SSFA2_uc002uoj.2_Missense_Mutation_p.R1037L|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.R884L|SSFA2_uc002uol.2_Missense_Mutation_p.R884L|SSFA2_uc002uom.2_Missense_Mutation_p.R505L	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	1037	Potential.					cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			CGTGCTGTGCGCATGCCTTCA	0.532			NA											7	222					0.00448238	0.00470454	0.004482	1	0
FAM171B	165215	broad.mit.edu	37	2	187626258	187626258	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:187626258G>T	uc002ups.2	+	8	1301	c.1189G>T	c.(1189-1191)GTC>TTC	p.V397F	FAM171B_uc002upr.1_Missense_Mutation_p.V397F|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	397	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TAAACTTGAGGTCCTCAAGAG	0.358			NA											89	265					1.2136e-71	2.2755e-71	0.00361	1	0
COL3A1	1281	broad.mit.edu	37	2	189849689	189849689	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:189849689G>T	uc002uqj.1	+	2	399	c.282_splice	c.e2+1	p.A94_splice		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein						axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TCCAACTGCTGTGAGTTTAAA	0.388			NA											11	25					6.42651e-13	8.30219e-13	0.000978	1	0
COL3A1	1281	broad.mit.edu	37	2	189872628	189872628	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:189872628G>A	uc002uqj.1	+	46	3498	c.3381G>A	c.(3379-3381)CAG>CAA	p.Q1127Q		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1127	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGGTCAGCAGGGTGCAATCG	0.463			NA											61	74					0	0	0.00361	0	0
COL5A2	1290	broad.mit.edu	37	2	189904126	189904126	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:189904126G>A	uc002uqk.2	-	51	4072	c.3797C>T	c.(3796-3798)CCA>CTA	p.P1266L	COL5A2_uc010frx.2_Missense_Mutation_p.P842L	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1266	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ATGAACCCCTGGGTCCGTTTT	0.517			NA											24	48					0	0	0.005443	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172847	207172847	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:207172847G>A	uc002vbp.2	+	5	3845	c.3595G>A	c.(3595-3597)GTA>ATA	p.V1199I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1199							nucleic acid binding|zinc ion binding			ovary(3)	3						TGGTTCTGAAGTAAGTTTTGA	0.418			NA											5	174					0	0	0.00308	0	0
PTH2R	5746	broad.mit.edu	37	2	209302554	209302554	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:209302554C>A	uc002vdb.2	+	4	572	c.359C>A	c.(358-360)GCC>GAC	p.A120D	PTH2R_uc010zjb.1_Missense_Mutation_p.A131D	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	120	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		AAAACATGGGCCAATTATTCA	0.403			NA											12	176					1.99824e-07	2.31307e-07	0.00499	1	0
PECR	55825	broad.mit.edu	37	2	216923646	216923646	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:216923646G>A	uc002vft.2	-	4	546	c.478C>T	c.(478-480)CCT>TCT	p.P160S	PECR_uc010zjq.1_Intron|PECR_uc002vfr.2_Missense_Mutation_p.P22S|PECR_uc002vfs.2_Missense_Mutation_p.P14S	NM_018441	NP_060911	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase	160					fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity				0		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	GCTTTAGTAGGGACAATGATA	0.378			NA											33	74					0	0	0.007835	0	0
PLCD4	84812	broad.mit.edu	37	2	219492945	219492945	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:219492945A>T	uc002vij.1	+	7	1161	c.966A>T	c.(964-966)GGA>GGT	p.G322G	PLCD4_uc002vik.1_Silent_p.G169G|PLCD4_uc010zkk.1_Intron	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	322	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GCGTCGAGGGATATATACGGT	0.512			NA											9	190					0	0	0.001368	0	0
TTLL4	9654	broad.mit.edu	37	2	219611895	219611895	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:219611895G>A	uc002viy.2	+	9	2514	c.2144G>A	c.(2143-2145)CGC>CAC	p.R715H	TTLL4_uc010zkl.1_Missense_Mutation_p.R550H|TTLL4_uc010fvx.2_Intron|TTLL4_uc010zkm.1_5'UTR	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	715	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AGCAGCAGCCGCCAAAAGTGG	0.542	GBM(172;1818 2053 15407 20943 49753)		NA											3	37					0	0	0.004672	0	0
TUBA4B	80086	broad.mit.edu	37	2	220136384	220136384	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:220136384T>C	uc002vkv.1	+	4	854	c.689T>C	c.(688-690)TTA>TCA	p.L230S	TUBA4B_uc002vku.2_RNA	NR_003063				RecName: Full=Putative tubulin-like protein alpha-4B; AltName: Full=Alpha-tubulin 4B;												0						TGGCAGAGATTACCAATGCCT	0.552			NA											3	68					0	0	0.006214	0	0
SPEG	10290	broad.mit.edu	37	2	220353298	220353298	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:220353298G>T	uc010fwg.2	+	33	7937	c.7937G>T	c.(7936-7938)CGG>CTG	p.R2646L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2646	Ig-like 9.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCATCCCCCGGGCGGGCAAG	0.642			NA											4	13					1.024e-07	1.19172e-07	0.000602	1	0
CHPF	79586	broad.mit.edu	37	2	220404338	220404338	+	Missense_Mutation	SNP	C	C	G	rs149014949		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:220404338C>G	uc002vmc.3	-	4	2322	c.2095G>C	c.(2095-2097)GAG>CAG	p.E699Q	CHPF_uc010zlh.1_Missense_Mutation_p.E537Q	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	699	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCAGCTCCTCTTCTTGTTCT	0.647			NA											4	51					0	0	0.00308	0	0
SLC4A3	6508	broad.mit.edu	37	2	220496825	220496825	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:220496825G>A	uc002vmp.3	+	7	1216	c.947G>A	c.(946-948)CGG>CAG	p.R316Q	SLC4A3_uc002vmn.2_Missense_Mutation_p.R343Q|SLC4A3_uc002vmo.3_Missense_Mutation_p.R343Q|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	316	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGCTGGACCGGAGGCCTCAT	0.652			NA											5	11					0	0	0.001984	0	0
SCG2	7857	broad.mit.edu	37	2	224463262	224463262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:224463262C>A	uc002vnm.2	-	2	872	c.739G>T	c.(739-741)GGA>TGA	p.G247*		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	247					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CAGTCTTCTCCCCCGACCACA	0.413			NA											168	543					3.92034e-43	6.67819e-43	0.00361	1	0
DNER	92737	broad.mit.edu	37	2	230341871	230341871	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:230341871A>G	uc002vpv.2	-	7	1393	c.1246T>C	c.(1246-1248)TGC>CGC	p.C416R	DNER_uc010zly.1_Missense_Mutation_p.C144R	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	416	Extracellular (Potential).|EGF-like 5.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GGACACTGGCAGGTGAATCCA	0.378			NA											17	66					0	0	0.007835	0	0
RBM44	375316	broad.mit.edu	37	2	238726701	238726701	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:238726701C>T	uc002vxi.3	+	3	1274	c.1142C>T	c.(1141-1143)TCC>TTC	p.S381F		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	380							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TGTCAAACTTCCTGGACCTCT	0.378			NA											9	70					0	0	0.008291	0	0
HDAC4	9759	broad.mit.edu	37	2	240066294	240066294	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:240066294G>A	uc002vyk.3	-	8	1642	c.850C>T	c.(850-852)CCG>TCG	p.P284S	HDAC4_uc010fyz.1_Missense_Mutation_p.P279S|HDAC4_uc010zoa.1_Missense_Mutation_p.P279S|HDAC4_uc010fza.2_Missense_Mutation_p.P284S|HDAC4_uc010fyy.2_Missense_Mutation_p.P236S|HDAC4_uc010znz.1_Missense_Mutation_p.P167S|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	284	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ACATCCAACGGACGCTTTTTT	0.577			NA											12	39					0	0	0.003163	0	0
OR6B2	389090	broad.mit.edu	37	2	240969840	240969840	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:240969840C>G	uc002vyr.2	-	2	53	c.7G>C	c.(7-9)GGG>CGG	p.G3R	OR6B2_uc010zoc.1_Missense_Mutation_p.G3R	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		ACATTCTCCCCACTCATGCCT	0.592			NA											10	27					0	0	0.006214	0	0
VPS16	64601	broad.mit.edu	37	20	2840774	2840774	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:2840774G>T	uc002whe.2	+	3	265	c.217G>T	c.(217-219)GGC>TGC	p.G73C	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.G73C|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	73					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						CTCTGCTTCCGGCATGCCTCT	0.577			NA											14	27					9.16793e-09	1.08926e-08	0.00499	1	0
RASSF2	9770	broad.mit.edu	37	20	4770300	4770300	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:4770300C>A	uc002wld.2	-	7	635	c.581G>T	c.(580-582)CGC>CTC	p.R194L	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.R194L|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	194	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding	p.R194H(1)		ovary(3)|lung(2)|large_intestine(1)	6						GCTGTTGATGCGGACGTTGGT	0.547	Melanoma(158;1891 3343 50738)		NA											12	60					6.31663e-08	7.35918e-08	0.003163	1	0
PLCB1	23236	broad.mit.edu	37	20	8770893	8770894	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:8770893_8770894GG>TT	uc002wnb.2	+	31	3411_3412	c.3408_3409GG>TT	c.(3406-3411)CTGGAT>CTTTAT	p.D1137Y	PLCB1_uc002wna.2_Missense_Mutation_p.D1137Y	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1137					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGCAGATCCTGGATGAAAAGCC	0.342			NA											29	106					0	0	0.004672	0	0
C20orf114	92747	broad.mit.edu	37	20	31873972	31873972	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:31873972C>T	uc002wyw.1	+	2	254	c.93C>T	c.(91-93)CTC>CTT	p.L31L	C20orf114_uc010gej.1_Silent_p.L31L	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	31						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						TTCTCATCCTCGGCCCAAAAG	0.567			NA											8	44					0	0	0.00308	0	0
FAM83C	128876	broad.mit.edu	37	20	33876672	33876672	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:33876672G>T	uc010zux.1	-	2	721	c.603C>A	c.(601-603)TAC>TAA	p.Y201*	FAM83C_uc002xcb.1_Nonsense_Mutation_p.Y25*	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	201										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CAAGGAGCAGGTACACAGGGA	0.602			NA											15	62					2.4624e-09	2.95816e-09	0.008871	1	0
SAMHD1	25939	broad.mit.edu	37	20	35540928	35540928	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:35540928G>A	uc002xgh.1	-	10	1220	c.1090C>T	c.(1090-1092)CAC>TAC	p.H364Y		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	364					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TTGCGAGTGTGGAACATGTCA	0.328			NA											39	113					0	0	0.00361	0	0
LBP	3929	broad.mit.edu	37	20	36993349	36993349	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:36993349G>T	uc002xic.1	+	8	899	c.864G>T	c.(862-864)ACG>ACT	p.T288T		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	288					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TCTTCAACACGGCCAGCCTGG	0.473			NA											41	227					1.02687e-29	1.61429e-29	0.003214	1	0
LBP	3929	broad.mit.edu	37	20	36993396	36993396	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:36993396C>A	uc002xic.1	+	8	946	c.911C>A	c.(910-912)ACA>AAA	p.T304K		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	304					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TTCTCCATCACAGATGACATG	0.453			NA											27	199					2.81731e-10	3.44197e-10	0.002096	1	0
CHD6	84181	broad.mit.edu	37	20	40081428	40081428	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:40081428T>A	uc002xka.1	-	21	3453	c.3275A>T	c.(3274-3276)TAC>TTC	p.Y1092F		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1092					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CGCTCGGAGGTAGCGCCTGGC	0.517			NA											5	170					0	0	0.001168	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505620	44505620	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:44505620C>T	uc002xqd.2	+	2	626	c.423C>T	c.(421-423)GCC>GCT	p.A141A	ZSWIM3_uc010zxg.1_Silent_p.A135A	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	141							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				TTGACACTGCCGAGAAGTCCC	0.517			NA											6	78					0	0	0.001168	0	0
MMP9	4318	broad.mit.edu	37	20	44637627	44637627	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:44637627C>T	uc002xqz.2	+	1	81	c.62C>T	c.(61-63)CCC>CTC	p.P21L		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	21					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTTGCTGCCCCCAGACAGCGC	0.617			NA											6	14					0	0	0.001168	0	0
BCAS1	8537	broad.mit.edu	37	20	52591957	52591957	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:52591957C>G	uc002xws.2	-	8	1491	c.1153G>C	c.(1153-1155)GAC>CAC	p.D385H	BCAS1_uc010zza.1_Intron|BCAS1_uc010zzb.1_Missense_Mutation_p.D333H|BCAS1_uc010gim.2_Intron|BCAS1_uc002xwt.2_Intron|BCAS1_uc010gil.1_Missense_Mutation_p.D385H	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	385						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GGGACTGAGTCCTCTTTAACT	0.403			NA											14	118					0	0	0.006122	0	0
BCAS1	8537	broad.mit.edu	37	20	52612502	52612502	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:52612502C>A	uc002xws.2	-	5	1149	c.811G>T	c.(811-813)GCA>TCA	p.A271S	BCAS1_uc010zza.1_5'UTR|BCAS1_uc010zzb.1_Missense_Mutation_p.A174S|BCAS1_uc010gim.2_Missense_Mutation_p.A174S|BCAS1_uc002xwt.2_Missense_Mutation_p.A271S|BCAS1_uc010gil.1_Missense_Mutation_p.A271S	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	271						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TCGTCCTTTGCAGTCTCCAGT	0.473			NA											73	207					1.62783e-20	2.34407e-20	0.00361	1	0
ZNF831	128611	broad.mit.edu	37	20	57829002	57829002	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:57829002C>G	uc002yan.2	+	5	4238	c.4238C>G	c.(4237-4239)ACT>AGT	p.T1413S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1413						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ACTCACAGCACTGCTGCCACA	0.498			NA											29	218					0	0	0.003271	0	0
EDN3	1908	broad.mit.edu	37	20	57876663	57876663	+	Missense_Mutation	SNP	C	C	A	rs142051051	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:57876663C>A	uc002yap.2	+	2	620	c.251C>A	c.(250-252)GCG>GAG	p.A84E	EDN3_uc002yao.1_Missense_Mutation_p.A84E|EDN3_uc002yaq.2_Missense_Mutation_p.A84E|EDN3_uc002yar.2_Missense_Mutation_p.A84E|EDN3_uc002yas.2_Missense_Mutation_p.A84E	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	84					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					CAGGAGCAGGCGGCCGAGGGG	0.662			NA											7	19					8.12818e-05	8.93935e-05	0.001984	1	0
PHACTR3	116154	broad.mit.edu	37	20	58348406	58348406	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:58348406C>T	uc002yau.2	+	6	1291	c.824C>T	c.(823-825)CCC>CTC	p.P275L	PHACTR3_uc002yat.2_Missense_Mutation_p.P272L|PHACTR3_uc010zzw.1_Missense_Mutation_p.P234L|PHACTR3_uc002yav.2_Missense_Mutation_p.P234L|PHACTR3_uc002yaw.2_Missense_Mutation_p.P234L|PHACTR3_uc002yax.2_Missense_Mutation_p.P164L	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	275						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTCTCCACACCCACGGGGTCT	0.662			NA											4	45					0	0	0.004482	0	0
SLC17A9	63910	broad.mit.edu	37	20	61588903	61588903	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:61588903T>C	uc002yea.3	+	3	552	c.368T>C	c.(367-369)TTC>TCC	p.F123S	SLC17A9_uc002ydz.3_Missense_Mutation_p.F117S|SLC17A9_uc011aap.1_Missense_Mutation_p.F143S	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	123	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TTCATGACCTTCTCACGCATC	0.612			NA											3	30					0	0	0.004672	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31691975	31691975	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:31691975G>T	uc002ynw.2	-	1	633	c.379C>A	c.(379-381)CCG>ACG	p.P127T		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	127						intermediate filament				ovary(1)	1						TTGAGCAGCGGCCTCAGTGGA	0.537			NA											15	351					8.60227e-14	1.12475e-13	0.004007	1	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768708	31768708	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:31768708T>G	uc002yoa.2	+	1	317	c.304T>G	c.(304-306)TTT>GTT	p.F102V		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	102						intermediate filament				ovary(1)	1						GTCTCTAGGCTTTGGATCCAG	0.597			NA											5	67					0	0	0.001984	0	0
CLDN14	23562	broad.mit.edu	37	21	37833580	37833580	+	Missense_Mutation	SNP	C	C	A	rs142846225	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:37833580C>A	uc002yvk.1	-	2	556	c.414G>T	c.(412-414)TGG>TGT	p.W138C	CLDN14_uc002yvn.1_Missense_Mutation_p.W138C|CLDN14_uc002yvo.1_Missense_Mutation_p.W138C|CLDN14_uc002yvl.1_Missense_Mutation_p.W138C|CLDN14_uc002yvm.1_Missense_Mutation_p.W138C	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	138	Extracellular (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CGTTGGTGGTCCAGGAGACGG	0.637			NA											10	37					1.61879e-10	1.98219e-10	0.001368	1	0
ERG	2078	broad.mit.edu	37	21	39775598	39775598	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:39775598T>G	uc010gnw.2	-	6	738	c.443A>C	c.(442-444)CAG>CCG	p.Q148P	ERG_uc002yxa.2_Missense_Mutation_p.Q141P|ERG_uc011aek.1_Missense_Mutation_p.Q49P|ERG_uc010gnv.2_Missense_Mutation_p.Q49P|ERG_uc010gnx.2_Missense_Mutation_p.Q148P|ERG_uc011ael.1_Missense_Mutation_p.Q148P|ERG_uc002yxb.2_Missense_Mutation_p.Q148P|ERG_uc011aem.1_Intron|ERG_uc002yxc.3_Missense_Mutation_p.Q148P|ERG_uc010gny.1_RNA	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	148	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CTCCAGCCACTGCCGCACATG	0.507	Esophageal Squamous(130;336 1700 3010 3083 40589)		NA											57	183					0	0	0.00361	0	0
IGSF5	150084	broad.mit.edu	37	21	41137527	41137527	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:41137527G>T	uc002yyo.2	+	3	269	c.166G>T	c.(166-168)GCT>TCT	p.A56S		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	56	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				GGGCTCCCAGGCTCGCTTCAA	0.527			NA											65	138					1.25089e-41	2.10758e-41	0.00361	1	0
DSCAM	1826	broad.mit.edu	37	21	41725556	41725556	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:41725556C>T	uc002yyq.1	-	5	1222	c.770G>A	c.(769-771)CGC>CAC	p.R257H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	257	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTCAGCCAGCGGTAATCTGG	0.602	Melanoma(134;970 1778 1785 21664 32388)		NA											4	67					0	0	0.001984	0	0
MX2	4600	broad.mit.edu	37	21	42771258	42771258	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:42771258C>T	uc002yzf.1	+	10	1512	c.1408C>T	c.(1408-1410)CAA>TAA	p.Q470*	MX2_uc002yzg.1_Nonsense_Mutation_p.Q193*|MX2_uc010gop.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	470					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AACTAATACCCAAAAAGGTAA	0.443			NA											10	109					0	0	0.001855	0	0
ZNF295	49854	broad.mit.edu	37	21	43412161	43412161	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:43412161G>T	uc002zab.3	-	3	2258	c.2044C>A	c.(2044-2046)CTC>ATC	p.L682I	ZNF295_uc002yzz.3_Intron|ZNF295_uc002yzy.3_Missense_Mutation_p.L682I|ZNF295_uc002zaa.3_Missense_Mutation_p.L682I	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	682	C2H2-type 3.				negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AATTGAGAGAGAAAGCGGTAC	0.433			NA											8	101					0.00448238	0.00470454	0.004482	1	0
UMODL1	89766	broad.mit.edu	37	21	43524089	43524089	+	Missense_Mutation	SNP	G	G	T	rs150059583		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:43524089G>T	uc002zaf.1	+	9	1411	c.1411G>T	c.(1411-1413)GTG>TTG	p.V471L	UMODL1_uc002zad.1_Missense_Mutation_p.V399L|UMODL1_uc002zae.1_Missense_Mutation_p.V399L|UMODL1_uc002zag.1_Missense_Mutation_p.V471L|UMODL1_uc010gow.1_Missense_Mutation_p.V263L|UMODL1_uc002zai.1_Missense_Mutation_p.V122L|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.V122L|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.V216L|C21orf128_uc002zak.2_Missense_Mutation_p.H48Q	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	471	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CAAGCTCACCGTGCAGGACCC	0.607	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											17	71					7.21436e-19	1.02251e-18	0.008871	1	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032564	46032564	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:46032564G>T	uc002zfo.1	+	1	569	c.547G>T	c.(547-549)GCT>TCT	p.A183S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	183	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						CTGCTCTGGGGCTTCCTCTCT	0.587			NA											93	338					1.8585e-67	3.44876e-67	0.00361	1	0
CCT8L2	150160	broad.mit.edu	37	22	17071902	17071902	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:17071902C>G	uc002zlp.1	-	1	1799	c.1539G>C	c.(1537-1539)CAG>CAC	p.Q513H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	513					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAGTCACGAGCTGTAGCACCA	0.498			NA											41	77					0	0	0.00361	0	0
MICAL3	57553	broad.mit.edu	37	22	18301457	18301457	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:18301457C>A	uc002zng.3	-	26	4323	c.3970G>T	c.(3970-3972)GTG>TTG	p.V1324L	MICAL3_uc011agl.1_Missense_Mutation_p.V1240L	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1324	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AACTCCTCCACCAGGTCGCTC	0.662			NA											3	9					0.00024832	0.000270348	0.009096	1	0
SEZ6L	23544	broad.mit.edu	37	22	26761403	26761403	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:26761403C>A	uc003acb.2	+	13	2821	c.2665C>A	c.(2665-2667)CGA>AGA	p.R889R	SEZ6L_uc003acc.2_Silent_p.R889R|SEZ6L_uc011akc.1_Silent_p.R889R|SEZ6L_uc003acd.2_Silent_p.R825R|SEZ6L_uc011akd.1_Silent_p.R889R|SEZ6L_uc003ace.2_Intron|SEZ6L_uc003acf.1_Silent_p.R662R|SEZ6L_uc010gvc.1_Intron|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	889	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CCTGTACAAGCGACTCTACCT	0.547			NA											65	112					4.81439e-37	7.92614e-37	0.00361	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091841	+	Missense_Mutation	DNP	TG	TG	CA	rs142470496	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:29091840_29091841TG>CA	uc003adu.1	-	11	1188_1189	c.1116_1117CA>TG	c.(1114-1119)TCCAAG>TCTGAG	p.K373E	CHEK2_uc003ads.1_Missense_Mutation_p.K152E|CHEK2_uc010gvh.1_Missense_Mutation_p.K282E|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.K416E|CHEK2_uc003adv.1_Missense_Mutation_p.K344E|CHEK2_uc003adw.1_Missense_Mutation_p.K373E|CHEK2_uc003adx.1_Missense_Mutation_p.K152E|CHEK2_uc003ady.1_Missense_Mutation_p.K373E|CHEK2_uc003adz.1_Missense_Mutation_p.K177E	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	373	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(2)|p.S372S(1)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCCAAAATCTTGGAGTGCCCAA	0.416			NA	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				6	89					0	0	0.004672	0	0
C22orf42	150297	broad.mit.edu	37	22	32550243	32550243	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:32550243G>T	uc003amd.2	-	2	336	c.295C>A	c.(295-297)CTA>ATA	p.L99I		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	99										ovary(1)|skin(1)	2						ATATTTTCTAGAGGCCAAATC	0.378			NA											23	76					3.93418e-24	5.90948e-24	0.004289	1	0
RANGAP1	5905	broad.mit.edu	37	22	41657531	41657531	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:41657531C>A	uc003azs.2	-	5	2004	c.534G>T	c.(532-534)AAG>AAT	p.K178N	RANGAP1_uc003azt.2_Missense_Mutation_p.K178N|RANGAP1_uc003azu.2_Missense_Mutation_p.K178N|RANGAP1_uc011aoz.1_Intron	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	178					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						GGGCCAGAGGCTTGCCTTGGG	0.582			NA											9	24					0.00244969	0.00258619	0.00245	1	0
C22orf9	23313	broad.mit.edu	37	22	45598869	45598869	+	Splice_Site	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:45598869A>C	uc003bfx.1	-	7	918	c.852_splice	c.e7+1	p.R284_splice	C22orf9_uc010gzw.1_Splice_Site_p.R136_splice|C22orf9_uc003bfv.1_Splice_Site_p.R293_splice|C22orf9_uc003bfw.1_Splice_Site_p.R289_splice|C22orf9_uc010gzx.2_Splice_Site_p.R266_splice|MIR1249_hsa-mir-1249|MI0006384_5'Flank	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b								protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		TGCAGCCCTTACCCGCTCGTG	0.652			NA											12	12					0	0	0.001855	0	0
SMC1B	27127	broad.mit.edu	37	22	45802673	45802673	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:45802673T>A	uc003bgc.2	-	3	424	c.372A>T	c.(370-372)ATA>ATT	p.I124I	SMC1B_uc003bgd.2_Silent_p.I124I|SMC1B_uc003bge.1_5'UTR	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	124					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTATTATGCCTATCTTTTCCA	0.299			NA											28	90					0	0	0.007835	0	0
ZBED4	9889	broad.mit.edu	37	22	50277734	50277734	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:50277734G>A	uc003bix.2	+	2	894	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	142	BED-type 1.					cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CTGTGTGAAGGAGTTCAGCAG	0.507			NA											31	69					0	0	0.003755	0	0
SHANK3	85358	broad.mit.edu	37	22	51143400	51143400	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:51143400G>T	uc003bne.1	+	17	1953	c.1953G>T	c.(1951-1953)GGG>GGT	p.G651G	SHANK3_uc003bnf.1_Silent_p.G106G	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	651										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		AGGTGAACGGGGTGAACGTGG	0.632			NA											6	26					0.00621372	0.00647137	0.006214	1	0
CNTN6	27255	broad.mit.edu	37	3	1415642	1415642	+	Silent	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:1415642A>C	uc003boz.2	+	16	2247	c.1980A>C	c.(1978-1980)GCA>GCC	p.A660A	CNTN6_uc011asj.1_Silent_p.A588A|CNTN6_uc003bpa.2_Silent_p.A660A	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	660	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CATACAATGCAACAGTGGTTG	0.388			NA											45	122					0	0	0.00361	0	0
CNTN4	152330	broad.mit.edu	37	3	2908612	2908612	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:2908612C>A	uc003bpc.2	+	7	852	c.631C>A	c.(631-633)CCA>ACA	p.P211T	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.P211T	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	211					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GCCACCTACACCACTAATATT	0.383			NA											21	67					4.26978e-12	5.41239e-12	0.00333	1	0
SEC13	6396	broad.mit.edu	37	3	10354321	10354321	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:10354321C>G	uc003bvn.2	-	4	377	c.258G>C	c.(256-258)TGG>TGC	p.W86C	SEC13_uc003bvl.2_Missense_Mutation_p.W18C|SEC13_uc003bvm.2_Missense_Mutation_p.W72C|SEC13_uc003bvp.2_Missense_Mutation_p.W89C|SEC13_uc003bvo.2_Missense_Mutation_p.W132C|SEC13_uc003bvq.1_Missense_Mutation_p.W72C|SEC13_uc003bvr.1_Missense_Mutation_p.W72C|SEC13_uc011aul.1_Missense_Mutation_p.W86C	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	86	WD 2.				COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						TTTCCTCTCTCCAGATAATGA	0.582			NA											27	74					0	0	0.005443	0	0
OXSM	54995	broad.mit.edu	37	3	25835674	25835674	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:25835674G>T	uc003cdn.2	+	3	1176	c.1069G>T	c.(1069-1071)GCT>TCT	p.A357S	OXSM_uc011awp.1_Missense_Mutation_p.A82S|OXSM_uc010hfh.2_Missense_Mutation_p.A274S	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	357					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						ATTGGGAGATGCTGCTGAAAA	0.453			NA											33	96					4.14481e-20	5.93686e-20	0.00623	1	0
TRANK1	9881	broad.mit.edu	37	3	36872739	36872739	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:36872739C>T	uc003cgj.2	-	12	6855	c.6553G>A	c.(6553-6555)GGC>AGC	p.G2185S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2735					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTCTCTGGGCCACGGGTAAAC	0.592			NA											37	131					0	0	0.007835	0	0
SLC22A13	9390	broad.mit.edu	37	3	38316550	38316550	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:38316550G>T	uc003chz.3	+	4	762	c.708G>T	c.(706-708)GGG>GGT	p.G236G	SLC22A13_uc011aym.1_RNA|SLC22A13_uc011ayn.1_Silent_p.G236G	NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	236	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TCTCCCTCGGGCAGATGGTGC	0.607			NA											46	126					9.57592e-29	1.49667e-28	0.00361	1	0
SCN11A	11280	broad.mit.edu	37	3	38936055	38936055	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:38936055T>A	uc011ays.1	-	15	3003	c.2804A>T	c.(2803-2805)CAG>CTG	p.Q935L	SCN11A_uc010hhn.1_Missense_Mutation_p.Q51L	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	935					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGTGATGCGCTGTGCATTATC	0.488			NA											15	769					0	0	0.00499	0	0
ULK4	54986	broad.mit.edu	37	3	41860964	41860964	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:41860964G>T	uc003ckv.3	-	19	2000	c.1799C>A	c.(1798-1800)GCT>GAT	p.A600D	ULK4_uc003ckw.2_Missense_Mutation_p.A600D	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	600							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CAAGGGAACAGCCCAGCACTC	0.438			NA											29	338					3.90053e-15	5.18789e-15	0.002445	1	0
TGM4	7047	broad.mit.edu	37	3	44951851	44951851	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:44951851C>A	uc003coc.3	+	11	1670	c.1597C>A	c.(1597-1599)CAA>AAA	p.Q533K		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	533					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CTCGCAGATCCAAGGTCAAGG	0.498			NA											42	75					1.12205e-10	1.38019e-10	0.00361	1	0
FYCO1	79443	broad.mit.edu	37	3	46021226	46021226	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:46021226C>A	uc003cpb.3	-	4	465	c.259G>T	c.(259-261)GGG>TGG	p.G87W	FYCO1_uc011bal.1_Missense_Mutation_p.G87W	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	87	RUN.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		AAGCGGATCCCATCATTGGCT	0.507			NA											45	132					9.52127e-25	1.44424e-24	0.00361	1	0
RASSF1	11186	broad.mit.edu	37	3	50368057	50368057	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:50368057G>A	uc003dad.1	-	6	1121	c.990C>T	c.(988-990)TGC>TGT	p.C330C	TUSC2_uc003czy.1_5'Flank|TUSC2_uc003czz.1_5'Flank|RASSF1_uc003daa.1_Silent_p.C175C|RASSF1_uc003dab.1_Silent_p.C256C|RASSF1_uc003dac.2_Silent_p.C175C|RASSF1_uc003dae.1_Silent_p.C326C|RASSF1_uc010hlk.1_RNA|RASSF1_uc003daf.1_Silent_p.C175C	NM_170714	NP_733832	Q9NS23	RASF1_HUMAN	Ras association domain family 1 isoform D	330	SARAH.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCTTCTGGCGGCAATAGGAGT	0.612			NA											12	22					0	0	0.00499	0	0
ITIH1	3697	broad.mit.edu	37	3	52818397	52818397	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:52818397C>T	uc003dfs.2	+	11	1335	c.1311C>T	c.(1309-1311)CAC>CAT	p.H437H	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.H38H|ITIH1_uc010hmo.1_5'UTR	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	437	Hyaluronan-binding.|VWFA.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GTTTCGGCCACAATGTGGACT	0.577			NA											26	27					0	0	0.003954	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54872616	54872616	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:54872616G>T	uc003dhf.2	+	16	1540	c.1492G>T	c.(1492-1494)GGA>TGA	p.G498*	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Nonsense_Mutation_p.G404*|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Nonsense_Mutation_p.G232*	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	498	Extracellular (Potential).|Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CATTCTTCTGGGAGTGGTTGG	0.383			NA											5	214					0.00116845	0.00123961	0.001168	1	0
CADPS	8618	broad.mit.edu	37	3	62636588	62636588	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:62636588G>C	uc003dll.2	-	5	1497	c.1137C>G	c.(1135-1137)ATC>ATG	p.I379M	CADPS_uc003dlm.2_Missense_Mutation_p.I379M|CADPS_uc003dln.2_Missense_Mutation_p.I379M	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	379					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CGCCCATGTCGATGATGGAAG	0.522			NA											38	157					0	0	0.00874	0	0
CADPS	8618	broad.mit.edu	37	3	62751567	62751567	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:62751567G>T	uc003dll.2	-	2	894	c.534C>A	c.(532-534)AAC>AAA	p.N178K	CADPS_uc003dlm.2_Missense_Mutation_p.N178K|CADPS_uc003dln.2_Missense_Mutation_p.N178K	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	178					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCTGCACAGCGTTCATGAAGG	0.517			NA											71	335					2.13026e-44	3.66351e-44	0.00361	1	0
PDZRN3	23024	broad.mit.edu	37	3	73432940	73432940	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:73432940C>G	uc003dpl.1	-	10	2873	c.2777G>C	c.(2776-2778)CGC>CCC	p.R926P	PDZRN3_uc011bgh.1_Missense_Mutation_p.R583P|PDZRN3_uc010hoe.1_Missense_Mutation_p.R624P|PDZRN3_uc011bgf.1_Missense_Mutation_p.R643P|PDZRN3_uc011bgg.1_Missense_Mutation_p.R646P	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	926							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCCGTCGCTGCGGATCTTCAC	0.667			NA											6	25					0	0	0.001168	0	0
EPHA6	285220	broad.mit.edu	37	3	96706434	96706434	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:96706434C>A	uc010how.1	+	3	754	c.711C>A	c.(709-711)AAC>AAA	p.N237K	EPHA6_uc003drp.1_Missense_Mutation_p.N237K	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	142	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TCAAGCCAAACCAGTATACAA	0.413			NA											176	542					2.07866e-96	3.98748e-96	0.00361	1	0
OR5K3	403277	broad.mit.edu	37	3	98110266	98110266	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:98110266C>A	uc011bgw.1	+	1	757	c.757C>A	c.(757-759)CTT>ATT	p.L253I		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGTGATTCCCTTCTCTTCAT	0.353			NA											142	515					1.14095e-56	2.0401e-56	0.00361	1	0
OR5K1	26339	broad.mit.edu	37	3	98188534	98188534	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:98188534C>G	uc003dsm.2	+	1	114	c.114C>G	c.(112-114)ACC>ACG	p.T38T		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						ATCTGATCACCGTGGTGGGGA	0.433			NA											113	569					0	0	0.00361	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278693	108278693	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:108278693C>A	uc003dxb.3	-	16	2193	c.1924G>T	c.(1924-1926)GAT>TAT	p.D642Y		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	642	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TCCAAAAGATCTTGTAGCCTG	0.353			NA											16	91					6.94344e-10	8.41629e-10	0.006122	1	0
KIAA2018	205717	broad.mit.edu	37	3	113375768	113375768	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:113375768G>T	uc003eam.2	-	7	5172	c.4761C>A	c.(4759-4761)AAC>AAA	p.N1587K	KIAA2018_uc003eal.2_Missense_Mutation_p.N1531K	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1587	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GGTTATGATGGTTCCGACTAG	0.478			NA											24	92					1.37878e-21	2.02321e-21	0.00333	1	0
LSAMP	4045	broad.mit.edu	37	3	115805319	115805319	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:115805319C>A	uc003ebt.2	-	2	740	c.240G>T	c.(238-240)CTG>CTT	p.L80L	LSAMP_uc011bis.1_Silent_p.L80L	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	80	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CCCGTGGGTCCAGAGACCACT	0.502			NA											41	186					6.87076e-12	8.68902e-12	0.00361	1	0
RABL3	285282	broad.mit.edu	37	3	120417341	120417341	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:120417341T>A	uc003edx.2	-	5	493	c.463A>T	c.(463-465)ACA>TCA	p.T155S		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	155	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		TGGCGCTTTGTTTCATGAATC	0.358			NA											158	511					0	0	0.00361	0	0
POLQ	10721	broad.mit.edu	37	3	121209249	121209249	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:121209249C>A	uc003eee.3	-	16	2658	c.2529G>T	c.(2527-2529)CGG>CGT	p.R843R	POLQ_uc003eed.2_Silent_p.R15R	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	843					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCACTGCCTTCCGGGCACTAC	0.333	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					65	261					2.73218e-42	4.63227e-42	0.00361	1	0
FBXO40	51725	broad.mit.edu	37	3	121342078	121342078	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:121342078T>G	uc003eeg.2	+	3	2012	c.1802T>G	c.(1801-1803)GTG>GGG	p.V601G		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	601	F-box.				muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		CAGGTGTCTGTGCTGATGAGG	0.493			NA											5	242					0	0	0.001984	0	0
ADCY5	111	broad.mit.edu	37	3	123046503	123046503	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:123046503T>A	uc003egh.1	-	7	1909	c.1909A>T	c.(1909-1911)ATC>TTC	p.I637F	ADCY5_uc003egg.1_Missense_Mutation_p.I270F|ADCY5_uc003egi.1_Missense_Mutation_p.I196F	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	637	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AAGGTCTCGATACTGTGCTCC	0.622			NA											13	41					0	0	0.001855	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125850370	125850370	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:125850370C>A	uc003eim.1	-	13	1670	c.1480G>T	c.(1480-1482)GAT>TAT	p.D494Y	ALDH1L1_uc010hse.1_Intron|ALDH1L1_uc011bki.1_Missense_Mutation_p.D393Y|ALDH1L1_uc003eio.2_Missense_Mutation_p.D196Y	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	494	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCCATGAGATCTGCCAACCTG	0.647			NA											17	51					1.00905e-13	1.31298e-13	0.008871	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125872401	125872401	+	Silent	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:125872401C>G	uc003eim.1	-	7	934	c.744G>C	c.(742-744)ACG>ACC	p.T248T	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.T147T|ALDH1L1_uc003eio.2_5'UTR|ALDH1L1_uc010hsf.1_Silent_p.T274T|ALDH1L1_uc003eip.1_Silent_p.T155T|ALDH1L1_uc011bkj.1_Silent_p.T73T	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	248					10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	AAGTGTTCAGCGTTGAGTTGA	0.562			NA											13	70					0	0	0.003163	0	0
CHST13	166012	broad.mit.edu	37	3	126255153	126255153	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:126255153G>C	uc003eja.2	+	2	137	c.137G>C	c.(136-138)GGG>GCG	p.G46A		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	46	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		TGGCTTGGTGGGGAGAAGAGA	0.607			NA											7	29					0	0	0.001855	0	0
RUVBL1	8607	broad.mit.edu	37	3	127842427	127842427	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:127842427C>A	uc003ekh.2	-	1	245	c.141G>T	c.(139-141)GAG>GAT	p.E47D	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Missense_Mutation_p.E47D	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	47					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CTGGCCACACCTCTCGCGCGT	0.706			NA											12	26					0.000978159	0.00104699	0.000978	1	0
PLXND1	23129	broad.mit.edu	37	3	129279567	129279567	+	Splice_Site	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:129279567C>G	uc003emx.2	-	30	5094	c.4994_splice	c.e30-1	p.V1665_splice	PLXND1_uc003emw.2_5'Flank|PLXND1_uc011blb.1_Splice_Site_p.V333_splice	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor						axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AAGTCTTTCACTGTGAGAGGA	0.383	Ovarian(97;366 1484 3738 22084 39045)		NA											6	15					0	0	0.00308	0	0
SOX14	8403	broad.mit.edu	37	3	137483858	137483858	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:137483858C>A	uc003erm.1	+	1	280	c.232C>A	c.(232-234)CGA>AGA	p.R78R		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	78					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						CTACAAGTACCGACCTCGGCG	0.612			NA											11	88					6.53275e-17	9.01069e-17	0.00245	1	0
PAQR9	344838	broad.mit.edu	37	3	142681802	142681802	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:142681802G>T	uc003evg.2	-	1	377	c.377C>A	c.(376-378)GCG>GAG	p.A126E	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	126	Helical; (Potential).					integral to membrane	receptor activity				0						CACTCCCGACGCGTAGCACCA	0.652			NA											7	22					7.48243e-07	8.5877e-07	0.006214	1	0
IGSF10	285313	broad.mit.edu	37	3	151154859	151154859	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:151154859G>T	uc011bod.1	-	6	7490	c.7490C>A	c.(7489-7491)ACA>AAA	p.T2497K	IGSF10_uc011bob.1_Missense_Mutation_p.T524K|IGSF10_uc011boc.1_Missense_Mutation_p.T476K	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2497	Ig-like C2-type 11.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTCATAAGCTGTTGCTTCTTT	0.388			NA											131	293					2.77863e-71	5.2009e-71	0.00361	1	0
IGSF10	285313	broad.mit.edu	37	3	151164627	151164627	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:151164627C>A	uc011bod.1	-	4	3142	c.3142G>T	c.(3142-3144)GAA>TAA	p.E1048*		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1048					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCTTTTTTCAGAAGAACCT	0.493			NA											113	274					2.77834e-61	5.07717e-61	0.00361	1	0
AADACL2	344752	broad.mit.edu	37	3	151474962	151474962	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:151474962G>A	uc003ezc.2	+	5	906	c.786G>A	c.(784-786)TGG>TGA	p.W262*	AADACL2_uc010hvn.2_Nonsense_Mutation_p.W49*	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	262						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CACTTCCCTGGGCAATGAGAA	0.413			NA											117	295					0	0	0.00361	0	0
IFT80	57560	broad.mit.edu	37	3	159998598	159998598	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:159998598T>A	uc011boy.1	-	15	1954	c.1521A>T	c.(1519-1521)ACA>ACT	p.T507T	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.T370T|IFT80_uc003fdd.1_Silent_p.T190T|IFT80_uc003fde.1_Silent_p.T370T	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	507	WD 7.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TATGCACCATTGTTCCTTAAT	0.313			NA											19	37					0	0	0.001882	0	0
SMC4	10051	broad.mit.edu	37	3	160120494	160120494	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:160120494A>T	uc003fdh.2	+	4	462	c.349A>T	c.(349-351)AGT>TGT	p.S117C	IFT80_uc003fda.2_Intron|SMC4_uc003fdf.1_RNA|SMC4_uc003fdg.1_Missense_Mutation_p.S117C|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.S92C|SMC4_uc003fdj.2_Missense_Mutation_p.S117C|SMC4_uc010hwd.2_Missense_Mutation_p.S117C|uc011boz.1_5'Flank|MIR15B_hsa-mir-15b|MI0000438_5'Flank|uc003fdk.2_5'Flank|MIR16-2_hsa-mir-16-2|MI0000115_5'Flank	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	117	ATP (Potential).				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GCCAAATGGCAGTGGCAAATC	0.323			NA											30	32					0	0	0.005524	0	0
DCUN1D1	54165	broad.mit.edu	37	3	182681763	182681763	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:182681763T>C	uc003fld.1	-	3	344	c.295A>G	c.(295-297)AGC>GGC	p.S99G	DCUN1D1_uc011bqn.1_Intron	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	99	DCUN1.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ACACTAATGCTGGCTGGATCG	0.418			NA											19	148					0	0	0.00278	0	0
KLHL6	89857	broad.mit.edu	37	3	183209920	183209920	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:183209920G>C	uc003flr.2	-	7	1719	c.1661C>G	c.(1660-1662)GCG>GGG	p.A554G	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	554	Kelch 5.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTTGCAGGGCGCGATACCGCA	0.657			NA											17	39					0	0	0.00333	0	0
EIF4A2	1974	broad.mit.edu	37	3	186505350	186505350	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:186505350G>T	uc003fqs.2	+	9	1015	c.976G>T	c.(976-978)GTT>TTT	p.V326F	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Missense_Mutation_p.V327F|EIF4A2_uc003fqv.2_Missense_Mutation_p.V231F|EIF4A2_uc003fqw.2_Missense_Mutation_p.V231F|EIF4A2_uc011bsb.1_Missense_Mutation_p.V199F|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	326	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		GTCAAGTCGTGTTCTGATCAC	0.398			NA	T	BCL6	NHL								34	123					2.68985e-26	4.12062e-26	0.00361	1	0
GAK	2580	broad.mit.edu	37	4	905514	905514	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:905514T>A	uc003gbm.3	-	4	528	c.329A>T	c.(328-330)GAG>GTG	p.E110V	GAK_uc003gbn.3_Intron|GAK_uc010ibk.1_Intron|GAK_uc003gbo.2_RNA|GAK_uc003gbl.3_5'UTR	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	110	Protein kinase.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GTCTGACTCCTCTTTTCCTAT	0.507			NA											5	32					0	0	0.00308	0	0
CNO	55330	broad.mit.edu	37	4	6718442	6718442	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:6718442C>T	uc003gjp.1	+	1	601	c.506C>T	c.(505-507)GCG>GTG	p.A169V		NM_018366	NP_060836	Q9NUP1	CNO_HUMAN	cappuccino	169					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol					0				Colorectal(103;0.0523)		TTCCCCAGGGCGTTCAAGAAG	0.657			NA											3	26					0	0	0.009096	0	0
BOD1L	259282	broad.mit.edu	37	4	13605956	13605956	+	Silent	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:13605956A>G	uc003gmz.1	-	10	2685	c.2568T>C	c.(2566-2568)GGT>GGC	p.G856G	BOD1L_uc010idr.1_Silent_p.G193G	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	856	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GTTGCTTGGAACCCAGAGAAT	0.368			NA											3	82					0	0	0.000602	0	0
LGI2	55203	broad.mit.edu	37	4	25014018	25014018	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:25014018G>A	uc003grf.2	-	7	858	c.759C>T	c.(757-759)AAC>AAT	p.N253N		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	253	EAR 1.					extracellular region					0		Breast(46;0.173)				GCACCATGCAGTTCTCCATGC	0.468			NA											49	281					0	0	0.00361	0	0
RBM47	54502	broad.mit.edu	37	4	40440430	40440430	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:40440430T>A	uc003gvc.2	-	4	1191	c.481A>T	c.(481-483)ATG>TTG	p.M161L	RBM47_uc003gvd.2_Missense_Mutation_p.M161L|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.M123L|RBM47_uc003gvg.1_Missense_Mutation_p.M161L	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	161	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CGCTTCTTCATCTTGGGGATC	0.627			NA											9	23					0	0	0.006214	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750472	41750472	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:41750472C>A	uc003gwf.3	-	1	516	c.156G>T	c.(154-156)GGG>GGT	p.G52G		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	52					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CGGACGTGGCCCCAAAAGTGG	0.627			NA	Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				8	46					0.00307968	0.0032481	0.00308	1	0
PHOX2B	8929	broad.mit.edu	37	4	41750491	41750491	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:41750491G>T	uc003gwf.3	-	1	497	c.137C>A	c.(136-138)CCG>CAG	p.P46Q		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	46					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						GGTCCTTATCGGGTTATACTG	0.627			NA	Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	52					0.00116845	0.00123961	0.001168	1	0
YIPF7	285525	broad.mit.edu	37	4	44626769	44626769	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:44626769C>A	uc010ifx.1	-	5	546	c.529G>T	c.(529-531)GGC>TGC	p.G177C		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	177	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						GCACTCATGCCATACACATAA	0.478			NA											32	98					2.45108e-15	3.2681e-15	0.00874	1	0
GABRB1	2560	broad.mit.edu	37	4	47427876	47427876	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:47427876G>T	uc003gxh.2	+	9	1640	c.1266G>T	c.(1264-1266)GGG>GGT	p.G422G	GABRB1_uc011bze.1_Silent_p.G352G	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	422	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACCGGCACGGGGTACCCAGCA	0.627			NA											12	65					2.61681e-11	3.2597e-11	0.00245	1	0
TXK	7294	broad.mit.edu	37	4	48114498	48114498	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:48114498C>T	uc003gxx.3	-	4	292	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	TXK_uc003gxy.1_Missense_Mutation_p.R69Q	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	69	Nuclear localization signal (Potential).					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CAGTGGCTTTCGTTTTGACGG	0.433			NA											16	304					0	0	0.00278	0	0
LRRC66	339977	broad.mit.edu	37	4	52860545	52860545	+	Nonstop_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:52860545T>G	uc003gzi.2	-	4	2656	c.2643A>C	c.(2641-2643)TAA>TAC	p.*881Y		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	881						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TGAAAGATTCTTATTTTAAAA	0.383			NA											12	159					0	0	0.001368	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182405	57182405	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:57182405G>T	uc003hbk.2	+	8	3128	c.2737G>T	c.(2737-2739)GCC>TCC	p.A913S	KIAA1211_uc010iha.2_Missense_Mutation_p.A906S|KIAA1211_uc011bzz.1_Missense_Mutation_p.A823S|KIAA1211_uc003hbm.1_Missense_Mutation_p.A799S	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	913										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCGGAAGCAAGCCCCTTCCAC	0.687			NA											9	26					4.68919e-08	5.49276e-08	0.008291	1	0
EPHA5	2044	broad.mit.edu	37	4	66230783	66230783	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:66230783G>T	uc003hcy.2	-	12	2381	c.2188C>A	c.(2188-2190)CAG>AAG	p.Q730K	EPHA5_uc003hcx.2_Missense_Mutation_p.Q662K|EPHA5_uc003hcz.2_Missense_Mutation_p.Q708K|EPHA5_uc011cah.1_Missense_Mutation_p.Q731K|EPHA5_uc011cai.1_Missense_Mutation_p.Q709K|EPHA5_uc003hda.2_Missense_Mutation_p.Q731K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	730	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TGATCAAACTGTCCCATGATA	0.388			NA								TSP Lung(17;0.13)			140	582					9.97597e-95	1.90354e-94	0.00361	1	0
STAP1	26228	broad.mit.edu	37	4	68436840	68436840	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:68436840T>A	uc003hde.3	+	2	241	c.159T>A	c.(157-159)ACT>ACA	p.T53T	STAP1_uc003hdf.2_Silent_p.T53T	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	53	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						GAGGAACTACTCTTTTCTTTT	0.308			NA											142	369					0	0	0.00361	0	0
UGT2A3	79799	broad.mit.edu	37	4	69811061	69811061	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:69811061C>T	uc003hef.2	-	2	858	c.827G>A	c.(826-828)GGA>GAA	p.G276E	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	276	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GTGCAATCCTCCAACAAACTC	0.368			NA											46	210					0	0	0.00361	0	0
UGT2A1	10941	broad.mit.edu	37	4	70513291	70513291	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:70513291C>A	uc003hem.3	-	1	135	c.72G>T	c.(70-72)TTG>TTT	p.L24F	UGT2A1_uc011caq.1_Missense_Mutation_p.L24F|UGT2A1_uc010ihu.2_Missense_Mutation_p.L24F|UGT2A1_uc010iht.2_Missense_Mutation_p.L24F	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	24	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TTGGCCAAATCAAAACATTCC	0.398			NA											25	132					0.000147802	0.000162386	0.00632	1	0
CSN3	1448	broad.mit.edu	37	4	71114727	71114727	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:71114727G>C	uc003hfe.3	+	4	158	c.100G>C	c.(100-102)GAT>CAT	p.D34H		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	34						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCATGAGAATGATGAAAGACC	0.299			NA											31	157					0	0	0.003271	0	0
USO1	8615	broad.mit.edu	37	4	76703986	76703986	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:76703986T>A	uc003hiu.2	+	8	1005	c.830T>A	c.(829-831)GTG>GAG	p.V277E	USO1_uc003hiv.2_Missense_Mutation_p.V112E|USO1_uc003hiw.2_Missense_Mutation_p.V112E	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	277	ARM 5.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCACAGAAAGTGACCAATCTA	0.338			NA											5	130					0	0	0.001984	0	0
FRAS1	80144	broad.mit.edu	37	4	79367972	79367972	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:79367972T>A	uc003hlb.2	+	43	6388	c.5948T>A	c.(5947-5949)CTG>CAG	p.L1983Q		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1982	CSPG 8.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCTTTGAGCCTGCAAGACCTG	0.478			NA											5	48					0	0	0.000602	0	0
C4orf22	255119	broad.mit.edu	37	4	81866088	81866088	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:81866088C>A	uc003hmf.2	+	5	650	c.601C>A	c.(601-603)CCA>ACA	p.P201T	C4orf22_uc010ijp.2_Missense_Mutation_p.P218T	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	201										skin(2)	2						TAATGTGGACCCAAAGGTAAT	0.323			NA											24	96					1.88708e-17	2.6196e-17	0.008361	1	0
SEC31A	22872	broad.mit.edu	37	4	83740390	83740390	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:83740390G>T	uc003hnf.2	-	27	3664	c.3500C>A	c.(3499-3501)ACC>AAC	p.T1167N	SEC31A_uc003hnd.2_Missense_Mutation_p.T336N|SEC31A_uc003hne.2_Missense_Mutation_p.T916N|SEC31A_uc011ccl.1_Missense_Mutation_p.T1113N|SEC31A_uc003hnl.2_Missense_Mutation_p.T1014N|SEC31A_uc003hng.2_Missense_Mutation_p.T1152N|SEC31A_uc003hnh.2_Missense_Mutation_p.T1167N|SEC31A_uc003hni.2_Missense_Mutation_p.T1053N|SEC31A_uc003hnj.2_Missense_Mutation_p.T1128N|SEC31A_uc011ccm.1_Missense_Mutation_p.T1147N|SEC31A_uc011ccn.1_Missense_Mutation_p.T1152N|SEC31A_uc003hnk.2_Missense_Mutation_p.T1128N|SEC31A_uc003hnm.2_Missense_Mutation_p.T1167N	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1167					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TAAACCACTGGTGATTGTTGG	0.393			NA											59	304					2.01178e-46	3.48193e-46	0.00361	1	0
MEPE	56955	broad.mit.edu	37	4	88767150	88767150	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:88767150C>A	uc003hqy.2	+	4	1169	c.1130C>A	c.(1129-1131)GCA>GAA	p.A377E	MEPE_uc010ikn.2_Missense_Mutation_p.A264E	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	377					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TACCCTCCTGCACCCTCAAAA	0.438			NA											15	81					6.31663e-08	7.35918e-08	0.003163	1	0
MEPE	56955	broad.mit.edu	37	4	88767161	88767161	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:88767161G>C	uc003hqy.2	+	4	1180	c.1141G>C	c.(1141-1143)GAG>CAG	p.E381Q	MEPE_uc010ikn.2_Missense_Mutation_p.E268Q	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	381					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		ACCCTCAAAAGAGAAAAGAAA	0.443			NA											17	93					0	0	0.006122	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95210624	95210624	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:95210624G>T	uc003htc.3	+	24	3275	c.3020G>T	c.(3019-3021)GGT>GTT	p.G1007V	SMARCAD1_uc003htb.3_Missense_Mutation_p.G1009V|SMARCAD1_uc003htd.3_Missense_Mutation_p.G1009V|SMARCAD1_uc010ila.2_Missense_Mutation_p.G872V|SMARCAD1_uc011cdw.1_Missense_Mutation_p.G577V	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	1007	DEGD box.|Helicase C-terminal.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TGACCTACAGGTGATGAAGGG	0.269			NA											83	366					1.46924e-35	2.38614e-35	0.00361	1	0
C4orf37	285555	broad.mit.edu	37	4	98480220	98480220	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:98480220C>T	uc003htt.1	-	11	1459	c.1369G>A	c.(1369-1371)GAT>AAT	p.D457N		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	457											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		CACATTATATCAGCAGCCATT	0.284			NA											59	249					0	0	0.00361	0	0
C4orf37	285555	broad.mit.edu	37	4	98865110	98865110	+	Silent	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:98865110A>G	uc003htt.1	-	8	1072	c.982T>C	c.(982-984)TTG>CTG	p.L328L		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	328											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		TTGTTAGTCAAGTTAGGTAAT	0.318			NA											11	430					0	0	0.001855	0	0
AGXT2L1	64850	broad.mit.edu	37	4	109670480	109670480	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:109670480C>T	uc003hzc.2	-	8	1022	c.841G>A	c.(841-843)GGC>AGC	p.G281S	AGXT2L1_uc010imc.2_Missense_Mutation_p.G275S|AGXT2L1_uc011cfm.1_Missense_Mutation_p.G241S|AGXT2L1_uc011cfn.1_Missense_Mutation_p.G208S|AGXT2L1_uc011cfo.1_Missense_Mutation_p.G223S	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	281					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TGGCCGTTGCCCATCGGTTTT	0.468			NA											26	81					0	0	0.002096	0	0
COL25A1	84570	broad.mit.edu	37	4	109861765	109861765	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:109861765C>A	uc003hze.1	-	9	1133	c.602G>T	c.(601-603)GGC>GTC	p.G201V	COL25A1_uc003hzg.2_Missense_Mutation_p.G201V|COL25A1_uc003hzd.2_Intron|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	201	Extracellular (Potential).|Collagen-like 2.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GCCTGGAGGGCCAGGGGGTCC	0.562			NA											5	67					0.000157383	0.000172213	0.00308	1	0
NDST4	64579	broad.mit.edu	37	4	115773883	115773883	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:115773883G>C	uc003ibu.2	-	8	2493	c.1814C>G	c.(1813-1815)ACA>AGA	p.T605R	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	605	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.|PAPS (By similarity).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTTTTACCTGTTTTTTGTGG	0.303			NA											24	71					0	0	0.003954	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006108	118006108	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:118006108C>A	uc003ibv.3	-	1	629	c.442G>T	c.(442-444)GAC>TAC	p.D148Y		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	148	Lumenal (Potential).|TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						AGAGTTGGGTCTGACAGGCAG	0.383			NA											32	184					2.38352e-08	2.81334e-08	0.004289	1	0
SYNPO2	171024	broad.mit.edu	37	4	119948371	119948371	+	Missense_Mutation	SNP	C	C	T	rs35676119		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:119948371C>T	uc003icm.3	+	3	1043	c.847C>T	c.(847-849)CGG>TGG	p.R283W	SYNPO2_uc010ina.2_Missense_Mutation_p.R283W|SYNPO2_uc010inb.2_Missense_Mutation_p.R283W|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.R211W	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	283						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						GGGACTGCCCCGGGTGGAAGT	0.557			NA											28	65					0	0	0.002445	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951975	119951975	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:119951975G>T	uc003icm.3	+	4	2241	c.2045G>T	c.(2044-2046)GGA>GTA	p.G682V	SYNPO2_uc010ina.2_Missense_Mutation_p.G682V|SYNPO2_uc010inb.2_Missense_Mutation_p.G682V|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.G610V	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	682						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AAAAGAACAGGAATATTGCAG	0.498			NA											9	113					7.48243e-07	8.5877e-07	0.006214	1	0
PRDM5	11107	broad.mit.edu	37	4	121631535	121631535	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:121631535C>T	uc003idn.2	-	15	1907	c.1657G>A	c.(1657-1659)GCC>ACC	p.A553T	PRDM5_uc003ido.2_Missense_Mutation_p.A522T|PRDM5_uc010ine.2_Missense_Mutation_p.G493D	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	553	C2H2-type 14.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						TGGCTGAAGGCCTTGCTGCAC	0.483			NA											60	208					0	0	0.00361	0	0
KIAA1109	84162	broad.mit.edu	37	4	123260563	123260563	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:123260563G>T	uc003ieh.2	+	70	12397	c.12352G>T	c.(12352-12354)GGT>TGT	p.G4118C	KIAA1109_uc003iem.2_Missense_Mutation_p.G474C|KIAA1109_uc003ien.2_Missense_Mutation_p.G52C	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4118	Ser-rich.				regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGGAATACCAGGTATAGATAA	0.299			NA											15	45					4.14922e-12	5.27816e-12	0.004007	1	0
INTU	27152	broad.mit.edu	37	4	128632153	128632153	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:128632153G>T	uc003ifk.1	+	14	2525	c.2455G>T	c.(2455-2457)GAG>TAG	p.E819*	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	819										ovary(1)	1						TACCCTTGAAGAGGTGGCACA	0.418			NA											47	172					2.74695e-27	4.23211e-27	0.00361	1	0
PCDH10	57575	broad.mit.edu	37	4	134084177	134084177	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:134084177G>T	uc003iha.2	+	4	3669	c.2843G>T	c.(2842-2844)GGC>GTC	p.G948V		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	948	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AAAGCTCTGGGCCACTCAGAT	0.483			NA											28	126					6.28921e-32	1.00182e-31	0.003271	1	0
ELF2	1998	broad.mit.edu	37	4	139980627	139980627	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:139980627G>C	uc003ihp.1	-	9	1462	c.1256C>G	c.(1255-1257)CCA>CGA	p.P419R	ELF2_uc003ihm.1_Missense_Mutation_p.P371R|ELF2_uc003ihn.1_Missense_Mutation_p.P359R|ELF2_uc003iho.1_Missense_Mutation_p.P342R|ELF2_uc011chc.1_Missense_Mutation_p.P234R	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	431					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					GACTACCTTTGGAGAGGTCGC	0.438			NA											9	326					0	0	0.006214	0	0
ELF2	1998	broad.mit.edu	37	4	139988852	139988852	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:139988852G>C	uc003ihp.1	-	6	769	c.563C>G	c.(562-564)CCA>CGA	p.P188R	ELF2_uc003ihm.1_Missense_Mutation_p.P140R|ELF2_uc003ihn.1_Missense_Mutation_p.P128R|ELF2_uc003iho.1_Intron|ELF2_uc010ioh.2_Missense_Mutation_p.P128R	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	200					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					TCCTTCTCTTGGTTTCTTCTT	0.358			NA											33	103					0	0	0.006999	0	0
SLC10A7	84068	broad.mit.edu	37	4	147425062	147425062	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:147425062C>A	uc010ioz.2	-	4	589	c.335G>T	c.(334-336)GGT>GTT	p.G112V	SLC10A7_uc003ikr.2_Missense_Mutation_p.G112V|SLC10A7_uc010ipa.2_Missense_Mutation_p.G112V|SLC10A7_uc003iks.2_RNA|SLC10A7_uc003ikt.2_Missense_Mutation_p.G112V	NM_001029998	NP_001025169	Q0GE19	NTCP7_HUMAN	solute carrier family 10 (sodium/bile acid	112						integral to membrane	bile acid:sodium symporter activity				0	all_hematologic(180;0.151)					AGGCATGCAACCTACTGTCTG	0.373			NA											19	108					1.87028e-06	2.12846e-06	0.001882	1	0
TIGD4	201798	broad.mit.edu	37	4	153691700	153691700	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:153691700C>A	uc003imy.2	-	2	1239	c.457G>T	c.(457-459)GGT>TGT	p.G153C		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	153					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ACTGGTACACCTGTAGCTTCT	0.363			NA											16	42					0.00121646	0.00128928	0.008871	1	0
ARFIP1	27236	broad.mit.edu	37	4	153802270	153802270	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:153802270G>T	uc003imz.2	+	6	843	c.567G>T	c.(565-567)ATG>ATT	p.M189I	ARFIP1_uc003inb.2_Missense_Mutation_p.M157I|ARFIP1_uc003ina.2_Missense_Mutation_p.M157I|ARFIP1_uc003inc.2_Missense_Mutation_p.M189I|ARFIP1_uc011cij.1_Intron	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	189	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					TTTTCCAGATGGTACATACCC	0.348			NA											40	137					4.54978e-40	7.63007e-40	0.00361	1	0
FHDC1	85462	broad.mit.edu	37	4	153889217	153889217	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:153889217G>A	uc003inf.2	+	9	1261	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	396	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GCGGGATGGTGAACTTTGTCA	0.453			NA											29	93					0	0	0.009535	0	0
DCHS2	54798	broad.mit.edu	37	4	155298498	155298498	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:155298498G>T	uc003inw.2	-	3	333	c.333C>A	c.(331-333)ATC>ATA	p.I111I	DCHS2_uc003inx.2_Silent_p.I717I	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	111	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CATGAGGGTCGATCCGGAATG	0.463			NA											158	506					3.24732e-118	6.25152e-118	0.00361	1	0
FGB	2244	broad.mit.edu	37	4	155490753	155490753	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:155490753G>A	uc003ioa.3	+	7	1085	c.1046G>A	c.(1045-1047)GGA>GAA	p.G349E	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.G287E|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.G130E	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	349	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GACTGGAAAGGAGACAAAGTA	0.413	NSCLC(106;1133 1613 21870 46110 52656)		NA											15	283					0	0	0.006122	0	0
LRAT	9227	broad.mit.edu	37	4	155670250	155670250	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:155670250G>T	uc003iom.1	+	2	982	c.655G>T	c.(655-657)GCA>TCA	p.A219S	LRAT_uc003ion.1_Missense_Mutation_p.A219S	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	219	Lumenal (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	TACCCTTCCTGCAATTTTTAT	0.393			NA											30	153					7.83172e-31	1.24203e-30	0.004289	1	0
NPY2R	4887	broad.mit.edu	37	4	156135962	156135962	+	Missense_Mutation	SNP	G	G	T	rs147783618		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:156135962G>T	uc003ioq.2	+	2	1366	c.871G>T	c.(871-873)GTT>TTT	p.V291F	NPY2R_uc003ior.2_Missense_Mutation_p.V291F	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	291	Extracellular (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CCAGCTTGCCGTTGACATTGA	0.527			NA											14	85					9.05144e-12	1.14067e-11	0.001855	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160273941	160273941	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:160273941G>T	uc003iqg.3	+	21	3797	c.3487G>T	c.(3487-3489)GTG>TTG	p.V1163L		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1163	Ser-rich.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TTTTGACTCAGTGCCAGTCTC	0.478			NA											33	149					2.48696e-23	3.69452e-23	0.003271	1	0
NPY1R	4886	broad.mit.edu	37	4	164247270	164247270	+	Missense_Mutation	SNP	C	C	T	rs148479836		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:164247270C>T	uc003iqm.1	-	2	703	c.437G>A	c.(436-438)CGA>CAA	p.R146Q	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	146	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTCCACCCTCGAGGGTTGAT	0.423			NA											7	276					0	0	0.001984	0	0
TKTL2	84076	broad.mit.edu	37	4	164393898	164393898	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:164393898G>T	uc003iqp.3	-	1	1150	c.989C>A	c.(988-990)GCT>GAT	p.A330D		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	330						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				gcccagtttagccagagccaa	0.199			NA											43	195					1.32667e-27	2.04979e-27	0.00361	1	0
ANP32C	23520	broad.mit.edu	37	4	165118379	165118379	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:165118379C>A	uc011cjk.1	-	1	485	c.485G>T	c.(484-486)GGC>GTC	p.G162V	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	162	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GTCATCCAGGCCCTCCACGTG	0.418			NA											19	73					2.32416e-17	3.2222e-17	0.002299	1	0
Unknown	0	broad.mit.edu	37	4	165981615	165981615	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:165981615C>A	uc011cjl.1	+	1	1316	c.1316C>A	c.(1315-1317)ACT>AAT	p.T439N		NM_001105575	NP_001099045			tripartite motif-containing 75												NA						TGTACTTTCACTGACACTTTT	0.443			NA											33	41					1.06647e-15	1.4308e-15	0.003755	1	0
TLL1	7092	broad.mit.edu	37	4	166981296	166981296	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:166981296A>T	uc003irh.1	+	15	2610	c.1963A>T	c.(1963-1965)AGA>TGA	p.R655*	TLL1_uc011cjn.1_Nonsense_Mutation_p.R678*|TLL1_uc011cjo.1_Nonsense_Mutation_p.R479*	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	655	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AACCCAGTACAGAATTTCTGT	0.418			NA											29	96					0	0	0.005524	0	0
ACSL1	2180	broad.mit.edu	37	4	185697670	185697670	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:185697670C>A	uc003iww.2	-	7	1018	c.724G>T	c.(724-726)GGG>TGG	p.G242W	ACSL1_uc011ckm.1_Missense_Mutation_p.G71W|ACSL1_uc003iwt.1_Missense_Mutation_p.G242W|ACSL1_uc003iwu.1_Missense_Mutation_p.G242W|ACSL1_uc011ckn.1_Missense_Mutation_p.G208W|ACSL1_uc003iwv.1_Missense_Mutation_p.G242W|ACSL1_uc010ise.1_5'Flank	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	242	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACTTCCACCCCACACCTCTGG	0.522			NA											25	103					7.01153e-11	8.67406e-11	0.007291	1	0
TRIML1	339976	broad.mit.edu	37	4	189068505	189068505	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:189068505C>A	uc003izm.1	+	6	1501	c.1386C>A	c.(1384-1386)TGC>TGA	p.C462*	TRIML1_uc003izn.1_Nonsense_Mutation_p.C186*	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	462	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TCACCATCTGCTCACTGAACA	0.562	Melanoma(31;213 1036 16579 23968 32372)		NA											9	30					1.3612e-06	1.55074e-06	0.003163	1	0
SLC6A19	340024	broad.mit.edu	37	5	1212589	1212589	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:1212589C>T	uc003jbw.3	+	4	709	c.653C>T	c.(652-654)ACC>ATC	p.T218I		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	218	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGCATCGAGACCACCGGGAAG	0.672			NA											9	43					0	0	0.006214	0	0
SLC6A19	340024	broad.mit.edu	37	5	1213592	1213592	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:1213592C>A	uc003jbw.3	+	5	734	c.678C>A	c.(676-678)ACC>ACA	p.T226T		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	226	Helical; Name=5; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGTACATCACCTCCACGCTGC	0.527			NA											3	15					0.00024832	0.000270348	0.009096	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5319167	5319167	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:5319167C>A	uc003jdl.2	+	23	3729	c.3591C>A	c.(3589-3591)TGC>TGA	p.C1197*		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1197	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCCACTGGTGCTACCTGGTAC	0.532			NA											41	99					3.54909e-21	5.13809e-21	0.002852	1	0
CTNND2	1501	broad.mit.edu	37	5	11346694	11346694	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:11346694C>A	uc003jfa.1	-	9	1563	c.1418G>T	c.(1417-1419)GGC>GTC	p.G473V	CTNND2_uc010itt.2_Missense_Mutation_p.G382V|CTNND2_uc011cmy.1_Missense_Mutation_p.G136V|CTNND2_uc011cmz.1_Missense_Mutation_p.G40V|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.G40V	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	473					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTGCTGGCTGCCTGTGCGCTG	0.617			NA											11	38					6.40141e-05	7.06904e-05	0.000978	1	0
CDH12	1010	broad.mit.edu	37	5	21765146	21765146	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:21765146G>A	uc010iuc.2	-	9	1914	c.1456C>T	c.(1456-1458)CCT>TCT	p.P486S	CDH12_uc011cno.1_Missense_Mutation_p.P446S|CDH12_uc003jgk.2_Missense_Mutation_p.P486S|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	486	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ATTTCTGGAGGAAATTCATTT	0.338			NA								HNSCC(59;0.17)			14	319					0	0	0.00499	0	0
CDH6	1004	broad.mit.edu	37	5	31297485	31297485	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:31297485C>G	uc003jhe.1	+	4	939	c.613C>G	c.(613-615)CAG>GAG	p.Q205E	CDH6_uc003jhd.1_Missense_Mutation_p.Q205E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	205	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TCTACAGGGACAGCCCTATTT	0.373			NA											20	311					0	0	0.008871	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33631016	33631016	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:33631016G>A	uc003jia.1	-	13	2054	c.1891C>T	c.(1891-1893)CAT>TAT	p.H631Y	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	631	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCACAAGGATGTGCTGAAGGG	0.488			NA								HNSCC(64;0.19)			15	451					0	0	0.008871	0	0
AGXT2	64902	broad.mit.edu	37	5	34998886	34998886	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:34998886C>G	uc003jjf.2	-	14	1562	c.1483G>C	c.(1483-1485)GAT>CAT	p.D495H	AGXT2_uc003jje.1_Missense_Mutation_p.D148H|AGXT2_uc011com.1_Missense_Mutation_p.D420H	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	495					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ACTGCAAAATCAACTTCTGGT	0.358			NA											12	644					0	0	0.00499	0	0
SPEF2	79925	broad.mit.edu	37	5	35691149	35691149	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:35691149G>T	uc003jjo.2	+	11	1646	c.1535G>T	c.(1534-1536)GGA>GTA	p.G512V	SPEF2_uc003jjq.3_Missense_Mutation_p.G512V|SPEF2_uc003jjp.1_Missense_Mutation_p.G3V	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	512					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACATGGTTGGAGAGTGGGCC	0.338			NA											14	59					1.5739e-10	1.92941e-10	0.004007	1	0
SPEF2	79925	broad.mit.edu	37	5	35779450	35779450	+	Splice_Site	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:35779450T>G	uc003jjo.2	+	30	4558	c.4447_splice	c.e30+2	p.G1483_splice	SPEF2_uc003jjp.1_Splice_Site_p.G969_splice|SPEF2_uc003jjr.2_Splice_Site	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACCTAAAGGTAGGAAAAATA	0.388			NA											10	207					0	0	0.006214	0	0
SPEF2	79925	broad.mit.edu	37	5	35793323	35793323	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:35793323G>T	uc003jjo.2	+	32	4728	c.4617G>T	c.(4615-4617)CTG>CTT	p.L1539L	SPEF2_uc003jjp.1_Silent_p.L1025L|SPEF2_uc003jjr.2_Silent_p.L594L	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1539					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAAGTTCCTGTTAGTAACCT	0.448			NA											91	396					1.62402e-62	2.97279e-62	0.00361	1	0
GDNF	2668	broad.mit.edu	37	5	37815930	37815930	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:37815930C>A	uc011cpi.1	-	3	659	c.459G>T	c.(457-459)GAG>GAT	p.E153D	GDNF_uc011cpc.1_Missense_Mutation_p.E75D|GDNF_uc011cpd.1_Missense_Mutation_p.E101D|GDNF_uc011cpe.1_Missense_Mutation_p.E127D|GDNF_uc011cpf.1_Missense_Mutation_p.E127D|GDNF_uc011cpg.1_Missense_Mutation_p.E170D|GDNF_uc011cph.1_Missense_Mutation_p.E144D	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	153					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					CGTACGTTGTCTCAGCTGCAT	0.443			NA											130	327					7.83929e-65	1.44478e-64	0.00361	1	0
RICTOR	253260	broad.mit.edu	37	5	38947422	38947422	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:38947422C>A	uc003jlp.2	-	32	4282	c.4258G>T	c.(4258-4260)GGT>TGT	p.G1420C	RICTOR_uc003jlo.2_Missense_Mutation_p.G1444C|RICTOR_uc010ivf.2_Missense_Mutation_p.G1135C	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1420					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TCATCTGAACCCCCATATGTG	0.383			NA											64	434					3.56499e-28	5.54782e-28	0.00361	1	0
RICTOR	253260	broad.mit.edu	37	5	39021164	39021164	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:39021164C>A	uc003jlp.2	-	3	196	c.172G>T	c.(172-174)GGC>TGC	p.G58C	RICTOR_uc003jlo.2_Missense_Mutation_p.G58C|RICTOR_uc010ivf.2_Translation_Start_Site|RICTOR_uc003jlq.1_Missense_Mutation_p.G42C|RICTOR_uc011cpk.1_Missense_Mutation_p.G58C	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	58					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTCAGATGGCCTAGCTTTCTC	0.328			NA											63	480					1.45978e-39	2.43673e-39	0.00361	1	0
C7	730	broad.mit.edu	37	5	40964907	40964907	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:40964907T>A	uc003jmh.2	+	14	1928	c.1814T>A	c.(1813-1815)CTT>CAT	p.L605H	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	605	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GGATACTCTCTTATTGGAAAC	0.393			NA											38	800					0	0	0.00361	0	0
PARP8	79668	broad.mit.edu	37	5	50091127	50091127	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:50091127G>A	uc003jon.3	+	13	1486	c.1304G>A	c.(1303-1305)AGT>AAT	p.S435N	PARP8_uc011cpz.1_Missense_Mutation_p.S327N|PARP8_uc003joo.2_Missense_Mutation_p.S435N|PARP8_uc003jop.2_Missense_Mutation_p.S435N	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	435						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TCCTACTCCAGTGCCCCCAAG	0.443			NA											30	160					0	0	0.008361	0	0
RAB3C	115827	broad.mit.edu	37	5	58120870	58120870	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:58120870C>A	uc003jrp.2	+	4	474	c.377C>A	c.(376-378)ACT>AAT	p.T126N		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	126					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		TTTAGGTCAACTCAAATCAAA	0.418			NA											68	405					1.7458e-18	2.46789e-18	0.00361	1	0
BDP1	55814	broad.mit.edu	37	5	70797393	70797393	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:70797393A>T	uc003kbp.1	+	14	2224	c.1961A>T	c.(1960-1962)CAC>CTC	p.H654L	BDP1_uc003kbn.1_Missense_Mutation_p.H654L|BDP1_uc003kbo.2_Missense_Mutation_p.H654L	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	654					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCACAGAACCACGTGGAAAAA	0.303			NA											27	117					0	0	0.002445	0	0
RGNEF	64283	broad.mit.edu	37	5	73165952	73165952	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:73165952A>T	uc011csq.1	+	20	2495	c.2484A>T	c.(2482-2484)GCA>GCT	p.A828A	RGNEF_uc003kcx.2_Silent_p.A828A|RGNEF_uc010izf.2_Silent_p.A828A|RGNEF_uc011csr.1_Silent_p.A515A	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	828					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		AGTTTGAAGCAGAATCTTGGA	0.408			NA											94	309					0	0	0.00361	0	0
RGNEF	64283	broad.mit.edu	37	5	73189085	73189085	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:73189085C>T	uc011csq.1	+	27	3641	c.3630C>T	c.(3628-3630)GCC>GCT	p.A1210A	RGNEF_uc003kcx.2_Silent_p.A1210A|RGNEF_uc010izf.2_Silent_p.A1210A|RGNEF_uc011csr.1_Silent_p.A897A|RGNEF_uc003kcz.3_Silent_p.A174A|RGNEF_uc003kda.3_Silent_p.A174A	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1210					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		AAGCTGAAGCCAGAGTGGCCA	0.473			NA											7	13					0	0	0.006214	0	0
IQGAP2	10788	broad.mit.edu	37	5	75757446	75757446	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:75757446G>T	uc003kek.2	+	2	320	c.98G>T	c.(97-99)CGG>CTG	p.R33L		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	33					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAGAGGAGGCGGCAGAACATT	0.423			NA											64	247					1.36236e-49	2.37698e-49	0.00361	1	0
PDE8B	8622	broad.mit.edu	37	5	76607850	76607850	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:76607850C>T	uc003kfa.2	+	2	416	c.371C>T	c.(370-372)CCC>CTC	p.P124L	PDE8B_uc003kfb.2_Intron|PDE8B_uc003kfc.2_Missense_Mutation_p.P124L|PDE8B_uc003kfd.2_Missense_Mutation_p.P124L|PDE8B_uc003kfe.2_Missense_Mutation_p.P124L	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	124					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CGCATCGGGCCCATGAGACTG	0.408			NA											20	673					0	0	0.003954	0	0
JMY	133746	broad.mit.edu	37	5	78610543	78610543	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:78610543G>T	uc003kfx.3	+	9	3048	c.2528G>T	c.(2527-2529)AGA>ATA	p.R843I	JMY_uc003kfw.1_Missense_Mutation_p.R489I	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	843					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GATCTGCCTAGAAAGGAGGGG	0.418			NA											22	118					1.32181e-22	1.95555e-22	0.007291	1	0
RASGRF2	5924	broad.mit.edu	37	5	80408586	80408586	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:80408586C>A	uc003kha.1	+	14	1996	c.1996C>A	c.(1996-1998)CTG>ATG	p.L666M	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	666	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CAACACCTTTCTGCACACCTA	0.512			NA											178	620					5.16896e-63	9.47789e-63	0.00361	1	0
RASGRF2	5924	broad.mit.edu	37	5	80408635	80408635	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:80408635T>C	uc003kha.1	+	14	2045	c.2045T>C	c.(2044-2046)CTC>CCC	p.L682P	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	682	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CTGGGGAAACTCTCCGACATA	0.493			NA											109	358					0	0	0.00361	0	0
VCAN	1462	broad.mit.edu	37	5	82837202	82837202	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:82837202G>C	uc003kii.3	+	8	8736	c.8380G>C	c.(8380-8382)GAG>CAG	p.E2794Q	VCAN_uc003kij.3_Missense_Mutation_p.E1807Q|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.E1458Q	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2794	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAGTGTAACAGAGGTGCCTGA	0.433			NA											25	358					0	0	0.002096	0	0
EDIL3	10085	broad.mit.edu	37	5	83239283	83239283	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:83239283C>G	uc003kio.1	-	11	1817	c.1398G>C	c.(1396-1398)AGG>AGC	p.R466S	EDIL3_uc003kip.1_Missense_Mutation_p.R456S	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	466	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCAATGTGATCCTCCCGTACC	0.488			NA											50	193					0	0	0.00361	0	0
TMEM161B	153396	broad.mit.edu	37	5	87494880	87494880	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:87494880C>A	uc003kjc.2	-	10	1127	c.1002G>T	c.(1000-1002)CTG>CTT	p.L334L	TMEM161B_uc011cty.1_Silent_p.L323L|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_Silent_p.L125L	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	334						integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		AATAAGCTTGCAGGTGACTAC	0.423			NA											13	34					4.7546e-09	5.69287e-09	0.004007	1	0
MEF2C	4208	broad.mit.edu	37	5	88057031	88057031	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:88057031C>A	uc003kjj.2	-	4	1046	c.373G>T	c.(373-375)GAT>TAT	p.D125Y	MEF2C_uc003kji.2_Missense_Mutation_p.D125Y|MEF2C_uc003kjk.2_Missense_Mutation_p.D125Y|MEF2C_uc003kjm.2_Intron|MEF2C_uc003kjl.2_Intron	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	125					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATCATTAGATCAATATCTTCG	0.453			NA								HNSCC(66;0.2)			53	326					4.60343e-24	6.90514e-24	0.00361	1	0
GPR98	84059	broad.mit.edu	37	5	89986703	89986703	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:89986703G>T	uc003kju.2	+	31	6892	c.6796G>T	c.(6796-6798)GGC>TGC	p.G2266C	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2266	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGGGACACTCGGCAATGTTAC	0.458			NA											7	34					0.00198382	0.0020964	0.001984	1	0
MAN2A1	4124	broad.mit.edu	37	5	109117174	109117174	+	Silent	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:109117174G>C	uc003kou.1	+	9	2415	c.1452G>C	c.(1450-1452)TCG>TCC	p.S484S		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	484	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AGGGCCAATCGATGTTCCCTG	0.378			NA											16	94					0	0	0.00278	0	0
WDR36	134430	broad.mit.edu	37	5	110440497	110440497	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:110440497A>T	uc003kpd.2	+	9	1293	c.1176A>T	c.(1174-1176)GGA>GGT	p.G392G	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	392	WD 5.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GACAGAATGGACAGCAGATTC	0.398			NA											47	488					0	0	0.00361	0	0
WDR36	134430	broad.mit.edu	37	5	110446486	110446486	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:110446486G>T	uc003kpd.2	+	14	1727	c.1610_splice	c.e14-1	p.A537_splice	WDR36_uc010jbu.2_Splice_Site	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36						response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CTACCTTACAGCTCACAAGGG	0.373			NA											9	35					0.000673444	0.000722264	0.008291	1	0
CAMK4	814	broad.mit.edu	37	5	110730473	110730473	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:110730473C>A	uc011cvj.1	+	6	551	c.452C>A	c.(451-453)GCA>GAA	p.A151E	CAMK4_uc003kpf.2_Missense_Mutation_p.A151E|CAMK4_uc010jbv.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	151	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATCCTGGAGGCAGTTGCTGTA	0.408			NA											77	265					1.49072e-33	2.39225e-33	0.00361	1	0
PRR16	51334	broad.mit.edu	37	5	120022158	120022158	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:120022158G>T	uc003ksq.2	+	2	832	c.669G>T	c.(667-669)CGG>CGT	p.R223R	PRR16_uc003ksp.2_Silent_p.R200R|PRR16_uc003ksr.2_Silent_p.R153R	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	223	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GTGATACCCGGTATAACATAA	0.512			NA											35	169					2.20914e-33	3.53463e-33	0.002852	1	0
FBN2	2201	broad.mit.edu	37	5	127648343	127648343	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:127648343C>T	uc003kuu.2	-	37	5301	c.4862G>A	c.(4861-4863)TGC>TAC	p.C1621Y		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1621	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GACAGGGGGGCATGTCTCACA	0.512			NA											22	799					0	0	0.003954	0	0
ISOC1	51015	broad.mit.edu	37	5	128440942	128440942	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:128440942G>A	uc003kva.2	+	3	512	c.494G>A	c.(493-495)GGG>GAG	p.G165E		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	165						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		AAAGGTCTTGGGAGCACGGTT	0.383			NA											9	34					0	0	0.000978	0	0
AFF4	27125	broad.mit.edu	37	5	132270357	132270357	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:132270357G>A	uc003kyd.2	-	3	808	c.400C>T	c.(400-402)CAG>TAG	p.Q134*	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Nonsense_Mutation_p.Q134*|AFF4_uc003kyf.3_Nonsense_Mutation_p.Q134*	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	134	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGGTCCGCTGGCTACTATGT	0.532	Ovarian(126;889 1733 2942 10745 11605)		NA											41	95					0	0	0.007835	0	0
BRD8	10902	broad.mit.edu	37	5	137476521	137476521	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:137476521C>T	uc003lcf.1	-	26	3543	c.3488G>A	c.(3487-3489)CGC>CAC	p.R1163H	BRD8_uc003lcc.1_Intron|NME5_uc003lce.2_5'Flank	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1163	Bromo 2.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGCCATGGTGCGAATCCGACC	0.443			NA											28	729					0	0	0.002096	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181997	140181997	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140181997C>T	uc003lhf.2	+	1	1215	c.1215C>T	c.(1213-1215)TAC>TAT	p.Y405Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.Y405Y	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	405	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAATTACTACTCATTGGTGC	0.627			NA											52	129					0	0	0.00361	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222743	140222743	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140222743C>A	uc003lhs.2	+	1	1837	c.1837C>A	c.(1837-1839)CCA>ACA	p.P613T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.P613T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	613	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCTGCAGCCAGCTGCAAG	0.687			NA											13	37					5.01169e-05	5.54005e-05	0.00499	1	0
PCDHA12	56137	broad.mit.edu	37	5	140255192	140255192	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140255192G>T	uc003lic.2	+	1	262	c.135G>T	c.(133-135)GTG>GTT	p.V45V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.V45V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	45	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCTTCGTGGGCCGCATCG	0.657	Pancreas(113;759 1672 13322 24104 50104)		NA											10	16					3.35478e-16	4.55743e-16	0.003163	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553818	140553818	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140553818C>A	uc003lit.2	+	1	1576	c.1402C>A	c.(1402-1404)CTG>ATG	p.L468M		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	468	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCCCCGCCCTGCCCATCGG	0.632			NA											17	71					1.12875e-08	1.33815e-08	0.00632	1	0
PCDHB8	56128	broad.mit.edu	37	5	140559208	140559208	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140559208G>A	uc011dai.1	+	1	1779	c.1593G>A	c.(1591-1593)CGG>CGA	p.R531R	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	531	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGAGTTCCGGGTGGGCGCTT	0.672			NA											4	54					0	0	0.001168	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712339	140712339	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140712339G>T	uc003lji.1	+	1	2088	c.2088G>T	c.(2086-2088)GCG>GCT	p.A696A	PCDHGA1_uc011dan.1_Silent_p.A696A	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	696	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGTGGCGGCGGCCGCGG	0.672			NA											24	67					3.62531e-18	5.10473e-18	0.004289	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140773147	140773147	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140773147C>A	uc003lkd.1	+	1	1665	c.767C>A	c.(766-768)CCC>CAC	p.P256H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.P256H	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	256	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACATGCCCCCAGGCACG	0.488			NA											20	35					2.89027e-11	3.59619e-11	0.002299	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140783353	140783353	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140783353A>T	uc003lkh.1	+	1	834	c.834A>T	c.(832-834)GCA>GCT	p.A278A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.A278A	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	278	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAAGTGGCATACAAATTCT	0.418			NA											27	66					0	0	0.009535	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784676	140784676	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:140784676G>T	uc003lkh.1	+	1	2157	c.2157G>T	c.(2155-2157)TGG>TGT	p.W719C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.W719C	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	719	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGGCACTGGCACTCCTCGC	0.587			NA											19	38					1.33834e-09	1.61138e-09	0.007413	1	0
PPP2R2B	5521	broad.mit.edu	37	5	145979967	145979967	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:145979967A>C	uc003loe.2	-	7	1372	c.847T>G	c.(847-849)TCG>GCG	p.S283A	PPP2R2B_uc010jgm.2_Missense_Mutation_p.S272A|PPP2R2B_uc003log.3_Missense_Mutation_p.S283A|PPP2R2B_uc003lof.3_Missense_Mutation_p.S283A|PPP2R2B_uc003loi.3_Missense_Mutation_p.S286A|PPP2R2B_uc003loh.3_Missense_Mutation_p.S283A|PPP2R2B_uc003loj.3_Missense_Mutation_p.S263A|PPP2R2B_uc003lok.3_Missense_Mutation_p.S272A|PPP2R2B_uc011dbu.1_Missense_Mutation_p.S289A|PPP2R2B_uc011dbv.1_Missense_Mutation_p.S341A	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	283	WD 5.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCGAAATCGAAGAGATAATT	0.423			NA											5	147					0	0	0.000602	0	0
ODZ2	57451	broad.mit.edu	37	5	167525048	167525048	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:167525048C>A	uc010jjd.2	+	9	1729	c.1729C>A	c.(1729-1731)CCA>ACA	p.P577T	ODZ2_uc003lzq.2_Missense_Mutation_p.P456T|ODZ2_uc003lzr.3_Missense_Mutation_p.P345T|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GCAGGACTGTCCACGTAACTG	0.453			NA											28	62					1.26612e-14	1.66757e-14	0.003271	1	0
ZNF354C	30832	broad.mit.edu	37	5	178506336	178506336	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:178506336A>T	uc003mju.2	+	5	1018	c.903A>T	c.(901-903)CGA>CGT	p.R301R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	301	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AACCGTATCGATGTAGGGAAT	0.418			NA											27	245					0	0	0.008361	0	0
DUSP22	56940	broad.mit.edu	37	6	348110	348110	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:348110G>T	uc003msx.2	+	6	710	c.271G>T	c.(271-273)GGG>TGG	p.G91W	DUSP22_uc011dhn.1_Missense_Mutation_p.G91W|DUSP22_uc003msy.1_Missense_Mutation_p.G48W	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	91	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CAGCCTGGCCGGGGTCTCCAG	0.602			NA											17	174					1.77063e-15	2.36962e-15	0.005443	1	0
F13A1	2162	broad.mit.edu	37	6	6318869	6318869	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:6318869C>T	uc003mwv.2	-	2	152	c.29G>A	c.(28-30)GGA>GAA	p.G10E	F13A1_uc011dib.1_Missense_Mutation_p.G10E	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	10					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCTTCTGCCTCCAAAGGCGGT	0.478			NA											87	315					0	0	0.00361	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7987116	7987116	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:7987116C>A	uc003mxx.3	+	1	782	c.347C>A	c.(346-348)ACC>AAC	p.T116N	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						AGCAACCTGACCCCTGCTCAT	0.527			NA											38	112					9.62906e-15	1.26977e-14	0.00623	1	0
SYCP2L	221711	broad.mit.edu	37	6	10930655	10930655	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:10930655C>A	uc003mzo.2	+	19	1837	c.1541C>A	c.(1540-1542)ACC>AAC	p.T514N	SYCP2L_uc011din.1_3'UTR|SYCP2L_uc010jow.2_Missense_Mutation_p.T134N	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	514						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GATTCAAGTACCAGTGAACTA	0.358			NA											10	119					1.76689e-08	2.0878e-08	0.006214	1	0
ATXN1	6310	broad.mit.edu	37	6	16328052	16328052	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:16328052C>A	uc003nbt.2	-	8	1461	c.490G>T	c.(490-492)GGG>TGG	p.G164W	ATXN1_uc010jpi.2_Missense_Mutation_p.G164W|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	164					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GTGGTGGCCCCTGCGGCCGAG	0.627			NA											20	21					9.39395e-14	1.22678e-13	0.00632	1	0
NRSN1	140767	broad.mit.edu	37	6	24134721	24134721	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:24134721A>T	uc010jpq.1	+	3	403	c.166A>T	c.(166-168)AGG>TGG	p.R56W		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	56					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						ATCACCTAACAGGTGGAGCTC	0.453			NA											22	101					0	0	0.008361	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596192	24596192	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:24596192G>C	uc011djo.1	-	3	947	c.710C>G	c.(709-711)CCC>CGC	p.P237R	KIAA0319_uc011djp.1_Missense_Mutation_p.P192R|KIAA0319_uc003neh.1_Missense_Mutation_p.P237R|KIAA0319_uc011djq.1_Missense_Mutation_p.P228R|KIAA0319_uc011djr.1_Missense_Mutation_p.P237R	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	237	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						AGTCGGCAAGGGAAGCAACAC	0.547			NA											5	132					0	0	0.001168	0	0
FAM65B	9750	broad.mit.edu	37	6	24843104	24843104	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:24843104C>G	uc003neo.1	-	14	2082	c.1906G>C	c.(1906-1908)GAT>CAT	p.D636H	FAM65B_uc011djs.1_Missense_Mutation_p.D615H|FAM65B_uc011dju.1_Missense_Mutation_p.D620H|FAM65B_uc003nep.2_Missense_Mutation_p.D586H|FAM65B_uc011djt.1_Missense_Mutation_p.D586H	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	636					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AGAATATCATCCAAATTCATG	0.343			NA											11	42					0	0	0.000978	0	0
SLC17A4	10050	broad.mit.edu	37	6	25769244	25769244	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:25769244C>A	uc003nfe.2	+	3	242	c.123C>A	c.(121-123)CTC>CTA	p.L41L	SLC17A4_uc011djx.1_Silent_p.L41L|SLC17A4_uc003nff.1_5'UTR|SLC17A4_uc003nfg.2_5'UTR	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	41					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GGCTGGCCCTCATCTTGCAGC	0.468			NA											35	123					3.61848e-18	5.10177e-18	0.007835	1	0
ZNF322A	79692	broad.mit.edu	37	6	26637670	26637670	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:26637670G>T	uc003nil.3	-	4	1741	c.1112C>A	c.(1111-1113)ACA>AAA	p.T371K	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	371	C2H2-type 11; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0						AATGTGTACTGTCTGATGTTG	0.438			NA											44	734					1.19451e-25	1.82472e-25	0.00361	1	0
OR2J2	26707	broad.mit.edu	37	6	29141790	29141790	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:29141790T>C	uc011dlm.1	+	1	480	c.378T>C	c.(376-378)GCT>GCC	p.A126A		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTATGTAGCTGTGTGTAGAC	0.453			NA											109	751					0	0	0.00361	0	0
BAT3	7917	broad.mit.edu	37	6	31614237	31614237	+	Silent	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:31614237G>C	uc003nvg.3	-	8	1184	c.870C>G	c.(868-870)CTC>CTG	p.L290L	BAT3_uc003nvf.3_Silent_p.L284L|BAT3_uc003nvh.3_Silent_p.L284L|BAT3_uc003nvi.3_Silent_p.L284L|BAT3_uc011dnw.1_Silent_p.L284L|BAT3_uc011dnx.1_Silent_p.L284L|BAT3_uc003nvj.1_Silent_p.L284L	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	290	4 X 29 AA approximate repeats.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						AGAAGGGCTGGAGGCGACTCT	0.582			NA											7	100					0	0	0.004482	0	0
NOTCH4	4855	broad.mit.edu	37	6	32168740	32168740	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:32168740C>A	uc003obb.2	-	23	4322	c.4183G>T	c.(4183-4185)GAC>TAC	p.D1395Y	NOTCH4_uc003oba.2_Missense_Mutation_p.D58Y|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1395	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCCGGGTGGTCAGGGCCACAG	0.637			NA											23	35					6.00712e-18	8.42557e-18	0.002445	1	0
HLA-DPA1	3113	broad.mit.edu	37	6	33036447	33036447	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:33036447G>A	uc003ocs.1	-	4	794	c.763C>T	c.(763-765)CGG>TGG	p.R255W	HLA-DPA1_uc010juk.2_Missense_Mutation_p.R255W	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	255	Cytoplasmic (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						CCCTGGGCCCGGGGGTCATGG	0.542			NA											6	56					0	0	0.00308	0	0
CUL7	9820	broad.mit.edu	37	6	43020259	43020259	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:43020259C>A	uc003otq.2	-	2	571	c.268G>T	c.(268-270)GGG>TGG	p.G90W	CUL7_uc011dvb.1_Missense_Mutation_p.G142W|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	90					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TGGGAGGGCCCGATGACCTGG	0.587			NA											3	87					0.004672	0.00487985	0.004672	1	0
TTBK1	84630	broad.mit.edu	37	6	43225570	43225570	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:43225570G>A	uc003ouq.1	+	10	1161	c.882G>A	c.(880-882)GAG>GAA	p.E294E		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	294	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CAGTGTTTGAGAACAGCATGA	0.602			NA											4	118					0	0	0.001984	0	0
TDRD6	221400	broad.mit.edu	37	6	46657599	46657599	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:46657599G>T	uc003oyj.2	+	1	1734	c.1734G>T	c.(1732-1734)GTG>GTT	p.V578V	TDRD6_uc010jze.2_Silent_p.V572V	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	578	Tudor 3.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CGGAAAATGTGGACTGGTATG	0.433			NA											69	194					5.88917e-42	9.96913e-42	0.00361	1	0
MEP1A	4224	broad.mit.edu	37	6	46806811	46806811	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:46806811G>T	uc010jzh.1	+	14	2221	c.2179G>T	c.(2179-2181)GCT>TCT	p.A727S	MEP1A_uc011dwg.1_Missense_Mutation_p.A449S|MEP1A_uc011dwh.1_Missense_Mutation_p.A755S|MEP1A_uc011dwi.1_Missense_Mutation_p.A627S	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	727	Helical; (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CGGAGGCACGGCTGGCGTGAT	0.602			NA											48	178					1.11015e-26	1.70549e-26	0.00361	1	0
C6orf138	442213	broad.mit.edu	37	6	47846506	47846506	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:47846506C>G	uc011dwm.1	-	3	2108	c.2023G>C	c.(2023-2025)GTC>CTC	p.V675L	C6orf138_uc011dwn.1_Missense_Mutation_p.V439L	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	692	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						ATTGAGGTGACGCTAAGAATT	0.453			NA											26	95					0	0	0.005443	0	0
DEFB112	245915	broad.mit.edu	37	6	50011302	50011302	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:50011302C>T	uc011dws.1	-	2	328	c.328G>A	c.(328-330)GAC>AAC	p.D110N		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	110					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					TGACGTGAGTCTTTAGGGTAC	0.408			NA											15	64					0	0	0.007413	0	0
IL17F	112744	broad.mit.edu	37	6	52109223	52109223	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:52109223G>T	uc003pam.1	-	1	76	c.5C>A	c.(4-6)ACA>AAA	p.T2K		NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	2					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					GGTCTTCACTGTCATGTTGCG	0.448			NA											9	277					0.00136819	0.00144868	0.001368	1	0
RIMS1	22999	broad.mit.edu	37	6	72806785	72806785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:72806785G>T	uc003pga.2	+	3	456	c.379G>T	c.(379-381)GGG>TGG	p.G127W		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	127	RabBD.|FYVE-type.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GTTTGCTGATGGGTGCGGTCA	0.507			NA											35	93					1.60099e-16	2.19146e-16	0.004878	1	0
CD109	135228	broad.mit.edu	37	6	74440084	74440084	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:74440084A>T	uc003php.2	+	4	719	c.294A>T	c.(292-294)GCA>GCT	p.A98A	CD109_uc010kaz.2_Silent_p.A98A|CD109_uc003phq.2_Silent_p.A98A|CD109_uc010kba.2_Intron	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	98						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TGAACAGTGCAGATGAGATTT	0.373			NA											32	113					0	0	0.009718	0	0
ZNF292	23036	broad.mit.edu	37	6	87966098	87966098	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:87966098G>T	uc003plm.3	+	8	2792	c.2751G>T	c.(2749-2751)TTG>TTT	p.L917F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	917					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ATGGACCATTGTCAAATGGTT	0.443			NA											60	167					2.36135e-34	3.81776e-34	0.00361	1	0
GABRR1	2569	broad.mit.edu	37	6	89895078	89895078	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:89895078G>A	uc003pna.2	-	7	1202	c.747C>T	c.(745-747)CTC>CTT	p.L249L	GABRR1_uc011dzv.1_Silent_p.L226L	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	249	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	ATTCCTGAATGAGGAACTGGG	0.488			NA											13	414					0	0	0.001855	0	0
EPHA7	2045	broad.mit.edu	37	6	93964397	93964397	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:93964397C>T	uc003poe.2	-	14	2741	c.2500G>A	c.(2500-2502)GAA>AAA	p.E834K	EPHA7_uc003pof.2_Missense_Mutation_p.E829K|EPHA7_uc011eac.1_Missense_Mutation_p.E830K	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	834	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TAAGGTCTTTCTCCATAAGAC	0.398			NA											21	102					0	0	0.003954	0	0
FHL5	9457	broad.mit.edu	37	6	97063550	97063550	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:97063550G>T	uc003pos.1	+	7	1162	c.757G>T	c.(757-759)GGG>TGG	p.G253W	FHL5_uc003pot.1_Missense_Mutation_p.G253W	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	253	LIM zinc-binding 4.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CTTTAACTGCGGGAAATGCTC	0.443			NA											39	96					7.70917e-36	1.25579e-35	0.00361	1	0
GPR63	81491	broad.mit.edu	37	6	97246908	97246908	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:97246908T>G	uc010kcl.2	-	3	1178	c.700A>C	c.(700-702)ACA>CCA	p.T234P	GPR63_uc003pou.2_Missense_Mutation_p.T234P	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	234	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GGATTGGTTGTGTACCCAAAC	0.448			NA											56	186					0	0	0.00361	0	0
GPR63	81491	broad.mit.edu	37	6	97247592	97247592	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:97247592C>A	uc010kcl.2	-	3	494	c.16G>T	c.(16-18)GTG>TTG	p.V6L	GPR63_uc003pou.2_Missense_Mutation_p.V6L	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	6	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GCAGTCAACACTGCCGAGAAG	0.463			NA											112	366					1.46217e-58	2.6319e-58	0.00361	1	0
HDAC2	3066	broad.mit.edu	37	6	114270215	114270215	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:114270215C>T	uc003pwd.1	-	8	1051	c.1051G>A	c.(1051-1053)GCT>ACT	p.A351T	HDAC2_uc003pwc.1_Missense_Mutation_p.A227T|HDAC2_uc003pwe.1_Missense_Mutation_p.A227T	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	257	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	AATACCACAGCACTAGGTTGA	0.378			NA											88	216					0	0	0.00361	0	0
LAMA2	3908	broad.mit.edu	37	6	129511367	129511367	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:129511367A>T	uc003qbn.2	+	11	1590	c.1485A>T	c.(1483-1485)GGA>GGT	p.G495G	LAMA2_uc003qbo.2_Silent_p.G495G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	495	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGAAGGAGGAGACTGTAGTC	0.403			NA											38	125					0	0	0.00361	0	0
ENPP3	5169	broad.mit.edu	37	6	131962666	131962666	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:131962666G>C	uc003qcu.3	+	3	497	c.150G>C	c.(148-150)AAG>AAC	p.K50N	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Missense_Mutation_p.K16N|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_Intron|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.K50N	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	50	Extracellular (Potential).|SMB 1.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		AACTGGAAAAGCAAGGTATAC	0.423			NA											4	164					0	0	0.009096	0	0
MYB	4602	broad.mit.edu	37	6	135539023	135539023	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:135539023C>A	uc003qfc.2	+	15	2027	c.1828C>A	c.(1828-1830)CCT>ACT	p.P610T	MYB_uc003qfh.2_Missense_Mutation_p.P731T|MYB_uc003qfi.2_Missense_Mutation_p.P715T|MYB_uc010kgi.2_Missense_Mutation_p.P573T|MYB_uc003qfq.2_Missense_Mutation_p.P728T|MYB_uc010kgj.2_Missense_Mutation_p.P575T|MYB_uc003qfo.2_Missense_Mutation_p.P525T|MYB_uc003qfu.2_Missense_Mutation_p.P607T|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.P236T|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.P422T|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	610					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		TACCTGGGAACCTGCATCCTG	0.517			NA	T	NFIB	adenoid cystic carcinoma								102	266					2.11273e-47	3.66252e-47	0.00361	1	0
SHPRH	257218	broad.mit.edu	37	6	146262871	146262871	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:146262871C>G	uc003qlf.2	-	10	2777	c.2378G>C	c.(2377-2379)CGT>CCT	p.R793P	SHPRH_uc003qld.2_Missense_Mutation_p.R793P|SHPRH_uc003qle.2_Missense_Mutation_p.R793P|SHPRH_uc003qlg.1_Missense_Mutation_p.R349P|SHPRH_uc003qlj.1_Missense_Mutation_p.R682P	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	793	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CCGTAGGCGACGCCCATCCTC	0.468			NA											25	69					0	0	0.005443	0	0
ESR1	2099	broad.mit.edu	37	6	152265375	152265375	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:152265375C>A	uc003qom.3	+	6	1198	c.828C>A	c.(826-828)GGC>GGA	p.G276G	ESR1_uc010kin.2_Silent_p.G276G|ESR1_uc010kio.2_Silent_p.G278G|ESR1_uc010kip.2_Silent_p.G275G|ESR1_uc003qon.3_Silent_p.G276G|ESR1_uc003qoo.3_Silent_p.G276G|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_Intron|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Intron|ESR1_uc011eex.1_Silent_p.G57G|ESR1_uc010kit.1_Silent_p.G13G|ESR1_uc011eey.1_Silent_p.G13G	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	276	Interaction with AKAP13.|Hinge.|Mediates interaction with DNTTIP2.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ATGGGGAGGGCAGGGGTGAAG	0.507			NA											46	154					4.96213e-28	7.71094e-28	0.00361	1	0
SYNE1	23345	broad.mit.edu	37	6	152763330	152763330	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:152763330G>T	uc010kiw.2	-	31	4490	c.3888C>A	c.(3886-3888)ATC>ATA	p.I1296I	SYNE1_uc003qot.3_Silent_p.I1303I|SYNE1_uc003qou.3_Silent_p.I1296I|SYNE1_uc010kjb.1_Silent_p.I1279I|SYNE1_uc003qow.2_Silent_p.I591I|SYNE1_uc003qox.1_Silent_p.I812I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1296	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCGCCTGCGCGATCTGCTGCT	0.557			NA								HNSCC(10;0.0054)			37	76					1.01817e-39	1.70485e-39	0.009718	1	0
LPA	4018	broad.mit.edu	37	6	160977165	160977165	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:160977165T>A	uc003qtl.2	-	31	4985	c.4865A>T	c.(4864-4866)CAG>CTG	p.Q1622L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4130	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TCGATAACTCTGGCCATTACC	0.483			NA											202	484					0	0	0.00361	0	0
WDR27	253769	broad.mit.edu	37	6	170088913	170088913	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:170088913C>A	uc003qwx.2	-	2	709	c.189G>T	c.(187-189)CAG>CAT	p.Q63H	WDR27_uc010kkw.1_Missense_Mutation_p.Q63H|WDR27_uc003qwy.2_Missense_Mutation_p.Q63H|WDR27_uc011egw.1_RNA|WDR27_uc010kkx.2_Missense_Mutation_p.Q63H			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	63	WD 1.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CGTTCAATACCTGATGAGAAG	0.468			NA											151	362					1.3188e-82	2.49878e-82	0.00361	1	0
C7orf27	221927	broad.mit.edu	37	7	2582880	2582880	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:2582880T>C	uc003smi.2	-	6	923	c.881A>G	c.(880-882)CAC>CGC	p.H294R	C7orf27_uc003smh.3_5'Flank|C7orf27_uc003smj.1_3'UTR	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	294					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		GGGTCCCATGTGGGTGGGACC	0.642			NA											2	7					0	0	0.004672	0	0
CARD11	84433	broad.mit.edu	37	7	2985553	2985553	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:2985553C>A	uc003smv.2	-	4	662	c.258G>T	c.(256-258)AGG>AGT	p.R86S		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	86	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCACATAGCCCCTTTGCCCCT	0.493			NA	Mis		DLBCL								78	479					1.31215e-26	2.01296e-26	0.00361	1	0
SDK1	221935	broad.mit.edu	37	7	4153708	4153708	+	Missense_Mutation	SNP	G	G	T	rs142268038		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:4153708G>T	uc003smx.2	+	25	3764	c.3625G>T	c.(3625-3627)GTG>TTG	p.V1209L	SDK1_uc010kso.2_Missense_Mutation_p.V485L	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1209	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCCGAGTCCGTGGGCTACAG	0.587			NA											7	30					2.0095e-06	2.28208e-06	0.001984	1	0
PHF14	9678	broad.mit.edu	37	7	11068427	11068427	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:11068427A>T	uc003sry.1	+	7	1872	c.1437A>T	c.(1435-1437)TCA>TCT	p.S479S	PHF14_uc011jxi.1_Silent_p.S194S|PHF14_uc003srz.2_Silent_p.S479S|PHF14_uc011jxj.1_Silent_p.S194S	NM_014660	NP_055475	O94880	PHF14_HUMAN	PHD finger protein 14 isoform 2	479							zinc ion binding			kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		GTCTGCTTTCAGAGGCAGCGG	0.433			NA											15	136					0	0	0.00333	0	0
THSD7A	221981	broad.mit.edu	37	7	11582602	11582602	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:11582602C>A	uc003ssf.3	-	5	1848	c.1596G>T	c.(1594-1596)CAG>CAT	p.Q532H		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	532	TSP type-1 5.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTTTCCCTTGCTGATCATTAC	0.388			NA								HNSCC(18;0.044)			31	115					1.22384e-17	1.70547e-17	0.002836	1	0
DGKB	1607	broad.mit.edu	37	7	14216490	14216490	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:14216490C>A	uc003ssz.2	-	24	2468	c.2281G>T	c.(2281-2283)GAG>TAG	p.E761*	DGKB_uc011jxt.1_Nonsense_Mutation_p.E742*|DGKB_uc003sta.2_Nonsense_Mutation_p.E761*|DGKB_uc011jxu.1_Nonsense_Mutation_p.E760*	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	761					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	ATCCATGGCTCCCCATCAATT	0.393			NA											214	456					1.62378e-119	3.13157e-119	0.00361	1	0
PRPS1L1	221823	broad.mit.edu	37	7	18067033	18067033	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:18067033T>A	uc003stz.2	-	1	454	c.373A>T	c.(373-375)ATC>TTC	p.I125F		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	125					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCCATGGTGATGATATGATCC	0.463			NA											144	368					0	0	0.00361	0	0
DNAH11	8701	broad.mit.edu	37	7	21631013	21631013	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:21631013C>T	uc003svc.2	+	14	2516	c.2485C>T	c.(2485-2487)CGC>TGC	p.R829C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	829	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGAGTTGAGCGCACACAGAA	0.607			NA							Kartagener_syndrome				28	161					0	0	0.002096	0	0
STK31	56164	broad.mit.edu	37	7	23826529	23826529	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:23826529C>A	uc003sws.3	+	20	2540	c.2473C>A	c.(2473-2475)CCT>ACT	p.P825T	STK31_uc003swt.3_Missense_Mutation_p.P802T|STK31_uc011jze.1_Missense_Mutation_p.P825T|STK31_uc010kuq.2_Missense_Mutation_p.P802T|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	825	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						AGCCAACATGCCTTTAAATTC	0.323			NA											63	521					4.59617e-45	7.91684e-45	0.00361	1	0
HOXA2	3199	broad.mit.edu	37	7	27140626	27140626	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:27140626G>T	uc003syh.2	-	2	1125	c.850C>A	c.(850-852)CTG>ATG	p.L284M		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	284						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AAATGTTTCAGATTTTTCTCA	0.498			NA											20	77					2.39556e-15	3.19803e-15	0.00278	1	0
HOXA7	3204	broad.mit.edu	37	7	27196029	27196029	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:27196029C>G	uc003sys.2	-	1	268	c.136G>C	c.(136-138)GCC>CCC	p.A46P		NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	46					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						GAGGCGAAGGCGCCGGCGCCC	0.622			NA											6	12					0	0	0.001984	0	0
SCRN1	9805	broad.mit.edu	37	7	29980415	29980415	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:29980415C>G	uc010kvp.2	-	4	826	c.622G>C	c.(622-624)GCT>CCT	p.A208P	SCRN1_uc011jzy.1_Missense_Mutation_p.A140P|SCRN1_uc003tak.2_Missense_Mutation_p.A208P|SCRN1_uc011jzz.1_Missense_Mutation_p.A208P|SCRN1_uc011kaa.1_Missense_Mutation_p.A228P|SCRN1_uc011jzw.1_Intron|SCRN1_uc011jzx.1_Missense_Mutation_p.A31P	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	208					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						TGGCTCTGAGCGTAACTCCTG	0.527			NA											31	154					0	0	0.009718	0	0
BBS9	27241	broad.mit.edu	37	7	33545221	33545221	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:33545221G>A	uc003tdn.1	+	20	2775	c.2262G>A	c.(2260-2262)GCG>GCA	p.A754A	BBS9_uc003tdo.1_Silent_p.A719A|BBS9_uc003tdp.1_Silent_p.A749A|BBS9_uc003tdq.1_Silent_p.A714A|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Silent_p.A278A|BBS9_uc003tds.1_Silent_p.A177A|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	754					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TTCTGGAAGCGGCATTTCTGC	0.498			NA							Bardet-Biedl_syndrome				15	141					0	0	0.006122	0	0
KIAA0895	23366	broad.mit.edu	37	7	36396906	36396906	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:36396906C>A	uc003tfd.2	-	3	523	c.472G>T	c.(472-474)GTG>TTG	p.V158L	KIAA0895_uc003tfc.2_Missense_Mutation_p.V145L|KIAA0895_uc011kaw.1_Missense_Mutation_p.V7L|KIAA0895_uc003tfb.2_Missense_Mutation_p.V107L|KIAA0895_uc011kax.1_Missense_Mutation_p.V107L|KIAA0895_uc003tfe.2_Missense_Mutation_p.V145L|KIAA0895_uc011kay.1_Missense_Mutation_p.V107L	NM_001100425	NP_001093895	Q8NCT3	K0895_HUMAN	hypothetical protein LOC23366 isoform 1	158											0						CTGCTTGTCACAGGCACCAGG	0.473			NA											19	60					4.26978e-12	5.41239e-12	0.00333	1	0
GPR141	353345	broad.mit.edu	37	7	37780650	37780650	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:37780650C>A	uc003tfm.1	+	1	655	c.655C>A	c.(655-657)CAG>AAG	p.Q219K	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	219	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						ACTATCCCACCAGGAGTTCTG	0.418			NA											122	533					9.13576e-48	1.58883e-47	0.00361	1	0
HECW1	23072	broad.mit.edu	37	7	43283518	43283518	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:43283518T>A	uc003tid.1	+	3	619	c.14T>A	c.(13-15)CTG>CAG	p.L5Q	HECW1_uc011kbi.1_Missense_Mutation_p.L5Q|HECW1_uc003tie.1_Intron	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	5					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTGCTGCACCTGTGTAGTGTG	0.448			NA											175	373					0	0	0.00361	0	0
MYO1G	64005	broad.mit.edu	37	7	45011815	45011815	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:45011815C>G	uc003tmh.2	-	6	772	c.628G>C	c.(628-630)GGC>CGC	p.G210R	MYO1G_uc003tmg.2_5'UTR|MYO1G_uc010kym.2_Missense_Mutation_p.G95R|MYO1G_uc003tmi.1_Missense_Mutation_p.G122R|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	210	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						TCCTCACTGCCTCTCAGCAAC	0.507			NA											8	21					0	0	0.006214	0	0
ABCA13	154664	broad.mit.edu	37	7	48452087	48452087	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:48452087G>T	uc003toq.2	+	41	12391	c.12366G>T	c.(12364-12366)AAG>AAT	p.K4122N	ABCA13_uc010kys.1_Missense_Mutation_p.K1196N|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4122					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACACAGACAAGGCCTGCTTGA	0.493			NA											63	324					1.07941e-43	1.84457e-43	0.00361	1	0
CDC14C	168448	broad.mit.edu	37	7	48964294	48964294	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:48964294C>A	uc010kyv.1	+	1	138	c.26C>A	c.(25-27)CCG>CAG	p.P9Q		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						CTGCAGGACCCGCGCCGCCGG	0.632			NA											14	10					1.49906e-05	1.6725e-05	0.00245	1	0
DDC	1644	broad.mit.edu	37	7	50596906	50596906	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:50596906C>A	uc003tpf.3	-	5	656	c.570G>T	c.(568-570)CAG>CAT	p.Q190H	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Missense_Mutation_p.Q190H	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	190					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ACACACTCACCTGATCGGATG	0.512			NA											80	177					4.00701e-44	6.86916e-44	0.00361	1	0
COBL	23242	broad.mit.edu	37	7	51096651	51096651	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:51096651C>A	uc003tpr.3	-	10	2327	c.2142G>T	c.(2140-2142)AAG>AAT	p.K714N	COBL_uc003tps.2_Missense_Mutation_p.K771N|COBL_uc011kcl.1_Missense_Mutation_p.K714N|COBL_uc003tpp.3_Missense_Mutation_p.K500N|COBL_uc003tpq.3_Missense_Mutation_p.K655N|COBL_uc003tpo.3_Missense_Mutation_p.K256N	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	714										skin(3)|ovary(2)	5	Glioma(55;0.08)					GCATCTCTGACTTTGGAGGAA	0.522	NSCLC(189;2119 2138 12223 30818 34679)		NA											42	70					1.51926e-22	2.23847e-22	0.00361	1	0
COBL	23242	broad.mit.edu	37	7	51111277	51111277	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:51111277C>A	uc003tpr.3	-	8	1394	c.1209G>T	c.(1207-1209)ACG>ACT	p.T403T	COBL_uc003tps.2_Silent_p.T460T|COBL_uc011kcl.1_Silent_p.T403T|COBL_uc010kzc.2_Silent_p.T403T|COBL_uc003tpp.3_Silent_p.T189T|COBL_uc003tpq.3_Silent_p.T344T	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	403										skin(3)|ovary(2)	5	Glioma(55;0.08)					AGTCCTCGGTCGTGTCCTCCG	0.607	NSCLC(189;2119 2138 12223 30818 34679)		NA											51	95					2.41709e-19	3.43481e-19	0.00361	1	0
VSTM2A	222008	broad.mit.edu	37	7	54617601	54617601	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:54617601A>T	uc010kzf.2	+	4	777	c.372A>T	c.(370-372)TTA>TTT	p.L124F	VSTM2A_uc010kze.2_Missense_Mutation_p.L124F|VSTM2A_uc003tqc.3_Missense_Mutation_p.L124F	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	124	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			ATGAAGGCTTATATGAGTGCA	0.468			NA											8	24					0	0	0.008291	0	0
SEPT14	346288	broad.mit.edu	37	7	55929665	55929665	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:55929665G>T	uc003tqz.2	-	2	142	c.25C>A	c.(25-27)CCC>ACC	p.P9T		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	9					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATTTGTGTGGGCATAGCCATT	0.279			NA											3	29					0.00024832	0.000270348	0.009096	1	0
ZNF713	349075	broad.mit.edu	37	7	55991322	55991322	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:55991322G>T	uc003trc.1	+	3	236	c.198G>T	c.(196-198)GAG>GAT	p.E66D	ZNF713_uc003tra.1_Missense_Mutation_p.E79D|MRPS17_uc003trb.2_Missense_Mutation_p.E66D	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			gtaagccaGAGGTAATCGCGC	0.259			NA											13	73					1.3612e-06	1.55074e-06	0.003163	1	0
ZNF680	340252	broad.mit.edu	37	7	63982636	63982636	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:63982636A>G	uc003tta.2	-	4	669	c.496T>C	c.(496-498)TTT>CTT	p.F166L	ZNF680_uc010kzr.2_Missense_Mutation_p.F93L	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				GAATTTGAAAATTTATGAAAG	0.299			NA											5	71					0	0	0.000602	0	0
RABGEF1	27342	broad.mit.edu	37	7	66264318	66264318	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:66264318G>T	uc011kee.1	+	7	943	c.779G>T	c.(778-780)CGC>CTC	p.R260L	RABGEF1_uc003tvf.2_Missense_Mutation_p.R119L|RABGEF1_uc003tvg.2_Missense_Mutation_p.R54L|RABGEF1_uc010lag.2_Missense_Mutation_p.R246L|RABGEF1_uc003tvh.2_Missense_Mutation_p.R246L|RABGEF1_uc003tvi.2_Missense_Mutation_p.R80L	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	463	VPS9.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						AGAGCCCTGCGCTGGGTTACG	0.493			NA											42	108					6.31075e-24	9.4399e-24	0.00361	1	0
SEMA3A	10371	broad.mit.edu	37	7	83640407	83640407	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:83640407T>C	uc003uhz.2	-	9	1241	c.926A>G	c.(925-927)CAG>CGG	p.Q309R		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	309	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						GAATACATCCTCTGTTTAAAA	0.313			NA											24	46					0	0	0.003954	0	0
GRM3	2913	broad.mit.edu	37	7	86415735	86415735	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:86415735C>T	uc003uid.2	+	3	1726	c.627C>T	c.(625-627)AAC>AAT	p.N209N	GRM3_uc010lef.2_Silent_p.N207N|GRM3_uc010leg.2_Silent_p.N81N|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	209	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCTTCTTCAACTGGACCTACG	0.572	GBM(52;969 1098 3139 52280)		NA											29	154					0	0	0.002096	0	0
CROT	54677	broad.mit.edu	37	7	87011391	87011391	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:87011391G>T	uc003uit.2	+	12	1309	c.1064G>T	c.(1063-1065)GGT>GTT	p.G355V	CROT_uc003uiu.2_Missense_Mutation_p.G383V	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	355					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TATTTTCAGGGTTCAGAGAAG	0.333			NA											88	170					3.59239e-61	6.55368e-61	0.00361	1	0
STEAP4	79689	broad.mit.edu	37	7	87913403	87913403	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:87913403C>T	uc003ujs.2	-	2	287	c.182G>A	c.(181-183)GGT>GAT	p.G61D	STEAP4_uc010lek.2_Missense_Mutation_p.G61D|STEAP4_uc003ujt.2_Missense_Mutation_p.G61D	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	61					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					GACTTCTGCACCACTGGGCAG	0.438			NA											20	128					0	0	0.00278	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963931	88963931	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:88963931G>T	uc011khi.1	+	4	2173	c.1635G>T	c.(1633-1635)TGG>TGT	p.W545C		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	545						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATCCGGATTGGGAAAAATTCC	0.353			NA								HNSCC(36;0.09)			40	105					3.50607e-19	4.97576e-19	0.00361	1	0
SLC25A13	10165	broad.mit.edu	37	7	95750587	95750587	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:95750587T>A	uc003uof.3	-	18	2135	c.1944A>T	c.(1942-1944)GCA>GCT	p.A648A	SLC25A13_uc003uog.3_Silent_p.A649A|SLC25A13_uc011kik.1_Silent_p.A540A	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	648					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TTTCAATCCCTGCAAATGTAG	0.498			NA											13	386					0	0	0.00245	0	0
OCM2	4951	broad.mit.edu	37	7	97617832	97617832	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:97617832G>A	uc003upc.2	-	2	90	c.90C>T	c.(88-90)TTC>TTT	p.F30F		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	30							calcium ion binding				0						ACGTCTGGAAGAATTTTTGGG	0.468			NA											7	452					0	0	0.001984	0	0
SMURF1	57154	broad.mit.edu	37	7	98633309	98633309	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:98633309A>C	uc003upu.1	-	17	2238	c.1918T>G	c.(1918-1920)TTG>GTG	p.L640V	SMURF1_uc003upv.1_Missense_Mutation_p.L614V|SMURF1_uc003upt.2_Missense_Mutation_p.L614V|TRRAP_uc003ups.2_RNA	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	640	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CAGTCGTTCAAGTCTATTTTA	0.522			NA											5	40					0	0	0.001984	0	0
ZAN	7455	broad.mit.edu	37	7	100382441	100382441	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:100382441T>C	uc003uwj.2	+	37	6984	c.6819T>C	c.(6817-6819)CAT>CAC	p.H2273H	ZAN_uc003uwk.2_Silent_p.H2273H|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.H323H	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2273	VWFC 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGGATGCCCATGGTGGCTCCA	0.582			NA											5	52					0	0	0.001984	0	0
MUC17	140453	broad.mit.edu	37	7	100678604	100678604	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:100678604G>T	uc003uxp.1	+	3	3960	c.3907G>T	c.(3907-3909)GTT>TTT	p.V1303F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1303	Extracellular (Potential).|Ser-rich.|19.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACAACTCCTGTTGACACTAA	0.458			NA											130	357					1.18812e-89	2.25911e-89	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100680895	100680895	+	Silent	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:100680895A>C	uc003uxp.1	+	3	6251	c.6198A>C	c.(6196-6198)ACA>ACC	p.T2066T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2066	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCCTTTCAACAACTCCTGTTG	0.488			NA											53	263					0	0	0.00361	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432382	107432382	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:107432382A>G	uc003ver.2	-	4	486	c.275T>C	c.(274-276)TTA>TCA	p.L92S	SLC26A3_uc003ves.2_Missense_Mutation_p.L57S	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	92	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						AGCAAATGCTAAACCTGTAAA	0.423			NA											10	213					0	0	0.006214	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428789	120428789	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:120428789G>C	uc003vjk.2	-	8	1149	c.775C>G	c.(775-777)CAA>GAA	p.Q259E	TSPAN12_uc010lkj.2_Missense_Mutation_p.Q132E	NM_012338	NP_036470	O95859	TSN12_HUMAN	transmembrane 4 superfamily member 12	259	Cytoplasmic (Potential).				angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction					0	all_neural(327;0.117)					GACATCATTTGGTCTGTCCCC	0.468			NA											10	605					0	0	0.001368	0	0
C7orf58	79974	broad.mit.edu	37	7	120911454	120911455	+	Missense_Mutation	DNP	AC	AC	TA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:120911454_120911455AC>TA	uc003vjq.3	+	22	3285_3286	c.2838_2839AC>TA	c.(2836-2841)CTACAG>CTTAAG	p.Q947K		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	947						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AAGAGTTTCTACAGGGGAAGTG	0.327			NA											213	424					0	0	0.004672	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121623757	121623757	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:121623757C>G	uc003vjy.2	+	7	1053	c.658C>G	c.(658-660)CTT>GTT	p.L220V	PTPRZ1_uc003vjz.2_Missense_Mutation_p.L220V	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	220	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACTGTTGAACCTTCTGCCAAA	0.393			NA											140	298					0	0	0.00361	0	0
ASB15	142685	broad.mit.edu	37	7	123257663	123257664	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:123257663_123257664CC>AA	uc003vku.1	+	7	615_616	c.323_324CC>AA	c.(322-324)ACC>AAA	p.T108K	ASB15_uc003vkv.1_Missense_Mutation_p.T108K|ASB15_uc003vkw.1_Missense_Mutation_p.T108K	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	108					intracellular signal transduction					skin(2)|lung(1)	3						GAATTCAAGACCTGTGATGGAG	0.386			NA											77	224					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	7	124116525	124116525	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:124116525G>T	uc011kod.1	+	1	101	c.101G>T	c.(100-102)CGG>CTG	p.R34L		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;												NA						CTAAGTGTCCGGTCTTTCGGA	0.498			NA											34	195					1.90571e-15	2.54723e-15	0.004289	1	0
GRM8	2918	broad.mit.edu	37	7	126173069	126173069	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:126173069G>A	uc003vlr.2	-	8	2678	c.2367C>T	c.(2365-2367)ACC>ACT	p.T789T	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.T789T|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	789	Helical; Name=6; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGATGCAGGTGGTATACATGG	0.408			NA								HNSCC(24;0.065)			17	193					0	0	0.010504	0	0
GRM8	2918	broad.mit.edu	37	7	126173340	126173340	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:126173340G>T	uc003vlr.2	-	8	2407	c.2096C>A	c.(2095-2097)ACC>AAC	p.T699N	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.T699N|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	699	Helical; Name=4; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAGGCTGAAGGTGATCACCAG	0.498			NA								HNSCC(24;0.065)			50	86					3.21867e-24	4.84821e-24	0.00361	1	0
GRM8	2918	broad.mit.edu	37	7	126173694	126173694	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:126173694G>T	uc003vlr.2	-	8	2053	c.1742C>A	c.(1741-1743)TCT>TAT	p.S581Y	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.S581Y|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	581	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGCCCAGGGAGAATGCCACTC	0.512			NA								HNSCC(24;0.065)			13	136					2.61681e-11	3.2597e-11	0.00245	1	0
CCDC136	64753	broad.mit.edu	37	7	128450286	128450286	+	Missense_Mutation	SNP	C	C	A	rs116868322	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:128450286C>A	uc003vnv.1	+	12	2261	c.1894C>A	c.(1894-1896)CAA>AAA	p.Q632K	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.Q448K|CCDC136_uc010llq.1_5'UTR|CCDC136_uc003vny.1_Missense_Mutation_p.Q242K	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	632						integral to membrane	protein binding			ovary(2)	2						GATACAGAACCAAGACTGTGT	0.468			NA											30	25					2.47316e-13	3.21035e-13	0.003271	1	0
TNPO3	23534	broad.mit.edu	37	7	128658125	128658125	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:128658125C>T	uc003vol.1	-	2	581	c.207G>A	c.(205-207)ATG>ATA	p.M69I	TNPO3_uc003vom.1_Missense_Mutation_p.M3I|TNPO3_uc010lly.1_Missense_Mutation_p.M69I|TNPO3_uc010llz.1_Missense_Mutation_p.M69I	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	69					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TCTGAATCTTCATTTTCATGG	0.453	Pancreas(147;583 2585 39696 52331)		NA											6	290					0	0	0.001984	0	0
TSPAN33	340348	broad.mit.edu	37	7	128806740	128806740	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:128806740C>A	uc003vop.1	+	6	810	c.581C>A	c.(580-582)CCT>CAT	p.P194H	TSPAN33_uc003voq.1_Missense_Mutation_p.P26H	NM_178562	NP_848657	Q86UF1	TSN33_HUMAN	tetraspanin 33	194	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTGCCTACTCCTGACCAGGTG	0.557			NA											38	131					1.465e-08	1.73487e-08	0.00874	1	0
PLXNA4	91584	broad.mit.edu	37	7	131866251	131866251	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:131866251G>A	uc003vra.3	-	18	3610	c.3381C>T	c.(3379-3381)TCC>TCT	p.S1127S		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1127	Extracellular (Potential).|IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGATGAGCAGGGACTGGACGT	0.602			NA											49	211					0	0	0.00361	0	0
CREB3L2	64764	broad.mit.edu	37	7	137600584	137600584	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:137600584C>A	uc003vtw.2	-	3	889	c.494G>T	c.(493-495)GGG>GTG	p.G165V	CREB3L2_uc003vtx.1_Missense_Mutation_p.G165V|CREB3L2_uc003vty.3_Missense_Mutation_p.G165V|CREB3L2_uc003vtv.2_Missense_Mutation_p.G102V	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	165	Cytoplasmic (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						TGAGCATACCCCAGTGTTCAT	0.458			NA	T	FUS	fibromyxoid sarcoma								73	151					7.63117e-38	1.26406e-37	0.00361	1	0
MGAM	8972	broad.mit.edu	37	7	141734530	141734530	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:141734530G>T	uc003vwy.2	+	16	1902	c.1848G>T	c.(1846-1848)GCG>GCT	p.A616A		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	616	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTACCTTTGCGGGCTCTGGCA	0.498			NA											22	181					1.42536e-11	1.78583e-11	0.004656	1	0
MGAM	8972	broad.mit.edu	37	7	141755465	141755465	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:141755465C>A	uc003vwy.2	+	28	3476	c.3422C>A	c.(3421-3423)TCC>TAC	p.S1141Y		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1141	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAGCACAGGTCCTATAGGAGA	0.542			NA											41	93					4.86159e-25	7.3951e-25	0.00361	1	0
MGAM	8972	broad.mit.edu	37	7	141765177	141765177	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:141765177C>A	uc003vwy.2	+	38	4581	c.4527C>A	c.(4525-4527)ACC>ACA	p.T1509T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1509	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCGTCATCACCCGCTCCACAT	0.597			NA											15	14					1.02788e-11	1.29233e-11	0.00499	1	0
TRPV5	56302	broad.mit.edu	37	7	142625790	142625790	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:142625790G>T	uc003wby.1	-	6	1022	c.758C>A	c.(757-759)ACT>AAT	p.T253N	TRPV5_uc003wbz.2_Missense_Mutation_p.T253N	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	253	ANK 5.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TCTTACCACAGTGTTACCCTC	0.577			NA											8	36					0.00185496	0.00196215	0.001855	1	0
NOBOX	135935	broad.mit.edu	37	7	144097391	144097391	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:144097391G>A	uc011kue.1	-	5	859	c.859C>T	c.(859-861)CTA>TTA	p.L287L		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	287	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					ATCTTCTCTAGCTCCTCCAGC	0.507			NA											26	48					0	0	0.002445	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147259322	147259322	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:147259322C>A	uc003weu.1	+	12	2386	c.1870C>A	c.(1870-1872)CCT>ACT	p.P624T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	624	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACCTCTGGGGCCTCTGAAAGT	0.413			NA								HNSCC(39;0.1)			124	284					9.82225e-59	1.77096e-58	0.00361	1	0
TMEM176A	55365	broad.mit.edu	37	7	150500824	150500824	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:150500824C>T	uc003whx.1	+	5	537	c.459C>T	c.(457-459)ATC>ATT	p.I153I	TMEM176B_uc003whw.3_5'Flank	NM_018487	NP_060957	Q96HP8	T176A_HUMAN	hepatocellular carcinoma-associated antigen 112	153						integral to membrane				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGCCGCATCTCCAGCTCGA	0.512			NA											26	55					0	0	0.008361	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939644	150939644	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:150939644C>A	uc003wjs.2	-	5	603	c.502G>T	c.(502-504)GCG>TCG	p.A168S	SMARCD3_uc003wjt.2_Missense_Mutation_p.A155S|SMARCD3_uc003wju.2_Missense_Mutation_p.A155S|SMARCD3_uc011kvh.1_Missense_Mutation_p.A168S|SMARCD3_uc010lqa.1_Missense_Mutation_p.A168S	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	168					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCAGGCTTCGCAGGGTTAAAA	0.577			NA											18	46					1.2644e-06	1.44656e-06	0.010504	1	0
MLL3	58508	broad.mit.edu	37	7	151962159	151962159	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:151962159C>A	uc003wla.2	-	8	1367	c.1148G>T	c.(1147-1149)TGG>TTG	p.W383L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	383	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGGACATTGCCAACCTGCACG	0.438	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								28	907					2.12542e-12	2.71651e-12	0.00632	1	0
PAXIP1	22976	broad.mit.edu	37	7	154775016	154775016	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:154775016C>A	uc003wlp.2	-	5	394	c.351G>T	c.(349-351)CTG>CTT	p.L117L	PAXIP1_uc003wlq.1_Silent_p.L83L|PAXIP1_uc011kvs.1_Silent_p.L81L|PAXIP1_uc003wlr.1_Silent_p.L26L	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	117	BRCT 2.|Interaction with PA1 (By similarity).				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CCAAAGCCCACAGGGCACTTC	0.423			NA											4	77					2.0095e-06	2.28208e-06	0.001984	1	0
CSMD1	64478	broad.mit.edu	37	8	2967787	2967787	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:2967787C>A	uc011kwk.1	-	43	6894	c.6504G>T	c.(6502-6504)CCG>CCT	p.P2168P	CSMD1_uc011kwj.1_Silent_p.P1560P|CSMD1_uc010lrg.2_Silent_p.P236P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2168	Extracellular (Potential).|CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTCAGGATCGGATACTCAT	0.502			NA											8	23					3.07112e-06	3.48404e-06	0.000978	1	0
MCPH1	79648	broad.mit.edu	37	8	6338368	6338368	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:6338368C>T	uc003wqi.2	+	11	2175	c.2107C>T	c.(2107-2109)CGT>TGT	p.R703C		NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	703	BRCT 2.					microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GGGAATTGCGCGTGGCTGCTG	0.512	Colon(95;1448 1467 8277 34473 35819)		NA											15	100					0	0	0.006122	0	0
SOX7	83595	broad.mit.edu	37	8	10690446	10690446	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:10690446C>A	uc011kwz.1	-	3	211	c.178G>T	c.(178-180)GTG>TTG	p.V60L	PINX1_uc003wth.2_Missense_Mutation_p.V60L|PINX1_uc003wti.2_Missense_Mutation_p.V60L	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	Error:Variant_position_missing_in_Q9BT81_after_alignment					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		TTATTTTTCACTTGAACTTTA	0.448			NA											4	34					0.00024832	0.000270348	0.009096	1	0
LGI3	203190	broad.mit.edu	37	8	22005801	22005801	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:22005801C>A	uc003xav.2	-	8	1808	c.1519G>T	c.(1519-1521)GAG>TAG	p.E507*	LGI3_uc010ltu.2_Nonsense_Mutation_p.E483*	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	507	EAR 7.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		ACAGCCAGCTCCTGGAACCGT	0.612			NA											5	21					3.59834e-05	3.98177e-05	0.001168	1	0
RHOBTB2	23221	broad.mit.edu	37	8	22868122	22868122	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:22868122C>T	uc003xcq.2	+	7	2229	c.1692C>T	c.(1690-1692)ACC>ACT	p.T564T	RHOBTB2_uc003xcp.2_Silent_p.T586T|RHOBTB2_uc011kzp.1_Silent_p.T571T|uc003xcr.2_Intron	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	564	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GCATGTTCACCTCCAGCCCCG	0.587			NA											24	157					0	0	0.00632	0	0
EBF2	64641	broad.mit.edu	37	8	25744284	25744284	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:25744284C>G	uc003xes.1	-	10	1013	c.996G>C	c.(994-996)AGG>AGC	p.R332S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	332	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding	p.R332S(1)		ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGTAAATGAACCTTCCTGGGG	0.483	Esophageal Squamous(166;1018 1046 3854 8328 13429 13634 14071 26624 32918)		NA											15	71					0	0	0.00499	0	0
C8orf80	389643	broad.mit.edu	37	8	27887919	27887919	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:27887919C>A	uc003xgm.3	-	16	2068	c.1925G>T	c.(1924-1926)GGG>GTG	p.G642V		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	642						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		CTCCAGGCCCCCGAGGATGGC	0.463			NA											8	21					9.70103e-10	1.17325e-09	0.008291	1	0
C8orf80	389643	broad.mit.edu	37	8	27888782	27888782	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:27888782T>C	uc003xgm.3	-	15	2029	c.1886A>G	c.(1885-1887)AAA>AGA	p.K629R		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	629						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		GAAATTTTTTTTGCAGCTATC	0.453			NA											54	343					0	0	0.00361	0	0
RP1	6101	broad.mit.edu	37	8	55538014	55538014	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:55538014T>G	uc003xsd.1	+	4	1720	c.1572T>G	c.(1570-1572)GAT>GAG	p.D524E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	524					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATAACAATGATCAAATGGAGG	0.348	Colon(91;1014 1389 7634 14542 40420)		NA											4	60					0	0	0.000602	0	0
TRIM55	84675	broad.mit.edu	37	8	67064862	67064863	+	Splice_Site	DNP	GG	GG	AT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:67064862_67064863GG>AT	uc003xvv.2	+	8	1462	c.1236_splice	c.e8+1	p.Q412_splice	TRIM55_uc003xvu.2_Splice_Site_p.Q412_splice|TRIM55_uc003xvw.2_Splice_Site_p.Q412_splice|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CTGTGACACAGGTAACCCCTCC	0.54			NA											33	143					0	0	0.004672	0	0
NCOA2	10499	broad.mit.edu	37	8	71056877	71056877	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:71056877C>G	uc003xyn.1	-	13	2974	c.2812G>C	c.(2812-2814)GGA>CGA	p.G938R	NCOA2_uc011lfb.1_Intron	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	938					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GACCCCTTACCTGTGCTACTG	0.363			NA	T	RUNXBP2	AML								13	99					0	0	0.003163	0	0
TRAM1	23471	broad.mit.edu	37	8	71512306	71512306	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:71512306T>A	uc003xyo.1	-	2	305	c.135A>T	c.(133-135)AAA>AAT	p.K45N	TRAM1_uc011lfc.1_Missense_Mutation_p.K14N	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	45	Helical; (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			TGATAGAAGCTTTTGCCGTTA	0.368	Ovarian(85;984 1334 5116 12432 40638)		NA											47	72					0	0	0.00361	0	0
MSC	9242	broad.mit.edu	37	8	72754932	72754932	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:72754932A>T	uc003xyx.1	-	2	903	c.585T>A	c.(583-585)GTT>GTA	p.V195V	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	195					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			TGGCTGCGGAAACTTCTTTGG	0.468			NA											223	437					0	0	0.00361	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75932301	75932301	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:75932301T>A	uc003yan.2	+	12	1606	c.1231T>A	c.(1231-1233)TCA>ACA	p.S411T	CRISPLD1_uc011lfk.1_Missense_Mutation_p.S223T|CRISPLD1_uc011lfl.1_Missense_Mutation_p.S223T	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	411	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TAAGCCTGCTTCACATTGCCC	0.413			NA											17	261					0	0	0.010504	0	0
HNF4G	3174	broad.mit.edu	37	8	76472700	76472700	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:76472700C>A	uc003yaq.2	+	10	1374	c.1104C>A	c.(1102-1104)ATC>ATA	p.I368I	HNF4G_uc003yar.2_Silent_p.I405I	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	368					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CAGACCAGATCTGTAAGTTTA	0.363			NA											20	164					1.00905e-13	1.31298e-13	0.008871	1	0
ZFHX4	79776	broad.mit.edu	37	8	77616685	77616685	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:77616685A>G	uc003yav.2	+	2	749	c.362A>G	c.(361-363)GAC>GGC	p.D121G	ZFHX4_uc003yat.1_Missense_Mutation_p.D121G|ZFHX4_uc003yau.1_Missense_Mutation_p.D121G|ZFHX4_uc003yaw.1_Missense_Mutation_p.D121G	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	121						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAGTTAGAGGACAGTGACGTG	0.478			NA								HNSCC(33;0.089)			13	313					0	0	0.001855	0	0
ZFHX4	79776	broad.mit.edu	37	8	77690476	77690476	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:77690476C>A	uc003yav.2	+	4	3435	c.3048C>A	c.(3046-3048)CCC>CCA	p.P1016P	ZFHX4_uc003yau.1_Silent_p.P1042P|ZFHX4_uc003yaw.1_Silent_p.P1016P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1016						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTGAATCCCGAATCCTGCT	0.483			NA								HNSCC(33;0.089)			195	337					3.39112e-68	6.3145e-68	0.00361	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766770	77766770	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:77766770T>C	uc003yav.2	+	10	7865	c.7478T>C	c.(7477-7479)ATG>ACG	p.M2493T	ZFHX4_uc003yau.1_Missense_Mutation_p.M2538T|ZFHX4_uc003yaw.1_Missense_Mutation_p.M2493T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2493						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGCCCTACATGATATTTGAC	0.547			NA								HNSCC(33;0.089)			92	460					0	0	0.00361	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775904	77775904	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:77775904G>C	uc003yav.2	+	11	10206	c.9819G>C	c.(9817-9819)CAG>CAC	p.Q3273H		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3269	Potential.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGTTgcagcagtaccaacagt	0.323			NA								HNSCC(33;0.089)			12	23					0	0	0.000978	0	0
CNGB3	54714	broad.mit.edu	37	8	87645122	87645122	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:87645122C>A	uc003ydx.2	-	11	1225	c.1179_splice	c.e11-1	p.E393_splice	CNGB3_uc010maj.2_Splice_Site_p.E255_splice	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3						signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TCTCAGATACCTGTGAAAACA	0.303			NA											47	114					5.7761e-15	7.67305e-15	0.00361	1	0
RGS22	26166	broad.mit.edu	37	8	101051202	101051202	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:101051202T>C	uc003yjb.1	-	14	2318	c.2123A>G	c.(2122-2124)TAC>TGC	p.Y708C	RGS22_uc003yja.1_Missense_Mutation_p.Y527C|RGS22_uc003yjc.1_Missense_Mutation_p.Y696C|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	708					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTTTCTTGGTAGAAAAGCTG	0.358			NA											26	194					0	0	0.008361	0	0
RIMS2	9699	broad.mit.edu	37	8	104943527	104943527	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:104943527A>G	uc003yls.2	+	10	1856	c.1615A>G	c.(1615-1617)ATA>GTA	p.I539V	RIMS2_uc003ylp.2_Missense_Mutation_p.I761V|RIMS2_uc003ylw.2_Missense_Mutation_p.I553V|RIMS2_uc003ylq.2_Missense_Mutation_p.I553V|RIMS2_uc003ylr.2_Missense_Mutation_p.I600V|RIMS2_uc003ylt.2_Missense_Mutation_p.I146V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	823	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCACCAATTAATAGTTACAAT	0.338			NA								HNSCC(12;0.0054)			14	126					0	0	0.004007	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814424	106814424	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:106814424A>G	uc003ymd.2	+	8	2137	c.2114A>G	c.(2113-2115)CAC>CGC	p.H705R	ZFPM2_uc011lhs.1_Missense_Mutation_p.H436R	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	705	C2HC-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TACATGGTCCACAAACAGTAT	0.517			NA											45	74					0	0	0.00361	0	0
RSPO2	340419	broad.mit.edu	37	8	109001368	109001368	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:109001368C>A	uc003yms.2	-	3	857	c.199G>T	c.(199-201)GGG>TGG	p.G67W	RSPO2_uc003ymq.2_Translation_Start_Site|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	67					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			TGGCGCATCCCTTCTCTTCGA	0.468			NA											147	295					8.54292e-67	1.58256e-66	0.00361	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110478928	110478928	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:110478928C>A	uc003yne.2	+	50	8639	c.8535C>A	c.(8533-8535)CAC>CAA	p.H2845Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2845	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCAGCTTTCACCGTTTAGCGT	0.438			NA								HNSCC(38;0.096)			50	93					5.66675e-16	7.66929e-16	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113246706	113246706	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:113246706C>A	uc003ynu.2	-	68	10787	c.10628G>T	c.(10627-10629)GGG>GTG	p.G3543V	CSMD3_uc003yns.2_Missense_Mutation_p.G2745V|CSMD3_uc003ynt.2_Missense_Mutation_p.G3503V|CSMD3_uc011lhx.1_Missense_Mutation_p.G3374V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3543	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTATATACCCCTGTAAAATG	0.308			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	333					8.53417e-09	1.01732e-08	0.002836	1	0
CSMD3	114788	broad.mit.edu	37	8	113299394	113299394	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:113299394G>A	uc003ynu.2	-	58	9389	c.9230C>T	c.(9229-9231)ACT>ATT	p.T3077I	CSMD3_uc003yns.2_Missense_Mutation_p.T2279I|CSMD3_uc003ynt.2_Missense_Mutation_p.T3037I|CSMD3_uc011lhx.1_Missense_Mutation_p.T2908I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3077	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATAACGTACAGTACTTTTAGT	0.473			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	374					0	0	0.001855	0	0
CSMD3	114788	broad.mit.edu	37	8	113569119	113569119	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:113569119T>A	uc003ynu.2	-	25	4266	c.4107A>T	c.(4105-4107)CAA>CAT	p.Q1369H	CSMD3_uc003yns.2_Missense_Mutation_p.Q641H|CSMD3_uc003ynt.2_Missense_Mutation_p.Q1329H|CSMD3_uc011lhx.1_Missense_Mutation_p.Q1265H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1369	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAAAGTGGCCTTGGTCACTGA	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			63	139					0	0	0.00361	0	0
CSMD3	114788	broad.mit.edu	37	8	113668510	113668510	+	Silent	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:113668510T>A	uc003ynu.2	-	18	3036	c.2877A>T	c.(2875-2877)TCA>TCT	p.S959S	CSMD3_uc003yns.2_Silent_p.S231S|CSMD3_uc003ynt.2_Silent_p.S919S|CSMD3_uc011lhx.1_Silent_p.S855S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	959	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAAGCAAGGGTGACAGAAGAT	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	149					0	0	0.00278	0	0
CSMD3	114788	broad.mit.edu	37	8	113988292	113988292	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:113988292G>T	uc003ynu.2	-	7	1275	c.1116C>A	c.(1114-1116)AGC>AGA	p.S372R	CSMD3_uc003ynt.2_Missense_Mutation_p.S332R|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	372	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGCAGGTGTGCTAGCAACAG	0.483			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	157					2.94398e-08	3.45974e-08	0.007413	1	0
HAS2	3037	broad.mit.edu	37	8	122641133	122641133	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:122641133T>A	uc003yph.2	-	2	986	c.448A>T	c.(448-450)AAC>TAC	p.N150Y		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	150	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGAAGTTGTTCTTCCAGATA	0.438			NA											34	555					0	0	0.002836	0	0
WDYHV1	55093	broad.mit.edu	37	8	124449458	124449458	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:124449458G>T	uc003yqn.1	+	5	517	c.392G>T	c.(391-393)AGA>ATA	p.R131I	WDYHV1_uc011lij.1_Missense_Mutation_p.R71I|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	131					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						AGGAAATTTAGAGTGATCCGT	0.408			NA											12	104					6.72482e-11	8.32891e-11	0.003163	1	0
FER1L6	654463	broad.mit.edu	37	8	125110055	125110055	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:125110055C>A	uc003yqw.2	+	37	5020	c.4814C>A	c.(4813-4815)ACT>AAT	p.T1605N	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1605	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATCTGGAACACTGAAGATGTC	0.418			NA											145	237					2.89414e-53	5.1073e-53	0.00361	1	0
ADCY8	114	broad.mit.edu	37	8	131797656	131797656	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:131797656G>T	uc003ytd.3	-	16	3382	c.3126C>A	c.(3124-3126)GCC>GCA	p.A1042A	ADCY8_uc010mds.2_Silent_p.A911A	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1042	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGCCTGACACGGCCATGTAGG	0.498			NA								HNSCC(32;0.087)			102	377					1.54771e-57	2.77663e-57	0.00361	1	0
TG	7038	broad.mit.edu	37	8	134125713	134125713	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:134125713C>A	uc003ytw.2	+	44	7661	c.7620C>A	c.(7618-7620)TAC>TAA	p.Y2540*	TG_uc010mdw.2_Nonsense_Mutation_p.Y1299*|TG_uc011ljb.1_Nonsense_Mutation_p.Y909*|TG_uc011ljc.1_Nonsense_Mutation_p.Y673*	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2540					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGCCTTTTACCAGGCACTGC	0.488			NA											72	128					1.02218e-41	1.72763e-41	0.00361	1	0
FAM135B	51059	broad.mit.edu	37	8	139209901	139209901	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:139209901G>A	uc003yuy.2	-	8	852	c.681C>T	c.(679-681)TAC>TAT	p.Y227Y	FAM135B_uc003yux.2_Silent_p.Y128Y|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	227										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGAGGTGATGTAGAAGCTTC	0.582			NA								HNSCC(54;0.14)			32	168					0	0	0.003755	0	0
COL22A1	169044	broad.mit.edu	37	8	139824060	139824060	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:139824060G>T	uc003yvd.2	-	9	1878	c.1431C>A	c.(1429-1431)TCC>TCA	p.S477S		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	477	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAGCTGGGCAGGAGCAGTTGA	0.592			NA								HNSCC(7;0.00092)			129	187					8.32301e-65	1.53132e-64	0.00361	1	0
KIAA0020	9933	broad.mit.edu	37	9	2820099	2820099	+	Splice_Site	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:2820099C>A	uc003zhp.1	-	13	1285	c.1189_splice	c.e13-1	p.G397_splice	KIAA0020_uc010mhc.1_Splice_Site_p.G396_splice|KIAA0020_uc003zhq.1_Splice_Site_p.G396_splice	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein							endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		AGTATTGGCCCTGCAAGAATT	0.403			NA											10	97					2.31682e-05	2.57425e-05	0.003163	1	0
GLDC	2731	broad.mit.edu	37	9	6534776	6534776	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:6534776A>G	uc003zkc.2	-	24	3044	c.2851T>C	c.(2851-2853)TCC>CCC	p.S951P		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	951					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGGTCAGGGAGTGTGGAGAC	0.537			NA											9	122					0	0	0.006214	0	0
PTPRD	5789	broad.mit.edu	37	9	8460541	8460541	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:8460541G>T	uc003zkk.2	-	32	4456	c.3745C>A	c.(3745-3747)CCC>ACC	p.P1249T	PTPRD_uc003zkp.2_Missense_Mutation_p.P838T|PTPRD_uc003zkq.2_Missense_Mutation_p.P838T|PTPRD_uc003zkr.2_Missense_Mutation_p.P833T|PTPRD_uc003zks.2_Missense_Mutation_p.P828T|PTPRD_uc003zkl.2_Missense_Mutation_p.P1240T|PTPRD_uc003zkm.2_Missense_Mutation_p.P1236T|PTPRD_uc003zkn.2_Missense_Mutation_p.P838T|PTPRD_uc003zko.2_Missense_Mutation_p.P835T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1249	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACACCACGGGGTCGGAGTAA	0.433			NA								TSP Lung(15;0.13)			37	389					1.47197e-15	1.97237e-15	0.007835	1	0
FREM1	158326	broad.mit.edu	37	9	14784421	14784421	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:14784421C>A	uc003zlm.2	-	24	4979	c.4389G>T	c.(4387-4389)CAG>CAT	p.Q1463H	FREM1_uc010mic.2_Intron	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1463	CSPG 10.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AGCAAACTGTCTGCCCCACTA	0.458			NA											52	137					1.4709e-25	2.24375e-25	0.00361	1	0
C9orf93	203238	broad.mit.edu	37	9	15745522	15745522	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:15745522A>C	uc003zmd.2	+	18	2879	c.2564A>C	c.(2563-2565)AAG>ACG	p.K855T	C9orf93_uc003zme.2_Missense_Mutation_p.K770T|C9orf93_uc011lmu.1_Missense_Mutation_p.K863T|C9orf93_uc003zmf.1_Missense_Mutation_p.K163T	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	855											0				GBM - Glioblastoma multiforme(50;4.84e-07)		GAACATCAAAAGGAGCAGTTG	0.333			NA											133	416					0	0	0.00361	0	0
C9orf72	203228	broad.mit.edu	37	9	27556699	27556699	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:27556699C>T	uc003zqq.2	-	8	1048	c.951G>A	c.(949-951)CAG>CAA	p.Q317Q		NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	317										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		AGGGTGGCATCTGCTTCACAG	0.473			NA											12	176					0	0	0.003163	0	0
TOPORS	10210	broad.mit.edu	37	9	32544246	32544246	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:32544246C>G	uc003zrb.2	-	3	444	c.277G>C	c.(277-279)GTA>CTA	p.V93L	TOPORS_uc003zrc.2_Missense_Mutation_p.V26L	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	93	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TCAGCTGGTACTGTCTGTTGC	0.373			NA											7	102					0	0	0.006214	0	0
TAF1L	138474	broad.mit.edu	37	9	32633786	32633787	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:32633786_32633787CC>AA	uc003zrg.1	-	1	1881_1882	c.1791_1792GG>TT	c.(1789-1794)CAGGGT>CATTGT	p.597_598QG>HC	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	597_598					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCCCGAAGACCCTGTTGCTTGG	0.48			NA											137	331					0	0	0.004672	0	0
C9orf131	138724	broad.mit.edu	37	9	35045842	35045842	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:35045842C>A	uc003zvw.2	+	2	3245	c.3216C>A	c.(3214-3216)CCC>CCA	p.P1072P	C9orf131_uc003zvu.2_Silent_p.P1024P|C9orf131_uc003zvv.2_Silent_p.P999P|C9orf131_uc003zvx.2_Silent_p.P1037P	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	1072											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ACCATCGACCCCTACCCACCA	0.517			NA											116	393					5.22802e-61	9.52151e-61	0.00361	1	0
IGFBPL1	347252	broad.mit.edu	37	9	38414155	38414155	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:38414155C>A	uc004aba.2	-	2	529	c.506G>T	c.(505-507)GGG>GTG	p.G169V		NM_001007563	NP_001007564	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like	169	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding				0				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CACCTGCGCCCCGGTGACGTT	0.557			NA											15	76					4.35082e-09	5.21519e-09	0.010504	1	0
FAM75A3	727830	broad.mit.edu	37	9	40702834	40702834	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:40702834A>C	uc010mmj.2	+	4	520	c.491A>C	c.(490-492)GAT>GCT	p.D164A		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	164	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CATCCTCAGGATCTGGCCTCC	0.587			NA											81	373					0	0	0.00361	0	0
FAM75A3	727830	broad.mit.edu	37	9	40702836	40702836	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:40702836C>T	uc010mmj.2	+	4	522	c.493C>T	c.(493-495)CTG>TTG	p.L165L		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	165	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCCTCAGGATCTGGCCTCCAC	0.587			NA											74	354					0	0	0.00361	0	0
PRUNE2	158471	broad.mit.edu	37	9	79234264	79234264	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:79234264C>A	uc010mpk.2	-	18	9352	c.9228G>T	c.(9226-9228)ATG>ATT	p.M3076I	PRUNE2_uc011lsk.1_Missense_Mutation_p.M325I|PRUNE2_uc011lsl.1_Missense_Mutation_p.M340I|PRUNE2_uc011lsm.1_Intron|PRUNE2_uc004akj.3_Missense_Mutation_p.M530I	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	3076					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ACTCCTTCTCCATAGAAGACA	0.428			NA											5	66					0.00116845	0.00123961	0.001168	1	0
GNAQ	2776	broad.mit.edu	37	9	80537207	80537207	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:80537207C>A	uc004akw.2	-	2	232	c.191G>T	c.(190-192)GGG>GTG	p.G64V		NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	64					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						GTATCCTGACCCATGGATGAT	0.483			NA	Mis		uveal melanoma								181	634					4.16634e-53	7.34037e-53	0.00361	1	0
CEP78	84131	broad.mit.edu	37	9	80869847	80869847	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:80869847T>C	uc004akx.2	+	11	1623	c.1347T>C	c.(1345-1347)CCT>CCC	p.P449P	CEP78_uc004aky.3_Silent_p.P450P|CEP78_uc010mpp.2_Silent_p.P450P	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	449					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						ATGAAGTGCCTGAGAAAACTA	0.378			NA											3	80					0	0	0.009096	0	0
KIF27	55582	broad.mit.edu	37	9	86506225	86506225	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:86506225T>A	uc004ana.2	-	6	1938	c.1794A>T	c.(1792-1794)AGA>AGT	p.R598S	KIF27_uc010mpw.2_Missense_Mutation_p.R598S|KIF27_uc010mpx.2_Missense_Mutation_p.R598S	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	598					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TGGAATCTTGTCTTGATGGGA	0.358			NA											22	163					0	0	0.004656	0	0
C9orf64	84267	broad.mit.edu	37	9	86570403	86570403	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:86570403C>A	uc004anb.2	-	2	738	c.490G>T	c.(490-492)GGA>TGA	p.G164*	C9orf64_uc004anc.2_Nonsense_Mutation_p.G23*	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	164											0						AAAGAGCCTCCAAACTTCTCC	0.443			NA											14	43					0.00316338	0.00333312	0.003163	1	0
Unknown	0	broad.mit.edu	37	9	90747884	90747884	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:90747884T>C	uc011lti.1	-	3	352	c.323A>G	c.(322-324)CAG>CGG	p.Q108R						SubName: Full=cDNA FLJ59639;												NA						GCCTCACCTCTGCAGTTGTGA	0.627			NA											13	302					0	0	0.006122	0	0
NFIL3	4783	broad.mit.edu	37	9	94172835	94172835	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:94172835C>A	uc004arh.2	-	2	577	c.182G>T	c.(181-183)CGG>CTG	p.R61L		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	61					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						CCGTTTCCTCCGACATGCAGA	0.433	Esophageal Squamous(152;732 1832 10053 26981 51762)		NA											52	231					2.84144e-21	4.13578e-21	0.00361	1	0
OGN	4969	broad.mit.edu	37	9	95165620	95165621	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:95165620_95165621GG>TT	uc004asa.2	-	2	304_305	c.69_70CC>AA	c.(67-72)ACCCAG>ACAAAG	p.Q24K	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Missense_Mutation_p.Q24K|OGN_uc011ltx.1_Missense_Mutation_p.Q42K	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein	24						extracellular space|proteinaceous extracellular matrix	growth factor activity				0						GAGTCCTGCTGGGTTGGTGGTG	0.381			NA											34	85					0	0	0.004672	0	0
FAM120A	23196	broad.mit.edu	37	9	96318676	96318676	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:96318676G>T	uc004atw.2	+	13	2312	c.2287G>T	c.(2287-2289)GAT>TAT	p.D763Y	FAM120A_uc004aty.2_Missense_Mutation_p.D544Y|FAM120A_uc004atz.2_Missense_Mutation_p.D412Y|FAM120A_uc010mrg.2_Missense_Mutation_p.D76Y	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	763						cytoplasm|plasma membrane	RNA binding				0						TGAGAACCTAGATCCCCGAGG	0.388			NA											6	94					0.00116845	0.00123961	0.001168	1	0
HEMGN	55363	broad.mit.edu	37	9	100693342	100693342	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:100693342C>A	uc004axy.2	-	3	443	c.335G>T	c.(334-336)GGG>GTG	p.G112V	HEMGN_uc004axz.2_Missense_Mutation_p.G112V	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	112					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GGTTATGCTCCCAGGTGGCTC	0.423			NA											7	64					0.000157383	0.000172213	0.00308	1	0
COL15A1	1306	broad.mit.edu	37	9	101817383	101817383	+	Splice_Site	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:101817383G>T	uc004azb.1	+	33	3238	c.3032_splice	c.e33-1	p.G1011_splice		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTCTTTTTCAGGTCCTCCACT	0.353			NA											17	255					1.10513e-12	1.42089e-12	0.002299	1	0
PPP3R2	5535	broad.mit.edu	37	9	104356802	104356802	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:104356802G>T	uc004bbr.2	-	1	482	c.411C>A	c.(409-411)GAC>GAA	p.D137E	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	134	EF-hand 4.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	TGATGGTTTTGTCGACCAGCT	0.522			NA											11	80					9.70103e-10	1.17325e-09	0.008291	1	0
OR13C4	138804	broad.mit.edu	37	9	107288712	107288712	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:107288712G>T	uc011lvn.1	-	1	779	c.779C>A	c.(778-780)GCA>GAA	p.A260E		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTAGGTTTTGCATACATAAA	0.468			NA											16	201					1.15088e-07	1.33507e-07	0.004007	1	0
OR13C5	138799	broad.mit.edu	37	9	107361248	107361248	+	Missense_Mutation	SNP	C	C	A	rs141723124	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:107361248C>A	uc011lvp.1	-	1	447	c.447G>T	c.(445-447)TGG>TGT	p.W149C		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CTCCTATGATCCAGGACCCAG	0.458			NA											51	594					6.34439e-16	8.57565e-16	0.00361	1	0
OR13C2	392376	broad.mit.edu	37	9	107367610	107367610	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:107367610T>A	uc011lvq.1	-	1	299	c.299A>T	c.(298-300)CAG>CTG	p.Q100L		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGGAACATCTGCACTGCACA	0.522			NA											20	441					0	0	0.00361	0	0
OR13C2	392376	broad.mit.edu	37	9	107367620	107367620	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:107367620A>T	uc011lvq.1	-	1	289	c.289T>A	c.(289-291)TGT>AGT	p.C97S		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGCACTGCACAGCCAGAAAGG	0.532			NA											9	379					0	0	0.00361	0	0
SLC44A1	23446	broad.mit.edu	37	9	108136969	108136969	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:108136969G>T	uc004bcn.2	+	13	1806	c.1585G>T	c.(1585-1587)GTG>TTG	p.V529L	SLC44A1_uc010mtk.1_Missense_Mutation_p.V529L|SLC44A1_uc004bco.1_Missense_Mutation_p.V321L	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	529	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TGCTTTGCGAGTGGCTACCAT	0.393			NA											109	310					7.82945e-61	1.42354e-60	0.00361	1	0
MUSK	4593	broad.mit.edu	37	9	113563158	113563158	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:113563158C>A	uc004bey.2	+	14	2598	c.2500C>A	c.(2500-2502)CTC>ATC	p.L834I	MUSK_uc004bez.1_Missense_Mutation_p.L414I	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	834	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						GCTGTACAATCTCATGCGTCT	0.542			NA											43	140					3.39706e-21	4.92459e-21	0.00361	1	0
OR2K2	26248	broad.mit.edu	37	9	114090593	114090593	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:114090593C>T	uc011lwp.1	-	1	121	c.121G>A	c.(121-123)GGC>AGC	p.G41S		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	70	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTGCTGTTGCCCAAGAGCGTT	0.413			NA											18	473					0	0	0.002299	0	0
C9orf84	158401	broad.mit.edu	37	9	114538232	114538232	+	Missense_Mutation	SNP	G	G	T	rs56921768		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:114538232G>T	uc004bfr.2	-	3	224	c.89C>A	c.(88-90)ACC>AAC	p.T30N	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.T94N	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	30										ovary(2)	2						ATTAATCTGGGTCACCATTCT	0.318			NA											25	102					7.26314e-15	9.58948e-15	0.007291	1	0
COL27A1	85301	broad.mit.edu	37	9	117027389	117027389	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:117027389C>T	uc011lxl.1	+	31	3338	c.3338C>T	c.(3337-3339)CCT>CTT	p.P1113L	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1113	Pro-rich.|Collagen-like 8.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						AGAGGCTTTCCTGTAAGTAGC	0.547			NA											26	46					0	0	0.003954	0	0
TNC	3371	broad.mit.edu	37	9	117826978	117826978	+	Nonsense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:117826978A>C	uc004bjj.3	-	11	3797	c.3435T>G	c.(3433-3435)TAT>TAG	p.Y1145*	TNC_uc010mvf.2_Nonsense_Mutation_p.Y1145*	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1145	Fibronectin type-III 6.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GGATCACCCCATAGATGGAGA	0.537			NA											65	570					0	0	0.00361	0	0
TTLL11	158135	broad.mit.edu	37	9	124751501	124751501	+	Silent	SNP	C	C	G	rs144762491		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:124751501C>G	uc004blt.1	-	4	1700	c.1512G>C	c.(1510-1512)ACG>ACC	p.T504T	TTLL11_uc011lyl.1_Silent_p.T504T|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Silent_p.T181T|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	504	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CCGGCCTCCCCGTGGGGATGT	0.577			NA											8	188					0	0	0.001855	0	0
OR1J4	26219	broad.mit.edu	37	9	125281931	125281931	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:125281931A>T	uc011lyw.1	+	1	512	c.512A>T	c.(511-513)GAC>GTC	p.D171V		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTTGTGCTGACAACACCATC	0.512			NA											15	165					0	0	0.00245	0	0
OR1N2	138882	broad.mit.edu	37	9	125315646	125315646	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:125315646C>G	uc011lyx.1	+	1	198	c.198C>G	c.(196-198)ATC>ATG	p.I66M		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	66	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TCCTGGCCATCAGCTCTGACC	0.527			NA											102	706					0	0	0.00361	0	0
DENND1A	57706	broad.mit.edu	37	9	126641241	126641241	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:126641241C>A	uc004bnz.1	-	2	310	c.77G>T	c.(76-78)GGC>GTC	p.G26V	DENND1A_uc011lzm.1_Intron|DENND1A_uc004boa.1_Missense_Mutation_p.G26V|DENND1A_uc004bob.1_Missense_Mutation_p.A11S|DENND1A_uc004boc.2_Missense_Mutation_p.A11S	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	26	UDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TGAAAGAGTGCCACCTGTCCT	0.358			NA											56	521					1.88225e-35	3.0523e-35	0.00361	1	0
GARNL3	84253	broad.mit.edu	37	9	130073925	130073925	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:130073925C>G	uc011mae.1	+	3	631	c.230C>G	c.(229-231)GCC>GGC	p.A77G	GARNL3_uc011mad.1_Missense_Mutation_p.A55G	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	77					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AATGCAACTGCCCTGCCTGGT	0.413			NA											32	351					0	0	0.006999	0	0
GARNL3	84253	broad.mit.edu	37	9	130101923	130101923	+	Splice_Site	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:130101923G>A	uc011mae.1	+	13	1430	c.1029_splice	c.e13-1	p.R343_splice	GARNL3_uc011mad.1_Splice_Site_p.R321_splice|GARNL3_uc004bqt.1_Splice_Site_p.R124_splice	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCTCTACTTAGGCTGAAAATA	0.284			NA											12	144					0	0	0.001855	0	0
STXBP1	6812	broad.mit.edu	37	9	130420719	130420719	+	Missense_Mutation	SNP	C	C	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:130420719C>G	uc004brl.2	+	4	432	c.235C>G	c.(235-237)CCA>GCA	p.P79A	STXBP1_uc004brk.2_Missense_Mutation_p.P79A	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	79					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						TCTCATCACTCCATCCGAGAA	0.483			NA											45	331					0	0	0.00361	0	0
LAMC3	10319	broad.mit.edu	37	9	133914297	133914297	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:133914297G>T	uc004caa.1	+	5	1121	c.1023G>T	c.(1021-1023)GAG>GAT	p.E341D		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	341	Laminin EGF-like 2.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTGATCGGGAGCTCTTCCGCA	0.617			NA											8	96					0.000978159	0.00104699	0.000978	1	0
COL5A1	1289	broad.mit.edu	37	9	137646119	137646119	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:137646119G>T	uc004cfe.2	+	16	2156	c.1774G>T	c.(1774-1776)GGT>TGT	p.G592C		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	592	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCCTGGCAGGGTCCTCGAGG	0.627			NA											5	8					0.000602214	0.000648446	0.000602	1	0
COL5A1	1289	broad.mit.edu	37	9	137658860	137658860	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:137658860G>T	uc004cfe.2	+	23	2530	c.2148G>T	c.(2146-2148)GAG>GAT	p.E716D		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	716	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCAGGGAGAGCCTGGCCCCC	0.652			NA											3	4					0.004672	0.00487985	0.004672	1	0
SDCCAG3	10807	broad.mit.edu	37	9	139301896	139301896	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:139301896G>A	uc004chi.2	-	5	725	c.520C>T	c.(520-522)CTG>TTG	p.L174L	SDCCAG3_uc004chj.2_Silent_p.L151L|SDCCAG3_uc004chk.2_Silent_p.L101L	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	174						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		TCCTCATCCAGGAGGTCACCA	0.647			NA											4	3					0	0	0.000602	0	0
ARSF	416	broad.mit.edu	37	X	3002623	3002623	+	Missense_Mutation	SNP	G	G	C	rs148764513		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:3002623G>C	uc004cre.1	+	6	967	c.746G>C	c.(745-747)CGG>CCG	p.R249P	ARSF_uc004crf.1_Missense_Mutation_p.R249P	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	249						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTCCTCATGCGGGGGCACGAG	0.493			NA											28	36					0	0	0.003271	0	0
MXRA5	25878	broad.mit.edu	37	X	3241316	3241316	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:3241316A>C	uc004crg.3	-	5	2567	c.2410T>G	c.(2410-2412)TTG>GTG	p.L804V		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	804						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTTTTAATCAATGGGGGTACT	0.473			NA											10	242					0	0	0.001368	0	0
HDHD1A	8226	broad.mit.edu	37	X	6995465	6995465	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:6995465C>A	uc004crv.2	-	3	383	c.306G>T	c.(304-306)CTG>CTT	p.L102L	HDHD1A_uc011mhm.1_Silent_p.L125L|HDHD1A_uc011mhn.1_Silent_p.L59L|HDHD1A_uc010ndl.2_Intron|HDHD1A_uc011mho.1_Silent_p.L102L	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	102					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				CATGTTTCCGCAGGTGGATGA	0.592			NA											10	44					2.31682e-05	2.57425e-05	0.003163	1	0
CLCN4	1183	broad.mit.edu	37	X	10176257	10176257	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:10176257G>C	uc004csy.3	+	9	1446	c.1016G>C	c.(1015-1017)GGG>GCG	p.G339A	CLCN4_uc011mid.1_Missense_Mutation_p.G245A	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	339	Helical; (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ATCCTGCTTGGGGTCTTCGGG	0.572	Melanoma(74;1050 1296 1576 30544 38374)		NA											9	245					0	0	0.003163	0	0
ARHGAP6	395	broad.mit.edu	37	X	11187673	11187673	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:11187673G>T	uc004cup.1	-	9	2634	c.1761C>A	c.(1759-1761)ATC>ATA	p.I587I	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Silent_p.I587I|ARHGAP6_uc004cum.1_Silent_p.I384I|ARHGAP6_uc004cun.1_Silent_p.I407I|ARHGAP6_uc010neb.1_Silent_p.I409I|ARHGAP6_uc011mif.1_Silent_p.I384I	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	587	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CAACAGCGATGATGGCCGTGC	0.493			NA											128	194					3.58306e-76	6.72993e-76	0.00361	1	0
BEND2	139105	broad.mit.edu	37	X	18209221	18209221	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:18209221G>T	uc004cyj.3	-	8	1342	c.1188C>A	c.(1186-1188)GGC>GGA	p.G396G	BEND2_uc010nfb.2_Silent_p.G305G	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	396										ovary(3)|kidney(1)|central_nervous_system(1)	5						TCATTTGTGGGCCAGATTCTG	0.264			NA											82	131					3.47606e-37	5.73151e-37	0.00361	1	0
FAM48B2	170067	broad.mit.edu	37	X	24330389	24330389	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:24330389C>A	uc011mjw.1	-	1	1044	c.1044G>T	c.(1042-1044)TGG>TGT	p.W348C		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	348											0						GCTTGGTGTCCCAGGCCTGAC	0.542			NA											50	72					8.18108e-13	1.05436e-12	0.00361	1	0
PCYT1B	9468	broad.mit.edu	37	X	24597530	24597530	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:24597530T>A	uc004dbi.2	-	6	844	c.611A>T	c.(610-612)GAC>GTC	p.D204V	PCYT1B_uc004dbk.3_Missense_Mutation_p.D204V|PCYT1B_uc004dbj.2_Missense_Mutation_p.D186V	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	204	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	GGTAATGATGTCCGATGTTGA	0.428			NA											241	389					0	0	0.00361	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999351	27999351	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:27999351G>T	uc004dbx.1	-	1	216	c.101C>A	c.(100-102)GCG>GAG	p.A34E		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	34										ovary(3)|skin(1)	4						TGAGGAGGCCGCCGTCACCGC	0.562			NA											11	17					6.72482e-11	8.32891e-11	0.003163	1	0
FAM47C	442444	broad.mit.edu	37	X	37026967	37026967	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:37026967G>C	uc004ddl.1	+	1	498	c.484G>C	c.(484-486)GCA>CCA	p.A162P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	162										ovary(3)	3						GCTGGAGGACGCAGGCTCTTG	0.582			NA											22	16					0	0	0.00278	0	0
FAM47C	442444	broad.mit.edu	37	X	37027514	37027514	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:37027514C>T	uc004ddl.1	+	1	1045	c.1031C>T	c.(1030-1032)CCA>CTA	p.P344L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	344										ovary(3)	3						AGTCTCCACCCAGAGCCTCCC	0.622			NA											25	33					0	0	0.002445	0	0
RPGR	6103	broad.mit.edu	37	X	38146246	38146246	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:38146246C>A	uc004ded.1	-	15	2174	c.2006G>T	c.(2005-2007)TGG>TTG	p.W669L	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						cTCATCTTGCCAGTGTTCTGC	0.289			NA											9	24					0.00829132	0.0086268	0.008291	1	0
MID1IP1	58526	broad.mit.edu	37	X	38664295	38664295	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:38664295G>A	uc004dei.3	+	3	520	c.96G>A	c.(94-96)GTG>GTA	p.V32V	MID1IP1_uc010ngz.2_Silent_p.V32V|MID1IP1_uc004dej.3_Silent_p.V32V	NM_001098790	NP_001092260	Q9NPA3	M1IP1_HUMAN	MID1 interacting G12-like protein	32					lipid biosynthetic process|negative regulation of microtubule depolymerization|positive regulation of fatty acid biosynthetic process|positive regulation of ligase activity|protein polymerization	cytosol|microtubule|nucleus					0						ACCAGACGGTGATGGTGCCCA	0.602			NA											21	27					0	0	0.00333	0	0
USP9X	8239	broad.mit.edu	37	X	41043661	41043661	+	Silent	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:41043661C>T	uc004dfb.2	+	23	3924	c.3291C>T	c.(3289-3291)GCC>GCT	p.A1097A	USP9X_uc004dfc.2_Silent_p.A1097A	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1097					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TAGTCTATGCCTTGTTAATGC	0.398	Ovarian(172;1807 2695 35459 49286)		NA											26	55					0	0	0.008361	0	0
ZC4H2	55906	broad.mit.edu	37	X	64139003	64139003	+	Silent	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:64139003A>T	uc004dvu.2	-	4	568	c.480T>A	c.(478-480)GCT>GCA	p.A160A	ZC4H2_uc004dvv.2_Silent_p.A137A|ZC4H2_uc011mov.1_Silent_p.A137A|ZC4H2_uc011mow.1_Intron|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	160							metal ion binding|protein binding			ovary(1)	1						GTTGGGCGGCAGCGGCTGCAG	0.582			NA											19	29					0	0	0.002836	0	0
HEPH	9843	broad.mit.edu	37	X	65417580	65417580	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:65417580G>T	uc011moz.1	+	10	1626	c.1566G>T	c.(1564-1566)TGG>TGT	p.W522C	HEPH_uc004dwn.2_Missense_Mutation_p.W522C|HEPH_uc004dwo.2_Missense_Mutation_p.W252C|HEPH_uc010nkr.2_Intron|HEPH_uc011mpa.1_Missense_Mutation_p.W522C	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	519	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CATACCGCTGGACAGTCCCCC	0.488			NA											59	83					2.49387e-53	4.40814e-53	0.00361	1	0
EDA2R	60401	broad.mit.edu	37	X	65824892	65824892	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:65824892G>A	uc004dwq.2	-	2	275	c.264C>T	c.(262-264)CCC>CCT	p.P88P	EDA2R_uc004dwr.2_Silent_p.P88P|EDA2R_uc004dws.2_Silent_p.P88P|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Intron|EDA2R_uc010nkt.1_Silent_p.P88P|EDA2R_uc004dwt.1_Silent_p.P88P	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	88	TNFR-Cys 3.|Extracellular (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						AAGCTCACCTGGGCAAACAGT	0.478			NA											19	28					0	0	0.008871	0	0
GJB1	2705	broad.mit.edu	37	X	70443680	70443680	+	Missense_Mutation	SNP	G	G	T	rs116840816		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:70443680G>T	uc004dzf.3	+	2	218	c.123G>T	c.(121-123)GAG>GAT	p.E41D	BCYRN1_uc011mpt.1_Intron|GJB1_uc004dzg.3_Missense_Mutation_p.E41D	NM_001097642	NP_001091111	P08034	CXB1_HUMAN	gap junction protein, beta 1, 32kDa	41	Helical; (Probable).		E -> K (in CMTX1).		cell-cell signaling|cellular membrane organization|gap junction assembly|nervous system development	connexon complex|endoplasmic reticulum membrane|integral to membrane	gap junction channel activity			breast(1)	1	Renal(35;0.156)					TGGCTGCAGAGAGTGTGTGGG	0.532			NA											34	63					1.16512e-39	1.94788e-39	0.006999	1	0
NHSL2	340527	broad.mit.edu	37	X	71360426	71360426	+	Missense_Mutation	SNP	G	G	T	rs140270842		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:71360426G>T	uc011mqa.1	+	6	3028	c.3028G>T	c.(3028-3030)GTG>TTG	p.V1010L	NHSL2_uc004eak.1_Missense_Mutation_p.V644L|NHSL2_uc010nli.2_Missense_Mutation_p.V779L	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	1010											0	Renal(35;0.156)					AAAACCCAGCGTGCTGTACCT	0.532			NA											8	17					0.00621372	0.00647137	0.006214	1	0
UPRT	139596	broad.mit.edu	37	X	74520800	74520800	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:74520800G>T	uc004ecb.1	+	6	952	c.823G>T	c.(823-825)GGT>TGT	p.G275C	UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.G275C|UPRT_uc004ece.1_Missense_Mutation_p.G139C	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	275					nucleoside metabolic process	cytoplasm|nucleus					0						CACTCCTCATGGTGAGTTCAG	0.423			NA											6	212					2.7689e-08	3.25752e-08	0.001984	1	0
TBX22	50945	broad.mit.edu	37	X	79277847	79277847	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:79277847C>A	uc010nmg.1	+	2	213	c.79C>A	c.(79-81)CCA>ACA	p.P27T	TBX22_uc004edi.1_5'UTR|TBX22_uc004edj.1_Missense_Mutation_p.P27T	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	27					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						ACTCCAAGACCCAATACAGGC	0.607			NA											10	16					1.76689e-08	2.0878e-08	0.006214	1	0
BRWD3	254065	broad.mit.edu	37	X	79936970	79936970	+	Silent	SNP	T	T	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:79936970T>C	uc004edt.2	-	40	4787	c.4524A>G	c.(4522-4524)CTA>CTG	p.L1508L	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Silent_p.L1104L|BRWD3_uc004edp.2_Silent_p.L1337L|BRWD3_uc004edq.2_Silent_p.L1104L|BRWD3_uc010nmj.1_Silent_p.L1104L|BRWD3_uc004edr.2_Silent_p.L1178L|BRWD3_uc004eds.2_Silent_p.L1104L|BRWD3_uc004edu.2_Silent_p.L1178L|BRWD3_uc004edv.2_Silent_p.L1104L|BRWD3_uc004edw.2_Silent_p.L1104L|BRWD3_uc004edx.2_Silent_p.L1104L|BRWD3_uc004edy.2_Silent_p.L1104L|BRWD3_uc004edz.2_Silent_p.L1178L|BRWD3_uc004eea.2_Silent_p.L1178L|BRWD3_uc004eeb.2_Silent_p.L1104L	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1508										ovary(4)	4						CAAGTAGATATAGTGAAAGCC	0.378			NA											72	80					0	0	0.00361	0	0
DACH2	117154	broad.mit.edu	37	X	85404014	85404014	+	Silent	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:85404014C>A	uc004eew.2	+	1	560	c.390C>A	c.(388-390)ATC>ATA	p.I130I	DACH2_uc004eex.2_Silent_p.I130I|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	130	DACHbox-N.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						AGGTCCGGATCCTCCGCGGGC	0.552			NA											7	23					7.48243e-07	8.5877e-07	0.006214	1	0
TRMT2B	79979	broad.mit.edu	37	X	100278506	100278506	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:100278506C>T	uc004egq.2	-	7	1008	c.709G>A	c.(709-711)GGG>AGG	p.G237R	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.G237R|TRMT2B_uc004egs.2_Missense_Mutation_p.G237R|TRMT2B_uc004egt.2_Missense_Mutation_p.G237R|TRMT2B_uc004egu.2_Missense_Mutation_p.G118R|TRMT2B_uc004egv.2_Missense_Mutation_p.G192R	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	237							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						ATTGTGTGCCCTTGGCTATTG	0.443			NA											93	139					0	0	0.00361	0	0
TEX13B	56156	broad.mit.edu	37	X	107224574	107224574	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:107224574G>A	uc004enn.1	-	3	768	c.675C>T	c.(673-675)CTC>CTT	p.L225L		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	225										ovary(1)	1						CAATAGCTCCGAGGGGCTGCC	0.592			NA											20	125					0	0	0.007413	0	0
TEX13B	56156	broad.mit.edu	37	X	107225113	107225113	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:107225113T>A	uc004enn.1	-	2	338	c.245A>T	c.(244-246)CAG>CTG	p.Q82L		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	82										ovary(1)	1						TAACTGCCCCTGCCTGTGGGC	0.617			NA											48	71					0	0	0.00361	0	0
GUCY2F	2986	broad.mit.edu	37	X	108628501	108628501	+	Silent	SNP	A	A	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:108628501A>C	uc004eod.3	-	16	3243	c.2967T>G	c.(2965-2967)GTT>GTG	p.V989V	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	989	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CCACTCCAGCAACAACCGGCC	0.478			NA											4	99					0	0	0.006122	0	0
CXorf61	203413	broad.mit.edu	37	X	115593113	115593113	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:115593113G>T	uc004eqj.1	-	2	257	c.137C>A	c.(136-138)TCT>TAT	p.S46Y		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	46	Extracellular (Potential).					integral to membrane|plasma membrane					0						AATTAACCCAGAAGAAGAGGG	0.398			NA											163	169					1.31883e-95	2.52095e-95	0.00361	1	0
LONRF3	79836	broad.mit.edu	37	X	118147138	118147138	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:118147138G>T	uc004eqw.2	+	9	1979	c.1948G>T	c.(1948-1950)GAC>TAC	p.D650Y	LONRF3_uc004eqx.2_Missense_Mutation_p.D609Y|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.D394Y	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	650	Lon.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						CAACACAGCCGACATTGAATA	0.488			NA											25	46					1.55811e-20	2.24667e-20	0.008361	1	0
ATP1B4	23439	broad.mit.edu	37	X	119512560	119512560	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:119512560A>G	uc004esr.2	+	7	928	c.844A>G	c.(844-846)ATC>GTC	p.I282V	ATP1B4_uc004esq.2_Missense_Mutation_p.I278V|ATP1B4_uc011mtx.1_Missense_Mutation_p.I247V|ATP1B4_uc011mty.1_Missense_Mutation_p.I239V	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	282	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						CATCCGATCCATCAGTTACTA	0.478			NA											107	184					0	0	0.00361	0	0
STAG2	10735	broad.mit.edu	37	X	123156495	123156495	+	Missense_Mutation	SNP	A	A	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:123156495A>T	uc004etz.3	+	2	357	c.18A>T	c.(16-18)GAA>GAT	p.E6D	STAG2_uc004eua.2_Missense_Mutation_p.E6D|STAG2_uc004eub.2_Missense_Mutation_p.E6D|STAG2_uc004euc.2_Missense_Mutation_p.E6D|STAG2_uc004eud.2_Missense_Mutation_p.E6D|STAG2_uc004eue.2_Missense_Mutation_p.E6D	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	6					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAGCTCCAGAAATACCAACTG	0.308			NA											17	16					0	0	0.010504	0	0
FHL1	2273	broad.mit.edu	37	X	135288623	135288623	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:135288623G>T	uc004ezo.2	+	2	132	c.32G>T	c.(31-33)AGG>ATG	p.R11M	FHL1_uc010nrz.2_Missense_Mutation_p.R11M|FHL1_uc004ezm.2_RNA|FHL1_uc004ezl.2_Missense_Mutation_p.R11M|FHL1_uc004ezq.2_Missense_Mutation_p.R11M|FHL1_uc011mvy.1_Missense_Mutation_p.R11M|FHL1_uc011mvz.1_Missense_Mutation_p.R11M|FHL1_uc004ezn.2_Missense_Mutation_p.R11M|FHL1_uc011mwa.1_Missense_Mutation_p.R40M|FHL1_uc011mwb.1_RNA|FHL1_uc004ezp.2_Missense_Mutation_p.R27M|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	11	C4-type (Potential).				cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					CACTACTGCAGGGATCCCTTG	0.557			NA											117	179					1.21703e-59	2.20166e-59	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135429796	135429796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:135429796C>T	uc004ezu.1	+	6	4222	c.3931C>T	c.(3931-3933)CAA>TAA	p.Q1311*	GPR112_uc010nsb.1_Nonsense_Mutation_p.Q1106*|GPR112_uc010nsc.1_Nonsense_Mutation_p.Q1078*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1311	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTCCAGTCACCAAACACATTC	0.443			NA											132	206					0	0	0.00361	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995285	140995285	+	Missense_Mutation	SNP	C	C	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:140995285C>A	uc004fbt.2	+	4	2381	c.2095C>A	c.(2095-2097)CTT>ATT	p.L699I	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	699							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGAGTCCTCTTGAGGGAGA	0.562			NA								HNSCC(15;0.026)			23	30					3.28513e-13	4.25412e-13	0.003954	1	0
AFF2	2334	broad.mit.edu	37	X	147743879	147743879	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:147743879G>T	uc004fcp.2	+	3	1110	c.631G>T	c.(631-633)GAG>TAG	p.E211*	AFF2_uc004fco.2_Nonsense_Mutation_p.E207*|AFF2_uc004fcq.2_Nonsense_Mutation_p.E207*|AFF2_uc004fcr.2_Nonsense_Mutation_p.E207*|AFF2_uc011mxb.1_Nonsense_Mutation_p.E211*|AFF2_uc004fcs.2_Nonsense_Mutation_p.E207*	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	211					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAGTTGAAGAGTCAAACCC	0.433			NA											183	258					2.40723e-144	4.65915e-144	0.00361	1	0
GABRE	2564	broad.mit.edu	37	X	151131077	151131077	+	Silent	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:151131077G>A	uc004ffi.2	-	4	435	c.381C>T	c.(379-381)TAC>TAT	p.Y127Y	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	127	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGCGTTCGTCGTACCAGGTCT	0.463			NA											11	209					0	0	0.00245	0	0
ATP2B3	492	broad.mit.edu	37	X	152814180	152814180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:152814180G>A	uc004fht.1	+	8	1332	c.1206G>A	c.(1204-1206)TGG>TGA	p.W402*	ATP2B3_uc004fhs.1_Nonsense_Mutation_p.W402*	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	402	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCGGACATGGCTGGCAGAGT	0.562			NA											7	50					0	0	0.006214	0	0
F8	2157	broad.mit.edu	37	X	154157069	154157069	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:154157069G>A	uc004fmt.2	-	14	5167	c.4996C>T	c.(4996-4998)CAA>TAA	p.Q1666*		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1666	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATTTCCCGTTGATGGCGTTTC	0.408			NA											24	341					0	0	0.003954	0	0
RAB39B	116442	broad.mit.edu	37	X	154490316	154490316	+	Silent	SNP	G	G	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:154490316G>T	uc004fne.2	-	2	693	c.414C>A	c.(412-414)GCC>GCA	p.A138A		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	138					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCAGTTTCTCGGCCTCGTGGC	0.488			NA											73	110					3.80779e-57	6.81993e-57	0.00361	1	0
RERE	473	broad.mit.edu	37	1	8716109	8716109	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:8716109delT	uc001ape.2	-	3	1058	c.248delA	c.(247-249)AAGfs	p.K83fs	RERE_uc001apf.2_Frame_Shift_Del_p.K83fs|RERE_uc001aph.1_Frame_Shift_Del_p.K83fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	83					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		ATAACGAGACTTTTTTTTCGG	0.453			NA											8	1345	---	---	---	---	NA	NA	NA	NA	NA
MST1P9	11223	broad.mit.edu	37	1	17085406	17085407	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:17085406_17085407insG	uc010ock.1	-	10	1284_1285	c.1284_1285insC	c.(1282-1287)TGCACAfs	p.C428fs	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CCTCCAGTTGTGCATGCGGTTC	0.579			NA											8	83	---	---	---	---	NA	NA	NA	NA	NA
PUM1	9698	broad.mit.edu	37	1	31406073	31406074	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:31406073_31406074insG	uc001bsi.1	-	22	3658_3659	c.3545_3546insC	c.(3544-3546)CCTfs	p.P1182fs	PUM1_uc001bsf.1_Frame_Shift_Ins_p.P850fs|PUM1_uc001bsg.1_Frame_Shift_Ins_p.P916fs|PUM1_uc001bsh.1_Frame_Shift_Ins_p.P1184fs|PUM1_uc001bsj.1_Frame_Shift_Ins_p.P1158fs|PUM1_uc010oga.1_Frame_Shift_Ins_p.P1040fs|PUM1_uc001bsk.1_Frame_Shift_Ins_p.P1220fs|PUM1_uc010ogb.1_Frame_Shift_Ins_p.P1123fs	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1182					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGATACCATTAGGGGGGCCACA	0.525			NA											7	610	---	---	---	---	NA	NA	NA	NA	NA
KHDRBS1	10657	broad.mit.edu	37	1	32503458	32503459	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:32503458_32503459insG	uc001bub.2	+	6	1034_1035	c.928_929insG	c.(928-930)CGGfs	p.R310fs	KHDRBS1_uc001bua.1_Frame_Shift_Ins_p.R271fs|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	310	Arg/Gly-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGGACCACCTCGGGGGGCTTTG	0.5	Ovarian(173;401 1982 12359 31110 42403)		NA											8	285	---	---	---	---	NA	NA	NA	NA	NA
ZBTB8A	653121	broad.mit.edu	37	1	33065979	33065981	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:33065979_33065981delGAA	uc001bvn.2	+	5	1770_1772	c.1285_1287delGAA	c.(1285-1287)GAAdel	p.E433del	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_3'UTR|ZBTB8OS_uc001bvo.1_Intron	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	433	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGATGATAGTGAAGAAGAAGAAG	0.414			NA											7	333	---	---	---	---	NA	NA	NA	NA	NA
RNF19B	127544	broad.mit.edu	37	1	33402697	33402698	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:33402697_33402698insG	uc010oho.1	-	9	1908_1909	c.1908_1909insC	c.(1906-1911)CCCTGCfs	p.P636fs	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Frame_Shift_Ins_p.P635fs	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	636_637						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGGTGTCTGCAGGGGGGATCCT	0.559			NA											12	458	---	---	---	---	NA	NA	NA	NA	NA
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:36935322_36935323insG	uc001caw.1	-	11	1582_1583	c.1404_1405insC	c.(1402-1407)CCCAGCfs	p.P468fs	CSF3R_uc001cat.1_Frame_Shift_Ins_p.P31fs|CSF3R_uc009vvc.1_Frame_Shift_Ins_p.P31fs|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Frame_Shift_Ins_p.P468fs|CSF3R_uc001cax.1_Frame_Shift_Ins_p.P468fs|CSF3R_uc001cay.1_Frame_Shift_Ins_p.P468fs	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	468_469	Extracellular (Potential).|Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634			NA											10	181	---	---	---	---	NA	NA	NA	NA	NA
HIVEP3	59269	broad.mit.edu	37	1	42048867	42048868	+	Frame_Shift_Ins	INS	-	-	G	rs151333512		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:42048867_42048868insG	uc001cgz.3	-	4	2814_2815	c.1601_1602insC	c.(1600-1602)CCTfs	p.P534fs	HIVEP3_uc001cha.3_Frame_Shift_Ins_p.P534fs|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	534	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAGAGGCACAGGGGGGGCGGT	0.594			NA											7	111	---	---	---	---	NA	NA	NA	NA	NA
ZMYND12	84217	broad.mit.edu	37	1	42898878	42898879	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:42898878_42898879insG	uc001chj.2	-	7	1180_1181	c.910_911insC	c.(910-912)CAAfs	p.Q304fs	ZMYND12_uc010ojt.1_Frame_Shift_Ins_p.Q194fs	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	304						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATGGTTTTTTGGGGGGCTTTG	0.411			NA											13	528	---	---	---	---	NA	NA	NA	NA	NA
KIAA0467	23334	broad.mit.edu	37	1	43896326	43896327	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:43896326_43896327insG	uc001cjk.1	+	17	2405_2406	c.1943_1944insG	c.(1942-1944)TTGfs	p.L648fs		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1547						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCAGTATCTTGGGGGGCGACT	0.609			NA											7	378	---	---	---	---	NA	NA	NA	NA	NA
KDM4A	9682	broad.mit.edu	37	1	44156564	44156565	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:44156564_44156565insC	uc001cjx.2	+	14	2252_2253	c.2086_2087insC	c.(2086-2088)GCCfs	p.A696fs	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	696					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TTCAGATTTAGCCCCCCAGAAG	0.47			NA											9	647	---	---	---	---	NA	NA	NA	NA	NA
PIK3R3	8503	broad.mit.edu	37	1	46546323	46546324	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:46546323_46546324insC	uc001cpb.3	-	2	961_962	c.205_206insG	c.(205-207)GATfs	p.D69fs	PIK3R3_uc009vyb.2_Frame_Shift_Ins_p.D69fs|PIK3R3_uc009vyc.2_Frame_Shift_Ins_p.D86fs|PIK3R3_uc001cpc.3_Frame_Shift_Ins_p.D69fs|PIK3R3_uc010olw.1_Frame_Shift_Ins_p.D115fs	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	69	SH2 1.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CCTTGAAATATCCCCCCAGTAC	0.351			NA											10	1160	---	---	---	---	NA	NA	NA	NA	NA
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:55081756_55081757insG	uc001cxn.2	-	3	483_484	c.351_352insC	c.(349-354)CCCACTfs	p.P117fs	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	117_118						integral to membrane					0						CTGTAGATAGTGGGGGGGTGTG	0.594			NA											18	262	---	---	---	---	NA	NA	NA	NA	NA
FGGY	55277	broad.mit.edu	37	1	59812016	59812017	+	Frame_Shift_Ins	INS	-	-	G	rs145440779	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:59812016_59812017insG	uc001czi.3	+	4	623_624	c.411_412insG	c.(409-414)GTCGGGfs	p.V137fs	FGGY_uc001czg.2_Frame_Shift_Ins_p.V25fs|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Frame_Shift_Ins_p.V137fs|FGGY_uc001czj.3_Frame_Shift_Ins_p.V137fs|FGGY_uc001czk.3_Frame_Shift_Ins_p.V25fs|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	137_138					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TCCAGTACGTCGGGGGGGTGAT	0.5			NA											14	345	---	---	---	---	NA	NA	NA	NA	NA
JAK1	3716	broad.mit.edu	37	1	65325832	65325833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:65325832_65325833insG	uc001dbu.1	-	9	1538_1539	c.1289_1290insC	c.(1288-1290)CCGfs	p.P430fs	JAK1_uc009wam.1_Frame_Shift_Ins_p.P418fs	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	430					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.P430fs*2(1)		haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGACGATCAACGGGGGGGCCAC	0.54			NA	Mis		ALL								9	272	---	---	---	---	NA	NA	NA	NA	NA
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:74575212_74575213insT	uc001dfy.3	-	5	924_925	c.732_733insA	c.(730-735)AAACAGfs	p.K244fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	244_245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						ovary(2)	2						TTTTCCTGCTGTTTTTTTTTGT	0.327			NA											9	140	---	---	---	---	NA	NA	NA	NA	NA
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:89613321_89613322insC	uc001dna.2	-	8	1432_1433	c.1293_1294insG	c.(1291-1296)GGGCACfs	p.G431fs	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	431_432						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436			NA											17	200	---	---	---	---	NA	NA	NA	NA	NA
C1orf183	55924	broad.mit.edu	37	1	112269924	112269925	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:112269924_112269925insC	uc001ebo.1	-	2	717_718	c.559_560insG	c.(559-561)GCAfs	p.A187fs	C1orf183_uc001ebp.1_Frame_Shift_Ins_p.A172fs	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	187										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		GGGTTCACGTGCCCCCCCAGTC	0.579			NA											10	200	---	---	---	---	NA	NA	NA	NA	NA
SPAG17	200162	broad.mit.edu	37	1	118583386	118583387	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:118583386_118583387insC	uc001ehk.2	-	22	3200_3201	c.3132_3133insG	c.(3130-3135)GGGCAGfs	p.G1044fs		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1044_1045						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACTTCAATCTGCCCCCCATCAG	0.371			NA											7	371	---	---	---	---	NA	NA	NA	NA	NA
NBPF7	343505	broad.mit.edu	37	1	120379931	120379932	+	Frame_Shift_Ins	INS	-	-	G	rs115348036	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:120379931_120379932insG	uc010oxk.1	-	6	1510_1511	c.889_890insC	c.(889-891)CAGfs	p.Q297fs		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	297	NBPF 2.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		CAGAGTTACCTGGGGGGGCACT	0.446			NA											7	185	---	---	---	---	NA	NA	NA	NA	NA
LOC647121	647121	broad.mit.edu	37	1	121309960	121309961	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:121309960_121309961insA	uc009wht.1	+	3	338_339	c.309_310insA	c.(307-312)AGCAATfs	p.S103fs	LOC647121_uc001eiu.1_RNA					Homo sapiens cDNA FLJ46881 fis, clone UTERU3015647, moderately similar to Embigin precursor.												0						CAGATGATAGCAATGGTATAGA	0.277			NA											15	63	---	---	---	---	NA	NA	NA	NA	NA
ITGA10	8515	broad.mit.edu	37	1	145534121	145534122	+	Frame_Shift_Ins	INS	-	-	C	rs147270843		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:145534121_145534122insC	uc001eoa.2	+	14	1702_1703	c.1626_1627insC	c.(1624-1629)GAACCCfs	p.E542fs	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Frame_Shift_Ins_p.E411fs|ITGA10_uc009wiw.2_Frame_Shift_Ins_p.E399fs|ITGA10_uc010oyw.1_Frame_Shift_Ins_p.E487fs	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	542_543	Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCAGCCAGAACCCCCCCAGGA	0.554			NA											16	443	---	---	---	---	NA	NA	NA	NA	NA
PIAS3	10401	broad.mit.edu	37	1	145579284	145579285	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:145579284_145579285insC	uc001eoc.1	+	5	712_713	c.621_622insC	c.(619-624)TTTCCCfs	p.F207fs	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_Frame_Shift_Ins_p.F198fs|PIAS3_uc001eod.1_5'Flank	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	207_208	PINIT.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGATTATTTTCCCCCCAACCT	0.465			NA											7	229	---	---	---	---	NA	NA	NA	NA	NA
PIAS3	10401	broad.mit.edu	37	1	145584022	145584023	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:145584022_145584023insC	uc001eoc.1	+	10	1344_1345	c.1253_1254insC	c.(1252-1254)TGCfs	p.C418fs	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Frame_Shift_Ins_p.C87fs	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	418					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCTGAGGTTTGCCCCCCGCCAG	0.5			NA											12	551	---	---	---	---	NA	NA	NA	NA	NA
BCL9	607	broad.mit.edu	37	1	147090981	147090982	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:147090981_147090982insC	uc001epq.2	+	8	1760_1761	c.1020_1021insC	c.(1018-1023)GAGCCCfs	p.E340fs	BCL9_uc010ozr.1_Frame_Shift_Ins_p.E266fs	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	340_341	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CCAGTGGCGAGCCCCCCACACT	0.589			NA	T	IGH@|IGL@	B-ALL								7	211	---	---	---	---	NA	NA	NA	NA	NA
BCL9	607	broad.mit.edu	37	1	147092680	147092681	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:147092680_147092681insC	uc001epq.2	+	8	3459_3460	c.2719_2720insC	c.(2719-2721)TCCfs	p.S907fs	BCL9_uc010ozr.1_Frame_Shift_Ins_p.S833fs	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	907	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TTCCATTAAGTCCCCCCCTGTT	0.619			NA	T	IGH@|IGL@	B-ALL								8	204	---	---	---	---	NA	NA	NA	NA	NA
CELF3	11189	broad.mit.edu	37	1	151680126	151680127	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:151680126_151680127insG	uc001eys.1	-	7	1425	c.631_splice	c.e7-1	p.L211_splice	CELF3_uc010pdh.1_Splice_Site_p.L19_splice|CELF3_uc001eyr.2_Splice_Site_p.L210_splice|CELF3_uc009wmy.2_Splice_Site_p.L211_splice|CELF3_uc009wmx.1_Splice_Site_p.L211_splice|CELF3_uc001eyt.2_Intron|C1orf230_uc001eyu.2_5'Flank	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4						nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						CTGCATCAGCTGGGGGGAGGGG	0.693			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
HAX1	10456	broad.mit.edu	37	1	154246356	154246357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:154246356_154246357insG	uc001fes.2	+	3	584_585	c.423_424insG	c.(421-426)TTTGGGfs	p.F141fs	HAX1_uc001fet.2_Frame_Shift_Ins_p.F93fs|HAX1_uc010peo.1_Frame_Shift_Ins_p.F149fs|HAX1_uc009wou.2_Frame_Shift_Ins_p.F66fs|HAX1_uc009wov.2_Frame_Shift_Ins_p.F115fs	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	141_142	Involved in HCLS1 binding.					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCAGGATCTTTGGGGGGGTCTT	0.554			NA							Kostmann_syndrome				7	244	---	---	---	---	NA	NA	NA	NA	NA
MRPL24	79590	broad.mit.edu	37	1	156708444	156708445	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:156708444_156708445insG	uc001fpw.1	-	2	191_192	c.52_53insC	c.(52-54)CATfs	p.H18fs	MRPL24_uc001fpx.1_Frame_Shift_Ins_p.H18fs	NM_024540	NP_078816	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24 precursor	18					translation	mitochondrion|ribosome	structural constituent of ribosome				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATAGCGGTAATGGGGGGGCAGA	0.574			NA											9	81	---	---	---	---	NA	NA	NA	NA	NA
PRCC	5546	broad.mit.edu	37	1	156761535	156761536	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:156761535_156761536insC	uc001fqa.2	+	4	1420_1421	c.1130_1131insC	c.(1129-1131)GTCfs	p.V377fs	PRCC_uc001fqb.2_Intron	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	377					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGGCCCTGGTCCCCCCCCAGG	0.53			NA	T	TFE3	papillary renal 								22	252	---	---	---	---	NA	NA	NA	NA	NA
OR10Z1	128368	broad.mit.edu	37	1	158576486	158576487	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:158576486_158576487insG	uc010pio.1	+	1	258_259	c.258_259insG	c.(256-261)GCTGGGfs	p.A86fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	86_87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTGGCCTGGCTGGGGGGGACCA	0.554			NA											39	1371	---	---	---	---	NA	NA	NA	NA	NA
OR10Z1	128368	broad.mit.edu	37	1	158577072	158577073	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:158577072_158577073insC	uc010pio.1	+	1	844_845	c.844_845insC	c.(844-846)ACCfs	p.T282fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TACTGTAGTGACCCCCCTCCTT	0.46			NA											12	2020	---	---	---	---	NA	NA	NA	NA	NA
KCNJ10	3766	broad.mit.edu	37	1	160012017	160012018	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:160012017_160012018insG	uc001fuw.1	-	2	455_456	c.305_306insC	c.(304-306)CCGfs	p.P102fs		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	102	Extracellular (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTGGTTGGCCGGGGGGTCCAG	0.584	GBM(167;1368 2014 14817 36425 43215)		NA											7	535	---	---	---	---	NA	NA	NA	NA	NA
VANGL2	57216	broad.mit.edu	37	1	160388801	160388802	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:160388801_160388802insG	uc001fwb.1	+	5	501_502	c.202_203insG	c.(202-204)TGGfs	p.W68fs	VANGL2_uc001fwc.1_Frame_Shift_Ins_p.W68fs	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	68	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGATGACAACTGGGGGGAAACG	0.406			NA											11	597	---	---	---	---	NA	NA	NA	NA	NA
SLAMF1	6504	broad.mit.edu	37	1	160593935	160593936	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:160593935_160593936insC	uc001fwl.3	-	4	1086_1087	c.740_741insG	c.(739-741)GGTfs	p.G247fs	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_Intron	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	247	Helical; (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCATGATGACACCCCCTAACAG	0.391			NA											8	2330	---	---	---	---	NA	NA	NA	NA	NA
ADCY10	55811	broad.mit.edu	37	1	167865905	167865906	+	Frame_Shift_Ins	INS	-	-	G	rs35604923		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:167865905_167865906insG	uc001ger.2	-	7	964_965	c.666_667insC	c.(664-669)CCCAATfs	p.P222fs	ADCY10_uc009wvk.2_Frame_Shift_Ins_p.P130fs|ADCY10_uc010plj.1_Frame_Shift_Ins_p.P69fs|ADCY10_uc009wvl.2_Frame_Shift_Ins_p.P221fs|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	222_223					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAATTAAAATTGGGGGGTGGTT	0.332			NA											10	613	---	---	---	---	NA	NA	NA	NA	NA
ABL2	27	broad.mit.edu	37	1	179078403	179078404	+	Frame_Shift_Ins	INS	-	-	G	rs138240636	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:179078403_179078404insG	uc001gmj.3	-	12	2285_2286	c.1998_1999insC	c.(1996-2001)CCCAAAfs	p.P666fs	ABL2_uc010pnf.1_Frame_Shift_Ins_p.P666fs|ABL2_uc010png.1_Frame_Shift_Ins_p.P645fs|ABL2_uc010pnh.1_Frame_Shift_Ins_p.P645fs|ABL2_uc001gmg.3_Frame_Shift_Ins_p.P651fs|ABL2_uc001gmi.3_Frame_Shift_Ins_p.P651fs|ABL2_uc001gmh.3_Frame_Shift_Ins_p.P630fs|ABL2_uc010pne.1_Frame_Shift_Ins_p.P630fs	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	666_667					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CTGCTGCGTTTGGGGGGTGTAG	0.505			NA	T	ETV6	AML								7	461	---	---	---	---	NA	NA	NA	NA	NA
FAM129A	116496	broad.mit.edu	37	1	184764537	184764538	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:184764537_184764538insC	uc001gra.2	-	14	2554_2555	c.2360_2361insG	c.(2359-2361)GGAfs	p.G787fs	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	787	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						CCTCTGGAAATCCCCCCAACTC	0.668			NA											8	542	---	---	---	---	NA	NA	NA	NA	NA
KIF21B	23046	broad.mit.edu	37	1	200956270	200956271	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:200956270_200956271insG	uc001gvs.1	-	25	3784_3785	c.3467_3468insC	c.(3466-3468)CCAfs	p.P1156fs	KIF21B_uc001gvr.1_Frame_Shift_Ins_p.P1156fs|KIF21B_uc009wzl.1_Frame_Shift_Ins_p.P1156fs|KIF21B_uc010ppn.1_Frame_Shift_Ins_p.P1156fs	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1156					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						AGATATCCAGTGGGGGGCCCAG	0.559			NA											12	435	---	---	---	---	NA	NA	NA	NA	NA
CACNA1S	779	broad.mit.edu	37	1	201035446	201035447	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:201035446_201035447insG	uc001gvv.2	-	21	2885	c.2658_splice	c.e21-1	p.E886_splice		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCACTGGACCTGGGGGGCGGCA	0.644			NA											9	215	---	---	---	---	NA	NA	NA	NA	NA
CACNA1S	779	broad.mit.edu	37	1	201046125	201046126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:201046125_201046126insC	uc001gvv.2	-	12	1976_1977	c.1749_1750insG	c.(1747-1752)GGGAGGfs	p.G583fs		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	583_584	II.|Extracellular (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTCATACCTCCCCCCAAAGA	0.441			NA											11	356	---	---	---	---	NA	NA	NA	NA	NA
NAV1	89796	broad.mit.edu	37	1	201779175	201779176	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:201779175_201779176insC	uc001gwu.2	+	22	4841_4842	c.4494_4495insC	c.(4492-4497)GAGCCCfs	p.E1498fs	NAV1_uc001gwx.2_Frame_Shift_Ins_p.E1107fs	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1501_1502					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TGGATGCAGAGCCCCCCGAGAT	0.525			NA											7	451	---	---	---	---	NA	NA	NA	NA	NA
ATP2B4	493	broad.mit.edu	37	1	203667345	203667346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:203667345_203667346insC	uc001gzw.2	+	3	1138_1139	c.254_255insC	c.(253-255)ATCfs	p.I85fs	ATP2B4_uc001gzv.2_Frame_Shift_Ins_p.I85fs|ATP2B4_uc009xaq.2_Frame_Shift_Ins_p.I85fs	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	85	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACAACGTGATCCCCCCCAAAA	0.48			NA											7	276	---	---	---	---	NA	NA	NA	NA	NA
TMEM81	388730	broad.mit.edu	37	1	205052693	205052694	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:205052693_205052694insC	uc001hbt.2	-	1	895_896	c.755_756insG	c.(754-756)GGCfs	p.G252fs		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	252	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ACTGCTGCAGGCCCCCCCTTAG	0.54			NA											11	414	---	---	---	---	NA	NA	NA	NA	NA
CR2	1380	broad.mit.edu	37	1	207642043	207642044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:207642043_207642044insC	uc001hfw.2	+	3	711_712	c.617_618insC	c.(616-618)GTCfs	p.V206fs	CR2_uc001hfv.2_Frame_Shift_Ins_p.V206fs|CR2_uc009xch.2_Frame_Shift_Ins_p.V206fs|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	206	Sushi 3.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TGGAGTGCTGTCCCCCCCACAT	0.396			NA											13	601	---	---	---	---	NA	NA	NA	NA	NA
USH2A	7399	broad.mit.edu	37	1	215821895	215821896	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:215821895_215821896insG	uc001hku.1	-	66	14943_14944	c.14556_14557insC	c.(14554-14559)CCCATGfs	p.P4852fs		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4852_4853	Extracellular (Potential).|Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGGGGAACATGGGGGGACTCC	0.51			NA								HNSCC(13;0.011)			8	692	---	---	---	---	NA	NA	NA	NA	NA
RAB3GAP2	25782	broad.mit.edu	37	1	220406172	220406172	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:220406172delC	uc010puk.1	-	2	313	c.149delG	c.(148-150)GGAfs	p.G50fs	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_5'UTR|RAB3GAP2_uc010pum.1_Frame_Shift_Del_p.G50fs	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	50					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		TTCCCATGCTCCCCAACCATC	0.328			NA											66	177	---	---	---	---	NA	NA	NA	NA	NA
MIXL1	83881	broad.mit.edu	37	1	226413314	226413314	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:226413314delA	uc010pvm.1	+	2	500	c.500delA	c.(499-501)GAAfs	p.E167fs		NM_031944	NP_114150	Q9H2W2	MIXL1_HUMAN	Mix-like homeobox protein 1	167					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		CCTGGAACTGAAACGAAATGT	0.552	Pancreas(72;1302 1881 20981 22800)		NA											21	82	---	---	---	---	NA	NA	NA	NA	NA
TARBP1	6894	broad.mit.edu	37	1	234556531	234556532	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:234556531_234556532insT	uc001hwd.2	-	21	3471_3472	c.3471_3472insA	c.(3469-3474)AAACGCfs	p.K1157fs		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1157_1158					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			ACATAGTAGCGTTTTTTGGACT	0.366			NA											7	907	---	---	---	---	NA	NA	NA	NA	NA
VN1R5	317705	broad.mit.edu	37	1	247419937	247419938	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr1:247419937_247419938insC	uc010pyu.1	+	2	564_565	c.564_565insC	c.(562-567)CTACCCfs	p.L188fs		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	188_189	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			CACTGCGGCTACCCCCAGTGAA	0.46	GBM(98;63 1399 4825 21305 33017)		NA											7	1319	---	---	---	---	NA	NA	NA	NA	NA
CUBN	8029	broad.mit.edu	37	10	16877089	16877090	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:16877089_16877090insG	uc001ioo.2	-	64	10337_10338	c.10285_10286insC	c.(10285-10287)CAGfs	p.Q3429fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3429	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGTGTGGTTCTGGGGGGCTGTG	0.45			NA											10	536	---	---	---	---	NA	NA	NA	NA	NA
PIP4K2A	5305	broad.mit.edu	37	10	22830827	22830828	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:22830827_22830828insG	uc001irl.3	-	8	1189_1190	c.941_942insC	c.(940-942)CCAfs	p.P314fs	PIP4K2A_uc010qcu.1_Frame_Shift_Ins_p.P174fs	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	314	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						CGGGGCTATCTGGGGGGGTTCC	0.584			NA											7	133	---	---	---	---	NA	NA	NA	NA	NA
ANKRD26	22852	broad.mit.edu	37	10	27322258	27322259	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:27322258_27322259insT	uc001ith.2	-	25	3871_3872	c.3699_3700insA	c.(3697-3702)AAACAAfs	p.K1233fs	ANKRD26_uc001itg.2_Frame_Shift_Ins_p.K920fs|ANKRD26_uc009xku.1_Frame_Shift_Ins_p.K1234fs	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1233_1234	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GACATAGATTGTTTTTTTAGGG	0.312			NA											7	749	---	---	---	---	NA	NA	NA	NA	NA
ZNF248	57209	broad.mit.edu	37	10	38121236	38121237	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:38121236_38121237insC	uc001izd.1	-	6	1545_1546	c.1046_1047insG	c.(1045-1047)GGAfs	p.G349fs	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Frame_Shift_Ins_p.G349fs	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATAAGACTTTCCCCCCATGTG	0.401			NA											7	569	---	---	---	---	NA	NA	NA	NA	NA
FAM21B	55747	broad.mit.edu	37	10	47909192	47909193	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:47909192_47909193insC	uc009xni.2	+	10	762_763	c.762_763insC	c.(760-765)ACACCCfs	p.T254fs	FAM21B_uc001jep.3_Frame_Shift_Ins_p.T149fs	NM_018232	NP_060702	Q5SNT6	FA21B_HUMAN	hypothetical protein LOC55747	254_255					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						ACTTATTCACACCCCCCAAGCT	0.515			NA											18	308	---	---	---	---	NA	NA	NA	NA	NA
CSTF2T	23283	broad.mit.edu	37	10	53458899	53458900	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:53458899_53458900insG	uc001jjp.2	-	1	456_457	c.410_411insC	c.(409-411)CCGfs	p.P137fs	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	137					mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		ACATCTGCTCCGGGGGGAGACT	0.515			NA											8	150	---	---	---	---	NA	NA	NA	NA	NA
RHOBTB1	9886	broad.mit.edu	37	10	62645896	62645897	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:62645896_62645897insC	uc001jli.2	-	8	1986_1987	c.1548_1549insG	c.(1546-1551)GGGTCAfs	p.G516fs	RHOBTB1_uc001jlh.2_Frame_Shift_Ins_p.G516fs|RHOBTB1_uc001jlj.2_Frame_Shift_Ins_p.G516fs|RHOBTB1_uc001jlk.2_Frame_Shift_Ins_p.G516fs|RHOBTB1_uc009xpe.1_Frame_Shift_Ins_p.G454fs|RHOBTB1_uc001jll.2_Frame_Shift_Ins_p.G266fs	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	516_517	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					TCCACAAATGACCCCCCGAACA	0.48			NA											8	595	---	---	---	---	NA	NA	NA	NA	NA
SEC24C	9632	broad.mit.edu	37	10	75525559	75525560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:75525559_75525560insC	uc001juw.2	+	11	1547_1548	c.1368_1369insC	c.(1366-1371)GTTCCCfs	p.V456fs	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Frame_Shift_Ins_p.V314fs|SEC24C_uc001jux.2_Frame_Shift_Ins_p.V456fs|SEC24C_uc010qko.1_Frame_Shift_Ins_p.V337fs|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	456_457					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					TTCCCACAGTTCCCCCCCAGTA	0.51			NA											17	472	---	---	---	---	NA	NA	NA	NA	NA
MYST4	23522	broad.mit.edu	37	10	76790222	76790223	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:76790222_76790223insC	uc001jwn.1	+	18	6133_6134	c.5640_5641insC	c.(5638-5643)CCACCCfs	p.P1880fs	MYST4_uc001jwo.1_Frame_Shift_Ins_p.P1588fs|MYST4_uc001jwp.1_Frame_Shift_Ins_p.P1697fs	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1880_1881	Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CCATGACCCCACCCCCCAACCT	0.535			NA	T	CREBBP	AML								21	344	---	---	---	---	NA	NA	NA	NA	NA
ZMIZ1	57178	broad.mit.edu	37	10	81072445	81072446	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:81072445_81072446insC	uc001kaf.2	+	25	3715_3716	c.3143_3144insC	c.(3142-3144)GACfs	p.D1048fs	ZMIZ1_uc001kag.2_Frame_Shift_Ins_p.D924fs|ZMIZ1_uc010qlq.1_Frame_Shift_Ins_p.D114fs	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	1048					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			TCTTATCTGGACCCCCCCGACC	0.559			NA											9	145	---	---	---	---	NA	NA	NA	NA	NA
HECTD2	143279	broad.mit.edu	37	10	93272060	93272061	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:93272060_93272061insC	uc001khl.2	+	21	2350_2351	c.2250_2251insC	c.(2248-2253)CTTCCCfs	p.L750fs	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Frame_Shift_Ins_p.L754fs|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_Frame_Shift_Ins_p.L339fs|HECTD2_uc001khn.1_Frame_Shift_Ins_p.L400fs	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	750_751	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						AACTTTGCCTTCCCCCCTACAA	0.356	NSCLC(12;376 469 1699 39910 41417)		NA											12	905	---	---	---	---	NA	NA	NA	NA	NA
MYOF	26509	broad.mit.edu	37	10	95169434	95169435	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:95169434_95169435insC	uc001kin.2	-	6	618_619	c.495_496insG	c.(493-498)GGGCCCfs	p.G165fs	MYOF_uc001kio.2_Frame_Shift_Ins_p.G165fs|MYOF_uc001kip.3_Frame_Shift_Ins_p.G165fs|MYOF_uc009xuf.2_Frame_Shift_Ins_p.G147fs	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	165_166	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GGCCCCTTGGGCCCAGGGCCCC	0.535			NA											68	1054	---	---	---	---	NA	NA	NA	NA	NA
TLL2	7093	broad.mit.edu	37	10	98164994	98164995	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:98164994_98164995insG	uc001kml.1	-	10	1487_1488	c.1261_1262insC	c.(1261-1263)CTTfs	p.L421fs	TLL2_uc009xvf.1_Frame_Shift_Ins_p.L399fs	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	421	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CTTACCCAAAAGGGGGGCTTTT	0.48			NA											11	792	---	---	---	---	NA	NA	NA	NA	NA
TLL2	7093	broad.mit.edu	37	10	98188503	98188504	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:98188503_98188504insC	uc001kml.1	-	5	748_749	c.522_523insG	c.(520-525)GGGAGCfs	p.G174fs	TLL2_uc009xvf.1_Frame_Shift_Ins_p.G122fs	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	174_175	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCCCTCTGGCTCCCTGAAACAA	0.371			NA											19	93	---	---	---	---	NA	NA	NA	NA	NA
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:98336475delT	uc001kmm.3	-	2	431	c.214delA	c.(214-216)AGTfs	p.S72fs	TM9SF3_uc010qot.1_Frame_Shift_Del_p.S72fs	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	72						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363			NA											7	376	---	---	---	---	NA	NA	NA	NA	NA
CUTC	51076	broad.mit.edu	37	10	101499503	101499504	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:101499503_101499504insG	uc001kqd.3	+	3	318_319	c.170_171insG	c.(169-171)GAGfs	p.E57fs	CUTC_uc010qpk.1_Frame_Shift_Ins_p.E57fs|CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	57					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		GGTTTATCAGAGGGGGGAACTA	0.401			NA											9	501	---	---	---	---	NA	NA	NA	NA	NA
CPN1	1369	broad.mit.edu	37	10	101816832	101816833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:101816832_101816833insG	uc001kql.2	-	6	1208_1209	c.948_949insC	c.(946-951)CCCGAAfs	p.P316fs		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	316_317	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		AACTCCTCTTCGGGGGGAAACT	0.47			NA											10	715	---	---	---	---	NA	NA	NA	NA	NA
TRUB1	142940	broad.mit.edu	37	10	116730191	116730192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr10:116730191_116730192insC	uc001lcd.2	+	5	649_650	c.588_589insC	c.(586-591)GTGCCCfs	p.V196fs	TRUB1_uc010qsl.1_Frame_Shift_Ins_p.V98fs	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	196_197					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		TAATGCAAGTGCCCCCCCTGTA	0.317			NA											9	292	---	---	---	---	NA	NA	NA	NA	NA
OR52B6	340980	broad.mit.edu	37	11	5602545	5602546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:5602545_5602546insC	uc010qzi.1	+	1	439_440	c.439_440insC	c.(439-441)TCCfs	p.S147fs	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATCTGCTCCCCCCTGCGA	0.51			NA											9	953	---	---	---	---	NA	NA	NA	NA	NA
DCHS1	8642	broad.mit.edu	37	11	6662141	6662142	+	Frame_Shift_Ins	INS	-	-	G	rs143767864	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:6662141_6662142insG	uc001mem.1	-	2	1113_1114	c.703_704insC	c.(703-705)CGGfs	p.R235fs		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGAA	0.589			NA											8	123	---	---	---	---	NA	NA	NA	NA	NA
PSMA1	5682	broad.mit.edu	37	11	14529252	14529254	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CAT	CAT	-	-	CAT	CAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:14529252_14529254delCAT	uc001mlk.2	-	9	829_831	c.683_685delATG	c.(682-687)GATGTG>GTG	p.D228del	PSMA1_uc001mll.2_In_Frame_Del_p.D234del|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_In_Frame_Del_p.D203del	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	228					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						AATGGAGACACATCATCATCATC	0.36			NA											7	518	---	---	---	---	NA	NA	NA	NA	NA
PLEKHA7	144100	broad.mit.edu	37	11	16822524	16822525	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:16822524_16822525insA	uc001mmo.2	-	17	2420_2421	c.2405_2406insT	c.(2404-2406)TTCfs	p.F802fs	PLEKHA7_uc010rcu.1_Frame_Shift_Ins_p.F802fs|PLEKHA7_uc010rcv.1_Frame_Shift_Ins_p.F376fs|PLEKHA7_uc001mmn.2_Frame_Shift_Ins_p.F510fs	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	802					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						AGGTCACCTGGAAAAAAAAGGC	0.426			NA											10	464	---	---	---	---	NA	NA	NA	NA	NA
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:34904908_34904909insC	uc001mvs.2	-	6	712_713	c.604_605insG	c.(604-606)GAAfs	p.E202fs	APIP_uc010reo.1_Frame_Shift_Ins_p.E219fs	NM_015957	NP_057041	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity				0	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.45			NA											8	621	---	---	---	---	NA	NA	NA	NA	NA
SLC1A2	6506	broad.mit.edu	37	11	35313880	35313881	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:35313880_35313881insA	uc001mwd.2	-	7	1636_1637	c.1044_1045insT	c.(1042-1047)TTTGCTfs	p.F348fs	SLC1A2_uc001mwe.2_Frame_Shift_Ins_p.F339fs|SLC1A2_uc010rev.1_Frame_Shift_Ins_p.F348fs	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	348_349					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	AAAATGCCAGCAAAAAAGGAGA	0.47	NSCLC(100;1273 1575 12993 16869 47409)|Ovarian(164;45 1946 8965 30452 48454)		NA											7	980	---	---	---	---	NA	NA	NA	NA	NA
PAMR1	25891	broad.mit.edu	37	11	35513669	35513670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:35513669_35513670insC	uc001mwg.2	-	3	345_346	c.302_303insG	c.(301-303)GGTfs	p.G101fs	PAMR1_uc001mwf.2_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rew.1_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rex.1_Frame_Shift_Ins_p.G61fs	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	101					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CATCCAAGGTACCCCCCCATGA	0.52			NA											30	1074	---	---	---	---	NA	NA	NA	NA	NA
FNBP4	23360	broad.mit.edu	37	11	47776187	47776187	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:47776187delC	uc009ylv.2	-	3	496	c.343delG	c.(343-345)GACfs	p.D115fs	FNBP4_uc001ngj.2_Frame_Shift_Del_p.D22fs|FNBP4_uc001ngl.2_Intron	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	115										ovary(1)	1						TCATCACTGTCAGCATAAGCA	0.383			NA											103	298	---	---	---	---	NA	NA	NA	NA	NA
SLC43A3	29015	broad.mit.edu	37	11	57185234	57185235	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:57185234_57185235insG	uc001nkg.2	-	8	1067_1068	c.657_658insC	c.(655-660)CCCAACfs	p.P219fs	PRG2_uc001nke.2_Frame_Shift_Ins_p.P118fs|SLC43A3_uc001nkh.2_Frame_Shift_Ins_p.P219fs|SLC43A3_uc010rjr.1_Frame_Shift_Ins_p.P232fs|SLC43A3_uc009yme.2_Frame_Shift_Ins_p.P219fs|SLC43A3_uc001nki.2_Frame_Shift_Ins_p.P219fs|SLC43A3_uc009ymf.1_Frame_Shift_Ins_p.P219fs|SLC43A3_uc010rjs.1_Frame_Shift_Ins_p.P219fs|SLC43A3_uc009ymg.1_Frame_Shift_Ins_p.P232fs	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	219_220					transmembrane transport	integral to membrane				central_nervous_system(1)	1						TAGCTGTAGTTGGGGGGCAGTG	0.564			NA											9	230	---	---	---	---	NA	NA	NA	NA	NA
OR4D10	390197	broad.mit.edu	37	11	59245351	59245352	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:59245351_59245352insG	uc001nnz.1	+	1	449_450	c.449_450insG	c.(448-450)TTGfs	p.L150fs		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GCTGCCTGGTTGGGGGGCTTTG	0.54			NA											7	268	---	---	---	---	NA	NA	NA	NA	NA
CPSF7	79869	broad.mit.edu	37	11	61183884	61183885	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:61183884_61183885insG	uc001nrq.2	-	6	791_792	c.657_658insC	c.(655-660)CCCAGTfs	p.P219fs	CPSF7_uc001nro.2_Frame_Shift_Ins_p.P210fs|CPSF7_uc001nrp.2_Frame_Shift_Ins_p.P262fs|CPSF7_uc001nrr.2_Frame_Shift_Ins_p.P210fs|CPSF7_uc001nrs.1_Frame_Shift_Ins_p.P120fs	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	219_220	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GGCAGCACACTGGGGGGCTTAT	0.594			NA											8	468	---	---	---	---	NA	NA	NA	NA	NA
PPFIA1	8500	broad.mit.edu	37	11	70194406	70194407	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:70194406_70194407insC	uc001opo.2	+	16	2241_2242	c.2043_2044insC	c.(2041-2046)ATTCCCfs	p.I681fs	PPFIA1_uc001opn.1_Frame_Shift_Ins_p.I681fs|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	681_682					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGAGCTCCATTCCCCCCTACCC	0.554			NA											7	470	---	---	---	---	NA	NA	NA	NA	NA
MYO7A	4647	broad.mit.edu	37	11	76873960	76873961	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:76873960_76873961insC	uc001oyb.2	+	14	1888_1889	c.1616_1617insC	c.(1615-1617)ATCfs	p.I539fs	MYO7A_uc010rsl.1_Frame_Shift_Ins_p.I539fs|MYO7A_uc010rsm.1_Frame_Shift_Ins_p.I528fs|MYO7A_uc001oyc.2_Frame_Shift_Ins_p.I539fs	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	539	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCCAACTACATCCCCCCCAAGA	0.564			NA											9	232	---	---	---	---	NA	NA	NA	NA	NA
GRM5	2915	broad.mit.edu	37	11	88258517	88258518	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:88258517_88258518insG	uc001pcq.2	-	8	2885_2886	c.2685_2686insC	c.(2683-2688)CCCAAAfs	p.P895fs	GRM5_uc009yvm.2_Intron	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	895_896	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ATACTCCCTTTGGGGGTGAAAC	0.485			NA											11	1067	---	---	---	---	NA	NA	NA	NA	NA
RDX	5962	broad.mit.edu	37	11	110104136	110104137	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:110104136_110104137insG	uc001pku.2	-	13	1722_1723	c.1412_1413insC	c.(1411-1413)CCTfs	p.P471fs	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Frame_Shift_Ins_p.P471fs|RDX_uc009yxz.2_Frame_Shift_Ins_p.P124fs|RDX_uc009yya.2_Intron|RDX_uc001pks.2_Frame_Shift_Ins_p.P5fs|RDX_uc001pkt.2_Frame_Shift_Ins_p.P125fs|RDX_uc010rwe.1_Frame_Shift_Ins_p.P335fs	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	471	Poly-Pro.|Glu-rich.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GTGGAGGTGGAGGGGGGGCAGA	0.431	Esophageal Squamous(55;25 1062 11040 28755 44273)		NA											20	677	---	---	---	---	NA	NA	NA	NA	NA
NCAM1	4684	broad.mit.edu	37	11	113076860	113076861	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:113076860_113076861insG	uc009yyq.1	+	5	926_927	c.232_233insG	c.(232-234)CGGfs	p.R78fs	NCAM1_uc001pno.2_Frame_Shift_Ins_p.R78fs	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	196	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AATCCTGGCACGGGGGGAGATC	0.495			NA											20	1557	---	---	---	---	NA	NA	NA	NA	NA
SIK3	23387	broad.mit.edu	37	11	116733010	116733011	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:116733010_116733011insC	uc001ppy.2	-	16	1854_1855	c.1818_1819insG	c.(1816-1821)GGGCAGfs	p.G606fs	SIK3_uc001ppz.2_Frame_Shift_Ins_p.G505fs|SIK3_uc001pqa.2_Frame_Shift_Ins_p.G606fs|SIK3_uc001ppw.2_Frame_Shift_Ins_p.G23fs|SIK3_uc001ppx.2_Frame_Shift_Ins_p.G81fs|SIK3_uc001pqb.2_5'Flank	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	606_607	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TCATCAATCTGCCCCCCGTACA	0.5			NA											8	452	---	---	---	---	NA	NA	NA	NA	NA
DSCAML1	57453	broad.mit.edu	37	11	117321331	117321332	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:117321331_117321332insG	uc001prh.1	-	20	3823_3824	c.3821_3822insC	c.(3820-3822)CCTfs	p.P1274fs		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1214	Extracellular (Potential).|Fibronectin type-III 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGGGCTTGGTAGGGGGGAGCCA	0.589			NA											10	385	---	---	---	---	NA	NA	NA	NA	NA
CCDC153	283152	broad.mit.edu	37	11	119061042	119061043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:119061042_119061043insG	uc010rze.1	-	7	687_688	c.599_600insC	c.(598-600)CCTfs	p.P200fs		NM_001145018	NP_001138490	Q494R4	CC153_HUMAN	coiled-coil domain containing 153	200											0						TCAAAGATCCAGGGGGGGTGAG	0.569			NA											12	224	---	---	---	---	NA	NA	NA	NA	NA
JAM3	83700	broad.mit.edu	37	11	134018467	134018468	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr11:134018467_134018468insG	uc001qhb.1	+	7	897_898	c.873_874insG	c.(871-876)ATTGGGfs	p.I291fs	JAM3_uc009zcz.1_Frame_Shift_Ins_p.I240fs	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	246_247	Helical; (Potential).				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GCGGAATTATTGGGGGGGTTCT	0.485			NA											12	337	---	---	---	---	NA	NA	NA	NA	NA
KDM5A	5927	broad.mit.edu	37	12	442810	442811	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:442810_442811insC	uc001qif.1	-	12	1858_1859	c.1495_1496insG	c.(1495-1497)GAGfs	p.E499fs	KDM5A_uc001qie.1_Frame_Shift_Ins_p.E499fs|KDM5A_uc010sdn.1_Frame_Shift_Ins_p.E458fs|KDM5A_uc010sdo.1_Frame_Shift_Ins_p.E118fs	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	499	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TGTCTTTGGCTCCCCCCTAGCA	0.307			NA	T 	NUP98	AML								7	565	---	---	---	---	NA	NA	NA	NA	NA
VWF	7450	broad.mit.edu	37	12	6091108	6091109	+	Frame_Shift_Ins	INS	-	-	G	rs61750632		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:6091108_6091109insG	uc001qnn.1	-	42	7380_7381	c.7130_7131insC	c.(7129-7131)CCGfs	p.P2377fs	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2377					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GCAAACGGTGCGGGGGGCAGGA	0.604			NA											7	194	---	---	---	---	NA	NA	NA	NA	NA
CLSTN3	9746	broad.mit.edu	37	12	7288059	7288060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:7288059_7288060insC	uc001qsr.2	+	4	798_799	c.520_521insC	c.(520-522)TCCfs	p.S174fs	CLSTN3_uc001qss.2_Frame_Shift_Ins_p.S186fs	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	174	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CGGTGACTGCTCCCCCCAGTAC	0.574			NA											7	880	---	---	---	---	NA	NA	NA	NA	NA
A2ML1	144568	broad.mit.edu	37	12	9001442	9001443	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:9001442_9001443insC	uc001quz.3	+	16	2058_2059	c.1960_1961insC	c.(1960-1962)TCGfs	p.S654fs	A2ML1_uc001qva.1_Frame_Shift_Ins_p.S234fs|A2ML1_uc010sgm.1_Frame_Shift_Ins_p.S154fs	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	498						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						CCAAGGGCATTCGAGCCAGCGT	0.525			NA											7	1893	---	---	---	---	NA	NA	NA	NA	NA
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:14019043_14019044insG	uc001rbt.2	-	2	278_279	c.99_100insC	c.(97-102)CCCAGCfs	p.P33fs		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	33_34	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589			NA											9	176	---	---	---	---	NA	NA	NA	NA	NA
RERG	85004	broad.mit.edu	37	12	15262411	15262412	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:15262411_15262412insC	uc001rcs.2	-	4	372_373	c.232_233insG	c.(232-234)GAAfs	p.E78fs	RERG_uc001rct.2_Frame_Shift_Ins_p.E78fs|RERG_uc010shu.1_Frame_Shift_Ins_p.E59fs	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	78					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CACAAAGCCTTCCCCCCATCGC	0.46			NA											8	1090	---	---	---	---	NA	NA	NA	NA	NA
C12orf10	60314	broad.mit.edu	37	12	53693998	53693999	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:53693998_53693999insG	uc001scp.3	+	2	333_334	c.281_282insG	c.(280-282)GTGfs	p.V94fs	C12orf10_uc010sof.1_Frame_Shift_Ins_p.V94fs|C12orf10_uc009zmx.2_Frame_Shift_Ins_p.V94fs|C12orf10_uc001scq.3_5'UTR	NM_021640	NP_067653	Q86UA3	Q86UA3_HUMAN	MYG1 protein precursor	94										ovary(2)	2						GTGGTGGACGTGGGGGGCGAGT	0.559			NA									OREG0021864	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	151	---	---	---	---	NA	NA	NA	NA	NA
AAAS	8086	broad.mit.edu	37	12	53715141	53715142	+	Frame_Shift_Ins	INS	-	-	G	rs138043864		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:53715141_53715142insG	uc001scr.3	-	1	271_272	c.108_109insC	c.(106-111)CCCGACfs	p.P36fs	AAAS_uc001scs.3_Frame_Shift_Ins_p.P36fs	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	36_37					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						CCCCGGAAGTCGGGGGGCGGGC	0.653			NA											8	76	---	---	---	---	NA	NA	NA	NA	NA
PDE1B	5153	broad.mit.edu	37	12	54971059	54971060	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:54971059_54971060insC	uc001sgd.1	+	15	1724_1725	c.1558_1559insC	c.(1558-1560)GCCfs	p.A520fs	PDE1B_uc010soz.1_Frame_Shift_Ins_p.A383fs|PDE1B_uc010spa.1_Frame_Shift_Ins_p.A479fs|PDE1B_uc001sgf.2_Frame_Shift_Ins_p.A383fs|PDE1B_uc001sge.2_Frame_Shift_Ins_p.A500fs|PDE1B_uc009znq.2_Frame_Shift_Ins_p.A316fs	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	520					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGAAGAAGAGGCCCCCCCATCC	0.559			NA											14	336	---	---	---	---	NA	NA	NA	NA	NA
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:56347513_56347514insC	uc001sij.2	+	24	2433_2434	c.2169_2170insC	c.(2167-2172)CCACCCfs	p.P723fs	DGKA_uc001sik.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sil.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sim.2_Frame_Shift_Ins_p.P723fs|DGKA_uc001sin.2_Frame_Shift_Ins_p.P723fs|DGKA_uc009zof.2_Frame_Shift_Ins_p.P369fs|DGKA_uc001sio.2_Frame_Shift_Ins_p.P465fs	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723_724					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579			NA											10	340	---	---	---	---	NA	NA	NA	NA	NA
GLI1	2735	broad.mit.edu	37	12	57860074	57860075	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:57860074_57860075insG	uc001snx.2	+	8	892_893	c.814_815insG	c.(814-816)TGGfs	p.W272fs	GLI1_uc009zpq.2_Frame_Shift_Ins_p.W144fs	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	272	C2H2-type 2.				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CGTGTGCCACTGGGGGGGCTGC	0.599	Pancreas(157;841 1936 10503 41495 50368)		NA											16	335	---	---	---	---	NA	NA	NA	NA	NA
LRIG3	121227	broad.mit.edu	37	12	59282620	59282621	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:59282620_59282621insC	uc001sqr.2	-	6	1029_1030	c.783_784insG	c.(781-786)GGGCTGfs	p.G261fs	LRIG3_uc009zqh.2_Frame_Shift_Ins_p.G201fs|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	261_262						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			ATGTTGCTCAGCCCCCAAAAAG	0.411			NA											7	370	---	---	---	---	NA	NA	NA	NA	NA
MDM2	4193	broad.mit.edu	37	12	69233089	69233090	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:69233089_69233090insC	uc001sui.2	+	11	1241_1242	c.954_955insC	c.(952-957)AATCCCfs	p.N318fs	MDM2_uc009zri.2_Frame_Shift_Ins_p.N273fs|MDM2_uc009zqx.2_Frame_Shift_Ins_p.N263fs|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Frame_Shift_Ins_p.N137fs|MDM2_uc009zqz.2_Frame_Shift_Ins_p.N265fs|MDM2_uc009zra.2_Frame_Shift_Ins_p.N116fs|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Frame_Shift_Ins_p.N2fs|MDM2_uc009zrc.2_Frame_Shift_Ins_p.N2fs|MDM2_uc009zre.2_Frame_Shift_Ins_p.N59fs|MDM2_uc009zrf.2_Frame_Shift_Ins_p.N2fs|MDM2_uc001suo.2_Frame_Shift_Ins_p.N112fs|MDM2_uc009zrg.2_Frame_Shift_Ins_p.N34fs|MDM2_uc009zrh.2_Frame_Shift_Ins_p.N86fs	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	312_313	RanBP2-type.|Necessary for interaction with USP2.|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ATGAAATGAATCCCCCCCTTCC	0.426			NA	A		sarcoma|glioma|colorectal|other								15	520	---	---	---	---	NA	NA	NA	NA	NA
NAV3	89795	broad.mit.edu	37	12	78400511	78400512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:78400511_78400512insC	uc001syp.2	+	8	1366_1367	c.1193_1194insC	c.(1192-1194)CGCfs	p.R398fs	NAV3_uc001syo.2_Frame_Shift_Ins_p.R398fs	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACTGCTTTACGCCCCCCGCAGC	0.495			NA								HNSCC(70;0.22)			11	339	---	---	---	---	NA	NA	NA	NA	NA
PPFIA2	8499	broad.mit.edu	37	12	81741386	81741387	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:81741386_81741387insG	uc001szo.1	-	18	2318_2319	c.2157_2158insC	c.(2155-2160)CCCAGTfs	p.P719fs	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	645_646										ovary(3)|lung(2)|pancreas(1)	6						GAGTGTCCACTGGGGGGAGATG	0.55			NA											16	472	---	---	---	---	NA	NA	NA	NA	NA
UHRF1BP1L	23074	broad.mit.edu	37	12	100451839	100451840	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:100451839_100451840insG	uc001tgq.2	-	14	3444_3445	c.3215_3216insC	c.(3214-3216)CCAfs	p.P1072fs	UHRF1BP1L_uc001tgp.2_Frame_Shift_Ins_p.P722fs	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1072										ovary(2)	2						GTGTTCTAACTGGGGGGGTCTC	0.371			NA											12	408	---	---	---	---	NA	NA	NA	NA	NA
STAB2	55576	broad.mit.edu	37	12	104126791	104126792	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:104126791_104126792insT	uc001tjw.2	+	51	5477_5478	c.5291_5292insT	c.(5290-5292)GGTfs	p.G1764fs	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1764	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CAGGACTCAGGTTTGCTGAGTG	0.569			NA											154	263	---	---	---	---	NA	NA	NA	NA	NA
SLC24A6	80024	broad.mit.edu	37	12	113758305	113758306	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:113758305_113758306insG	uc001tvc.2	-	7	737	c.527_splice	c.e7-1	p.G176_splice	SLC24A6_uc001tuz.2_5'Flank|SLC24A6_uc001tva.2_Splice_Site|SLC24A6_uc001tvb.2_Intron	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor						response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						CGCCAGCGCCTGGGGGGAGGAG	0.644			NA											7	530	---	---	---	---	NA	NA	NA	NA	NA
KSR2	283455	broad.mit.edu	37	12	117977604	117977605	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:117977604_117977605insG	uc001two.2	-	10	1574_1575	c.1519_1520insC	c.(1519-1521)CTCfs	p.L507fs		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTAGGAGGGAGGGGGGGTGCT	0.634			NA											9	135	---	---	---	---	NA	NA	NA	NA	NA
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:120800902_120800903insC	uc001tye.1	-	6	409_410	c.345_346insG	c.(343-348)GGGCTGfs	p.G115fs		NM_002442	NP_002433	O43347	MSI1H_HUMAN	musashi 1	115_116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			central_nervous_system(2)|breast(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564			NA											7	117	---	---	---	---	NA	NA	NA	NA	NA
POLE	5426	broad.mit.edu	37	12	133245023	133245024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr12:133245023_133245024insG	uc001uks.1	-	19	2135_2136	c.2091_2092insC	c.(2089-2094)CCCTTGfs	p.P697fs	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Frame_Shift_Ins_p.P670fs	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	697_698					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCTGGGAACAAGGGGGGGAACT	0.599			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	140	---	---	---	---	NA	NA	NA	NA	NA
KBTBD6	89890	broad.mit.edu	37	13	41705321	41705322	+	Frame_Shift_Ins	INS	-	-	C	rs147771080		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:41705321_41705322insC	uc001uxu.1	-	1	1615_1616	c.1326_1327insG	c.(1324-1329)GGGCGAfs	p.G442fs	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Frame_Shift_Ins_p.G376fs|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	442_443	Kelch 2.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATAGGGTCTCGCCCCCCCAAAA	0.47			NA											21	377	---	---	---	---	NA	NA	NA	NA	NA
MBNL2	10150	broad.mit.edu	37	13	97928603	97928604	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr13:97928603_97928604insC	uc010aft.2	+	2	930_931	c.114_115insC	c.(112-117)CATCCCfs	p.H38fs	MBNL2_uc001vmz.2_Frame_Shift_Ins_p.H38fs|MBNL2_uc001vna.2_Frame_Shift_Ins_p.H38fs|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Frame_Shift_Ins_p.H38fs	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	38_39	C3H1-type 1.				mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			AATTTGCTCATCCCCCCAAAAG	0.411			NA											7	375	---	---	---	---	NA	NA	NA	NA	NA
SUPT16H	11198	broad.mit.edu	37	14	21820849	21820850	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:21820849_21820850insG	uc001wao.2	-	26	3465_3466	c.3126_3127insC	c.(3124-3129)CCCAAGfs	p.P1042fs	SUPT16H_uc001wan.2_Frame_Shift_Ins_p.P186fs	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	1042_1043					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTCTTTTTCTTGGGGGGTGCAG	0.48			NA											10	612	---	---	---	---	NA	NA	NA	NA	NA
ACIN1	22985	broad.mit.edu	37	14	23549377	23549378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:23549377_23549378insG	uc001wit.3	-	6	1668_1669	c.1340_1341insC	c.(1339-1341)CCTfs	p.P447fs	ACIN1_uc001wis.3_Frame_Shift_Ins_p.A129fs|ACIN1_uc010akg.2_Frame_Shift_Ins_p.A447fs|ACIN1_uc010tnj.1_Frame_Shift_Ins_p.A407fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	447					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GAATGAGGACAGCGGGGGCTGG	0.5			NA											8	181	---	---	---	---	NA	NA	NA	NA	NA
SLC7A8	23428	broad.mit.edu	37	14	23608664	23608665	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:23608664_23608665insG	uc001wiz.2	-	6	1606_1607	c.880_881insC	c.(880-882)CAGfs	p.Q294fs	SLC7A8_uc001wix.2_Frame_Shift_Ins_p.Q91fs|SLC7A8_uc010tnk.1_Frame_Shift_Ins_p.Q70fs|SLC7A8_uc010tnl.1_Frame_Shift_Ins_p.Q189fs|SLC7A8_uc001wiy.2_Intron|SLC7A8_uc010akj.2_Intron	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	294					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CAGCAGCTCCTGGGGGGACATT	0.52			NA											7	471	---	---	---	---	NA	NA	NA	NA	NA
REC8	9985	broad.mit.edu	37	14	24642563	24642564	+	Frame_Shift_Ins	INS	-	-	T	rs148175635	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:24642563_24642564insT	uc001wmr.2	+	6	832_833	c.405_406insT	c.(403-408)CCCTTTfs	p.P135fs	REC8_uc001wms.2_Frame_Shift_Ins_p.P135fs	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	135_136					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CTCCAGATCCCTTTTTTGGGAT	0.53	NSCLC(139;1764 2537 12868 49041)		NA											7	267	---	---	---	---	NA	NA	NA	NA	NA
AKAP6	9472	broad.mit.edu	37	14	32902724	32902725	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:32902724_32902725insC	uc001wrq.2	+	2	195_196	c.25_26insC	c.(25-27)TCCfs	p.S9fs	AKAP6_uc010aml.2_Frame_Shift_Ins_p.S6fs	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	9					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGTGACACTTTCCCCCCTGAGG	0.505	Melanoma(49;821 1200 7288 13647 42351)		NA											7	469	---	---	---	---	NA	NA	NA	NA	NA
SAMD4A	23034	broad.mit.edu	37	14	55203891	55203892	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:55203891_55203892insC	uc001xbb.2	+	3	863_864	c.862_863insC	c.(862-864)GCCfs	p.A288fs	SAMD4A_uc001xbc.2_Intron	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	289					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						ATCCGATCATGCCCCCCTGTCT	0.525			NA											9	698	---	---	---	---	NA	NA	NA	NA	NA
KCNH5	27133	broad.mit.edu	37	14	63174302	63174303	+	Frame_Shift_Ins	INS	-	-	G	rs35940222		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:63174302_63174303insG	uc001xfx.2	-	11	2941_2942	c.2890_2891insC	c.(2890-2892)CAGfs	p.Q964fs	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	964	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATGGTATCTGGGGGGGTACT	0.381			NA											16	458	---	---	---	---	NA	NA	NA	NA	NA
TSHR	7253	broad.mit.edu	37	14	81610521	81610522	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:81610521_81610522insG	uc001xvd.1	+	10	2275_2276	c.2119_2120insG	c.(2119-2121)CGGfs	p.R707fs		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	707	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCAGGCATACCGGGGGCAGAGG	0.49			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						8	615	---	---	---	---	NA	NA	NA	NA	NA
GALC	2581	broad.mit.edu	37	14	88406276	88406276	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:88406276delT	uc001xvt.2	-	16	2283	c.1884delA	c.(1882-1884)AAAfs	p.K628fs	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Frame_Shift_Del_p.K602fs|GALC_uc010tvy.1_Frame_Shift_Del_p.K605fs|GALC_uc010tvz.1_Frame_Shift_Del_p.K572fs	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	628					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						GTGTATACCATTTTTTTGCTG	0.308			NA											9	1005	---	---	---	---	NA	NA	NA	NA	NA
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	-	AGTAATACACGGCA			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.55			NA											7	41	---	---	---	---	NA	NA	NA	NA	NA
OR4M2	390538	broad.mit.edu	37	15	22369023	22369024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:22369023_22369024insG	uc010tzu.1	+	1	448_449	c.448_449insG	c.(448-450)AGGfs	p.R150fs	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCTCCTGGAGGGGGGGCTTC	0.5			NA											32	754	---	---	---	---	NA	NA	NA	NA	NA
FMN1	342184	broad.mit.edu	37	15	33357207	33357208	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:33357207_33357208insG	uc001zhf.3	-	2	1442_1443	c.1442_1443insC	c.(1441-1443)CCAfs	p.P481fs	FMN1_uc001zhg.2_Frame_Shift_Ins_p.P481fs	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	704	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTTTTGTCTTTGGGGGTGGCCA	0.495			NA											7	749	---	---	---	---	NA	NA	NA	NA	NA
RYR3	6263	broad.mit.edu	37	15	34015000	34015001	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:34015000_34015001insG	uc001zhi.2	+	44	6774_6775	c.6704_6705insG	c.(6703-6705)GAGfs	p.E2235fs	RYR3_uc010bar.2_Frame_Shift_Ins_p.E2235fs	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2235	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGCGGGGTGAGGGGGGAAACG	0.584			NA											7	243	---	---	---	---	NA	NA	NA	NA	NA
RYR3	6263	broad.mit.edu	37	15	34078053	34078054	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:34078053_34078054insC	uc001zhi.2	+	66	9529_9530	c.9459_9460insC	c.(9457-9462)CTGCCCfs	p.L3153fs	RYR3_uc010bar.2_Frame_Shift_Ins_p.L3153fs	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3153_3154					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGAGAACCTGCCCCCCAGCAC	0.564			NA											9	345	---	---	---	---	NA	NA	NA	NA	NA
BUB1B	701	broad.mit.edu	37	15	40477505	40477506	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:40477505_40477506insC	uc001zkx.3	+	7	1103_1104	c.891_892insC	c.(889-894)GCACCCfs	p.A297fs	BUB1B_uc010ucl.1_Frame_Shift_Ins_p.A160fs	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	297_298					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		CATGGATAGCACCCCCCATGCC	0.475			NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				8	566	---	---	---	---	NA	NA	NA	NA	NA
C15orf52	388115	broad.mit.edu	37	15	40630771	40630772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:40630771_40630772insG	uc001zlh.3	-	5	625_626	c.609_610insC	c.(607-612)CCCACGfs	p.P203fs	C15orf52_uc001zli.1_Frame_Shift_Ins_p.P135fs|C15orf52_uc010ucn.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	203_204										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCCACCTGCGTGGGGGGGCTTC	0.584			NA									OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	91	---	---	---	---	NA	NA	NA	NA	NA
RTF1	23168	broad.mit.edu	37	15	41762468	41762469	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:41762468_41762469insA	uc001zny.2	+	7	915_916	c.903_904insA	c.(901-906)GCCAAAfs	p.A301fs		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	301_302	Lys-rich.|Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		AGCTCCTTGCCAAAAAACAGCC	0.406			NA											10	304	---	---	---	---	NA	NA	NA	NA	NA
TTBK2	146057	broad.mit.edu	37	15	43075687	43075688	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:43075687_43075688insG	uc001zqo.2	-	11	1565_1566	c.1126_1127insC	c.(1126-1128)CGTfs	p.R376fs	TTBK2_uc010bcy.2_Frame_Shift_Ins_p.R307fs|TTBK2_uc001zqp.2_Frame_Shift_Ins_p.R376fs|TTBK2_uc010bcz.1_Frame_Shift_Ins_p.R341fs	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	376					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTCCTGGGGACGGGGGTGTCCC	0.371			NA											7	1139	---	---	---	---	NA	NA	NA	NA	NA
WDR72	256764	broad.mit.edu	37	15	53908070	53908071	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:53908070_53908071insT	uc002acj.2	-	15	2374_2375	c.2332_2333insA	c.(2332-2334)ATGfs	p.M778fs	WDR72_uc010bfi.1_Frame_Shift_Ins_p.M778fs	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	778										lung(1)|skin(1)	2				all cancers(107;0.0511)		CTTAGGCTGCATTTTTTTGGAG	0.391			NA											9	1143	---	---	---	---	NA	NA	NA	NA	NA
HERC1	8925	broad.mit.edu	37	15	63918305	63918306	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:63918305_63918306insG	uc002amp.2	-	71	13301_13302	c.13153_13154insC	c.(13153-13155)CAGfs	p.Q4385fs		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4385					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CGCCCCATACTGGGGGGGCACT	0.559			NA											7	92	---	---	---	---	NA	NA	NA	NA	NA
ZNF609	23060	broad.mit.edu	37	15	64967993	64967994	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr15:64967993_64967994insC	uc002ann.2	+	4	2940_2941	c.2940_2941insC	c.(2938-2943)GTACCCfs	p.V980fs		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	980_981						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ATGCCTATGTACCCCCCTATGG	0.55			NA											9	1149	---	---	---	---	NA	NA	NA	NA	NA
GPR139	124274	broad.mit.edu	37	16	20043388	20043389	+	Frame_Shift_Ins	INS	-	-	G	rs140063049	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20043388_20043389insG	uc002dgu.1	-	2	892_893	c.730_731insC	c.(730-732)CGCfs	p.R244fs	GPR139_uc010vaw.1_Frame_Shift_Ins_p.R151fs	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	244	Helical; Name=6; (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CATGATGATGCGGGGGGCCCAA	0.545			NA											7	194	---	---	---	---	NA	NA	NA	NA	NA
ACSM2A	123876	broad.mit.edu	37	16	20489924	20489925	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20489924_20489925insC	uc010bwe.2	+	11	1445_1446	c.1206_1207insC	c.(1204-1209)CTGCCCfs	p.L402fs	ACSM2A_uc010vax.1_Frame_Shift_Ins_p.L323fs|ACSM2A_uc002dhf.3_Frame_Shift_Ins_p.L402fs|ACSM2A_uc002dhg.3_Frame_Shift_Ins_p.L402fs|ACSM2A_uc010vay.1_Frame_Shift_Ins_p.L323fs|ACSM2A_uc002dhh.3_Frame_Shift_Ins_p.L32fs	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	402_403					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GCAACGTCCTGCCCCCCGGCAC	0.505			NA											12	379	---	---	---	---	NA	NA	NA	NA	NA
ACSM2B	348158	broad.mit.edu	37	16	20556547	20556548	+	Frame_Shift_Ins	INS	-	-	G	rs146499503		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:20556547_20556548insG	uc002dhj.3	-	11	1422_1423	c.1212_1213insC	c.(1210-1215)CCCGGCfs	p.P404fs	ACSM2B_uc002dhk.3_Frame_Shift_Ins_p.P404fs|ACSM2B_uc010bwf.1_Frame_Shift_Ins_p.P404fs	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	404_405					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CCTTCTGTGCCGGGGGGCAGGA	0.515			NA											7	349	---	---	---	---	NA	NA	NA	NA	NA
DNAH3	55567	broad.mit.edu	37	16	21063027	21063028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:21063027_21063028insG	uc010vbe.1	-	29	4201_4202	c.4201_4202insC	c.(4201-4203)CGGfs	p.R1401fs		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1401	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GATCACCAGCCGGGGGGAGTTT	0.569			NA											14	553	---	---	---	---	NA	NA	NA	NA	NA
USP31	57478	broad.mit.edu	37	16	23079851	23079852	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:23079851_23079852insC	uc002dll.2	-	16	3574_3575	c.3574_3575insG	c.(3574-3576)GCCfs	p.A1192fs	USP31_uc002dlk.2_Frame_Shift_Ins_p.A464fs|USP31_uc010vca.1_Frame_Shift_Ins_p.A495fs|USP31_uc010bxm.2_Frame_Shift_Ins_p.A480fs	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1192	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GTGCTTCCCGGCCCCCCTGCCC	0.644			NA											7	151	---	---	---	---	NA	NA	NA	NA	NA
TNRC6A	27327	broad.mit.edu	37	16	24804889	24804890	+	Frame_Shift_Ins	INS	-	-	G	rs139796934		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:24804889_24804890insG	uc002dmm.2	+	7	3385_3386	c.3271_3272insG	c.(3271-3273)TGGfs	p.W1091fs	TNRC6A_uc010bxs.2_Frame_Shift_Ins_p.W838fs|TNRC6A_uc010vcc.1_Frame_Shift_Ins_p.W838fs|TNRC6A_uc002dmn.2_Frame_Shift_Ins_p.W838fs|TNRC6A_uc002dmo.2_Intron	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1091	Sufficient for interaction with EIF2C1 and EIF2C4.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGGTCCCAGCTGGGGGGAACCC	0.55			NA											8	487	---	---	---	---	NA	NA	NA	NA	NA
SEZ6L2	26470	broad.mit.edu	37	16	29891248	29891249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:29891248_29891249insG	uc002duq.3	-	9	1749_1750	c.1509_1510insC	c.(1507-1512)CCCAATfs	p.P503fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Frame_Shift_Ins_p.P433fs|SEZ6L2_uc002dur.3_Frame_Shift_Ins_p.P433fs|SEZ6L2_uc002dus.3_Frame_Shift_Ins_p.P389fs|SEZ6L2_uc010vec.1_Frame_Shift_Ins_p.P503fs|SEZ6L2_uc010ved.1_Frame_Shift_Ins_p.P459fs	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	503_504	Sushi 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TCGATGGCATTGGGGGGCCCAG	0.604			NA											9	386	---	---	---	---	NA	NA	NA	NA	NA
ITGAD	3681	broad.mit.edu	37	16	31422532	31422533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:31422532_31422533insG	uc002ebv.1	+	13	1541_1542	c.1492_1493insG	c.(1492-1494)AGGfs	p.R498fs	ITGAD_uc010cap.1_Frame_Shift_Ins_p.R498fs	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	498	Extracellular (Potential).|FG-GAP 5.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TCCCTTGCCTAGGGGGGTGAGT	0.629			NA											8	570	---	---	---	---	NA	NA	NA	NA	NA
RBL2	5934	broad.mit.edu	37	16	53504347	53504348	+	Frame_Shift_Ins	INS	-	-	G	rs67487800		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:53504347_53504348insG	uc002ehi.3	+	16	2416_2417	c.2298_2299insG	c.(2296-2301)GTTGGGfs	p.V766fs	RBL2_uc002ehj.2_Frame_Shift_Ins_p.V476fs|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	766_767	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						AAGTCAATGTTGGGGGGCAGGC	0.48			NA											7	401	---	---	---	---	NA	NA	NA	NA	NA
CNOT1	23019	broad.mit.edu	37	16	58577809	58577810	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:58577809_58577810insG	uc002env.2	-	31	4431	c.4138_splice	c.e31-1	p.I1380_splice	CNOT1_uc002enw.2_Splice_Site|CNOT1_uc002enu.3_Splice_Site_p.I1375_splice|CNOT1_uc002enx.2_Intron|CNOT1_uc010vik.1_Splice_Site_p.I337_splice	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAAGGGAATCTGGGGGGTTGGG	0.46			NA											7	158	---	---	---	---	NA	NA	NA	NA	NA
NAE1	8883	broad.mit.edu	37	16	66839678	66839679	+	Splice_Site	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:66839678_66839679insC	uc002eqf.2	-	19	1572	c.1495_splice	c.e19+1	p.G499_splice	NAE1_uc002eqe.2_Splice_Site_p.G493_splice|NAE1_uc002eqg.2_Splice_Site_p.G410_splice|NAE1_uc010cdv.2_Splice_Site_p.G502_splice	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a						apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TATGGAACTCACCCCCCAAGAA	0.406			NA											7	212	---	---	---	---	NA	NA	NA	NA	NA
ZFHX3	463	broad.mit.edu	37	16	72993508	72993509	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:72993508_72993509insC	uc002fck.2	-	2	1209_1210	c.536_537insG	c.(535-537)GGCfs	p.G179fs	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	179					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CCCCTTGCTTGCCCCCCGCGCC	0.639			NA											8	33	---	---	---	---	NA	NA	NA	NA	NA
GLG1	2734	broad.mit.edu	37	16	74525008	74525009	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:74525008_74525009insC	uc002fcy.3	-	8	1389_1390	c.1339_1340insG	c.(1339-1341)GAGfs	p.E447fs	GLG1_uc002fcx.2_Frame_Shift_Ins_p.E447fs|GLG1_uc002fcw.3_Frame_Shift_Ins_p.E436fs|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	447	Extracellular (Potential).|Cys-rich GLG1 6.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GTGTTCAATCTCCCCCCGACAG	0.515			NA											9	283	---	---	---	---	NA	NA	NA	NA	NA
WDR59	79726	broad.mit.edu	37	16	74943495	74943496	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:74943495_74943496insG	uc002fdh.1	-	16	1647_1648	c.1545_1546insC	c.(1543-1548)CCCTTAfs	p.P515fs	WDR59_uc002fdi.2_Frame_Shift_Ins_p.P515fs|WDR59_uc002fdg.1_Frame_Shift_Ins_p.P107fs	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	515_516										ovary(1)|breast(1)	2						AACGTCGGTAAGGGGGGAGTGA	0.554			NA											9	451	---	---	---	---	NA	NA	NA	NA	NA
TERF2IP	54386	broad.mit.edu	37	16	75690386	75690388	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr16:75690386_75690388delTCC	uc002fet.1	+	3	1174_1176	c.1077_1079delTCC	c.(1075-1080)TATCCC>TAC	p.P360del		NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	360					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						CTGATGGATATCCCATTTGGTCC	0.453			NA											9	387	---	---	---	---	NA	NA	NA	NA	NA
RPA1	6117	broad.mit.edu	37	17	1782982	1782983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:1782982_1782983insG	uc002fto.2	+	11	1196_1197	c.1081_1082insG	c.(1081-1083)TGGfs	p.W361fs		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	361					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TGCTACACTGTGGGGGGAAGAT	0.53			NA						NER					7	857	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579470	7579470	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:7579470delC	uc002gim.2	-	4	411	c.217delG	c.(217-219)GTGfs	p.V73fs	TP53_uc002gig.1_Frame_Shift_Del_p.V73fs|TP53_uc002gih.2_Frame_Shift_Del_p.V73fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.V73fs|TP53_uc010cni.1_Frame_Shift_Del_p.V73fs|TP53_uc002gij.2_Frame_Shift_Del_p.V73fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.V34fs|TP53_uc010cnk.1_Frame_Shift_Del_p.V88fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	73	Interaction with WWOX.|Interaction with HRMT1L2.		V -> M (in sporadic cancers; somatic mutation).|V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.V73L(3)|p.G59fs*23(3)|p.V73fs*50(2)|p.V73fs*76(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.V73E(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCA	0.602	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			70	289	---	---	---	---	NA	NA	NA	NA	NA
MYH10	4628	broad.mit.edu	37	17	8409750	8409751	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:8409750_8409751insG	uc002gll.2	-	25	3274_3275	c.3178_3179insC	c.(3178-3180)CTCfs	p.L1060fs	MYH10_uc002glm.2_Frame_Shift_Ins_p.L1091fs|MYH10_uc010cnx.2_Frame_Shift_Ins_p.L1069fs	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1060	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTCCCCGTCGAGTTTTCTTTTG	0.515			NA											8	225	---	---	---	---	NA	NA	NA	NA	NA
MYH3	4621	broad.mit.edu	37	17	10555835	10555836	+	Frame_Shift_Ins	INS	-	-	G	rs139160750		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:10555835_10555836insG	uc002gmq.1	-	3	326_327	c.249_250insC	c.(247-252)CCCAAGfs	p.P83fs		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	83_84	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTGTCGAACTTGGGGGGGTTCA	0.495			NA											12	171	---	---	---	---	NA	NA	NA	NA	NA
PRPSAP2	5636	broad.mit.edu	37	17	18832235	18832236	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:18832235_18832236insC	uc002gup.1	+	11	1127_1128	c.916_917insC	c.(916-918)GCCfs	p.A306fs	PRPSAP2_uc002guo.1_Frame_Shift_Ins_p.A220fs|PRPSAP2_uc010vyi.1_Frame_Shift_Ins_p.A254fs|PRPSAP2_uc010vyj.1_Frame_Shift_Ins_p.A220fs|PRPSAP2_uc010vyk.1_Intron|PRPSAP2_uc002guq.1_Frame_Shift_Ins_p.A93fs	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	306					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						GTCTTCTGACGCCCCCCGGCGG	0.495			NA											10	402	---	---	---	---	NA	NA	NA	NA	NA
SSH2	85464	broad.mit.edu	37	17	27959374	27959375	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:27959374_27959375insG	uc002heo.1	-	15	2756_2757	c.2756_2757insC	c.(2755-2757)CCAfs	p.P919fs	SSH2_uc010wbh.1_Frame_Shift_Ins_p.P946fs	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	919					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						ATGAATGTTCTGGGGGGGCTTC	0.48			NA											22	451	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29562738	29562739	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:29562738_29562739delCT	uc002hgg.2	+	28	4151_4152	c.3818_3819delCT	c.(3817-3819)ACTfs	p.T1273fs	NF1_uc002hgh.2_Frame_Shift_Del_p.T1273fs|NF1_uc010csn.1_Frame_Shift_Del_p.T1133fs|NF1_uc002hgi.1_Frame_Shift_Del_p.T306fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1273	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCCATGCAGACTCTCTTCCGAG	0.416			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			12	558	---	---	---	---	NA	NA	NA	NA	NA
ACACA	31	broad.mit.edu	37	17	35600370	35600371	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:35600370_35600371insG	uc002hnm.2	-	22	2927_2928	c.2736_2737insC	c.(2734-2739)CCCAATfs	p.P912fs	ACACA_uc002hnk.2_Frame_Shift_Ins_p.P834fs|ACACA_uc002hnl.2_Frame_Shift_Ins_p.P854fs|ACACA_uc002hnn.2_Frame_Shift_Ins_p.P912fs|ACACA_uc002hno.2_Frame_Shift_Ins_p.P949fs|ACACA_uc010cuz.2_Frame_Shift_Ins_p.P912fs	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	912_913					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTCTCCACATTGGGGGGAATGC	0.47	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											9	909	---	---	---	---	NA	NA	NA	NA	NA
CNTNAP1	8506	broad.mit.edu	37	17	40843872	40843873	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:40843872_40843873insC	uc002iay.2	+	16	2609_2610	c.2393_2394insC	c.(2392-2394)TTCfs	p.F798fs	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	798	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCACTACGCTTCCCCCCAATCC	0.564			NA											12	643	---	---	---	---	NA	NA	NA	NA	NA
NFE2L1	4779	broad.mit.edu	37	17	46135787	46135788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:46135787_46135788insG	uc002imz.3	+	6	1754_1755	c.1103_1104insG	c.(1102-1104)CTGfs	p.L368fs	NFE2L1_uc002ina.3_Frame_Shift_Ins_p.L338fs|NFE2L1_uc002inb.3_Frame_Shift_Ins_p.L338fs|NFE2L1_uc010wle.1_Frame_Shift_Ins_p.L180fs|NFE2L1_uc010wlf.1_Frame_Shift_Ins_p.L212fs	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	368					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CAGGCGTCCCTGGGGGGCTGCA	0.604			NA											8	280	---	---	---	---	NA	NA	NA	NA	NA
SKAP1	8631	broad.mit.edu	37	17	46262152	46262153	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:46262152_46262153insG	uc002ini.1	-	7	611_612	c.499_500insC	c.(499-501)CACfs	p.H167fs	SKAP1_uc002inj.1_Frame_Shift_Ins_p.H167fs|SKAP1_uc010dbd.1_Frame_Shift_Ins_p.H73fs|SKAP1_uc010dbe.1_Frame_Shift_Ins_p.H167fs	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	167	PH.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						TCTTCGCAGGTGGGGGGCCATC	0.53			NA											7	545	---	---	---	---	NA	NA	NA	NA	NA
RNF43	54894	broad.mit.edu	37	17	56435160	56435161	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:56435160_56435161insC	uc002iwf.2	-	8	3932_3933	c.1976_1977insG	c.(1975-1977)GGTfs	p.G659fs	RNF43_uc010wnv.1_Frame_Shift_Ins_p.G618fs|RNF43_uc002iwh.3_Frame_Shift_Ins_p.G659fs|RNF43_uc002iwg.3_Frame_Shift_Ins_p.G659fs|RNF43_uc010dcw.2_Frame_Shift_Ins_p.G532fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	659	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTCGGAGGGACCCCCCCGCCT	0.599			NA											7	90	---	---	---	---	NA	NA	NA	NA	NA
MARCH10	162333	broad.mit.edu	37	17	60814265	60814266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:60814265_60814266insC	uc010ddr.2	-	6	1201_1202	c.963_964insG	c.(961-966)GGGACAfs	p.G321fs	MARCH10_uc002jag.3_Frame_Shift_Ins_p.G321fs|MARCH10_uc010dds.2_Frame_Shift_Ins_p.G359fs|MARCH10_uc002jah.2_Frame_Shift_Ins_p.G320fs|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	321_322							ligase activity|zinc ion binding				0						GGGGTCGATGTCCCCCCAAATC	0.46			NA											14	1074	---	---	---	---	NA	NA	NA	NA	NA
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr17:67083603_67083604insG	uc002jhw.1	-	29	3884_3885	c.3709_3710insC	c.(3709-3711)CAAfs	p.Q1237fs		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376			NA											18	1725	---	---	---	---	NA	NA	NA	NA	NA
KIAA0802	23255	broad.mit.edu	37	18	8793003	8793004	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:8793003_8793004insC	uc002knr.2	+	8	2037_2038	c.1895_1896insC	c.(1894-1896)GGCfs	p.G632fs	KIAA0802_uc002knq.2_Intron|KIAA0802_uc002kns.2_Intron	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						CAGCTCAGGGGCCCCCCCGTTT	0.554			NA											10	154	---	---	---	---	NA	NA	NA	NA	NA
ALPK2	115701	broad.mit.edu	37	18	56246441	56246442	+	Frame_Shift_Ins	INS	-	-	C	rs12606191	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr18:56246441_56246442insC	uc002lhj.3	-	4	1780_1781	c.1566_1567insG	c.(1564-1569)GGAAAGfs	p.G522fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	522_523							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CATAAGTCCTTTCCCCCCACTC	0.52			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	336	---	---	---	---	NA	NA	NA	NA	NA
MPV17L2	84769	broad.mit.edu	37	19	18305818	18305819	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:18305818_18305819insC	uc002nid.2	+	4	538_539	c.486_487insC	c.(484-489)GTGCCCfs	p.V162fs	MPV17L2_uc010ebj.2_Frame_Shift_Ins_p.A73fs	NM_032683	NP_116072	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	162_163						integral to membrane					0						TCCTCTTCGTGCCCCCCCAATT	0.455			NA											8	88	---	---	---	---	NA	NA	NA	NA	NA
TSHZ3	57616	broad.mit.edu	37	19	31769061	31769062	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:31769061_31769062insC	uc002nsy.3	-	2	1702_1703	c.1637_1638insG	c.(1636-1638)GGCfs	p.G546fs		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	546					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGCTGGGATAGCCCCCCCAGCT	0.559			NA											7	206	---	---	---	---	NA	NA	NA	NA	NA
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:31769141_31769142insC	uc002nsy.3	-	2	1622_1623	c.1557_1558insG	c.(1555-1560)GGGCTTfs	p.G519fs		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	519_520					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.5			NA											9	351	---	---	---	---	NA	NA	NA	NA	NA
ZNF566	84924	broad.mit.edu	37	19	36940725	36940726	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:36940725_36940726insC	uc002oea.3	-	5	492_493	c.410_411insG	c.(409-411)GGAfs	p.G137fs	ZNF566_uc010xte.1_Frame_Shift_Ins_p.G137fs|ZNF566_uc010xtf.1_Frame_Shift_Ins_p.G138fs|ZNF566_uc002oeb.3_Frame_Shift_Ins_p.G137fs|ZNF566_uc002oec.3_Frame_Shift_Ins_p.G33fs|ZNF566_uc010xtg.1_Frame_Shift_Ins_p.G33fs	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GATTGAAATGTCCCCCCTGAGA	0.391			NA											11	477	---	---	---	---	NA	NA	NA	NA	NA
AXL	558	broad.mit.edu	37	19	41743932	41743933	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:41743932_41743933insC	uc010ehj.2	+	7	1057_1058	c.867_868insC	c.(865-870)GTGCCCfs	p.V289fs	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Frame_Shift_Ins_p.V289fs|AXL_uc010ehk.2_Frame_Shift_Ins_p.V289fs	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	289_290	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V289M(1)		lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AAGCATCCGTGCCCCCCCATCA	0.649			NA											8	161	---	---	---	---	NA	NA	NA	NA	NA
GIPR	2696	broad.mit.edu	37	19	46180611	46180611	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:46180611delT	uc002pcu.1	+	9	923	c.824delT	c.(823-825)GTGfs	p.V275fs	GIPR_uc002pct.1_Frame_Shift_Del_p.V275fs|GIPR_uc010xxp.1_Frame_Shift_Del_p.V239fs|GIPR_uc010xxq.1_Intron	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	275	Helical; Name=4; (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		ATTCCCTGGGTGATCGTCAGG	0.706			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
CARD8	22900	broad.mit.edu	37	19	48737669	48737670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr19:48737669_48737670insC	uc002pie.3	-	3	379_380	c.66_67insG	c.(64-69)GGGACAfs	p.G22fs	CARD8_uc002pii.3_Frame_Shift_Ins_p.D114fs|CARD8_uc010xzi.1_Frame_Shift_Ins_p.G22fs|CARD8_uc010els.2_5'Flank|CARD8_uc010xzj.1_Frame_Shift_Ins_p.D114fs|CARD8_uc010xzk.1_Frame_Shift_Ins_p.G46fs|CARD8_uc002pif.3_Frame_Shift_Ins_p.G22fs|CARD8_uc002pig.3_5'UTR|CARD8_uc002pih.3_Frame_Shift_Ins_p.D64fs|CARD8_uc010xzl.1_Frame_Shift_Ins_p.D64fs|CARD8_uc010xzm.1_Frame_Shift_Ins_p.D114fs	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	22_23					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		CCTGGGAATGTCCCCCCCAGAT	0.436			NA											9	326	---	---	---	---	NA	NA	NA	NA	NA
WDR35	57539	broad.mit.edu	37	2	20133236	20133237	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:20133236_20133237delCA	uc002rdi.2	-	23	2724_2725	c.2616_2617delTG	c.(2614-2619)TGTGAAfs	p.C872fs	WDR35_uc002rdj.2_Frame_Shift_Del_p.C861fs|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	872_873										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTGCTTGTTCACACATTCCAA	0.356			NA											113	257	---	---	---	---	NA	NA	NA	NA	NA
BIRC6	57448	broad.mit.edu	37	2	32678942	32678950	+	In_Frame_Del	DEL	AAGTTGAAC	AAGTTGAAC	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	AAGTTGAAC	AAGTTGAAC	-	-	AAGTTGAAC	AAGTTGAAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:32678942_32678950delAAGTTGAAC	uc010ezu.2	+	23	4819_4827	c.4685_4693delAAGTTGAAC	c.(4684-4695)GAAGTTGAACCT>GCT	p.1562_1565EVEP>A		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1562_1565					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGACTTTTGGAAGTTGAACCTCTGCACTT	0.383	Pancreas(94;175 1509 16028 18060 45422)		NA											23	303	---	---	---	---	NA	NA	NA	NA	NA
ANTXR1	84168	broad.mit.edu	37	2	69409763	69409764	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:69409763_69409764insC	uc002sfg.2	+	16	1680_1681	c.1324_1325insC	c.(1324-1326)TCCfs	p.S442fs		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	442	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity	p.S442S(1)		ovary(2)|skin(2)	4						TCGGCCTTCTTCCCCCCGGAAG	0.421			NA							Familial_Infantile_Hemangioma				9	498	---	---	---	---	NA	NA	NA	NA	NA
GMCL1	64395	broad.mit.edu	37	2	70074752	70074753	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:70074752_70074753insA	uc002sfu.2	+	7	1043_1044	c.836_837insA	c.(835-837)CTAfs	p.L279fs		NM_178439	NP_848526	Q96IK5	GMCL1_HUMAN	germ cell-less	279					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3						TACACTGCTCTAAAAAAGGTAC	0.223			NA											7	749	---	---	---	---	NA	NA	NA	NA	NA
RAB11FIP5	26056	broad.mit.edu	37	2	73302654	73302655	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:73302654_73302655insG	uc002siu.3	-	5	2197_2198	c.1956_1957insC	c.(1954-1959)CCCAAAfs	p.P652fs	RAB11FIP5_uc002sis.3_Frame_Shift_Ins_p.P31fs|RAB11FIP5_uc002sit.3_Frame_Shift_Ins_p.P574fs	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	652_653					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GAAGGCTATTTGGGGGGGCCCG	0.629			NA											9	76	---	---	---	---	NA	NA	NA	NA	NA
SEMA4F	10505	broad.mit.edu	37	2	74900582	74900583	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:74900582_74900583insG	uc002sna.1	+	6	662	c.551_splice	c.e6-1	p.G184_splice	SEMA4F_uc010ysb.1_Splice_Site_p.G120_splice|SEMA4F_uc010ffq.1_Splice_Site_p.G151_splice|SEMA4F_uc010ffr.1_Splice_Site|SEMA4F_uc002snb.1_Splice_Site|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor						cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTCGCCCTGCAGGGGGGGTCCT	0.589			NA											7	153	---	---	---	---	NA	NA	NA	NA	NA
HK2	3099	broad.mit.edu	37	2	75104377	75104378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:75104377_75104378insG	uc002snd.2	+	8	2886_2887	c.960_961insG	c.(958-963)TTTGGGfs	p.F320fs		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	320_321	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						AGCTGCTCTTTGGGGGGAAGCT	0.545			NA											10	433	---	---	---	---	NA	NA	NA	NA	NA
KCMF1	56888	broad.mit.edu	37	2	85280407	85280408	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:85280407_85280408insG	uc002sox.3	+	7	1365_1366	c.1021_1022insG	c.(1021-1023)CGGfs	p.R341fs		NM_020122	NP_064507	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	341						intracellular	ligase activity|zinc ion binding			ovary(2)	2						TGAGGATGATCGGGGGGAGATG	0.45			NA											8	199	---	---	---	---	NA	NA	NA	NA	NA
IL1R2	7850	broad.mit.edu	37	2	102638681	102638682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:102638681_102638682insC	uc002tbm.2	+	6	950_951	c.721_722insC	c.(721-723)TCCfs	p.S241fs	IL1R2_uc002tbn.2_Frame_Shift_Ins_p.S241fs|IL1R2_uc002tbo.1_Frame_Shift_Ins_p.S241fs	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	241	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	TGTGATCATTTCCCCCCTCAAG	0.49	Pancreas(106;189 1628 2302 5133 12295)		NA											13	500	---	---	---	---	NA	NA	NA	NA	NA
SLC9A2	6549	broad.mit.edu	37	2	103324745	103324746	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:103324745_103324746insC	uc002tca.2	+	12	2378_2379	c.2236_2237insC	c.(2236-2238)ACCfs	p.T746fs		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	746	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TATGCCCAGCACCCCCCCAACA	0.53			NA											17	310	---	---	---	---	NA	NA	NA	NA	NA
ANAPC1	64682	broad.mit.edu	37	2	112582738	112582739	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:112582738_112582739insG	uc002thi.2	-	23	2957_2958	c.2710_2711insC	c.(2710-2712)CAGfs	p.Q904fs		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	904					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TTGCAACTTCTGGGGGGCTAAA	0.302			NA											8	456	---	---	---	---	NA	NA	NA	NA	NA
NCKAP5	344148	broad.mit.edu	37	2	133541083	133541084	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:133541083_133541084insG	uc002ttp.2	-	14	3674_3675	c.3300_3301insC	c.(3298-3303)CCCAAGfs	p.P1100fs	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1100_1101	Ser-rich.						protein binding				0						AAGGAAGGCTTGGGGGGTGTGG	0.505			NA											7	847	---	---	---	---	NA	NA	NA	NA	NA
R3HDM1	23518	broad.mit.edu	37	2	136389448	136389449	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:136389448_136389449insC	uc002tuo.2	+	9	945_946	c.575_576insC	c.(574-576)TTCfs	p.F192fs	R3HDM1_uc010fni.2_Frame_Shift_Ins_p.F190fs|R3HDM1_uc002tup.2_Frame_Shift_Ins_p.F136fs|R3HDM1_uc010zbh.1_Frame_Shift_Ins_p.F24fs	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	192	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CGTAAAAAATTCCCCCCAATGA	0.396			NA											9	469	---	---	---	---	NA	NA	NA	NA	NA
ACVR2A	92	broad.mit.edu	37	2	148683685	148683686	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:148683685_148683686insA	uc002twg.2	+	11	1571_1572	c.1302_1303insA	c.(1300-1305)CATAAAfs	p.H434fs	ACVR2A_uc010zbn.1_Frame_Shift_Ins_p.H326fs|ACVR2A_uc002twh.2_Frame_Shift_Ins_p.H434fs	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	434_435	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		TTGTTGTGCATAAAAAAAAGAG	0.366			NA											57	314	---	---	---	---	NA	NA	NA	NA	NA
CSRNP3	80034	broad.mit.edu	37	2	166532949	166532950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:166532949_166532950insA	uc002udf.2	+	6	912_913	c.536_537insA	c.(535-537)ACAfs	p.T179fs	CSRNP3_uc002udg.2_Frame_Shift_Ins_p.T179fs	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	179					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						CCTTTGCCAACAAAAAAACGAA	0.48			NA											9	745	---	---	---	---	NA	NA	NA	NA	NA
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:168099957_168099958insG	uc002udx.2	+	8	2073_2074	c.2055_2056insG	c.(2053-2058)ACTGGGfs	p.T685fs	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Frame_Shift_Ins_p.T510fs|XIRP2_uc010fpq.2_Frame_Shift_Ins_p.T463fs|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	510_511					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGACATAACTGGGGGGGATGT	0.421			NA											15	326	---	---	---	---	NA	NA	NA	NA	NA
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:171240258_171240259insC	uc002ufy.2	+	12	1367_1368	c.1224_1225insC	c.(1222-1227)AATCCCfs	p.N408fs	MYO3B_uc002ufv.2_Frame_Shift_Ins_p.N395fs|MYO3B_uc010fqb.1_Frame_Shift_Ins_p.N395fs|MYO3B_uc002ufz.2_Frame_Shift_Ins_p.N408fs|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	408_409	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GCGCCTCCAATCCCCCCCACAT	0.465			NA											13	269	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179611375	179611375	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:179611375delC	uc002unb.2	-	46	15976	c.15752delG	c.(15751-15753)GGAfs	p.G5251fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8770							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGTACTCTCCCCCTTCTCC	0.408			NA											8	255	---	---	---	---	NA	NA	NA	NA	NA
NEUROD1	4760	broad.mit.edu	37	2	182542971	182542972	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:182542971_182542972insG	uc002uof.2	-	2	852_853	c.616_617insC	c.(616-618)CACfs	p.H206fs	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	206					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CGTCGGCAGGTGGGGGGGCATG	0.619			NA											14	178	---	---	---	---	NA	NA	NA	NA	NA
ITGAV	3685	broad.mit.edu	37	2	187521084	187521085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:187521084_187521085insG	uc002upq.2	+	17	1951_1952	c.1675_1676insG	c.(1675-1677)AGGfs	p.R559fs	ITGAV_uc010frs.2_Frame_Shift_Ins_p.R523fs|ITGAV_uc010zfv.1_Frame_Shift_Ins_p.R513fs	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	559	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GACTATTTCAAGGGGGGGACTG	0.431	Melanoma(58;108 1995 6081)		NA											19	710	---	---	---	---	NA	NA	NA	NA	NA
ADAM23	8745	broad.mit.edu	37	2	207460860	207460861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:207460860_207460861insC	uc002vbq.2	+	24	2556_2557	c.2333_2334insC	c.(2332-2334)CACfs	p.H778fs	ADAM23_uc010ziv.1_Intron	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	778	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGGAACCTTCACCCCCCCAAGG	0.455	Melanoma(194;1127 2130 19620 24042 27855)		NA											9	120	---	---	---	---	NA	NA	NA	NA	NA
CXCR2P1	3580	broad.mit.edu	37	2	218925421	218925421	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:218925421delG	uc002vgx.2	-	1	593	c.300delC	c.(298-300)CCCfs	p.P100fs	RUFY4_uc002vgw.2_Intron	NR_002712				Homo sapiens interleukin 8 receptor, beta pseudogene, mRNA (cDNA clone IMAGE:5450999), with apparent retained intron.												0						TGCCCCATATGGGCCTTAAAC	0.552			NA											10	349	---	---	---	---	NA	NA	NA	NA	NA
VIL1	7429	broad.mit.edu	37	2	219301230	219301231	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:219301230_219301231insC	uc002via.2	+	16	1917_1918	c.1852_1853insC	c.(1852-1854)ACCfs	p.T618fs	VIL1_uc010zke.1_Frame_Shift_Ins_p.T307fs|VIL1_uc002vib.2_Frame_Shift_Ins_p.T618fs	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	618	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGGTCATCACCCCCCGGCTC	0.5			NA											12	332	---	---	---	---	NA	NA	NA	NA	NA
GIGYF2	26058	broad.mit.edu	37	2	233708910	233708912	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	AGC	AGC	-	-	AGC	AGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:233708910_233708912delAGC	uc002vti.3	+	26	3381_3383	c.3044_3046delAGC	c.(3043-3048)AAGCAG>AAG	p.Q1022del	GIGYF2_uc002vtj.3_In_Frame_Del_p.Q1043del|GIGYF2_uc002vtk.3_In_Frame_Del_p.Q1022del|GIGYF2_uc002vth.3_In_Frame_Del_p.Q1016del|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_In_Frame_Del_p.A864del|GIGYF2_uc002vtq.3_In_Frame_Del_p.Q355del	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1022	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CAAATGCAAAagcagcagcagca	0.365			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
INPP5D	3635	broad.mit.edu	37	2	234072358	234072359	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:234072358_234072359insC	uc010zmo.1	+	11	1399_1400	c.1246_1247insC	c.(1246-1248)GCCfs	p.A416fs	INPP5D_uc010zmp.1_Frame_Shift_Ins_p.A415fs	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	416					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TGAAGGTAACGCCCCCCCTCCC	0.535	NSCLC(82;1215 1426 16163 20348 41018)		NA											9	368	---	---	---	---	NA	NA	NA	NA	NA
TRPM8	79054	broad.mit.edu	37	2	234879009	234879010	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:234879009_234879010insC	uc002vvh.2	+	17	2334_2335	c.2294_2295insC	c.(2293-2295)CACfs	p.H765fs	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	765	Helical; Name=3; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TCGGTGCCACACCCCCCCGAGC	0.574			NA											13	258	---	---	---	---	NA	NA	NA	NA	NA
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr2:240954220_240954221insG	uc002vyn.2	-	5	684_685	c.604_605insC	c.(604-606)CACfs	p.H202fs	NDUFA10_uc010fzc.1_Frame_Shift_Ins_p.H242fs|NDUFA10_uc002vyo.1_Frame_Shift_Ins_p.H202fs	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535			NA											9	218	---	---	---	---	NA	NA	NA	NA	NA
CST1	1469	broad.mit.edu	37	20	23729753	23729754	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:23729753_23729754insC	uc002wtp.2	-	2	312_313	c.241_242insG	c.(241-243)GTGfs	p.V81fs		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	81						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					GAAGTAATTCACCCCCCCAACG	0.554			NA											9	331	---	---	---	---	NA	NA	NA	NA	NA
RPN2	6185	broad.mit.edu	37	20	35860725	35860726	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:35860725_35860726insC	uc002xgp.2	+	14	1912_1913	c.1608_1609insC	c.(1606-1611)AGGCCCfs	p.R536fs	RPN2_uc002xgq.2_Frame_Shift_Ins_p.R504fs	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	536_537	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CTGAGAAGAGGCCCCCCACCGT	0.574			NA											7	716	---	---	---	---	NA	NA	NA	NA	NA
RPRD1B	58490	broad.mit.edu	37	20	36676873	36676874	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:36676873_36676874insC	uc002xho.3	+	3	807_808	c.405_406insC	c.(403-408)CCTCCCfs	p.P135fs		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	135_136										pancreas(1)	1						CCAAGAGCCCTCCCCCCAAAGG	0.47			NA											14	361	---	---	---	---	NA	NA	NA	NA	NA
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:37146232_37146233insC	uc002xiw.2	+	8	1392_1393	c.1135_1136insC	c.(1135-1137)ACCfs	p.T379fs	RALGAPB_uc010zvz.1_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xix.2_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xiy.1_Frame_Shift_Ins_p.T379fs|RALGAPB_uc002xiz.2_Frame_Shift_Ins_p.T157fs|RALGAPB_uc002xja.1_Frame_Shift_Ins_p.T106fs	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TGTCAGTACCACCCCCCCACAT	0.446			NA											8	124	---	---	---	---	NA	NA	NA	NA	NA
RALGAPB	57148	broad.mit.edu	37	20	37203484	37203485	+	Frame_Shift_Ins	INS	-	-	C	rs138886522	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:37203484_37203485insC	uc002xiw.2	+	30	4616_4617	c.4359_4360insC	c.(4357-4362)AGTCCCfs	p.S1453fs	RALGAPB_uc002xix.2_Frame_Shift_Ins_p.S1450fs|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Frame_Shift_Ins_p.S1232fs	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1453_1454					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						ACTCCTACAGTCCCCCCCATGT	0.431			NA											10	173	---	---	---	---	NA	NA	NA	NA	NA
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:43881730_43881731insG	uc002xnm.1	-	3	328_329	c.306_307insC	c.(304-309)CCCAATfs	p.P102fs		NM_003064	NP_003055	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	102_103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535	GBM(64;162 1089 31780 33427 34538)		NA											14	329	---	---	---	---	NA	NA	NA	NA	NA
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:47989771_47989772insG	uc002xur.1	-	2	2489_2490	c.2325_2326insC	c.(2323-2328)CCCAAAfs	p.P775fs	KCNB1_uc002xus.1_Frame_Shift_Ins_p.P775fs	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	775_776	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545			NA											33	720	---	---	---	---	NA	NA	NA	NA	NA
GNAS	2778	broad.mit.edu	37	20	57478756	57478757	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr20:57478756_57478757insC	uc002xzw.2	+	5	2556_2557	c.2271_2272insC	c.(2269-2274)GTGCCCfs	p.V757fs	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Frame_Shift_Ins_p.V55fs|GNAS_uc002xzx.2_Frame_Shift_Ins_p.V55fs|GNAS_uc010gjr.2_Frame_Shift_Ins_p.V5fs|GNAS_uc002xzy.2_Frame_Shift_Ins_p.V40fs|GNAS_uc002yaa.2_Frame_Shift_Ins_p.V100fs|GNAS_uc010zzt.1_Frame_Shift_Ins_p.V115fs|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Frame_Shift_Ins_p.V5fs|GNAS_uc002yae.2_Frame_Shift_Ins_p.V39fs	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	114_115			P -> L (in AHO).		activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCAACCTGGTGCCCCCCGTGGA	0.559	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			8	201	---	---	---	---	NA	NA	NA	NA	NA
ITSN1	6453	broad.mit.edu	37	21	35122566	35122567	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:35122566_35122567insC	uc002yta.1	+	6	733_734	c.465_466insC	c.(463-468)GTGCCCfs	p.V155fs	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Frame_Shift_Ins_p.V155fs|ITSN1_uc010gmg.2_Frame_Shift_Ins_p.V118fs|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Frame_Shift_Ins_p.V155fs|ITSN1_uc010gmi.2_Frame_Shift_Ins_p.V118fs|ITSN1_uc010gmj.2_Frame_Shift_Ins_p.V39fs|ITSN1_uc002ysy.2_Frame_Shift_Ins_p.V155fs|ITSN1_uc002ysx.2_Frame_Shift_Ins_p.V118fs|ITSN1_uc002ytb.1_Frame_Shift_Ins_p.V155fs|ITSN1_uc002ytc.1_Frame_Shift_Ins_p.V155fs|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Frame_Shift_Ins_p.V118fs|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Frame_Shift_Ins_p.V155fs|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Frame_Shift_Ins_p.V89fs	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	155_156					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CAGCAGCTGTGCCCCCCCTGGC	0.525			NA											11	297	---	---	---	---	NA	NA	NA	NA	NA
DSCAM	1826	broad.mit.edu	37	21	41414355	41414356	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:41414355_41414356insG	uc002yyq.1	-	32	6080_6081	c.5628_5629insC	c.(5626-5631)CCCAAAfs	p.P1876fs	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1876_1877	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCTGAGGTTTGGGGGGAGATG	0.569	Melanoma(134;970 1778 1785 21664 32388)		NA											7	255	---	---	---	---	NA	NA	NA	NA	NA
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:41514614_41514615insG	uc002yyq.1	-	18	3728_3729	c.3276_3277insC	c.(3274-3279)CCCGAAfs	p.P1092fs	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1092_1093	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406	Melanoma(134;970 1778 1785 21664 32388)		NA											23	1211	---	---	---	---	NA	NA	NA	NA	NA
RSPH1	89765	broad.mit.edu	37	21	43913175	43913176	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:43913175_43913176insC	uc002zbg.2	-	2	173_174	c.68_69insG	c.(67-69)GGTfs	p.G23fs	SLC37A1_uc002zbh.1_5'Flank	NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	23	MORN 1.				meiosis	cytosol|nucleus				ovary(1)	1						CCTCATTCCGACCCCCCTCATA	0.406	Esophageal Squamous(23;63 706 6286 10288 12913)		NA											11	595	---	---	---	---	NA	NA	NA	NA	NA
KRTAP10-5	386680	broad.mit.edu	37	21	46000206	46000207	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr21:46000206_46000207insG	uc002zfl.1	-	1	275_276	c.249_250insC	c.(247-252)CCCTGCfs	p.P83fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	83_84	22 X 5 AA repeats of C-C-X(3).					keratin filament					0						gcctgctggcagggggaggagg	0.292			NA											10	339	---	---	---	---	NA	NA	NA	NA	NA
TPST2	8459	broad.mit.edu	37	22	26932298	26932299	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:26932298_26932299insG	uc003acv.2	-	3	1164_1165	c.996_997insC	c.(994-999)CCCAACfs	p.P332fs	TPST2_uc003acw.2_Frame_Shift_Ins_p.P332fs|TPST2_uc003acx.2_Frame_Shift_Ins_p.P332fs	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	332_333	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						TTGCCATAGTTGGGGGGGTTTG	0.584			NA											8	79	---	---	---	---	NA	NA	NA	NA	NA
THOC5	8563	broad.mit.edu	37	22	29925230	29925231	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:29925230_29925231insG	uc003afr.2	-	10	1183	c.848_splice	c.e10-1	p.D283_splice	THOC5_uc003afq.2_5'Flank|THOC5_uc003afs.2_Splice_Site_p.D283_splice|THOC5_uc003aft.2_Splice_Site_p.D283_splice|THOC5_uc003afu.2_Splice_Site_p.D283_splice|THOC5_uc010gvo.2_Splice_Site_p.N27_splice|THOC5_uc003afv.1_Intron	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5						intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ACGTCTTATCTGGGGGGCAAGA	0.535			NA											7	281	---	---	---	---	NA	NA	NA	NA	NA
MTMR3	8897	broad.mit.edu	37	22	30408493	30408494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:30408493_30408494insC	uc003agv.3	+	13	1586_1587	c.1258_1259insC	c.(1258-1260)ACCfs	p.T420fs	MTMR3_uc003agu.3_Frame_Shift_Ins_p.T420fs|MTMR3_uc003agw.3_Frame_Shift_Ins_p.T420fs	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	420	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTGGGACCGCACCCCCCAGATT	0.545			NA											16	1523	---	---	---	---	NA	NA	NA	NA	NA
TNRC6B	23112	broad.mit.edu	37	22	40708590	40708591	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:40708590_40708591insG	uc011aor.1	+	18	4728_4729	c.4517_4518insG	c.(4516-4518)CTGfs	p.L1506fs	TNRC6B_uc003aym.2_Frame_Shift_Ins_p.L702fs|TNRC6B_uc003ayn.3_Frame_Shift_Ins_p.L1396fs|TNRC6B_uc003ayo.2_Frame_Shift_Ins_p.L1253fs	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1506					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GGAAGTGTGCTGGGGGGTACAG	0.48			NA											10	1019	---	---	---	---	NA	NA	NA	NA	NA
TCF20	6942	broad.mit.edu	37	22	42610947	42610948	+	Frame_Shift_Ins	INS	-	-	G	rs138734341		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr22:42610947_42610948insG	uc003bcj.1	-	1	498_499	c.364_365insC	c.(364-366)CAGfs	p.Q122fs	TCF20_uc003bck.1_Frame_Shift_Ins_p.Q122fs|TCF20_uc003bnt.2_Frame_Shift_Ins_p.Q122fs	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	122				Q -> R (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCTGCTCCCCTGGGGGGGTCCA	0.564			NA											14	611	---	---	---	---	NA	NA	NA	NA	NA
MLH1	4292	broad.mit.edu	37	3	37070348	37070349	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:37070348_37070349insC	uc003cgl.2	+	13	1543_1544	c.1483_1484insC	c.(1483-1485)ACCfs	p.T495fs	MLH1_uc011aye.1_Frame_Shift_Ins_p.T254fs|MLH1_uc011ayb.1_Frame_Shift_Ins_p.T254fs|MLH1_uc010hge.2_Frame_Shift_Ins_p.T495fs|MLH1_uc003cgn.3_Frame_Shift_Ins_p.T254fs|MLH1_uc011ayc.1_Frame_Shift_Ins_p.T397fs|MLH1_uc011ayd.1_Frame_Shift_Ins_p.T254fs|MLH1_uc003cgo.2_Frame_Shift_Ins_p.T254fs|MLH1_uc010hgi.1_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgj.1_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgk.2_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgl.1_Frame_Shift_Ins_p.T70fs|MLH1_uc010hgn.2_Frame_Shift_Ins_p.T137fs|MLH1_uc010hgm.2_RNA|MLH1_uc010hgo.2_Frame_Shift_Ins_p.T137fs	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	495	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.T495A(1)|p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGCAGCTTGTACCCCCCGGAGA	0.47			1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				7	572	---	---	---	---	NA	NA	NA	NA	NA
TRAK1	22906	broad.mit.edu	37	3	42242449	42242450	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:42242449_42242450insC	uc003cky.2	+	12	1546_1547	c.1330_1331insC	c.(1330-1332)ACCfs	p.T444fs	TRAK1_uc011azh.1_Frame_Shift_Ins_p.T444fs|TRAK1_uc011azi.1_Frame_Shift_Ins_p.T444fs|TRAK1_uc003ckz.3_Frame_Shift_Ins_p.T370fs|TRAK1_uc011azj.1_Frame_Shift_Ins_p.T370fs|TRAK1_uc003cla.2_Frame_Shift_Ins_p.T386fs	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	444	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						CTGCGTCAGCACCCCCCGGTCC	0.594	GBM(44;195 884 22595 31865 41850)		NA											8	201	---	---	---	---	NA	NA	NA	NA	NA
PFKFB4	5210	broad.mit.edu	37	3	48573780	48573781	+	Frame_Shift_Ins	INS	-	-	G	rs142200739		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:48573780_48573781insG	uc003ctv.2	-	8	765_766	c.748_749insC	c.(748-750)CGCfs	p.R250fs	PFKFB4_uc003ctw.2_Frame_Shift_Ins_p.R59fs|PFKFB4_uc010hkc.2_Frame_Shift_Ins_p.R250fs|PFKFB4_uc003ctx.2_Frame_Shift_Ins_p.R207fs|PFKFB4_uc010hkb.2_Frame_Shift_Ins_p.R250fs|PFKFB4_uc011bbm.1_Frame_Shift_Ins_p.R239fs|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	250	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GTAGATGGAGCGGGGGGTCACG	0.619			NA											12	610	---	---	---	---	NA	NA	NA	NA	NA
RBM6	10180	broad.mit.edu	37	3	50005144	50005145	+	Frame_Shift_Ins	INS	-	-	G	rs141234052		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:50005144_50005145insG	uc003cyc.2	+	3	419_420	c.286_287insG	c.(286-288)AGGfs	p.R96fs	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	96					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ACATGATTTCAGGGGGGGAGAT	0.495			NA											7	221	---	---	---	---	NA	NA	NA	NA	NA
KCTD6	200845	broad.mit.edu	37	3	58486771	58486772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:58486771_58486772insG	uc003dkj.3	+	3	243_244	c.126_127insG	c.(124-129)TTTGGGfs	p.F42fs	KCTD6_uc003dki.3_Frame_Shift_Ins_p.F42fs|KCTD6_uc003dkk.3_Frame_Shift_Ins_p.F42fs	NM_001128214	NP_001121686	Q8NC69	KCTD6_HUMAN	potassium channel tetramerisation domain	42_43	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		GAGCTATGTTTGGGGGGGACTT	0.465			NA											15	353	---	---	---	---	NA	NA	NA	NA	NA
ATXN7	6314	broad.mit.edu	37	3	63981831	63981832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:63981831_63981832insC	uc003dlw.3	+	12	2886_2887	c.2333_2334insC	c.(2332-2334)GGCfs	p.G778fs	ATXN7_uc003dlv.2_Frame_Shift_Ins_p.G778fs|ATXN7_uc010hnv.2_Frame_Shift_Ins_p.G778fs|ATXN7_uc011bfn.1_Frame_Shift_Ins_p.G633fs	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	778	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TCAGGGAGGGGCCCCCCCACCG	0.545			NA											10	167	---	---	---	---	NA	NA	NA	NA	NA
KIAA2018	205717	broad.mit.edu	37	3	113375177	113375178	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:113375177_113375178insG	uc003eam.2	-	7	5762_5763	c.5351_5352insC	c.(5350-5352)CCAfs	p.P1784fs	KIAA2018_uc003eal.2_Frame_Shift_Ins_p.P1728fs	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1784					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GGTCAATTGGTGGGGGGCCAGT	0.426			NA											7	587	---	---	---	---	NA	NA	NA	NA	NA
IGSF11	152404	broad.mit.edu	37	3	118647520	118647521	+	Frame_Shift_Ins	INS	-	-	G	rs145433873	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:118647520_118647521insG	uc003ebw.2	-	3	506_507	c.259_260insC	c.(259-261)CGGfs	p.R87fs	IGSF11_uc011biv.1_Frame_Shift_Ins_p.R87fs|IGSF11_uc003ebx.2_Frame_Shift_Ins_p.R87fs|IGSF11_uc003eby.2_Frame_Shift_Ins_p.R86fs|IGSF11_uc003ebz.2_Frame_Shift_Ins_p.R86fs|IGSF11_uc010hqs.2_Frame_Shift_Ins_p.R86fs	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	87	Ig-like V-type.|Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						ACCGTGGAACCGGGGGGCACCA	0.465			NA											7	660	---	---	---	---	NA	NA	NA	NA	NA
GPR156	165829	broad.mit.edu	37	3	119885959	119885960	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:119885959_119885960insC	uc011bjf.1	-	9	2364_2365	c.2364_2365insG	c.(2362-2367)GGGCTGfs	p.G788fs	GPR156_uc011bjg.1_Frame_Shift_Ins_p.G784fs	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	788_789	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		CAGGAAGCCAGCCCCCCAGTAG	0.55			NA											7	411	---	---	---	---	NA	NA	NA	NA	NA
GRK7	131890	broad.mit.edu	37	3	141535707	141535708	+	Frame_Shift_Ins	INS	-	-	G	rs149574289		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:141535707_141535708insG	uc011bnd.1	+	4	1561_1562	c.1477_1478insG	c.(1477-1479)CGGfs	p.R493fs		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	493	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CTCTGAGGTTCGGGGGGTGGAA	0.46			NA											11	826	---	---	---	---	NA	NA	NA	NA	NA
MED12L	116931	broad.mit.edu	37	3	150877785	150877786	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:150877785_150877786insC	uc003eyp.2	+	7	1042_1043	c.1004_1005insC	c.(1003-1005)GGCfs	p.G335fs	MED12L_uc011bnz.1_Intron|MED12L_uc003eyn.2_Frame_Shift_Ins_p.G335fs|MED12L_uc003eyo.2_Frame_Shift_Ins_p.G335fs	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	335					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCCAGCCCTGGCCCCCCCGGCC	0.584			NA											8	105	---	---	---	---	NA	NA	NA	NA	NA
GOLIM4	27333	broad.mit.edu	37	3	167728581	167728581	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:167728581delT	uc003ffe.2	-	15	2235	c.1891delA	c.(1891-1893)AGGfs	p.R631fs	GOLIM4_uc011bpe.1_Frame_Shift_Del_p.R632fs|GOLIM4_uc011bpf.1_Frame_Shift_Del_p.R604fs|GOLIM4_uc011bpg.1_Frame_Shift_Del_p.R603fs	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	631	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TCCAGTTCCCTTTTTTTCTCT	0.358			NA											10	567	---	---	---	---	NA	NA	NA	NA	NA
SAMD7	344658	broad.mit.edu	37	3	169646267	169646268	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:169646267_169646268insG	uc003fgd.2	+	7	1209_1210	c.942_943insG	c.(940-945)ATTGGGfs	p.I314fs	SAMD7_uc003fge.2_Frame_Shift_Ins_p.I314fs|SAMD7_uc011bpo.1_Frame_Shift_Ins_p.I215fs	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	314_315										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGTTACAATTGGGGGGAATCT	0.381			NA											8	531	---	---	---	---	NA	NA	NA	NA	NA
FNDC3B	64778	broad.mit.edu	37	3	172096209	172096210	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:172096209_172096210insC	uc003fhy.2	+	24	3330_3331	c.3158_3159insC	c.(3157-3159)GTCfs	p.V1053fs	FNDC3B_uc003fhz.3_Frame_Shift_Ins_p.V1053fs	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1053						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACCAAAAGTGTCCCCCCCACCA	0.47			NA											7	182	---	---	---	---	NA	NA	NA	NA	NA
TBL1XR1	79718	broad.mit.edu	37	3	176769341	176769342	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:176769341_176769342insT	uc003fiw.3	-	5	637_638	c.377_378insA	c.(376-378)AATfs	p.N126fs	TBL1XR1_uc003fix.3_Frame_Shift_Ins_p.N126fs|TBL1XR1_uc011bpz.1_Translation_Start_Site|TBL1XR1_uc003fiy.2_Frame_Shift_Ins_p.N126fs	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	126					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TGTTTTCTCCATTTTTTGCAGA	0.416			NA											7	208	---	---	---	---	NA	NA	NA	NA	NA
ABCC5	10057	broad.mit.edu	37	3	183700629	183700630	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:183700629_183700630insC	uc003fmg.2	-	6	922_923	c.757_758insG	c.(757-759)GCCfs	p.A253fs	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Frame_Shift_Ins_p.A253fs	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	253	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGTTAGGATGGCCCCCCGCAAG	0.515			NA											7	331	---	---	---	---	NA	NA	NA	NA	NA
FETUB	26998	broad.mit.edu	37	3	186370136	186370137	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:186370136_186370137insC	uc010hyq.2	+	8	1126_1127	c.865_866insC	c.(865-867)ACCfs	p.T289fs	FETUB_uc011brz.1_Frame_Shift_Ins_p.T141fs|FETUB_uc003fqn.2_Frame_Shift_Ins_p.T289fs|FETUB_uc003fqo.2_Frame_Shift_Ins_p.T184fs|FETUB_uc010hyr.2_Frame_Shift_Ins_p.T252fs|FETUB_uc010hys.2_Frame_Shift_Ins_p.T141fs|FETUB_uc003fqp.3_Frame_Shift_Ins_p.T224fs	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	289						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GCAGAAAAACACCCCCCCAACA	0.495			NA											22	305	---	---	---	---	NA	NA	NA	NA	NA
KIAA0226	9711	broad.mit.edu	37	3	197427914	197427915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr3:197427914_197427915insG	uc003fyc.2	-	7	1013_1014	c.830_831insC	c.(829-831)CCAfs	p.P277fs	KIAA0226_uc003fyd.3_Frame_Shift_Ins_p.P217fs|KIAA0226_uc003fye.1_5'UTR|KIAA0226_uc003fyf.2_Frame_Shift_Ins_p.P110fs|KIAA0226_uc003fyg.2_Frame_Shift_Ins_p.P270fs	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	277	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		AGACTGAAACTGGGGGGGCTTG	0.554	Esophageal Squamous(3;167 355 3763 15924)		NA											7	214	---	---	---	---	NA	NA	NA	NA	NA
EVC	2121	broad.mit.edu	37	4	5785361	5785362	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:5785361_5785362insC	uc003gil.1	+	12	1830_1831	c.1646_1647insC	c.(1645-1647)CTCfs	p.L549fs	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	549					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				ATGACTGGCCTCCCCCCGGAAG	0.584			NA											12	670	---	---	---	---	NA	NA	NA	NA	NA
STIM2	57620	broad.mit.edu	37	4	27019446	27019447	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:27019446_27019447insC	uc003gsh.3	+	12	2104_2105	c.1888_1889insC	c.(1888-1890)GCCfs	p.A630fs	STIM2_uc003gsg.3_Frame_Shift_Ins_p.A622fs|STIM2_uc010iex.2_Frame_Shift_Ins_p.A622fs|STIM2_uc010iey.2_Frame_Shift_Ins_p.A246fs	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	535	Cytoplasmic (Potential).|His/Pro-rich.				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TGCTCCACACGCCCCCCACCCG	0.619			NA											7	509	---	---	---	---	NA	NA	NA	NA	NA
FRAS1	80144	broad.mit.edu	37	4	79173612	79173613	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:79173612_79173613insC	uc003hlb.2	+	5	816_817	c.376_377insC	c.(376-378)ACCfs	p.T126fs	FRAS1_uc003hkw.2_Frame_Shift_Ins_p.T126fs|FRAS1_uc003hky.1_5'UTR|FRAS1_uc003hkz.2_5'Flank	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	126	VWFC 2.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AGTCCGATGTACCCCCCAACCA	0.525			NA											12	385	---	---	---	---	NA	NA	NA	NA	NA
WDFY3	23001	broad.mit.edu	37	4	85611708	85611709	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:85611708_85611709delCA	uc003hpd.2	-	61	9721_9722	c.9313_9314delTG	c.(9313-9315)TGGfs	p.W3105fs		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3105	WD 1.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCCCATCTCCCACACACACACA	0.51			NA											9	425	---	---	---	---	NA	NA	NA	NA	NA
ABCG2	9429	broad.mit.edu	37	4	89052270	89052271	+	Frame_Shift_Ins	INS	-	-	T	rs150450599	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:89052270_89052271insT	uc003hrg.2	-	5	966_967	c.473_474insA	c.(472-474)AACfs	p.N158fs	ABCG2_uc003hrh.2_Frame_Shift_Ins_p.N158fs|ABCG2_uc003hrf.2_Frame_Shift_Ins_p.N28fs	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	158	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TAATCCGTTCGTTTTTTTCATG	0.426			NA											9	1129	---	---	---	---	NA	NA	NA	NA	NA
HPGDS	27306	broad.mit.edu	37	4	95223320	95223321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:95223320_95223321insC	uc003hte.1	-	5	502_503	c.411_412insG	c.(409-414)GGGAGAfs	p.G137fs		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	137_138	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	AGCCATTCTCTCCCCCCTAAAT	0.351	Colon(86;1802 1843 17863 46794)		NA											11	1050	---	---	---	---	NA	NA	NA	NA	NA
UNC5C	8633	broad.mit.edu	37	4	96140293	96140294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:96140293_96140294insG	uc003htp.1	-	9	1625_1626	c.1471_1472insC	c.(1471-1473)CAAfs	p.Q491fs	UNC5C_uc010ilc.1_Frame_Shift_Ins_p.Q510fs|UNC5C_uc003htq.2_Frame_Shift_Ins_p.Q510fs	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	491	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAGGTCATCTTGGGGGGTGACA	0.505			NA											7	552	---	---	---	---	NA	NA	NA	NA	NA
CFI	3426	broad.mit.edu	37	4	110662158	110662159	+	Frame_Shift_Ins	INS	-	-	C	rs7437875	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:110662158_110662159insC	uc003hzr.3	-	13	1850_1851	c.1642_1643insG	c.(1642-1644)GAAfs	p.E548fs	CFI_uc003hzq.2_Frame_Shift_Ins_p.E345fs|CFI_uc011cft.1_Frame_Shift_Ins_p.E556fs|CFI_uc003hzs.3_Frame_Shift_Ins_p.E541fs	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	548	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TCCACAGTTTTCCCCCCAACTC	0.465			NA											14	566	---	---	---	---	NA	NA	NA	NA	NA
RRH	10692	broad.mit.edu	37	4	110763720	110763721	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:110763720_110763721insC	uc003hzv.2	+	6	850_851	c.816_817insC	c.(814-819)CCTCCCfs	p.P272fs		NM_006583	NP_006574	O14718	OPSX_HUMAN	peropsin	272_273	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		AGAAGATTCCTCCCCCCATGGC	0.416			NA											8	585	---	---	---	---	NA	NA	NA	NA	NA
ANKRD50	57182	broad.mit.edu	37	4	125590618	125590619	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:125590618_125590619insC	uc003ifg.3	-	3	4079_4080	c.3813_3814insG	c.(3811-3816)GGGAAAfs	p.G1271fs	ANKRD50_uc011cgo.1_Frame_Shift_Ins_p.G1092fs|ANKRD50_uc010inw.2_Frame_Shift_Ins_p.G1271fs	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1271_1272	Ser-rich.									central_nervous_system(1)	1						TTTTCTGATTTCCCCCCTTTAC	0.391			NA											11	650	---	---	---	---	NA	NA	NA	NA	NA
SETD7	80854	broad.mit.edu	37	4	140432891	140432892	+	Frame_Shift_Ins	INS	-	-	G	rs35259575		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:140432891_140432892insG	uc003ihw.2	-	8	1312_1313	c.1026_1027insC	c.(1024-1029)CCCGGGfs	p.P342fs		NM_030648	NP_085151	Q8WTS6	SETD7_HUMAN	SET domain-containing protein 7	342_343					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.156)					CCACTCTTCCCGGGGGGGCTGT	0.609			NA											13	136	---	---	---	---	NA	NA	NA	NA	NA
SH3D19	152503	broad.mit.edu	37	4	152095943	152095944	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:152095943_152095944insG	uc010ipl.1	-	7	1662_1663	c.572_573insC	c.(571-573)CCAfs	p.P191fs	SH3D19_uc003imc.2_Frame_Shift_Ins_p.P191fs|SH3D19_uc003ime.2_Frame_Shift_Ins_p.P191fs|SH3D19_uc010ipm.2_Frame_Shift_Ins_p.P191fs	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	191	Pro-rich.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				GAACTGGAACTGGGGGGTTGGC	0.559			NA											7	909	---	---	---	---	NA	NA	NA	NA	NA
FGG	2266	broad.mit.edu	37	4	155526058	155526059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:155526058_155526059insC	uc003ioj.2	-	9	1430_1431	c.1289_1290insG	c.(1288-1290)GGAfs	p.G430fs	FGG_uc003iog.2_Frame_Shift_Ins_p.G430fs|FGG_uc003ioh.2_Frame_Shift_Ins_p.G438fs|FGG_uc010ipx.2_Frame_Shift_Ins_p.G258fs|FGG_uc010ipy.2_Frame_Shift_Ins_p.G141fs|FGG_uc003ioi.2_Frame_Shift_Ins_p.G141fs|FGG_uc003iok.2_Frame_Shift_Ins_p.G438fs	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	430	Platelet aggregation and Staphylococcus clumping.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CCTGTTTGGCTCCCCCCAGGTG	0.45			NA											10	697	---	---	---	---	NA	NA	NA	NA	NA
ODZ3	55714	broad.mit.edu	37	4	183609358	183609359	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:183609358_183609359insG	uc003ivd.1	+	11	2112_2113	c.2075_2076insG	c.(2074-2076)ATGfs	p.M692fs	ODZ3_uc003ive.1_Frame_Shift_Ins_p.M98fs	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	692	Extracellular (Potential).|EGF-like 6.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGCGTTTGCATGGGGGGGACGT	0.589			NA											20	494	---	---	---	---	NA	NA	NA	NA	NA
SORBS2	8470	broad.mit.edu	37	4	186515043	186515044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:186515043_186515044insC	uc003iyl.2	-	19	3988_3989	c.3130_3131insG	c.(3130-3132)GAAfs	p.E1044fs	SORBS2_uc003iyh.2_Frame_Shift_Ins_p.E768fs|SORBS2_uc011ckw.1_Frame_Shift_Ins_p.E605fs|SORBS2_uc003iyi.2_Frame_Shift_Ins_p.E675fs|SORBS2_uc011ckx.1_Frame_Shift_Ins_p.E610fs|SORBS2_uc003iyk.2_Frame_Shift_Ins_p.E588fs|SORBS2_uc003iym.2_Frame_Shift_Ins_p.E1144fs|SORBS2_uc003iyn.1_Frame_Shift_Ins_p.E635fs|SORBS2_uc011cku.1_Frame_Shift_Ins_p.E436fs|SORBS2_uc011ckv.1_Frame_Shift_Ins_p.E948fs|SORBS2_uc003iyd.2_Frame_Shift_Ins_p.E743fs|SORBS2_uc003iye.2_Frame_Shift_Ins_p.E617fs|SORBS2_uc003iya.2_Frame_Shift_Ins_p.E564fs|SORBS2_uc003iyb.2_Frame_Shift_Ins_p.E517fs|SORBS2_uc003iyc.2_Frame_Shift_Ins_p.E497fs|SORBS2_uc003iyg.2_Frame_Shift_Ins_p.E1158fs|SORBS2_uc003iyf.2_Frame_Shift_Ins_p.E580fs	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	1044	SH3 3.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TACTTACGGTTCCCCCCCACCT	0.356	Esophageal Squamous(153;41 2433 9491 36028)		NA											8	167	---	---	---	---	NA	NA	NA	NA	NA
TLR3	7098	broad.mit.edu	37	4	186997804	186997805	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr4:186997804_186997805insG	uc003iyq.2	+	2	132_133	c.31_32insG	c.(31-33)TGGfs	p.W11fs		NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	11					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TATCTACTTTTGGGGGGGCCTT	0.446			NA											7	252	---	---	---	---	NA	NA	NA	NA	NA
C7	730	broad.mit.edu	37	5	40931243	40931243	+	Splice_Site	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:40931243delT	uc003jmh.2	+	3	252	c.138_splice	c.e3+2	p.Q46_splice	C7_uc011cpn.1_Splice_Site	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AAGACTCAGGTAGGACCATGC	0.408			NA											45	119	---	---	---	---	NA	NA	NA	NA	NA
C6	729	broad.mit.edu	37	5	41159256	41159257	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:41159256_41159257insG	uc003jmk.2	-	12	1993_1994	c.1783_1784insC	c.(1783-1785)CAAfs	p.Q595fs	C6_uc003jml.1_Frame_Shift_Ins_p.Q595fs	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	595	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCCTCCTCGTTGGGGGGCAGGA	0.5			NA											7	413	---	---	---	---	NA	NA	NA	NA	NA
C6	729	broad.mit.edu	37	5	41181559	41181560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:41181559_41181560insC	uc003jmk.2	-	7	1038_1039	c.828_829insG	c.(826-831)GGGAGCfs	p.G276fs	C6_uc003jml.1_Frame_Shift_Ins_p.G276fs	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	276_277	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTGAAAGAGCTCCCCCCCTGAC	0.376			NA											10	299	---	---	---	---	NA	NA	NA	NA	NA
MOCS2	4338	broad.mit.edu	37	5	52402939	52402940	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:52402939_52402940insG	uc011cqf.1	-	3	291_292	c.252_253insC	c.(250-255)CCCATTfs	p.P84fs	MOCS2_uc003joz.2_Frame_Shift_Ins_p.P22fs|uc003jpb.1_5'Flank	NM_176806	NP_789776	O96033	MOC2A_HUMAN	molybdopterin synthase small subunit MOCS2A	84_85					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding				0		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				CCTCCACTAATGGGGGGGATAA	0.426			NA											7	151	---	---	---	---	NA	NA	NA	NA	NA
MAP1B	4131	broad.mit.edu	37	5	71495076	71495077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:71495076_71495077insC	uc003kbw.3	+	5	6135_6136	c.5894_5895insC	c.(5893-5895)AGCfs	p.S1965fs	MAP1B_uc010iyw.1_Frame_Shift_Ins_p.S1982fs|MAP1B_uc010iyx.1_Frame_Shift_Ins_p.S1839fs|MAP1B_uc010iyy.1_Frame_Shift_Ins_p.S1839fs	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1965	MAP1B 6.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCACCAGCCCCCCCGAAG	0.485	Melanoma(17;367 822 11631 31730 47712)		NA											14	440	---	---	---	---	NA	NA	NA	NA	NA
PCSK1	5122	broad.mit.edu	37	5	95746639	95746640	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:95746639_95746640insC	uc003kls.1	-	8	1139_1140	c.933_934insG	c.(931-936)GGGCGTfs	p.G311fs	PCSK1_uc010jbi.1_Intron	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	311_312	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTCCCTGACGCCCCCCGTTTC	0.53			NA											7	408	---	---	---	---	NA	NA	NA	NA	NA
CHD1	1105	broad.mit.edu	37	5	98193965	98193966	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:98193965_98193966insT	uc003knf.2	-	34	4853_4854	c.4705_4706insA	c.(4705-4707)AGTfs	p.S1569fs	CHD1_uc010jbn.2_Frame_Shift_Ins_p.S295fs	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1569					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CCTGGAATCACTTTTTTTGTAA	0.406			NA											7	754	---	---	---	---	NA	NA	NA	NA	NA
FBN2	2201	broad.mit.edu	37	5	127610310	127610311	+	Frame_Shift_Ins	INS	-	-	C	rs151053868		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:127610310_127610311insC	uc003kuu.2	-	60	8098_8099	c.7659_7660insG	c.(7657-7662)GGGTTTfs	p.G2553fs		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2553_2554	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTACAGGTAAACCCCCCCAGGG	0.421			NA											7	439	---	---	---	---	NA	NA	NA	NA	NA
FBN2	2201	broad.mit.edu	37	5	127648336	127648337	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:127648336_127648337insG	uc003kuu.2	-	37	5307_5308	c.4868_4869insC	c.(4867-4869)CCTfs	p.P1623fs		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1623	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGCTATTGACAGGGGGGCATGT	0.505			NA											9	1132	---	---	---	---	NA	NA	NA	NA	NA
ARAP3	64411	broad.mit.edu	37	5	141051692	141051693	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:141051692_141051693insC	uc003llm.2	-	10	1639_1640	c.1561_1562insG	c.(1561-1563)GTGfs	p.V521fs	ARAP3_uc011dbe.1_Frame_Shift_Ins_p.V183fs|ARAP3_uc003lln.2_Frame_Shift_Ins_p.V443fs|ARAP3_uc003llo.1_Frame_Shift_Ins_p.V521fs	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	521	Arf-GAP.|C4-type.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GCAGATGACCACCCCCAAATTG	0.604			NA											8	1085	---	---	---	---	NA	NA	NA	NA	NA
FAT2	2196	broad.mit.edu	37	5	150922939	150922940	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr5:150922939_150922940insG	uc003lue.3	-	9	7761_7762	c.7748_7749insC	c.(7747-7749)CCAfs	p.P2583fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2583	Extracellular (Potential).|Cadherin 22.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTTGAACTGTGGGGGGTTGTC	0.47			NA											8	438	---	---	---	---	NA	NA	NA	NA	NA
EXOC2	55770	broad.mit.edu	37	6	637793	637794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:637793_637794insG	uc003mtd.2	-	2	159_160	c.25_26insC	c.(25-27)CTTfs	p.L9fs	EXOC2_uc003mte.2_Frame_Shift_Ins_p.L9fs|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	9	IPT/TIG.				exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GCCGGTCACAAGGGGGGGTTGT	0.485			NA											10	261	---	---	---	---	NA	NA	NA	NA	NA
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:13206134_13206135insG	uc010jpc.2	+	8	1084_1085	c.752_753insG	c.(751-753)GTGfs	p.V251fs	PHACTR1_uc011dir.1_Frame_Shift_Ins_p.V320fs|PHACTR1_uc003nag.1_Frame_Shift_Ins_p.V251fs|PHACTR1_uc003nah.1_Frame_Shift_Ins_p.V251fs	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599			NA											16	328	---	---	---	---	NA	NA	NA	NA	NA
KIF13A	63971	broad.mit.edu	37	6	17837307	17837308	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:17837307_17837308insC	uc003ncg.3	-	11	1061_1062	c.956_957insG	c.(955-957)GGCfs	p.G319fs	KIF13A_uc003ncf.2_Frame_Shift_Ins_p.G319fs|KIF13A_uc003nch.3_Frame_Shift_Ins_p.G319fs|KIF13A_uc003nci.3_Frame_Shift_Ins_p.G319fs|KIF13A_uc003ncj.2_5'UTR	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	319					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTTGGCTGTTGCCCCCCAAGTT	0.45			NA											9	225	---	---	---	---	NA	NA	NA	NA	NA
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:24205282_24205283insC	uc003ndx.2	-	8	1272_1273	c.970_971insG	c.(970-972)GCAfs	p.A324fs	DCDC2_uc003ndy.2_Frame_Shift_Ins_p.A324fs|DCDC2_uc003ndw.2_Frame_Shift_Ins_p.A75fs	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411			NA											38	2550	---	---	---	---	NA	NA	NA	NA	NA
C6orf134	79969	broad.mit.edu	37	6	30610713	30610714	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:30610713_30610714insC	uc003nqu.2	+	10	943_944	c.893_894insC	c.(892-894)TGCfs	p.C298fs	C6orf134_uc003nqr.3_Frame_Shift_Ins_p.C298fs|C6orf134_uc003rdc.2_Frame_Shift_Ins_p.C298fs|C6orf134_uc003nqs.3_Frame_Shift_Ins_p.C275fs|C6orf134_uc003rdd.2_Frame_Shift_Ins_p.C275fs|C6orf134_uc003nqt.2_Intron|C6orf134_uc011dmm.1_Frame_Shift_Ins_p.C263fs|C6orf134_uc003nqv.2_Frame_Shift_Ins_p.C286fs	NM_024909	NP_079185	Q5SQI0	ATAT_HUMAN	hypothetical protein LOC79969 isoform 2	298							tubulin N-acetyltransferase activity				0						TTGCGCCTCTGCCCCCCACACC	0.658			NA											7	244	---	---	---	---	NA	NA	NA	NA	NA
BAT1	7919	broad.mit.edu	37	6	31500690	31500691	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:31500690_31500691insG	uc003ntt.2	-	7	1367	c.736_splice	c.e7-1	p.P246_splice	BAT1_uc003ntq.2_5'Flank|BAT1_uc003ntr.2_Frame_Shift_Ins_p.Q52fs|BAT1_uc003nts.2_Splice_Site_p.P246_splice|BAT1_uc011dnn.1_Splice_Site_p.P168_splice|BAT1_uc003ntu.2_Splice_Site_p.P246_splice|BAT1_uc003ntv.2_Splice_Site_p.P246_splice	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1						intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						CTCCATTGGCTgggggggagga	0.396			NA											9	114	---	---	---	---	NA	NA	NA	NA	NA
HLA-DOA	3111	broad.mit.edu	37	6	32975278	32975279	+	Frame_Shift_Ins	INS	-	-	G	rs115076830	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:32975278_32975279insG	uc003ocr.2	-	3	498_499	c.422_423insC	c.(421-423)CCTfs	p.P141fs	HLA-DOA_uc010juj.2_Frame_Shift_Ins_p.P111fs|HLA-DOA_uc010jui.2_Frame_Shift_Ins_p.P141fs	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	141	Extracellular (Potential).|Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						TATTGATCACAGGGGGGAAGAT	0.584			NA											7	688	---	---	---	---	NA	NA	NA	NA	NA
VPS52	6293	broad.mit.edu	37	6	33219719	33219720	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:33219719_33219720insG	uc003odm.1	-	18	2033_2034	c.1823_1824insC	c.(1822-1824)CCTfs	p.P608fs	VPS52_uc003odn.1_Frame_Shift_Ins_p.P419fs	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	608					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						AACCCCCAAAAGGGGGAGACAG	0.48			NA											31	187	---	---	---	---	NA	NA	NA	NA	NA
MAPK14	1432	broad.mit.edu	37	6	36068005	36068006	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:36068005_36068006insC	uc003olp.2	+	9	1204_1205	c.723_724insC	c.(721-726)ACACCCfs	p.T241fs	MAPK14_uc003olo.2_Intron|MAPK14_uc003olq.2_Intron|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Intron	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	241_242	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						TGACAGGAACACCCCCCGCTTA	0.426	Pancreas(20;8 363 26997 32430 36377 43317 49243 50560 51947)|Colon(176;951 1093 20177 30266 32328 34418 35271 44052 51610)		NA											16	517	---	---	---	---	NA	NA	NA	NA	NA
TRERF1	55809	broad.mit.edu	37	6	42237162	42237163	+	Frame_Shift_Ins	INS	-	-	G	rs140151920	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:42237162_42237163insG	uc003osd.2	-	5	729_730	c.166_167insC	c.(166-168)CACfs	p.H56fs	TRERF1_uc011duq.1_Frame_Shift_Ins_p.H56fs|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Frame_Shift_Ins_p.H56fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	56					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TTGAGGGAAGTGGGGGGAGATT	0.589			NA											7	178	---	---	---	---	NA	NA	NA	NA	NA
PTK7	5754	broad.mit.edu	37	6	43111195	43111196	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:43111195_43111196insC	uc003oub.1	+	14	2286_2287	c.2088_2089insC	c.(2086-2091)CCTCCCfs	p.P696fs	PTK7_uc003ouc.1_Frame_Shift_Ins_p.P640fs|PTK7_uc003oud.1_Frame_Shift_Ins_p.P656fs|PTK7_uc003oue.1_Frame_Shift_Ins_p.P566fs|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Frame_Shift_Ins_p.P704fs|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	696_697	Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CTGGCAGCCCTCCCCCCTACAA	0.604			NA									OREG0017450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	205	---	---	---	---	NA	NA	NA	NA	NA
TNFRSF21	27242	broad.mit.edu	37	6	47253988	47253989	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:47253988_47253989insG	uc003oyv.2	-	2	872_873	c.439_440insC	c.(439-441)CATfs	p.H147fs		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	147	Extracellular (Potential).|TNFR-Cys 3.				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			ACACACCGTATGGGGGGCACAG	0.554			NA											9	765	---	---	---	---	NA	NA	NA	NA	NA
HCRTR2	3062	broad.mit.edu	37	6	55039410	55039411	+	Frame_Shift_Ins	INS	-	-	C	rs76774128		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:55039410_55039411insC	uc003pcl.2	+	1	340_341	c.25_26insC	c.(25-27)TCCfs	p.S9fs	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzu.1_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	9	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATTGGAGGACTCCCCCCCTTGT	0.564			NA											10	234	---	---	---	---	NA	NA	NA	NA	NA
HTR1E	3354	broad.mit.edu	37	6	87725846	87725847	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:87725846_87725847insC	uc003pli.2	+	2	1497_1498	c.794_795insC	c.(793-795)ATCfs	p.I265fs		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	265	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCCATCAGGATCCCCCCCTTCG	0.51			NA											8	401	---	---	---	---	NA	NA	NA	NA	NA
WASF1	8936	broad.mit.edu	37	6	110423338	110423339	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:110423338_110423339insG	uc003ptv.1	-	10	1811_1812	c.974_975insC	c.(973-975)CCAfs	p.P325fs	WASF1_uc003ptw.1_Frame_Shift_Ins_p.P325fs|WASF1_uc003ptx.1_Frame_Shift_Ins_p.P325fs|WASF1_uc003pty.1_Frame_Shift_Ins_p.P325fs	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	325	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GTGGAGGAGGTGGGGGAGTGGG	0.52			NA											7	754	---	---	---	---	NA	NA	NA	NA	NA
REV3L	5980	broad.mit.edu	37	6	111693903	111693904	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:111693903_111693904insG	uc003puy.3	-	13	5977_5978	c.5654_5655insC	c.(5653-5655)CCAfs	p.P1885fs	REV3L_uc003pux.3_Frame_Shift_Ins_p.P1807fs|REV3L_uc003puz.3_Frame_Shift_Ins_p.P1807fs	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1885	Mediates interaction with MAD2L2.				DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTCCCTACTTGGGGGGGACAT	0.431			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					34	550	---	---	---	---	NA	NA	NA	NA	NA
RFX6	222546	broad.mit.edu	37	6	117250016	117250017	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:117250016_117250017insC	uc003pxm.2	+	18	2556_2557	c.2493_2494insC	c.(2491-2496)CTGCCCfs	p.L831fs		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	831_832					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TTCGTTCACTGCCCCCCTACAG	0.455			NA											7	311	---	---	---	---	NA	NA	NA	NA	NA
UTRN	7402	broad.mit.edu	37	6	144782471	144782471	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:144782471delA	uc003qkt.2	+	21	2938	c.2846delA	c.(2845-2847)GAAfs	p.E949fs	UTRN_uc010khq.1_Frame_Shift_Del_p.E949fs	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	949					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCCCTGCAAGAAAAAAAGGTA	0.348			NA											7	275	---	---	---	---	NA	NA	NA	NA	NA
MTHFD1L	25902	broad.mit.edu	37	6	151358163	151358164	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr6:151358163_151358164insA	uc003qob.2	+	26	3025_3026	c.2757_2758insA	c.(2755-2760)GACAAAfs	p.D919fs	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Frame_Shift_Ins_p.D920fs|MTHFD1L_uc003qoc.2_Frame_Shift_Ins_p.D867fs	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	919_920	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		ACCAACCTGACAAAAAAGGTGT	0.48			NA											9	243	---	---	---	---	NA	NA	NA	NA	NA
FKBP9	11328	broad.mit.edu	37	7	33014803	33014804	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:33014803_33014804insC	uc003tdh.2	+	3	558_559	c.377_378insC	c.(376-378)ATCfs	p.I126fs	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Frame_Shift_Ins_p.I179fs|FKBP9_uc003tdg.2_Frame_Shift_Ins_p.I126fs|FKBP9_uc010kwm.2_Frame_Shift_Ins_p.I33fs	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	126	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			GCTGGTGTGATCCCCCCCAATT	0.446			NA											9	352	---	---	---	---	NA	NA	NA	NA	NA
TXNDC3	51314	broad.mit.edu	37	7	37889877	37889878	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:37889877_37889878insA	uc003tfn.2	+	3	381_382	c.9_10insA	c.(7-12)AGCAAAfs	p.S3fs		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	3_4	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AAATGGCAAGCAAAAAACGAGA	0.317	Ovarian(108;903 1537 27096 29907 47400)		NA							Kartagener_syndrome				7	1218	---	---	---	---	NA	NA	NA	NA	NA
C7orf10	79783	broad.mit.edu	37	7	40899961	40899962	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:40899961_40899962insC	uc003thn.1	+	14	1245_1246	c.1200_1201insC	c.(1198-1203)CCGCCCfs	p.P400fs	C7orf10_uc003thm.1_Frame_Shift_Ins_p.P396fs|C7orf10_uc003tho.1_Frame_Shift_Ins_p.P352fs|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	407_408							transferase activity			ovary(2)	2						AGGCCAGGCCGCCCCCGCTGCT	0.569			NA											8	999	---	---	---	---	NA	NA	NA	NA	NA
FKBP9L	360132	broad.mit.edu	37	7	55759092	55759093	+	Frame_Shift_Ins	INS	-	-	G	rs3110924	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:55759092_55759093insG	uc010kzl.2	-	3	289_290	c.189_190insC	c.(187-192)CCCGACfs	p.P63fs	FKBP9L_uc003tqt.2_5'Flank|FKBP9L_uc011kcs.1_5'Flank	NR_003949				SubName: Full=cDNA, FLJ79189, highly similar to FK506-binding protein 9 (EC 5.2.1.8);												0						ACTGAGCAGTCGGGGGGTTTGT	0.525			NA											11	318	---	---	---	---	NA	NA	NA	NA	NA
FGL2	10875	broad.mit.edu	37	7	76828921	76828922	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:76828921_76828922insG	uc003ugb.2	-	1	229_230	c.189_190insC	c.(187-192)CCCTTGfs	p.P63fs	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	63_64					signal transduction	fibrinogen complex	receptor binding			skin(2)	2						TGAATAGTCAAGGGGGGCAGGC	0.48			NA											7	394	---	---	---	---	NA	NA	NA	NA	NA
GRM3	2913	broad.mit.edu	37	7	86415681	86415682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:86415681_86415682insC	uc003uid.2	+	3	1672_1673	c.573_574insC	c.(571-576)GTGCCCfs	p.V191fs	GRM3_uc010lef.2_Frame_Shift_Ins_p.V189fs|GRM3_uc010leg.2_Frame_Shift_Ins_p.V63fs|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	191_192	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCAGGACCGTGCCCCCCGACTT	0.564	GBM(52;969 1098 3139 52280)		NA											7	337	---	---	---	---	NA	NA	NA	NA	NA
SAMD9L	219285	broad.mit.edu	37	7	92764820	92764820	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:92764820delC	uc003umh.1	-	5	1681	c.465delG	c.(463-465)AAGfs	p.K155fs	SAMD9L_uc003umj.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc003umi.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc010lfb.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc003umk.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc010lfc.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc010lfd.1_Frame_Shift_Del_p.K155fs|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	155										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CAGGTTTTAGCTTACCCTTTT	0.358			NA											413	892	---	---	---	---	NA	NA	NA	NA	NA
TRRAP	8295	broad.mit.edu	37	7	98592294	98592295	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:98592294_98592295insC	uc003upp.2	+	66	10299_10300	c.10090_10091insC	c.(10090-10092)ACCfs	p.T3364fs	TRRAP_uc011kis.1_Frame_Shift_Ins_p.T3335fs|TRRAP_uc003upr.2_Frame_Shift_Ins_p.T3070fs	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3364					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTAAAATCACCCCCCACACT	0.54			NA											7	562	---	---	---	---	NA	NA	NA	NA	NA
ZCWPW1	55063	broad.mit.edu	37	7	100000150	100000151	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:100000150_100000151insT	uc003uut.2	-	16	1707_1708	c.1459_1460insA	c.(1459-1461)ACCfs	p.T487fs	ZCWPW1_uc011kjq.1_Frame_Shift_Ins_p.T367fs|ZCWPW1_uc003uur.2_Intron|ZCWPW1_uc003uus.2_Frame_Shift_Ins_p.T367fs|ZCWPW1_uc011kjr.1_Intron|ZCWPW1_uc011kjp.1_Intron	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	487							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTTGGCTTGGTTTTTTGGGTC	0.48			NA											13	3151	---	---	---	---	NA	NA	NA	NA	NA
IMMP2L	83943	broad.mit.edu	37	7	111127376	111127377	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:111127376_111127377insC	uc003vfq.1	-	3	599_600	c.156_157insG	c.(154-159)GGGAGCfs	p.G52fs	IMMP2L_uc010ljr.1_Frame_Shift_Ins_p.G52fs|IMMP2L_uc003vfr.2_Frame_Shift_Ins_p.G52fs	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	52_53					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		GATGACTGGCTCCCCCCAGGAT	0.416			NA											10	337	---	---	---	---	NA	NA	NA	NA	NA
GRM8	2918	broad.mit.edu	37	7	126173277	126173278	+	Frame_Shift_Ins	INS	-	-	G	rs77499554		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:126173277_126173278insG	uc003vlr.2	-	8	2469_2470	c.2158_2159insC	c.(2158-2160)CACfs	p.H720fs	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Frame_Shift_Ins_p.H720fs|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	720	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AATGATGATGTGGGGGGGATCC	0.505			NA								HNSCC(24;0.065)			7	120	---	---	---	---	NA	NA	NA	NA	NA
TNPO3	23534	broad.mit.edu	37	7	128610258	128610259	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:128610258_128610259insG	uc003vol.1	-	20	2915_2916	c.2541_2542insC	c.(2539-2544)CCCTATfs	p.P847fs	TNPO3_uc010llx.1_Frame_Shift_Ins_p.P258fs|TNPO3_uc003vom.1_Frame_Shift_Ins_p.P781fs|TNPO3_uc010lly.1_Frame_Shift_Ins_p.P881fs|TNPO3_uc010llz.1_Frame_Shift_Ins_p.P783fs	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	847_848					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						GGTAGGGTATAGGGGGGGAGGC	0.485	Pancreas(147;583 2585 39696 52331)		NA											14	538	---	---	---	---	NA	NA	NA	NA	NA
CNOT4	4850	broad.mit.edu	37	7	135047687	135047688	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:135047687_135047688insG	uc011kpy.1	-	11	2183_2184	c.2091_2092insC	c.(2089-2094)CCCAGCfs	p.P697fs	CNOT4_uc003vss.2_Frame_Shift_Ins_p.P623fs|CNOT4_uc011kpz.1_Frame_Shift_Ins_p.P694fs|CNOT4_uc003vst.2_Frame_Shift_Ins_p.P626fs	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GGGGTTTTGCTGGGGGGTCTGA	0.53	Ovarian(51;766 1130 5502 35047 50875)		NA											10	479	---	---	---	---	NA	NA	NA	NA	NA
CNOT4	4850	broad.mit.edu	37	7	135106950	135106951	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:135106950_135106951insT	uc003vsv.1	-	3	633_634	c.326_327insA	c.(325-327)AACfs	p.N109fs	CNOT4_uc003vss.2_Frame_Shift_Ins_p.N109fs|CNOT4_uc011kpz.1_Frame_Shift_Ins_p.N109fs|CNOT4_uc003vst.2_Frame_Shift_Ins_p.N109fs|CNOT4_uc003vsu.1_Frame_Shift_Ins_p.N109fs|CNOT4_uc011kpy.1_Frame_Shift_Ins_p.N109fs	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	109	RRM.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						CAAAGACGAGGTTTTTTTGTAC	0.356	Ovarian(51;766 1130 5502 35047 50875)		NA											7	409	---	---	---	---	NA	NA	NA	NA	NA
TRPV5	56302	broad.mit.edu	37	7	142612493	142612494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:142612493_142612494insC	uc003wby.1	-	10	1533_1534	c.1269_1270insG	c.(1267-1272)GGGCCAfs	p.G423fs		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	423_424	Helical; (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					ACATGGAATGGCCCCCCAAGAA	0.505			NA											12	670	---	---	---	---	NA	NA	NA	NA	NA
KEL	3792	broad.mit.edu	37	7	142639979	142639980	+	Frame_Shift_Ins	INS	-	-	C	rs140258059		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:142639979_142639980insC	uc003wcb.2	-	17	2133_2134	c.1923_1924insG	c.(1921-1926)GGGCTAfs	p.G641fs		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	641_642	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GCGATGGCTAGCCCCCCAACGT	0.5			NA											21	1089	---	---	---	---	NA	NA	NA	NA	NA
OR2F2	135948	broad.mit.edu	37	7	143633070	143633070	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr7:143633070delG	uc011ktv.1	+	1	745	c.745delG	c.(745-747)GCCfs	p.A249fs		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CACGGTGGTTGCCCTGTGCTA	0.502			NA											32	455	---	---	---	---	NA	NA	NA	NA	NA
CSMD1	64478	broad.mit.edu	37	8	3216722	3216722	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:3216722delG	uc011kwk.1	-	21	3649	c.3259delC	c.(3259-3261)CTGfs	p.L1087fs	CSMD1_uc011kwj.1_Frame_Shift_Del_p.L479fs|CSMD1_uc003wqe.2_Frame_Shift_Del_p.L243fs	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1087	Sushi 6.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCCCACCCAGGCAGGTAAGC	0.552			NA											27	250	---	---	---	---	NA	NA	NA	NA	NA
PSD3	23362	broad.mit.edu	37	8	18413784	18413785	+	Frame_Shift_Ins	INS	-	-	G	rs28651847	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:18413784_18413785insG	uc003wza.2	-	15	2965_2966	c.2862_2863insC	c.(2860-2865)CCCGACfs	p.P954fs	PSD3_uc003wyx.3_Frame_Shift_Ins_p.P283fs|PSD3_uc003wyy.2_Frame_Shift_Ins_p.P420fs|PSD3_uc003wyz.2_Frame_Shift_Ins_p.P255fs	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	955_956					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACCTTCTTGTCGGGGGGATATG	0.48			NA											7	790	---	---	---	---	NA	NA	NA	NA	NA
NRG1	3084	broad.mit.edu	37	8	32614020	32614021	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:32614020_32614021insC	uc003xiv.2	+	9	1420_1421	c.903_904insC	c.(901-906)CCACCCfs	p.P301fs	NRG1_uc011lbf.1_Frame_Shift_Ins_p.P298fs|NRG1_uc010lvo.2_Frame_Shift_Ins_p.P298fs|NRG1_uc003xiu.2_Frame_Shift_Ins_p.P306fs|NRG1_uc003xiw.2_Frame_Shift_Ins_p.P298fs|NRG1_uc003xit.2_Frame_Shift_Ins_p.P301fs|NRG1_uc010lvr.2_Frame_Shift_Ins_p.P43fs|NRG1_uc010lvs.2_Frame_Shift_Ins_p.P43fs|NRG1_uc010lvp.2_Frame_Shift_Ins_p.P255fs|NRG1_uc010lvq.2_Frame_Shift_Ins_p.P238fs|NRG1_uc011lbg.1_Frame_Shift_Ins_p.P147fs|NRG1_uc011lbh.1_Frame_Shift_Ins_p.P144fs|NRG1_uc003xja.2_Frame_Shift_Ins_p.P112fs	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	301_302	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATCCTAACCCACCCCCCGAGAA	0.495			NA											10	254	---	---	---	---	NA	NA	NA	NA	NA
UNC5D	137970	broad.mit.edu	37	8	35584019	35584020	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:35584019_35584020insG	uc003xjr.1	+	10	1981_1982	c.1653_1654insG	c.(1651-1656)TTAGGGfs	p.L551fs	UNC5D_uc003xjs.1_Frame_Shift_Ins_p.L546fs|UNC5D_uc003xju.1_Frame_Shift_Ins_p.L127fs|UNC5D_uc003xjt.1_Frame_Shift_Ins_p.L309fs	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	551_552	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGGCCATTTAGGGGGGCGCTT	0.411			NA											9	533	---	---	---	---	NA	NA	NA	NA	NA
SGK196	84197	broad.mit.edu	37	8	42958728	42958729	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:42958728_42958729insC	uc003xpw.2	+	4	296_297	c.37_38insC	c.(37-39)GCCfs	p.A13fs		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	13						integral to membrane	ATP binding|protein kinase activity				0						GAGAGGCCTCGCCCCCCGAGAG	0.54			NA											8	194	---	---	---	---	NA	NA	NA	NA	NA
ARFGEF1	10565	broad.mit.edu	37	8	68128855	68128856	+	Frame_Shift_Ins	INS	-	-	G	rs142098461		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:68128855_68128856insG	uc003xxo.1	-	33	5045_5046	c.4655_4656insC	c.(4654-4656)CCAfs	p.P1552fs	ARFGEF1_uc003xxl.1_Frame_Shift_Ins_p.P1006fs|ARFGEF1_uc003xxn.1_Frame_Shift_Ins_p.P535fs	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1552					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAGATGGAGGTGGGGGGGCAGT	0.421			NA											20	392	---	---	---	---	NA	NA	NA	NA	NA
SULF1	23213	broad.mit.edu	37	8	70488248	70488249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:70488248_70488249insG	uc010lza.1	+	6	933_934	c.216_217insG	c.(214-219)CATGGGfs	p.H72fs	SULF1_uc003xyd.2_Frame_Shift_Ins_p.H72fs|SULF1_uc003xye.2_Frame_Shift_Ins_p.H72fs|SULF1_uc003xyf.2_Frame_Shift_Ins_p.H72fs|SULF1_uc003xyg.2_Frame_Shift_Ins_p.H72fs	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	72_73					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTATGGAACATGGGGGGGCCAC	0.495			NA											7	130	---	---	---	---	NA	NA	NA	NA	NA
SULF1	23213	broad.mit.edu	37	8	70514026	70514026	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:70514026delT	uc010lza.1	+	10	1740	c.1023delT	c.(1021-1023)CCTfs	p.P341fs	SULF1_uc003xyd.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xye.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyf.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyg.2_Frame_Shift_Del_p.P341fs|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	341					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTCGTGTGCCTTTTTTTATTC	0.408			NA											7	2419	---	---	---	---	NA	NA	NA	NA	NA
LY96	23643	broad.mit.edu	37	8	74903692	74903693	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:74903692_74903693insT	uc003yad.2	+	1	106_107	c.15_16insT	c.(13-18)CTGTTTfs	p.L5fs		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	5_6					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			TACCATTTCTGTTTTTTTCCAC	0.366	GBM(131;1357 1748 34893 50149 52212)		NA											8	870	---	---	---	---	NA	NA	NA	NA	NA
SLC26A7	115111	broad.mit.edu	37	8	92261931	92261932	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:92261931_92261932insC	uc003yex.2	+	3	330_331	c.52_53insC	c.(52-54)ACCfs	p.T18fs	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Frame_Shift_Ins_p.T18fs|SLC26A7_uc003yfa.2_Frame_Shift_Ins_p.T18fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	18	Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CAAGATGCATACCCCCCAGTGT	0.396			NA											9	457	---	---	---	---	NA	NA	NA	NA	NA
VPS13B	157680	broad.mit.edu	37	8	100779108	100779121	+	Frame_Shift_Del	DEL	TCAATCTCGTGAAT	TCAATCTCGTGAAT	-	rs145846582		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	TCAATCTCGTGAAT	TCAATCTCGTGAAT	-	-	TCAATCTCGTGAAT	TCAATCTCGTGAAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:100779108_100779121delTCAATCTCGTGAAT	uc003yiv.2	+	40	7343_7356	c.7232_7245delTCAATCTCGTGAAT	c.(7231-7245)ATCAATCTCGTGAATfs	p.I2411fs	VPS13B_uc003yiw.2_Frame_Shift_Del_p.I2386fs	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2411_2415					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGCCGGATATCAATCTCGTGAATGACCAGAAGA	0.374	Colon(161;2205 2542 7338 31318)		NA											16	179	---	---	---	---	NA	NA	NA	NA	NA
FBXO43	286151	broad.mit.edu	37	8	101153252	101153255	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	TCTT	TCTT	-	-	TCTT	TCTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr8:101153252_101153255delTCTT	uc003yjd.2	-	2	1940_1943	c.1227_1230delAAGA	c.(1225-1230)AAAAGAfs	p.K409fs	FBXO43_uc003yje.2_Frame_Shift_Del_p.K375fs|FBXO43_uc010mbp.1_Frame_Shift_Del_p.K409fs	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	409_410					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CAGCTGCTGCTCTTTTTTCAGAGT	0.49			NA											8	152	---	---	---	---	NA	NA	NA	NA	NA
RLN2	6019	broad.mit.edu	37	9	5304560	5304561	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:5304560_5304561insA	uc003zja.1	-	1	20_21	c.20_21insT	c.(19-21)TTCfs	p.F7fs	RLN2_uc003ziz.1_Frame_Shift_Ins_p.F7fs	NM_134441	NP_604390	P04090	REL2_HUMAN	relaxin 2 isoform 1 preproprotein	7					female pregnancy	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTAGCAGGTGGAAAAAAAACAG	0.535			NA											11	403	---	---	---	---	NA	NA	NA	NA	NA
FREM1	158326	broad.mit.edu	37	9	14823286	14823287	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:14823286_14823287insG	uc003zlm.2	-	13	2798_2799	c.2208_2209insC	c.(2206-2211)CCCATGfs	p.P736fs	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	736_737	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGTCTTGCATGGGGGGCATGT	0.441			NA											7	791	---	---	---	---	NA	NA	NA	NA	NA
UBAP2	55833	broad.mit.edu	37	9	33923478	33923479	+	Splice_Site	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:33923478_33923479insG	uc003ztq.1	-	25	2910	c.2797_splice	c.e25-1	p.V933_splice	UBAP2_uc011loc.1_Splice_Site_p.V842_splice|UBAP2_uc011lod.1_Splice_Site_p.V666_splice|UBAP2_uc011loe.1_Splice_Site_p.V688_splice|UBAP2_uc011lof.1_Intron|UBAP2_uc003ztn.1_Splice_Site_p.V172_splice|UBAP2_uc003zto.1_Splice_Site_p.V172_splice|UBAP2_uc003ztp.1_Splice_Site_p.V172_splice	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2											ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGGAGGGACCTGGGGGGGCAAG	0.594			NA											14	338	---	---	---	---	NA	NA	NA	NA	NA
TRPM6	140803	broad.mit.edu	37	9	77377691	77377692	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:77377691_77377692insC	uc004ajl.1	-	26	4133_4134	c.3895_3896insG	c.(3895-3897)GCAfs	p.A1299fs	TRPM6_uc004ajk.1_Frame_Shift_Ins_p.A1294fs|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Frame_Shift_Ins_p.A255fs	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1299	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTCAAGAAGTGCCCCCCTCTGC	0.48			NA											9	460	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	9	90748545	90748546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:90748545_90748546insC	uc011lti.1	-	2	257_258	c.228_229insG	c.(226-231)GGGAGGfs	p.G76fs						SubName: Full=cDNA FLJ59639;												NA						CCTCTGGGCCTCCCCCTCCGCC	0.599			NA											7	393	---	---	---	---	NA	NA	NA	NA	NA
SECISBP2	79048	broad.mit.edu	37	9	91943617	91943618	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:91943617_91943618insA	uc004aqj.1	+	5	697_698	c.617_618insA	c.(616-618)GCAfs	p.A206fs	SECISBP2_uc010mqn.1_Frame_Shift_Ins_p.A206fs|SECISBP2_uc004aqi.1_Frame_Shift_Ins_p.A133fs|SECISBP2_uc011ltk.1_Frame_Shift_Ins_p.A205fs|SECISBP2_uc004aqk.1_Frame_Shift_Ins_p.A133fs|SECISBP2_uc010mqo.1_5'UTR|SECISBP2_uc011ltl.1_Frame_Shift_Ins_p.A138fs	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	206					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						AGAATCATTGCAAAAAATGTAT	0.356			NA											7	202	---	---	---	---	NA	NA	NA	NA	NA
ROR2	4920	broad.mit.edu	37	9	94486955	94486955	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:94486955delG	uc004arj.1	-	9	2020	c.1821delC	c.(1819-1821)TCCfs	p.S607fs	ROR2_uc004ari.1_Frame_Shift_Del_p.S467fs	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	607	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CGTGGTGGCTGGATAGGTACT	0.607			NA											48	155	---	---	---	---	NA	NA	NA	NA	NA
MRPL50	54534	broad.mit.edu	37	9	104152774	104152775	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:104152774_104152775insG	uc004bbe.2	-	2	495_496	c.450_451insC	c.(448-453)CCCAATfs	p.P150fs	MRPL50_uc011lvj.1_Intron	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	150_151						mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				ATTTTCAAATTGGGGGGCAGAT	0.401			NA											18	542	---	---	---	---	NA	NA	NA	NA	NA
OR13C4	138804	broad.mit.edu	37	9	107289148	107289148	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:107289148delG	uc011lvn.1	-	1	343	c.343delC	c.(343-345)CTTfs	p.L115fs		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATCATGCCAAGGAGGAAACAT	0.438			NA											95	757	---	---	---	---	NA	NA	NA	NA	NA
C9orf152	401546	broad.mit.edu	37	9	112963553	112963554	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:112963553_112963554insG	uc011lwk.1	-	2	948_949	c.394_395insC	c.(394-396)CAGfs	p.Q132fs		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	132											0						ACTGGTGTCCTGGGGGGAGGTT	0.564			NA											7	861	---	---	---	---	NA	NA	NA	NA	NA
COL5A1	1289	broad.mit.edu	37	9	137623482	137623482	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chr9:137623482delG	uc004cfe.2	+	8	1687	c.1305delG	c.(1303-1305)CCGfs	p.P435fs		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	435	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGGGAATGCCGGCGAACCAGG	0.567			NA											15	101	---	---	---	---	NA	NA	NA	NA	NA
CLCN4	1183	broad.mit.edu	37	X	10188762	10188763	+	Frame_Shift_Ins	INS	-	-	C	rs142375213		TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:10188762_10188763insC	uc004csy.3	+	12	2467_2468	c.2037_2038insC	c.(2035-2040)GAACCCfs	p.E679fs	CLCN4_uc011mid.1_Frame_Shift_Ins_p.E585fs	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	679_680	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TCACGGAGGAACCCCCCGAGCT	0.564	Melanoma(74;1050 1296 1576 30544 38374)		NA											7	228	---	---	---	---	NA	NA	NA	NA	NA
USP9X	8239	broad.mit.edu	37	X	40982956	40982957	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:40982956_40982957insC	uc004dfb.2	+	2	708_709	c.75_76insC	c.(73-78)CAGCCCfs	p.Q25fs	USP9X_uc004dfc.2_Frame_Shift_Ins_p.Q25fs	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	25_26					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GACAGTCTCAGCCCCCCCTCCA	0.426	Ovarian(172;1807 2695 35459 49286)		NA											7	120	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	X	48159107	48159108	+	Frame_Shift_Ins	INS	-	-	G	rs41305745	by1000genomes	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:48159107_48159108insG	uc010nib.1	-	6	512_513	c.425_426insC	c.(424-426)CCGfs	p.P142fs		NM_174962	NP_777622			synovial sarcoma, X breakpoint 9												NA						TTGGTTTTCCCGGGGGGCACAG	0.49			NA											20	409	---	---	---	---	NA	NA	NA	NA	NA
SSX3	10214	broad.mit.edu	37	X	48207024	48207025	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:48207024_48207025insC	uc004djd.1	-	7	575_576	c.481_482insG	c.(481-483)GAAfs	p.E161fs		NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						CCAGGCATGTTCCCCCCTTTTG	0.48	Colon(37;227 826 19399 40970 48007)		NA											10	822	---	---	---	---	NA	NA	NA	NA	NA
SSX3	10214	broad.mit.edu	37	X	48209462	48209463	+	Frame_Shift_Ins	INS	-	-	G	rs6651589	byFrequency	TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:48209462_48209463insG	uc004djd.1	-	6	519_520	c.425_426insC	c.(424-426)CCGfs	p.P142fs	SSX3_uc004dje.2_Frame_Shift_Ins_p.P142fs	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TTGGTTTTCCCGGGGGGCACAG	0.495	Colon(37;227 826 19399 40970 48007)		NA											8	424	---	---	---	---	NA	NA	NA	NA	NA
TFE3	7030	broad.mit.edu	37	X	48887951	48887952	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:48887951_48887952insC	uc004dmb.3	-	10	1683_1684	c.1445_1446insG	c.(1444-1446)GGAfs	p.G482fs	TFE3_uc004dmc.3_Frame_Shift_Ins_p.G377fs	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	482					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						TCTGGGCAGGTCCCCCCCCTAC	0.649			NA	T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								20	153	---	---	---	---	NA	NA	NA	NA	NA
COL4A5	1287	broad.mit.edu	37	X	107834821	107834822	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:107834821_107834822insC	uc004enz.1	+	21	1572_1573	c.1370_1371insC	c.(1369-1371)GGCfs	p.G457fs	COL4A5_uc011mso.1_Frame_Shift_Ins_p.G457fs|COL4A5_uc004eob.1_Frame_Shift_Ins_p.G65fs	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	457	Triple-helical region.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GGCCCTCCAGGCCCCCCAGGAT	0.406			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				7	795	---	---	---	---	NA	NA	NA	NA	NA
CAPN6	827	broad.mit.edu	37	X	110494259	110494259	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:110494259delA	uc004epc.1	-	8	1212	c.1044delT	c.(1042-1044)TTTfs	p.F348fs	CAPN6_uc011msu.1_Frame_Shift_Del_p.F93fs	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	348	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						CCTTTCGGCCAAAAATAGGGT	0.488			NA											7	1524	---	---	---	---	NA	NA	NA	NA	NA
ZCCHC16	340595	broad.mit.edu	37	X	111698756	111698756	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:111698756delC	uc004epo.1	+	3	1241	c.800delC	c.(799-801)ACCfs	p.T267fs		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	267							nucleic acid binding|zinc ion binding			ovary(1)	1						CTGCCTCTCACCCCAGCCAAA	0.547			NA											76	177	---	---	---	---	NA	NA	NA	NA	NA
GPR112	139378	broad.mit.edu	37	X	135455155	135455156	+	Frame_Shift_Ins	INS	-	-	G			TCGA-44-2656-01A-02W-0928-08	TCGA-44-2656-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b2773f71-23ca-4f92-99cb-1452846a1b36	03b8420d-480f-48e1-88a7-8ee9917049a6	g.chrX:135455155_135455156insG	uc004ezu.1	+	15	7999_8000	c.7708_7709insG	c.(7708-7710)CGGfs	p.R2570fs	GPR112_uc010nsb.1_Frame_Shift_Ins_p.R2365fs	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2570	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GGCTGTGCTGCGGGGGGACCAC	0.53			NA											13	1600	---	---	---	---	NA	NA	NA	NA	NA
