Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CTRC	11330	broad.mit.edu	37	1	15772225	15772225	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:15772225A>G	uc001awi.1	+	7	796	c.773A>G	c.(772-774)TAC>TGC	p.Y258C	CTRC_uc001awj.1_Silent_p.L209L	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	258	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGTCCGCCTACATCGACTGG	0.537			NA											18	49					0	0	0.012319	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474875	20474875	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:20474875C>A	uc009vpp.1	+	5	715	c.617C>A	c.(616-618)GCG>GAG	p.A206E		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	163					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CAATCCCCAGCGCCCCCCGCC	0.647			NA											14	19					7.93312e-07	9.33987e-07	0.00245	1	0
LDLRAD2	401944	broad.mit.edu	37	1	22141121	22141121	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:22141121C>G	uc001bfg.1	+	2	503	c.316C>G	c.(316-318)CCG>GCG	p.P106A		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	106	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		CCCGGCCGACCCGTGCGCCCC	0.622			NA											6	10					0	0	0.001168	0	0
C1orf94	84970	broad.mit.edu	37	1	34666517	34666517	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:34666517A>T	uc001bxs.3	+	3	983	c.584A>T	c.(583-585)AAA>ATA	p.K195I	C1orf94_uc001bxt.2_Missense_Mutation_p.K385I	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	195							protein binding				0		Myeloproliferative disorder(586;0.0393)				CCGCCCAAGAAACCTACATGT	0.582			NA											8	26					0	0	0.004482	0	0
ZMYM4	9202	broad.mit.edu	37	1	35863113	35863113	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:35863113G>T	uc001byt.2	+	20	3246	c.3166G>T	c.(3166-3168)GAA>TAA	p.E1056*	ZMYM4_uc009vuu.2_Nonsense_Mutation_p.E1024*|ZMYM4_uc001byu.2_Nonsense_Mutation_p.E732*|ZMYM4_uc009vuv.2_Nonsense_Mutation_p.E795*	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1056					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AATGATTGCAGAAGATGAAGA	0.363			NA											15	15					1.05317e-09	1.33292e-09	0.00245	1	0
PLK3	1263	broad.mit.edu	37	1	45268721	45268721	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:45268721A>T	uc001cmn.2	+	7	944	c.844A>T	c.(844-846)AGC>TGC	p.S282C	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	282	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					GCTGCCTGCCAGCCTCTCACT	0.622			NA											16	90					0	0	0.004007	0	0
NRD1	4898	broad.mit.edu	37	1	52303236	52303236	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:52303236C>A	uc001ctc.3	-	3	1009	c.687G>T	c.(685-687)AAG>AAT	p.K229N	NRD1_uc009vzb.2_Intron|NRD1_uc001ctd.3_Intron|NRD1_uc001cte.2_Missense_Mutation_p.K97N|NRD1_uc001ctf.2_Intron|NRD1_uc010ong.1_Intron|NRD1_uc009vzc.1_Intron|MIR761_hsa-mir-761|MI0003941_5'Flank|NRD1_uc001ctg.1_RNA	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AATAAGTTGACTTAAACCACA	0.373			NA											29	78					3.73148e-12	5.22923e-12	0.007291	1	0
NEGR1	257194	broad.mit.edu	37	1	72076749	72076749	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:72076749C>A	uc001dfw.2	-	5	848	c.748G>T	c.(748-750)GTG>TTG	p.V250L	NEGR1_uc001dfv.2_Missense_Mutation_p.V122L|NEGR1_uc010oqs.1_Missense_Mutation_p.V206L	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	250	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GGAGGCGGCACACCTGCACCT	0.458			NA											14	69					1.49906e-05	1.69114e-05	0.00245	1	0
FPGT	8790	broad.mit.edu	37	1	74670891	74670891	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:74670891G>T	uc001dgb.1	+	4	1197	c.1160G>T	c.(1159-1161)AGT>ATT	p.S387I	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Splice_Site_p.C12_splice|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	387					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						ATAACTTTTAGTATCTTTCCA	0.383			NA											10	28					3.86212e-05	4.26201e-05	0.008291	1	0
ASB17	127247	broad.mit.edu	37	1	76397599	76397599	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:76397599A>T	uc001dhe.1	-	1	518	c.378T>A	c.(376-378)AGT>AGA	p.S126R	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	126					intracellular signal transduction					ovary(1)	1						CCAGGTTACAACTTCTGTCTT	0.338			NA											14	23					0	0	0.00245	0	0
PRKACB	5567	broad.mit.edu	37	1	84700881	84700881	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:84700881C>A	uc001djj.2	+	10	1213	c.949C>A	c.(949-951)CCA>ACA	p.P317T	PRKACB_uc001djl.2_Missense_Mutation_p.P364T|PRKACB_uc010ort.1_Missense_Mutation_p.P324T|PRKACB_uc001djn.2_Missense_Mutation_p.P321T|PRKACB_uc010oru.1_Missense_Mutation_p.P305T|PRKACB_uc001djp.2_Missense_Mutation_p.P323T|PRKACB_uc001djq.2_Missense_Mutation_p.P287T|PRKACB_uc010orv.1_Missense_Mutation_p.P304T	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	317	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TCCATTCATACCAAAGTTTAG	0.343			NA											31	56					2.1956e-27	3.93459e-27	0.004289	1	0
NTNG1	22854	broad.mit.edu	37	1	107867366	107867366	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:107867366C>A	uc001dvh.3	+	3	1427	c.709C>A	c.(709-711)CTA>ATA	p.L237I	NTNG1_uc001dvf.3_Missense_Mutation_p.L237I|NTNG1_uc010out.1_Missense_Mutation_p.L237I|NTNG1_uc001dvc.3_Missense_Mutation_p.L237I|NTNG1_uc001dvd.1_Missense_Mutation_p.L237I	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	237	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		TGGACCTCGCCTACGCAATAT	0.428			NA											15	32					0.000219431	0.000235729	0.00245	1	0
TBX15	6913	broad.mit.edu	37	1	119427378	119427378	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:119427378G>A	uc001ehl.1	-	8	1783	c.1468C>T	c.(1468-1470)CAG>TAG	p.Q490*	TBX15_uc009whj.1_Nonsense_Mutation_p.Q314*	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	596						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		ACGGACATCTGGGAGGAGGAG	0.552			NA											22	63					0	0	0.012319	0	0
SEMA6C	10500	broad.mit.edu	37	1	151108068	151108068	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:151108068G>A	uc001ewu.2	-	14	1732	c.1432C>T	c.(1432-1434)CGG>TGG	p.R478W	SEMA6C_uc001ewv.2_Missense_Mutation_p.R478W|SEMA6C_uc001eww.2_Missense_Mutation_p.R438W|SEMA6C_uc010pcq.1_Missense_Mutation_p.R478W	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	478	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGCCTCACCGGGCAGGGCTG	0.597			NA											16	206					0	0	0.00499	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058462	152058462	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:152058462C>A	uc001ezo.1	-	3	1761	c.1696G>T	c.(1696-1698)GAA>TAA	p.E566*		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	566							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ACAGGCAGTTCACCTGTCTCT	0.542			NA											54	182					4.6707e-30	8.55943e-30	0.01441	1	0
CD5L	922	broad.mit.edu	37	1	157805682	157805682	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:157805682C>A	uc001frk.3	-	3	462	c.319G>T	c.(319-321)GAG>TAG	p.E107*		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	107	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCTTCTTGCTCACACTGAGCC	0.483			NA											61	368					1.19403e-26	2.12098e-26	0.01441	1	0
SPTA1	6708	broad.mit.edu	37	1	158612763	158612763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:158612763C>T	uc001fst.1	-	32	4645	c.4446G>A	c.(4444-4446)TGG>TGA	p.W1482*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1482	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGAGAGCCTTCCACCTAGAGG	0.483			NA											31	38					0	0	0.010818	0	0
SPTA1	6708	broad.mit.edu	37	1	158648304	158648304	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:158648304G>T	uc001fst.1	-	6	898	c.699C>A	c.(697-699)CCC>CCA	p.P233P		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	233	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTGAATTAAGGGTAGGTCAG	0.398			NA											17	62					3.41278e-10	4.4159e-10	0.00499	1	0
ATP1A4	480	broad.mit.edu	37	1	160144384	160144384	+	Missense_Mutation	SNP	G	G	T	rs150078418		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:160144384G>T	uc001fve.3	+	15	2637	c.2158G>T	c.(2158-2160)GTG>TTG	p.V720L	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.V223L|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	720	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.V720M(1)		ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGTTGTGGCCGTGACAGGTGA	0.542			NA											29	35					8.16721e-17	1.2435e-16	0.010818	1	0
FCGR3B	2215	broad.mit.edu	37	1	161594354	161594354	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:161594354A>G	uc009wul.2	-	5	927	c.653T>C	c.(652-654)CTT>CCT	p.L218P		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	218					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CACTGCAAAAAGGAGTACCAT	0.433			NA											31	133					0	0	0.010818	0	0
FASLG	356	broad.mit.edu	37	1	172635120	172635120	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:172635120G>A	uc001gis.2	+	4	967	c.810G>A	c.(808-810)GAG>GAA	p.E270E	FASLG_uc001git.2_3'UTR	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	270	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						TCAATTTTGAGGAATCTCAGA	0.433	Ovarian(28;486 876 30334 44033)		NA											41	45					0	0	0.009718	0	0
SLC9A11	284525	broad.mit.edu	37	1	173505044	173505044	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:173505044C>T	uc001giz.2	-	15	2123	c.1700G>A	c.(1699-1701)AGT>AAT	p.S567N	SLC9A11_uc009wwe.2_Missense_Mutation_p.S125N|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	567					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TATAAGCCAACTTCTAGTTCT	0.264			NA											4	36					0	0	0.009096	0	0
TNN	63923	broad.mit.edu	37	1	175086339	175086339	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:175086339C>A	uc001gkl.1	+	10	2497	c.2384C>A	c.(2383-2385)ACA>AAA	p.T795K		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	795	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AAGGCCCAGACAGGTAAGGAG	0.527			NA											25	74					4.7796e-09	5.93785e-09	0.004656	1	0
FAM129A	116496	broad.mit.edu	37	1	184764303	184764303	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:184764303C>A	uc001gra.2	-	14	2789	c.2595G>T	c.(2593-2595)ATG>ATT	p.M865I	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	865					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TTTGCCCTCCCATCTCTTCTT	0.582			NA											59	67					4.45325e-31	8.23547e-31	0.01441	1	0
FAM5C	339479	broad.mit.edu	37	1	190203595	190203595	+	Silent	SNP	G	G	T	rs145486539		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:190203595G>T	uc001gse.1	-	5	863	c.631C>A	c.(631-633)CGG>AGG	p.R211R	FAM5C_uc010pot.1_Silent_p.R109R	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	211						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GGACCAGTCCGTGTTTCTGTT	0.378			NA											24	38					4.72057e-08	5.74124e-08	0.003954	1	0
MYOG	4656	broad.mit.edu	37	1	203054889	203054889	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:203054889C>T	uc001gzd.2	-	1	489	c.201G>A	c.(199-201)CCG>CCA	p.P67P		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	67					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						TACACGCCCACGGCAGGCACT	0.682			NA											9	112					0	0	0.008291	0	0
BTG2	7832	broad.mit.edu	37	1	203276294	203276294	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:203276294C>G	uc001gzq.2	+	2	276	c.205C>G	c.(205-207)CGC>GGC	p.R69G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	69					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CCGCTGCATTCGCATCAACCA	0.612			NA											13	35					0	0	0.013537	0	0
USH2A	7399	broad.mit.edu	37	1	215844561	215844561	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:215844561T>G	uc001hku.1	-	64	14273	c.13886A>C	c.(13885-13887)GAG>GCG	p.E4629A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4629	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGTGCAATCTCAGGGGTCTG	0.493			NA								HNSCC(13;0.011)			15	112					0	0	0.003163	0	0
USH2A	7399	broad.mit.edu	37	1	216373371	216373371	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:216373371C>A	uc001hku.1	-	17	3796	c.3409G>T	c.(3409-3411)GTA>TTA	p.V1137L	USH2A_uc001hkv.2_Missense_Mutation_p.V1137L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1137	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGACAGCTACACTCCTTGTT	0.408			NA								HNSCC(13;0.011)			26	100					1.42536e-11	1.95684e-11	0.004656	1	0
HHIPL2	79802	broad.mit.edu	37	1	222696185	222696185	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:222696185T>A	uc001hnh.1	-	9	1991	c.1933A>T	c.(1933-1935)AGA>TGA	p.R645*		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	645					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GAAGATTTTCTAGCAGCTTTC	0.428			NA											40	183					0	0	0.00623	0	0
HHIPL2	79802	broad.mit.edu	37	1	222712016	222712016	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:222712016C>A	uc001hnh.1	-	5	1609	c.1551G>T	c.(1549-1551)CTG>CTT	p.L517L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	517					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CAAAGATATACAGGCCATTGA	0.368			NA											8	58					2.17888e-05	2.44445e-05	0.006214	1	0
ABCB10	23456	broad.mit.edu	37	1	229675222	229675222	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:229675222C>A	uc001htp.3	-	6	1363	c.1320G>T	c.(1318-1320)TGG>TGT	p.W440C		NM_012089	NP_036221	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B, member 10	440	Mitochondrial intermembrane (Potential).|ABC transmembrane type-1.|Helical; (Potential).					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(2)	2	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				TTATTCCAACCCAGAAAGCAT	0.423			NA											55	71					4.17463e-26	7.35098e-26	0.01441	1	0
GNPAT	8443	broad.mit.edu	37	1	231410987	231410987	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:231410987G>C	uc001hup.3	+	13	1970	c.1764G>C	c.(1762-1764)TTG>TTC	p.L588F	GNPAT_uc009xfp.2_Missense_Mutation_p.L527F	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	588					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				AGTACCTTTTGAGTGAAGAAG	0.408			NA											5	54					0	0	0.000602	0	0
PCNXL2	80003	broad.mit.edu	37	1	233122108	233122108	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:233122108C>T	uc001hvl.2	-	33	6205	c.5970G>A	c.(5968-5970)TCG>TCA	p.S1990S	PCNXL2_uc001hvk.1_Silent_p.S642S|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1990	Ser-rich.					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GGGACGTGGCCGAGGCGTGCA	0.687			NA											13	9					0	0	0.001855	0	0
RYR2	6262	broad.mit.edu	37	1	237865347	237865347	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:237865347T>A	uc001hyl.1	+	66	9557	c.9437T>A	c.(9436-9438)ATT>AAT	p.I3146N	RYR2_uc010pxz.1_Missense_Mutation_p.I101N	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3146					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCAAGAGTATTTACGTGGAG	0.323			NA											10	19					0	0	0.006214	0	0
FMN2	56776	broad.mit.edu	37	1	240371044	240371044	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:240371044C>A	uc010pyd.1	+	5	3157	c.2932C>A	c.(2932-2934)CCA>ACA	p.P978T	FMN2_uc010pye.1_Missense_Mutation_p.P982T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	978	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AATACCTCCTCCACCCCCTCT	0.716			NA											5	21					3.86212e-05	4.26201e-05	0.008291	1	0
RGS7	6000	broad.mit.edu	37	1	241094038	241094038	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:241094038C>A	uc001hyv.2	-	6	694	c.364G>T	c.(364-366)GAG>TAG	p.E122*	RGS7_uc010pyh.1_Nonsense_Mutation_p.E96*|RGS7_uc010pyj.1_Nonsense_Mutation_p.E38*|RGS7_uc001hyu.2_Nonsense_Mutation_p.E122*|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Nonsense_Mutation_p.E122*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	122					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTTTCCGGCTCCCAACAATTT	0.388			NA											39	193					6.68952e-21	1.11035e-20	0.013114	1	0
AHCTF1	25909	broad.mit.edu	37	1	247025359	247025359	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:247025359C>G	uc001ibu.1	-	27	3644	c.3637G>C	c.(3637-3639)GCA>CCA	p.A1213P	AHCTF1_uc001ibv.1_Missense_Mutation_p.A1222P|AHCTF1_uc009xgs.1_Missense_Mutation_p.A74P|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1213	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GAGGGAGATGCTAAAGGTGTT	0.433	Colon(145;197 1800 4745 15099 26333)		NA											44	58					0	0	0.00874	0	0
VN1R5	317705	broad.mit.edu	37	1	247420349	247420349	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:247420349C>A	uc010pyu.1	+	2	976	c.976C>A	c.(976-978)CAA>AAA	p.Q326K		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	326	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			TGCTGATAACCAAATATTCAA	0.239	GBM(98;63 1399 4825 21305 33017)		NA											23	98					2.89027e-11	3.90186e-11	0.014323	1	0
OR2G3	81469	broad.mit.edu	37	1	247769612	247769612	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:247769612C>A	uc010pyz.1	+	1	725	c.725C>A	c.(724-726)TCC>TAC	p.S242Y		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGCACCTGCTCCTCCCACCTT	0.483			NA											15	47					1.52009e-12	2.13763e-12	0.003163	1	0
OR1C1	26188	broad.mit.edu	37	1	247921471	247921471	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:247921471G>T	uc010pza.1	-	1	238	c.238C>A	c.(238-240)CAA>AAA	p.Q80K		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			ACTACCATTTGGGGGACTGTA	0.463			NA											12	43					9.31168e-06	1.06532e-05	0.001855	1	0
TRIM58	25893	broad.mit.edu	37	1	248039358	248039358	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248039358C>T	uc001ido.2	+	6	1076	c.1028C>T	c.(1027-1029)TCA>TTA	p.S343L	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	343	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCTTCTCATCAGGGAGGCAT	0.562			NA											8	80					0	0	0.00308	0	0
OR2T8	343172	broad.mit.edu	37	1	248084593	248084593	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248084593C>A	uc010pzc.1	+	1	274	c.274C>A	c.(274-276)CGC>AGC	p.R92S		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCCATCTCCCGCGCTGGCTG	0.582			NA											16	17					5.60225e-13	7.96109e-13	0.009535	1	0
OR2L8	391190	broad.mit.edu	37	1	248112520	248112520	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248112520C>T	uc001idt.1	+	1	361	c.361C>T	c.(361-363)CGT>TGT	p.R121C	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGCCTATGATCGTTACATTGC	0.443			NA											33	322					0	0	0.010818	0	0
OR2L8	391190	broad.mit.edu	37	1	248112648	248112648	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248112648C>T	uc001idt.1	+	1	489	c.489C>T	c.(487-489)CTC>CTT	p.L163L	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TATATGTACTCCATATTCCTT	0.478			NA											19	154					0	0	0.008871	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129213	248129213	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248129213T>A	uc010pzd.1	+	1	580	c.580T>A	c.(580-582)TGT>AGT	p.C194S	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CCACTTTTTCTGTGAAGTTCC	0.433	Melanoma(45;390 1181 23848 28461 41504)		NA											48	44					0	0	0.01441	0	0
OR2L13	284521	broad.mit.edu	37	1	248263110	248263111	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:248263110_248263111GG>TT	uc001ids.2	+	3	770_771	c.433_434GG>TT	c.(433-435)GGA>TTA	p.G145L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GAAGATGATTGGAGGCTCTTGG	0.485			NA											82	275					0	0	0.004672	0	0
TUBB8	347688	broad.mit.edu	37	10	93393	93393	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:93393C>A	uc001ifi.2	-	4	939	c.939G>T	c.(937-939)GCG>GCT	p.A313A	TUBB8_uc009xhe.2_Silent_p.A276A|TUBB8_uc010pzs.1_Silent_p.A241A	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	313					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		AAATGGCAGCCGCCGTTAGGT	0.537	Pancreas(192;2041 3010 9013 18103)		NA											54	33					2.14255e-21	3.58567e-21	0.01441	1	0
CUBN	8029	broad.mit.edu	37	10	17146427	17146427	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:17146427G>A	uc001ioo.2	-	12	1460	c.1408C>T	c.(1408-1410)CCT>TCT	p.P470S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	470					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTTGCTGAGGAACCTGACAG	0.488			NA											11	25					0	0	0.013537	0	0
NSUN6	221078	broad.mit.edu	37	10	18931430	18931430	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:18931430A>T	uc010qcp.1	-	3	704	c.286T>A	c.(286-288)TTA>ATA	p.L96I		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	96							methyltransferase activity|RNA binding			ovary(2)	2						GGAATAAGTAACACATCTTGA	0.308			NA											34	67					0	0	0.003755	0	0
PARD3	56288	broad.mit.edu	37	10	34400396	34400396	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:34400396T>A	uc010qej.1	-	25	3772	c.3772A>T	c.(3772-3774)AGG>TGG	p.R1258W	PARD3_uc010qek.1_Missense_Mutation_p.R1255W|PARD3_uc010qel.1_Missense_Mutation_p.R1221W|PARD3_uc010qem.1_Missense_Mutation_p.R1242W|PARD3_uc010qen.1_Missense_Mutation_p.R1212W|PARD3_uc010qeo.1_Missense_Mutation_p.R1175W|PARD3_uc010qep.1_Missense_Mutation_p.R1168W|PARD3_uc010qeq.1_Missense_Mutation_p.R1146W|uc001ixe.1_5'Flank	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1258					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTGGAGTACCTGGGGTTCTCT	0.572			NA											60	28					0	0	0.01441	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37433954	37433954	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:37433954G>A	uc001iza.1	+	8	1356	c.1257G>A	c.(1255-1257)GAG>GAA	p.E419E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	475						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CCAAACAAGAGGAAGATGAAG	0.259			NA											61	33					0	0	0.01441	0	0
Unknown	0	broad.mit.edu	37	10	49218553	49218553	+	Missense_Mutation	SNP	T	T	C	rs77581903		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:49218553T>C	uc001jgd.2	-	8	1745	c.1586A>G	c.(1585-1587)CAT>CGT	p.H529R	uc001jge.1_5'Flank					RecName: Full=Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 11; AltName: Full=Centaurin-gamma-like protein KIAA1975;												NA						ATATTTGGAATGGATCCAGCG	0.567			NA											6	12					0	0	0.001984	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202626	118202626	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:118202626C>A	uc001lcl.3	+	3	365	c.264C>A	c.(262-264)ATC>ATA	p.I88I		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	88					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		CAGACAAGATCACCCGTATCA	0.383			NA											31	16					2.81731e-10	3.66885e-10	0.010818	1	0
MRGPRE	116534	broad.mit.edu	37	11	3249776	3249776	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:3249776A>C	uc001lxq.3	-	2	561	c.251T>G	c.(250-252)CTG>CGG	p.L84R		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	84	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCGGCCTTGCAGCAAGTCGGG	0.627			NA											25	32					0	0	0.005443	0	0
OR51D1	390038	broad.mit.edu	37	11	4661295	4661295	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:4661295C>A	uc010qyk.1	+	1	275	c.275C>A	c.(274-276)CCC>CAC	p.P92H		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCACCATGCCCAAGATGGCC	0.527			NA											27	38					2.79863e-10	3.66885e-10	0.004656	1	0
CCKBR	887	broad.mit.edu	37	11	6291448	6291448	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:6291448G>T	uc001mcp.2	+	3	727	c.534G>T	c.(532-534)ACG>ACT	p.T178T	CCKBR_uc001mcq.2_Silent_p.T106T|CCKBR_uc001mcr.2_Silent_p.T178T|CCKBR_uc001mcs.2_Silent_p.T178T	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	178	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TTGTAGCCACGTGGCTGCTGT	0.657			NA											24	21					2.41591e-17	3.76998e-17	0.004656	1	0
INSC	387755	broad.mit.edu	37	11	15243094	15243094	+	Silent	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:15243094T>A	uc001mly.2	+	8	1078	c.1032T>A	c.(1030-1032)GCT>GCA	p.A344A	INSC_uc001mlz.2_Silent_p.A297A|INSC_uc001mma.2_Silent_p.A297A|INSC_uc010rcs.1_Silent_p.A332A|INSC_uc001mmb.2_Silent_p.A297A|INSC_uc001mmc.2_Silent_p.A255A	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	344					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GGGCTGAGGCTGCGGCTGTGG	0.637			NA											35	31					0	0	0.003755	0	0
IGSF22	283284	broad.mit.edu	37	11	18731092	18731092	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:18731092C>A	uc009yht.2	-	18	3030	c.2840G>T	c.(2839-2841)TGG>TTG	p.W947L	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	846	Fibronectin type-III 2.									ovary(4)|large_intestine(2)|kidney(1)	7						GCACTTGGACCACTCCTTTGT	0.562			NA											36	37					1.414e-09	1.78402e-09	0.003755	1	0
SLC17A6	57084	broad.mit.edu	37	11	22387098	22387098	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:22387098T>C	uc001mqk.2	+	7	1167	c.754T>C	c.(754-756)TTT>CTT	p.F252L		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	252	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGCAGGAAGCTTTGGAATGGT	0.383			NA											6	95					0	0	0.001168	0	0
BBOX1	8424	broad.mit.edu	37	11	27078781	27078781	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:27078781G>A	uc001mre.1	+	4	621	c.253G>A	c.(253-255)GAA>AAA	p.E85K	BBOX1_uc009yih.1_Missense_Mutation_p.E85K|BBOX1_uc001mrg.1_Missense_Mutation_p.E85K	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	85					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	GCATTACAGTGAATTCCAGGC	0.403			NA											19	95					0	0	0.00278	0	0
DCDC1	341019	broad.mit.edu	37	11	31287134	31287134	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:31287134C>A	uc001msv.2	-	8	1176	c.974G>T	c.(973-975)TGT>TTT	p.C325F	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	325					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TCTTATTGTACAAGTATCTAA	0.234			NA											12	15					1.08611e-07	1.30915e-07	0.010729	1	0
CCDC73	493860	broad.mit.edu	37	11	32663549	32663549	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:32663549T>C	uc001mtv.2	-	13	1063	c.1019A>G	c.(1018-1020)CAT>CGT	p.H340R	CCDC73_uc001mtw.1_Missense_Mutation_p.H330R	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	340	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TGCTTTTTCATGCTCATTTTG	0.244			NA											7	26					0	0	0.00308	0	0
RAG1	5896	broad.mit.edu	37	11	36594888	36594888	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:36594888A>C	uc001mwu.3	+	2	158	c.34A>C	c.(34-36)AGT>CGT	p.S12R	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	12	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CTTGGGACTCAGTTCTGCCCC	0.433	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				6	69					0	0	0.001168	0	0
OR4C15	81309	broad.mit.edu	37	11	55322373	55322373	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:55322373G>A	uc010rig.1	+	1	591	c.591G>A	c.(589-591)CTG>CTA	p.L197L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTGGCATTCTGATGGGGGTAG	0.473			NA								HNSCC(20;0.049)			37	40					0	0	0.005524	0	0
OR8I2	120586	broad.mit.edu	37	11	55861237	55861237	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:55861237G>T	uc010rix.1	+	1	454	c.454G>T	c.(454-456)GGC>TGC	p.G152C		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					ATATGTGATAGGCTTCACAAG	0.443			NA											16	101					1.15088e-07	1.37494e-07	0.004007	1	0
OR5T1	390155	broad.mit.edu	37	11	56043390	56043390	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:56043390A>T	uc001nio.1	+	1	276	c.276A>T	c.(274-276)AAA>AAT	p.K92N		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TCACTCCAAAAATGTTGGTCA	0.373			NA											19	92					0	0	0.006122	0	0
CTNND1	1500	broad.mit.edu	37	11	57575995	57575995	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:57575995G>T	uc001nmc.3	+	14	2796	c.2225G>T	c.(2224-2226)CGC>CTC	p.R742L	CTNND1_uc001nlh.1_Missense_Mutation_p.R742L|CTNND1_uc001nlu.3_Missense_Mutation_p.R635L|CTNND1_uc001nlt.3_Missense_Mutation_p.R635L|CTNND1_uc001nls.3_Missense_Mutation_p.R635L|CTNND1_uc001nlw.3_Missense_Mutation_p.R635L|CTNND1_uc001nmf.3_Missense_Mutation_p.R742L|CTNND1_uc001nmd.3_Missense_Mutation_p.R688L|CTNND1_uc001nlk.3_Missense_Mutation_p.R688L|CTNND1_uc001nme.3_Missense_Mutation_p.R736L|CTNND1_uc001nll.3_Missense_Mutation_p.R682L|CTNND1_uc001nmg.3_Missense_Mutation_p.R682L|CTNND1_uc001nlj.3_Missense_Mutation_p.R682L|CTNND1_uc001nlr.3_Missense_Mutation_p.R682L|CTNND1_uc001nlp.3_Missense_Mutation_p.R682L|CTNND1_uc001nlx.3_Missense_Mutation_p.R419L|CTNND1_uc001nlz.3_Missense_Mutation_p.R419L|CTNND1_uc009ymn.2_Missense_Mutation_p.R413L|CTNND1_uc001nlm.3_Missense_Mutation_p.R736L|CTNND1_uc001nly.3_Missense_Mutation_p.R413L|CTNND1_uc001nmb.3_Missense_Mutation_p.R413L|CTNND1_uc001nma.3_Missense_Mutation_p.R413L|CTNND1_uc001nmi.3_Missense_Mutation_p.R641L|CTNND1_uc001nmh.3_Missense_Mutation_p.R736L|CTNND1_uc001nlq.3_Missense_Mutation_p.R641L|CTNND1_uc001nln.3_Missense_Mutation_p.R736L|CTNND1_uc001nli.3_Missense_Mutation_p.R736L|CTNND1_uc001nlo.3_Missense_Mutation_p.R635L|CTNND1_uc001nlv.3_Missense_Mutation_p.R635L	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	742	ARM 9.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				GTGGATGCTCGCAACAAAGAA	0.428			NA											38	25					4.14481e-20	6.76874e-20	0.00623	1	0
ZFP91	80829	broad.mit.edu	37	11	58385171	58385171	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:58385171G>T	uc001nmx.3	+	11	1873	c.1705G>T	c.(1705-1707)GGA>TGA	p.G569*	ZFP91_uc001nmy.3_Nonsense_Mutation_p.G568*|ZFP91-CNTF_uc010rkm.1_Intron	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	569					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AGACTCTGCCGGACCTTAGTG	0.308			NA											66	51					1.31311e-47	2.6069e-47	0.01441	1	0
RCE1	9986	broad.mit.edu	37	11	66613459	66613459	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:66613459T>C	uc001ojk.1	+	8	927	c.883T>C	c.(883-885)TTC>CTC	p.F295L	RCE1_uc001ojl.1_Missense_Mutation_p.F191L	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	295	Helical; (Potential).				proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						TGTGGGACTCTTCCTGCTTCT	0.627			NA											31	66					0	0	0.009535	0	0
P2RY6	5031	broad.mit.edu	37	11	73008427	73008427	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:73008427G>A	uc001otm.2	+	4	1269	c.864G>A	c.(862-864)CCG>CCA	p.P288P	P2RY6_uc001otn.2_Silent_p.P288P|P2RY6_uc001oto.2_Silent_p.P288P|P2RY6_uc001otp.2_Silent_p.P288P|P2RY6_uc001otq.2_Silent_p.P288P|P2RY6_uc001otr.2_Silent_p.P288P|P2RY6_uc001ots.2_Silent_p.P288P	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	288	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						GCACGCGGCCGTTTGCCAGTG	0.602			NA											5	50					0	0	0.000602	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74904298	74904298	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:74904298C>T	uc001owb.2	+	9	1498	c.1111C>T	c.(1111-1113)CCC>TCC	p.P371S	SLCO2B1_uc010rrq.1_Missense_Mutation_p.P116S|SLCO2B1_uc010rrr.1_Missense_Mutation_p.P227S|SLCO2B1_uc010rrs.1_Missense_Mutation_p.P255S|SLCO2B1_uc001owc.2_Missense_Mutation_p.P144S|SLCO2B1_uc001owd.2_Missense_Mutation_p.P349S	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	371	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	CCTACGCCACCCCATCTTCCT	0.627			NA											40	20					0	0	0.005524	0	0
GDPD4	220032	broad.mit.edu	37	11	76944186	76944186	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:76944186C>T	uc001oyf.2	-	13	1524	c.1273G>A	c.(1273-1275)GTA>ATA	p.V425I		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	425	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						ACGGTGTATACGTTGATATGG	0.438			NA											30	25					0	0	0.010818	0	0
CASP5	838	broad.mit.edu	37	11	104871047	104871047	+	Missense_Mutation	SNP	C	C	T	rs45464699	byFrequency	TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:104871047C>T	uc010rva.1	-	6	925	c.893G>A	c.(892-894)CGC>CAC	p.R298H	CASP5_uc010ruz.1_Missense_Mutation_p.R311H|CASP5_uc010rvb.1_Missense_Mutation_p.R240H|CASP5_uc010rvc.1_Missense_Mutation_p.R156H|CASP5_uc009yxh.2_Missense_Mutation_p.R80H|CASP5_uc010rvd.1_Missense_Mutation_p.R80H	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	298			R -> H.		apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GAGGCAGTTGCGGTTGTTGAA	0.468			NA											31	100					0	0	0.003271	0	0
FXYD2	486	broad.mit.edu	37	11	117693433	117693433	+	Splice_Site	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:117693433C>T	uc001prj.2	-	2	92	c.26_splice	c.e2-1	p.G9_splice	FXYD2_uc001prl.2_Intron|FXYD2_uc001prk.1_Splice_Site_p.G7_splice	NM_001680	NP_001671	P54710	ATNG_HUMAN	FXYD domain-containing ion transport regulator 2							sodium:potassium-exchanging ATPase complex	ion channel activity|sodium:potassium-exchanging ATPase activity				0	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;2.83e-05)|Epithelial(105;0.00114)	Cyclothiazide(DB00606)	GGGCTGCCGCCTAGGAGAGAG	0.637			NA											8	9					0	0	0.00308	0	0
CLEC12B	387837	broad.mit.edu	37	12	10168005	10168005	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:10168005G>T	uc001qwz.2	+	4	692	c.564G>T	c.(562-564)AAG>AAT	p.K188N	CLEC12B_uc001qwx.1_Missense_Mutation_p.K188N|CLEC12B_uc001qwy.1_Missense_Mutation_p.K85N|CLEC12B_uc009zhe.2_RNA	NM_001129998	NP_001123470	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B isoform	188	Extracellular (Potential).|C-type lectin.					integral to membrane|plasma membrane	receptor activity|sugar binding				0						TGGAAGAAAAGGTAGGATTGA	0.358			NA											5	35					3.59834e-05	3.99267e-05	0.001168	1	0
LRP6	4040	broad.mit.edu	37	12	12340001	12340001	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:12340001C>T	uc001rah.3	-	4	842	c.700G>A	c.(700-702)GAG>AAG	p.E234K	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.E234K	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	234	Extracellular (Potential).|Beta-propeller 1.|LDL-receptor class B 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AATATGTCCTCAAATAACGTC	0.393			NA											29	39					0	0	0.00632	0	0
CMAS	55907	broad.mit.edu	37	12	22214339	22214339	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:22214339G>T	uc001rfm.2	+	6	992	c.913G>T	c.(913-915)GTA>TTA	p.V305L	CMAS_uc001rfn.2_Intron	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	305					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						ATCTTATGATGTAAAAGATGC	0.313			NA											21	67					1.15919e-05	1.31137e-05	0.008871	1	0
FGD4	121512	broad.mit.edu	37	12	32735020	32735020	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:32735020G>A	uc001rkz.2	+	4	696	c.219G>A	c.(217-219)CAG>CAA	p.Q73Q	FGD4_uc001rlc.2_Silent_p.Q158Q|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Silent_p.Q185Q|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Silent_p.Q73Q	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	73	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					ACTTGCCACAGAGGCAGGGAA	0.493			NA											32	68					0	0	0.003755	0	0
NAV3	89795	broad.mit.edu	37	12	78443851	78443851	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:78443851C>A	uc001syp.2	+	10	2275	c.2102C>A	c.(2101-2103)TCC>TAC	p.S701Y	NAV3_uc001syo.2_Missense_Mutation_p.S701Y|NAV3_uc010sub.1_Missense_Mutation_p.S201Y	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	701	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GAGACTATGTCCAGTCTTCGT	0.328			NA								HNSCC(70;0.22)			25	19					4.22769e-11	5.66959e-11	0.00632	1	0
NAV3	89795	broad.mit.edu	37	12	78515872	78515872	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:78515872C>A	uc001syp.2	+	16	4075	c.3902C>A	c.(3901-3903)GCT>GAT	p.A1301D	NAV3_uc001syo.2_Missense_Mutation_p.A1301D|NAV3_uc010sub.1_Missense_Mutation_p.A801D|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1301	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATGGGCAGTGCTGGTGGGCTA	0.552			NA								HNSCC(70;0.22)			16	19					8.60227e-14	1.24426e-13	0.004007	1	0
C12orf50	160419	broad.mit.edu	37	12	88381709	88381709	+	Silent	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:88381709T>A	uc001tam.1	-	9	903	c.735A>T	c.(733-735)CTA>CTT	p.L245L	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	245										skin(2)|ovary(1)	3						GTCGGGTAGTTAGGGAATGCT	0.343			NA											24	19					0	0	0.00632	0	0
GALNT4	8693	broad.mit.edu	37	12	89918307	89918307	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:89918307C>G	uc001tbd.2	-	1	229	c.20G>C	c.(19-21)TGG>TCG	p.W7S	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	7	Cytoplasmic (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CTTGCCTGCCCAAGTCCACCT	0.627			NA									OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	17					0	0	0.00499	0	0
AMDHD1	144193	broad.mit.edu	37	12	96361533	96361533	+	Splice_Site	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:96361533G>C	uc001tel.1	+	9	1300	c.1194_splice	c.e9-1	p.R398_splice	AMDHD1_uc009zth.1_Splice_Site_p.R289_splice	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1						histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						TTTTTTTCTAGATGGGAGCAT	0.264			NA											5	6					0	0	0.001984	0	0
UBE3B	89910	broad.mit.edu	37	12	109921467	109921467	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:109921467G>T	uc001top.2	+	3	714	c.111G>T	c.(109-111)CAG>CAT	p.Q37H	UBE3B_uc001toq.2_Missense_Mutation_p.Q37H|UBE3B_uc001tol.1_Missense_Mutation_p.Q37H|UBE3B_uc001tom.2_Missense_Mutation_p.Q37H|UBE3B_uc001ton.2_Missense_Mutation_p.Q37H|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.Q37H|UBE3B_uc001tor.2_Missense_Mutation_p.Q37H	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	37	IQ.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TTGTGATCCAGGCCCATGTCC	0.532			NA											66	50					1.1794e-34	2.25311e-34	0.01441	1	0
TRPV4	59341	broad.mit.edu	37	12	110236693	110236693	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:110236693G>T	uc001tpj.1	-	5	973	c.878C>A	c.(877-879)GCC>GAC	p.A293D	TRPV4_uc001tpg.1_Missense_Mutation_p.A259D|TRPV4_uc001tph.1_Missense_Mutation_p.A246D|TRPV4_uc001tpi.1_Missense_Mutation_p.A246D|TRPV4_uc001tpk.1_Missense_Mutation_p.A293D|TRPV4_uc001tpl.1_Missense_Mutation_p.A293D	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	293	Cytoplasmic (Potential).|ANK 2.				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GTTGGTGCAGGCAGCCAGCGA	0.667			NA											27	31					8.16721e-17	1.2435e-16	0.010818	1	0
RBM19	9904	broad.mit.edu	37	12	114374839	114374839	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:114374839C>T	uc009zwi.2	-	16	2185	c.2041G>A	c.(2041-2043)GAA>AAA	p.E681K	RBM19_uc001tvn.3_Missense_Mutation_p.E681K|RBM19_uc001tvm.2_Missense_Mutation_p.E681K	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	681					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GGGTCCTTTTCCATGGGTTCT	0.567			NA											11	118					0	0	0.013537	0	0
MAP1LC3B2	643246	broad.mit.edu	37	12	117013775	117013775	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:117013775C>G	uc009zwk.1	+	2	182	c.28C>G	c.(28-30)CGG>GGG	p.R10G		NM_001085481	NP_001078950	A6NCE7	MP3B2_HUMAN	microtubule-associated protein 1 light chain 3	10					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule					0						CTTCAAGCAGCGGCGCACCTT	0.607			NA											14	62					0	0	0.00245	0	0
KSR2	283455	broad.mit.edu	37	12	117907527	117907527	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:117907527T>A	uc001two.2	-	19	2754	c.2699A>T	c.(2698-2700)GAG>GTG	p.E900V		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	929	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGCAGTTTCTCCAGCATGTC	0.483			NA											15	11					0	0	0.004007	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926753	130926753	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:130926753G>T	uc001uil.2	-	8	1257	c.1093C>A	c.(1093-1095)CGC>AGC	p.R365S	RIMBP2_uc001uim.2_Missense_Mutation_p.R273S|RIMBP2_uc001uin.1_Missense_Mutation_p.R24S	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	365	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ACGGAGATGCGGTAGGTGCAG	0.627			NA											40	26					2.2871e-25	4.00984e-25	0.007835	1	0
EP400	57634	broad.mit.edu	37	12	132529882	132529882	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr12:132529882A>G	uc001ujn.2	+	37	6838	c.6803A>G	c.(6802-6804)AAG>AGG	p.K2268R	EP400_uc001ujl.2_Missense_Mutation_p.K2267R|EP400_uc001ujm.2_Missense_Mutation_p.K2187R	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2304					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AGGAAGAAGAAGCAGCGTCAC	0.557			NA											6	24					0	0	0.001168	0	0
IFT88	8100	broad.mit.edu	37	13	21166539	21166539	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:21166539G>C	uc001unh.2	+	9	817	c.421G>C	c.(421-423)GAT>CAT	p.D141H	IFT88_uc001uni.2_Missense_Mutation_p.D132H|IFT88_uc001unj.2_Missense_Mutation_p.D131H|IFT88_uc010tcq.1_Missense_Mutation_p.D112H	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	141					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CAAGAAAAAAGATAGGTATGT	0.323			NA											3	37					0	0	0.009096	0	0
C13orf23	80209	broad.mit.edu	37	13	39586310	39586310	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:39586310C>A	uc001uwy.2	-	12	3495	c.2622G>T	c.(2620-2622)CCG>CCT	p.P874P	C13orf23_uc001uwz.2_Silent_p.P852P	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	874										ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		CAGGGATACCCGGGAGGGACA	0.453			NA											19	148					4.96729e-08	6.02321e-08	0.008871	1	0
DIAPH3	81624	broad.mit.edu	37	13	60485886	60485886	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:60485886C>T	uc001vht.2	-	20	2569	c.2350G>A	c.(2350-2352)GAG>AAG	p.E784K	DIAPH3_uc001vhu.2_Missense_Mutation_p.E521K|DIAPH3_uc001vhv.2_Missense_Mutation_p.E362K	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	784	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ACAAACTGCTCAGGTTCACAT	0.343			NA											19	25					0	0	0.007413	0	0
GPC5	2262	broad.mit.edu	37	13	92797141	92797141	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:92797141G>T	uc010tif.1	+	7	1826	c.1460G>T	c.(1459-1461)GGT>GTT	p.G487V		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	487						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CTGGGCAGTGGTGGAGGCATG	0.463			NA											25	55					8.24728e-16	1.24169e-15	0.004656	1	0
NALCN	259232	broad.mit.edu	37	13	101748033	101748033	+	Splice_Site	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:101748033T>C	uc001vox.1	-	28	3352	c.3163_splice	c.e28-1	p.E1055_splice		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1							integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCAATCTTCCTAAAGTAGAAA	0.378			NA											11	62					0	0	0.010729	0	0
DAOA	267012	broad.mit.edu	37	13	106119472	106119472	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:106119472A>T	uc001vqb.2	+	2	389	c.115A>T	c.(115-117)AAC>TAC	p.N39Y	DAOA_uc010tjf.1_5'UTR|DAOA_uc001vpz.2_RNA|DAOA_uc010agd.2_RNA|DAOA_uc010tjg.1_5'UTR|DAOA_uc001vqc.2_RNA|DAOA_uc001vqe.2_RNA	NM_172370	NP_758958	P59103	DAOA_HUMAN	D-amino acid oxidase activator isoform 1	39						Golgi apparatus					0	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					CAAATCTGAAAACTCTCTAAA	0.284			NA											8	62					0	0	0.004482	0	0
MYO16	23026	broad.mit.edu	37	13	109707460	109707460	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr13:109707460G>A	uc001vqt.1	+	26	3175	c.3049G>A	c.(3049-3051)GCA>ACA	p.A1017T	MYO16_uc010agk.1_Missense_Mutation_p.A1039T|MYO16_uc001vqu.1_Missense_Mutation_p.A817T|MYO16_uc010tjh.1_Missense_Mutation_p.A529T	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1017	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AGTCACCATAGCATCACAACT	0.328			NA											7	26					0	0	0.006214	0	0
OR4M1	441670	broad.mit.edu	37	14	20248996	20248996	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:20248996A>G	uc010tku.1	+	1	515	c.515A>G	c.(514-516)AAT>AGT	p.N172S		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGGGCCCAATGAGTTAGAC	0.498			NA											107	250					0	0	0.01441	0	0
NGDN	25983	broad.mit.edu	37	14	23944436	23944436	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:23944436G>A	uc001wjy.2	+	4	228	c.201G>A	c.(199-201)TTG>TTA	p.L67L	NGDN_uc001wjz.2_Silent_p.L67L|NGDN_uc001wka.2_5'Flank	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	67	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		TTATGGATTTGACCCACCTCA	0.458			NA											9	163					0	0	0.006214	0	0
FBXO34	55030	broad.mit.edu	37	14	55817595	55817595	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:55817595C>T	uc001xbu.2	+	2	732	c.487C>T	c.(487-489)CAG>TAG	p.Q163*	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Nonsense_Mutation_p.Q163*	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	163										ovary(2)|lung(2)|skin(1)	5						AGCCAAGGTACAGGTGGAAAG	0.438			NA											7	54					0	0	0.00308	0	0
PRKCH	5583	broad.mit.edu	37	14	61917613	61917613	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:61917613C>T	uc001xfn.2	+	6	1061	c.756C>T	c.(754-756)AAC>AAT	p.N252N	PRKCH_uc010tsa.1_Silent_p.N91N	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	252	Phorbol-ester/DAG-type 2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GCATCCACAACTACAAAGTGC	0.448	Melanoma(135;863 1779 8064 14443 26348)		NA											20	54					0	0	0.008871	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75388074	75388074	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:75388074G>T	uc010tux.1	-	2	699	c.171C>A	c.(169-171)ATC>ATA	p.I57I	RPS6KL1_uc001xqw.2_Silent_p.I57I|RPS6KL1_uc010asd.1_RNA|RPS6KL1_uc001xqy.1_Silent_p.I57I	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	57						ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GGGCCAGCCGGATCTGCGTGG	0.592			NA											19	81					7.45023e-12	1.02981e-11	0.010504	1	0
MLH3	27030	broad.mit.edu	37	14	75515141	75515141	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:75515141C>T	uc001xrd.1	-	2	1434	c.1218G>A	c.(1216-1218)TTG>TTA	p.L406L	MLH3_uc001xre.1_Silent_p.L406L|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	406					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		CTTTTGACTGCAAATTAAACA	0.353			NA						MMR					13	41					0	0	0.013537	0	0
TSHR	7253	broad.mit.edu	37	14	81534648	81534648	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:81534648A>G	uc001xvd.1	+	3	449	c.293A>G	c.(292-294)TAC>TGC	p.Y98C	TSHR_uc001xvb.1_Missense_Mutation_p.Y98C|TSHR_uc001xvc.2_Missense_Mutation_p.Y98C|TSHR_uc010tvs.1_Missense_Mutation_p.Y98C	NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	98	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CACTCCTTCTACAATTTGAGT	0.403			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						14	47					0	0	0.004007	0	0
BTBD7	55727	broad.mit.edu	37	14	93709365	93709365	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:93709365C>A	uc001ybo.2	-	11	2979	c.2653G>T	c.(2653-2655)GAC>TAC	p.D885Y	BTBD7_uc010aur.2_Missense_Mutation_p.D410Y|BTBD7_uc010two.1_Missense_Mutation_p.D705Y|BTBD7_uc001ybp.2_Missense_Mutation_p.D534Y	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	885										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		AGCCTCCTGTCCTTGAGTGAC	0.532			NA											19	163					6.94344e-10	8.89903e-10	0.006122	1	0
KIAA1409	57578	broad.mit.edu	37	14	94139777	94139777	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:94139777T>A	uc001ybv.1	+	40	6452	c.6369T>A	c.(6367-6369)GAT>GAA	p.D2123E	KIAA1409_uc001ybs.1_Missense_Mutation_p.D2101E	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2278						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTTTACCAGATACAAACCTTC	0.378			NA											24	146					0	0	0.007291	0	0
TCL1B	9623	broad.mit.edu	37	14	96157078	96157078	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:96157078A>C	uc001yez.2	+	2	210	c.168A>C	c.(166-168)GAA>GAC	p.E56D	TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_RNA|TCL1B_uc001yfa.2_Missense_Mutation_p.E56D	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	56										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		TTCAGTATGAACCCAGCATCA	0.602			NA											5	145					0	0	0.001168	0	0
BEGAIN	57596	broad.mit.edu	37	14	101004814	101004814	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:101004814T>C	uc010txa.1	-	6	1420	c.1274A>G	c.(1273-1275)GAC>GGC	p.D425G	BEGAIN_uc001yhp.2_Missense_Mutation_p.D361G|BEGAIN_uc001yhq.2_Missense_Mutation_p.D425G	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	425						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GGCGCCGATGTCCTCCACGCT	0.731	NSCLC(159;1889 2010 9965 27479 40101)		NA											5	15					0	0	0.001168	0	0
ADAM6	8755	broad.mit.edu	37	14	106805666	106805666	+	Splice_Site	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr14:106805666G>T	uc010tyt.1	-	359		c.13625_splice	c.e359-1		uc001ysw.1_5'Flank					Parts of antibodies, mostly variable regions.												0						GGAGGTCCAGGACTCTCAGAA	0.498			NA											10	14					4.14922e-12	5.7946e-12	0.004007	1	0
OR4N4	283694	broad.mit.edu	37	15	22382661	22382661	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:22382661G>T	uc001yuc.1	+	7	1170	c.189G>T	c.(187-189)CTG>CTT	p.L63L	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Silent_p.L63L	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATTTATTTCTGGGCAACTTGG	0.458			NA											13	232					6.97489e-18	1.12096e-17	0.004878	1	0
C15orf2	23742	broad.mit.edu	37	15	24923271	24923271	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:24923271G>T	uc001ywo.2	+	1	2731	c.2257G>T	c.(2257-2259)GTC>TTC	p.V753F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	753					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGCACAGTCAGTCAGGGCACC	0.567			NA											78	65					1.75807e-36	3.37449e-36	0.01441	1	0
MYEF2	50804	broad.mit.edu	37	15	48435217	48435217	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:48435217C>A	uc001zwi.3	-	17	1815	c.1691G>T	c.(1690-1692)TGT>TTT	p.C564F	MYEF2_uc001zwg.3_Missense_Mutation_p.C102F|MYEF2_uc001zwh.3_Missense_Mutation_p.C152F|MYEF2_uc001zwj.3_Missense_Mutation_p.C540F	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	564	RRM 3.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		GACTGTTCCACAGCCTTTTGA	0.348			NA											21	17					7.45023e-12	1.02981e-11	0.010504	1	0
C15orf39	56905	broad.mit.edu	37	15	75499431	75499431	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:75499431G>T	uc002azp.3	+	2	1362	c.1042G>T	c.(1042-1044)GCC>TCC	p.A348S	C15orf39_uc002azq.3_Missense_Mutation_p.A348S|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	348											0						CTACCCCTCTGCCCCTCTCCC	0.647			NA											51	37					1.89013e-27	3.40223e-27	0.01441	1	0
MEX3B	84206	broad.mit.edu	37	15	82336286	82336286	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:82336286C>A	uc002bgq.1	-	2	1240	c.925G>T	c.(925-927)GCA>TCA	p.A309S		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	309					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						GTAGCCGCTGCGCTGCTGCTG	0.617			NA											27	23					1.42536e-11	1.95684e-11	0.004656	1	0
OR4F15	390649	broad.mit.edu	37	15	102358587	102358587	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr15:102358587C>A	uc010uts.1	+	1	198	c.198C>A	c.(196-198)CTC>CTA	p.L66L		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGGCTAACCTCTCAATCATTG	0.428			NA											52	85					1.63038e-21	2.73985e-21	0.01441	1	0
PTX4	390667	broad.mit.edu	37	16	1537678	1537678	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:1537678G>T	uc010uvf.1	-	2	420	c.420C>A	c.(418-420)GCC>GCA	p.A140A		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	145						extracellular region	metal ion binding				0						CGTCCCTCTGGGCCTTGTGTG	0.726			NA											16	15					1.37522e-17	2.17565e-17	0.007413	1	0
GPR139	124274	broad.mit.edu	37	16	20043958	20043958	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:20043958A>T	uc002dgu.1	-	2	323	c.161T>A	c.(160-162)CTG>CAG	p.L54Q	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	54	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						TCTTGCCACCAGCTGGGAGAG	0.483			NA											20	13					0	0	0.014323	0	0
ACSM5	54988	broad.mit.edu	37	16	20429402	20429402	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:20429402C>A	uc002dhe.2	+	3	373	c.226C>A	c.(226-228)CCT>ACT	p.P76T	ACSM5_uc002dhd.1_Missense_Mutation_p.P76T	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	76					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CCCCCCAAATCCTGCCTTCTG	0.493			NA											10	9					0.000673444	0.000708428	0.008291	1	0
KIAA0556	23247	broad.mit.edu	37	16	27585278	27585278	+	Splice_Site	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:27585278G>T	uc002dow.2	+	2	87	c.63_splice	c.e2+1	p.E21_splice		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247											ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GAAAAAGGAGGTAAATGTGTC	0.493			NA											8	55					1.12685e-05	1.28195e-05	0.004482	1	0
ZNF423	23090	broad.mit.edu	37	16	49669627	49669627	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:49669627G>T	uc002efs.2	-	5	3734	c.3436C>A	c.(3436-3438)CTC>ATC	p.L1146I	ZNF423_uc010vgn.1_Missense_Mutation_p.L1029I	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1146					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TCCGGCGTGAGGTCACGGTGG	0.662			NA											38	60					3.38236e-24	5.8792e-24	0.006999	1	0
NLRC5	84166	broad.mit.edu	37	16	57111855	57111855	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:57111855G>T	uc002ekk.1	+	43	5229	c.5004G>T	c.(5002-5004)ATG>ATT	p.M1668I	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Missense_Mutation_p.M210I|NLRC5_uc002ekr.1_Missense_Mutation_p.M555I	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1668	LRR 22.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CCTCTTCCAGGCTTGGCTGCA	0.677			NA											8	21					6.40141e-05	6.96928e-05	0.010729	1	0
DPEP3	64180	broad.mit.edu	37	16	68012481	68012481	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:68012481G>T	uc002evc.3	-	3	632	c.538C>A	c.(538-540)CGC>AGC	p.R180S	DPEP3_uc010cex.2_Missense_Mutation_p.R180S	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	155					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		AGGGCGAGGCGCACGGCAGTC	0.607			NA											56	59					2.78941e-39	5.4313e-39	0.01441	1	0
TAT	6898	broad.mit.edu	37	16	71604626	71604626	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:71604626C>A	uc002fap.2	-	8	967	c.868G>T	c.(868-870)GGC>TGC	p.G290C		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	290					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	AGGATCCAGCCCAACCTCCAG	0.488	Melanoma(198;542 2142 10292 21661 50033)|Esophageal Squamous(48;487 1013 5572 44395 52594)		NA											17	12					1.50039e-11	2.0529e-11	0.012319	1	0
CA5A	763	broad.mit.edu	37	16	87936058	87936058	+	Silent	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr16:87936058A>T	uc002fkn.1	-	4	584	c.528T>A	c.(526-528)GGT>GGA	p.G176G		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	176					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		TCACAGCCAAACCATTCTCTC	0.368			NA											10	59					0	0	0.010729	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Silent	SNP	C	C	A	rs55863639		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	29					1.465e-08	1.80892e-08	0.00874	1	0
MYH2	4620	broad.mit.edu	37	17	10439865	10439865	+	Silent	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:10439865T>G	uc010coi.2	-	17	2084	c.1956A>C	c.(1954-1956)ACA>ACC	p.T652T	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.T652T|MYH2_uc010coj.2_Silent_p.T652T	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	652	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GGGCAGACACTGTCTGGAAAG	0.343			NA											13	12					0	0	0.001855	0	0
DNAH9	1770	broad.mit.edu	37	17	11787015	11787015	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:11787015T>C	uc002gne.2	+	56	10987	c.10919T>C	c.(10918-10920)CTG>CCG	p.L3640P	DNAH9_uc010coo.2_Missense_Mutation_p.L2934P|DNAH9_uc002gnf.2_5'UTR|DNAH9_uc010vvh.1_5'Flank	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3640	Potential.|AAA 5 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAAACAGTGCTGGTGGAAAAC	0.512			NA											42	27					0	0	0.01441	0	0
NF1	4763	broad.mit.edu	37	17	29553702	29553702	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:29553702G>T	uc002hgg.2	+	18	2584	c.2251G>T	c.(2251-2253)GGA>TGA	p.G751*	NF1_uc002hgh.2_Nonsense_Mutation_p.G751*|NF1_uc010csn.1_Nonsense_Mutation_p.G611*|NF1_uc002hgi.1_Translation_Start_Site	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	751					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GATGTCAACAGGTAAATGTGA	0.403			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			64	44					1.46168e-27	2.64277e-27	0.01441	1	0
SPACA3	124912	broad.mit.edu	37	17	31318959	31318959	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:31318959G>T	uc002hhs.1	+	1	78	c.3G>T	c.(1-3)ATG>ATT	p.M1I	SPACA3_uc010cte.1_5'Flank	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	1	Cytoplasmic (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			TTGTCACCATGGTCTCAGCTC	0.607			NA											14	6					3.41278e-10	4.4159e-10	0.00499	1	0
DDX52	11056	broad.mit.edu	37	17	35979858	35979858	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:35979858C>A	uc002hoi.1	-	13	1642	c.1604G>T	c.(1603-1605)GGG>GTG	p.G535V	DDX52_uc002hoh.1_Missense_Mutation_p.G427V	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	535	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				TACAGGACACCCAGCCTGCTG	0.333			NA											25	20					1.55811e-20	2.57565e-20	0.008361	1	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324029	39324029	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:39324029G>T	uc010cxl.2	-	1	396	c.396C>A	c.(394-396)CCC>CCA	p.P132P		NM_033187	NP_149443	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	132	29 X 5 AA repeats of C-C-[GIKRQVH]-[SPT]- [STA].|20.		Missing (in allele KAP3-v2).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			TACAGCAGCTGGGGCGGCAGC	0.622			NA											8	3					0.000442599	0.000472962	0.006214	1	0
KRT33A	3883	broad.mit.edu	37	17	39506806	39506806	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:39506806C>A	uc002hwk.1	-	1	251	c.214G>T	c.(214-216)GAG>TAG	p.E72*		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	72	Coil 1A.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CGCACCTTCTCCAGGTAGCTG	0.607			NA											34	30					9.88483e-10	1.26289e-09	0.007835	1	0
KIF2B	84643	broad.mit.edu	37	17	51901793	51901793	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:51901793G>T	uc002iua.2	+	1	1555	c.1399G>T	c.(1399-1401)GAA>TAA	p.E467*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	467	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AAGGCAGCTGGAAGGGGCAGA	0.493			NA											13	12					1.61879e-10	2.14954e-10	0.013537	1	0
RECQL5	9400	broad.mit.edu	37	17	73627305	73627305	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr17:73627305G>A	uc010dgl.2	-	10	1629	c.1473C>T	c.(1471-1473)AGC>AGT	p.S491S	RECQL5_uc010dgk.2_Silent_p.S464S|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	491					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTTCATCCCCGCTGCCTCCAG	0.617			NA						Other_identified_genes_with_known_or_suspected_DNA_repair_function					15	50					0	0	0.003163	0	0
LAMA1	284217	broad.mit.edu	37	18	7080334	7080334	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr18:7080334G>T	uc002knm.2	-	2	278	c.184C>A	c.(184-186)CGA>AGA	p.R62R	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	62	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTGGGTTTCGGACGGGCCGA	0.552			NA											24	32					3.01185e-09	3.76481e-09	0.003954	1	0
MC2R	4158	broad.mit.edu	37	18	13884841	13884841	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr18:13884841C>A	uc002ksp.1	-	2	854	c.677G>T	c.(676-678)GGG>GTG	p.G226V		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	226	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GATGAAGACCCCGAGCAGGAT	0.552	Colon(141;1584 1782 35999 48227 48692)		NA											25	11					7.87624e-14	1.14744e-13	0.00278	1	0
ASXL3	80816	broad.mit.edu	37	18	31323882	31323882	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr18:31323882C>A	uc010dmg.1	+	12	4125	c.4070C>A	c.(4069-4071)TCT>TAT	p.S1357Y	ASXL3_uc002kxq.2_Missense_Mutation_p.S1064Y	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1357	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCCACTAGCTCTGTCTTGATT	0.468			NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	75	64					6.06247e-24	1.04927e-23	0.01441	1	0
TNFRSF11A	8792	broad.mit.edu	37	18	60036389	60036389	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr18:60036389G>T	uc002lin.2	+	9	1277	c.1239G>T	c.(1237-1239)TGG>TGT	p.W413C	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	413	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				GGACTGATTGGACTCCCATGT	0.567			NA							Paget_Disease_of_Bone				24	18					1.64293e-13	2.35953e-13	0.00333	1	0
MUC16	94025	broad.mit.edu	37	19	9063963	9063963	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:9063963G>T	uc002mkp.2	-	3	23687	c.23483C>A	c.(23482-23484)TCC>TAC	p.S7828Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7830	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGGGTCAGGGAGGAAGCTAG	0.542			NA											32	60					3.99451e-17	6.19837e-17	0.009535	1	0
MUC16	94025	broad.mit.edu	37	19	9067932	9067932	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:9067932A>T	uc002mkp.2	-	3	19718	c.19514T>A	c.(19513-19515)GTG>GAG	p.V6505E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6507	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTTTTTTCCACAGAGGGTGG	0.473			NA											6	26					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9088957	9088957	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:9088957C>A	uc002mkp.2	-	1	3062	c.2858G>T	c.(2857-2859)AGA>ATA	p.R953I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	953	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAACGTGTCTCTATTGGTCTG	0.473			NA											92	63					1.38319e-45	2.71937e-45	0.01441	1	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10225118	10225118	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:10225118C>A	uc002mna.2	+	13	2089	c.2089C>A	c.(2089-2091)CGC>AGC	p.R697S	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Missense_Mutation_p.R277S	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGCTCGGCGGCGCTGGAGCAC	0.667			NA											35	16					6.70999e-13	9.5019e-13	0.004289	1	0
KEAP1	9817	broad.mit.edu	37	19	10602727	10602727	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:10602727T>A	uc002moq.1	-	3	1007	c.851A>T	c.(850-852)CAG>CTG	p.Q284L	KEAP1_uc002mop.1_Missense_Mutation_p.Q2L|KEAP1_uc002mor.1_Missense_Mutation_p.Q284L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	284	BACK.		Q -> L (in a lung adenocarcinoma patient).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CTTCTGCAGCTGCATCTGCAG	0.612			NA											21	17					0	0	0.012319	0	0
DNM2	1785	broad.mit.edu	37	19	10886572	10886572	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:10886572C>T	uc002mps.1	+	4	743	c.579C>T	c.(577-579)GTC>GTT	p.V193V	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.V193V|DNM2_uc002mpv.1_Silent_p.V193V|DNM2_uc002mpu.1_Silent_p.V193V|DNM2_uc010dxl.1_Silent_p.V193V	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	193					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CCAAGGAAGTCGATCCCCAAG	0.607			NA											4	26					0	0	0.009096	0	0
SLC1A6	6511	broad.mit.edu	37	19	15064949	15064949	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:15064949G>A	uc002naa.1	-	7	1370	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	SLC1A6_uc010dzu.1_Silent_p.I376I|SLC1A6_uc010xod.1_Silent_p.I390I	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	454					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CCCCTCACCTGATGGTTGTGA	0.592			NA											29	20					0	0	0.007291	0	0
NOTCH3	4854	broad.mit.edu	37	19	15291560	15291560	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:15291560G>T	uc002nan.2	-	19	3150	c.3074C>A	c.(3073-3075)CCC>CAC	p.P1025H	NOTCH3_uc002nao.1_Missense_Mutation_p.P973H	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1025	Extracellular (Potential).|EGF-like 26.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCATCCAGGGGGACAAAGGCA	0.657			NA											5	8					0.000602214	0.000636806	0.000602	1	0
UNC13A	23025	broad.mit.edu	37	19	17758168	17758168	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:17758168C>A	uc002nhd.2	-	17	2214	c.2214G>T	c.(2212-2214)GCG>GCT	p.A738A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	650					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TCTTGGTCACCGCGAAGATCT	0.597			NA											7	12					0.00198382	0.00206541	0.001984	1	0
CRLF1	9244	broad.mit.edu	37	19	18710443	18710443	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:18710443G>T	uc010ebt.1	-	2	523	c.329C>A	c.(328-330)TCG>TAG	p.S110*		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	110	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GTTGTCCCCCGACCGCTGCCT	0.672			NA											10	24					1.58986e-06	1.86097e-06	0.008291	1	0
KLHL26	55295	broad.mit.edu	37	19	18778916	18778916	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:18778916G>T	uc002njz.1	+	3	736	c.709G>T	c.(709-711)GAC>TAC	p.D237Y		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	237	BACK.									ovary(1)	1						GCTGCAGCATGAcccggcccg	0.577			NA											9	27					2.74318e-10	3.61885e-10	0.006214	1	0
ZNF429	353088	broad.mit.edu	37	19	21720876	21720876	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:21720876G>T	uc002nqd.1	+	4	2158	c.2021G>T	c.(2020-2022)GGC>GTC	p.G674V	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						gaccgtcctggctaacatggt	0.015			NA											14	10					9.31168e-06	1.06532e-05	0.001855	1	0
RYR1	6261	broad.mit.edu	37	19	38949803	38949803	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:38949803G>T	uc002oit.2	+	19	2315	c.2185G>T	c.(2185-2187)GTG>TTG	p.V729L	RYR1_uc002oiu.2_Missense_Mutation_p.V729L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	729	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCACGCCCAGTGACTTCCCC	0.587			NA											10	14					6.40141e-05	6.96928e-05	0.010729	1	0
TMEM145	284339	broad.mit.edu	37	19	42821933	42821933	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:42821933G>T	uc002otk.1	+	12	1025	c.973G>T	c.(973-975)GCG>TCG	p.A325S		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	325	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				ACTGCAGGTGGCGGCCTACGT	0.562			NA											28	13					4.22769e-11	5.66959e-11	0.00632	1	0
ZNF285	26974	broad.mit.edu	37	19	44891284	44891284	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:44891284C>A	uc002ozd.3	-	4	1210	c.1123G>T	c.(1123-1125)GAA>TAA	p.E375*	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Nonsense_Mutation_p.E382*	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	375	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						CCACACTCTTCACATTTATAG	0.468			NA											14	15					0.000151284	0.000163387	0.001855	1	0
PLA2G4C	8605	broad.mit.edu	37	19	48558213	48558213	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:48558213C>A	uc002phx.2	-	15	1749	c.1351G>T	c.(1351-1353)GCC>TCC	p.A451S	PLA2G4C_uc002phv.2_RNA|PLA2G4C_uc002phw.2_Missense_Mutation_p.A386S|PLA2G4C_uc010elr.2_Missense_Mutation_p.A451S|PLA2G4C_uc010xzd.1_Missense_Mutation_p.A461S	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	451	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TAGCAGCTGGCGGGGGCCTTG	0.567			NA											24	24					1.85244e-09	2.32993e-09	0.00333	1	0
AP2A1	160	broad.mit.edu	37	19	50296349	50296349	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:50296349G>T	uc002ppn.2	+	6	916	c.705G>T	c.(703-705)CGG>CGT	p.R235R	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.R235R	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	235					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		GCCTGAGCCGGGTGGGTGTGG	0.597			NA											7	3					0.00307968	0.00318995	0.00308	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51628941	51628941	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:51628941G>T	uc002pvu.2	+	2	576	c.509G>T	c.(508-510)TGT>TTT	p.C170F	SIGLEC9_uc010yct.1_Missense_Mutation_p.C170F	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	170	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CCCTGGGCCTGTGAGCAGGGG	0.652			NA											51	83					5.13769e-22	8.70612e-22	0.01441	1	0
ZNF71	58491	broad.mit.edu	37	19	57133832	57133832	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:57133832G>T	uc002qnm.3	+	3	1415	c.1177G>T	c.(1177-1179)GGG>TGG	p.G393W		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	393	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCACTTCACGGGGCGCTCGTC	0.632			NA											20	10					2.39187e-15	3.56143e-15	0.008871	1	0
ZSCAN4	201516	broad.mit.edu	37	19	58189585	58189585	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr19:58189585T>A	uc002qpu.2	+	5	1311	c.614T>A	c.(613-615)GTA>GAA	p.V205E		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	205					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTACTCGAGTAAATGAAAAT	0.398			NA											13	10					0	0	0.001855	0	0
APOB	338	broad.mit.edu	37	2	21228767	21228767	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:21228767T>G	uc002red.2	-	26	11101	c.10973A>C	c.(10972-10974)CAC>CCC	p.H3658P		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3658					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATGTCAAGGTGTGCCTTTTC	0.433			NA											36	15					0	0	0.003271	0	0
GALNT14	79623	broad.mit.edu	37	2	31189075	31189075	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:31189075G>T	uc002rnr.2	-	3	1012	c.393C>A	c.(391-393)ATC>ATA	p.I131I	GALNT14_uc002rnq.2_Silent_p.I111I|GALNT14_uc002rns.2_Silent_p.I136I|GALNT14_uc010ymr.1_Silent_p.I96I|GALNT14_uc010ezo.1_Intron|GALNT14_uc010ezp.1_Silent_p.I102I	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	131	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					CTCACCTGCGGATGGTCCTGA	0.602			NA											19	10					7.45023e-12	1.02981e-11	0.010504	1	0
LTBP1	4052	broad.mit.edu	37	2	33442709	33442709	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:33442709C>A	uc002ros.2	+	8	1792	c.1792C>A	c.(1792-1794)CCC>ACC	p.P598T	LTBP1_uc002rot.2_Missense_Mutation_p.P272T|LTBP1_uc002rou.2_Missense_Mutation_p.P272T|LTBP1_uc002rov.2_Missense_Mutation_p.P272T|LTBP1_uc010ymz.1_Missense_Mutation_p.P272T|LTBP1_uc010yna.1_Missense_Mutation_p.P272T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	598	TB 1.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCAGAAATGCCCCAAGAAACC	0.433			NA											25	9					1.26454e-06	1.48446e-06	0.005443	1	0
EIF2AK2	5610	broad.mit.edu	37	2	37349652	37349652	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:37349652G>C	uc010ynh.1	-	12	1621	c.1064C>G	c.(1063-1065)TCA>TGA	p.S355*	EIF2AK2_uc010fab.1_Nonsense_Mutation_p.S314*|EIF2AK2_uc010yng.1_Nonsense_Mutation_p.S355*|EIF2AK2_uc010fac.2_Nonsense_Mutation_p.S355*|EIF2AK2_uc010fad.2_Intron	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	355	2.|2 X 13 AA approximate repeats.|Protein kinase.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TAGTTACCTTGAACTATTTTT	0.363			NA											10	72					0	0	0.008291	0	0
NRXN1	9378	broad.mit.edu	37	2	50723056	50723056	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:50723056G>T	uc010fbq.2	-	15	4654	c.3177C>A	c.(3175-3177)AAC>AAA	p.N1059K	NRXN1_uc002rxb.3_Missense_Mutation_p.N691K|NRXN1_uc002rxe.3_Missense_Mutation_p.N1019K|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGAGGTCTAAGTTCCTGGCTC	0.478			NA											6	39					8.12818e-05	8.82551e-05	0.001984	1	0
CLEC4F	165530	broad.mit.edu	37	2	71043709	71043709	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:71043709C>G	uc002shf.2	-	4	881	c.804G>C	c.(802-804)AGG>AGC	p.R268S	CLEC4F_uc010yqv.1_Missense_Mutation_p.R268S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	268	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GGTTCTGGGTCCTCAAGTCAT	0.423	Colon(107;10 2157 6841 26035)		NA											97	41					0	0	0.01441	0	0
ALMS1	7840	broad.mit.edu	37	2	73678721	73678721	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:73678721G>T	uc002sje.1	+	10	5181	c.5070G>T	c.(5068-5070)CTG>CTT	p.L1690L	ALMS1_uc002sjf.1_Silent_p.L1646L|ALMS1_uc002sjg.2_Silent_p.L1076L|ALMS1_uc002sjh.1_Silent_p.L1076L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1688	25.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AAGAAGCTCTGAAAGTTCCAC	0.443			NA											78	35					4.75426e-39	9.16892e-39	0.01441	1	0
C2orf78	388960	broad.mit.edu	37	2	74040979	74040979	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:74040979C>A	uc002sjr.1	+	2	594	c.473C>A	c.(472-474)TCC>TAC	p.S158Y		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	158										ovary(2)	2						GCTGTCTCTTCCATGTCTATG	0.448			NA											31	8					8.16721e-17	1.2435e-16	0.010818	1	0
PROM2	150696	broad.mit.edu	37	2	95941743	95941743	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:95941743G>T	uc002suh.1	+	3	493	c.360G>T	c.(358-360)GTG>GTT	p.V120V	PROM2_uc002sui.2_Silent_p.V120V|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.V120V|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	120	Helical; (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						TGCTGCTGGTGCCCACTGCCG	0.701			NA											6	33					0.00116845	0.00122596	0.001168	1	0
ZAP70	7535	broad.mit.edu	37	2	98341688	98341688	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:98341688C>T	uc002syd.1	+	4	743	c.536C>T	c.(535-537)TCT>TTT	p.S179F	ZAP70_uc010yvf.1_Missense_Mutation_p.S179F|ZAP70_uc002sye.1_Missense_Mutation_p.S69F	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	179	SH2 2.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						AAACTTTACTCTGGGGCGCAG	0.652			NA											6	109					0	0	0.001168	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124783245	124783245	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:124783245G>T	uc002tno.2	+	1	382	c.18G>T	c.(16-18)CGG>CGT	p.R6R	CNTNAP5_uc010flu.2_Silent_p.R6R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	6					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTTTACCACGGCTGACCAGCG	0.552			NA											14	53					1.05317e-09	1.33292e-09	0.00245	1	0
NCKAP5	344148	broad.mit.edu	37	2	133483297	133483297	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:133483297G>T	uc002ttp.2	-	19	5990	c.5616C>A	c.(5614-5616)AGC>AGA	p.S1872R	NCKAP5_uc002ttq.2_Missense_Mutation_p.S553R	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1872							protein binding				0						TACTGCCACCGCTGGCAGAGT	0.458			NA											6	19					3.59834e-05	3.99267e-05	0.001168	1	0
LCT	3938	broad.mit.edu	37	2	136570190	136570190	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:136570190C>A	uc002tuu.1	-	7	2055	c.2044G>T	c.(2044-2046)GGT>TGT	p.G682C		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	682	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGCGACAGACCCAGAAAATCA	0.537			NA											11	53					0.000673444	0.000708428	0.008291	1	0
LCT	3938	broad.mit.edu	37	2	136594342	136594342	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:136594342T>C	uc002tuu.1	-	1	409	c.398A>G	c.(397-399)CAC>CGC	p.H133R		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	133	Extracellular (Potential).|4 X approximate repeats.|1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGGGTCTGGTGGTGCAGGAT	0.597			NA											10	26					0	0	0.010729	0	0
LRP1B	53353	broad.mit.edu	37	2	141272306	141272306	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:141272306C>T	uc002tvj.1	-	51	9157	c.8185G>A	c.(8185-8187)GCA>ACA	p.A2729T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2729	Extracellular (Potential).|LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTTTTGTGCGGAACAAGCA	0.338	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	26					0	0	0.004482	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555721	155555721	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:155555721G>C	uc002tyv.1	+	1	629	c.434G>C	c.(433-435)GGC>GCC	p.G145A	KCNJ3_uc010zce.1_Missense_Mutation_p.G145A	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	145	Selectivity filter (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	GCCACCATCGGCTATGGCTAC	0.562			NA											17	28					0	0	0.007413	0	0
XIRP2	129446	broad.mit.edu	37	2	168108351	168108351	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:168108351G>T	uc002udx.2	+	8	10467	c.10449G>T	c.(10447-10449)ACG>ACT	p.T3483T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T3308T|XIRP2_uc010fpq.2_Silent_p.T3261T|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3308					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTCAAAAGACGTGGCAAGAGA	0.413			NA											18	35					5.35267e-07	6.3202e-07	0.007413	1	0
ZAK	51776	broad.mit.edu	37	2	174131278	174131278	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:174131278A>G	uc002uhz.2	+	20	2403	c.2203A>G	c.(2203-2205)AGG>GGG	p.R735G	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	735					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			GAGAAGCCCCAGGGACCTCCA	0.542			NA											17	35					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179435936	179435936	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:179435936C>G	uc010zfg.1	-	275	67443	c.67219G>C	c.(67219-67221)GAA>CAA	p.E22407Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E16102Q|TTN_uc010zfi.1_Missense_Mutation_p.E16035Q|TTN_uc010zfj.1_Missense_Mutation_p.E15910Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23334							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAACACCTTCTTCAAGGCCA	0.418			NA											6	102					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179588619	179588619	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:179588619C>A	uc010zfg.1	-	70	17859	c.17635G>T	c.(17635-17637)GGG>TGG	p.G5879W	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G2540W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6806							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATCAGACCCAGCGACATTA	0.423			NA											16	48					1.15088e-07	1.37494e-07	0.004007	1	0
PARD3B	117583	broad.mit.edu	37	2	205829880	205829880	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:205829880T>G	uc002var.1	+	3	435	c.228T>G	c.(226-228)ATT>ATG	p.I76M	PARD3B_uc010fub.1_Missense_Mutation_p.I76M|PARD3B_uc002vao.1_Missense_Mutation_p.I76M|PARD3B_uc002vap.1_Missense_Mutation_p.I76M|PARD3B_uc002vaq.1_Missense_Mutation_p.I76M	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	76					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TGTAGCTGATTGCTGTGTTTG	0.453			NA											5	14					0	0	0.001168	0	0
VWC2L	402117	broad.mit.edu	37	2	215279259	215279259	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:215279259C>A	uc002vet.2	+	2	472	c.342C>A	c.(340-342)AAC>AAA	p.N114K	VWC2L_uc010zjl.1_Missense_Mutation_p.N114K	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	114	VWFC 2.					extracellular region					0						AAGTAAAAAACTTCTGTGAAT	0.383			NA											14	7					4.3838e-07	5.19134e-07	0.001855	1	0
XRCC5	7520	broad.mit.edu	37	2	216981433	216981433	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:216981433G>T	uc002vfy.2	+	3	327	c.187G>T	c.(187-189)GGC>TGC	p.G63C	XRCC5_uc002vfz.2_5'Flank	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	63					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		TGGTACAGATGGCACTGACAA	0.418			NA						Direct_reversal_of_damage|NHEJ					28	71					2.41591e-17	3.76998e-17	0.004656	1	0
SLC11A1	6556	broad.mit.edu	37	2	219252294	219252294	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:219252294G>T	uc002vhv.2	+	7	918	c.578G>T	c.(577-579)CGG>CTG	p.R193L	SLC11A1_uc010fvp.1_Missense_Mutation_p.R193L|SLC11A1_uc010fvq.1_Missense_Mutation_p.R126L|SLC11A1_uc010zkc.1_Missense_Mutation_p.R126L|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.2_Missense_Mutation_p.R75L|SLC11A1_uc010fvr.2_5'UTR	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	193	Cytoplasmic (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTAGGGCTGCGGAAGCTGGAA	0.393			NA											54	449					3.40343e-31	6.32288e-31	0.01441	1	0
SLC4A3	6508	broad.mit.edu	37	2	220498124	220498124	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:220498124C>T	uc002vmp.3	+	10	1675	c.1406C>T	c.(1405-1407)GCT>GTT	p.A469V	SLC4A3_uc002vmo.3_Missense_Mutation_p.A496V|SLC4A3_uc010fwm.2_Silent_p.L11L|SLC4A3_uc010fwn.1_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	469	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTACCATGGCTGATGACCTG	0.617			NA											8	52					0	0	0.00308	0	0
TM4SF20	79853	broad.mit.edu	37	2	228235652	228235652	+	Silent	SNP	C	C	A	rs138547735	byFrequency	TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:228235652C>A	uc002vpb.2	-	2	266	c.228G>T	c.(226-228)GCG>GCT	p.A76A		NM_024795	NP_079071	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	76	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		TGTTGCAGCACGCTCTTTTTC	0.428			NA											86	318					1.2711e-46	2.5112e-46	0.01441	1	0
UGT1A6	54578	broad.mit.edu	37	2	234602162	234602162	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:234602162T>A	uc002vuv.3	+	1	651	c.512T>A	c.(511-513)TTC>TAC	p.F171Y	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.F171Y	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	171					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		GTGTACCTCTTCAGGGGTTTT	0.498			NA											44	128					0	0	0.01441	0	0
HDAC4	9759	broad.mit.edu	37	2	240011772	240011772	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:240011772C>A	uc002vyk.3	-	18	3098	c.2306G>T	c.(2305-2307)GGG>GTG	p.G769V	HDAC4_uc010fyz.1_Missense_Mutation_p.G764V|HDAC4_uc010fyy.2_Missense_Mutation_p.G726V	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	769	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GCGGGCTGCCCCCGCCGAGTG	0.647			NA											9	44					2.74318e-10	3.61885e-10	0.006214	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3684006	3684006	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr20:3684006G>A	uc002wja.2	-	5	1066	c.1066C>T	c.(1066-1068)CTC>TTC	p.L356F	SIGLEC1_uc002wiz.3_Missense_Mutation_p.L356F|SIGLEC1_uc002wjc.2_Missense_Mutation_p.L267F	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	356	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CTGTAGCGGAGATCACTGGGT	0.577			NA											12	40					0	0	0.010729	0	0
CENPB	1059	broad.mit.edu	37	20	3766048	3766048	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr20:3766048G>A	uc002wjk.2	-	1	1290	c.1083C>T	c.(1081-1083)CTC>CTT	p.L361L	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	361					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						GGGCCTCCGTGAGACCCAGCT	0.662			NA											3	8					0	0	0.004672	0	0
BTBD3	22903	broad.mit.edu	37	20	11904038	11904038	+	Missense_Mutation	SNP	G	G	T	rs150807132		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr20:11904038G>T	uc002wnz.2	+	4	1652	c.1293G>T	c.(1291-1293)CAG>CAT	p.Q431H	BTBD3_uc002wny.2_Missense_Mutation_p.Q370H|BTBD3_uc002woa.2_Missense_Mutation_p.Q370H|BTBD3_uc010zrf.1_Missense_Mutation_p.Q280H|BTBD3_uc010zrg.1_Missense_Mutation_p.Q280H|BTBD3_uc010zrh.1_Missense_Mutation_p.Q280H	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	431										ovary(2)|central_nervous_system(1)	3						TTAAGCGGCAGGGCGTTGTCC	0.493			NA											31	26					3.80469e-20	6.23847e-20	0.009535	1	0
DEFB116	245930	broad.mit.edu	37	20	29891154	29891154	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr20:29891154T>A	uc010ztm.1	-	2	170	c.170A>T	c.(169-171)CAA>CTA	p.Q57L		NM_001037731	NP_001032820	Q30KQ4	DB116_HUMAN	beta-defensin 116 precursor	57					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGTTAAGTATTGGATTTCATA	0.443			NA											161	164					0	0	0.01441	0	0
ZNF831	128611	broad.mit.edu	37	20	57767000	57767000	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr20:57767000C>T	uc002yan.2	+	1	926	c.926C>T	c.(925-927)GCC>GTC	p.A309V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	309						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCGCCGACCGCCGGGAAGCCG	0.701			NA											19	21					0	0	0.007413	0	0
TPTE	7179	broad.mit.edu	37	21	10934106	10934106	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:10934106C>A	uc002yip.1	-	16	1239	c.871G>T	c.(871-873)GAT>TAT	p.D291Y	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D273Y|TPTE_uc002yir.1_Missense_Mutation_p.D253Y|TPTE_uc010gkv.1_Missense_Mutation_p.D153Y	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	291	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.V291I(1)		ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCTTAGGATCGTAAGCTCTT	0.308			NA											40	80					7.63091e-17	1.1751e-16	0.007835	1	0
MORC3	23515	broad.mit.edu	37	21	37711173	37711173	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:37711173A>G	uc002yvi.2	+	5	638	c.562A>G	c.(562-564)ATT>GTT	p.I188V		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	188					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ACTTGATGCTATTATAGGCAA	0.428			NA											109	200					0	0	0.01441	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086924	39086924	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:39086924G>T	uc011aej.1	-	3	589	c.536C>A	c.(535-537)TCC>TAC	p.S179Y	KCNJ6_uc002ywo.2_Missense_Mutation_p.S179Y	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	179	Helical; Name=M2; (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	ATTGACAATGGACCCCAACAC	0.453	Pancreas(48;379 1118 2936 19024 28214)		NA											42	91					1.05386e-31	1.97598e-31	0.01441	1	0
UMODL1	89766	broad.mit.edu	37	21	43557548	43557548	+	Splice_Site	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:43557548G>T	uc002zaf.1	+	22	3776	c.3776_splice	c.e22-1	p.G1259_splice	UMODL1_uc002zad.1_Splice_Site_p.G1187_splice|UMODL1_uc002zae.1_Splice_Site_p.G1315_splice|UMODL1_uc002zag.1_Splice_Site_p.G1387_splice|UMODL1_uc002zal.1_Splice_Site_p.G209_splice|UMODL1_uc010gpa.1_Splice_Site	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TCCTCCCCGAGGTGAGCCTCC	0.597	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											66	123					2.10328e-26	3.71978e-26	0.01441	1	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											31	55					0	0	0.010818	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45970944	45970944	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr21:45970944G>C	uc002zfi.1	-	1	445	c.398C>G	c.(397-399)TCT>TGT	p.S133C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	133	22 X 5 AA repeats of C-C-X(3).|11.					keratin filament				large_intestine(1)	1						GCAGGAGGAAGAGGCACAGCA	0.617			NA											4	113					0	0	0.009096	0	0
POTEH	23784	broad.mit.edu	37	22	16279254	16279254	+	Silent	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr22:16279254T>C	uc010gqp.2	-	4	1021	c.969A>G	c.(967-969)CAA>CAG	p.Q323Q	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.Q42Q|POTEH_uc002zlj.1_Silent_p.Q158Q	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	323	ANK 5.									skin(1)	1						ATTTCACCACTTGCTGTTTTT	0.323			NA											40	445					0	0	0.01441	0	0
C22orf28	51493	broad.mit.edu	37	22	32792123	32792123	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr22:32792123T>G	uc003amm.2	-	8	1059	c.928A>C	c.(928-930)ATG>CTG	p.M310L	C22orf28_uc011ama.1_RNA	NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	310					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						GCAGCTGCCATTCCCTTCAGA	0.493			NA											63	288					0	0	0.01441	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43195156	43195156	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr22:43195156G>C	uc003bdd.2	-	15	1642	c.1422C>G	c.(1420-1422)AGC>AGG	p.S474R	ARFGAP3_uc010gzf.2_Missense_Mutation_p.S430R	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	474					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						CACTGGACAGGCTGTAGTTCC	0.577	GBM(58;544 1030 21460 27159 48838)		NA											11	19					0	0	0.013537	0	0
KCNH8	131096	broad.mit.edu	37	3	19554470	19554470	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:19554470C>T	uc003cbk.1	+	13	2283	c.2088C>T	c.(2086-2088)CCC>CCT	p.P696P	KCNH8_uc010hex.1_Silent_p.P157P	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	696	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AGTCAGAGCCCAAGGGAAATG	0.333	NSCLC(124;1625 1765 8018 24930 42026)		NA											8	51					0	0	0.006214	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706480	21706480	+	Silent	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:21706480A>T	uc003cce.2	-	2	471	c.63T>A	c.(61-63)CGT>CGA	p.R21R	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	21						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGGCTGGTGGACGGACAAGGG	0.517			NA											17	32					0	0	0.006122	0	0
ARPP21	10777	broad.mit.edu	37	3	35778767	35778767	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:35778767G>T	uc003cgb.2	+	16	1821	c.1557G>T	c.(1555-1557)CAG>CAT	p.Q519H	ARPP21_uc003cga.2_Missense_Mutation_p.Q465H|ARPP21_uc011axy.1_Missense_Mutation_p.Q485H|ARPP21_uc003cgf.2_Missense_Mutation_p.Q320H|ARPP21_uc003cgg.2_Missense_Mutation_p.Q7H	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	519	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGTCCCAACAGCAGCCACCAC	0.647			NA											27	32					9.86323e-18	1.5789e-17	0.003954	1	0
SCN10A	6336	broad.mit.edu	37	3	38781172	38781172	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:38781172G>T	uc003ciq.2	-	14	2114	c.2114C>A	c.(2113-2115)ACC>AAC	p.T705N		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	705	Helical; Name=S2 of repeat II; (Potential).|II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AAAAAATATGGTAAAGACCTA	0.383			NA											14	39					6.81908e-15	1.00793e-14	0.00245	1	0
TGM4	7047	broad.mit.edu	37	3	44952602	44952603	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:44952602_44952603CC>AA	uc003coc.3	+	12	1832_1833	c.1759_1760CC>AA	c.(1759-1761)CCT>AAT	p.P587N		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	587					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTTCCAGTACCCTGAGTTCTCT	0.49			NA											26	52					0	0	0.004672	0	0
UBA7	7318	broad.mit.edu	37	3	49848422	49848422	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:49848422C>A	uc003cxr.2	-	10	1396	c.1225G>T	c.(1225-1227)GCC>TCC	p.A409S		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	409	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CTCACCAGGGCACAGTCCTCA	0.537			NA											10	24					0.00136819	0.00143183	0.013537	1	0
ERC2	26059	broad.mit.edu	37	3	55922538	55922538	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:55922538C>A	uc003dhr.1	-	14	2699	c.2443G>T	c.(2443-2445)GAA>TAA	p.E815*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.E294*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	815	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GCATCCAGTTCCTGTCTGGTC	0.512			NA											79	151					2.84431e-33	5.35788e-33	0.01441	1	0
PROK2	60675	broad.mit.edu	37	3	71830726	71830726	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:71830726G>T	uc003dpa.3	-	2	268	c.114C>A	c.(112-114)TCC>TCA	p.S38S	PROK2_uc003doz.3_Silent_p.S38S	NM_001126128	NP_001119600	Q9HC23	PROK2_HUMAN	prokineticin 2 isoform a precursor	38					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding				0		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		CACCACATTGGGAGTCCTTGT	0.443			NA											17	54					3.32936e-07	3.95422e-07	0.006122	1	0
GABRR3	200959	broad.mit.edu	37	3	97731232	97731232	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:97731232G>A	uc011bgr.1	-	4	486	c.486C>T	c.(484-486)ATC>ATT	p.I162I		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	162	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						CGCGCAGCATGATATTCTCCA	0.453			NA											9	22					0	0	0.006214	0	0
GPR15	2838	broad.mit.edu	37	3	98251936	98251936	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:98251936G>T	uc011bgy.1	+	1	1059	c.1059G>T	c.(1057-1059)AGG>AGT	p.R353S		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	353	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TTGCCAGGAGGAGGAAGAGGT	0.438			NA											12	56					6.40141e-05	6.96928e-05	0.010729	1	0
MYH15	22989	broad.mit.edu	37	3	108110731	108110731	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:108110731G>A	uc003dxa.1	-	38	5423	c.5366C>T	c.(5365-5367)GCC>GTC	p.A1789V		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1789	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTCCAAGTGGGCAATGGTGTC	0.443			NA											16	168					0	0	0.00499	0	0
CPNE4	131034	broad.mit.edu	37	3	131254166	131254166	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:131254166G>A	uc003eok.2	-	16	1982	c.1547C>T	c.(1546-1548)CCA>CTA	p.P516L	CPNE4_uc011blq.1_Missense_Mutation_p.P534L|CPNE4_uc003eol.2_Missense_Mutation_p.P534L|CPNE4_uc003eom.2_Missense_Mutation_p.P516L|CPNE4_uc003eoj.2_Missense_Mutation_p.P67L	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	516										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CAGGGCAGCTGGAGATGCCTG	0.453			NA											17	45					0	0	0.00499	0	0
KY	339855	broad.mit.edu	37	3	134323159	134323159	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:134323159G>C	uc010hty.2	-	11	1310	c.1248C>G	c.(1246-1248)ATC>ATG	p.I416M	KY_uc011blw.1_3'UTR|KY_uc011blx.1_Missense_Mutation_p.I395M	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	416						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						CCTTGGCAAAGATCTGCAGCT	0.537			NA											21	48					0	0	0.00278	0	0
CP	1356	broad.mit.edu	37	3	148927062	148927062	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:148927062G>T	uc003ewy.3	-	4	970	c.717C>A	c.(715-717)TAC>TAA	p.Y239*	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Nonsense_Mutation_p.Y20*|CP_uc003ewz.2_Nonsense_Mutation_p.Y239*|CP_uc010hvf.1_5'Flank	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	239	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	GTTCTGAGCAGTAGGTTTTAA	0.348			NA											18	64					5.01169e-05	5.51559e-05	0.00499	1	0
SLITRK3	22865	broad.mit.edu	37	3	164907671	164907671	+	Silent	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:164907671A>T	uc003fej.3	-	2	1392	c.948T>A	c.(946-948)TCT>TCA	p.S316S	SLITRK3_uc003fek.2_Silent_p.S316S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	316	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TAAAATGAACAGAGGATAGCA	0.473			NA								HNSCC(40;0.11)			50	108					0	0	0.01441	0	0
ZBBX	79740	broad.mit.edu	37	3	167016239	167016239	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:167016239T>A	uc003fep.2	-	18	2056	c.1733A>T	c.(1732-1734)CAA>CTA	p.Q578L	ZBBX_uc011bpc.1_Missense_Mutation_p.Q578L|ZBBX_uc003feq.2_Missense_Mutation_p.Q549L	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	578						intracellular	zinc ion binding	p.Q578fs*0(1)		ovary(2)	2						GGCTATTTCTTGTAACAACTA	0.284			NA											6	76					0	0	0.001168	0	0
LRRC31	79782	broad.mit.edu	37	3	169574170	169574170	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:169574170C>T	uc003fgc.1	-	5	854	c.777G>A	c.(775-777)CTG>CTA	p.L259L	LRRC31_uc010hwp.1_Silent_p.L203L	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	259	LRR 2.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			AATGTAACTTCAGTACTTTCA	0.323			NA											20	97					0	0	0.012319	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186570891	186570891	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:186570891G>T	uc003fra.2	+	2	128	c.44G>T	c.(43-45)GGT>GTT	p.G15V	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G15V	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	15					brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GCTCTGCCCGGTCATGACCAG	0.617			NA											24	46					8.24728e-16	1.24169e-15	0.004656	1	0
ATP13A5	344905	broad.mit.edu	37	3	193039469	193039469	+	Splice_Site	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:193039469C>G	uc011bsq.1	-	16	1915	c.1915_splice	c.e16+1	p.V639_splice		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AGTGTTAGTACCTGTTTCAGA	0.303			NA											4	84					0	0	0.000602	0	0
TECRL	253017	broad.mit.edu	37	4	65170927	65170927	+	Silent	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:65170927A>G	uc003hcv.2	-	7	796	c.687T>C	c.(685-687)TCT>TCC	p.S229S	TECRL_uc003hcw.2_Silent_p.S229S	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	229	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AGGCAATCCAAGAAGTAAATC	0.299			NA											25	61					0	0	0.004656	0	0
UGT2B15	7366	broad.mit.edu	37	4	69513061	69513061	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:69513061C>A	uc011cal.1	-	6	1392	c.1354G>T	c.(1354-1356)GAC>TAC	p.D452Y		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	452					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						ATTGGTTGGTCATGATGAATT	0.388			NA											31	86					3.62531e-18	5.8496e-18	0.004289	1	0
UGT2B4	7363	broad.mit.edu	37	4	70361499	70361499	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:70361499C>A	uc003hek.3	-	1	128	c.81G>T	c.(79-81)CTG>CTT	p.L27L	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Silent_p.L27L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	27					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TGGGCCACACCAGCACCTTTC	0.458			NA											40	106					2.5098e-30	4.62032e-30	0.004878	1	0
G3BP2	9908	broad.mit.edu	37	4	76582913	76582913	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:76582913T>C	uc003hir.2	-	4	344	c.179A>G	c.(178-180)GAT>GGT	p.D60G	G3BP2_uc003his.2_Missense_Mutation_p.D60G|G3BP2_uc003hit.2_Missense_Mutation_p.D60G	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	60	NTF2.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GTGGTGTATATCCTTTATTAG	0.373			NA											46	89					0	0	0.010771	0	0
USO1	8615	broad.mit.edu	37	4	76726398	76726398	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:76726398G>T	uc003hiu.2	+	18	2406	c.2231G>T	c.(2230-2232)CGT>CTT	p.R744L	USO1_uc003hiv.2_Missense_Mutation_p.R586L|USO1_uc003hiw.2_Missense_Mutation_p.R579L	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	744	Potential.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GAATTAAAACGTAATCAGGAA	0.363			NA											14	13					9.31168e-06	1.06532e-05	0.001855	1	0
MEPE	56955	broad.mit.edu	37	4	88767549	88767549	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:88767549G>T	uc003hqy.2	+	4	1568	c.1529G>T	c.(1528-1530)AGT>ATT	p.S510I	MEPE_uc010ikn.2_Missense_Mutation_p.S397I	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	510					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGGGATGACAGTAGTGAGTCA	0.517			NA											49	123					9.59835e-30	1.75105e-29	0.01441	1	0
UNC5C	8633	broad.mit.edu	37	4	96091427	96091427	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:96091427G>T	uc003htp.1	-	15	2662	c.2508C>A	c.(2506-2508)GTC>GTA	p.V836V	uc003hto.2_5'Flank	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	836	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGGGCCCCGTGACCGTGGTGA	0.577			NA											58	144					2.2129e-31	4.13006e-31	0.01441	1	0
ANK2	287	broad.mit.edu	37	4	114275528	114275528	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:114275528C>A	uc003ibe.3	+	38	5854	c.5754C>A	c.(5752-5754)CCC>CCA	p.P1918P	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.P1933P	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1885	Repeat-rich region.|Repeat A.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGTATCGCCCTCCGGGAGGA	0.507			NA											17	22					3.45872e-05	3.86956e-05	0.004007	1	0
FAT4	79633	broad.mit.edu	37	4	126372736	126372736	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:126372736G>T	uc003ifj.3	+	9	10565	c.10565G>T	c.(10564-10566)CGG>CTG	p.R3522L	FAT4_uc011cgp.1_Missense_Mutation_p.R1820L|FAT4_uc003ifi.1_Missense_Mutation_p.R1000L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3522	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAAAACAAACGGCCAGGCACT	0.488			NA											37	70					2.75727e-19	4.48472e-19	0.004878	1	0
INPP4B	8821	broad.mit.edu	37	4	143045795	143045795	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:143045795G>T	uc003iix.3	-	20	2434	c.1839C>A	c.(1837-1839)AGC>AGA	p.S613R	INPP4B_uc003iiw.3_Missense_Mutation_p.S613R|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.S428R|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.S484R	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	613					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					ACTGGGGCAAGCTGTACGCAA	0.498			NA											20	24					0.000132079	0.000143027	0.008871	1	0
MAB21L2	10586	broad.mit.edu	37	4	151504265	151504265	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:151504265C>A	uc003ilw.2	+	1	1189	c.84C>A	c.(82-84)GCC>GCA	p.A28A	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	28					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		CGGCCATCGCCAAAACCATCC	0.592			NA											5	18					0.000602214	0.000636806	0.000602	1	0
VEGFC	7424	broad.mit.edu	37	4	177632762	177632762	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:177632762C>A	uc003ius.1	-	4	1025	c.595G>T	c.(595-597)GTA>TTA	p.V199L		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	199					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTGATTGTTACTGGTTTGGGG	0.383			NA											39	74					2.59497e-14	3.82168e-14	0.007835	1	0
SORBS2	8470	broad.mit.edu	37	4	186544384	186544384	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:186544384C>A	uc003iyl.2	-	13	3045	c.2187G>T	c.(2185-2187)GAG>GAT	p.E729D	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.E829D|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.E633D|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.E843D|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	729						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGTCCAGAGCCTCAAACACAG	0.458	Esophageal Squamous(153;41 2433 9491 36028)		NA											72	221					4.66136e-34	8.82174e-34	0.01441	1	0
F11	2160	broad.mit.edu	37	4	187197457	187197457	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:187197457C>A	uc003iza.1	+	7	1001	c.668C>A	c.(667-669)GCT>GAT	p.A223D		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	223	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GCTCCCGATGCTTTTGTCTGT	0.473			NA											18	50					1.15919e-05	1.31137e-05	0.008871	1	0
TRIML1	339976	broad.mit.edu	37	4	189068134	189068134	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr4:189068134G>T	uc003izm.1	+	6	1130	c.1015G>T	c.(1015-1017)GGG>TGG	p.G339W	TRIML1_uc003izn.1_Missense_Mutation_p.G63W	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	339	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTTCACCAGTGGGAGACACTA	0.552	Melanoma(31;213 1036 16579 23968 32372)		NA											23	47					5.26018e-13	7.50131e-13	0.012319	1	0
FASTKD3	79072	broad.mit.edu	37	5	7866830	7866830	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:7866830G>A	uc003jeb.2	-	2	1504	c.1367C>T	c.(1366-1368)TCA>TTA	p.S456L	FASTKD3_uc011cmp.1_Missense_Mutation_p.S158L|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	456					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TTCATTAAGTGAACATGAATG	0.368			NA											13	182					0	0	0.013537	0	0
CTNND2	1501	broad.mit.edu	37	5	11364842	11364842	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:11364842C>T	uc003jfa.1	-	8	1483	c.1338G>A	c.(1336-1338)CCG>CCA	p.P446P	CTNND2_uc010itt.2_Silent_p.P355P|CTNND2_uc011cmy.1_Silent_p.P109P|CTNND2_uc011cmz.1_Silent_p.P13P|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.P13P	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	446					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGTGTGCTGGCGGCAGAGGGT	0.617			NA											4	43					0	0	0.001168	0	0
IL7R	3575	broad.mit.edu	37	5	35876392	35876392	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:35876392A>T	uc003jjs.2	+	8	1273	c.1184A>T	c.(1183-1185)AAG>ATG	p.K395M	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	395	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGAGTGGCAAGAATGGGCCT	0.542			NA											6	75					0	0	0.001984	0	0
C9	735	broad.mit.edu	37	5	39306769	39306769	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:39306769C>T	uc003jlv.3	-	9	1455	c.1366G>A	c.(1366-1368)GTC>ATC	p.V456I		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	456	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GCCCAGTTGACAAAGTCAGTC	0.363			NA											26	107					0	0	0.008361	0	0
PTGER4	5734	broad.mit.edu	37	5	40681206	40681206	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:40681206G>T	uc003jlz.2	+	2	703	c.111G>T	c.(109-111)GTG>GTT	p.V37V		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	37	Helical; Name=1; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						GCAACCTGGTGGCCATCGTGG	0.622			NA									OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	115					2.23348e-06	2.59931e-06	0.004007	1	0
ELOVL7	79993	broad.mit.edu	37	5	60067911	60067911	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:60067911A>T	uc003jsi.3	-	4	274	c.74T>A	c.(73-75)GTT>GAT	p.V25D	ELOVL7_uc011cqo.1_Translation_Start_Site|ELOVL7_uc010iwk.2_Missense_Mutation_p.V25D|ELOVL7_uc003jsj.3_Missense_Mutation_p.V12D	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	25					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				CCAATCTTCAACTCTTGGATC	0.438			NA											6	22					0	0	0.00308	0	0
CD180	4064	broad.mit.edu	37	5	66492422	66492422	+	Silent	SNP	G	G	T	rs146337741		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:66492422G>T	uc003juy.2	-	1	196	c.48C>A	c.(46-48)GCC>GCA	p.A16A		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	16					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CTTTACAGCCGGCAGAAAACA	0.448			NA											108	59					1.37938e-74	2.76558e-74	0.01441	1	0
CENPH	64946	broad.mit.edu	37	5	68491566	68491566	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:68491566G>C	uc003jvp.2	+	4	349	c.262G>C	c.(262-264)GAA>CAA	p.E88Q	CENPH_uc010ixc.2_Missense_Mutation_p.E88Q	NM_022909	NP_075060	Q9H3R5	CENPH_HUMAN	centromere protein H	88	Potential.				cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			large_intestine(1)	1		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		CCTGGAAAATGAAATTGAAGA	0.274			NA											14	18					0	0	0.004007	0	0
IQGAP2	10788	broad.mit.edu	37	5	75950817	75950817	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:75950817A>G	uc003kek.2	+	20	2531	c.2309A>G	c.(2308-2310)TAC>TGC	p.Y770C	IQGAP2_uc010izv.2_Missense_Mutation_p.Y323C|IQGAP2_uc011csv.1_Missense_Mutation_p.Y266C|IQGAP2_uc003kel.2_Missense_Mutation_p.Y266C	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	770	IQ 3.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGAGATGACTACAAAACATTG	0.393			NA											47	22					0	0	0.01441	0	0
TTC37	9652	broad.mit.edu	37	5	94876421	94876421	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:94876421C>G	uc003klb.2	-	8	786	c.516G>C	c.(514-516)GAG>GAC	p.E172D	TTC37_uc010jbf.1_Missense_Mutation_p.E124D	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	172							binding			ovary(3)|pancreas(1)	4						TATTCTGGTCCTCTGTACTTT	0.353			NA											33	37					0	0	0.013726	0	0
MCC	4163	broad.mit.edu	37	5	112720711	112720711	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:112720711C>A	uc003kql.3	-	2	785	c.369G>T	c.(367-369)CTG>CTT	p.L123L	MCC_uc003kqk.3_RNA	NM_001085377	NP_001078846	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 1	Error:Variant_position_missing_in_P23508_after_alignment					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TTCTATCCCTCAGCTTCTTTG	0.478			NA											33	28					4.74835e-14	6.94254e-14	0.010818	1	0
COMMD10	51397	broad.mit.edu	37	5	115469791	115469791	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:115469791C>A	uc003krt.1	+	5	449	c.426C>A	c.(424-426)AAC>AAA	p.N142K		NM_016144	NP_057228	Q9Y6G5	COMDA_HUMAN	COMM domain containing 10	142	COMM.						protein binding			ovary(1)	1		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)		GGCAGCTTAACCTTCAGATGG	0.413			NA											7	18					5.18039e-06	5.99445e-06	0.00308	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128994400	128994400	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:128994400A>T	uc003kvb.1	+	15	2377	c.2377A>T	c.(2377-2379)AAA>TAA	p.K793*	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	793	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAAGATCATTAAAGGGGATTT	0.343			NA											40	74					0	0	0.00623	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711144	140711144	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:140711144C>G	uc003lji.1	+	1	893	c.893C>G	c.(892-894)ACA>AGA	p.T298R	PCDHGA1_uc011dan.1_Missense_Mutation_p.T298R	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	298	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTCTTACACAGGAGAAATA	0.423			NA											4	47					0	0	0.009096	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720142	140720142	+	Missense_Mutation	SNP	G	G	T	rs116787237	byFrequency	TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:140720142G>T	uc003ljk.1	+	1	1789	c.1604G>T	c.(1603-1605)CGG>CTG	p.R535L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.R535L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	535	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGATAGCGCGGGACAGCGGG	0.537			NA											37	48					8.69298e-16	1.30395e-15	0.006999	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140724495	140724495	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:140724495G>A	uc003ljm.1	+	1	895	c.895G>A	c.(895-897)GGA>AGA	p.G299R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.G59R|PCDHGA3_uc011dap.1_Missense_Mutation_p.G299R	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	299	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGTGAGTGGAGAAGTATC	0.388			NA											16	11					0	0	0.004007	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696494	150696494	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:150696494G>T	uc003lty.2	-	10	1466	c.1336C>A	c.(1336-1338)CTG>ATG	p.L446M	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.L248M	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	446	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGCTGATCAGGGCGTCCTTG	0.612			NA											18	9					2.35188e-11	3.19635e-11	0.006122	1	0
ITK	3702	broad.mit.edu	37	5	156668716	156668716	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:156668716C>A	uc003lwo.1	+	11	1128	c.1046C>A	c.(1045-1047)GCA>GAA	p.A349E		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	349					cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.A349S(1)		lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGTTACAGCAGGGCTGAGA	0.498	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								18	14					6.94344e-10	8.89903e-10	0.006122	1	0
STK10	6793	broad.mit.edu	37	5	171533719	171533719	+	Silent	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr5:171533719G>C	uc003mbo.1	-	6	993	c.693C>G	c.(691-693)GCC>GCG	p.A231A		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	231	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTCGATCTGGGCCATCTCAA	0.607			NA									OREG0017039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	38					0	0	0.006214	0	0
C6orf114	85411	broad.mit.edu	37	6	13470384	13470384	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:13470384G>C	uc003nav.2	-	2	652	c.129C>G	c.(127-129)ATC>ATG	p.I43M	GFOD1_uc003nas.1_Intron|GFOD1_uc003nat.1_Intron|C6orf114_uc003nau.2_RNA	NM_033069	NP_149060			hypothetical protein LOC85411												0	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0504)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.147)			TGTAGCCAGTGATGTCCCACT	0.448			NA											15	40					0	0	0.00499	0	0
DHX16	8449	broad.mit.edu	37	6	30633333	30633333	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:30633333C>A	uc003nqz.2	-	5	1056	c.844G>T	c.(844-846)GAG>TAG	p.E282*	DHX16_uc011dmo.1_Nonsense_Mutation_p.E222*	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	282					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						GCCCGGTACTCCCGGGCGAGA	0.627			NA											32	41					2.46105e-21	4.10175e-21	0.010818	1	0
VARS	7407	broad.mit.edu	37	6	31749539	31749539	+	Splice_Site	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:31749539C>A	uc003nxe.2	-	20	2771	c.2348_splice	c.e20-1	p.D783_splice	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_Intron	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase						translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	ACATCCTCATCTGAGAGAGGC	0.602			NA											39	69					1.30998e-17	2.08056e-17	0.005524	1	0
DNAH8	1769	broad.mit.edu	37	6	38891908	38891908	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:38891908T>G	uc003ooe.1	+	71	10881	c.10281T>G	c.(10279-10281)AAT>AAG	p.N3427K	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAAACCTGAATCTTATTTCAA	0.343			NA											30	70					0	0	0.008361	0	0
DAAM2	23500	broad.mit.edu	37	6	39835296	39835296	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:39835296C>T	uc003oow.2	+	6	595	c.439C>T	c.(439-441)CGC>TGC	p.R147C	DAAM2_uc010jxc.2_Missense_Mutation_p.R147C|DAAM2_uc003oox.2_Missense_Mutation_p.R147C	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	147	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					GTTTGTGACCCGCTTCATTGA	0.478			NA											5	112					0	0	0.000602	0	0
TRERF1	55809	broad.mit.edu	37	6	42236542	42236542	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:42236542G>T	uc003osd.2	-	5	1350	c.787C>A	c.(787-789)CAG>AAG	p.Q263K	TRERF1_uc011duq.1_Missense_Mutation_p.Q263K|TRERF1_uc003osb.2_Missense_Mutation_p.Q102K|TRERF1_uc003osc.2_Missense_Mutation_p.Q102K|TRERF1_uc003ose.2_Missense_Mutation_p.Q263K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	263	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGCTGCATCTGTTGCATGTGC	0.567			NA											23	100					1.22574e-08	1.51812e-08	0.014323	1	0
CRIP3	401262	broad.mit.edu	37	6	43276112	43276112	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:43276112G>C	uc010jyn.1	-	2	79	c.79C>G	c.(79-81)CGC>GGC	p.R27G	CRIP3_uc003ouu.1_Missense_Mutation_p.R27G	NM_206922	NP_996805	Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3	27	LIM zinc-binding 1.					cytoplasm	zinc ion binding			skin(1)	1			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			AGGCAGAAGCGGTGCCAGTTC	0.607			NA											5	49					0	0	0.000602	0	0
MEP1A	4224	broad.mit.edu	37	6	46806780	46806780	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:46806780C>A	uc010jzh.1	+	14	2190	c.2148C>A	c.(2146-2148)GGC>GGA	p.G716G	MEP1A_uc011dwg.1_Silent_p.G438G|MEP1A_uc011dwh.1_Silent_p.G744G|MEP1A_uc011dwi.1_Silent_p.G616G	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	716	Helical; (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			AGGTGCACGGCAGTGTCCTGG	0.577			NA											27	140					1.75199e-13	2.50726e-13	0.007291	1	0
PGK2	5232	broad.mit.edu	37	6	49754615	49754615	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:49754615G>A	uc003ozu.2	-	1	393	c.286C>T	c.(286-288)CTG>TTG	p.L96L		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	96					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					CAGTCCTTCAGGAACAGAACA	0.522			NA											45	66					0	0	0.013114	0	0
EYS	346007	broad.mit.edu	37	6	66205157	66205157	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:66205157G>T	uc011dxu.1	-	4	685	c.147C>A	c.(145-147)ATC>ATA	p.I49I	EYS_uc003peq.2_Silent_p.I49I|EYS_uc003per.1_Silent_p.I49I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	49					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AGTCCAAGCAGATGTTTTCTG	0.403			NA											23	126					3.5997e-14	5.28217e-14	0.014323	1	0
GJA10	84694	broad.mit.edu	37	6	90605636	90605636	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:90605636G>A	uc011eaa.1	+	1	1449	c.1449G>A	c.(1447-1449)CAG>CAA	p.Q483Q		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	483	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TGGTAAGACAGGCAGCCCTAC	0.478			NA											18	52					0	0	0.008871	0	0
FBXL4	26235	broad.mit.edu	37	6	99374630	99374630	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:99374630C>A	uc003ppf.1	-	3	593	c.235G>T	c.(235-237)GCT>TCT	p.A79S	FBXL4_uc003ppg.1_Missense_Mutation_p.A79S|FBXL4_uc003pph.1_5'UTR	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	79					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		GGTACACCAGCCAAATTCCAC	0.438			NA											19	62					1.01871e-10	1.36165e-10	0.008871	1	0
SLC22A16	85413	broad.mit.edu	37	6	110763799	110763799	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:110763799C>A	uc003puf.2	-	4	898	c.831G>T	c.(829-831)GTG>GTT	p.V277V	SLC22A16_uc003pue.2_Silent_p.V258V	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	277	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		AGGGGACAGTCACTGTGGAGA	0.478			NA											11	44					5.50884e-06	6.35635e-06	0.013537	1	0
ENPP3	5169	broad.mit.edu	37	6	132058512	132058512	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:132058512G>T	uc003qcu.3	+	23	2454	c.2107G>T	c.(2107-2109)GAT>TAT	p.D703Y	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.D703Y	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	703	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		TAGAACATCAGATAGCCAATA	0.294			NA											17	67					4.63292e-17	7.16158e-17	0.008871	1	0
TAAR9	134860	broad.mit.edu	37	6	132859760	132859760	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:132859760T>G	uc011eci.1	+	2	334	c.332T>G	c.(331-333)TTT>TGT	p.F111C		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	111	Helical; Name=3; (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		CATACATGTTTTGACACATCC	0.418	Colon(10;433 445 15992 45047 47213)		NA											11	47					0	0	0.013537	0	0
EYA4	2070	broad.mit.edu	37	6	133785997	133785997	+	Splice_Site	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:133785997G>A	uc003qec.3	+	10	1262	c.804_splice	c.e10+1	p.Q268_splice	EYA4_uc011ecq.1_Splice_Site_p.Q214_splice|EYA4_uc011ecr.1_Splice_Site_p.Q214_splice|EYA4_uc003qed.3_Splice_Site_p.Q268_splice|EYA4_uc003qee.3_Splice_Site_p.Q245_splice|EYA4_uc011ecs.1_Splice_Site_p.Q268_splice|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a						anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TTCACAACAGGTATAGTAGCT	0.323	Melanoma(57;398 1237 3528 4702 7415)		NA											6	22					0	0	0.001168	0	0
ELMO1	9844	broad.mit.edu	37	7	36927225	36927225	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:36927225G>T	uc003tfk.1	-	18	1961	c.1654C>A	c.(1654-1656)CGC>AGC	p.R552S	ELMO1_uc003tfi.1_Missense_Mutation_p.R72S|ELMO1_uc003tfj.1_Missense_Mutation_p.R72S|ELMO1_uc011kbb.1_Intron|ELMO1_uc011kbc.1_Missense_Mutation_p.R456S|ELMO1_uc010kxg.1_Missense_Mutation_p.R552S	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	552					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						CGGTTCAGGCGTTGCTGTTTG	0.473			NA											34	66					2.40579e-17	3.76998e-17	0.00623	1	0
ELMO1	9844	broad.mit.edu	37	7	37252959	37252959	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:37252959T>G	uc003tfk.1	-	12	1242	c.935A>C	c.(934-936)AAA>ACA	p.K312T	ELMO1_uc011kbc.1_Missense_Mutation_p.K216T|ELMO1_uc010kxg.1_Missense_Mutation_p.K312T	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	312					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GGGGTCCATTTTGGTCATCAT	0.498			NA											5	146					0	0	0.000602	0	0
ABCA13	154664	broad.mit.edu	37	7	48320968	48320968	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:48320968C>T	uc003toq.2	+	19	8780	c.8755C>T	c.(8755-8757)CAG>TAG	p.Q2919*	ABCA13_uc010kys.1_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2919					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGTTTTCCAGCAGACTGTGAA	0.428			NA											3	12					0	0	0.009096	0	0
ABCA13	154664	broad.mit.edu	37	7	48520676	48520676	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:48520676A>G	uc003toq.2	+	46	13044	c.13019A>G	c.(13018-13020)CAC>CGC	p.H4340R	ABCA13_uc010kys.1_Missense_Mutation_p.H1415R|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.H70R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4340					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTGACCAACCACCTGGGCCAC	0.408			NA											4	13					0	0	0.000602	0	0
CDC14C	168448	broad.mit.edu	37	7	48964946	48964946	+	Silent	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:48964946T>C	uc010kyv.1	+	1	790	c.678T>C	c.(676-678)AAT>AAC	p.N226N		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						AGAATCACAATGTTACTACCA	0.403			NA											14	39					0	0	0.00333	0	0
ZPBP	11055	broad.mit.edu	37	7	50129290	50129290	+	Missense_Mutation	SNP	C	C	A	rs148222395		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:50129290C>A	uc003tou.2	-	2	213	c.143G>T	c.(142-144)CGA>CTA	p.R48L	ZPBP_uc010kyw.2_Missense_Mutation_p.R48L	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	48					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TCTTGGTAATCGAACCAAGTG	0.284			NA											7	23					0.00307968	0.00318995	0.00308	1	0
SEC61G	23480	broad.mit.edu	37	7	54825215	54825215	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:54825215T>C	uc003tqf.2	-	2	158	c.67A>G	c.(67-69)AAA>GAA	p.K23E	SEC61G_uc003tqg.2_Missense_Mutation_p.K23E	NM_001012456	NP_001012474	P60059	SC61G_HUMAN	Sec61 gamma subunit	23	Cytoplasmic (Potential).				protein targeting to ER	endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			lung(1)	1	Esophageal squamous(2;7.55e-08)|Breast(14;0.0654)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)			GTGCATCTTTTAACCAGCCGA	0.358			NA											39	90					0	0	0.007835	0	0
ZNF117	51351	broad.mit.edu	37	7	64438693	64438693	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:64438693C>A	uc003ttr.2	-	4	2541	c.1256G>T	c.(1255-1257)TGT>TTT	p.C419F		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	419	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				ACATTCTTCACATTTGTAGAG	0.378			NA											41	25					2.26627e-22	3.85648e-22	0.007835	1	0
PCLO	27445	broad.mit.edu	37	7	82546048	82546048	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:82546048A>T	uc003uhx.2	-	7	11543	c.11254T>A	c.(11254-11256)TGC>AGC	p.C3752S	PCLO_uc003uhv.2_Missense_Mutation_p.C3752S|PCLO_uc010lec.2_Missense_Mutation_p.C717S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3683					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGGTTCTGCAGATCCTTCTC	0.458			NA											7	53					0	0	0.001984	0	0
ABCB4	5244	broad.mit.edu	37	7	87037453	87037453	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:87037453T>G	uc003uiv.1	-	25	3255	c.3179A>C	c.(3178-3180)AAG>ACG	p.K1060T	ABCB4_uc003uiw.1_Missense_Mutation_p.K1060T|ABCB4_uc003uix.1_Missense_Mutation_p.K1013T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1060	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTGGCCTTTCTTCACCTCCAG	0.552			NA											5	89					0	0	0.000602	0	0
TECPR1	25851	broad.mit.edu	37	7	97852397	97852397	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:97852397C>A	uc003upg.2	-	21	3038	c.2833G>T	c.(2833-2835)GGT>TGT	p.G945C		NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	945						integral to membrane	protein binding			pancreas(1)	1						CCCTCGGCACCCGGGCTCTCC	0.672			NA											3	2					0.00024832	0.000266057	0.009096	1	0
FOXP2	93986	broad.mit.edu	37	7	114269998	114269998	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:114269998C>A	uc003vhb.2	+	5	909	c.535C>A	c.(535-537)CAG>AAG	p.Q179K	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.Q204K|FOXP2_uc003vha.2_Missense_Mutation_p.Q87K|FOXP2_uc011kmu.1_Missense_Mutation_p.Q196K|FOXP2_uc011kmv.1_Missense_Mutation_p.Q179K|FOXP2_uc010ljz.1_Missense_Mutation_p.Q87K|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Missense_Mutation_p.Q179K|FOXP2_uc003vgx.2_Missense_Mutation_p.Q179K|FOXP2_uc003vhd.2_Missense_Mutation_p.Q179K|FOXP2_uc003vhc.2_Missense_Mutation_p.Q204K	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						gcagcaacaacagcagcagca	0.159			NA											6	47					4.096e-09	5.10425e-09	0.001168	1	0
ASZ1	136991	broad.mit.edu	37	7	117025861	117025861	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:117025861C>T	uc003vjb.2	-	5	506	c.443G>A	c.(442-444)AGA>AAA	p.R148K	ASZ1_uc011kno.1_Missense_Mutation_p.R148K|ASZ1_uc011knp.1_Intron	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	148	ANK 4.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			GGTCATAAGTCTCCTAAGGAG	0.418			NA											4	42					0	0	0.009096	0	0
WDR91	29062	broad.mit.edu	37	7	134873253	134873253	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:134873253C>A	uc003vsp.2	-	13	1875	c.1813G>T	c.(1813-1815)GGG>TGG	p.G605W	WDR91_uc010lmq.2_Missense_Mutation_p.G194W|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	605	WD 5.									breast(2)|ovary(1)|skin(1)	4						TAGACCTCCCCGTAGTGGGCC	0.512			NA											75	67					1.69331e-39	3.31301e-39	0.01441	1	0
DGKI	9162	broad.mit.edu	37	7	137170135	137170135	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:137170135C>A	uc003vtt.2	-	24	2413	c.2412G>T	c.(2410-2412)CAG>CAT	p.Q804H	DGKI_uc003vtu.2_Missense_Mutation_p.Q504H	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	804					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						AATGAACTCTCTGGGAGCCAG	0.353			NA											10	8					2.80697e-09	3.51958e-09	0.010729	1	0
FAM115A	9747	broad.mit.edu	37	7	143573464	143573464	+	Missense_Mutation	SNP	C	C	T	rs150435300	byFrequency	TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:143573464C>T	uc003wdo.1	-	2	371	c.238G>A	c.(238-240)GCA>ACA	p.A80T	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.A80T	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	80											0	Melanoma(164;0.0903)					CACCCCACTGCGTTCAGGAGA	0.607			NA											25	17					0	0	0.00278	0	0
OR2A12	346525	broad.mit.edu	37	7	143792988	143792988	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:143792988C>T	uc011kty.1	+	1	788	c.788C>T	c.(787-789)TCA>TTA	p.S263L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					GCCCCCAAGTCAAGCCATTCT	0.552			NA											157	127					0	0	0.01441	0	0
OR2A2	442361	broad.mit.edu	37	7	143806748	143806748	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:143806748C>A	uc011ktz.1	+	1	73	c.73C>A	c.(73-75)CTC>ATC	p.L25I		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					ACTGGCGATTCTCCTCTGTGG	0.517			NA											12	106					0.00185496	0.00193623	0.001855	1	0
TEX15	56154	broad.mit.edu	37	8	30701125	30701125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:30701125G>T	uc003xil.2	-	1	5409	c.5409C>A	c.(5407-5409)TGC>TGA	p.C1803*		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1803										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAAAATCAAAGCAATCGGAAC	0.323			NA											9	18					0.00448238	0.00463103	0.004482	1	0
ANK1	286	broad.mit.edu	37	8	41519408	41519408	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:41519408G>A	uc003xok.2	-	41	5614	c.5530C>T	c.(5530-5532)CAG>TAG	p.Q1844*	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Nonsense_Mutation_p.Q998*|ANK1_uc003xoi.2_Nonsense_Mutation_p.Q1844*|ANK1_uc003xoj.2_Nonsense_Mutation_p.Q1844*|ANK1_uc003xol.2_Nonsense_Mutation_p.Q1682*|ANK1_uc003xom.2_Nonsense_Mutation_p.Q1885*|ANK1_uc011lcl.1_Nonsense_Mutation_p.Q119*|ANK1_uc003xod.2_Nonsense_Mutation_p.Q119*|ANK1_uc003xoc.2_Nonsense_Mutation_p.Q119*|ANK1_uc003xof.2_Intron|MIR486_hsa-mir-486|MI0002470_5'Flank	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1844	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCGTGCTCCTGGGCGGCATCG	0.512			NA											30	48					0	0	0.010818	0	0
SNTG1	54212	broad.mit.edu	37	8	51571151	51571151	+	Splice_Site	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:51571151G>T	uc010lxy.1	+	16	1338	c.967_splice	c.e16-1	p.V323_splice	SNTG1_uc003xqs.1_Splice_Site_p.V323_splice|SNTG1_uc010lxz.1_Splice_Site_p.V323_splice|SNTG1_uc011ldl.1_Splice_Site	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATCTTTTAAAGGTGACCACCT	0.303			NA											6	71					2.7689e-08	3.38792e-08	0.001984	1	0
PCMTD1	115294	broad.mit.edu	37	8	52773652	52773652	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:52773652T>A	uc003xqx.3	-	2	401	c.60A>T	c.(58-60)GAA>GAT	p.E20D	PCMTD1_uc003xqw.3_Missense_Mutation_p.E20D|PCMTD1_uc011ldn.1_Intron|PCMTD1_uc010lya.2_Intron|PCMTD1_uc011ldo.1_Missense_Mutation_p.E20D	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	20						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TATACTGAGCTTCTTTTAAAT	0.358			NA											21	53					0	0	0.014323	0	0
CLVS1	157807	broad.mit.edu	37	8	62212596	62212596	+	Silent	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:62212596T>A	uc003xuh.2	+	2	534	c.210T>A	c.(208-210)CGT>CGA	p.R70R	CLVS1_uc003xug.2_Silent_p.R70R|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Silent_p.R70R	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	70					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GATTTTTACGTACAGATGATG	0.473			NA											22	68					0	0	0.014323	0	0
TRPA1	8989	broad.mit.edu	37	8	72969995	72969995	+	Silent	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:72969995A>T	uc003xza.2	-	9	1225	c.1050T>A	c.(1048-1050)ACT>ACA	p.T350T		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	350	Cytoplasmic (Potential).|ANK 9.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ATGCAGAAGCAGTTGCTAATA	0.373			NA											15	52					0	0	0.00499	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776697	77776697	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:77776697C>A	uc003yav.2	+	11	10999	c.10612C>A	c.(10612-10614)CAG>AAG	p.Q3538K		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3534						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGAGCTGAGCCAGAAGCTAGA	0.453			NA								HNSCC(33;0.089)			29	65					2.48779e-11	3.36976e-11	0.005443	1	0
OSR2	116039	broad.mit.edu	37	8	99961384	99961384	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:99961384C>A	uc003yir.2	+	2	739	c.204C>A	c.(202-204)ACC>ACA	p.T68T	OSR2_uc010mbn.2_Silent_p.T68T|OSR2_uc003yiq.2_Silent_p.T68T|OSR2_uc011lgx.1_Silent_p.T189T	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	68					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CCCGCTCCACCATCACGGAGA	0.652			NA											34	29					5.85407e-19	9.48359e-19	0.01441	1	0
CSMD3	114788	broad.mit.edu	37	8	113420594	113420594	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:113420594G>T	uc003ynu.2	-	34	5717	c.5558C>A	c.(5557-5559)ACT>AAT	p.T1853N	CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Missense_Mutation_p.T1813N|CSMD3_uc011lhx.1_Missense_Mutation_p.T1749N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1853	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCAACTGAAGTAAATCGAAT	0.338			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	62					1.21353e-23	2.09141e-23	0.01441	1	0
ZNF572	137209	broad.mit.edu	37	8	125989475	125989475	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:125989475A>T	uc003yrr.2	+	3	1120	c.965A>T	c.(964-966)CAT>CTT	p.H322L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	322	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAGAGAATACATACAGGAGAA	0.403			NA								HNSCC(60;0.17)			21	55					0	0	0.008871	0	0
ADCY8	114	broad.mit.edu	37	8	131792865	131792865	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:131792865G>T	uc003ytd.3	-	18	3783	c.3527C>A	c.(3526-3528)CCC>CAC	p.P1176H	ADCY8_uc010mds.2_Missense_Mutation_p.P1045H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1176	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GAATGGGTTGGGTTGGACTCT	0.517			NA								HNSCC(32;0.087)			58	74					1.54043e-34	2.92899e-34	0.01441	1	0
CYP11B1	1584	broad.mit.edu	37	8	143960556	143960556	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr8:143960556T>G	uc003yxi.2	-	2	294	c.287A>C	c.(286-288)GAC>GCC	p.D96A	CYP11B1_uc003yxh.2_5'Flank|CYP11B1_uc003yxj.2_Missense_Mutation_p.D96A|CYP11B1_uc010mey.2_Missense_Mutation_p.D141A	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	96					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTTCTCCACGTCCTCCGGCAG	0.632			NA							Familial_Hyperaldosteronism_type_I				8	83					0	0	0.004482	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18574147	18574147	+	Silent	SNP	T	T	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:18574147T>C	uc003zne.3	+	4	484	c.357T>C	c.(355-357)TGT>TGC	p.C119C	ADAMTSL1_uc003znb.2_Silent_p.C119C|ADAMTSL1_uc003znc.3_Silent_p.C119C	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	119						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		ACAACCCATGTTCACTCAAGT	0.458			NA											42	94					0	0	0.01441	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325691	79325691	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:79325691G>T	uc010mpk.2	-	8	1623	c.1499C>A	c.(1498-1500)CCC>CAC	p.P500H		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	500					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AGAAGCCATGGGTGCTGGGTC	0.567			NA											20	17					1.00905e-13	1.45432e-13	0.008871	1	0
XPA	7507	broad.mit.edu	37	9	100459595	100459595	+	Translation_Start_Site	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:100459595C>A	uc004axr.3	-	1	97	c.-20G>T	c.(-22--18)TAGGT>TATGT		XPA_uc004axs.3_RNA	NM_000380	NP_000371	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A						nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity			breast(1)	1		Acute lymphoblastic leukemia(62;0.158)				CTCCGAGGACCTAGCTCCCAG	0.731			NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				6	26					1.12685e-05	1.28195e-05	0.004482	1	0
RNF20	56254	broad.mit.edu	37	9	104303258	104303258	+	Splice_Site	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:104303258G>C	uc004bbn.2	+	5	718	c.628_splice	c.e5+1	p.D210_splice		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20						histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AACAGTGGAGGTGAGGCAAGA	0.438			NA											26	28					0	0	0.00333	0	0
ABCA1	19	broad.mit.edu	37	9	107547747	107547747	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:107547747C>A	uc004bcl.2	-	49	6888	c.6575G>T	c.(6574-6576)AGC>ATC	p.S2192I	NIPSNAP3B_uc004bcj.1_Intron	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2192					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGAGAGGATGCTGAATATCCT	0.418			NA											34	37					8.4185e-14	1.22204e-13	0.012213	1	0
SPTAN1	6709	broad.mit.edu	37	9	131345394	131345394	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:131345394G>T	uc004bvl.3	+	15	1958	c.1845G>T	c.(1843-1845)CAG>CAT	p.Q615H	SPTAN1_uc011mbg.1_Missense_Mutation_p.Q615H|SPTAN1_uc011mbh.1_Missense_Mutation_p.Q627H|SPTAN1_uc004bvm.3_Missense_Mutation_p.Q615H|SPTAN1_uc004bvn.3_Missense_Mutation_p.Q615H	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	615	Spectrin 7.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGAAGCATCAGGCTTTTGAGG	0.463	NSCLC(120;833 1744 2558 35612 37579)		NA											5	53					3.59834e-05	3.99267e-05	0.001168	1	0
ABCA2	20	broad.mit.edu	37	9	139910907	139910907	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr9:139910907C>A	uc011mem.1	-	20	3085	c.2937G>T	c.(2935-2937)ATG>ATT	p.M979I	ABCA2_uc011mel.1_Missense_Mutation_p.M980I|ABCA2_uc004ckl.1_Missense_Mutation_p.M910I|ABCA2_uc004ckm.1_Missense_Mutation_p.M1010I|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	979					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCTCCTCCTCCATGCCACGGG	0.642			NA											14	120					0.000219431	0.000235729	0.00245	1	0
XG	7499	broad.mit.edu	37	X	2688630	2688630	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:2688630C>A	uc011mhg.1	+	2	324	c.101C>A	c.(100-102)CCT>CAT	p.P34H	XG_uc010ndb.2_RNA|XG_uc004cqp.2_Missense_Mutation_p.P34H	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	34	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CTTGATGACCCTGGTAAGTGC	0.488			NA											30	76					1.74807e-11	2.38373e-11	0.010818	1	0
MXRA5	25878	broad.mit.edu	37	X	3235859	3235859	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:3235859A>G	uc004crg.3	-	6	6020	c.5863T>C	c.(5863-5865)TCC>CCC	p.S1955P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1955	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGGTAGTGGGAGGCTAGGATT	0.572			NA											12	35					0	0	0.013537	0	0
MXRA5	25878	broad.mit.edu	37	X	3240143	3240143	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:3240143G>T	uc004crg.3	-	5	3740	c.3583C>A	c.(3583-3585)CAA>AAA	p.Q1195K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1195						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTCTCCACTTGACTTGAAATC	0.473			NA											41	59					4.92203e-23	8.41106e-23	0.00623	1	0
FANCB	2187	broad.mit.edu	37	X	14863393	14863393	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:14863393C>A	uc004cwg.1	-	8	1780	c.1512G>T	c.(1510-1512)GTG>GTT	p.V504V	FANCB_uc004cwh.1_Silent_p.V504V	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	504					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					ATGATAAAGTCACATCATTCA	0.348			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				18	57					3.32936e-07	3.95422e-07	0.006122	1	0
MAP3K15	389840	broad.mit.edu	37	X	19389565	19389565	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:19389565G>T	uc004czk.1	-	24	3254	c.1617C>A	c.(1615-1617)CAC>CAA	p.H539Q	MAP3K15_uc004czj.1_Missense_Mutation_p.H499Q|MAP3K15_uc004czi.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	1064							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CCATCACCCGGTGCTCTGGGG	0.502			NA											37	77					2.54651e-27	4.54333e-27	0.006999	1	0
ACOT9	23597	broad.mit.edu	37	X	23723693	23723693	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:23723693G>T	uc004dap.2	-	12	1071	c.925C>A	c.(925-927)CGG>AGG	p.R309R	ACOT9_uc004dan.2_Silent_p.R59R|ACOT9_uc004dao.2_Silent_p.R318R|ACOT9_uc004daq.2_Silent_p.R267R|ACOT9_uc004dar.2_Silent_p.R249R|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Silent_p.R249R	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	309					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						CCAAAGATCCGATTGAAAATG	0.398			NA											46	110					5.34276e-22	9.0159e-22	0.01441	1	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938179	29938179	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:29938179G>C	uc004dby.2	+	8	1533	c.1025G>C	c.(1024-1026)CGT>CCT	p.R342P		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	342	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GGAAATGGACGTCGACACGCC	0.438			NA											28	59					0	0	0.007291	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269550	30269550	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:30269550A>G	uc004dcc.2	+	4	1260	c.940A>G	c.(940-942)AGA>GGA	p.R314G	MAGEB1_uc004dcd.2_Missense_Mutation_p.R314G|MAGEB1_uc004dce.2_Missense_Mutation_p.R314G	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	314											0						TGAGGAAGAGAGAGCCCAAGT	0.537			NA											20	56					0	0	0.012319	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820780	35820780	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:35820780T>A	uc010ngt.1	+	2	746	c.467T>A	c.(466-468)CTG>CAG	p.L156Q		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	156	MAGE.							p.L323R(1)		lung(3)|ovary(2)|breast(1)|skin(1)	7						GAGATCCTCCTGAGAGCTTCT	0.468			NA											16	60					0	0	0.004007	0	0
FAM47C	442444	broad.mit.edu	37	X	37026557	37026557	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:37026557C>T	uc004ddl.1	+	1	88	c.74C>T	c.(73-75)CCG>CTG	p.P25L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	25										ovary(3)	3						TGTGACAAACCGCCTTCCAAG	0.647			NA											8	28					0	0	0.00308	0	0
RGN	9104	broad.mit.edu	37	X	46949272	46949272	+	Silent	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:46949272C>T	uc004dgz.1	+	5	1413	c.444C>T	c.(442-444)GAC>GAT	p.D148D	RGN_uc004dha.1_Silent_p.D148D|RGN_uc010nho.1_Silent_p.D95D|RGN_uc010nhp.1_Intron	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	148					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						AGTACTTTGACCAGGTGGACA	0.502			NA											18	61					0	0	0.00499	0	0
XAGE5	170627	broad.mit.edu	37	X	52842245	52842245	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:52842245G>T	uc004drd.1	+	3	219	c.154G>T	c.(154-156)GAT>TAT	p.D52Y		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	52										ovary(1)	1						GAGAGAAGATGATCAGGGTGC	0.547			NA											10	35					1.08611e-07	1.30915e-07	0.010729	1	0
HUWE1	10075	broad.mit.edu	37	X	53578393	53578393	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:53578393G>T	uc004dsp.2	-	64	9332	c.8930C>A	c.(8929-8931)CCT>CAT	p.P2977H	HUWE1_uc004dsn.2_Missense_Mutation_p.P1801H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2977					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GATGTCATCAGGCAGGGCAGC	0.527			NA											3	13					0.004672	0.00481466	0.004672	1	0
WNK3	65267	broad.mit.edu	37	X	54224971	54224972	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:54224971_54224972GG>AT	uc004dtd.1	-	23	5456_5457	c.5017_5018CC>AT	c.(5017-5019)CCA>ATA	p.P1673I	WNK3_uc004dtc.1_Missense_Mutation_p.P1730I|uc004dtb.1_5'Flank	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1673					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TGATGATAATGGCCCAGGAAAT	0.485			NA											25	30					0	0	0.004672	0	0
PFKFB1	5207	broad.mit.edu	37	X	54982650	54982650	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:54982650C>A	uc004dty.1	-	7	645	c.574G>T	c.(574-576)GAC>TAC	p.D192Y	PFKFB1_uc010nkd.1_Intron|PFKFB1_uc011mol.1_Missense_Mutation_p.D127Y	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	192	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TTTAGAAAGTCTTCCAGAACC	0.353			NA											21	44					6.44725e-10	8.31572e-10	0.014323	1	0
ZXDA	7789	broad.mit.edu	37	X	57936549	57936549	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:57936549G>T	uc004dve.2	-	1	519	c.306C>A	c.(304-306)ACC>ACA	p.T102T		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	102					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGGAGCCCGCGGTCTCCACGT	0.736			NA											6	15					2.7689e-08	3.38792e-08	0.001984	1	0
FAM123B	139285	broad.mit.edu	37	X	63413106	63413106	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:63413106G>T	uc004dvo.2	-	2	334	c.61C>A	c.(61-63)CGT>AGT	p.R21S		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	21					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GTTTGTTCACGGGTACTCCCA	0.552			NA											32	124					2.81731e-10	3.66885e-10	0.010818	1	0
MED12	9968	broad.mit.edu	37	X	70345265	70345265	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:70345265G>A	uc004dyy.2	+	16	2490	c.2291G>A	c.(2290-2292)CGA>CAA	p.R764Q	MED12_uc011mpq.1_Missense_Mutation_p.R764Q|MED12_uc004dyz.2_Missense_Mutation_p.R764Q|MED12_uc004dza.2_Missense_Mutation_p.R611Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	764					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGAAAGCAGCGAGATGATGCC	0.537			NA											9	21					0	0	0.004482	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004593	75004593	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:75004593G>A	uc004ecj.1	-	1	479	c.294C>T	c.(292-294)TTC>TTT	p.F98F		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	98	MAGE 1.									ovary(1)|skin(1)	2						TCATTCTCATGAAATTCACCA	0.532			NA											10	148					0	0	0.008291	0	0
NXF5	55998	broad.mit.edu	37	X	101095988	101095988	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:101095988C>A	uc011mrk.1	-	8	840	c.480G>T	c.(478-480)GAG>GAT	p.E160D	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	160	LRR 1.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						AAGGCTTCACCTCAGGGAAAT	0.493			NA											53	114					1.93748e-29	3.51874e-29	0.01441	1	0
PLP1	5354	broad.mit.edu	37	X	103041586	103041586	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:103041586C>A	uc010nov.2	+	4	664	c.384C>A	c.(382-384)GGC>GGA	p.G128G	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.G128G|PLP1_uc004elj.2_Intron|PLP1_uc011msf.1_Silent_p.G73G|PLP1_uc010now.1_Silent_p.G132G|PLP1_uc010nox.2_Silent_p.G82G	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	128	Cytoplasmic (Probable).		Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				ovary(1)	1						GTTCCAGAGGCCAACATCAAG	0.547			NA											41	128					6.48837e-15	9.6256e-15	0.010771	1	0
LHFPL1	340596	broad.mit.edu	37	X	111914366	111914366	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:111914366T>A	uc004epq.2	-	2	586	c.253A>T	c.(253-255)ACA>TCA	p.T85S	LHFPL1_uc004epp.2_Missense_Mutation_p.T108S|LHFPL1_uc010nqa.2_Intron|LHFPL1_uc010nqb.2_Missense_Mutation_p.T85S	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	85						integral to membrane					0						GTCACCACTGTGCACATCTGC	0.597			NA											19	36					0	0	0.008871	0	0
PLS3	5358	broad.mit.edu	37	X	114863589	114863589	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:114863589T>A	uc004eqd.2	+	4	707	c.317T>A	c.(316-318)CTG>CAG	p.L106Q	PLS3_uc010nqf.2_RNA|PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Missense_Mutation_p.L84Q|PLS3_uc004eqe.2_Missense_Mutation_p.L106Q|PLS3_uc011mtg.1_Missense_Mutation_p.L79Q|PLS3_uc011mth.1_Missense_Mutation_p.L61Q	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	106						cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						ATTTGTGCTCTGGGTGGAACT	0.373	Colon(160;1047 1864 8490 12969 29601)		NA											27	57					0	0	0.00632	0	0
CXorf56	63932	broad.mit.edu	37	X	118676546	118676546	+	Silent	SNP	G	G	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:118676546G>T	uc004erk.1	-	5	481	c.435C>A	c.(433-435)ACC>ACA	p.T145T	CXorf56_uc004erj.1_Silent_p.T96T|CXorf56_uc011mtu.1_Silent_p.T131T	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	145							protein binding				0						TGGTCCGTTTGGTCATCATCA	0.522			NA											27	78					1.77063e-15	2.64615e-15	0.005443	1	0
FAM70A	55026	broad.mit.edu	37	X	119410885	119410885	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:119410885C>A	uc004eso.3	-	8	829	c.602G>T	c.(601-603)GGT>GTT	p.G201V	FAM70A_uc004esp.3_Missense_Mutation_p.G177V|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	201						integral to membrane				lung(1)|breast(1)	2						GTAGTACCCACCAGTGATCTC	0.587			NA											20	93					2.94398e-08	3.5913e-08	0.007413	1	0
GRIA3	2892	broad.mit.edu	37	X	122528962	122528962	+	Silent	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:122528962C>A	uc004etq.3	+	7	1187	c.894C>A	c.(892-894)GCC>GCA	p.A298A	GRIA3_uc004etr.3_Silent_p.A298A|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Silent_p.A282A	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	298	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TCCCTGAAGCCAAGAATGCAC	0.418			NA											30	82					2.81731e-10	3.66885e-10	0.010818	1	0
ODZ1	10178	broad.mit.edu	37	X	123657421	123657421	+	Silent	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:123657421G>A	uc004euj.2	-	17	2890	c.2826C>T	c.(2824-2826)TCC>TCT	p.S942S	ODZ1_uc011muj.1_Silent_p.S941S|ODZ1_uc010nqy.2_Silent_p.S942S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	942	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GCAGGAAAGGGGATCGGTCGA	0.443			NA											15	39					0	0	0.003163	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685987	125685987	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:125685987C>A	uc004eul.2	-	1	856	c.605G>T	c.(604-606)TGG>TTG	p.W202L		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	202	WD 2.									skin(3)|ovary(1)	4						GTCACTCAGCCAGGCGACGGC	0.652			NA											15	29					2.23348e-06	2.59931e-06	0.004007	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125686176	125686176	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:125686176C>A	uc004eul.2	-	1	667	c.416G>T	c.(415-417)AGT>ATT	p.S139I		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	139										skin(3)|ovary(1)	4						CCTGGCCTCACTGTCCCGCAA	0.632			NA											20	44					2.70639e-06	3.14066e-06	0.014323	1	0
VGLL1	51442	broad.mit.edu	37	X	135630964	135630964	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:135630964C>A	uc004ezy.2	+	3	601	c.431C>A	c.(430-432)CCT>CAT	p.P144H	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					TCCTTAGAGCCTGGCTACTCT	0.617			NA											31	105					5.45727e-16	8.27788e-16	0.008361	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795227	142795227	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:142795227C>A	uc004fbz.2	-	2	1205	c.451G>T	c.(451-453)GAC>TAC	p.D151Y		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	151										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCTTCGTCCTCCTGTGAA	0.512			NA											113	345					9.50027e-55	1.89537e-54	0.01441	1	0
HAUS7	55559	broad.mit.edu	37	X	152721026	152721026	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:152721026G>A	uc004fho.1	-	8	1492	c.934C>T	c.(934-936)CAC>TAC	p.H312Y	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Missense_Mutation_p.H312Y|HAUS7_uc004fhp.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	312					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0						AGATTCTGGTGCGTGGCCTGG	0.602			NA											7	43					0	0	0.001984	0	0
FLNA	2316	broad.mit.edu	37	X	153590914	153590914	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chrX:153590914C>T	uc004fkk.2	-	17	2686	c.2437G>A	c.(2437-2439)GGA>AGA	p.G813R	FLNA_uc010nuu.1_Missense_Mutation_p.G813R	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	813	Filamin 6.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTACCACTCCAGGGGCACAC	0.652			NA											23	115					0	0	0.003954	0	0
FBXO2	26232	broad.mit.edu	37	1	11710099	11710100	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:11710099_11710100insA	uc001asj.2	-	3	765_766	c.423_424insT	c.(421-426)CATGGTfs	p.H141fs	FBXO2_uc009vna.2_Frame_Shift_Ins_p.H141fs|FBXO2_uc009vnb.1_RNA	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	141_142	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CCGTCCCCACCATGCTCCACGT	0.599			NA											23	147	---	---	---	---	NA	NA	NA	NA	NA
UBR4	23352	broad.mit.edu	37	1	19481480	19481480	+	Frame_Shift_Del	DEL	T	T	-	rs149131327		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:19481480delT	uc001bbi.2	-	44	6394	c.6390delA	c.(6388-6390)AAAfs	p.K2130fs	UBR4_uc001bbl.1_Frame_Shift_Del_p.K67fs|UBR4_uc001bbm.1_Frame_Shift_Del_p.K1342fs	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2130					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTGCGAATGATTTGCCTTGAC	0.512			NA											15	119	---	---	---	---	NA	NA	NA	NA	NA
NLRP3	114548	broad.mit.edu	37	1	247588869	247588869	+	Frame_Shift_Del	DEL	C	C	-	rs149493236		TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr1:247588869delC	uc001icr.2	+	5	2262	c.2124delC	c.(2122-2124)CTCfs	p.L708fs	NLRP3_uc001ics.2_Frame_Shift_Del_p.L708fs|NLRP3_uc001icu.2_Frame_Shift_Del_p.L708fs|NLRP3_uc001icw.2_Frame_Shift_Del_p.L708fs|NLRP3_uc001icv.2_Frame_Shift_Del_p.L708fs|NLRP3_uc010pyw.1_Frame_Shift_Del_p.L706fs|NLRP3_uc001ict.1_Frame_Shift_Del_p.L706fs	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	708					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGTGTGTCCTCCCAAGCTCCT	0.567			NA											21	74	---	---	---	---	NA	NA	NA	NA	NA
AKR1C2	1646	broad.mit.edu	37	10	5040858	5040859	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr10:5040858_5040859delGG	uc010qan.1	-	5	707_708	c.528_529delCC	c.(526-531)ATCCTCfs	p.I176fs	AKR1E2_uc001ihl.1_Intron|AKR1C3_uc001ihr.2_Intron|AKR1C2_uc009xhy.2_Frame_Shift_Del_p.I150fs|AKR1C2_uc001ihs.2_Frame_Shift_Del_p.I176fs|AKR1C2_uc001iht.2_Frame_Shift_Del_p.I176fs	NM_205845	NP_995317	P52895	AK1C2_HUMAN	aldo-keto reductase family 1, member C2	176_177					digestion|prostaglandin metabolic process|steroid metabolic process	cytoplasm	androsterone dehydrogenase (A-specific) activity|bile acid binding|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0					NADH(DB00157)|Ursodeoxycholic acid(DB01586)	GGCTTGTTGAGGATCATCTCCA	0.525			NA											10	57	---	---	---	---	NA	NA	NA	NA	NA
SYT9	143425	broad.mit.edu	37	11	7441837	7441837	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:7441837delC	uc001mfe.2	+	6	1675	c.1438delC	c.(1438-1440)CCCfs	p.P480fs	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	480	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TCCTCGGAAGCCCATTGCACA	0.502			NA											33	47	---	---	---	---	NA	NA	NA	NA	NA
CHST1	8534	broad.mit.edu	37	11	45671461	45671461	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr11:45671461delC	uc001mys.1	-	4	1684	c.1013delG	c.(1012-1014)GGCfs	p.G338fs		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	338	Lumenal (Potential).|Cell attachment site (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GGTGGGGTCGCCCCGCGTGTT	0.642			NA											40	72	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	140997062	140997062	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr2:140997062delG	uc002tvj.1	-	88	14336	c.13364delC	c.(13363-13365)ACTfs	p.T4455fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4455	Helical; (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTTATCAAAGTCACCAAGAG	0.294	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	12	---	---	---	---	NA	NA	NA	NA	NA
CPB1	1360	broad.mit.edu	37	3	148558565	148558565	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr3:148558565delG	uc003ewl.2	+	4	388	c.365delG	c.(364-366)TGGfs	p.W122fs		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	122					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TACAACAAGTGGGAAACGGTA	0.423			NA											24	64	---	---	---	---	NA	NA	NA	NA	NA
NEDD9	4739	broad.mit.edu	37	6	11185423	11185423	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr6:11185423delC	uc003mzv.2	-	7	2644	c.2477delG	c.(2476-2478)CGCfs	p.R826fs	NEDD9_uc010joz.2_Frame_Shift_Del_p.R826fs|NEDD9_uc003mzw.3_Frame_Shift_Del_p.R680fs	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	826					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CAGCAAAGAGCGCTTGAACAG	0.498			NA											7	78	---	---	---	---	NA	NA	NA	NA	NA
LAMB1	3912	broad.mit.edu	37	7	107569639	107569640	+	Frame_Shift_Ins	INS	-	-	T			TCGA-49-4488-01A-01D-1753-08	TCGA-49-4488-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3635bb9c-a332-4445-ad81-83cec426dd02	232307bb-5ab4-48c2-a008-8684ce7e1056	g.chr7:107569639_107569640insT	uc003vew.2	-	31	5091_5092	c.4756_4757insA	c.(4756-4758)ACAfs	p.T1586fs	LAMB1_uc003vev.2_Frame_Shift_Ins_p.T1610fs|LAMB1_uc003veu.2_Frame_Shift_Ins_p.T69fs	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1586	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTAACATCTGTTGCACTTTTG	0.386			NA											77	72	---	---	---	---	NA	NA	NA	NA	NA
