Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTCHD2	57540	broad.mit.edu	37	1	11561297	11561297	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:11561297G>T	uc001ash.3	+	2	386	c.248G>T	c.(247-249)AGC>ATC	p.S83I	PTCHD2_uc001asi.1_Missense_Mutation_p.S83I	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	83	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CTGGGCTGCAGCATCCCCATG	0.612			NA											17	80					1.56452e-12	2.83849e-12	0.007413	1	0
PTPRU	10076	broad.mit.edu	37	1	29606079	29606079	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:29606079C>T	uc001bru.2	+	10	1785	c.1675C>T	c.(1675-1677)CCA>TCA	p.P559S	PTPRU_uc001brv.2_Missense_Mutation_p.P559S|PTPRU_uc001brw.2_Missense_Mutation_p.P559S|PTPRU_uc009vtq.2_Missense_Mutation_p.P559S|PTPRU_uc009vtr.2_Missense_Mutation_p.P559S	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	559	Extracellular (Potential).|Fibronectin type-III 3.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CAACCTGCACCCAGGCACCAC	0.602			NA											10	162					0	0	0.008291	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43632904	43632904	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:43632904C>A	uc001cin.2	-	6	737	c.540G>T	c.(538-540)GTG>GTT	p.V180V	EBNA1BP2_uc001cio.2_Silent_p.V235V|EBNA1BP2_uc001cim.2_Silent_p.V75V|EBNA1BP2_uc010ojx.1_Silent_p.V235V	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	180					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTCCGTTTGCACCTGTGATA	0.418			NA											14	147					6.31663e-08	1.01119e-07	0.003163	1	0
EFCAB7	84455	broad.mit.edu	37	1	63998406	63998406	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:63998406T>A	uc001dbf.2	+	4	759	c.465T>A	c.(463-465)GAT>GAA	p.D155E		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	155	EF-hand 2.						calcium ion binding				0						TAAATGCTGATGGCAAATTTG	0.274			NA											12	100					0	0	0.001855	0	0
SPAG17	200162	broad.mit.edu	37	1	118566053	118566053	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:118566053G>T	uc001ehk.2	-	28	4011	c.3943C>A	c.(3943-3945)CCC>ACC	p.P1315T		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1315						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCTGAATTGGGACTCCTGCTC	0.423			NA											4	66					1.6384e-10	2.82457e-10	0.001984	1	0
ITGA10	8515	broad.mit.edu	37	1	145536120	145536120	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:145536120C>T	uc001eoa.2	+	17	2288	c.2212C>T	c.(2212-2214)CAG>TAG	p.Q738*	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Nonsense_Mutation_p.Q607*|ITGA10_uc009wiw.2_Nonsense_Mutation_p.Q595*|ITGA10_uc010oyw.1_Nonsense_Mutation_p.Q683*	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	738	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CACTTGTGAGCAGCTACACTT	0.552			NA											23	70					0	0	0.00278	0	0
PIAS3	10401	broad.mit.edu	37	1	145580301	145580301	+	Silent	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:145580301T>C	uc001eoc.1	+	6	874	c.783T>C	c.(781-783)AAT>AAC	p.N261N	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_Silent_p.N252N|PIAS3_uc001eod.1_5'Flank	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	261	PINIT.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGGTCAATTGGTCATCTG	0.587			NA											5	139					0	0	0.000602	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149785214	149785214	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:149785214G>A	uc010pbl.1	-	1	23	c.23C>T	c.(22-24)GCC>GTC	p.A8V	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	8					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						CGACTTGCGGGCAGTCTGCTT	0.602			NA											4	50					0	0	0.000602	0	0
FLG	2312	broad.mit.edu	37	1	152283027	152283027	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:152283027C>T	uc001ezu.1	-	3	4371	c.4335G>A	c.(4333-4335)GTG>GTA	p.V1445V	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1445	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGAGAGCTCACCTGGTAGA	0.587			NA							Ichthyosis				12	333					0	0	0.001368	0	0
FLG2	388698	broad.mit.edu	37	1	152328814	152328814	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:152328814C>A	uc001ezw.3	-	3	1521	c.1448G>T	c.(1447-1449)GGG>GTG	p.G483V	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	483	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGCCAGACCCATGTTGTCC	0.527			NA											38	335					1.90571e-15	3.61231e-15	0.004289	1	0
PEAR1	375033	broad.mit.edu	37	1	156878710	156878710	+	Silent	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:156878710C>G	uc001fqj.1	+	11	1409	c.1293C>G	c.(1291-1293)GGC>GGG	p.G431G	PEAR1_uc009wsl.1_Silent_p.G232G|PEAR1_uc001fqk.1_Silent_p.G56G	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	431	EGF-like 5.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TCTTTCAGGGCCCTCACTGTG	0.627			NA											16	57					0	0	0.006122	0	0
DUSP27	92235	broad.mit.edu	37	1	167095997	167095997	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:167095997C>A	uc001geb.1	+	5	1629	c.1629C>A	c.(1627-1629)GCC>GCA	p.A543A		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	543					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGCTCACTGCCCTGGAAAGAT	0.552			NA											10	91					2.17888e-05	2.96483e-05	0.006214	1	0
F5	2153	broad.mit.edu	37	1	169511383	169511383	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:169511383C>T	uc001ggg.1	-	13	3090	c.2945G>A	c.(2944-2946)TGG>TAG	p.W982*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	982	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GCTTTCTCCCCAAGCACGTGA	0.463			NA											12	206					0	0	0.000978	0	0
C1orf129	80133	broad.mit.edu	37	1	170961380	170961380	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:170961380G>C	uc001ghg.2	+	12	1234	c.1104G>C	c.(1102-1104)TTG>TTC	p.L368F	C1orf129_uc009wvy.2_Missense_Mutation_p.L175F|C1orf129_uc010plz.1_Missense_Mutation_p.L368F	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	368							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAATCTTATTGATACTGAAAG	0.502			NA											8	95					0	0	0.00308	0	0
FMO2	2327	broad.mit.edu	37	1	171154954	171154954	+	Silent	SNP	T	T	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:171154954T>G	uc001ghk.1	+	2	219	c.102T>G	c.(100-102)ACT>ACG	p.T34T	FMO2_uc010pmd.1_Intron	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	34					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTGAGAGAACTGAAGATATTG	0.458			NA											9	188					0	0	0.006214	0	0
SLC9A11	284525	broad.mit.edu	37	1	173517545	173517545	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:173517545T>C	uc001giz.2	-	12	1867	c.1444A>G	c.(1444-1446)AGG>GGG	p.R482G	SLC9A11_uc009wwe.2_Missense_Mutation_p.R40G|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	482					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TATTCGATCCTCGTTTTATCT	0.368			NA											3	85					0	0	0.000248	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525866	176525866	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:176525866G>A	uc001gkz.2	+	2	1572	c.408G>A	c.(406-408)GGG>GGA	p.G136G	PAPPA2_uc001gky.1_Silent_p.G136G|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	136					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GTCCTATTGGGCAATCTGAGC	0.557			NA											5	155					0	0	0.000602	0	0
ASTN1	460	broad.mit.edu	37	1	176845741	176845741	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:176845741C>A	uc001glc.2	-	21	3607	c.3395G>T	c.(3394-3396)CGG>CTG	p.R1132L	ASTN1_uc001glb.1_Missense_Mutation_p.R1132L|ASTN1_uc001gld.1_Missense_Mutation_p.R1132L	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1140	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CCTGGAGCGCCGTCCTGTGTT	0.572			NA											8	49					1.12685e-05	1.57264e-05	0.004482	1	0
TDRD5	163589	broad.mit.edu	37	1	179562702	179562702	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:179562702G>T	uc001gnf.1	+	3	590	c.340G>T	c.(340-342)GGA>TGA	p.G114*	TDRD5_uc010pnp.1_Nonsense_Mutation_p.G114*	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	114					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TATTTATTCTGGACCGAGATC	0.463			NA											4	80					2.56e-06	3.6806e-06	0.000248	1	0
HMCN1	83872	broad.mit.edu	37	1	186122916	186122916	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:186122916G>A	uc001grq.1	+	97	15282	c.15053G>A	c.(15052-15054)GGG>GAG	p.G5018E	HMCN1_uc001grs.1_Missense_Mutation_p.G587E	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5018	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACAGGTCCTGGGCAGCTGTAC	0.458			NA											7	61					0	0	0.00308	0	0
PTGS2	5743	broad.mit.edu	37	1	186645168	186645168	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:186645168C>G	uc001gsb.2	-	8	1256	c.1119G>C	c.(1117-1119)TGG>TGC	p.W373C	PTGS2_uc009wyo.2_Missense_Mutation_p.W220C	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	373					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GAAGGGGATGCCAGTGATAGA	0.383			NA											8	135					0	0	0.006214	0	0
UCHL5	51377	broad.mit.edu	37	1	192992151	192992151	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:192992151C>T	uc001gsm.2	-	9	882	c.751G>A	c.(751-753)GAT>AAT	p.D251N	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Missense_Mutation_p.D250N|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Missense_Mutation_p.D250N|UCHL5_uc001gsq.2_Missense_Mutation_p.D250N|UCHL5_uc010pow.1_Missense_Mutation_p.D126N|UCHL5_uc010pox.1_Missense_Mutation_p.D127N	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	251					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						TTACCTTGATCTGTATCCATG	0.338			NA											11	177					0	0	0.008291	0	0
DDX59	83479	broad.mit.edu	37	1	200635159	200635159	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:200635159C>T	uc009wzk.2	-	2	953	c.710G>A	c.(709-711)GGA>GAA	p.G237E	DDX59_uc010ppl.1_Missense_Mutation_p.G237E	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	237	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCCCAGAAGTCCCACAGGAAT	0.443			NA											10	157					0	0	0.000978	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379882	204379882	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:204379882A>T	uc001hav.3	-	1	1063	c.658T>A	c.(658-660)TCC>ACC	p.S220T		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	220					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			AGCAAATAGGATACCACACTG	0.498			NA											6	113					0	0	0.001984	0	0
USH2A	7399	broad.mit.edu	37	1	216172314	216172314	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:216172314C>G	uc001hku.1	-	34	6959	c.6572G>C	c.(6571-6573)AGT>ACT	p.S2191T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2191	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATAGATGACACTCCAAATTGT	0.343			NA								HNSCC(13;0.011)			4	96					0	0	0.000248	0	0
USH2A	7399	broad.mit.edu	37	1	216595317	216595317	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:216595317T>C	uc001hku.1	-	2	749	c.362A>G	c.(361-363)CAT>CGT	p.H121R	USH2A_uc001hkv.2_Missense_Mutation_p.H121R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	121	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGAATTGCTATGGGCGTTAGG	0.458			NA								HNSCC(13;0.011)			3	89					0	0	0.004672	0	0
HEATR1	55127	broad.mit.edu	37	1	236730018	236730018	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:236730018G>A	uc001hyd.1	-	30	4361	c.4236C>T	c.(4234-4236)CTC>CTT	p.L1412L	HEATR1_uc009xgh.1_Silent_p.L574L	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1412					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GGAGAATCCAGAGGAATTTCT	0.498			NA											4	37					0	0	0.000248	0	0
RYR2	6262	broad.mit.edu	37	1	237843805	237843805	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:237843805T>G	uc001hyl.1	+	62	9065	c.8945T>G	c.(8944-8946)TTC>TGC	p.F2982C	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2982	Modulator (Potential).|Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGTTTATACTTCTTATCTGCA	0.388			NA											3	32					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237886560	237886560	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:237886560C>A	uc001hyl.1	+	74	10807	c.10687C>A	c.(10687-10689)CAG>AAG	p.Q3563K	RYR2_uc010pxz.1_Missense_Mutation_p.Q518K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3563					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCATCTTGAACAGGTCAGGCT	0.348			NA											9	96					2.17888e-05	2.96483e-05	0.006214	1	0
WDR64	128025	broad.mit.edu	37	1	241913018	241913018	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:241913018G>T	uc001hzf.1	+	8	1047	c.894G>T	c.(892-894)ATG>ATT	p.M298I	WDR64_uc001hzg.1_Missense_Mutation_p.M44I	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	578	WD 8.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CTATCAAAATGATCCAGGTTT	0.502			NA											16	96					3.52763e-06	5.03381e-06	0.00499	1	0
SMYD3	64754	broad.mit.edu	37	1	246493833	246493833	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:246493833C>T	uc001ibl.2	-	4	438	c.343G>A	c.(343-345)GGA>AGA	p.G115R	SMYD3_uc001ibk.2_Missense_Mutation_p.G56R	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	115						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		GAAGGTGCTCCATCCATCTGT	0.318			NA											6	101					0	0	0.001168	0	0
OR2M4	26245	broad.mit.edu	37	1	248402509	248402509	+	Silent	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr1:248402509T>C	uc010pzh.1	+	1	279	c.279T>C	c.(277-279)TCT>TCC	p.S93S		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AATCTATCTCTCTGGCAGGTT	0.463			NA											12	101					0	0	0.000978	0	0
CUBN	8029	broad.mit.edu	37	10	16975090	16975090	+	Silent	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:16975090T>A	uc001ioo.2	-	40	6172	c.6120A>T	c.(6118-6120)CGA>CGT	p.R2040R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2040	CUB 14.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTCACCATCTCGTATCACAA	0.458			NA											4	71					0	0	0.000602	0	0
CUL2	8453	broad.mit.edu	37	10	35349836	35349836	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:35349836T>A	uc001ixv.2	-	4	493	c.283A>T	c.(283-285)AGC>TGC	p.S95C	CUL2_uc009xma.2_5'UTR|CUL2_uc010qer.1_Missense_Mutation_p.S114C|CUL2_uc001ixw.2_Missense_Mutation_p.S95C|CUL2_uc010qes.1_Missense_Mutation_p.S95C	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	95				SKGA -> IRHE (in Ref. 7; AAC50545).	cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						GCACCCTTGCTGTATTCTTCC	0.368			NA											13	64					0	0	0.001368	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088981	43088981	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:43088981C>G	uc001jaf.1	-	5	1532	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.E361Q|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	473	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTCCCACACTCAAGACATTCA	0.378	Melanoma(137;1247 1767 16772 25727 43810)		NA											3	69					0	0	0.004672	0	0
MARCH8	220972	broad.mit.edu	37	10	45953764	45953764	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:45953764C>A	uc001jci.1	-	7	1038	c.799G>T	c.(799-801)GGA>TGA	p.G267*	MARCH8_uc001jch.2_Nonsense_Mutation_p.G549*|MARCH8_uc001jcj.1_Nonsense_Mutation_p.G267*|MARCH8_uc001jck.1_Nonsense_Mutation_p.G267*|uc001jcf.2_5'Flank|MARCH8_uc001jcg.1_Nonsense_Mutation_p.G136*	NM_001002266	NP_001002266	Q5T0T0	MARH8_HUMAN	cellular modulator of immune recognition isoform	267						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TGACAGATTCCATATCCATGT	0.388	NSCLC(102;658 1594 2173 16344 34808)		NA											12	106					2.80697e-09	4.67012e-09	0.000978	1	0
ZWINT	11130	broad.mit.edu	37	10	58118214	58118214	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:58118214C>A	uc001jjx.1	-	8	836	c.799G>T	c.(799-801)GGT>TGT	p.G267C	ZWINT_uc001jjy.1_Missense_Mutation_p.G220C|ZWINT_uc001jka.1_Missense_Mutation_p.G267C	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	267					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						GGTTGTAGACCAACAGCCTTG	0.502			NA											16	69					1.15088e-07	1.78973e-07	0.004007	1	0
MYPN	84665	broad.mit.edu	37	10	69954182	69954182	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:69954182A>T	uc001jnm.3	+	15	3173	c.2988A>T	c.(2986-2988)CGA>CGT	p.R996R	MYPN_uc001jnn.3_Silent_p.R721R|MYPN_uc001jno.3_Silent_p.R996R|MYPN_uc009xpt.2_Silent_p.R996R|MYPN_uc010qit.1_Silent_p.R702R|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	996	Ig-like 3.|Interaction with ACTN.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						AAATGAGGCGAGAAGGAGATG	0.453			NA											6	26					0	0	0.001984	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511354	72511354	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:72511354G>T	uc001jrh.2	+	17	2548	c.2548G>T	c.(2548-2550)GAG>TAG	p.E850*	ADAMTS14_uc001jrg.2_Nonsense_Mutation_p.E853*	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	850	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGACACCTATGAGTGGGCGCT	0.627			NA											9	49					3.09899e-07	4.78022e-07	0.004482	1	0
PDE6C	5146	broad.mit.edu	37	10	95380394	95380394	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:95380394C>T	uc001kiu.3	+	2	624	c.486C>T	c.(484-486)AGC>AGT	p.S162S		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	162	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTCAGAACAGCCATTTTTCTG	0.443			NA											10	98					0	0	0.006214	0	0
CHUK	1147	broad.mit.edu	37	10	101977791	101977791	+	Silent	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:101977791T>A	uc001kqp.2	-	9	949	c.894A>T	c.(892-894)CCA>CCT	p.P298P		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	298	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CAAAACATCTTGGCTGCTTCA	0.388	Ovarian(159;52 1904 10536 35305 37148)		NA											7	40					0	0	0.004482	0	0
FAM178A	55719	broad.mit.edu	37	10	102683760	102683760	+	Silent	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:102683760A>G	uc001krt.3	+	5	1544	c.1002A>G	c.(1000-1002)GAA>GAG	p.E334E	FAM178A_uc001krr.1_Silent_p.E334E|FAM178A_uc001krs.2_Silent_p.E334E|FAM178A_uc001kru.1_Silent_p.E269E	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	334											0						AATTCCCTGAAAAAAGAAAAA	0.348			NA											4	31					0	0	0.000248	0	0
SORCS3	22986	broad.mit.edu	37	10	106865208	106865208	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:106865208G>T	uc001kyi.1	+	7	1374	c.1147G>T	c.(1147-1149)GGG>TGG	p.G383W		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	383	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AACTAGAAGTGGGCCTTTTGC	0.473	NSCLC(116;1497 1690 7108 13108 14106)		NA											6	128					3.59834e-05	4.72747e-05	0.001168	1	0
SLC18A2	6571	broad.mit.edu	37	10	119029956	119029956	+	Silent	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:119029956T>A	uc001ldd.1	+	15	1453	c.1422T>A	c.(1420-1422)CCT>CCA	p.P474P	SLC18A2_uc009xyy.1_Silent_p.P271P	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	474	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	GAAGTCCACCTGCCAAAGAAG	0.378			NA											4	59					0	0	0.000602	0	0
PSTK	118672	broad.mit.edu	37	10	124740146	124740146	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:124740146G>A	uc001lgy.1	+	1	591	c.151G>A	c.(151-153)GGT>AGT	p.G51S		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	51							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		TTGGGCCATCGGTGTTGTCGC	0.682			NA									OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	17					0	0	0.000602	0	0
EBF3	253738	broad.mit.edu	37	10	131640445	131640445	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr10:131640445C>G	uc001lki.1	-	13	1339	c.1280G>C	c.(1279-1281)GGC>GCC	p.G427A		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	436					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGAGTTGACGCCCATCATGCC	0.617			NA											5	118					0	0	0.001984	0	0
MMP26	56547	broad.mit.edu	37	11	5011842	5011842	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:5011842C>A	uc001lzv.2	+	3	353	c.335C>A	c.(334-336)CCA>CAA	p.P112Q		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	112					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATCAATTACCCACATGATATG	0.388			NA											6	77					3.59834e-05	4.72747e-05	0.001168	1	0
OR51B5	282763	broad.mit.edu	37	11	5364598	5364598	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:5364598G>T	uc001map.1	-	1	157	c.157C>A	c.(157-159)CTT>ATT	p.L53I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Missense_Mutation_p.L53I	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	53	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTCATGAAGATTGTGATCT	0.502			NA											7	64					2.0095e-06	2.9334e-06	0.001984	1	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5624904	5624904	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:5624904G>A	uc001mbf.2	+	2	690	c.446G>A	c.(445-447)CGG>CAG	p.R149Q	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Missense_Mutation_p.R95Q|TRIM6_uc010qzj.1_5'UTR|TRIM6_uc001mbc.1_Missense_Mutation_p.R121Q|TRIM6_uc001mbe.2_5'UTR|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Missense_Mutation_p.R149Q|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	149						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CTTTGTGAGCGGTCTCAGGAG	0.557			NA											6	86					0	0	0.001984	0	0
OR52E6	390078	broad.mit.edu	37	11	5862540	5862540	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:5862540G>T	uc010qzq.1	-	1	588	c.588C>A	c.(586-588)GTC>GTA	p.V196V	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATAATGTTGACTTTGATGC	0.463			NA											27	85					1.17739e-12	2.14635e-12	0.005443	1	0
DCHS1	8642	broad.mit.edu	37	11	6650685	6650685	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:6650685G>A	uc001mem.1	-	12	5569	c.5159C>T	c.(5158-5160)ACA>ATA	p.T1720I		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1720	Cadherin 16.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATGTACCTGTCAGGTTGAT	0.493			NA											5	20					0	0	0.000602	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806622	6806622	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:6806622G>T	uc001mer.1	+	1	354	c.354G>T	c.(352-354)ATG>ATT	p.M118I		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGGCCTTCATGGCCTATGACA	0.547			NA											9	67					1.12685e-05	1.57264e-05	0.004482	1	0
SYT9	143425	broad.mit.edu	37	11	7324269	7324269	+	Splice_Site	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:7324269G>C	uc001mfe.2	+	2	383	c.146_splice	c.e2-1	p.D49_splice	SYT9_uc001mfd.2_Splice_Site|SYT9_uc009yfi.2_Splice_Site	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX							cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTTCTTTGCAGATATCTCAGT	0.537			NA											19	131					0	0	0.001882	0	0
LUZP2	338645	broad.mit.edu	37	11	25098875	25098875	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:25098875G>A	uc001mqs.2	+	11	1093	c.859G>A	c.(859-861)GAG>AAG	p.E287K	LUZP2_uc009yif.2_Missense_Mutation_p.E201K|LUZP2_uc009yig.2_Missense_Mutation_p.E245K	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	287						extracellular region				ovary(1)|skin(1)	2						ACTTTTGTAGGAGGGCAGACC	0.408			NA											9	156					0	0	0.004482	0	0
LDLRAD3	143458	broad.mit.edu	37	11	36057670	36057670	+	Missense_Mutation	SNP	G	G	C	rs144816501		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:36057670G>C	uc001mwk.1	+	2	101	c.64G>C	c.(64-66)GGG>CGG	p.G22R	LDLRAD3_uc010rey.1_Intron|LDLRAD3_uc010rez.1_Intron	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	22	Extracellular (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				GCTGCTCCCCGGGAACAACTT	0.597			NA											3	57					0	0	0.004672	0	0
OR4A5	81318	broad.mit.edu	37	11	51412225	51412225	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:51412225C>T	uc001nhi.1	-	1	171	c.171G>A	c.(169-171)ATG>ATA	p.M57I		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GGAAGAAATACATTGGGGAAC	0.403			NA											4	61					0	0	0.000248	0	0
OR4P4	81300	broad.mit.edu	37	11	55406405	55406406	+	Missense_Mutation	DNP	AC	AC	CA			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:55406405_55406406AC>CA	uc010rij.1	+	1	572_573	c.572_573AC>CA	c.(571-573)CAC>CCA	p.H191P		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCTAATATACACATGATAGGTC	0.356			NA											9	44					0	0	0.004672	0	0
OR5L2	26338	broad.mit.edu	37	11	55594859	55594859	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:55594859C>A	uc001nhy.1	+	1	165	c.165C>A	c.(163-165)CTC>CTA	p.L55L		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GCTCTCGGCTCCACACCCCCG	0.468			NA								HNSCC(27;0.073)			20	309					2.4624e-09	4.13292e-09	0.008871	1	0
P2RX3	5024	broad.mit.edu	37	11	57114033	57114033	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:57114033C>T	uc001nju.2	+	2	211	c.135C>T	c.(133-135)CAC>CAT	p.H45H		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	45	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						TTTTCTTGCACGAGAAGGCTT	0.547			NA											5	53					0	0	0.000602	0	0
OR5B17	219965	broad.mit.edu	37	11	58125859	58125859	+	Silent	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:58125859T>A	uc010rke.1	-	1	684	c.684A>T	c.(682-684)ACA>ACT	p.T228T		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATCCCTTACCTGTGTGCCTCT	0.348			NA											12	39					0	0	0.000978	0	0
VWCE	220001	broad.mit.edu	37	11	61026563	61026563	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:61026563C>T	uc001nra.2	-	20	2731	c.2452G>A	c.(2452-2454)GCA>ACA	p.A818T	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	818						extracellular region	calcium ion binding			ovary(1)	1						TGAGCTCCTGCCGGGCTTGTA	0.602			NA											9	40					0	0	0.004482	0	0
DDB1	1642	broad.mit.edu	37	11	61084039	61084039	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:61084039C>A	uc001nrc.3	-	11	1452	c.1226G>T	c.(1225-1227)GGA>GTA	p.G409V	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.G409V|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Missense_Mutation_p.G409V	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	409	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						TGGCCATAATCCTGGAACAAG	0.438			NA						NER					24	105					2.21704e-12	3.96568e-12	0.00278	1	0
CCDC88B	283234	broad.mit.edu	37	11	64111737	64111737	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:64111737C>G	uc001nzy.2	+	14	1768	c.1724C>G	c.(1723-1725)TCC>TGC	p.S575C	CCDC88B_uc009ypo.1_Missense_Mutation_p.S572C|CCDC88B_uc001nzz.1_Missense_Mutation_p.S224C	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	575					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						TCAGACTGGTCCCCGCAAGAG	0.642			NA											4	44					0	0	0.000248	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68682307	68682307	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:68682307C>T	uc001ook.1	+	6	830	c.728C>T	c.(727-729)CCC>CTC	p.P243L	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	243					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGCTGCGCCCCCTCCAACATC	0.532			NA											8	74					0	0	0.004482	0	0
PAK1	5058	broad.mit.edu	37	11	77051741	77051741	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:77051741C>A	uc001oyh.3	-	11	1599	c.1066G>T	c.(1066-1068)GTG>TTG	p.V356L	PAK1_uc010rso.1_Missense_Mutation_p.V258L|PAK1_uc001oyg.3_Missense_Mutation_p.V356L|PAK1_uc001oyi.1_Missense_Mutation_p.V356L|PAK1_uc010rsn.1_Missense_Mutation_p.V69L	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	356	Protein kinase.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					GTTTCTGTCACCACATCTGTC	0.507			NA											40	240					5.44703e-19	1.04814e-18	0.002222	1	0
CASP5	838	broad.mit.edu	37	11	104874001	104874001	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:104874001C>A	uc010rva.1	-	4	575	c.543G>T	c.(541-543)GAG>GAT	p.E181D	CASP5_uc010ruz.1_Missense_Mutation_p.E194D|CASP5_uc010rvb.1_Missense_Mutation_p.E123D|CASP5_uc010rvc.1_Missense_Mutation_p.E39D|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	181					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AGCACAGCACCTCATCATGAT	0.333			NA											7	104					8.12818e-05	0.000103228	0.001984	1	0
SIK2	23235	broad.mit.edu	37	11	111573994	111573994	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr11:111573994C>G	uc001plt.2	+	7	913	c.795C>G	c.(793-795)ATC>ATG	p.I265M		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	265	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						TAGCCCAAATCAAGGAGCATA	0.443			NA											11	56					0	0	0.008291	0	0
GALNT8	26290	broad.mit.edu	37	12	4835766	4835766	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:4835766G>A	uc001qne.1	+	2	372	c.280G>A	c.(280-282)GAA>AAA	p.E94K		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	94	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GGCGAAAGATGAAGTACGCCC	0.443	Colon(108;631 1558 7270 20097 39846)		NA											5	34					0	0	0.000602	0	0
GALNT8	26290	broad.mit.edu	37	12	4848400	4848400	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:4848400T>A	uc001qne.1	+	3	673	c.581T>A	c.(580-582)CTG>CAG	p.L194Q		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	194	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AATGAAGCTCTGTCCATTATA	0.418	Colon(108;631 1558 7270 20097 39846)		NA											3	87					0	0	0.004672	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966757	41966757	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:41966757G>T	uc010skn.1	+	10	1647	c.1579G>T	c.(1579-1581)GAG>TAG	p.E527*	PDZRN4_uc001rmq.3_Nonsense_Mutation_p.E468*|PDZRN4_uc009zjz.2_Nonsense_Mutation_p.E466*|PDZRN4_uc001rmr.2_Nonsense_Mutation_p.E353*	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	726							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGACATCATGGAGCATCCAGA	0.473			NA											13	134					1.02788e-11	1.80472e-11	0.00499	1	0
DNAJC14	85406	broad.mit.edu	37	12	56221779	56221779	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:56221779G>A	uc001shx.1	-	2	868	c.664C>T	c.(664-666)CGG>TGG	p.R222W	DNAJC14_uc001shu.1_Missense_Mutation_p.R222W|DNAJC14_uc009zob.1_Missense_Mutation_p.R222W|DNAJC14_uc001shy.1_Missense_Mutation_p.R222W	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	222					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CGACCCAGCCGATGTCGACCA	0.597			NA											4	55					0	0	0.000248	0	0
NAV3	89795	broad.mit.edu	37	12	78225279	78225279	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:78225279C>A	uc001syp.2	+	1	211	c.38C>A	c.(37-39)CCA>CAA	p.P13Q	NAV3_uc001syo.2_Missense_Mutation_p.P13Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	13						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGAGGCAGCCAGCTGTTGGG	0.458			NA								HNSCC(70;0.22)			52	223					6.03219e-31	1.18467e-30	0.00361	1	0
EPYC	1833	broad.mit.edu	37	12	91372012	91372013	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:91372012_91372013CT>AA	uc001tbk.2	-	3	285_286	c.192_193AG>TT	c.(190-195)TCAGGG>TCTTGG	p.G65W		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	65					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						TCTCTGTTCCCTGAAGGCATCA	0.475			NA									OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	74					0	0	0.004672	0	0
ANO4	121601	broad.mit.edu	37	12	101510519	101510519	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:101510519G>A	uc010svm.1	+	25	3085	c.2513G>A	c.(2512-2514)CGA>CAA	p.R838Q	ANO4_uc001thw.2_Missense_Mutation_p.R803Q|ANO4_uc001thx.2_Missense_Mutation_p.R838Q|ANO4_uc001thy.2_Missense_Mutation_p.R358Q	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	838	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTTGAGAACCGATCTGAGCCT	0.507			NA								HNSCC(74;0.22)			5	145					0	0	0.000602	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686090	108686090	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:108686090T>A	uc009zuw.2	-	3	841	c.650A>T	c.(649-651)CAC>CTC	p.H217L	CMKLR1_uc001tmw.2_Missense_Mutation_p.H217L|CMKLR1_uc001tmv.2_Missense_Mutation_p.H215L|CMKLR1_uc009zuv.2_Missense_Mutation_p.H217L	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	217	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						CACCACCATGTGCCGGCTATA	0.562			NA											3	38					0	0	0.004672	0	0
PIWIL1	9271	broad.mit.edu	37	12	130830955	130830955	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:130830955C>A	uc001uik.2	+	5	447	c.357C>A	c.(355-357)TTC>TTA	p.F119L	PIWIL1_uc001uij.1_Missense_Mutation_p.F119L	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	119					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CTAACCATTTCCGGCTGACAT	0.393			NA											12	39					3.07112e-06	4.39886e-06	0.000978	1	0
C13orf33	84935	broad.mit.edu	37	13	31498491	31498491	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr13:31498491A>T	uc001uth.3	+	5	1172	c.831A>T	c.(829-831)TCA>TCT	p.S277S	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	277											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		CACCCAGATCATCTCTGACAG	0.363			NA											21	103					0	0	0.008871	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21762860	21762860	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr14:21762860C>T	uc001wag.2	+	2	110	c.110C>T	c.(109-111)CCC>CTC	p.P37L		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	37					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		ACTCAACCACCCTTGAGCAGG	0.418			NA											9	55					0	0	0.008291	0	0
RABGGTA	5875	broad.mit.edu	37	14	24735687	24735687	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr14:24735687C>A	uc001wof.2	-	15	1926	c.1504G>T	c.(1504-1506)GAC>TAC	p.D502Y	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.D502Y|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	502	LRR 3.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		GTGACGCCGTCCAGGGACTCT	0.607			NA											9	75					0.000442599	0.00055108	0.006214	1	0
ADCY4	196883	broad.mit.edu	37	14	24788542	24788542	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr14:24788542G>T	uc001wov.2	-	22	2840	c.2834C>A	c.(2833-2835)GCA>GAA	p.A945E	ADCY4_uc001wow.2_Missense_Mutation_p.A945E|ADCY4_uc010toh.1_Missense_Mutation_p.A631E|ADCY4_uc001wox.2_Missense_Mutation_p.A945E|ADCY4_uc001woy.2_Missense_Mutation_p.A945E	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	945	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		TACCTGTTGTGCATCCTGTCC	0.552			NA											12	68					1.5842e-08	2.6129e-08	0.001855	1	0
ADCY4	196883	broad.mit.edu	37	14	24793584	24793584	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr14:24793584C>A	uc001wov.2	-	15	1843	c.1837G>T	c.(1837-1839)GCC>TCC	p.A613S	ADCY4_uc001wow.2_Missense_Mutation_p.A613S|ADCY4_uc010toh.1_Missense_Mutation_p.A299S|ADCY4_uc001wox.2_Missense_Mutation_p.A613S|ADCY4_uc001woy.2_Missense_Mutation_p.A613S	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	613	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		TACGTGATGGCCAGAGCTGGG	0.557			NA											6	33					0.00116845	0.00142685	0.001168	1	0
SLC35F4	341880	broad.mit.edu	37	14	58048020	58048020	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr14:58048020G>T	uc001xdb.1	-	4	827	c.827C>A	c.(826-828)ACG>AAG	p.T276K	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.T117K	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GGAGACATCCGTGGCCGTCAG	0.428			NA											12	32					1.08611e-07	1.70291e-07	0.000978	1	0
OR4N3P	390539	broad.mit.edu	37	15	22413843	22413843	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:22413843C>T	uc001yuf.2	+	1	142	c.142C>T	c.(142-144)CTG>TTG	p.L48L		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						CACCATCTGCCTGCCTCTGCA	0.507			NA											18	498					0	0	0.008871	0	0
OCA2	4948	broad.mit.edu	37	15	28326847	28326847	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:28326847C>A	uc001zbh.3	-	2	284	c.174G>T	c.(172-174)CAG>CAT	p.Q58H	OCA2_uc010ayv.2_Missense_Mutation_p.Q58H	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	58	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CCCAAGAGCTCTGCCCGGCAG	0.597			NA							Oculocutaneous_Albinism				6	53					3.59834e-05	4.72747e-05	0.001168	1	0
TP53BP1	7158	broad.mit.edu	37	15	43748729	43748729	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:43748729G>A	uc001zrs.2	-	12	2210	c.2062C>T	c.(2062-2064)CCG>TCG	p.P688S	TP53BP1_uc010udp.1_Missense_Mutation_p.P688S|TP53BP1_uc001zrq.3_Missense_Mutation_p.P693S|TP53BP1_uc001zrr.3_Missense_Mutation_p.P693S|TP53BP1_uc010udq.1_Missense_Mutation_p.P693S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	688					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		AGGTGCAACGGAACACTCTCC	0.453			NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					11	132					0	0	0.001855	0	0
SLC24A5	283652	broad.mit.edu	37	15	48414087	48414087	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:48414087C>A	uc001zwe.2	+	2	228	c.155C>A	c.(154-156)TCG>TAG	p.S52*	SLC24A5_uc001zwd.2_Nonsense_Mutation_p.S52*|SLC24A5_uc010bel.2_Intron	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	52	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TCTCCATCATCGGAGTTTCCC	0.423			NA											6	117					3.59834e-05	4.72747e-05	0.001168	1	0
VPS13C	54832	broad.mit.edu	37	15	62302683	62302683	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:62302683C>A	uc002agz.2	-	13	1073	c.999G>T	c.(997-999)CTG>CTT	p.L333L	VPS13C_uc002aha.2_Silent_p.L290L|VPS13C_uc002ahb.1_Silent_p.L333L|VPS13C_uc002ahc.1_Silent_p.L290L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	333					protein localization					ovary(2)	2						GAGGTTTGGTCAGTTCAATGG	0.383			NA											7	104					0.00307968	0.00367824	0.00308	1	0
LCTL	197021	broad.mit.edu	37	15	66857164	66857164	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:66857164G>T	uc002aqc.2	-	2	264	c.132C>A	c.(130-132)GGC>GGA	p.G44G	LCTL_uc002aqd.3_Intron|LCTL_uc010bhw.2_5'UTR	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	44	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						AACTGCCCACGCCCCAGGAGA	0.662			NA											8	62					1.12685e-05	1.57264e-05	0.004482	1	0
AKAP13	11214	broad.mit.edu	37	15	86076960	86076960	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr15:86076960T>G	uc002blv.1	+	4	497	c.327T>G	c.(325-327)AAT>AAG	p.N109K	AKAP13_uc002bls.2_Missense_Mutation_p.N109K|AKAP13_uc002blt.1_Missense_Mutation_p.N109K|AKAP13_uc002blu.1_Missense_Mutation_p.N109K	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	109					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GTGCTGGAAATCAGCAGGCTT	0.498	Melanoma(94;603 1453 3280 32295 32951)		NA											5	106					0	0	0.000602	0	0
MEFV	4210	broad.mit.edu	37	16	3299593	3299593	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:3299593G>T	uc002cun.1	-	3	1138	c.1098C>A	c.(1096-1098)AGC>AGA	p.S366R		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	366					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GGGGGCTTAGGCTTCCCGGGC	0.647			NA											12	23					4.3838e-07	6.73479e-07	0.001855	1	0
PPL	5493	broad.mit.edu	37	16	4934298	4934298	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:4934298G>T	uc002cyd.1	-	22	4448	c.4358C>A	c.(4357-4359)CCG>CAG	p.P1453Q		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1453	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CGCCTGCTGCGGGTCCTGCTG	0.657			NA											15	106					0.000219431	0.000275919	0.00245	1	0
A2BP1	54715	broad.mit.edu	37	16	7760688	7760688	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:7760688C>A	uc002cys.2	+	16	2123	c.1135C>A	c.(1135-1137)CTT>ATT	p.L379I	A2BP1_uc002cyt.2_Missense_Mutation_p.L352I|A2BP1_uc010uyb.1_Missense_Mutation_p.L379I|A2BP1_uc002cyw.2_3'UTR|A2BP1_uc002cyy.2_Missense_Mutation_p.L400I|A2BP1_uc002cyx.2_Intron|A2BP1_uc010uyc.1_Missense_Mutation_p.L373I	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	379					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GGGTCTCGTTCTTTCTTCATT	0.423			NA											38	106					3.62531e-18	6.90621e-18	0.004289	1	0
ITGAM	3684	broad.mit.edu	37	16	31283276	31283276	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:31283276G>T	uc002ebq.2	+	7	765	c.667G>T	c.(667-669)GGG>TGG	p.G223W	ITGAM_uc002ebr.2_Missense_Mutation_p.G223W	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	223	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GCAGCTGCTTGGGCGGACACA	0.512			NA											10	117					3.86212e-05	5.02207e-05	0.008291	1	0
FHOD1	29109	broad.mit.edu	37	16	67265143	67265143	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:67265143G>C	uc002esl.2	-	17	2727	c.2615C>G	c.(2614-2616)CCT>CGT	p.P872R	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Missense_Mutation_p.P679R	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	872	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGAGGACTCAGGCCGGGTCTG	0.577			NA											13	39					0	0	0.001855	0	0
SNTB2	6645	broad.mit.edu	37	16	69279517	69279517	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr16:69279517G>A	uc002ewu.2	+	2	613	c.593G>A	c.(592-594)CGA>CAA	p.R198Q		NM_006750	NP_006741	Q13425	SNTB2_HUMAN	basic beta 2 syntrophin	198	PH 1.|PDZ.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		AAGTTCATCCGAGAAGTAACA	0.383	NSCLC(58;1458 1722 3262 39967)|Melanoma(111;1698 2173 25379 28738)		NA											6	211					0	0	0.004482	0	0
SPATA22	84690	broad.mit.edu	37	17	3352250	3352250	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:3352250G>A	uc002fvm.2	-	6	760	c.523C>T	c.(523-525)CTC>TTC	p.L175F	SPATA22_uc010vrg.1_Missense_Mutation_p.L159F|SPATA22_uc010vrf.1_Missense_Mutation_p.L175F|SPATA22_uc002fvn.2_Missense_Mutation_p.L175F|SPATA22_uc002fvo.2_Missense_Mutation_p.L175F|SPATA22_uc002fvp.2_Missense_Mutation_p.L175F|SPATA22_uc010ckf.2_Missense_Mutation_p.L132F	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	175											0						GTTTGTCTGAGTAGCTCGGTT	0.388			NA											8	261					0	0	0.004482	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594199	6594199	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:6594199C>A	uc002gdj.2	-	10	1424	c.1336G>T	c.(1336-1338)GCA>TCA	p.A446S	SLC13A5_uc010vtf.1_Missense_Mutation_p.A446S|SLC13A5_uc010clq.2_Missense_Mutation_p.A403S|SLC13A5_uc002gdk.2_Missense_Mutation_p.A429S	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	446	Helical; (Potential).					integral to membrane	citrate transmembrane transporter activity				0						GTGATGGCTGCCGGGGGCACT	0.562			NA											7	103					2.0095e-06	2.9334e-06	0.001984	1	0
MYH1	4619	broad.mit.edu	37	17	10419891	10419891	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:10419891C>A	uc002gmo.2	-	3	163	c.69G>T	c.(67-69)GAG>GAT	p.E23D	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	23	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CTTCAATTCGCTCCCTTTCAG	0.502			NA											28	130					1.16021e-09	1.97339e-09	0.007291	1	0
MAP2K3	5606	broad.mit.edu	37	17	21215469	21215469	+	Missense_Mutation	SNP	C	C	A	rs71371053		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:21215469C>A	uc002gys.2	+	10	1055	c.790C>A	c.(790-792)CTG>ATG	p.L264M	MAP2K3_uc002gyt.2_Missense_Mutation_p.L235M|MAP2K3_uc002gyu.2_Missense_Mutation_p.L235M	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	264	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GATGGCCATCCTGCGGTTCCC	0.682			NA											5	33					0.00198382	0.00237684	0.001984	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319630	21319630	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:21319630C>A	uc002gyv.1	+	3	1681	c.976C>A	c.(976-978)CGC>AGC	p.R326S		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	326	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GTGGGGTCACCGCTTTGAGCC	0.587			NA								Prostate(3;0.18)			6	179					0.00116845	0.00142685	0.001168	1	0
CCT6B	10693	broad.mit.edu	37	17	33259426	33259426	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:33259426C>A	uc002hig.2	-	11	1401	c.1307G>T	c.(1306-1308)GGA>GTA	p.G436V	CCT6B_uc010ctg.2_Missense_Mutation_p.G399V|CCT6B_uc010wcc.1_Missense_Mutation_p.G391V	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	436					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				AGCTTGGACTCCAAGACGAGC	0.408			NA											22	185					2.21704e-12	3.96568e-12	0.00278	1	0
GGNBP2	79893	broad.mit.edu	37	17	34937774	34937774	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:34937774A>T	uc002hnb.2	+	9	1270	c.1021A>T	c.(1021-1023)ATG>TTG	p.M341L	GGNBP2_uc002hna.2_Missense_Mutation_p.M341L|GGNBP2_uc002hnc.1_Missense_Mutation_p.M170L	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	341					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TTTATAATAGATGACCGTGGA	0.264			NA											10	61					0	0	0.008291	0	0
MRPL45	84311	broad.mit.edu	37	17	36455435	36455435	+	Splice_Site	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:36455435G>T	uc002hpy.2	+	3	514	c.362_splice	c.e3+1	p.S121_splice		NM_032351	NP_115727	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45 precursor						intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CACAAGTGTCGTAGGTGTCTG	0.408			NA											8	63					4.68919e-08	7.57026e-08	0.008291	1	0
KRT40	125115	broad.mit.edu	37	17	39138576	39138576	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:39138576T>A	uc010cxh.1	-	5	831	c.670A>T	c.(670-672)AAG>TAG	p.K224*	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	224	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				TGGTTTTTCTTAAGGCAAAGG	0.473			NA											11	96					0	0	0.000978	0	0
CCDC56	28958	broad.mit.edu	37	17	40948087	40948087	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:40948087C>T	uc010wgz.1	-	3	448	c.171G>A	c.(169-171)AGG>AGA	p.R57R	WNK4_uc002ibj.2_Intron|WNK4_uc010wgx.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank			Q9Y2R0	CCD56_HUMAN	SubName: Full=cDNA FLJ50764;	Error:Variant_position_missing_in_Q9Y2R0_after_alignment						integral to membrane					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0741)		GAGAGGAGAACCTGGGAGAGC	0.537			NA											4	93					0	0	0.000602	0	0
APPBP2	10513	broad.mit.edu	37	17	58541402	58541402	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:58541402C>T	uc002iys.1	-	6	1030	c.742G>A	c.(742-744)GTC>ATC	p.V248I	APPBP2_uc010ddl.1_Missense_Mutation_p.V177I	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	248					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TGTCTTAAGACATCCACCACA	0.294			NA											7	66					0	0	0.004482	0	0
KIF19	124602	broad.mit.edu	37	17	72338032	72338032	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:72338032C>A	uc002jkm.3	+	3	276	c.138C>A	c.(136-138)GAC>GAA	p.D46E	KIF19_uc002jkj.2_Missense_Mutation_p.D46E|KIF19_uc002jkk.2_Missense_Mutation_p.D46E|KIF19_uc002jkl.2_Missense_Mutation_p.D46E	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	46	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TTCTCATGGACCCAATGGAGG	0.622			NA											18	93					7.07596e-05	9.07724e-05	0.006122	1	0
C17orf70	80233	broad.mit.edu	37	17	79517597	79517597	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:79517597T>C	uc002kaq.2	-	3	978	c.923A>G	c.(922-924)CAC>CGC	p.H308R	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.H157R	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	308					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GCAGTCACAGTGCACATCCTC	0.607			NA											7	61					0	0	0.001984	0	0
DSG4	147409	broad.mit.edu	37	18	28980905	28980905	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:28980905C>G	uc002kwq.2	+	10	1474	c.1339C>G	c.(1339-1341)CAA>GAA	p.Q447E	DSG4_uc002kwr.2_Missense_Mutation_p.Q447E	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	447	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGGTGAGATACAATTTTCTAG	0.303			NA											3	81					0	0	0.004672	0	0
ZNF271	10778	broad.mit.edu	37	18	32887120	32887120	+	Missense_Mutation	SNP	G	G	T	rs142309584		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:32887120G>T	uc002kyq.3	+	3	1524	c.532G>T	c.(532-534)GTT>TTT	p.V178F	ZNF271_uc002kyp.3_Missense_Mutation_p.V178F|ZNF271_uc002kyr.3_Missense_Mutation_p.V178F	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						TTTAGTCGCCGTTCAGATCTT	0.378			NA											10	157					1.58986e-06	2.39422e-06	0.008291	1	0
SETBP1	26040	broad.mit.edu	37	18	42532822	42532822	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:42532822C>G	uc010dni.2	+	4	3813	c.3517C>G	c.(3517-3519)CTT>GTT	p.L1173V		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1173						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCTGAGTGGTCTTTTTGCAGG	0.542			NA							Schinzel-Giedion_syndrome				7	66					0	0	0.001984	0	0
SLC14A2	8170	broad.mit.edu	37	18	43262466	43262466	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:43262466G>T	uc010dnj.2	+	21	3066	c.2745G>T	c.(2743-2745)CAG>CAT	p.Q915H	SLC14A2_uc002lbe.2_Missense_Mutation_p.Q915H	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	915						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CAAAGTATCAGGCCTACGATG	0.498			NA											6	92					1.06961e-07	1.68398e-07	0.00308	1	0
MYO5B	4645	broad.mit.edu	37	18	47421485	47421485	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:47421485C>G	uc002leb.2	-	22	3159	c.2871G>C	c.(2869-2871)ATG>ATC	p.M957I	MYO5B_uc002lea.2_Missense_Mutation_p.M98I	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	957	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GCTCTACCTCCATGGTGTATG	0.547			NA											6	57					0	0	0.00308	0	0
CDH7	1005	broad.mit.edu	37	18	63492008	63492008	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:63492008G>T	uc002ljz.2	+	6	1247	c.922G>T	c.(922-924)GGC>TGC	p.G308C	CDH7_uc002lka.2_Missense_Mutation_p.G308C|CDH7_uc002lkb.2_Missense_Mutation_p.G308C	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	308	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TGATGGTTTGGGCATTTTTAA	0.368			NA											15	96					5.01169e-05	6.47273e-05	0.00499	1	0
NETO1	81832	broad.mit.edu	37	18	70417390	70417390	+	Nonsense_Mutation	SNP	G	G	T	rs139202022	by1000genomes	TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:70417390G>T	uc002lkw.2	-	9	1732	c.1448C>A	c.(1447-1449)TCG>TAG	p.S483*	NETO1_uc002lkx.1_Nonsense_Mutation_p.S482*|NETO1_uc002lky.1_Nonsense_Mutation_p.S483*	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	483	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGCATCTTGCGAGTAGCTGTG	0.502			NA											10	59					0.000442599	0.00055108	0.006214	1	0
SHC2	25759	broad.mit.edu	37	19	425152	425152	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:425152C>A	uc002loq.3	-	10	1254	c.1254G>T	c.(1252-1254)CAG>CAT	p.Q418H	SHC2_uc002lop.3_Missense_Mutation_p.Q159H	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	418	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTCCAGACCCTGGGTGTTGA	0.682			NA											12	47					1.61879e-10	2.80345e-10	0.001368	1	0
SLC25A41	284427	broad.mit.edu	37	19	6427222	6427222	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:6427222C>T	uc010dus.2	-	6	918	c.832G>A	c.(832-834)GGG>AGG	p.G278R	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Missense_Mutation_p.G140R	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	278					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						CTGGGGTCCCCCATATCCCTG	0.627			NA											6	25					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9066578	9066578	+	Silent	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:9066578G>C	uc002mkp.2	-	3	21072	c.20868C>G	c.(20866-20868)ACC>ACG	p.T6956T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6958	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAAATGCTGGTCTCTCTCA	0.448			NA											20	175					0	0	0.008871	0	0
ZNF317	57693	broad.mit.edu	37	19	9270789	9270789	+	Splice_Site	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:9270789G>A	uc002mku.2	+	7	744	c.469_splice	c.e7-1	p.E157_splice	ZNF317_uc002mkv.2_Splice_Site_p.E16_splice|ZNF317_uc002mkw.2_Splice_Site_p.E125_splice|ZNF317_uc002mkx.2_Splice_Site_p.E72_splice|ZNF317_uc002mky.2_Splice_Site_p.E40_splice	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTAACCAACAGGAAAGAGCCG	0.478			NA											5	74					0	0	0.000602	0	0
JAK3	3718	broad.mit.edu	37	19	17942109	17942109	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:17942109C>A	uc002nhn.3	-	21	3006	c.2906G>T	c.(2905-2907)GGC>GTC	p.G969V	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.G969V	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	969	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CTTAGCTAGGCCGAAGTCAGC	0.622			2	Mis		acute megakaryocytic leukemia|								11	98					0.00136819	0.00166013	0.001368	1	0
ZNF536	9745	broad.mit.edu	37	19	30936068	30936068	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:30936068G>T	uc002nsu.1	+	2	1737	c.1599G>T	c.(1597-1599)ATG>ATT	p.M533I	ZNF536_uc010edd.1_Missense_Mutation_p.M533I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCATGGCCATGGAACATGGCT	0.602			NA											6	80					3.59834e-05	4.72747e-05	0.001168	1	0
WDR62	284403	broad.mit.edu	37	19	36580003	36580003	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:36580003A>T	uc002odc.2	+	14	1923	c.1832A>T	c.(1831-1833)CAG>CTG	p.Q611L	WDR62_uc002odd.2_Missense_Mutation_p.Q611L	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	611	WD 9.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CGCAGTGCCCAGCAGGTAGGG	0.622			NA											7	21					0	0	0.001984	0	0
ZNF260	339324	broad.mit.edu	37	19	37005826	37005826	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:37005826G>A	uc002oee.1	-	4	1159	c.315C>T	c.(313-315)CAC>CAT	p.H105H	ZNF260_uc002oed.1_Silent_p.H102H|ZNF260_uc010eey.1_Silent_p.H102H|ZNF260_uc002oef.1_Silent_p.H102H	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	105	C2H2-type 3.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TCTCTCCAGTGTGATGTTTCT	0.378			NA											10	148					0	0	0.008291	0	0
RELB	5971	broad.mit.edu	37	19	45541024	45541024	+	Silent	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:45541024A>G	uc002paj.1	+	13	1842	c.1716A>G	c.(1714-1716)CTA>CTG	p.L572L	SFRS16_uc002pak.2_5'Flank|SFRS16_uc002pal.2_5'Flank|SFRS16_uc010xxh.1_5'Flank|SFRS16_uc002pam.2_5'Flank|SFRS16_uc002pan.1_5'Flank	NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	572						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GCGGCCTCCTATCCCCGGGGC	0.687			NA											6	41					0	0	0.001984	0	0
SLC6A16	28968	broad.mit.edu	37	19	49813408	49813408	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:49813408C>A	uc002pmz.2	-	4	823	c.589G>T	c.(589-591)GGC>TGC	p.G197C	SLC6A16_uc002pna.2_Missense_Mutation_p.G197C|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	197	Helical; Name=2; (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		AAGTACAGGCCGAGGATGAAG	0.522			NA											19	63					7.45023e-12	1.32025e-11	0.001523	1	0
NUP62	23636	broad.mit.edu	37	19	50413058	50413058	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:50413058C>A	uc002pqx.2	-	2	111	c.7G>T	c.(7-9)GGG>TGG	p.G3W	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.G3W|NUP62_uc002pqz.2_Missense_Mutation_p.G3W|NUP62_uc002pra.2_Missense_Mutation_p.G3W|NUP62_uc002prb.2_Missense_Mutation_p.G3W|NUP62_uc002prc.2_Missense_Mutation_p.G3W	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	3	15 X 9 AA approximate repeats.|1.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AAATTAAACCCGCTCATGGCT	0.557			NA											6	25					2.0095e-06	2.9334e-06	0.001984	1	0
ZNF836	162962	broad.mit.edu	37	19	52658445	52658445	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:52658445C>A	uc010ydi.1	-	5	2865	c.2491G>T	c.(2491-2493)GAC>TAC	p.D831Y	ZNF836_uc010ydj.1_Missense_Mutation_p.D831Y	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	831					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGGTTTGTCCCCAGTATGC	0.388			NA											30	241					7.26314e-15	1.34988e-14	0.007291	1	0
FCAR	2204	broad.mit.edu	37	19	55385779	55385779	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:55385779G>A	uc002qhr.1	+	1	231	c.34G>A	c.(34-36)GTG>ATG	p.V12M	FCAR_uc002qhq.2_Missense_Mutation_p.V12M|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Translation_Start_Site|FCAR_uc010esi.1_5'UTR|FCAR_uc002qhu.1_Missense_Mutation_p.V12M|FCAR_uc002qhv.1_Missense_Mutation_p.V12M|FCAR_uc002qhw.1_Missense_Mutation_p.G12R|FCAR_uc002qhx.1_Missense_Mutation_p.G12R|FCAR_uc002qhy.1_Missense_Mutation_p.G12R|FCAR_uc002qhz.1_Missense_Mutation_p.G12R|FCAR_uc002qia.1_Missense_Mutation_p.G12S	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	12					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CCTGTGTCTTGGTGAGTTTCA	0.478			NA											11	80					0	0	0.000978	0	0
NLRP13	126204	broad.mit.edu	37	19	56443652	56443652	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:56443652G>T	uc010ygg.1	-	1	51	c.26C>A	c.(25-27)CCC>CAC	p.P9H		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	9	DAPIN.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACCACCGTTGGGGCAGGTGAT	0.498			NA											4	71					1.23904e-05	1.71041e-05	0.000602	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701419	56701419	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:56701419T>A	uc010ygh.1	-	4	1265	c.1265A>T	c.(1264-1266)CAC>CTC	p.H422L		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	422	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTGGACTCGTGGGCGAACCG	0.567			NA											4	67					0	0	0.000248	0	0
ZNF772	400720	broad.mit.edu	37	19	57985662	57985662	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr19:57985662G>T	uc002qot.2	-	5	711	c.450C>A	c.(448-450)GGC>GGA	p.G150G	ZNF547_uc002qpm.3_Intron|ZNF772_uc010ygy.1_Silent_p.G109G|ZNF772_uc010ygz.1_Silent_p.G38G|ZNF772_uc010yha.1_Silent_p.G96G|ZNF772_uc002qou.2_Silent_p.G38G	NM_001024596	NP_001019767	Q68DY9	ZN772_HUMAN	zinc finger protein 772 isoform 1	150	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)|Lung(386;0.174)		TTAAGACCAGGCCACATGTCC	0.483	Melanoma(5;289 436 14293 15924 30817)		NA											8	95					0.000274275	0.000343746	0.004482	1	0
GREB1	9687	broad.mit.edu	37	2	11718443	11718443	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:11718443C>A	uc002rbk.1	+	6	958	c.658C>A	c.(658-660)CCC>ACC	p.P220T	GREB1_uc002rbl.2_Missense_Mutation_p.P220T|GREB1_uc002rbm.2_Missense_Mutation_p.P110T|GREB1_uc002rbn.1_Missense_Mutation_p.P220T	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	220						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCGGCAGATCCCCGCCAGTAC	0.582	Ovarian(39;850 945 2785 23371 33093)		NA											37	159					1.13552e-05	1.57895e-05	0.002222	1	0
GREB1	9687	broad.mit.edu	37	2	11755257	11755257	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:11755257T>A	uc002rbk.1	+	20	3463	c.3163T>A	c.(3163-3165)TGC>AGC	p.C1055S	GREB1_uc002rbp.1_Missense_Mutation_p.C53S	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1055						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AAACTCCTCCTGCTTGGTGAG	0.542	Ovarian(39;850 945 2785 23371 33093)		NA											4	61					0	0	0.000602	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656903	40656903	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:40656903C>A	uc002rrx.2	-	1	542	c.518G>T	c.(517-519)GGA>GTA	p.G173V	SLC8A1_uc002rry.2_Missense_Mutation_p.G173V|SLC8A1_uc002rrz.2_Missense_Mutation_p.G173V|SLC8A1_uc002rsa.2_Missense_Mutation_p.G173V|SLC8A1_uc002rsd.3_Missense_Mutation_p.G173V|SLC8A1_uc002rsb.1_Missense_Mutation_p.G173V|SLC8A1_uc010fan.1_Missense_Mutation_p.G173V|SLC8A1_uc002rsc.1_Missense_Mutation_p.G173V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	173	Alpha-1.|Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGCAGCACTTCCCACGATGGT	0.468			NA											6	43					2.0095e-06	2.9334e-06	0.001984	1	0
PSME4	23198	broad.mit.edu	37	2	54122797	54122797	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:54122797A>T	uc002rxp.2	-	33	3821	c.3765T>A	c.(3763-3765)ACT>ACA	p.T1255T	PSME4_uc010yop.1_Silent_p.T1141T|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.T630T|PSME4_uc010fbv.1_Silent_p.T399T	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1255					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTCTTGGTATAGTTTTGCTGT	0.403			NA											11	195					0	0	0.000978	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69053120	69053120	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:69053120C>A	uc002seu.2	+	11	2096	c.1732C>A	c.(1732-1734)CTT>ATT	p.L578I	ARHGAP25_uc010fdg.2_Missense_Mutation_p.L579I|ARHGAP25_uc010yql.1_Missense_Mutation_p.L539I|ARHGAP25_uc002sew.2_Missense_Mutation_p.L571I|ARHGAP25_uc002sex.2_Missense_Mutation_p.L572I|ARHGAP25_uc002sey.2_Missense_Mutation_p.L305I	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	578	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TCCTTGTAGCCTTGAGAAGGA	0.443			NA											7	46					2.7689e-08	4.48915e-08	0.001984	1	0
ACTG2	72	broad.mit.edu	37	2	74129498	74129499	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:74129498_74129499GG>TT	uc002sjw.2	+	3	260_261	c.138_139GG>TT	c.(136-141)GTGGGA>GTTTGA	p.G47*	ACTG2_uc010fex.1_Nonsense_Mutation_p.G47*|ACTG2_uc010fey.2_Nonsense_Mutation_p.G47*|ACTG2_uc010yrn.1_Intron	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	47					muscle contraction	cytoskeleton|cytosol	ATP binding				0						GTGTGATGGTGGGAATGGGCCA	0.5			NA											5	56					0	0	0.004672	0	0
REG1A	5967	broad.mit.edu	37	2	79349965	79349965	+	Splice_Site	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:79349965A>G	uc002snz.2	+	5	425	c.322_splice	c.e5-2	p.N108_splice	REG1A_uc010ysd.1_Splice_Site_p.N108_splice	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor						positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TTCCCCATCTAGAACCGCCGC	0.547			NA											11	129					0	0	0.000978	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518100	84518100	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:84518100G>A	uc010ffz.1	+	1	295	c.158G>A	c.(157-159)GGT>GAT	p.G53D		NR_003663				RecName: Full=FUN14 domain-containing protein 2; AltName: Full=Hepatitis C virus core-binding protein 6; AltName: Full=Cervical cancer proto-oncogene 3 protein;          Short=HCC-3;												0						TTCATTGGAGGTGTCACTGGA	0.502			NA											8	141					0	0	0.008291	0	0
ZRANB3	84083	broad.mit.edu	37	2	135988469	135988469	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:135988469C>G	uc002tum.2	-	13	1685	c.1568G>C	c.(1567-1569)CGA>CCA	p.R523P	ZRANB3_uc002tuk.2_Missense_Mutation_p.R66P|ZRANB3_uc002tul.2_Missense_Mutation_p.R523P	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	523						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		AAAAAATGATCGAATATCATG	0.348			NA											6	98					0	0	0.001168	0	0
ABCB11	8647	broad.mit.edu	37	2	169869807	169869807	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:169869807T>C	uc002ueo.1	-	5	490	c.364A>G	c.(364-366)AAC>GAC	p.N122D		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	122	ABC transmembrane type-1 1.|Extracellular (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TTTGTCATGTTCTGGTTGAGG	0.343			NA											89	280					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179395805	179395805	+	Silent	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:179395805G>C	uc010zfg.1	-	307	98057	c.97833C>G	c.(97831-97833)ACC>ACG	p.T32611T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T26306T|TTN_uc010zfi.1_Silent_p.T26239T|TTN_uc010zfj.1_Silent_p.T26114T|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33538							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTACTTTGTGGTGGTCACTT	0.498			NA											18	380					0	0	0.006122	0	0
TTN	7273	broad.mit.edu	37	2	179428039	179428039	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:179428039A>C	uc010zfg.1	-	275	75340	c.75116T>G	c.(75115-75117)GTA>GGA	p.V25039G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V18734G|TTN_uc010zfi.1_Missense_Mutation_p.V18667G|TTN_uc010zfj.1_Missense_Mutation_p.V18542G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25966							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACCTCTACAACATAGCC	0.468			NA											3	91					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179575972	179575972	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:179575972A>C	uc010zfg.1	-	94	24483	c.24259T>G	c.(24259-24261)TCC>GCC	p.S8087A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S4748A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9014							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGACACGGAGATAGGTTCT	0.378			NA											59	223					0	0	0.00361	0	0
COL3A1	1281	broad.mit.edu	37	2	189839273	189839273	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:189839273A>G	uc002uqj.1	+	1	175	c.58A>G	c.(58-60)ATT>GTT	p.I20V		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	20					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TCATCCCACTATTATTTTGGC	0.413			NA											7	107					0	0	0.001984	0	0
COL5A2	1290	broad.mit.edu	37	2	189904155	189904155	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:189904155C>A	uc002uqk.2	-	51	4043	c.3768G>T	c.(3766-3768)GCG>GCT	p.A1256A	COL5A2_uc010frx.2_Silent_p.A832A	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1256					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CATCAGGAGCCGCCTGATCTT	0.527			NA											9	49					7.48243e-07	1.13127e-06	0.006214	1	0
PMS1	5378	broad.mit.edu	37	2	190660540	190660540	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:190660540G>T	uc002urh.3	+	3	707	c.178G>T	c.(178-180)GGT>TGT	p.G60C	PMS1_uc010zga.1_Missense_Mutation_p.G60C|PMS1_uc010zgb.1_Intron|PMS1_uc002urk.3_Missense_Mutation_p.G60C|PMS1_uc002uri.3_Missense_Mutation_p.G60C|PMS1_uc010zgc.1_5'UTR|PMS1_uc010zgd.1_Intron|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.G60C|PMS1_uc010frz.2_Missense_Mutation_p.G60C|PMS1_uc010zfz.1_Missense_Mutation_p.G60C	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	60					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TAACGGGGAGGGTATCAAGGC	0.328			NA	Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					7	72					2.0095e-06	2.9334e-06	0.001984	1	0
DNAH7	56171	broad.mit.edu	37	2	196718111	196718111	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:196718111C>A	uc002utj.3	-	46	8838	c.8737G>T	c.(8737-8739)GGA>TGA	p.G2913*		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2913					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCAACCACTCCGGAGGAAATG	0.512			NA											22	69					7.41877e-09	1.22894e-08	0.001882	1	0
RFTN2	130132	broad.mit.edu	37	2	198436886	198436886	+	Missense_Mutation	SNP	C	C	G	rs115896530	by1000genomes	TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:198436886C>G	uc002uuo.3	-	9	1754	c.1352G>C	c.(1351-1353)CGC>CCC	p.R451P		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	451						plasma membrane					0						GGGAGAAAGGCGGCACTCCTC	0.527			NA											5	111					0	0	0.001168	0	0
EEF1B2	1933	broad.mit.edu	37	2	207026077	207026077	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:207026077G>T	uc002vbf.1	+	4	369	c.211G>T	c.(211-213)GGA>TGA	p.G71*	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Nonsense_Mutation_p.G71*|EEF1B2_uc002vbh.1_Nonsense_Mutation_p.G71*|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	71	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						AAGCCTGCCAGGAGTGAAGAA	0.373			NA											9	106					1.11149e-13	2.05572e-13	0.008291	1	0
EEF1B2	1933	broad.mit.edu	37	2	207026150	207026150	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:207026150G>C	uc002vbf.1	+	4	442	c.284G>C	c.(283-285)AGT>ACT	p.S95T	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Missense_Mutation_p.S95T|EEF1B2_uc002vbh.1_Missense_Mutation_p.S95T|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	95						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						GCTACAGATAGTAAAGATGAT	0.363			NA											11	133					0	0	0.000978	0	0
ATIC	471	broad.mit.edu	37	2	216214301	216214301	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:216214301G>T	uc002vex.3	+	16	1876	c.1702G>T	c.(1702-1704)GAC>TAC	p.D568Y	ATIC_uc010zjo.1_Missense_Mutation_p.D509Y|ATIC_uc002vey.3_Missense_Mutation_p.D567Y	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	568					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	TTCTGCTGCTGACAAAGTTGT	0.473			NA	T	ALK	ALCL								5	111					1.024e-07	1.6324e-07	0.000602	1	0
DNPEP	23549	broad.mit.edu	37	2	220246787	220246787	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:220246787G>A	uc010zlg.1	-	11	1117	c.1035C>T	c.(1033-1035)TGC>TGT	p.C345C	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Silent_p.C337C|DNPEP_uc002vlf.1_Silent_p.C323C|DNPEP_uc002vlh.2_Silent_p.C284C|DNPEP_uc002vli.1_Silent_p.C284C	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	327					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	TCGGGTGCTGGCACGAGGCTG	0.592			NA											3	32					0	0	0.004672	0	0
SPEG	10290	broad.mit.edu	37	2	220354583	220354583	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr2:220354583G>C	uc010fwg.2	+	36	8843	c.8843G>C	c.(8842-8844)AGC>ACC	p.S2948T		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2948	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGTCCCCGAAGCTCTCCCAGG	0.657			NA											3	43					0	0	0.004672	0	0
SNRPB	6628	broad.mit.edu	37	20	2446399	2446399	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr20:2446399C>A	uc002wfz.1	-	3	385	c.222G>T	c.(220-222)GGG>GGT	p.G74G	SNRPB_uc002wga.1_Silent_p.G74G|SNRPB_uc010zpv.1_5'UTR|SNRPB_uc002wgb.2_Silent_p.G74G|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	74					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						CCAGATTCTCCCCTCGCAGCA	0.468			NA											6	71					5.9392e-07	9.05134e-07	0.001168	1	0
PLCB1	23236	broad.mit.edu	37	20	8717720	8717720	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr20:8717720G>T	uc002wnb.2	+	20	2092	c.2089G>T	c.(2089-2091)GTG>TTG	p.V697L	PLCB1_uc010zrb.1_Missense_Mutation_p.V596L|PLCB1_uc002wna.2_Missense_Mutation_p.V697L|PLCB1_uc002wnc.1_Missense_Mutation_p.V596L|PLCB1_uc002wnd.1_Missense_Mutation_p.V274L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	697	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGGGACTTACGTGGAAGTAGA	0.358			NA											10	86					3.86212e-05	5.02207e-05	0.008291	1	0
CEP250	11190	broad.mit.edu	37	20	34091626	34091626	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr20:34091626G>C	uc002xcm.2	+	31	6100	c.5429G>C	c.(5428-5430)AGA>ACA	p.R1810T	CEP250_uc010zve.1_Missense_Mutation_p.R1178T	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1810	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAGGCCCAGAGAGCCCTAGCC	0.597			NA											10	44					0	0	0.006214	0	0
RALGAPB	57148	broad.mit.edu	37	20	37177415	37177415	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr20:37177415A>T	uc002xiw.2	+	20	3243	c.2986A>T	c.(2986-2988)AGA>TGA	p.R996*	RALGAPB_uc002xix.2_Nonsense_Mutation_p.R992*|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Nonsense_Mutation_p.R774*	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	996					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TCTTTTACCCAGAGGAGCAAA	0.408			NA											5	100					0	0	0.001168	0	0
C20orf20	55257	broad.mit.edu	37	20	61430905	61430905	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr20:61430905C>G	uc002ydi.2	+	5	596	c.525C>G	c.(523-525)GAC>GAG	p.D175E		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	175					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					AAGGCGCAGACAAGCGGAAGC	0.552			NA											4	84					0	0	0.000248	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											8	22					0	0	0.006214	0	0
PCBP3	54039	broad.mit.edu	37	21	47359949	47359949	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr21:47359949A>T	uc002zhq.1	+	13	1040	c.915A>T	c.(913-915)ATA>ATT	p.I305I	PCBP3_uc002zhp.1_Silent_p.I285I|PCBP3_uc002zhs.1_Silent_p.I279I|PCBP3_uc002zhr.1_Silent_p.I304I|PCBP3_uc002zht.1_Silent_p.I295I	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	305	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TCTAGCTAATAGGCTGCATAA	0.567			NA											5	77					0	0	0.000602	0	0
MICAL3	57553	broad.mit.edu	37	22	18387502	18387502	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr22:18387502C>T	uc002zng.3	-	3	721	c.368G>A	c.(367-369)CGC>CAC	p.R123H	MICAL3_uc011agl.1_Missense_Mutation_p.R123H|MICAL3_uc002znh.2_Missense_Mutation_p.R123H|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Missense_Mutation_p.R123H|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.R123H|MICAL3_uc011agm.1_Missense_Mutation_p.R123H	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	123						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		GACGTTGTTGCGGGAGAAGGC	0.527			NA											26	152					0	0	0.00632	0	0
PEX26	55670	broad.mit.edu	37	22	18562679	18562679	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr22:18562679C>A	uc002znp.3	+	3	479	c.270C>A	c.(268-270)ATC>ATA	p.I90I	TUBA8_uc002znr.2_5'UTR|PEX26_uc002znq.3_Silent_p.I90I|uc002zns.2_5'Flank|PEX26_uc002znt.2_Silent_p.I90I	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	90	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TTGTGGGGATCCAGGCCCTGG	0.527			NA											23	104					2.39556e-15	4.51837e-15	0.00278	1	0
TBX1	6899	broad.mit.edu	37	22	19752613	19752613	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr22:19752613G>T	uc002zqb.2	+	6	946	c.817G>T	c.(817-819)GTC>TTC	p.V273F	TBX1_uc002zqa.1_Missense_Mutation_p.V273F|TBX1_uc002zqc.2_Missense_Mutation_p.V273F	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	273	T-box.				embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				ATTCACCGCGGTCACTGCCTA	0.547			NA											4	52					8.12818e-05	0.000103228	0.001984	1	0
NEFH	4744	broad.mit.edu	37	22	29885226	29885226	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr22:29885226C>G	uc003afo.2	+	4	1668	c.1597C>G	c.(1597-1599)CCA>GCA	p.P533A	NEFH_uc003afp.2_5'Flank	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	533	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.|2.				cell death|nervous system development	neurofilament					0						GGCCAAGTCCCCAGAGAAGGA	0.552			NA											4	44					0	0	0.000248	0	0
MYH9	4627	broad.mit.edu	37	22	36684363	36684364	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr22:36684363_36684364CC>AA	uc003apg.2	-	34	5097_5098	c.4866_4867GG>TT	c.(4864-4869)CTGGAG>CTTTAG	p.E1623*		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1623	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						ATGTGCGCCTCCAGGTCCTTCA	0.658			NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				9	74					0	0	0.004672	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706497	21706497	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:21706497G>T	uc003cce.2	-	2	454	c.46C>A	c.(46-48)CTC>ATC	p.L16I	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	16						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						AGGGCCGGGAGAGCAGGACTC	0.512			NA											8	24					1.76689e-08	2.88921e-08	0.006214	1	0
ARPP21	10777	broad.mit.edu	37	3	35833950	35833950	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:35833950C>A	uc003cgb.2	+	19	2373	c.2109C>A	c.(2107-2109)AAC>AAA	p.N703K	ARPP21_uc003cga.2_Missense_Mutation_p.N684K|ARPP21_uc011axy.1_Missense_Mutation_p.N704K|ARPP21_uc003cgf.2_Missense_Mutation_p.N539K|ARPP21_uc003cgg.2_Missense_Mutation_p.N226K	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	703	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGAGTCAGAACGTGATAAATA	0.463			NA											23	137					1.96895e-08	3.20585e-08	0.00278	1	0
SETD2	29072	broad.mit.edu	37	3	47158152	47158152	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:47158152C>A	uc003cqs.2	-	4	4600	c.4547G>T	c.(4546-4548)TGT>TTT	p.C1516F	SETD2_uc003cqv.2_Missense_Mutation_p.C1505F	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1516	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATCTTCCCCACATGCTATTTC	0.353			NA	N|F|S|Mis		clear cell renal carcinoma								16	119					2.23348e-06	3.24793e-06	0.004007	1	0
COL7A1	1294	broad.mit.edu	37	3	48617237	48617237	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:48617237C>A	uc003ctz.2	-	57	5136	c.5135G>T	c.(5134-5136)GGA>GTA	p.G1712V	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1712	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGCTCCAGGTCCTGTGTCTAC	0.582			NA											5	67					3.59834e-05	4.72747e-05	0.001168	1	0
PDZRN3	23024	broad.mit.edu	37	3	73651529	73651529	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:73651529C>A	uc003dpl.1	-	3	990	c.894G>T	c.(892-894)CTG>CTT	p.L298L		NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	298	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CATGAATTTGCAGGCCTCCTT	0.433			NA											14	243					6.31663e-08	1.01119e-07	0.003163	1	0
NSUN3	63899	broad.mit.edu	37	3	93813893	93813893	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:93813893C>T	uc003drl.1	+	5	754	c.638C>T	c.(637-639)CCG>CTG	p.P213L		NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	213							methyltransferase activity			skin(1)	1						GTGGATGCTCCGTGTTCAAAT	0.408			NA											9	140					0	0	0.004482	0	0
OR5K1	26339	broad.mit.edu	37	3	98188926	98188926	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:98188926G>T	uc003dsm.2	+	1	506	c.506G>T	c.(505-507)TGT>TTT	p.C169F		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTAGTTTTCTGTGGATCGAAT	0.398			NA											11	303					6.40141e-05	8.23965e-05	0.000978	1	0
MORC1	27136	broad.mit.edu	37	3	108698378	108698378	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:108698378G>T	uc003dxl.2	-	24	2548	c.2461C>A	c.(2461-2463)CTG>ATG	p.L821M	MORC1_uc011bhn.1_Missense_Mutation_p.L800M	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	821					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTAGACTTCAGTTTTCTCACT	0.403			NA											6	150					0.00198382	0.00237684	0.001984	1	0
MORC1	27136	broad.mit.edu	37	3	108819311	108819311	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:108819311C>A	uc003dxl.2	-	5	354	c.267G>T	c.(265-267)CGG>CGT	p.R89R	MORC1_uc011bhn.1_Silent_p.R89R	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	89					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AGGTTGACAGCCGTTTTTTGG	0.393			NA											11	121					2.80697e-09	4.67012e-09	0.000978	1	0
KIAA2018	205717	broad.mit.edu	37	3	113378249	113378249	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:113378249A>T	uc003eam.2	-	7	2691	c.2280T>A	c.(2278-2280)CCT>CCA	p.P760P	KIAA2018_uc003eal.2_Silent_p.P704P	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	760					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						CTGTTGTCACAGGAGGTGCTG	0.393			NA											7	80					0	0	0.001984	0	0
C3orf1	51300	broad.mit.edu	37	3	119242481	119242481	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:119242481C>G	uc003ecn.2	+	7	949	c.736C>G	c.(736-738)CTC>GTC	p.L246V	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	246						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		TACTGAGCACCTCCCTGAGAA	0.348			NA											25	87					0	0	0.003954	0	0
STXBP5L	9515	broad.mit.edu	37	3	120959336	120959336	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:120959336C>G	uc003eec.3	+	14	1522	c.1382C>G	c.(1381-1383)CCA>CGA	p.P461R	STXBP5L_uc011bji.1_Missense_Mutation_p.P461R	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	461	WD 8.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		CAAACATATCCAGAAATTATT	0.333			NA											3	57					0	0	0.000248	0	0
COL29A1	256076	broad.mit.edu	37	3	130095427	130095427	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:130095427G>T	uc010htj.1	+	3	909	c.415G>T	c.(415-417)GTG>TTG	p.V139L	COL29A1_uc010hti.1_RNA	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	139	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen					0						CCCAATTTTGGTGGTCCTGGC	0.532			NA											3	22					0.004672	0.00546022	0.004672	1	0
PPM1L	151742	broad.mit.edu	37	3	160786690	160786690	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:160786690C>T	uc003fdr.2	+	4	929	c.828C>T	c.(826-828)AAC>AAT	p.N276N	PPM1L_uc003fds.2_Silent_p.N97N|PPM1L_uc003fdt.2_Silent_p.N149N|PPM1L_uc010hwf.2_RNA	NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	276	Cytoplasmic (Potential).|PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AAAATCTCAACGTGGTCATCC	0.517	Pancreas(86;250 1994 13715 43211)		NA											5	77					0	0	0.000602	0	0
SI	6476	broad.mit.edu	37	3	164777707	164777707	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:164777707C>G	uc003fei.2	-	10	1191	c.1129G>C	c.(1129-1131)GAA>CAA	p.E377Q		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	377	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATGCCAGCTTCCCGGTTTCTC	0.383			NA								HNSCC(35;0.089)			31	501					0	0	0.003271	0	0
CLDN11	5010	broad.mit.edu	37	3	170140986	170140986	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:170140986G>T	uc003fgx.2	+	2	464	c.262G>T	c.(262-264)GCC>TCC	p.A88S	CLDN11_uc011bpt.1_Missense_Mutation_p.A88S|CLDN11_uc003fgy.2_Missense_Mutation_p.A4S	NM_005602	NP_005593	O75508	CLD11_HUMAN	claudin 11	88	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(1)	1	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GATGATTGCTGCCTCGGTCCT	0.617			NA											17	155					5.35267e-07	8.19022e-07	0.007413	1	0
OSTN	344901	broad.mit.edu	37	3	190967879	190967879	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:190967879G>C	uc011bsn.1	+	3	371	c.371G>C	c.(370-372)GGT>GCT	p.G124A		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	124					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		GATCGGATTGGTAGAAACCGG	0.353			NA											7	105					0	0	0.006214	0	0
MFI2	4241	broad.mit.edu	37	3	196749841	196749841	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:196749841T>A	uc003fxk.3	-	5	744	c.631A>T	c.(631-633)AGC>TGC	p.S211C	MFI2_uc003fxl.3_Missense_Mutation_p.S211C|MFI2_uc011bua.1_Silent_p.T183T	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	211	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		AAGGCCCCGCTGTAGTCGTAG	0.627			NA											5	93					0	0	0.000602	0	0
LYAR	55646	broad.mit.edu	37	4	4276496	4276496	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:4276496C>A	uc011bvy.1	-	7	573	c.430G>T	c.(430-432)GAA>TAA	p.E144*	LYAR_uc011bvx.1_Nonsense_Mutation_p.E27*|LYAR_uc003ght.2_Nonsense_Mutation_p.E144*	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	144						nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGACTGGTTCCTTATCATTA	0.418			NA											6	94					8.12818e-05	0.000103228	0.001984	1	0
CCDC96	257236	broad.mit.edu	37	4	7043210	7043210	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:7043210C>A	uc003gjv.2	-	1	1519	c.1456G>T	c.(1456-1458)GAG>TAG	p.E486*	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	486											0						CGCAGCCCCTCTCGGGCTTGC	0.557			NA											27	159					2.12542e-12	3.83784e-12	0.00632	1	0
SORCS2	57537	broad.mit.edu	37	4	7717039	7717039	+	Splice_Site	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:7717039G>T	uc003gkb.3	+	17	2252	c.2252_splice	c.e17+1	p.G751_splice	SORCS2_uc011bwi.1_Splice_Site_p.G579_splice	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor							integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GCAGCCTTGGGTGAGTGTGGG	0.627			NA											3	45					0.004672	0.00546022	0.004672	1	0
GPR125	166647	broad.mit.edu	37	4	22425944	22425944	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:22425944T>C	uc003gqm.1	-	11	1740	c.1475A>G	c.(1474-1476)AAC>AGC	p.N492S	GPR125_uc010ieo.1_Missense_Mutation_p.N366S|GPR125_uc003gqn.1_Missense_Mutation_p.N266S|GPR125_uc003gqo.2_Missense_Mutation_p.N492S	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	492	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				CAACATGATGTTACTTGCAAT	0.458			NA											10	178					0	0	0.006214	0	0
ARAP2	116984	broad.mit.edu	37	4	36161127	36161127	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:36161127C>A	uc003gsq.1	-	14	2781	c.2443G>T	c.(2443-2445)GCT>TCT	p.A815S		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	815					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GCACATAGAGCCTGGTCATTA	0.393			NA											7	57					0.00198382	0.00237684	0.001984	1	0
LRRC66	339977	broad.mit.edu	37	4	52862092	52862092	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:52862092C>A	uc003gzi.2	-	4	1109	c.1096G>T	c.(1096-1098)GGC>TGC	p.G366C		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	366						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TCTTTTTTGCCGGCAGCCTGC	0.592			NA											3	37					0.004672	0.00546022	0.004672	1	0
SPATA18	132671	broad.mit.edu	37	4	52948665	52948665	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:52948665A>T	uc003gzl.2	+	10	1746	c.1468A>T	c.(1468-1470)AGA>TGA	p.R490*	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Nonsense_Mutation_p.R458*|SPATA18_uc003gzk.1_Nonsense_Mutation_p.R490*	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	490					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TGTCACCAGGAGAGGGGCTTT	0.453			NA											8	138					0	0	0.006214	0	0
EPHA5	2044	broad.mit.edu	37	4	66230911	66230911	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:66230911C>T	uc003hcy.2	-	12	2253	c.2060G>A	c.(2059-2061)GGT>GAT	p.G687D	EPHA5_uc003hcx.2_Missense_Mutation_p.G619D|EPHA5_uc003hcz.2_Missense_Mutation_p.G665D|EPHA5_uc011cah.1_Missense_Mutation_p.G688D|EPHA5_uc011cai.1_Missense_Mutation_p.G666D|EPHA5_uc003hda.2_Missense_Mutation_p.G688D	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	687	ATP (By similarity).|Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ACAAACTTCACCAAATTCACC	0.353			NA								TSP Lung(17;0.13)			7	94					0	0	0.001984	0	0
UGT2B10	7365	broad.mit.edu	37	4	69885531	69885531	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:69885531G>A	uc011cao.1	-	4	594	c.458C>T	c.(457-459)CCT>CTT	p.P153L	UGT2B10_uc011can.1_Intron			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	190					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TACGTAGGAAGGAGGGAAAAT	0.408	Melanoma(133;755 1763 25578 26334 46021)		NA											6	136					0	0	0.001984	0	0
ANK2	287	broad.mit.edu	37	4	114264221	114264221	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:114264221C>A	uc003ibe.3	+	34	4271	c.4171C>A	c.(4171-4173)CCA>ACA	p.P1391T	ANK2_uc003ibd.3_Missense_Mutation_p.P1382T|ANK2_uc003ibf.3_Missense_Mutation_p.P1391T|ANK2_uc011cgc.1_Missense_Mutation_p.P567T|ANK2_uc003ibg.3_Missense_Mutation_p.P386T|ANK2_uc003ibh.3_Missense_Mutation_p.P65T|ANK2_uc011cgb.1_Missense_Mutation_p.P1406T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1358					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAACTTGGTACCATTAACTAA	0.333			NA											9	87					7.48243e-07	1.13127e-06	0.006214	1	0
ADAD1	132612	broad.mit.edu	37	4	123333934	123333934	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:123333934C>A	uc003ieo.2	+	10	1451	c.1219C>A	c.(1219-1221)CAG>AAG	p.Q407K	ADAD1_uc003iep.2_Missense_Mutation_p.Q396K|ADAD1_uc003ieq.2_Missense_Mutation_p.Q389K	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	407	A to I editase.			Q -> R (in Ref. 1; BAC04125).	multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TCATTTTATACAGCCAGTTTA	0.403			NA											14	153					5.01169e-05	6.47273e-05	0.00499	1	0
PCDH10	57575	broad.mit.edu	37	4	134072013	134072013	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:134072013G>C	uc003iha.2	+	1	1544	c.718G>C	c.(718-720)GTG>CTG	p.V240L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.V240L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	240	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CACCATCCGAGTGCTGGACTC	0.463			NA											8	73					0	0	0.004482	0	0
GALNTL6	442117	broad.mit.edu	37	4	172735814	172735814	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:172735814G>A	uc003isv.2	+	2	819	c.83G>A	c.(82-84)TGG>TAG	p.W28*		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	28	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GTTGGTCTCTGGTCTCTGTAC	0.483			NA											4	43					0	0	0.000248	0	0
ODZ3	55714	broad.mit.edu	37	4	183652148	183652149	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr4:183652148_183652149CC>AA	uc003ivd.1	+	15	2860_2861	c.2823_2824CC>AA	c.(2821-2826)ACCCTA>ACAATA	p.L942I	ODZ3_uc003ive.1_Missense_Mutation_p.L348I	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	942	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGATGGATACCCTAGTCATGAA	0.426			NA											7	62					0	0	0.004672	0	0
KIAA0947	23379	broad.mit.edu	37	5	5462198	5462198	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:5462198G>A	uc003jdm.3	+	13	2973	c.2751G>A	c.(2749-2751)GAG>GAA	p.E917E		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	917										ovary(1)|central_nervous_system(1)	2						ACATCACGGAGGTGGCTGCTG	0.398			NA											5	104					0	0	0.000602	0	0
SEMA5A	9037	broad.mit.edu	37	5	9063002	9063002	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:9063002G>T	uc003jek.2	-	18	3227	c.2515C>A	c.(2515-2517)CCA>ACA	p.P839T		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	839	TSP type-1 5.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CACTTACCTGGGCAGGGCAAA	0.512			NA											22	65					1.85244e-09	3.1368e-09	0.00333	1	0
PRDM9	56979	broad.mit.edu	37	5	23522490	23522490	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:23522490G>A	uc003jgo.2	+	7	768	c.586G>A	c.(586-588)GAG>AAG	p.E196K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	196					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAGGTCAGCGAGCCGCAGGA	0.458			NA								HNSCC(3;0.000094)			32	221					0	0	0.004878	0	0
RXFP3	51289	broad.mit.edu	37	5	33936931	33936931	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:33936931C>T	uc003jic.1	+	1	443	c.86C>T	c.(85-87)CCG>CTG	p.P29L		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	29	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						AGTCTGGTCCCGGACCTTCTG	0.632			NA											10	82					0	0	0.000978	0	0
EGFLAM	133584	broad.mit.edu	37	5	38425138	38425138	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:38425138C>A	uc003jlc.1	+	13	2078	c.1754C>A	c.(1753-1755)GCC>GAC	p.A585D	EGFLAM_uc003jlb.1_Missense_Mutation_p.A585D|EGFLAM_uc003jle.1_Missense_Mutation_p.A351D|EGFLAM_uc003jlf.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	585	EGF-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GCAATCAAAGCCGACTCCTAC	0.473	Colon(62;485 1295 3347 17454)		NA											59	121					9.53978e-28	1.86393e-27	0.00361	1	0
ZNF131	7690	broad.mit.edu	37	5	43161516	43161516	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:43161516G>T	uc011cpw.1	+	5	573	c.537G>T	c.(535-537)GTG>GTT	p.V179V	ZNF131_uc010ivl.1_Silent_p.V179V|ZNF131_uc003jnj.3_5'UTR|ZNF131_uc003jnk.2_Silent_p.V179V|ZNF131_uc003jnn.3_5'UTR|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	179						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCATTGAAGTGGAAGATGAAG	0.443			NA											5	99					3.59834e-05	4.72747e-05	0.001168	1	0
HMGCR	3156	broad.mit.edu	37	5	74655898	74655898	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:74655898G>T	uc003kdp.2	+	19	2702	c.2546G>T	c.(2545-2547)GGG>GTG	p.G849V	HMGCR_uc011cst.1_Missense_Mutation_p.G869V|HMGCR_uc003kdq.2_Missense_Mutation_p.G796V|HMGCR_uc010izo.2_Missense_Mutation_p.G119V|HMGCR_uc010izp.2_Missense_Mutation_p.G72V	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	849	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GTAATGGCTGGGGAATTGTCA	0.478			NA											11	112					3.86212e-05	5.02207e-05	0.008291	1	0
AGGF1	55109	broad.mit.edu	37	5	76342310	76342310	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:76342310A>G	uc003ket.2	+	6	1369	c.1009A>G	c.(1009-1011)ACT>GCT	p.T337A		NM_018046	NP_060516	Q8N302	AGGF1_HUMAN	angiogenic factor VG5Q	337					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CACTGTTCCAACTAGTGGAAA	0.363			NA											43	146					0	0	0.002222	0	0
RASGRF2	5924	broad.mit.edu	37	5	80409612	80409612	+	Silent	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:80409612T>C	uc003kha.1	+	15	2343	c.2343T>C	c.(2341-2343)ACT>ACC	p.T781T	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	781					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CACCACACACTGGTCAGATAC	0.552			NA											6	62					0	0	0.001984	0	0
LOX	4015	broad.mit.edu	37	5	121409740	121409740	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:121409740G>T	uc003ksu.2	-	4	1378	c.1003C>A	c.(1003-1005)CAC>AAC	p.H335N	LOX_uc010jcp.2_Missense_Mutation_p.H38N|LOX_uc010jcq.2_Missense_Mutation_p.H38N|LOX_uc011cwk.1_Missense_Mutation_p.H105N|LOX_uc010jcr.2_Missense_Mutation_p.H38N	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	335	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		AATCGCCTGTGGTAGCCATAG	0.498			NA											24	254					3.28513e-13	6.01747e-13	0.003954	1	0
PCDHA7	56141	broad.mit.edu	37	5	140215057	140215057	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:140215057C>A	uc003lhq.2	+	1	1089	c.1089C>A	c.(1087-1089)GCC>GCA	p.A363A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.A363A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	363	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGGACGCCCAACCAGGTA	0.507	NSCLC(160;258 2013 5070 22440 28951)		NA											8	170					0.00448238	0.00528727	0.004482	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604624	140604625	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:140604624_140604625TC>AA	uc003ljb.2	+	1	1547_1548	c.1547_1548TC>AA	c.(1546-1548)CTC>CAA	p.L516Q	PCDHB14_uc011dal.1_Missense_Mutation_p.L363Q	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	516	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTTTGCCCTCAGGTCGCTGG	0.678	Ovarian(141;50 1831 27899 33809 37648)		NA											10	129					0	0	0.004672	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711999	140711999	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:140711999A>T	uc003lji.1	+	1	1748	c.1748A>T	c.(1747-1749)GAG>GTG	p.E583V	PCDHGA1_uc011dan.1_Missense_Mutation_p.E583V	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	583	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCCGCAGAGCCCGGCTAC	0.672			NA											11	120					0	0	0.000978	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774290	140774290	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:140774290C>A	uc003lkd.1	+	1	2808	c.1910C>A	c.(1909-1911)GCG>GAG	p.A637E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.A637E	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	637	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGAGATGCGCTCAAGCAG	0.682			NA											6	38					0.00116845	0.00142685	0.001168	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774680	140774680	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:140774680A>C	uc003lkd.1	+	1	3198	c.2300A>C	c.(2299-2301)CAC>CCC	p.H767P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.H767P	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	767	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAAGAGTCACCTGATCTTT	0.507			NA											16	90					0	0	0.006122	0	0
RBM27	54439	broad.mit.edu	37	5	145665588	145665588	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:145665588A>G	uc003lnz.3	+	21	3344	c.3178A>G	c.(3178-3180)AGA>GGA	p.R1060G		NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	1060					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCATGGCGAAGATGAAATCT	0.308			NA											5	68					0	0	0.000602	0	0
OR2J2	26707	broad.mit.edu	37	6	29141761	29141761	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:29141761G>T	uc011dlm.1	+	1	451	c.349G>T	c.(349-351)GTG>TTG	p.V117L		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTCCTACTGGTGGTGATGTC	0.488			NA											71	366					4.29146e-36	8.51586e-36	0.00361	1	0
HLA-DQA2	3118	broad.mit.edu	37	6	32712989	32712989	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:32712989G>A	uc003obx.2	+	2	194	c.136G>A	c.(136-138)GGC>AGC	p.G46S		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	46	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGGTCCCTCTGGCCAGTACAC	0.498			NA											27	140					0	0	0.00632	0	0
DNAH8	1769	broad.mit.edu	37	6	38818065	38818065	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:38818065A>T	uc003ooe.1	+	36	5187	c.4587A>T	c.(4585-4587)ATA>ATT	p.I1529I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGTCTTGGATAAAAATAATGC	0.363			NA											15	73					0	0	0.004007	0	0
FRS3	10817	broad.mit.edu	37	6	41740639	41740639	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:41740639C>A	uc003orc.1	-	5	556	c.312G>T	c.(310-312)CTG>CTT	p.L104L		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	104	IRS-type PTB.				fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGCACTGCATCAGATCCTGAA	0.527			NA											5	76					1.23904e-05	1.71041e-05	0.000602	1	0
PKHD1	5314	broad.mit.edu	37	6	51920529	51920529	+	Splice_Site	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:51920529T>C	uc003pah.1	-	19	1970	c.1694_splice	c.e19-1	p.G565_splice	PKHD1_uc003pai.2_Splice_Site_p.G565_splice	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTTCTGGGCCTGGATGCAGTT	0.483			NA											4	25					0	0	0.000248	0	0
BAI3	577	broad.mit.edu	37	6	69349092	69349092	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:69349092G>T	uc003pev.3	+	3	973	c.525G>T	c.(523-525)TTG>TTT	p.L175F	BAI3_uc010kak.2_Missense_Mutation_p.L175F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	175	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GTACTTGGTTGGAGAGCTGCT	0.423			NA											14	82					0.00316338	0.0037664	0.003163	1	0
GPRC6A	222545	broad.mit.edu	37	6	117127972	117127972	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:117127972C>G	uc003pxj.1	-	3	918	c.896G>C	c.(895-897)TGG>TCG	p.W299S	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.W299S	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	299	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACTAGCAATCCACATCTTATT	0.353			NA											5	73					0	0	0.000602	0	0
TAAR8	83551	broad.mit.edu	37	6	132874369	132874369	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:132874369G>T	uc011ecj.1	+	1	538	c.538G>T	c.(538-540)GTA>TTA	p.V180L		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	180	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		GGAGGAATTAGTAAGTGCTCT	0.453			NA											51	227					4.78724e-31	9.45046e-31	0.00361	1	0
BCLAF1	9774	broad.mit.edu	37	6	136599712	136599712	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:136599712T>C	uc003qgx.1	-	4	560	c.307A>G	c.(307-309)AGG>GGG	p.R103G	BCLAF1_uc003qgw.1_Missense_Mutation_p.R103G|BCLAF1_uc003qgy.1_Missense_Mutation_p.R101G|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R101G	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	103					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTAGGACTCCTAGAGTGCCTT	0.473	Colon(142;1534 1789 5427 7063 28491)		NA											14	259					0	0	0.003163	0	0
MAP3K5	4217	broad.mit.edu	37	6	137018358	137018358	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:137018358T>A	uc003qhc.2	-	5	1335	c.974A>T	c.(973-975)CAG>CTG	p.Q325L	MAP3K5_uc011edk.1_Missense_Mutation_p.Q170L|MAP3K5_uc010kgw.1_Missense_Mutation_p.Q325L	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	325					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TCTTCTCACCTGGATATCTCT	0.393			NA											7	50					0	0	0.001984	0	0
TULP4	56995	broad.mit.edu	37	6	158923658	158923658	+	Missense_Mutation	SNP	G	G	A	rs143675661		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr6:158923658G>A	uc003qrf.2	+	13	4320	c.2963G>A	c.(2962-2964)CGG>CAG	p.R988Q	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	988					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GCTACCCTGCGGAGGAACAAC	0.711			NA											6	26					0	0	0.001168	0	0
HOXA1	3198	broad.mit.edu	37	7	27134270	27134270	+	Missense_Mutation	SNP	A	A	T	rs41311763		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:27134270A>T	uc003sye.2	-	2	891	c.797T>A	c.(796-798)CTG>CAG	p.L266Q	HOXA1_uc003syd.2_3'UTR|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	266	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						GTTGAGCTGCAGGGATGCAGC	0.567			NA											6	100					0	0	0.001984	0	0
POU6F2	11281	broad.mit.edu	37	7	39500186	39500186	+	Silent	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:39500186G>C	uc003thb.1	+	9	1485	c.1443G>C	c.(1441-1443)CTG>CTC	p.L481L		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	481	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GGGTTAATCTGGAGGAGATCC	0.512			NA											6	24					0	0	0.001168	0	0
POM121L12	285877	broad.mit.edu	37	7	53104090	53104090	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:53104090C>A	uc003tpz.2	+	1	742	c.726C>A	c.(724-726)CCC>CCA	p.P242P		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	242											0						GCCTCGGCCCCTGGAGCCTCA	0.647			NA											6	43					2.0095e-06	2.9334e-06	0.001984	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86526823	86526823	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:86526823T>G	uc011kha.1	-	19	2869	c.2684A>C	c.(2683-2685)CAG>CCG	p.Q895P	KIAA1324L_uc003uif.1_Missense_Mutation_p.Q655P|KIAA1324L_uc011kgz.1_Missense_Mutation_p.Q781P|KIAA1324L_uc003uie.2_Missense_Mutation_p.Q728P	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	895	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					ATCCCTTACCTGAAATCCTCT	0.468			NA											5	106					0	0	0.000602	0	0
OR2AE1	81392	broad.mit.edu	37	7	99474394	99474394	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:99474394C>A	uc003usc.1	-	1	263	c.263G>T	c.(262-264)GGC>GTC	p.G88V		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGATTTCTTGCCAGATAGGTA	0.463			NA											16	69					6.94344e-10	1.1863e-09	0.006122	1	0
ZAN	7455	broad.mit.edu	37	7	100388611	100388611	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:100388611G>T	uc003uwj.2	+	41	7570	c.7405G>T	c.(7405-7407)GGA>TGA	p.G2469*	ZAN_uc003uwk.2_Nonsense_Mutation_p.G2469*|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2469	VWFD 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGGCCTGTGCGGAAACTACGA	0.547			NA											4	10					2.56e-06	3.6806e-06	0.000248	1	0
SLC12A9	56996	broad.mit.edu	37	7	100457848	100457848	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:100457848G>A	uc003uwp.2	+	9	1354	c.1212G>A	c.(1210-1212)CTG>CTA	p.L404L	SLC12A9_uc003uwq.2_Silent_p.L315L|SLC12A9_uc011kki.1_5'UTR|SLC12A9_uc003uwr.2_Silent_p.L140L|SLC12A9_uc003uws.2_5'UTR|SLC12A9_uc003uwt.2_Silent_p.L140L|SLC12A9_uc003uwv.2_5'UTR	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	404	Helical; (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTTGGGGCCTGGTGCAGGTGA	0.567			NA											8	37					0	0	0.00308	0	0
MUC17	140453	broad.mit.edu	37	7	100680748	100680748	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:100680748C>T	uc003uxp.1	+	3	6104	c.6051C>T	c.(6049-6051)ACC>ACT	p.T2017T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2017	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCTGCCACCACTTCTACTG	0.522			NA											36	298					0	0	0.00361	0	0
CBLL1	79872	broad.mit.edu	37	7	107399240	107399240	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:107399240C>T	uc003veq.2	+	6	1423	c.1093C>T	c.(1093-1095)CCT>TCT	p.P365S	CBLL1_uc011kme.1_Missense_Mutation_p.P244S|CBLL1_uc011kmf.1_Missense_Mutation_p.P364S	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	365	Pro-rich.				cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						TGCAGGTACTCCTCACTTGGT	0.527			NA											14	257					0	0	0.00499	0	0
LRRN3	54674	broad.mit.edu	37	7	110763529	110763529	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:110763529G>C	uc003vft.3	+	4	1747	c.701G>C	c.(700-702)GGA>GCA	p.G234A	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.G234A|LRRN3_uc003vfs.3_Missense_Mutation_p.G234A	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	234	Extracellular (Potential).|LRR 7.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GCCTTGGTTGGACTGGAAAAC	0.363			NA											21	70					0	0	0.008871	0	0
ZNF277	11179	broad.mit.edu	37	7	111970197	111970197	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:111970197A>G	uc003vge.2	+	7	856	c.727A>G	c.(727-729)ATG>GTG	p.M243V	ZNF277_uc003vgd.2_Missense_Mutation_p.M243V|ZNF277_uc003vgf.2_Missense_Mutation_p.M165V|ZNF277_uc003vgg.2_Missense_Mutation_p.M68V	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	243	C2H2-type 1.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4						TAAAGATCACATGAGGAAAAA	0.323			NA											7	39					0	0	0.00308	0	0
SPAM1	6677	broad.mit.edu	37	7	123594320	123594320	+	Silent	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:123594320C>T	uc003vld.2	+	4	1098	c.696C>T	c.(694-696)CCC>CCT	p.P232P	SPAM1_uc003vle.2_Silent_p.P232P|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.P232P|SPAM1_uc010lku.2_Silent_p.P232P	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	232					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	ATAAGAAACCCGGTTACAATG	0.368			NA											17	106					0	0	0.004007	0	0
AKR1D1	6718	broad.mit.edu	37	7	137790082	137790082	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:137790082G>C	uc003vtz.2	+	5	555	c.486G>C	c.(484-486)TTG>TTC	p.L162F	AKR1D1_uc011kqb.1_Missense_Mutation_p.L162F|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_RNA|AKR1D1_uc011kqe.1_Missense_Mutation_p.L162F|AKR1D1_uc011kqf.1_Intron|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	162					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						ACGCTGGCTTGGTGAAATCCC	0.488			NA											36	180					0	0	0.003271	0	0
MGAM	8972	broad.mit.edu	37	7	141752752	141752752	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:141752752A>T	uc003vwy.2	+	26	3181	c.3127A>T	c.(3127-3129)ACT>TCT	p.T1043S		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1043	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGGATGTCACTTACCATAA	0.458			NA											9	73					0	0	0.004482	0	0
EPHB6	2051	broad.mit.edu	37	7	142564758	142564758	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:142564758G>T	uc011kst.1	+	11	2469	c.1682G>T	c.(1681-1683)CGG>CTG	p.R561L	EPHB6_uc011ksu.1_Missense_Mutation_p.R561L|EPHB6_uc003wbs.2_Missense_Mutation_p.R269L|EPHB6_uc003wbt.2_Missense_Mutation_p.R35L|EPHB6_uc003wbu.2_Missense_Mutation_p.R269L|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	561	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TTCCAGGTGCGGGCCCGGACT	0.622			NA											8	54					0.00448238	0.00528727	0.004482	1	0
C7orf34	135927	broad.mit.edu	37	7	142637620	142637620	+	Silent	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:142637620G>C	uc003wca.2	+	2	431	c.390G>C	c.(388-390)GGG>GGC	p.G130G		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	105						extracellular region					0	Melanoma(164;0.059)					TCTCAGGAGGGCCATTGAGGC	0.537			NA											10	138					0	0	0.006214	0	0
OR2F2	135948	broad.mit.edu	37	7	143632883	143632883	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:143632883G>T	uc011ktv.1	+	1	558	c.558G>T	c.(556-558)AGG>AGT	p.R186S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CTGTGGTCAGGCTGGCTTGTG	0.488			NA											5	103					0.00116845	0.00142685	0.001168	1	0
OR2F2	135948	broad.mit.edu	37	7	143633190	143633190	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:143633190A>C	uc011ktv.1	+	1	865	c.865A>C	c.(865-867)ATT>CTT	p.I289L		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GAACCCTGTGATTTATAGTCT	0.443			NA											9	91					0	0	0.004482	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829427	146829427	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:146829427C>A	uc003weu.1	+	8	1690	c.1174C>A	c.(1174-1176)CAG>AAG	p.Q392K		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	392	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACGGCTTAACCAGGACCTGTT	0.468			NA								HNSCC(39;0.1)			21	130					2.4624e-09	4.13292e-09	0.008871	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147259256	147259256	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:147259256T>A	uc003weu.1	+	12	2320	c.1804T>A	c.(1804-1806)TAC>AAC	p.Y602N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	602	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGTGAAGCCTACAAACACCT	0.453			NA								HNSCC(39;0.1)			8	60					0	0	0.00308	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147914435	147914435	+	Silent	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:147914435A>G	uc003weu.1	+	19	3582	c.3066A>G	c.(3064-3066)CCA>CCG	p.P1022P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1022	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTCAGGCACCAGCAACAAATG	0.493			NA								HNSCC(39;0.1)			18	93					0	0	0.006122	0	0
KRBA1	84626	broad.mit.edu	37	7	149425649	149425649	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:149425649G>A	uc003wfz.2	+	12	1909	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Missense_Mutation_p.E172K	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	504										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCAGGGTCTGGAGAATTGTCT	0.582			NA											9	152					0	0	0.001368	0	0
MLL3	58508	broad.mit.edu	37	7	152008931	152008931	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr7:152008931C>G	uc003wla.2	-	5	910	c.691G>C	c.(691-693)GTT>CTT	p.V231L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	231					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGAAGCCCAACCAGACTGAGT	0.413	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								16	89					0	0	0.00499	0	0
RP1L1	94137	broad.mit.edu	37	8	10467307	10467307	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:10467307C>A	uc003wtc.2	-	4	4530	c.4301G>T	c.(4300-4302)AGA>ATA	p.R1434I		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1434					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GGCAGAGGCTCTTCCTGCTTC	0.627			NA											10	373					2.17888e-05	2.96483e-05	0.006214	1	0
PSD3	23362	broad.mit.edu	37	8	18393390	18393390	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:18393390C>A	uc003wza.2	-	16	3110	c.3007G>T	c.(3007-3009)GCA>TCA	p.A1003S	PSD3_uc003wyx.3_Missense_Mutation_p.A332S|PSD3_uc003wyy.2_Missense_Mutation_p.A469S|PSD3_uc003wyz.2_Missense_Mutation_p.A304S	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	1004					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTCAGTCCTGCAGCCTCGCTT	0.498			NA											7	102					1.06961e-07	1.68398e-07	0.00308	1	0
REEP4	80346	broad.mit.edu	37	8	21996976	21996976	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:21996976G>T	uc003xau.1	-	5	823	c.370C>A	c.(370-372)CGG>AGG	p.R124R	REEP4_uc010ltt.1_Silent_p.R124R|REEP4_uc011kyz.1_Silent_p.R124R	NM_025232	NP_079508	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	124						integral to membrane				skin(1)	1				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		TTGAGGCCCCGCTTCCCGAAG	0.662			NA											8	36					0.00448238	0.00528727	0.004482	1	0
NRG1	3084	broad.mit.edu	37	8	32463156	32463156	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:32463156G>A	uc003xiv.2	+	3	872	c.355G>A	c.(355-357)GGA>AGA	p.G119R	NRG1_uc003xip.2_Missense_Mutation_p.G334R|NRG1_uc003xir.2_Missense_Mutation_p.G119R|NRG1_uc010lvl.2_Missense_Mutation_p.G119R|NRG1_uc010lvm.2_Missense_Mutation_p.G119R|NRG1_uc010lvn.2_Missense_Mutation_p.G119R|NRG1_uc003xis.2_Missense_Mutation_p.G119R|NRG1_uc011lbf.1_Missense_Mutation_p.G119R|NRG1_uc010lvo.2_Missense_Mutation_p.G119R|NRG1_uc003xiu.2_Missense_Mutation_p.G119R|NRG1_uc003xiw.2_Missense_Mutation_p.G119R|NRG1_uc003xit.2_Missense_Mutation_p.G119R|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Missense_Mutation_p.G85R|NRG1_uc010lvq.2_Missense_Mutation_p.G85R|NRG1_uc003xix.2_Missense_Mutation_p.G9R	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	119	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CAGCAAATTAGGAAATGACAG	0.408			NA											4	91					0	0	0.000248	0	0
RNF5P1	286140	broad.mit.edu	37	8	38458672	38458672	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:38458672C>T	uc003xly.2	-	1	104	c.47G>A	c.(46-48)CGC>CAC	p.R16H		NR_003129				SubName: Full=Putative uncharacterized protein RNF5;												0						GCCCCGCTCGCGATTTGGCCC	0.617			NA											4	30					0	0	0.000248	0	0
ANK1	286	broad.mit.edu	37	8	41550708	41550708	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:41550708G>T	uc003xok.2	-	30	3628	c.3544C>A	c.(3544-3546)CAA>AAA	p.Q1182K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.Q498K|ANK1_uc003xoi.2_Missense_Mutation_p.Q1182K|ANK1_uc003xoj.2_Missense_Mutation_p.Q1182K|ANK1_uc003xol.2_Missense_Mutation_p.Q1182K|ANK1_uc003xom.2_Missense_Mutation_p.Q1223K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1182					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CACTGGGCTTGGTCTGTTCCT	0.527			NA											7	69					5.18039e-06	7.33728e-06	0.00308	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766156	77766156	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:77766156G>T	uc003yav.2	+	10	7251	c.6864G>T	c.(6862-6864)AAG>AAT	p.K2288N	ZFHX4_uc003yau.1_Missense_Mutation_p.K2333N|ZFHX4_uc003yaw.1_Missense_Mutation_p.K2288N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2288	C2H2-type 15; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCAGAAAAAGCAGTGTTACA	0.423			NA								HNSCC(33;0.089)			18	115					6.33239e-15	1.18849e-14	0.001523	1	0
PGCP	10404	broad.mit.edu	37	8	97892129	97892129	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:97892129G>T	uc003yhw.2	+	4	911	c.745G>T	c.(745-747)GGG>TGG	p.G249W	PGCP_uc010mbe.2_Missense_Mutation_p.G249W	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	249					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGCTTCTCATGGGATCAAAAT	0.453			NA											33	243					7.11191e-15	1.32825e-14	0.002836	1	0
VPS13B	157680	broad.mit.edu	37	8	100520069	100520069	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:100520069G>T	uc003yiv.2	+	28	4340	c.4229G>T	c.(4228-4230)AGA>ATA	p.R1410I	VPS13B_uc003yiw.2_Intron|VPS13B_uc003yiu.1_3'UTR|VPS13B_uc003yix.1_Missense_Mutation_p.R880I	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1410					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGCTGAACAGACGCACCTTG	0.463	Colon(161;2205 2542 7338 31318)		NA											7	81					2.0095e-06	2.9334e-06	0.001984	1	0
ANGPT1	284	broad.mit.edu	37	8	108306234	108306234	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:108306234C>A	uc003ymn.2	-	6	1436	c.968G>T	c.(967-969)GGT>GTT	p.G323V	ANGPT1_uc011lhv.1_Missense_Mutation_p.G123V|ANGPT1_uc003ymo.2_Missense_Mutation_p.G322V|ANGPT1_uc003ymp.3_Missense_Mutation_p.G122V	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	323	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TACAGTCCAACCTCCCCCATT	0.343			NA											5	97					0.00198382	0.00237684	0.001984	1	0
CSMD3	114788	broad.mit.edu	37	8	114448979	114448979	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:114448979C>A	uc003ynu.2	-	1	264	c.105G>T	c.(103-105)ATG>ATT	p.M35I	CSMD3_uc011lhx.1_Missense_Mutation_p.M35I|CSMD3_uc010mcx.1_Missense_Mutation_p.M35I|CSMD3_uc003ynx.3_Missense_Mutation_p.M35I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	35	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATTTTCTTCATCAGGATGA	0.502			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	168					3.51602e-12	6.25982e-12	0.008871	1	0
TG	7038	broad.mit.edu	37	8	133882039	133882039	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:133882039T>C	uc003ytw.2	+	3	283	c.242T>C	c.(241-243)CTG>CCG	p.L81P		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	81	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGTGAAGTGCTGGGCAGCAGG	0.627			NA											3	52					0	0	0.004672	0	0
FAM135B	51059	broad.mit.edu	37	8	139151231	139151231	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:139151231G>C	uc003yuy.2	-	18	4070	c.3899C>G	c.(3898-3900)ACA>AGA	p.T1300R	FAM135B_uc003yux.2_Missense_Mutation_p.T1201R|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1300										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCACTGACCTGTTTTTTGGCT	0.443			NA								HNSCC(54;0.14)			15	61					0	0	0.003163	0	0
TSTA3	7264	broad.mit.edu	37	8	144698279	144698279	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:144698279G>A	uc003yza.2	-	3	294	c.258C>T	c.(256-258)TTC>TTT	p.F86F	TSTA3_uc003yzb.2_Silent_p.F86F|TSTA3_uc011lko.1_Silent_p.F86F	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	86					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	CACTTACCCAGAAGTCCAAAT	0.567			NA											4	45					0	0	0.000248	0	0
TESK1	7016	broad.mit.edu	37	9	35606261	35606261	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:35606261A>T	uc003zxa.2	+	3	705	c.369A>T	c.(367-369)GGA>GGT	p.G123G	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_5'UTR	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	123	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCACCAGGGACAGCTGCACG	0.562			NA											8	71					0	0	0.006214	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625022	43625022	+	Missense_Mutation	SNP	G	G	T	rs150951585	by1000genomes	TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:43625022G>T	uc011lrb.1	-	4	3694	c.3665C>A	c.(3664-3666)GCG>GAG	p.A1222E		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1222						integral to membrane					0						GGCATGGTGCGCATGGCAAAG	0.493			NA											27	551					1.13719e-10	1.9784e-10	0.008361	1	0
TRPM6	140803	broad.mit.edu	37	9	77377968	77377968	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:77377968G>A	uc004ajl.1	-	26	3857	c.3619C>T	c.(3619-3621)CAG>TAG	p.Q1207*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Q1202*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Nonsense_Mutation_p.Q163*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1207	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGTCCCACCTGGCTGTCCAAA	0.483			NA											16	96					0	0	0.004007	0	0
SEMA4D	10507	broad.mit.edu	37	9	92002517	92002517	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:92002517C>T	uc004aqo.1	-	14	1686	c.1114G>A	c.(1114-1116)GAC>AAC	p.D372N	SEMA4D_uc011ltm.1_Missense_Mutation_p.D372N|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Missense_Mutation_p.D370N	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	372	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GCCTCGCTGTCGATGCACTGC	0.572			NA											5	55					0	0	0.001168	0	0
PRPF4	9128	broad.mit.edu	37	9	116041389	116041389	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:116041389G>T	uc004bgx.2	+	3	423	c.373G>T	c.(373-375)GGT>TGT	p.G125C	PRPF4_uc004bgy.2_Missense_Mutation_p.G124C	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	125						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding	p.G125S(1)		ovary(2)|pancreas(1)	3						TTTTGGAGAGGGTCCTGCTGA	0.418			NA											9	59					3.09899e-07	4.78022e-07	0.004482	1	0
NAIF1	203245	broad.mit.edu	37	9	130829231	130829231	+	Silent	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:130829231G>A	uc004bta.2	-	1	369	c.150C>T	c.(148-150)GGC>GGT	p.G50G	NAIF1_uc004bsz.2_RNA|SLC25A25_uc004btb.2_5'Flank	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	50	Required for nuclear localization and apoptosis-inducing activity.				apoptosis|induction of apoptosis	nucleus					0						TTCTCAGGATGCCGTGCCAGG	0.622			NA											16	80					0	0	0.003163	0	0
MXRA5	25878	broad.mit.edu	37	X	3235811	3235811	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:3235811C>A	uc004crg.3	-	6	6068	c.5911G>T	c.(5911-5913)GAG>TAG	p.E1971*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1971	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCAGACACTCCATTGCAATG	0.587			NA											4	73					0.000602214	0.000744947	0.000602	1	0
STS	412	broad.mit.edu	37	X	7175602	7175602	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:7175602G>T	uc004cry.3	+	4	615	c.370G>T	c.(370-372)GAT>TAT	p.D124Y		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	124	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity	p.D124N(1)		central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GCTTCTGAAGGATCAAGGTTA	0.483			NA							Ichthyosis				7	184					0.000157383	0.000198553	0.00308	1	0
VCX3B	425054	broad.mit.edu	37	X	8433568	8433568	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:8433568C>A	uc010ndo.2	+	2	384	c.77C>A	c.(76-78)CCG>CAG	p.P26Q	VCX3B_uc011mht.1_Missense_Mutation_p.P26Q|VCX3B_uc004csd.1_Missense_Mutation_p.P26Q	NM_001001888	NP_001001888	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	26						nucleolus					0						TCCTCTCAGCCGAGCCCCAGT	0.607			NA											13	94					1.02788e-11	1.80472e-11	0.00499	1	0
WWC3	55841	broad.mit.edu	37	X	10092351	10092351	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:10092351G>C	uc004csx.3	+	13	1996	c.1798G>C	c.(1798-1800)GGA>CGA	p.G600R	WWC3_uc010nds.2_Missense_Mutation_p.G264R|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	600										ovary(4)	4						GGCCAGTAACGGAGATCCCCA	0.607			NA											7	65					0	0	0.001984	0	0
PRPS2	5634	broad.mit.edu	37	X	12828215	12828215	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:12828215C>A	uc004cvb.2	+	4	604	c.480C>A	c.(478-480)GCC>GCA	p.A160A	PRPS2_uc004cva.2_Silent_p.A163A|PRPS2_uc010nec.2_Silent_p.A96A	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	160					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						AAAACATTGCCGAGTGGAAGA	0.468			NA											9	119					1.76689e-08	2.88921e-08	0.006214	1	0
CNKSR2	22866	broad.mit.edu	37	X	21627613	21627613	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:21627613G>C	uc004czx.1	+	20	2606	c.2570G>C	c.(2569-2571)TGT>TCT	p.C857S	CNKSR2_uc004czw.2_Missense_Mutation_p.C857S|CNKSR2_uc011mjn.1_Missense_Mutation_p.C808S|CNKSR2_uc011mjo.1_Missense_Mutation_p.C827S|CNKSR2_uc004czy.2_Missense_Mutation_p.C449S	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	857					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AACCATTGCTGTCTGAATGCT	0.413			NA											4	125					0	0	0.000248	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27765783	27765783	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:27765783G>C	uc011mjy.1	+	1	858	c.771G>C	c.(769-771)TGG>TGC	p.W257C		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						TGTGGGACTGGGTGCGGCAGA	0.517			NA											7	28					0	0	0.001984	0	0
FTHL17	53940	broad.mit.edu	37	X	31089982	31089982	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:31089982T>A	uc004dcl.1	-	1	192	c.89A>T	c.(88-90)TAC>TTC	p.Y30F		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	30	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						GTAGGAGGTGTAGAGCTCCAG	0.622			NA											4	81					0	0	0.000248	0	0
FAM47A	158724	broad.mit.edu	37	X	34148334	34148334	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:34148334C>A	uc004ddg.2	-	1	2095	c.2062G>T	c.(2062-2064)GCA>TCA	p.A688S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	688										ovary(4)|central_nervous_system(1)	5						ACACGCTGTGCGGTATAAGAA	0.438			NA											6	136					2.0095e-06	2.9334e-06	0.001984	1	0
CXorf59	286464	broad.mit.edu	37	X	36162711	36162711	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:36162711G>C	uc004ddk.1	+	11	1480	c.1294G>C	c.(1294-1296)GCA>CCA	p.A432P		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	432						integral to membrane				central_nervous_system(1)	1						ggagatggatgcaggagtcag	0			NA											4	173					0	0	0.000248	0	0
SYTL5	94122	broad.mit.edu	37	X	37969676	37969676	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:37969676C>A	uc004ddu.2	+	14	2071	c.1537C>A	c.(1537-1539)CCT>ACT	p.P513T	SYTL5_uc004ddv.2_Missense_Mutation_p.P513T|SYTL5_uc004ddx.2_Missense_Mutation_p.P535T	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	513					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						AGTAGAGATTCCTTTTGACTC	0.443			NA											12	147					0.00010058	0.000127312	0.001368	1	0
SSX5	6758	broad.mit.edu	37	X	48053613	48053613	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:48053613C>A	uc004dja.1	-	4	285	c.232G>T	c.(232-234)GAC>TAC	p.D78Y	SSX5_uc004diz.1_Missense_Mutation_p.D119Y	NM_175723	NP_783729	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5 isoform b	78	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						CCCTGGAAGTCTGCGACCCGT	0.448			NA											14	225					9.31168e-06	1.31398e-05	0.001855	1	0
Unknown	0	broad.mit.edu	37	X	48159066	48159066	+	Splice_Site	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:48159066C>G	uc010nib.1	-	6	553	c.466_splice	c.e6+1	p.G156_splice		NM_174962	NP_777622			synovial sarcoma, X breakpoint 9												NA						TTTCCTCTTCCCAGATGCCTT	0.527			NA											35	252					0	0	0.003755	0	0
WNK3	65267	broad.mit.edu	37	X	54259271	54259271	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:54259271G>T	uc004dtd.1	-	21	5109	c.4670C>A	c.(4669-4671)ACA>AAA	p.T1557K	WNK3_uc004dtc.1_Missense_Mutation_p.T1604K	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1557					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GTCCACATGTGTCAAGGACTG	0.363			NA											14	146					2.31682e-05	3.14131e-05	0.003163	1	0
RGAG4	340526	broad.mit.edu	37	X	71349932	71349932	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:71349932C>A	uc010nlh.1	-	1	1820	c.1459G>T	c.(1459-1461)GGT>TGT	p.G487C	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	487										ovary(2)|skin(1)	3	Renal(35;0.156)					GCGTGGTAACCACTTGTGGGG	0.557			NA											13	47					0.00136819	0.00166013	0.001368	1	0
CYLC1	1538	broad.mit.edu	37	X	83128659	83128659	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:83128659A>G	uc004eei.1	+	4	964	c.943A>G	c.(943-945)AAA>GAA	p.K315E	CYLC1_uc004eeh.1_Missense_Mutation_p.K314E	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	315	2.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						GAAAGTTAAGAAAAATGTCAA	0.308			NA											13	57					0	0	0.001855	0	0
HDX	139324	broad.mit.edu	37	X	83730391	83730391	+	Silent	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:83730391A>T	uc004eek.1	-	2	124	c.15T>A	c.(13-15)TCT>TCA	p.S5S	HDX_uc011mqv.1_Silent_p.S5S|HDX_uc004eel.1_Intron	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	5	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CAGTAAATACAGAACGTAGAT	0.279	Pancreas(53;231 1169 36156 43751 51139)		NA											4	46					0	0	0.000248	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910104	101910104	+	Silent	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:101910104C>A	uc004ejj.3	+	5	2064	c.1263C>A	c.(1261-1263)GCC>GCA	p.A421A	GPRASP1_uc004eji.3_Silent_p.A421A|GPRASP1_uc010nod.2_Silent_p.A421A	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	421						cytoplasm	protein binding			ovary(1)|lung(1)	2						CAGATGAAGCCAGCATAGAGT	0.552			NA											21	88					1.96292e-10	3.3688e-10	0.001523	1	0
GPRASP1	9737	broad.mit.edu	37	X	101911166	101911166	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:101911166G>T	uc004ejj.3	+	5	3126	c.2325G>T	c.(2323-2325)GAG>GAT	p.E775D	GPRASP1_uc004eji.3_Missense_Mutation_p.E775D|GPRASP1_uc010nod.2_Missense_Mutation_p.E775D	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	775	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AAGCTGAGGAGGGGGACATTA	0.493			NA											7	177					1.06961e-07	1.68398e-07	0.00308	1	0
IL1RAPL2	26280	broad.mit.edu	37	X	104440287	104440287	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:104440287G>T	uc004elz.1	+	3	969	c.213G>T	c.(211-213)GGG>GGT	p.G71G		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	71	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AGAGCACTGGGCTCAGGCTTA	0.448			NA											26	91					3.28513e-13	6.01747e-13	0.003954	1	0
COL4A5	1287	broad.mit.edu	37	X	107827715	107827715	+	Missense_Mutation	SNP	G	G	T	rs104886092		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:107827715G>T	uc004enz.1	+	18	1194	c.992G>T	c.(991-993)GGC>GTC	p.G331V	COL4A5_uc011mso.1_Missense_Mutation_p.G331V|COL4A5_uc004eob.1_5'UTR	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	331	Triple-helical region.		G -> V (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ATTGAACAGGGCCAAAAAGGT	0.328			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				7	75					5.18039e-06	7.33728e-06	0.00308	1	0
CAPN6	827	broad.mit.edu	37	X	110490609	110490609	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:110490609G>A	uc004epc.1	-	12	1898	c.1730C>T	c.(1729-1731)CCT>CTT	p.P577L	CAPN6_uc011msu.1_Missense_Mutation_p.P322L	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	577	C2.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						TACTATAATAGGAATGTCAGT	0.423			NA											8	297					0	0	0.006214	0	0
WDR44	54521	broad.mit.edu	37	X	117543510	117543510	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:117543510A>T	uc004eqn.2	+	11	2017	c.1592A>T	c.(1591-1593)CAA>CTA	p.Q531L	WDR44_uc004eqo.2_Missense_Mutation_p.Q531L|WDR44_uc011mtr.1_Missense_Mutation_p.Q506L|WDR44_uc010nqi.2_Missense_Mutation_p.Q241L	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	531	WD 1.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						TCAGCTGGACAAGACAATGTA	0.333			NA											5	183					0	0	0.000602	0	0
ATP1B4	23439	broad.mit.edu	37	X	119505001	119505001	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:119505001C>G	uc004esr.2	+	4	582	c.498C>G	c.(496-498)AAC>AAG	p.N166K	ATP1B4_uc004esq.2_Missense_Mutation_p.N162K|ATP1B4_uc011mtx.1_Missense_Mutation_p.N131K|ATP1B4_uc011mty.1_Missense_Mutation_p.N123K	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	166	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TTAACTTCAACTTCAACGTTT	0.398			NA											9	145					0	0	0.004482	0	0
CUL4B	8450	broad.mit.edu	37	X	119668355	119668355	+	Silent	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:119668355G>T	uc004esw.2	-	19	2738	c.2301C>A	c.(2299-2301)ATC>ATA	p.I767I	CUL4B_uc010nqq.2_Silent_p.I468I|CUL4B_uc004esv.2_Silent_p.I749I	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	767					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTGCCTGCTTGATCTCTTCTA	0.388			NA											37	260					6.33695e-27	1.23183e-26	0.007835	1	0
GPR112	139378	broad.mit.edu	37	X	135430312	135430312	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:135430312G>T	uc004ezu.1	+	6	4738	c.4447G>T	c.(4447-4449)GAC>TAC	p.D1483Y	GPR112_uc010nsb.1_Missense_Mutation_p.D1278Y|GPR112_uc010nsc.1_Missense_Mutation_p.D1250Y	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1483	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGTTCTCTCCGACAGGATCAC	0.433			NA											19	233					3.57192e-18	6.83871e-18	0.006122	1	0
GABRA3	2556	broad.mit.edu	37	X	151336800	151336800	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:151336800C>A	uc010ntk.1	-	10	1619	c.1379G>T	c.(1378-1380)CGC>CTC	p.R460L		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	460	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAGATGATGCGGGAAATTTT	0.498	NSCLC(142;2578 2613 10251 16743)		NA											44	157					1.15183e-24	2.22765e-24	0.002222	1	0
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:121134166_121134168delGAA	uc001tyy.1	+	5	848_850	c.697_699delGAA	c.(697-699)GAAdel	p.E238del		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	238	Poly-Glu.|Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						gaaagaagaggaagaagaagaag	0.404			NA											8	196	---	---	---	---	NA	NA	NA	NA	NA
ACSF2	80221	broad.mit.edu	37	17	48503739	48503739	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:48503739delC	uc002iqu.2	+	1	221	c.117delC	c.(115-117)GTCfs	p.V39fs	ACSF2_uc010wml.1_Frame_Shift_Del_p.V39fs|ACSF2_uc010wmm.1_Frame_Shift_Del_p.V39fs|ACSF2_uc010wmn.1_Frame_Shift_Del_p.V39fs|ACSF2_uc010wmo.1_5'UTR	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	39					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TGCAGGGTGTCCGCTTCCTCA	0.726			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MED13	9969	broad.mit.edu	37	17	60107282	60107283	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr17:60107282_60107283delGT	uc002izo.2	-	7	1178_1179	c.1101_1102delAC	c.(1099-1104)ATACCCfs	p.I367fs	MED13_uc002izp.2_5'UTR	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	367_368					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AATTTTCTGGGTATTTTCCCAC	0.381			NA											28	85	---	---	---	---	NA	NA	NA	NA	NA
ZADH2	284273	broad.mit.edu	37	18	72920829	72920830	+	Frame_Shift_Ins	INS	-	-	C			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr18:72920829_72920830insC	uc002llx.2	-	1	452_453	c.184_185insG	c.(184-186)GACfs	p.D62fs	TSHZ1_uc002lly.2_5'Flank	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	62						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		GAGGTCTCCGTCCCCGGGGAGC	0.619			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
IFNAR2	3455	broad.mit.edu	37	21	34635338	34635338	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr21:34635338delG	uc002yrd.2	+	9	1409	c.1081delG	c.(1081-1083)GACfs	p.D361fs	IFNAR2_uc002yre.2_Frame_Shift_Del_p.D361fs|IFNAR2_uc002yrf.2_3'UTR|IL10RB_uc002yrh.1_Intron|IL10RB_uc002yri.1_Intron	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	361	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CCAGTTGATAGACCCGGAGTC	0.607			NA											14	78	---	---	---	---	NA	NA	NA	NA	NA
SLITRK3	22865	broad.mit.edu	37	3	164906357	164906357	+	Frame_Shift_Del	DEL	G	G	-	rs146211129		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr3:164906357delG	uc003fej.3	-	2	2706	c.2262delC	c.(2260-2262)CCCfs	p.P754fs	SLITRK3_uc003fek.2_Frame_Shift_Del_p.P754fs	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	754	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GCTTGTAGATGGGGTTGTTGC	0.557			NA								HNSCC(40;0.11)			18	126	---	---	---	---	NA	NA	NA	NA	NA
ERBB2IP	55914	broad.mit.edu	37	5	65349867	65349867	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr5:65349867delA	uc003juk.1	+	21	3029	c.2721delA	c.(2719-2721)GGAfs	p.G907fs	ERBB2IP_uc003jui.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc003juj.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqx.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqy.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Frame_Shift_Del_p.G903fs|ERBB2IP_uc003jul.1_Frame_Shift_Del_p.G903fs	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	907					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CTGTTGATGGAAAAAATATAG	0.378			NA											7	1553	---	---	---	---	NA	NA	NA	NA	NA
C8orf59	401466	broad.mit.edu	37	8	86129664	86129664	+	Frame_Shift_Del	DEL	T	T	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr8:86129664delT	uc010mac.1	-	3	305	c.65delA	c.(64-66)AACfs	p.N22fs	C8orf59_uc003ydd.2_Frame_Shift_Del_p.N22fs|C8orf59_uc010mad.1_Frame_Shift_Del_p.N22fs|C8orf59_uc003yde.2_Frame_Shift_Del_p.N22fs|C8orf59_uc011lfu.1_RNA	NM_001099670	NP_001093140	Q8N0T1	CH059_HUMAN	hypothetical protein LOC401466	22											0						AGCCTTAAAGTTTTTTTGGCT	0.343			NA											7	225	---	---	---	---	NA	NA	NA	NA	NA
PTPRD	5789	broad.mit.edu	37	9	8389298	8389298	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr9:8389298delC	uc003zkk.2	-	36	5031	c.4320delG	c.(4318-4320)TGGfs	p.W1440fs	PTPRD_uc003zkp.2_Frame_Shift_Del_p.W1034fs|PTPRD_uc003zkq.2_Frame_Shift_Del_p.W1033fs|PTPRD_uc003zkr.2_Frame_Shift_Del_p.W1024fs|PTPRD_uc003zks.2_Frame_Shift_Del_p.W1033fs|PTPRD_uc003zkl.2_Frame_Shift_Del_p.W1431fs|PTPRD_uc003zkm.2_Frame_Shift_Del_p.W1427fs|PTPRD_uc003zkn.2_Frame_Shift_Del_p.W1029fs|PTPRD_uc003zko.2_Frame_Shift_Del_p.W1030fs	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1440	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATATCATTCTCCAAAAGTCCC	0.403			NA								TSP Lung(15;0.13)			12	228	---	---	---	---	NA	NA	NA	NA	NA
CXorf59	286464	broad.mit.edu	37	X	36162841	36162842	+	Frame_Shift_Ins	INS	-	-	T			TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chrX:36162841_36162842insT	uc004ddk.1	+	11	1610_1611	c.1424_1425insT	c.(1423-1425)TGTfs	p.C475fs		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	475	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						ttttttgtttgtttgttctttt	0			NA											14	46	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-49-6744-01A-11D-1855-08	TCGA-49-6744-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bf6ba698-7154-4d7f-b076-24ac2f768696	2c3be991-7581-48e9-8ebb-054eedf79d45	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	12	NA	NA	NA	NA	0.00909568	0.0103446	0.000248	1	1
