Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HES4	57801	broad.mit.edu	37	1	935105	935105	+	Silent	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:935105G>C	uc001aci.2	-	2	370	c.171C>G	c.(169-171)CTC>CTG	p.L57L	HES4_uc010nyc.1_Silent_p.L83L	NM_021170	NP_066993	Q9HCC6	HES4_HUMAN	hairy and enhancer of split 4 isoform 2	57	Helix-loop-helix motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;9.36e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.41e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00237)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGAGGGTTTTGAGCTGAGCGA	0.662			NA											6	47					0	0	0.001984	0	0
VPS13D	55187	broad.mit.edu	37	1	12378268	12378268	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:12378268C>T	uc001atv.2	+	31	7429	c.7288C>T	c.(7288-7290)CGC>TGC	p.R2430C	VPS13D_uc001atw.2_Missense_Mutation_p.R2430C|VPS13D_uc001atx.2_Missense_Mutation_p.R1618C|VPS13D_uc001aty.1_Missense_Mutation_p.R168C	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2430					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TACTCCTTCTCGCCACCGTAA	0.438			NA											31	138					0	0	0.002836	0	0
UBR4	23352	broad.mit.edu	37	1	19499493	19499493	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:19499493G>C	uc001bbi.2	-	25	3390	c.3386C>G	c.(3385-3387)TCA>TGA	p.S1129*	UBR4_uc001bbm.1_Nonsense_Mutation_p.S340*	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1129					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTGGACCTTTGAGATCGCGGC	0.468			NA											6	80					0	0	0.001984	0	0
RNF19B	127544	broad.mit.edu	37	1	33402454	33402454	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:33402454C>T	uc010oho.1	-	9	2152	c.2152G>A	c.(2152-2154)GAG>AAG	p.E718K	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.E717K	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	718						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTTTGTCCCTCGGCTAGGGCA	0.567			NA											28	168					0	0	0.007291	0	0
EPHA10	284656	broad.mit.edu	37	1	38227381	38227381	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:38227381C>T	uc009vvi.2	-	3	632	c.546G>A	c.(544-546)CCG>CCA	p.P182P	EPHA10_uc001cbw.3_Silent_p.P182P	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	182	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCGGCTGAGCGGTCCGATCT	0.657			NA											5	32					0	0	0.001168	0	0
KIAA0467	23334	broad.mit.edu	37	1	43893380	43893380	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:43893380C>T	uc001cjk.1	+	11	1543	c.1081C>T	c.(1081-1083)CAG>TAG	p.Q361*		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1260						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCAGCCCCCTCAGGCGCCCCG	0.582			NA											9	26					0	0	0.006214	0	0
TM2D1	83941	broad.mit.edu	37	1	62175070	62175070	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:62175070G>C	uc001czz.1	-	3	581	c.278C>G	c.(277-279)TCC>TGC	p.S93C		NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor	93					apoptosis					ovary(1)	1						ATTGCCACTGGAATCCTTACA	0.348			NA											7	84					0	0	0.00308	0	0
CCDC18	343099	broad.mit.edu	37	1	93722039	93722039	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:93722039G>A	uc001dpq.2	+	25	4012	c.3844G>A	c.(3844-3846)GAA>AAA	p.E1282K	CCDC18_uc001dpr.1_Missense_Mutation_p.E77K	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	1163	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AGCACAGAGAGAAATAGAAAG	0.418			NA											8	91					0	0	0.004482	0	0
PTBP2	58155	broad.mit.edu	37	1	97278831	97278831	+	Splice_Site	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:97278831G>C	uc001drq.2	+	14	1713	c.1467_splice	c.e14-1	p.Q489_splice	PTBP2_uc001drn.2_Missense_Mutation_p.R495T|PTBP2_uc001dro.2_Missense_Mutation_p.R490T|PTBP2_uc010otz.1_Missense_Mutation_p.R506T|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.R438T|PTBP2_uc001drr.2_Splice_Site_p.Q494_splice|PTBP2_uc010oua.1_Missense_Mutation_p.R498T|PTBP2_uc001dru.2_Splice_Site|PTBP2_uc001drs.1_Missense_Mutation_p.R109T|PTBP2_uc001drt.2_Splice_Site_p.Q108_splice	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2								nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TGTTTCAGAAGAGATCACAAA	0.323			NA											11	98					0	0	0.000978	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858806	149858806	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:149858806G>A	uc001etd.2	+	1	282	c.282G>A	c.(280-282)CTG>CTA	p.L94L	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	94					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			ACGAGGAACTGAACAAGCTGC	0.582			NA											21	121					0	0	0.001882	0	0
DUSP27	92235	broad.mit.edu	37	1	167097145	167097145	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:167097145G>A	uc001geb.1	+	5	2777	c.2777G>A	c.(2776-2778)AGA>AAA	p.R926K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	926	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGTGGCAGCAGAGTTGGCAAA	0.488			NA											4	50					0	0	0.000248	0	0
DCAF6	55827	broad.mit.edu	37	1	167944145	167944145	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:167944145G>C	uc001gew.2	+	4	572	c.330G>C	c.(328-330)CAG>CAC	p.Q110H	DCAF6_uc001gev.2_Missense_Mutation_p.Q110H|DCAF6_uc001gex.2_Missense_Mutation_p.Q110H|DCAF6_uc010plk.1_Missense_Mutation_p.Q79H|DCAF6_uc001gey.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	110	WD 2.				positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGATAAACAGATTGTATCCT	0.373			NA											15	82					0	0	0.004007	0	0
F5	2153	broad.mit.edu	37	1	169487715	169487715	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:169487715C>G	uc001ggg.1	-	23	6425	c.6280G>C	c.(6280-6282)GAT>CAT	p.D2094H		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2094	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCCCAGTAATCTCCCCACCAA	0.463			NA											9	71					0	0	0.006214	0	0
MRPS14	63931	broad.mit.edu	37	1	174983875	174983875	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:174983875A>G	uc001gkk.2	-	3	334	c.317T>C	c.(316-318)CTT>CCT	p.L106P	MRPS14_uc009wwr.2_Missense_Mutation_p.L91P	NM_022100	NP_071383	O60783	RT14_HUMAN	mitochondrial ribosomal protein S14	106					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0						TATACGACTAAGCCTCCAGCG	0.537			NA											6	107					0	0	0.001168	0	0
CEP350	9857	broad.mit.edu	37	1	180062921	180062921	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:180062921C>G	uc001gnt.2	+	34	8064	c.7681C>G	c.(7681-7683)CAA>GAA	p.Q2561E	CEP350_uc009wxl.2_Missense_Mutation_p.Q2560E|CEP350_uc001gnv.2_Missense_Mutation_p.Q696E|CEP350_uc001gnw.1_Missense_Mutation_p.Q318E|CEP350_uc001gnx.1_Missense_Mutation_p.Q318E	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2561						centrosome|nucleus|spindle				ovary(4)	4						TGCTCCTCCTCAAAAAATATC	0.343			NA											16	90					0	0	0.004007	0	0
YOD1	55432	broad.mit.edu	37	1	207222742	207222742	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:207222742C>T	uc001hfe.1	-	2	717	c.670G>A	c.(670-672)GAG>AAG	p.E224K	PFKFB2_uc010psc.1_Intron|YOD1_uc001hff.1_Missense_Mutation_p.E180K	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	YOD1 OTU deubiquinating enzyme 1 homolog	224	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1	Prostate(682;0.19)					ATCGATATCTCTATTGCTCCT	0.403			NA											44	179					0	0	0.00361	0	0
CENPF	1063	broad.mit.edu	37	1	214816089	214816089	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:214816089G>C	uc001hkm.2	+	12	4582	c.4408G>C	c.(4408-4410)GAG>CAG	p.E1470Q		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1566	1-2.|2 X 96 AA approximate tandem repeats.		Missing.		cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GGGCTTGGAGGAGGGGCTCGT	0.478	Colon(80;575 1284 11000 14801 43496)		NA											23	51					0	0	0.00278	0	0
LEFTY1	10637	broad.mit.edu	37	1	226109325	226109325	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:226109325G>A	uc010pvj.1	-	4	493	c.338C>T	c.(337-339)GCA>GTA	p.A113V	PYCR2_uc001hpp.2_Intron|PYCR2_uc001hpq.2_Missense_Mutation_p.A187V|PYCR2_uc001hpr.2_Missense_Mutation_p.A140V			O75610	LFTY1_HUMAN	SubName: Full=cDNA FLJ54750, moderately similar to Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2);	Error:Variant_position_missing_in_O75610_after_alignment					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					ATCAGCCAATGCGTCCAGAGC	0.562			NA											10	58					0	0	0.000978	0	0
TBCE	6905	broad.mit.edu	37	1	235577809	235577809	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:235577809A>G	uc001hwz.1	+	4	370	c.247A>G	c.(247-249)ACT>GCT	p.T83A	TBCE_uc010pxq.1_RNA|TBCE_uc001hxa.1_Missense_Mutation_p.T83A|TBCE_uc010pxr.1_Missense_Mutation_p.T83A|TBCE_uc001hxb.1_5'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	83					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			AGACTTTCTTACTGCAATTAA	0.388			NA											3	122					0	0	0.000248	0	0
OR2W5	441932	broad.mit.edu	37	1	247655099	247655099	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:247655099C>T	uc001icz.1	+	1	670	c.670C>T	c.(670-672)CGC>TGC	p.R224C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGATTGCAGCCGCGGTGCTGA	0.567			NA											21	85					0	0	0.008871	0	0
OR11L1	391189	broad.mit.edu	37	1	248004717	248004717	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr1:248004717A>G	uc001idn.1	-	1	482	c.482T>C	c.(481-483)CTG>CCG	p.L161P		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGAAATCATCAGGGAAGGCAG	0.557			NA											4	132					0	0	0.000248	0	0
MARCH8	220972	broad.mit.edu	37	10	45956749	45956749	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr10:45956749G>A	uc001jci.1	-	5	592	c.353C>T	c.(352-354)TCC>TTC	p.S118F	MARCH8_uc001jch.2_Missense_Mutation_p.S400F|MARCH8_uc001jcj.1_Missense_Mutation_p.S118F|MARCH8_uc001jck.1_Missense_Mutation_p.S118F|MARCH8_uc001jcg.1_5'UTR	NM_001002266	NP_001002266	Q5T0T0	MARH8_HUMAN	cellular modulator of immune recognition isoform	118	RING-CH-type.					cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding				0						GCGCGTGTCGGAGCTCTTGAT	0.572	NSCLC(102;658 1594 2173 16344 34808)		NA											11	63					0	0	0.001855	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988655	103988655	+	Silent	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr10:103988655C>G	uc001kut.2	+	4	622	c.459C>G	c.(457-459)CTC>CTG	p.L153L		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	153					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		GCACAGTGCTCGTGTACACAA	0.498			NA											17	118					0	0	0.007413	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115609962	115609962	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr10:115609962G>C	uc001law.2	-	2	1820	c.902C>G	c.(901-903)TCT>TGT	p.S301C		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	301					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		TTGAAGTGGAGAATAGGAGAT	0.403			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					16	115					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	10	134647588	134647588	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr10:134647588C>T	uc010qux.1	-	41	6084	c.6084G>A	c.(6082-6084)TCG>TCA	p.S2028S		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						CTTTGCCCTTCGACTTCCCTG	0.522			NA											14	120					0	0	0.004007	0	0
MUC15	143662	broad.mit.edu	37	11	26584813	26584813	+	Splice_Site	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:26584813C>G	uc001mqx.2	-	3	961	c.695_splice	c.e3-1	p.E232_splice	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Splice_Site_p.E259_splice|MUC15_uc001mqy.2_Intron	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b							extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTTCTATTTTCTACAGGACaa	0.313			NA											9	58					0	0	0.004482	0	0
HIPK3	10114	broad.mit.edu	37	11	33374837	33374837	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:33374837C>T	uc001mul.1	+	17	3641	c.3371C>T	c.(3370-3372)TCA>TTA	p.S1124L	HIPK3_uc001mum.1_Missense_Mutation_p.S1103L|HIPK3_uc009yjv.1_Missense_Mutation_p.S1103L	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	1124					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TACCCATCATCAGCCACCCTC	0.517			NA											11	143					0	0	0.000978	0	0
RNF169	254225	broad.mit.edu	37	11	74546756	74546756	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:74546756G>C	uc001ovl.3	+	6	1121	c.1108G>C	c.(1108-1110)GAG>CAG	p.E370Q	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	370							zinc ion binding			ovary(1)	1						TGTCAGCCCTGAGAGCAATGA	0.532			NA											11	134					0	0	0.001368	0	0
C2CD2L	9854	broad.mit.edu	37	11	118986936	118986936	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:118986936G>A	uc001pvo.2	+	14	2450	c.2091G>A	c.(2089-2091)AAG>AAA	p.K697K	C2CD2L_uc001pvn.2_Silent_p.K698K	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	697						integral to membrane					0						CCAAACCCAAGGCCAATGGTA	0.587			NA											4	54					0	0	0.000602	0	0
GLB1L2	89944	broad.mit.edu	37	11	134240907	134240907	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:134240907C>G	uc001qhp.2	+	13	1409	c.1221C>G	c.(1219-1221)ATC>ATG	p.I407M	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	407					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGCAGCCAATCAAGTCTGAAA	0.567			NA											19	124					0	0	0.002299	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954612	10954612	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:10954612G>A	uc001qyv.2	-	1	615	c.558C>T	c.(556-558)CTC>CTT	p.L186L		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	186	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						TTGCCAGGTTGAGAAATAACT	0.448			NA											4	24					0	0	0.000248	0	0
HOXC6	3223	broad.mit.edu	37	12	54422532	54422532	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:54422532C>G	uc001sev.2	+	1	339	c.227C>G	c.(226-228)TCC>TGC	p.S76C	HOXC6_uc001ses.2_5'UTR|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	76					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.S76Y(1)		ovary(2)|upper_aerodigestive_tract(1)	3						GGATCTAATTCCTTTTACCAG	0.493			NA											15	86					0	0	0.003163	0	0
TIMELESS	8914	broad.mit.edu	37	12	56826270	56826270	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:56826270G>A	uc001slf.2	-	7	738	c.570C>T	c.(568-570)CTC>CTT	p.L190L	TIMELESS_uc001slg.2_Silent_p.L189L	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	190					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GAATCGCCCAGAGGAGCTGGT	0.557			NA											11	88					0	0	0.001855	0	0
TMTC3	160418	broad.mit.edu	37	12	88568455	88568455	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:88568455G>A	uc001tau.2	+	9	1491	c.1271G>A	c.(1270-1272)AGA>AAA	p.R424K	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	424	TPR 1.					integral to membrane	binding			skin(1)	1						ACATTCCACAGAAATTGGGAT	0.343			NA											13	117					0	0	0.001855	0	0
APAF1	317	broad.mit.edu	37	12	99056294	99056294	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:99056294G>A	uc001tfz.2	+	6	1348	c.771G>A	c.(769-771)CAG>CAA	p.Q257Q	APAF1_uc001tfy.2_Silent_p.Q246Q|APAF1_uc001tga.2_Silent_p.Q246Q|APAF1_uc001tgb.2_Silent_p.Q257Q|APAF1_uc001tgc.2_Silent_p.Q257Q	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	257	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TTGACAGTCAGTGTCAGATTC	0.308			NA											16	91					0	0	0.008871	0	0
ACTR6	64431	broad.mit.edu	37	12	100617685	100617685	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:100617685G>C	uc001thb.1	+	11	1239	c.1183G>C	c.(1183-1185)GAT>CAT	p.D395H	ACTR6_uc001thc.1_Missense_Mutation_p.D287H|ACTR6_uc001thd.1_Missense_Mutation_p.D375H|ACTR6_uc009ztu.1_Intron|ACTR6_uc001the.1_Missense_Mutation_p.D313H|ACTR6_uc001thf.1_Missense_Mutation_p.D293H|uc001thg.1_5'Flank	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	395						cytoplasm|cytoskeleton				ovary(1)	1						AGAGAAATTTGATATTTAAGC	0.318			NA											7	86					0	0	0.001984	0	0
UTP20	27340	broad.mit.edu	37	12	101761655	101761655	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:101761655G>A	uc001tia.1	+	48	6441	c.6285G>A	c.(6283-6285)CTG>CTA	p.L2095L		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2095					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ATCTGAGTCTGAAGACTTCCA	0.438			NA											12	161					0	0	0.003163	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123687489	123687489	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr12:123687489G>A	uc001uel.2	-	6	1114	c.1007C>T	c.(1006-1008)TCT>TTT	p.S336F	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	336					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GTCTATGTCAGAGGGACTAGA	0.458			NA											13	123					0	0	0.001855	0	0
LATS2	26524	broad.mit.edu	37	13	21549028	21549028	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr13:21549028C>T	uc009zzs.2	-	8	3613	c.3248G>A	c.(3247-3249)TGC>TAC	p.C1083Y	LATS2_uc001unr.3_Missense_Mutation_p.C1083Y	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	1083					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CACAGGCTGGCAGCCTTCAGT	0.602			NA											11	41					0	0	0.000978	0	0
MTUS2	23281	broad.mit.edu	37	13	30075296	30075296	+	Silent	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr13:30075296C>G	uc001usl.3	+	13	3949	c.3891C>G	c.(3889-3891)CTC>CTG	p.L1297L	MTUS2_uc001usm.3_Silent_p.L266L|MTUS2_uc010aau.2_Silent_p.L176L|MTUS2_uc010tdq.1_Silent_p.L49L	NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	1287	Potential.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						ACGAAGACCTCAAAGCAAGGA	0.443			NA											12	69					0	0	0.001855	0	0
TM9SF2	9375	broad.mit.edu	37	13	100153956	100153956	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr13:100153956G>A	uc001voj.1	+	1	229	c.96G>A	c.(94-96)CGG>CGA	p.R32R	TM9SF2_uc010afz.1_Silent_p.R32R	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	32	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GCCCGCGCCGGAGCGGCGCTT	0.667			NA											7	61					0	0	0.001984	0	0
NALCN	259232	broad.mit.edu	37	13	101997671	101997671	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr13:101997671C>G	uc001vox.1	-	7	934	c.745G>C	c.(745-747)GAA>CAA	p.E249Q	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.E249Q|NALCN_uc001vpa.2_Missense_Mutation_p.E249Q	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	249	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCCAGATCTTCAAGGTCCATG	0.433			NA											14	133					0	0	0.00245	0	0
FAM155A	728215	broad.mit.edu	37	13	108518943	108518943	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr13:108518943A>G	uc001vql.2	-	1	518	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	1						integral to membrane	binding			skin(1)	1						ACCCCTGGTCATATTTTGGGA	0.532			NA											9	77					0	0	0.004482	0	0
SLC7A7	9056	broad.mit.edu	37	14	23242848	23242848	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:23242848G>C	uc001wgr.3	-	10	1645	c.1507C>G	c.(1507-1509)CCC>GCC	p.P503A	SLC7A7_uc001wgs.3_Missense_Mutation_p.P503A|SLC7A7_uc001wgt.3_Missense_Mutation_p.P503A|SLC7A7_uc001wgu.3_Missense_Mutation_p.P503A|SLC7A7_uc001wgv.3_Missense_Mutation_p.P503A	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	503					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		CGTTGCTTGGGCATCTCTCCT	0.473			NA											7	62					0	0	0.001984	0	0
MYH6	4624	broad.mit.edu	37	14	23868018	23868018	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:23868018C>G	uc001wjv.2	-	15	1877	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	604	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACAACAGTCTCGTTGAGAGGA	0.567			NA											6	63					0	0	0.001168	0	0
RNF31	55072	broad.mit.edu	37	14	24619469	24619469	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:24619469G>C	uc001wmn.1	+	7	1258	c.1009G>C	c.(1009-1011)GAG>CAG	p.E337Q	RNF31_uc001wml.1_Missense_Mutation_p.E186Q|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E152Q|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	337	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GTTGGGAACTGAGGGTCCCCA	0.602			NA											3	35					0	0	0.004672	0	0
HECTD1	25831	broad.mit.edu	37	14	31576369	31576369	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:31576369C>T	uc001wrc.1	-	38	7198	c.6709G>A	c.(6709-6711)GAG>AAG	p.E2237K	HECTD1_uc001wra.1_Missense_Mutation_p.E363K|HECTD1_uc001wrb.1_Missense_Mutation_p.E363K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2237	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTTTCAAGCTCATCACTATCC	0.393			NA											7	62					0	0	0.001984	0	0
AKAP6	9472	broad.mit.edu	37	14	33242896	33242896	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:33242896G>T	uc001wrq.2	+	12	3555	c.3385G>T	c.(3385-3387)GAA>TAA	p.E1129*	uc001wrr.2_5'Flank	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1129	Spectrin 2.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CCTCTGTCGTGAAATCAAGCA	0.458	Melanoma(49;821 1200 7288 13647 42351)		NA											21	145					1.77063e-15	2.437e-15	0.005443	1	0
SYNE2	23224	broad.mit.edu	37	14	64630120	64630120	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:64630120G>C	uc001xgm.2	+	89	16530	c.16300G>C	c.(16300-16302)GAG>CAG	p.E5434Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E5434Q|SYNE2_uc010apy.2_Missense_Mutation_p.E1819Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E396Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5434	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCTTCTGCAGGAGCTGCAGCA	0.493			NA											8	47					0	0	0.004482	0	0
DCAF5	8816	broad.mit.edu	37	14	69520961	69520961	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr14:69520961C>T	uc001xkp.2	-	9	2661	c.2442G>A	c.(2440-2442)AGG>AGA	p.R814R	DCAF5_uc001xkq.2_Silent_p.R813R	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	814						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						CAGACTGGGTCCTGGGACAGT	0.592			NA											4	36					0	0	0.000248	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22840267	22840267	+	Silent	SNP	G	G	C	rs140377004	by1000genomes	TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:22840267G>C	uc001yur.3	+	4	463	c.333G>C	c.(331-333)CTG>CTC	p.L111L	TUBGCP5_uc001yuq.2_Silent_p.L111L	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	111					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		ATTCCATACTGTCACTTCTTC	0.363			NA											15	118					0	0	0.006122	0	0
ZNF609	23060	broad.mit.edu	37	15	64792238	64792238	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:64792238G>A	uc002ann.2	+	1	620	c.620G>A	c.(619-621)GGA>GAA	p.G207E	ZNF609_uc010bgy.2_Missense_Mutation_p.G207E	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	207						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GTGGATACAGGAGCTGTGGAG	0.572			NA											4	38					0	0	0.000248	0	0
IL16	3603	broad.mit.edu	37	15	81589336	81589336	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:81589336C>T	uc002bgh.3	+	13	2346	c.1970C>T	c.(1969-1971)TCT>TTT	p.S657F	IL16_uc010blq.1_Missense_Mutation_p.S611F|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.S699F|IL16_uc002bgg.2_Missense_Mutation_p.S657F|IL16_uc002bgi.1_Missense_Mutation_p.S47F|IL16_uc002bgj.2_Missense_Mutation_p.S151F|IL16_uc002bgk.2_5'UTR|IL16_uc002bgl.1_5'UTR|IL16_uc010unq.1_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	657					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CCTAGTGCCTCTGCCGGCTGC	0.592			NA											6	22					0	0	0.001168	0	0
HOMER2	9455	broad.mit.edu	37	15	83520967	83520967	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:83520967C>T	uc002bjg.2	-	7	908	c.722G>A	c.(721-723)AGA>AAA	p.R241K	HOMER2_uc002bjh.2_Missense_Mutation_p.R230K|HOMER2_uc002bjj.2_Missense_Mutation_p.R175K|HOMER2_uc002bji.2_Missense_Mutation_p.R186K	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	241	Potential.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						CTCCTTCTCTCTGTTGATCTC	0.502			NA											3	55					0	0	0.004672	0	0
FANCI	55215	broad.mit.edu	37	15	89836071	89836071	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:89836071G>C	uc010bnp.1	+	21	2235	c.2145G>C	c.(2143-2145)AAG>AAC	p.K715N	FANCI_uc002bnm.1_Missense_Mutation_p.K715N|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.K536N|FANCI_uc002bnq.1_Missense_Mutation_p.K128N	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	715					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAATGATTAAGAGTGAGCTGG	0.299			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				10	111					0	0	0.008291	0	0
BLM	641	broad.mit.edu	37	15	91310173	91310173	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:91310173G>A	uc002bpr.2	+	10	2324	c.2227G>A	c.(2227-2229)GAC>AAC	p.D743N	BLM_uc010uqh.1_Missense_Mutation_p.D743N|BLM_uc010uqi.1_Missense_Mutation_p.D368N|BLM_uc010bnx.2_Missense_Mutation_p.D743N|BLM_uc002bps.1_Missense_Mutation_p.D305N	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	743	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TGATAAGACTGACTCAGAAGC	0.284			NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				9	74					0	0	0.008291	0	0
TARSL2	123283	broad.mit.edu	37	15	102211689	102211689	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr15:102211689C>T	uc002bxm.2	-	15	2022	c.1967G>A	c.(1966-1968)AGT>AAT	p.S656N	TARSL2_uc002bxl.2_Missense_Mutation_p.S201N|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	656					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATCACTCACCTAACATATGT	0.299			NA											15	102					0	0	0.00245	0	0
DCI	1632	broad.mit.edu	37	16	2296868	2296868	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:2296868G>A	uc002cpr.2	-	3	322	c.286C>T	c.(286-288)CTG>TTG	p.L96L	DCI_uc002cps.2_Silent_p.L96L	NM_001919	NP_001910	P42126	ECI1_HUMAN	dodecenoyl-Coenzyme A delta isomerase precursor	96					fatty acid beta-oxidation	mitochondrial matrix	dodecenoyl-CoA delta-isomerase activity				0						ACCGAGGTCAGAATGACACCG	0.572			NA											12	64					0	0	0.001368	0	0
ABCA3	21	broad.mit.edu	37	16	2331082	2331082	+	Silent	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:2331082G>C	uc002cpy.1	-	28	5017	c.4305C>G	c.(4303-4305)CTC>CTG	p.L1435L	ABCA3_uc010bsk.1_Silent_p.L1377L	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1435	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCCCAGAAGTGAGGCTCTCCT	0.602			NA											3	51					0	0	0.004672	0	0
TFAP4	7023	broad.mit.edu	37	16	4312331	4312331	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:4312331G>A	uc010uxg.1	-	3	602	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	116	Leucine-zipper 1.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GCACCTGGATGAAGCGCTTGA	0.507			NA											11	77					0	0	0.001368	0	0
TFAP4	7023	broad.mit.edu	37	16	4312570	4312570	+	Silent	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:4312570G>T	uc010uxg.1	-	2	476	c.222C>A	c.(220-222)CTC>CTA	p.L74L		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	74	Helix-loop-helix motif.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGTGGGGGATGAGGGTCTTGA	0.637			NA											11	94					3.07112e-06	4.18195e-06	0.000978	1	0
MGRN1	23295	broad.mit.edu	37	16	4715113	4715113	+	Silent	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:4715113G>T	uc002cwz.2	+	7	775	c.639G>T	c.(637-639)GTG>GTT	p.V213V	MGRN1_uc002cxa.2_Silent_p.V213V|MGRN1_uc010btx.2_Silent_p.V214V|MGRN1_uc010btw.2_Silent_p.V214V|MGRN1_uc002cxb.2_Silent_p.V213V|MGRN1_uc010uxo.1_Silent_p.V213V|MGRN1_uc010uxp.1_Silent_p.V213V|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	213					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TGGTGGAAGTGACTGGCCACG	0.652			NA											5	50					5.18039e-06	7.01683e-06	0.00308	1	0
SEC14L5	9717	broad.mit.edu	37	16	5056047	5056047	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:5056047G>T	uc002cye.2	+	12	1615	c.1435G>T	c.(1435-1437)GTG>TTG	p.V479L		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	479	CRAL-TRIO.					integral to membrane|intracellular	transporter activity				0						GGGAGAGAGTGTGGTGAGGCT	0.602			NA											5	38					1.23904e-05	1.6607e-05	0.000602	1	0
UMOD	7369	broad.mit.edu	37	16	20348643	20348643	+	Silent	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:20348643G>C	uc002dgz.2	-	8	1839	c.1710C>G	c.(1708-1710)CTC>CTG	p.L570L	UMOD_uc002dha.2_Silent_p.L570L|UMOD_uc002dhb.2_Silent_p.L603L	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	570	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TGGTGTCACAGAGATAGACTT	0.493			NA											7	38					0	0	0.00308	0	0
SLC5A11	115584	broad.mit.edu	37	16	24902236	24902236	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:24902236C>G	uc002dmu.2	+	9	943	c.711C>G	c.(709-711)TTC>TTG	p.F237L	SLC5A11_uc002dms.2_Missense_Mutation_p.F173L|SLC5A11_uc010vcd.1_Missense_Mutation_p.F202L|SLC5A11_uc002dmt.2_Intron|SLC5A11_uc010vce.1_Missense_Mutation_p.F167L|SLC5A11_uc010bxt.2_Missense_Mutation_p.F173L	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	237	Extracellular (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		AGAAGTACTTCTTGGCCCTGG	0.542			NA											27	170					0	0	0.004656	0	0
ITGAX	3687	broad.mit.edu	37	16	31374654	31374654	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:31374654C>T	uc002ebu.1	+	14	1736	c.1669C>T	c.(1669-1671)CAC>TAC	p.H557Y	ITGAX_uc002ebt.2_Missense_Mutation_p.H557Y|ITGAX_uc010vfk.1_Missense_Mutation_p.H207Y	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	557	Extracellular (Potential).|FG-GAP 6.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTACCTGTTTCACGGAGTCTT	0.612			NA											12	158					0	0	0.001855	0	0
ACD	65057	broad.mit.edu	37	16	67691946	67691946	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:67691946C>T	uc002etq.3	-	10	1744	c.1407G>A	c.(1405-1407)CGG>CGA	p.R469R	ACD_uc002etp.3_Silent_p.R466R|ACD_uc002etr.3_Silent_p.R466R|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	469					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GAAAAGGCGGCCGATTCTTGC	0.612			NA											6	59					0	0	0.001168	0	0
ATMIN	23300	broad.mit.edu	37	16	81078195	81078195	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr16:81078195G>A	uc002ffz.1	+	4	2110	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	ATMIN_uc002fga.2_Missense_Mutation_p.E540K|ATMIN_uc010vnn.1_Missense_Mutation_p.E469K|ATMIN_uc002fgb.1_Missense_Mutation_p.E540K	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	698					response to DNA damage stimulus	nucleus	zinc ion binding				0						CTTAGGCCTTGAGATGTTTGA	0.453			NA											25	217					0	0	0.00632	0	0
WDR81	124997	broad.mit.edu	37	17	1640965	1640965	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:1640965C>T	uc002fti.2	+	10	2392	c.2131C>T	c.(2131-2133)CGC>TGC	p.R711C	WDR81_uc002fth.2_Missense_Mutation_p.R887C|WDR81_uc010vqp.1_Missense_Mutation_p.R735C|WDR81_uc002ftj.2_Missense_Mutation_p.R1938C|WDR81_uc010vqq.1_Missense_Mutation_p.R569C	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	711										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGGGGTTATCCGCCTCCTGGC	0.642			NA											4	25					0	0	0.000248	0	0
ALOX15B	247	broad.mit.edu	37	17	7942594	7942594	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:7942594C>T	uc002gju.2	+	1	237	c.121C>T	c.(121-123)CTC>TTC	p.L41F	ALOX15B_uc002gjv.2_Missense_Mutation_p.L41F|ALOX15B_uc002gjw.2_Missense_Mutation_p.L41F|ALOX15B_uc010vun.1_Missense_Mutation_p.L41F|ALOX15B_uc010cnp.2_5'UTR	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	41	PLAT.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						CCTGGACAATCTCGGCAAGGA	0.652			NA											13	56					0	0	0.00499	0	0
SUPT6H	6830	broad.mit.edu	37	17	27016441	27016441	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:27016441G>A	uc002hby.2	+	25	3294	c.3204G>A	c.(3202-3204)AAG>AAA	p.K1068K	SUPT6H_uc010crt.2_Silent_p.K1068K|SUPT6H_uc002hbz.1_5'UTR	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1068					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GGGCTAGGAAGATGGCAGTGG	0.498			NA											7	75					0	0	0.001984	0	0
PCGF2	7703	broad.mit.edu	37	17	36895840	36895840	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:36895840T>A	uc002hqp.1	-	4	451	c.208A>T	c.(208-210)AGG>TGG	p.R70W	PCGF2_uc002hqn.1_Missense_Mutation_p.R70W|PCGF2_uc002hqo.1_Missense_Mutation_p.R70W|PCGF2_uc010cvo.1_5'UTR|PCGF2_uc002hqq.1_Missense_Mutation_p.R70W	NM_007144	NP_009075	P35227	PCGF2_HUMAN	ring finger protein 110	70					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2	Breast(7;9.07e-22)					CAAGCCCACCTGATGCTCAGC	0.622			NA											8	82					0	0	0.004482	0	0
PCGF2	7703	broad.mit.edu	37	17	36895846	36895846	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:36895846T>C	uc002hqp.1	-	4	445	c.202A>G	c.(202-204)AGC>GGC	p.S68G	PCGF2_uc002hqn.1_Missense_Mutation_p.S68G|PCGF2_uc002hqo.1_Missense_Mutation_p.S68G|PCGF2_uc010cvo.1_5'UTR|PCGF2_uc002hqq.1_Missense_Mutation_p.S68G	NM_007144	NP_009075	P35227	PCGF2_HUMAN	ring finger protein 110	68					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2	Breast(7;9.07e-22)					CACCTGATGCTCAGCAGCGGC	0.627			NA											7	91					0	0	0.00308	0	0
KRT28	162605	broad.mit.edu	37	17	38953259	38953259	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:38953259G>C	uc002hvh.1	-	5	953	c.887C>G	c.(886-888)TCA>TGA	p.S296*		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	296	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGCTGCGCCTGAGTCGTGGGA	0.662	Melanoma(19;789 869 15380 26882 39836)		NA											8	53					0	0	0.00308	0	0
KRT13	3860	broad.mit.edu	37	17	39658760	39658760	+	Silent	SNP	G	G	A	rs147022064		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:39658760G>A	uc002hwu.1	-	6	1173	c.1110C>T	c.(1108-1110)ATC>ATT	p.I370I	KRT13_uc002hwv.1_Silent_p.I370I|KRT13_uc002hww.2_Silent_p.I263I|KRT13_uc010wfr.1_Silent_p.I263I|KRT13_uc010cxo.2_Silent_p.I370I|KRT13_uc002hwx.1_Silent_p.I358I	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	370	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCTGGGCCTCGATGCTGCTGA	0.602			NA											14	102					0	0	0.00245	0	0
SC65	10609	broad.mit.edu	37	17	39967121	39967121	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:39967121T>A	uc002hxt.2	-	3	1065	c.781A>T	c.(781-783)ATA>TTA	p.I261L	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.I352L	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	261					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		ATACCTGCTATGGCCGGGTAG	0.637			NA											4	23					0	0	0.000248	0	0
AMZ2	51321	broad.mit.edu	37	17	66250612	66250612	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:66250612G>A	uc002jgs.1	+	6	771	c.654G>A	c.(652-654)GTG>GTA	p.V218V	AMZ2_uc002jgr.1_Silent_p.V218V|AMZ2_uc002jgt.1_Silent_p.V218V|AMZ2_uc002jgu.1_Silent_p.V218V|AMZ2_uc002jgv.1_Silent_p.V218V|AMZ2_uc002jgw.1_Silent_p.V160V|AMZ2_uc002jgy.1_Silent_p.V218V	NM_001033572	NP_001028744	Q86W34	AMZ2_HUMAN	archaemetzincins-2 isoform 1	218							metallopeptidase activity|zinc ion binding				0	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAGGCAAAGTGAAGAAGCTCA	0.358			NA											10	62					0	0	0.008291	0	0
SLC16A5	9121	broad.mit.edu	37	17	73089889	73089889	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:73089889C>G	uc002jmr.2	+	3	530	c.158C>G	c.(157-159)TCT>TGT	p.S53C	SLC16A5_uc002jms.1_Missense_Mutation_p.S53C|SLC16A5_uc002jmt.2_Missense_Mutation_p.S53C|SLC16A5_uc002jmu.2_Missense_Mutation_p.S53C|SLC16A5_uc010wrt.1_Missense_Mutation_p.S93C	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	53	Extracellular (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	AGCGAGACCTCTTGGTTCCCC	0.607			NA											7	137					0	0	0.001855	0	0
SLC16A5	9121	broad.mit.edu	37	17	73089908	73089908	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:73089908C>T	uc002jmr.2	+	3	549	c.177C>T	c.(175-177)CTC>CTT	p.L59L	SLC16A5_uc002jms.1_Silent_p.L59L|SLC16A5_uc002jmt.2_Silent_p.L59L|SLC16A5_uc002jmu.2_Silent_p.L59L|SLC16A5_uc010wrt.1_Silent_p.L99L	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	59	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	CCTCCATCCTCACGGCTGTGC	0.597			NA											7	132					0	0	0.008291	0	0
KIAA0802	23255	broad.mit.edu	37	18	8806923	8806923	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr18:8806923C>G	uc002knr.2	+	11	2611	c.2469C>G	c.(2467-2469)TTC>TTG	p.F823L	KIAA0802_uc002knq.2_Missense_Mutation_p.F782L|KIAA0802_uc002kns.2_Missense_Mutation_p.F153L	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1133											0						TCAGCGCCTTCAAGGCCTTGC	0.597			NA											5	26					0	0	0.000602	0	0
GRP	2922	broad.mit.edu	37	18	56897691	56897691	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr18:56897691C>G	uc002lhv.2	+	3	536	c.438C>G	c.(436-438)AAC>AAG	p.N146K	GRP_uc002lhu.2_3'UTR|GRP_uc002lhw.2_Missense_Mutation_p.N139K	NM_002091	NP_002082	P07492	GRP_HUMAN	gastrin-releasing peptide isoform 1	146					neuropeptide signaling pathway	extracellular space	neuropeptide hormone activity				0		Colorectal(73;0.0946)				CCCAGCTGAACCAGCAATGAT	0.438			NA											11	102					0	0	0.000978	0	0
CDH19	28513	broad.mit.edu	37	18	64172164	64172164	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr18:64172164G>A	uc002lkc.1	-	12	2342	c.2204C>T	c.(2203-2205)TCC>TTC	p.S735F	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	735	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TGATTCTAAGGAGCTCAGGGA	0.463			NA											10	63					0	0	0.006214	0	0
LONP1	9361	broad.mit.edu	37	19	5696170	5696170	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:5696170G>C	uc002mcx.2	-	13	1941	c.1908C>G	c.(1906-1908)ATC>ATG	p.I636M	LONP1_uc002mcy.2_Missense_Mutation_p.I572M|LONP1_uc010duh.2_Missense_Mutation_p.I377M|LONP1_uc010dui.2_Missense_Mutation_p.I620M|LONP1_uc002mcz.2_Missense_Mutation_p.I440M	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	636					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						TGGCCGTGCAGATGAACAGCA	0.662			NA											5	96					0	0	0.001168	0	0
MCOLN1	57192	broad.mit.edu	37	19	7593840	7593840	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:7593840T>C	uc002mgo.2	+	9	1243	c.1118T>C	c.(1117-1119)ATC>ACC	p.I373T	MCOLN1_uc002mgp.2_Missense_Mutation_p.I338T	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	373					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						ATCATGAAGATCGGCATCGAG	0.632			NA											4	41					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9074892	9074892	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:9074892G>A	uc002mkp.2	-	3	12758	c.12554C>T	c.(12553-12555)TCT>TTT	p.S4185F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4187	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGGAGTAGAGGAGGGACT	0.502			NA											9	85					0	0	0.006214	0	0
PRDX2	7001	broad.mit.edu	37	19	12911999	12911999	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:12911999T>A	uc002mvd.2	-	2	227	c.77A>T	c.(76-78)AAA>ATA	p.K26I	PRDX2_uc002mve.1_Missense_Mutation_p.K26I	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	26	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						CTTCACCTCTTTGAAGGCGCC	0.637			NA											5	18					0	0	0.001984	0	0
IL27RA	9466	broad.mit.edu	37	19	14143202	14143202	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:14143202C>A	uc002mxx.2	+	2	528	c.105C>A	c.(103-105)AGC>AGA	p.S35R		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	35	Extracellular (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CTCCAGGCAGCGCCGGGCCAC	0.632	Colon(164;1849 1896 4443 37792 47834)		NA											8	103					0.00621372	0.00815749	0.006214	1	0
ZNF253	56242	broad.mit.edu	37	19	20002899	20002899	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:20002899G>C	uc002noj.2	+	4	935	c.843G>C	c.(841-843)GAG>GAC	p.E281D	ZNF253_uc002nok.2_Missense_Mutation_p.E205D|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	281				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATACTGGAGAGAAACCCTACA	0.413			NA											7	75					0	0	0.001984	0	0
KLK2	3817	broad.mit.edu	37	19	51378047	51378047	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:51378047G>T	uc002ptv.2	+	2	158	c.117G>T	c.(115-117)CAG>CAT	p.Q39H	KLK2_uc010eog.2_Intron|KLK2_uc010yck.1_Missense_Mutation_p.Q39H|KLK2_uc002ptu.2_Missense_Mutation_p.Q39H|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Translation_Start_Site|KLK2_uc010ycm.1_Intron|KLK2_uc010eoh.2_5'Flank	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	39	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		AACCCTGGCAGGTGGCTGTGT	0.617			NA	T	ETV4	prostate								13	43					1.49906e-05	1.99875e-05	0.00245	1	0
TMEM190	147744	broad.mit.edu	37	19	55889060	55889060	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:55889060G>C	uc002qkt.1	+	3	212	c.194G>C	c.(193-195)GGG>GCG	p.G65A		NM_139172	NP_631911	Q8WZ59	TM190_HUMAN	transmembrane protein 190 precursor	65	P-type.|Extracellular (Potential).					integral to membrane					0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TACCGCAATGGGGTCTGCTAC	0.692			NA											8	56					0	0	0.00308	0	0
DDX1	1653	broad.mit.edu	37	2	15758387	15758387	+	Missense_Mutation	SNP	G	G	C	rs146515867		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:15758387G>C	uc002rce.2	+	16	1487	c.1199G>C	c.(1198-1200)AGA>ACA	p.R400T	DDX1_uc010yjq.1_Missense_Mutation_p.R308T	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	400	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GATGGAAAAAGACTTCAGGTA	0.259			NA											21	245					0	0	0.00278	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655752	40655752	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:40655752C>G	uc002rrx.2	-	1	1693	c.1669G>C	c.(1669-1671)GAG>CAG	p.E557Q	SLC8A1_uc002rry.2_Missense_Mutation_p.E557Q|SLC8A1_uc002rrz.2_Missense_Mutation_p.E557Q|SLC8A1_uc002rsa.2_Missense_Mutation_p.E557Q|SLC8A1_uc002rsd.3_Missense_Mutation_p.E557Q|SLC8A1_uc002rsb.1_Missense_Mutation_p.E557Q|SLC8A1_uc010fan.1_Missense_Mutation_p.E557Q|SLC8A1_uc002rsc.1_Missense_Mutation_p.E557Q	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	557	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACTTTCACCTCCATGATGCCA	0.458			NA											14	166					0	0	0.004007	0	0
MTIF2	4528	broad.mit.edu	37	2	55463886	55463886	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:55463886G>A	uc002ryn.2	-	17	2819	c.2082C>T	c.(2080-2082)CTC>CTT	p.L694L	MTIF2_uc010yox.1_Silent_p.L363L|MTIF2_uc002ryo.2_Silent_p.L694L	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	694					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						CATCTAAACTGAGACCACAAT	0.333			NA											5	52					0	0	0.000602	0	0
SMYD1	150572	broad.mit.edu	37	2	88402637	88402637	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:88402637G>A	uc002ssr.2	+	7	951	c.949G>A	c.(949-951)GAC>AAC	p.D317N	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.D13N	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGAAAAGATAGACAAGGCTCG	0.458			NA											6	63					0	0	0.001984	0	0
RGPD4	285190	broad.mit.edu	37	2	108487524	108487524	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:108487524G>C	uc010ywk.1	+	20	3146	c.3064G>C	c.(3064-3066)GAG>CAG	p.E1022Q	RGPD4_uc002tdu.2_Missense_Mutation_p.E209Q|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1022					intracellular transport		binding			skin(2)	2						CGGTGACTTTGAGAAAGATGA	0.388			NA											46	390					0	0	0.00361	0	0
PLCL1	5334	broad.mit.edu	37	2	198948761	198948761	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:198948761A>C	uc010fsp.2	+	2	811	c.520A>C	c.(520-522)ACA>CCA	p.T174P	PLCL1_uc002uuv.3_Missense_Mutation_p.T95P	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	174	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAACACGGAAACATTTAGAAA	0.458			NA											4	153					0	0	0.000248	0	0
CYP27A1	1593	broad.mit.edu	37	2	219677453	219677453	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr2:219677453G>T	uc002viz.3	+	4	1259	c.825G>T	c.(823-825)TGG>TGT	p.W275C		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	275					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGGATGGTTGGAATGCCATCT	0.567			NA											30	199					3.80469e-20	5.29349e-20	0.001786	1	0
BPIL1	80341	broad.mit.edu	37	20	31609588	31609588	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:31609588G>C	uc002wyj.2	+	15	1512	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	440						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						TGTCGCCCCTGAGATCTTTGT	0.567			NA											9	82					0	0	0.008291	0	0
ITCH	83737	broad.mit.edu	37	20	33068500	33068500	+	Missense_Mutation	SNP	A	A	G	rs139633287		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:33068500A>G	uc010geu.1	+	20	2230	c.2038A>G	c.(2038-2040)ATT>GTT	p.I680V	ITCH_uc002xak.2_Missense_Mutation_p.I639V|ITCH_uc010zuj.1_Missense_Mutation_p.I529V	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	680	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TTTAGAATCTATTGATCCAGA	0.323			NA											16	116					0	0	0.00499	0	0
GSS	2937	broad.mit.edu	37	20	33519152	33519152	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:33519152C>G	uc002xbg.2	-	11	1178	c.1098G>C	c.(1096-1098)CAG>CAC	p.Q366H	GSS_uc010zun.1_Missense_Mutation_p.Q238H|GSS_uc010zuo.1_Missense_Mutation_p.Q255H|GSS_uc010zup.1_Missense_Mutation_p.Q297H|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Missense_Mutation_p.Q96H	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	366	ATP.				nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	CACCCTCTCTCTGGGGCTTTA	0.587			NA											5	51					0	0	0.000602	0	0
DDX27	55661	broad.mit.edu	37	20	47841720	47841720	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:47841720C>T	uc002xuh.2	+	6	738	c.677C>T	c.(676-678)TCC>TTC	p.S226F		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	226	Q motif.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATGAACCTTTCCCGCCCTCTT	0.303			NA											18	119					0	0	0.001523	0	0
ADNP	23394	broad.mit.edu	37	20	49510947	49510947	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:49510947C>G	uc002xvt.1	-	5	649	c.304G>C	c.(304-306)GAA>CAA	p.E102Q	ADNP_uc002xvu.1_Missense_Mutation_p.E102Q	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	102						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ATCCTATTTTCAAAGTCTTCA	0.413			NA											11	79					0	0	0.001368	0	0
RTEL1	51750	broad.mit.edu	37	20	62324308	62324308	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr20:62324308C>T	uc002yfu.1	+	29	3146	c.2803C>T	c.(2803-2805)CTC>TTC	p.L935F	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.L935F|RTEL1_uc011abd.1_Missense_Mutation_p.L959F|RTEL1_uc011abe.1_Missense_Mutation_p.L712F|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.L180F|TNFRSF6B_uc002yfy.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	935					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GGCCGCCTGTCTCGGCCCCCT	0.652			NA											13	140					0	0	0.003163	0	0
PKNOX1	5316	broad.mit.edu	37	21	44445025	44445025	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr21:44445025G>A	uc002zcq.1	+	9	1082	c.894G>A	c.(892-894)CAG>CAA	p.Q298Q	PKNOX1_uc002zcp.1_Silent_p.Q298Q|PKNOX1_uc011aex.1_Silent_p.Q181Q	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	298	Homeobox; TALE-type.						sequence-specific DNA binding			large_intestine(2)	2						TTGCTGCTCAGACAAATTTGA	0.438			NA											9	45					0	0	0.008291	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072712	17072712	+	Silent	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr22:17072712G>T	uc002zlp.1	-	1	989	c.729C>A	c.(727-729)CTC>CTA	p.L243L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	243					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGCAAGCAAAGAGAGCCACCC	0.542			NA											14	86					9.31168e-06	1.25463e-05	0.001855	1	0
LGALS2	3957	broad.mit.edu	37	22	37966318	37966318	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr22:37966318C>T	uc003ata.2	-	4	463	c.351G>A	c.(349-351)CTG>CTA	p.L117L		NM_006498	NP_006489	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	117	Galectin.									breast(1)|skin(1)	2	Melanoma(58;0.0574)					CCCTTACGCTCAGGTAGCTCA	0.502	GBM(193;1840 2185 13711 20676 24505)		NA											16	118					0	0	0.006122	0	0
MYD88	4615	broad.mit.edu	37	3	38180462	38180462	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:38180462G>C	uc003chx.2	+	1	494	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	ACAA1_uc003cht.2_5'Flank|ACAA1_uc003chu.2_5'Flank|ACAA1_uc010hgy.2_5'Flank|ACAA1_uc010hgz.2_5'Flank|ACAA1_uc003chv.2_5'Flank|MYD88_uc011ayh.1_Missense_Mutation_p.E104Q|MYD88_uc011ayi.1_Missense_Mutation_p.E104Q|MYD88_uc011ayj.1_Missense_Mutation_p.E104Q|MYD88_uc011ayk.1_Missense_Mutation_p.E104Q|MYD88_uc011ayl.1_Missense_Mutation_p.E104Q	NM_002468	NP_002459	Q99836	MYD88_HUMAN	myeloid differentiation primary response gene	91	Death.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(93)|breast(1)	94				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCGACTGCTCGAGCTGCTTAC	0.667			NA	Mis 		ABC-DLBCL								4	47					0	0	0.000248	0	0
NKTR	4820	broad.mit.edu	37	3	42679413	42679413	+	Silent	SNP	T	T	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:42679413T>C	uc003clo.2	+	13	2364	c.2217T>C	c.(2215-2217)AGT>AGC	p.S739S	NKTR_uc003clm.1_Silent_p.S486S|NKTR_uc003clp.2_Silent_p.S486S|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Silent_p.S629S|NKTR_uc003clr.1_Silent_p.S486S|NKTR_uc003cls.2_Silent_p.S439S	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	739	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CACAGTGTAGTAGATCATCTT	0.378			NA											3	59					0	0	0.004672	0	0
C3orf63	23272	broad.mit.edu	37	3	56667420	56667420	+	Silent	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:56667420G>C	uc003did.3	-	17	3317	c.3216C>G	c.(3214-3216)CTC>CTG	p.L1072L	C3orf63_uc003dib.3_Silent_p.L191L|C3orf63_uc003dic.3_Silent_p.L696L|C3orf63_uc003die.3_Silent_p.L1133L	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1133										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		GTGGCTCAAGGAGATGTTTAT	0.438			NA											11	124					0	0	0.000978	0	0
ZNF717	100131827	broad.mit.edu	37	3	75790798	75790798	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:75790798G>A	uc011bgi.1	-	3	470	c.147C>T	c.(145-147)GAC>GAT	p.D49D	ZNF717_uc003dpw.3_RNA	NM_001128223	NP_001121695	C9JSV9	C9JSV9_HUMAN	zinc finger protein 717	49					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						CCAGCATCACGTCCCTGTACA	0.502			NA											5	0					0	0	0.001168	0	0
ADCY5	111	broad.mit.edu	37	3	123005609	123005609	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:123005609G>A	uc003egh.1	-	20	3580	c.3580C>T	c.(3580-3582)CCT>TCT	p.P1194S	ADCY5_uc003egg.1_Missense_Mutation_p.P852S	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1194	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding	p.P1194T(1)		ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TCGTACTGAGGCTTTCGTGCC	0.622			NA									OREG0015741	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	41					0	0	0.001984	0	0
MCM2	4171	broad.mit.edu	37	3	127339966	127339966	+	Silent	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:127339966C>G	uc003ejp.2	+	15	2556	c.2499C>G	c.(2497-2499)CTC>CTG	p.L833L	MCM2_uc011bkm.1_Silent_p.L703L|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.L786L	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	833					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						AGCTGTTGCTCTTCATACTGA	0.542			NA											13	145					0	0	0.001368	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	Colon(199;1504 1750 3362 26421 31210 32040)	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	74					0	0	0.000978	0	0
ABLIM2	84448	broad.mit.edu	37	4	8082509	8082509	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:8082509C>T	uc003gko.2	-	5	618	c.475G>A	c.(475-477)GAA>AAA	p.E159K	ABLIM2_uc003gkj.3_Missense_Mutation_p.E159K|ABLIM2_uc003gkm.3_Missense_Mutation_p.E159K|ABLIM2_uc003gkp.2_Missense_Mutation_p.E159K|ABLIM2_uc003gkq.2_Missense_Mutation_p.E159K|ABLIM2_uc003gkr.2_Missense_Mutation_p.E159K|ABLIM2_uc003gks.3_Missense_Mutation_p.E159K|ABLIM2_uc011bwl.1_Missense_Mutation_p.E164K	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	159	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						TTCTTGATTTCTGTGCCGCAG	0.557			NA											6	33					0	0	0.00308	0	0
CC2D2A	57545	broad.mit.edu	37	4	15539654	15539654	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:15539654G>C	uc010idv.2	+	17	2142	c.1897G>C	c.(1897-1899)GAG>CAG	p.E633Q	CC2D2A_uc003gnx.2_Missense_Mutation_p.E584Q|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	633					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						GATAGAGCAGGAGGTGAGGGA	0.612			NA											3	12					0	0	0.004672	0	0
PROM1	8842	broad.mit.edu	37	4	16019964	16019964	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:16019964G>A	uc003goo.2	-	8	1196	c.984C>T	c.(982-984)AGC>AGT	p.S328S	PROM1_uc003gor.2_Silent_p.S328S|PROM1_uc003gos.2_Silent_p.S319S|PROM1_uc003got.2_Silent_p.S328S|PROM1_uc003gou.2_Silent_p.S319S|PROM1_uc003gop.2_Silent_p.S319S|PROM1_uc003goq.3_Silent_p.S319S|PROM1_uc010iec.1_Silent_p.S206S	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	328	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						GTTCAGGGTTGCTATTCAGCT	0.547			NA											7	36					0	0	0.004482	0	0
STIM2	57620	broad.mit.edu	37	4	27004688	27004688	+	Silent	SNP	T	T	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:27004688T>C	uc003gsh.3	+	7	1420	c.1204T>C	c.(1204-1206)TTG>CTG	p.L402L	STIM2_uc003gsg.3_Silent_p.L402L|STIM2_uc010iex.2_Silent_p.L402L|STIM2_uc010iey.2_Silent_p.L26L	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	315	Cytoplasmic (Potential).|Potential.				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TGAATGTGAATTGAGTAGACG	0.398			NA											7	59					0	0	0.001984	0	0
UBA6	55236	broad.mit.edu	37	4	68499189	68499189	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:68499189C>G	uc003hdg.3	-	23	2068	c.2016G>C	c.(2014-2016)AAG>AAC	p.K672N		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	672					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						CACTCTGTATCTTCTAGAATG	0.348			NA											10	80					0	0	0.006214	0	0
FRAS1	80144	broad.mit.edu	37	4	79373458	79373458	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:79373458G>C	uc003hlb.2	+	47	7153	c.6713G>C	c.(6712-6714)AGA>ACA	p.R2238T		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2237	CSPG 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TTGATCTACAGAATCACCAGA	0.458			NA											9	42					0	0	0.004482	0	0
METTL14	57721	broad.mit.edu	37	4	119631267	119631267	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:119631267G>C	uc003icf.2	+	11	1297	c.1181G>C	c.(1180-1182)AGA>ACA	p.R394T	METTL14_uc003icg.2_Missense_Mutation_p.R356T	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	394						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						GAAATTGAGAGACTTCGACCA	0.478			NA											8	70					0	0	0.00308	0	0
FGB	2244	broad.mit.edu	37	4	155491675	155491675	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:155491675G>A	uc003ioa.3	+	8	1388	c.1349G>A	c.(1348-1350)GGA>GAA	p.G450E	FGB_uc003iob.3_3'UTR|FGB_uc010ipv.2_Missense_Mutation_p.G388E|FGB_uc010ipw.2_3'UTR|FGB_uc003ioc.3_Missense_Mutation_p.G231E	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	450	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TACTGGGGTGGACAGTACACC	0.463	NSCLC(106;1133 1613 21870 46110 52656)		NA											7	87					0	0	0.001984	0	0
IRF2	3660	broad.mit.edu	37	4	185320141	185320141	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:185320141C>T	uc003iwf.3	-	7	822	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	208					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		TCGTCGCTCTCAGTGGTCACC	0.552			NA											6	68					0	0	0.00308	0	0
FAT1	2195	broad.mit.edu	37	4	187519168	187519168	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr4:187519168C>T	uc003izf.2	-	23	12403	c.12215G>A	c.(12214-12216)GGA>GAA	p.G4072E	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4072	Extracellular (Potential).|EGF-like 3.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AACAAAGCCTCCGTTGTCGAC	0.413	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			4	73					0	0	0.001168	0	0
C5orf42	65250	broad.mit.edu	37	5	37169148	37169148	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:37169148C>G	uc011cpa.1	-	34	7209	c.6978G>C	c.(6976-6978)TTG>TTC	p.L2326F	C5orf42_uc011coy.1_Missense_Mutation_p.L826F|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.L1401F|C5orf42_uc003jkr.1_Missense_Mutation_p.L359F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2326										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GTTGAGGTGTCAAATTTTCTT	0.383			NA											22	151					0	0	0.002299	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41019038	41019038	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:41019038G>C	uc003jmj.3	-	25	3014	c.2524C>G	c.(2524-2526)CTG>GTG	p.L842V	HEATR7B2_uc003jmi.3_Missense_Mutation_p.L397V	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	842							binding			ovary(6)|central_nervous_system(2)	8						AGATTTTCCAGAGGTGGAAGG	0.483			NA											5	42					0	0	0.000602	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54603853	54603853	+	Silent	SNP	A	A	G	rs145515923		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:54603853A>G	uc003jpy.3	+	1	278	c.12A>G	c.(10-12)GCA>GCG	p.A4A	SKIV2L2_uc011cqi.1_5'UTR|DHX29_uc003jpx.2_5'Flank|DHX29_uc010ivw.2_5'Flank	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	4					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGGCGGACGCATTCGGAGATG	0.577	Melanoma(2;92 134 23744 29976 33782)		NA											7	75					0	0	0.004482	0	0
BHMT	635	broad.mit.edu	37	5	78417047	78417047	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:78417047G>C	uc003kfu.3	+	5	589	c.484G>C	c.(484-486)GAA>CAA	p.E162Q	BHMT_uc011cti.1_Intron	NM_001713	NP_001704	Q93088	BHMT1_HUMAN	betaine-homocysteine methyltransferase	162	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CCAGTATTTTGAACACGTTGA	0.343			NA											5	66					0	0	0.001984	0	0
GPR98	84059	broad.mit.edu	37	5	90020705	90020705	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:90020705G>C	uc003kju.2	+	46	9901	c.9805G>C	c.(9805-9807)GGC>CGC	p.G3269R	GPR98_uc003kjt.2_Missense_Mutation_p.G975R|GPR98_uc003kjv.2_Missense_Mutation_p.G869R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3269	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATCAGCTTCTGGCTGGTGTTT	0.333			NA											15	173					0	0	0.006122	0	0
KCTD16	57528	broad.mit.edu	37	5	143853393	143853393	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:143853393C>T	uc003lnm.1	+	4	1632	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C	KCTD16_uc003lnn.1_Missense_Mutation_p.R335C	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	335						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TCCCGTGACACGCCAGACCAA	0.597			NA											17	58					0	0	0.00499	0	0
FBXO38	81545	broad.mit.edu	37	5	147819233	147819233	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:147819233G>A	uc003lpf.1	+	19	3168	c.3048G>A	c.(3046-3048)CAG>CAA	p.Q1016Q	FBXO38_uc003lpg.1_Silent_p.Q941Q|FBXO38_uc003lph.2_Silent_p.Q771Q	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	1016						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTGGAGCAGAAGCTATTTA	0.448			NA											9	102					0	0	0.008291	0	0
ABLIM3	22885	broad.mit.edu	37	5	148624548	148624548	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:148624548G>A	uc003lpy.2	+	16	1707	c.1456G>A	c.(1456-1458)GAG>AAG	p.E486K	ABLIM3_uc003lpz.1_Missense_Mutation_p.E486K|ABLIM3_uc003lqa.1_Missense_Mutation_p.E383K|ABLIM3_uc003lqb.2_Missense_Mutation_p.E375K|ABLIM3_uc003lqc.1_Missense_Mutation_p.E453K|ABLIM3_uc003lqd.1_Missense_Mutation_p.E391K|ABLIM3_uc003lqf.2_Missense_Mutation_p.E375K|ABLIM3_uc003lqe.1_Missense_Mutation_p.E375K	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	486					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGGAGTCTGAGTACTGGAC	0.542			NA											5	70					0	0	0.000602	0	0
CD74	972	broad.mit.edu	37	5	149782841	149782841	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:149782841G>A	uc003lsc.2	-	7	671	c.660C>T	c.(658-660)ATC>ATT	p.I220I	CD74_uc003lsb.2_Intron|CD74_uc003lse.2_Intron|CD74_uc003lsd.2_Intron|CD74_uc003lsf.1_Silent_p.I220I	NM_001025159	NP_001020330	P04233	HG2A_HUMAN	CD74 antigen isoform a	220	Thyroglobulin type-1.|Extracellular (Potential).				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGACAGCAGGGATGTGGCTGA	0.572			NA	T	ROS1	NSCLC								14	151					0	0	0.00245	0	0
G3BP1	10146	broad.mit.edu	37	5	151183593	151183593	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:151183593G>A	uc003lun.2	+	12	1513	c.1342G>A	c.(1342-1344)GGA>AGA	p.G448R	G3BP1_uc003lum.2_Missense_Mutation_p.G448R|G3BP1_uc011dcu.1_Missense_Mutation_p.G266R|G3BP1_uc010jhz.2_Missense_Mutation_p.G266R|G3BP1_uc003luq.2_Missense_Mutation_p.G116R	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	448	Gly-rich.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			CCCTCCCCGTGGAGGCATGGT	0.612			NA											11	107					0	0	0.008291	0	0
FABP6	2172	broad.mit.edu	37	5	159640748	159640748	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:159640748G>A	uc003lxx.1	+	3	203	c.57G>A	c.(55-57)CTG>CTA	p.L19L	FABP6_uc003lxz.1_Silent_p.L19L	NM_001130958	NP_001124430	P51161	FABP6_HUMAN	gastrotropin isoform 1	Error:Variant_position_missing_in_P51161_after_alignment					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCAGGTTCTGAGAGCTGTGT	0.328	Colon(29;562 677 12756 16385 20992)		NA											15	116					0	0	0.00499	0	0
MAT2B	27430	broad.mit.edu	37	5	162943529	162943529	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr5:162943529G>C	uc003lzk.2	+	5	640	c.532G>C	c.(532-534)GCT>CCT	p.A178P	MAT2B_uc003lzj.2_Missense_Mutation_p.A167P|MAT2B_uc003lzl.1_Missense_Mutation_p.A178P|MAT2B_uc003lzm.2_5'Flank	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	178					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TCTAGGAGCTGCTGTTTTGAG	0.348			NA											15	54					0	0	0.003163	0	0
RANBP9	10048	broad.mit.edu	37	6	13644815	13644815	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:13644815G>A	uc003nbb.2	-	6	1133	c.1074C>T	c.(1072-1074)ATC>ATT	p.I358I	RANBP9_uc003nba.2_Silent_p.I17I	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	358					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			CTCGATCTCCGATAGGAAATC	0.378			NA											14	142					0	0	0.004007	0	0
NRSN1	140767	broad.mit.edu	37	6	24134591	24134591	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:24134591G>A	uc010jpq.1	+	3	273	c.36G>A	c.(34-36)CAG>CAA	p.Q12Q		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	12					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						GGTCCAGGCAGGCACAGGCTG	0.532			NA											7	40					0	0	0.00308	0	0
ZNF391	346157	broad.mit.edu	37	6	27368615	27368615	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:27368615C>G	uc003njf.1	+	3	984	c.466C>G	c.(466-468)CAA>GAA	p.Q156E		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	156	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						TATTGAACATCAAAGAACTCA	0.403			NA											10	99					0	0	0.001855	0	0
CLIC1	1192	broad.mit.edu	37	6	31701437	31701437	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:31701437C>T	uc003nwr.2	-	4	552	c.288G>A	c.(286-288)CTG>CTA	p.L96L	CLIC1_uc003rje.2_Silent_p.L96L	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	96	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						TCAGAGCTGCCAGCTTGGGGT	0.512			NA											8	55					0	0	0.006214	0	0
CENPQ	55166	broad.mit.edu	37	6	49456172	49456172	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:49456172G>C	uc003ozh.1	+	7	674	c.585G>C	c.(583-585)GAG>GAC	p.E195D		NM_018132	NP_060602	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	195	Potential.				CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2	Lung NSC(77;0.0128)					AAGAAGAGGAGAGAGTAAAAC	0.308			NA											5	95					0	0	0.001168	0	0
AKAP12	9590	broad.mit.edu	37	6	151670162	151670162	+	Silent	SNP	T	T	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:151670162T>G	uc011eep.1	+	4	876	c.636T>G	c.(634-636)GCT>GCG	p.A212A	AKAP12_uc003qoe.2_Silent_p.A212A|AKAP12_uc003qof.2_Silent_p.A114A|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.A107A	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	212					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CAGCAGGGGCTGGCGACCACA	0.517	Melanoma(141;1616 1805 10049 24534 51979)		NA											7	73					0	0	0.006214	0	0
SYNE1	23345	broad.mit.edu	37	6	152560670	152560670	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr6:152560670C>G	uc010kiw.2	-	108	20667	c.20065G>C	c.(20065-20067)GAG>CAG	p.E6689Q	SYNE1_uc010kiv.2_Missense_Mutation_p.E1213Q|SYNE1_uc003qos.3_Missense_Mutation_p.E1213Q|SYNE1_uc003qot.3_Missense_Mutation_p.E6618Q|SYNE1_uc003qou.3_Missense_Mutation_p.E6689Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6689	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTCTCACCTCTAGAATGTAC	0.463			NA								HNSCC(10;0.0054)			8	64					0	0	0.008291	0	0
EIF3B	8662	broad.mit.edu	37	7	2409165	2409165	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:2409165G>C	uc003slx.2	+	10	1545	c.1462G>C	c.(1462-1464)GAT>CAT	p.D488H	EIF3B_uc003sly.2_Missense_Mutation_p.D488H|EIF3B_uc003sma.2_Missense_Mutation_p.D216H	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	488					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		TGAAGACAAAGATATTCCAGC	0.478			NA											16	226					0	0	0.004007	0	0
CCDC129	223075	broad.mit.edu	37	7	31683040	31683040	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:31683040C>T	uc003tcj.1	+	11	3049	c.2056C>T	c.(2056-2058)CAG>TAG	p.Q686*	CCDC129_uc011kad.1_Nonsense_Mutation_p.Q696*|CCDC129_uc003tci.1_Nonsense_Mutation_p.Q537*|CCDC129_uc011kae.1_Nonsense_Mutation_p.Q712*|CCDC129_uc003tck.1_Nonsense_Mutation_p.Q594*	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	686											0						TACTTTGGGTCAGATACTACC	0.512			NA											12	47					0	0	0.000978	0	0
DDC	1644	broad.mit.edu	37	7	50531022	50531022	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:50531022G>A	uc003tpf.3	-	14	1436	c.1350C>T	c.(1348-1350)ATC>ATT	p.I450I	DDC_uc010kza.2_Silent_p.I365I|DDC_uc003tpg.3_Silent_p.I450I	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	450					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TGCGAGAACAGATGGCAAAGC	0.522			NA											6	46					0	0	0.001168	0	0
HIP1	3092	broad.mit.edu	37	7	75178196	75178196	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:75178196C>T	uc003uds.1	-	23	2440	c.2399G>A	c.(2398-2400)AGA>AAA	p.R800K	HIP1_uc011kfz.1_Missense_Mutation_p.R677K	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	800	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TACCTCTATTCTGGCCGTGGC	0.547			NA	T	PDGFRB	CMML								20	198					0	0	0.001882	0	0
ZNF655	79027	broad.mit.edu	37	7	99170993	99170993	+	Missense_Mutation	SNP	C	C	T	rs141925358		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:99170993C>T	uc003urh.2	+	3	1655	c.1262C>T	c.(1261-1263)TCA>TTA	p.S421L	ZNF655_uc010lga.2_Missense_Mutation_p.S456L|ZNF655_uc010lgc.2_Missense_Mutation_p.S456L|ZNF655_uc003urj.2_Missense_Mutation_p.S421L|ZNF655_uc003urk.2_Missense_Mutation_p.S258L|ZNF655_uc010lgd.2_Missense_Mutation_p.S258L	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	421	C2H2-type 6.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AGTCAAACCTCATGCCTTATT	0.373			NA											10	64					0	0	0.006214	0	0
EPHB4	2050	broad.mit.edu	37	7	100420177	100420177	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:100420177T>C	uc003uwn.1	-	4	1015	c.524A>G	c.(523-525)TAC>TGC	p.Y175C	EPHB4_uc003uwm.1_Missense_Mutation_p.Y82C|EPHB4_uc010lhj.1_Missense_Mutation_p.Y175C|EPHB4_uc011kkf.1_Missense_Mutation_p.Y175C|EPHB4_uc011kkg.1_Missense_Mutation_p.Y175C|EPHB4_uc011kkh.1_Missense_Mutation_p.Y175C	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	175	Extracellular (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GAAGGCCAGGTAGAAGCCAGC	0.637	GBM(200;2113 3072 25865 52728)		NA											6	35					0	0	0.00308	0	0
PNPLA8	50640	broad.mit.edu	37	7	108119701	108119701	+	Silent	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:108119701C>G	uc003vff.1	-	11	2408	c.2001G>C	c.(1999-2001)GTG>GTC	p.V667V	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Silent_p.V667V|PNPLA8_uc003vfi.1_Silent_p.V567V|PNPLA8_uc003vfj.1_Silent_p.V667V|PNPLA8_uc003vfk.1_Silent_p.V567V	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	667					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						CCGTGTTTCTCACATCACTCT	0.408			NA											11	124					0	0	0.001368	0	0
BRAF	673	broad.mit.edu	37	7	140453155	140453155	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr7:140453155C>G	uc003vwc.3	-	15	1841	c.1780G>C	c.(1780-1782)GAT>CAT	p.D594H		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	594	Protein kinase.		D -> G (in NHL).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.D594G(27)|p.D594N(7)|p.D594K(3)|p.D594V(2)|p.D594_T599del(1)|p.D594E(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	AGACCAAAATCACCTATTTTT	0.378	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				7	67					0	0	0.004482	0	0
PSD3	23362	broad.mit.edu	37	8	18662370	18662370	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr8:18662370G>C	uc003wza.2	-	5	1776	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	PSD3_uc003wyy.2_Missense_Mutation_p.S24C|PSD3_uc003wyz.2_5'UTR	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	558	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CCCCATTTCAGAATGAGCTTC	0.393			NA											19	225					0	0	0.008871	0	0
VPS13B	157680	broad.mit.edu	37	8	100155244	100155244	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr8:100155244A>T	uc003yiv.2	+	13	1805	c.1694A>T	c.(1693-1695)GAT>GTT	p.D565V	VPS13B_uc003yiw.2_Missense_Mutation_p.D565V|VPS13B_uc003yit.2_Missense_Mutation_p.D565V|VPS13B_uc003yiu.1_Missense_Mutation_p.D565V|VPS13B_uc003yix.1_Missense_Mutation_p.D36V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	565					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAAAGTGAAGATTTGGGAACA	0.343	Colon(161;2205 2542 7338 31318)		NA											6	47					0	0	0.001984	0	0
WDR67	93594	broad.mit.edu	37	8	124109655	124109655	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr8:124109655G>C	uc003ypp.1	+	6	895	c.805G>C	c.(805-807)GAT>CAT	p.D269H	WDR67_uc011lig.1_Missense_Mutation_p.D269H|WDR67_uc011lih.1_Missense_Mutation_p.D159H|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.D269H|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	269						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTCTTCCTGATAGTTTTGA	0.398			NA											8	63					0	0	0.004482	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134475673	134475673	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr8:134475673C>G	uc003yuk.2	-	8	1542	c.713G>C	c.(712-714)AGA>ACA	p.R238T	ST3GAL1_uc003yum.2_Missense_Mutation_p.R238T	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	238	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			CTGTTTCACTCTGATCTTTGC	0.547			NA											6	86					0	0	0.001984	0	0
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.269			NA											6	268					0	0	0.001168	0	0
NAA35	60560	broad.mit.edu	37	9	88557126	88557126	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:88557126A>G	uc004aoi.3	+	2	189	c.52A>G	c.(52-54)ATG>GTG	p.M18V	NAA35_uc004aoj.3_Missense_Mutation_p.M18V|NAA35_uc004aok.1_Missense_Mutation_p.M18V	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	18					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						GGAGCTCAGTATGCCAGAAAA	0.388			NA											4	86					0	0	0.000248	0	0
GADD45G	10912	broad.mit.edu	37	9	92220654	92220654	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:92220654C>T	uc004aqq.2	+	3	338	c.228C>T	c.(226-228)ATC>ATT	p.I76I	GADD45G_uc004aqr.2_Silent_p.I58I	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	76					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						CGCTGCAGATCCATTTTACGC	0.647	Colon(131;320 2336 18973 23919)		NA											6	34					0	0	0.001168	0	0
GRIN3A	116443	broad.mit.edu	37	9	104390585	104390585	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:104390585C>G	uc004bbp.1	-	4	3052	c.2451G>C	c.(2449-2451)ATG>ATC	p.M817I	GRIN3A_uc004bbq.1_Missense_Mutation_p.M817I	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	817	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGTACCTTCTCATATATTCAT	0.428			NA											5	57					0	0	0.001984	0	0
OR2K2	26248	broad.mit.edu	37	9	114090198	114090198	+	Silent	SNP	G	G	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:114090198G>A	uc011lwp.1	-	1	516	c.516C>T	c.(514-516)CTC>CTT	p.L172L		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	201	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGTGATCGATGAGATTCCCAC	0.537			NA											5	59					0	0	0.001168	0	0
NUP188	23511	broad.mit.edu	37	9	131761475	131761475	+	Silent	SNP	C	C	A			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:131761475C>A	uc004bws.1	+	33	3562	c.3540C>A	c.(3538-3540)ATC>ATA	p.I1180I	NUP188_uc004bwu.2_Silent_p.I523I	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1180					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TGGATGAAATCCTTGGACCCT	0.368			NA									OREG0003925	type=REGULATORY REGION|Gene=AK025292|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	57					2.68362e-12	3.67383e-12	0.001368	1	0
NUP214	8021	broad.mit.edu	37	9	134006218	134006218	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:134006218C>T	uc004cag.2	+	5	769	c.658C>T	c.(658-660)CTT>TTT	p.L220F	NUP214_uc004cah.2_Missense_Mutation_p.L220F|NUP214_uc004caf.1_Missense_Mutation_p.L220F	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	220					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GGTCCAGTATCTTCCTGTAAG	0.403	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								7	55					0	0	0.001984	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070886	141070886	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:141070886A>G	uc004com.2	+	4	550	c.289A>G	c.(289-291)ATC>GTC	p.I97V	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						CACATTCAGCATCCTGCCCTC	0.577			NA											4	38					0	0	0.003163	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070915	141070915	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr9:141070915C>T	uc004com.2	+	4	579	c.318C>T	c.(316-318)ACC>ACT	p.T106T	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGTCAGACACCGTGGTGGAGC	0.522			NA											4	50					0	0	0.000978	0	0
IL3RA	3563	broad.mit.edu	37	X	1464320	1464320	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:1464320C>T	uc004cps.2	+	3	525	c.176C>T	c.(175-177)TCT>TTT	p.S59F	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	59	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCCGACTATTCTATGCCGGTA	0.284			NA											15	208					0	0	0.003163	0	0
EGFL6	25975	broad.mit.edu	37	X	13636018	13636018	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:13636018C>G	uc004cvi.2	+	8	1188	c.948C>G	c.(946-948)TTC>TTG	p.F316L	EGFL6_uc004cvj.2_Missense_Mutation_p.F316L|EGFL6_uc011mik.1_Missense_Mutation_p.F217L	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	316					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TGCAGCCCTTCAACTATGAAG	0.433			NA											7	99					0	0	0.004482	0	0
ZC4H2	55906	broad.mit.edu	37	X	64141841	64141841	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:64141841G>C	uc004dvu.2	-	2	169	c.81C>G	c.(79-81)ATC>ATG	p.I27M	ZC4H2_uc004dvv.2_Missense_Mutation_p.I4M|ZC4H2_uc011mov.1_Missense_Mutation_p.I4M|ZC4H2_uc011mow.1_Missense_Mutation_p.I27M|ZC4H2_uc004dvw.1_Missense_Mutation_p.I27M	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	27	Potential.						metal ion binding|protein binding			ovary(1)	1						AACGAGCCTTGATCTTCTCCA	0.468			NA											4	52					0	0	0.000248	0	0
FAM155B	27112	broad.mit.edu	37	X	68749637	68749637	+	Silent	SNP	G	G	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:68749637G>T	uc004dxk.2	+	3	1305	c.1257G>T	c.(1255-1257)CCG>CCT	p.P419P		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	420						integral to membrane				ovary(1)|breast(1)	2						CCCTGCTGCCGGTCTCTGGGG	0.463			NA											5	50					0.000602214	0.000794675	0.000602	1	0
AFF2	2334	broad.mit.edu	37	X	147743947	147743947	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:147743947C>T	uc004fcp.2	+	3	1178	c.699C>T	c.(697-699)ATC>ATT	p.I233I	AFF2_uc004fco.2_Silent_p.I229I|AFF2_uc004fcq.2_Silent_p.I229I|AFF2_uc004fcr.2_Silent_p.I229I|AFF2_uc011mxb.1_Silent_p.I233I|AFF2_uc004fcs.2_Silent_p.I229I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	233					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCAAAGAAATCTTTCAATCCA	0.473			NA											33	234					0	0	0.004289	0	0
Unknown	0	broad.mit.edu	37	X	155252691	155252691	+	Silent	SNP	C	C	T			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chrX:155252691C>T	uc004fnw.1	+	6	1394	c.735C>T	c.(733-735)TAC>TAT	p.Y245Y	uc004fnx.3_Silent_p.Y31Y	NM_182905	NP_878908			WAS protein family homolog 1												NA						CAGAGAACTACTTCTATGTGC	0.577			NA											5	11					0	0	0.001168	0	0
C11orf74	119710	broad.mit.edu	37	11	36669602	36669620	+	Frame_Shift_Del	DEL	TAAGCACCAGCATTCCTTC	TAAGCACCAGCATTCCTTC	-	rs148376199		TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	TAAGCACCAGCATTCCTTC	TAAGCACCAGCATTCCTTC	-	-	TAAGCACCAGCATTCCTTC	TAAGCACCAGCATTCCTTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr11:36669602_36669620delTAAGCACCAGCATTCCTTC	uc001mwy.1	+	5	468_486	c.395_413delTAAGCACCAGCATTCCTTC	c.(394-414)GTAAGCACCAGCATTCCTTCCfs	p.V132fs	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Frame_Shift_Del_p.V58fs|C11orf74_uc001mwx.1_RNA|C11orf74_uc001mwz.1_Frame_Shift_Del_p.V58fs|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	132_138											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				GAGCAGGATGTAAGCACCAGCATTCCTTCCTGTATCCCT	0.452			NA											9	133	---	---	---	---	NA	NA	NA	NA	NA
RAD51C	5889	broad.mit.edu	37	17	56774132	56774132	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr17:56774132delG	uc002iwu.2	+	3	525	c.483delG	c.(481-483)GAGfs	p.E161fs	RAD51C_uc010woa.1_Frame_Shift_Del_p.E161fs|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	161					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTGATACAGAGGGAAGTTTTA	0.423			NA						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				11	90	---	---	---	---	NA	NA	NA	NA	NA
ATP8B3	148229	broad.mit.edu	37	19	1805421	1805421	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr19:1805421delC	uc002ltw.2	-	10	1090	c.856delG	c.(856-858)GTCfs	p.V286fs	ATP8B3_uc002ltv.2_Frame_Shift_Del_p.V233fs|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Frame_Shift_Del_p.V34fs|ATP8B3_uc002ltz.1_Frame_Shift_Del_p.V233fs	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	286	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGTGGGTGACCATCAGGGCC	0.527			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MAPK12	6300	broad.mit.edu	37	22	50699715	50699715	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5044-01A-21D-1855-08	TCGA-50-5044-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ec034986-4bf7-4554-b635-ca6d9c30da28	27f19543-1a9f-4521-a46a-f4c470a4a5b0	g.chr22:50699715delC	uc003bkm.1	-	2	287	c.136delG	c.(136-138)GACfs	p.D46fs	MAPK12_uc003bkn.2_5'UTR|MAPK12_uc003bko.2_5'UTR|MAPK12_uc003bkl.1_Frame_Shift_Del_p.D46fs|MAPK12_uc003bkq.2_5'UTR|MAPK12_uc010haw.2_Frame_Shift_Del_p.D46fs	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	46	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGCGGCCGTCCACGGCCGAG	0.498			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
