Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DDI2	84301	broad.mit.edu	37	1	15956966	15956966	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:15956966C>T	uc001awx.1	+	3	511	c.415C>T	c.(415-417)CGA>TGA	p.R139*	DDI2_uc001aww.2_Nonsense_Mutation_p.R139*|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	139					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AGCCTTGCTCCGAGATATGTT	0.557			NA											4	54					0	0	0.009096	0	0
LAPTM5	7805	broad.mit.edu	37	1	31211800	31211800	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:31211800G>A	uc001bsc.2	-	5	588	c.497C>T	c.(496-498)TCC>TTC	p.S166F		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	166					transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGTTCATGGACTTGAAGTT	0.393			NA											4	9					0	0	0.009096	0	0
WDR65	149465	broad.mit.edu	37	1	43638521	43638521	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:43638521C>G	uc001cip.1	+	2	218	c.97C>G	c.(97-99)CCT>GCT	p.P33A	EBNA1BP2_uc001cio.2_5'UTR|WDR65_uc010ojz.1_5'UTR|WDR65_uc001ciq.1_Missense_Mutation_p.P33A|EBNA1BP2_uc001cim.2_5'Flank|EBNA1BP2_uc001cin.2_5'Flank|EBNA1BP2_uc010ojx.1_5'Flank|EBNA1BP2_uc010ojy.1_5'Flank	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	33										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CATTATATTTCCTTCAGGAAA	0.408			NA											8	47					0	0	0.00308	0	0
SYCP1	6847	broad.mit.edu	37	1	115455691	115455691	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:115455691C>G	uc001efr.2	+	19	1776	c.1567C>G	c.(1567-1569)CTT>GTT	p.L523V	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.L523V|SYCP1_uc009wgw.2_Missense_Mutation_p.L523V	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	523	Potential.			LTSHCNKLSLENK -> YFTLQQASPPPN (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCAACAAGCTTTCACTAGA	0.239			NA											28	72					0	0	0.009535	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874682	144874682	+	Silent	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:144874682T>C	uc001elw.3	-	30	5217	c.4926A>G	c.(4924-4926)TCA>TCG	p.S1642S	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.S1598S|PDE4DIP_uc001elv.3_Silent_p.S649S	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1642	NBPF.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGAGGCTACCTGAGTGACTGG	0.498			NA	T	PDGFRB	MPD								134	363					0	0	0.01441	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058113	152058113	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:152058113T>C	uc001ezo.1	-	3	2110	c.2045A>G	c.(2044-2046)GAC>GGC	p.D682G		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	682							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GGAAAGCTGGTCAGTGAAGTC	0.478			NA											118	229					0	0	0.01441	0	0
HRNR	388697	broad.mit.edu	37	1	152191409	152191409	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:152191409C>A	uc001ezt.1	-	3	2772	c.2696G>T	c.(2695-2697)GGG>GTG	p.G899V		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	899	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCCCTGACCCAGACCCACG	0.647			NA											42	208					7.05121e-23	1.43263e-22	0.010771	1	0
IGSF8	93185	broad.mit.edu	37	1	160063787	160063787	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:160063787A>C	uc001fva.2	-	3	662	c.617T>G	c.(616-618)GTG>GGG	p.V206G	IGSF8_uc001fuz.2_Missense_Mutation_p.V206G|IGSF8_uc009wtf.2_Missense_Mutation_p.V206G	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	206	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGCCTCGGGCACAGATCGCCC	0.627			NA											10	115					0	0	0.008291	0	0
TBX19	9095	broad.mit.edu	37	1	168262479	168262479	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:168262479C>T	uc001gfl.2	+	3	617	c.566C>T	c.(565-567)ACC>ATC	p.T189I	TBX19_uc001gfj.3_Missense_Mutation_p.T120I	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	189	T-box.				anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					TTCCCTGAAACCCAGTTCATA	0.363			NA											15	56					0	0	0.003163	0	0
FAM5B	57795	broad.mit.edu	37	1	177250606	177250606	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:177250606C>T	uc001glf.2	+	8	2606	c.2294C>T	c.(2293-2295)GCT>GTT	p.A765V	FAM5B_uc001glg.2_Missense_Mutation_p.A660V	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	765						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCCCTGAGGGCTTTCAATTCT	0.557			NA											14	125					0	0	0.004007	0	0
SYT14	255928	broad.mit.edu	37	1	210334260	210334260	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:210334260A>C	uc009xcv.2	+	8	1613	c.1541A>C	c.(1540-1542)AAA>ACA	p.K514T	SYT14_uc001hhs.3_Missense_Mutation_p.K578T|SYT14_uc001hht.3_Missense_Mutation_p.K533T|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.K559T|SYT14_uc010pso.1_Missense_Mutation_p.K476T|SYT14_uc010psp.1_Missense_Mutation_p.K52T	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	514	Cytoplasmic (Potential).|C2 2.			K -> E (in Ref. 1; BAC76809 and 3; BAC03682).		integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		ATGAAAAGAAAAGAGATGATA	0.393			NA											93	121					0	0	0.01441	0	0
BPNT1	10380	broad.mit.edu	37	1	220246208	220246208	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:220246208G>C	uc001hma.2	-	4	489	c.317C>G	c.(316-318)GCT>GGT	p.A106G	BPNT1_uc010pug.1_Missense_Mutation_p.A51G|BPNT1_uc010puh.1_Intron|BPNT1_uc001hmb.3_Missense_Mutation_p.A106G	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	106					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		TTCTTTAATAGCACTGTACTG	0.393			NA											14	172					0	0	0.004007	0	0
LEFTY1	10637	broad.mit.edu	37	1	226110038	226110038	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:226110038G>T	uc010pvj.1	-	3	339	c.184C>A	c.(184-186)CAC>AAC	p.H62N	PYCR2_uc001hpp.2_Missense_Mutation_p.H26N|PYCR2_uc001hpq.2_Missense_Mutation_p.H62N|PYCR2_uc001hpr.2_Missense_Mutation_p.H15N|PYCR2_uc001hps.1_Missense_Mutation_p.H15N			O75610	LFTY1_HUMAN	SubName: Full=cDNA FLJ54750, moderately similar to Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2);	Error:Variant_position_missing_in_O75610_after_alignment					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					ACGTCGCTGTGCTTCACCGTC	0.572			NA											67	57					4.29146e-36	9.63696e-36	0.01441	1	0
FMN2	56776	broad.mit.edu	37	1	240635749	240635749	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:240635749G>T	uc010pyd.1	+	17	5363	c.5138G>T	c.(5137-5139)GGA>GTA	p.G1713V	FMN2_uc010pye.1_Missense_Mutation_p.G1717V|FMN2_uc010pyg.1_Missense_Mutation_p.G309V|FMN2_uc001hyr.2_RNA	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1713					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CATGACTCTGGAATTGTAAGT	0.279			NA											27	109					4.72057e-08	8.16531e-08	0.003954	1	0
RGS7	6000	broad.mit.edu	37	1	240975303	240975303	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr1:240975303C>A	uc001hyv.2	-	14	1327	c.997G>T	c.(997-999)GGC>TGC	p.G333C	RGS7_uc010pyh.1_Missense_Mutation_p.G307C|RGS7_uc010pyj.1_Missense_Mutation_p.G249C|RGS7_uc001hyu.2_Missense_Mutation_p.G333C|RGS7_uc009xgn.1_Missense_Mutation_p.G280C|RGS7_uc001hyw.2_Missense_Mutation_p.G333C|RGS7_uc001hyt.2_Missense_Mutation_p.G165C	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	333	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCGTCCATGCCAAAACCCCAT	0.388			NA											30	153					3.73148e-12	6.82327e-12	0.007291	1	0
GAD2	2572	broad.mit.edu	37	10	26513487	26513488	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr10:26513487_26513488CC>AA	uc001isp.2	+	6	1134_1135	c.631_632CC>AA	c.(631-633)CCA>AAA	p.P211K	GAD2_uc001isq.2_Missense_Mutation_p.P211K	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	211					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGAAATTGCTCCAGTATTTGTG	0.381			NA											27	65					0	0	0.004672	0	0
BTRC	8945	broad.mit.edu	37	10	103310589	103310589	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr10:103310589C>T	uc001kta.2	+	14	1903	c.1790C>T	c.(1789-1791)TCT>TTT	p.S597F	BTRC_uc001ktb.2_Missense_Mutation_p.S561F|BTRC_uc001ktc.2_Missense_Mutation_p.S571F	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	597					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CGTTCCCCTTCTCGAACATAC	0.453			NA											38	71					0	0	0.005524	0	0
POLL	27343	broad.mit.edu	37	10	103345714	103345714	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr10:103345714C>T	uc001ktg.1	-	2	1081	c.315G>A	c.(313-315)CCG>CCA	p.P105P	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Silent_p.P105P|POLL_uc001ktj.1_Silent_p.P105P|POLL_uc001ktf.2_Silent_p.P105P|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Silent_p.P105P|POLL_uc001ktl.2_Silent_p.P17P|POLL_uc010qqc.1_5'UTR|POLL_uc010qqd.1_Silent_p.P17P|DPCD_uc001ktn.2_5'Flank	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	105	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GCTGAGCACCCGGGGGCAGCT	0.602			NA						DNA_polymerases_(catalytic_subunits)					8	44					0	0	0.00308	0	0
GFRA1	2674	broad.mit.edu	37	10	117885010	117885010	+	Silent	SNP	G	G	A	rs79176106		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr10:117885010G>A	uc001lcj.2	-	6	1190	c.492C>T	c.(490-492)GAC>GAT	p.D164D	GFRA1_uc001lci.2_Silent_p.D159D|GFRA1_uc009xyr.2_Silent_p.D159D	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	164	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGCAAATGTCGTCGAGGTTGC	0.587	Ovarian(128;329 1725 45498 46808 50759)		NA											9	40					0	0	0.006214	0	0
NUP98	4928	broad.mit.edu	37	11	3797197	3797197	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:3797197G>C	uc001lyh.2	-	5	701	c.410C>G	c.(409-411)TCT>TGT	p.S137C	NUP98_uc001lyi.2_Missense_Mutation_p.S137C|NUP98_uc001lyj.1_Missense_Mutation_p.S137C|NUP98_uc001lyk.1_Missense_Mutation_p.S137C|NUP98_uc010qxv.1_Missense_Mutation_p.S100C	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	137	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AAAAGGATTAGAGGTGGTATT	0.378			NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								93	134					0	0	0.01441	0	0
CCDC73	493860	broad.mit.edu	37	11	32676433	32676433	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:32676433A>T	uc001mtv.2	-	10	775	c.731T>A	c.(730-732)ATT>AAT	p.I244N	CCDC73_uc001mtw.1_Missense_Mutation_p.I244N	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	244	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTGTTCTTTAATTGTTAGATT	0.259			NA											5	23					0	0	0.000602	0	0
BBS1	582	broad.mit.edu	37	11	66297387	66297387	+	Silent	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:66297387C>A	uc001oij.1	+	14	1449	c.1437C>A	c.(1435-1437)TCC>TCA	p.S479S	BBS1_uc001oii.1_Silent_p.S516S|BBS1_uc010rpg.1_Silent_p.S382S|BBS1_uc001oik.1_Silent_p.S403S|BBS1_uc001oil.1_Silent_p.S350S|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Silent_p.S147S	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	479					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						GCCCCCTGTCCACGACAGCCC	0.677	GBM(152;173 2612 9770 10137)		NA							Bardet-Biedl_syndrome				6	19					0.00198382	0.00305938	0.001984	1	0
TECTA	7007	broad.mit.edu	37	11	121000732	121000732	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:121000732C>T	uc010rzo.1	+	9	2753	c.2753C>T	c.(2752-2754)CCC>CTC	p.P918L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	918	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ATCAACGACCCCTCCAACAGC	0.577			NA											30	50					0	0	0.008361	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126276877	126276877	+	Silent	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:126276877C>G	uc001qds.2	+	4	360	c.141C>G	c.(139-141)CTC>CTG	p.L47L	ST3GAL4_uc001qdt.2_Silent_p.L43L|ST3GAL4_uc009zcc.2_5'UTR|ST3GAL4_uc009zcd.2_Silent_p.L36L|ST3GAL4_uc001qdu.2_Silent_p.L43L|ST3GAL4_uc001qdv.2_Silent_p.L47L|ST3GAL4_uc009zce.2_Silent_p.L43L|ST3GAL4_uc001qdw.2_Silent_p.L36L|ST3GAL4_uc001qdx.1_Silent_p.L36L|ST3GAL4_uc001qdy.2_5'UTR|ST3GAL4_uc001qdz.2_5'Flank	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	47	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		AGCCGTGCCTCCAGGGTGAGG	0.542			NA											21	88					0	0	0.00333	0	0
ANO2	57101	broad.mit.edu	37	12	5848490	5848490	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:5848490T>C	uc001qnm.2	-	13	1487	c.1415A>G	c.(1414-1416)GAG>GGG	p.E472G		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	477	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CACTTCTTCCTCTTCTATGCC	0.428			NA											9	4					0	0	0.004482	0	0
A2ML1	144568	broad.mit.edu	37	12	8998736	8998736	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:8998736T>A	uc001quz.3	+	14	1699	c.1601T>A	c.(1600-1602)CTG>CAG	p.L534Q	A2ML1_uc001qva.1_Missense_Mutation_p.L114Q|A2ML1_uc010sgm.1_Missense_Mutation_p.L34Q	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	378						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GATCCTTCCCTGGTGATCTAT	0.453			NA											58	51					0	0	0.01441	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			13	7					2.68362e-12	4.97831e-12	0.013537	1	0
KRT7	3855	broad.mit.edu	37	12	52627365	52627365	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:52627365C>G	uc001saa.1	+	1	412	c.285C>G	c.(283-285)ATC>ATG	p.I95M	KRT7_uc009zmf.1_Missense_Mutation_p.I95M	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	95	Rod.|Interaction with HPV16 E7.|Coil 1A.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GCGAGCAGATCAAGACCCTCA	0.657			NA											46	65					0	0	0.01441	0	0
RAB5B	5869	broad.mit.edu	37	12	56380777	56380777	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:56380777G>T	uc001siv.2	+	2	150	c.33G>T	c.(31-33)GGG>GGT	p.G11G	RAB5B_uc001siw.2_Silent_p.G11G|RAB5B_uc009zog.2_Missense_Mutation_p.G2V|RAB5B_uc010spz.1_Silent_p.G11G	NM_002868	NP_002859	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	11					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			GGCCCAATGGGCAACCCCAGG	0.368			NA											21	44					1.50039e-11	2.70493e-11	0.012319	1	0
RAP1B	5908	broad.mit.edu	37	12	69047944	69047944	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:69047944C>T	uc001sub.2	+	5	399	c.236C>T	c.(235-237)GCA>GTA	p.A79V	RAP1B_uc010ste.1_Missense_Mutation_p.A13V|RAP1B_uc001suc.2_Missense_Mutation_p.A79V|RAP1B_uc010stf.1_Missense_Mutation_p.A60V|RAP1B_uc010stg.1_Missense_Mutation_p.A37V|RAP1B_uc010sth.1_Missense_Mutation_p.A37V|RAP1B_uc010sti.1_Intron	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	79					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		CAAGGATTTGCATTAGTTTAT	0.343			NA											9	363					0	0	0.008291	0	0
PAWR	5074	broad.mit.edu	37	12	80014945	80014945	+	Missense_Mutation	SNP	G	G	A	rs147882965		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:80014945G>A	uc001syx.2	-	3	845	c.559C>T	c.(559-561)CGG>TGG	p.R187W		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	187	Selective for apoptosis induction in cancer cells (SAC).|Potential.				actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						TCTCGTTTCCGCTCTTTCTGC	0.363			NA											30	228					0	0	0.013726	0	0
CLIP1	6249	broad.mit.edu	37	12	122862287	122862287	+	Silent	SNP	C	C	A	rs115820623	byFrequency	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:122862287C>A	uc001ucg.1	-	2	412	c.306G>T	c.(304-306)TCG>TCT	p.S102S	CLIP1_uc001uch.1_Silent_p.S102S|CLIP1_uc001uci.1_Silent_p.S102S|CLIP1_uc010tae.1_Silent_p.S102S	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	102	CAP-Gly 1.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTCCTGCCACCGAACCATCGT	0.453			NA											59	180					1.53716e-24	3.17348e-24	0.01441	1	0
EP400	57634	broad.mit.edu	37	12	132504687	132504687	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr12:132504687G>T	uc001ujn.2	+	21	4406	c.4371G>T	c.(4369-4371)ACG>ACT	p.T1457T	EP400_uc001ujl.2_Silent_p.T1456T|EP400_uc001ujm.2_Silent_p.T1457T	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1493					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCCCACCACGGCCTCTGCTG	0.642			NA											49	78					1.35964e-18	2.67744e-18	0.01441	1	0
FLT3	2322	broad.mit.edu	37	13	28602366	28602366	+	Silent	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr13:28602366G>A	uc001urw.2	-	16	2084	c.2002C>T	c.(2002-2004)CTG>TTG	p.L668L	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.L668L	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	668	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCTTCCCAGCTGGGTCATC	0.443			NA	Mis|O		AML|ALL								43	21					0	0	0.013114	0	0
MYO16	23026	broad.mit.edu	37	13	109777613	109777613	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr13:109777613C>T	uc001vqt.1	+	30	3749	c.3623C>T	c.(3622-3624)GCC>GTC	p.A1208V	MYO16_uc010agk.1_Missense_Mutation_p.A1230V|MYO16_uc010tjh.1_Missense_Mutation_p.A720V	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1208					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCAGACATTGCCCGGGAAAAT	0.473			NA											3	24					0	0	0.004672	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215612	20215612	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr14:20215612T>A	uc010tkt.1	+	1	26	c.26T>A	c.(25-27)GTG>GAG	p.V9E		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GATTCTAATGTGACAGAATTT	0.338			NA											57	210					0	0	0.01441	0	0
OR4M1	441670	broad.mit.edu	37	14	20248599	20248600	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr14:20248599_20248600CC>AA	uc010tku.1	+	1	118_119	c.118_119CC>AA	c.(118-120)CCA>AAA	p.P40K		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTTCATCCTACCAGGAAATATC	0.431			NA											126	667					0	0	0.004672	0	0
PCK2	5106	broad.mit.edu	37	14	24566321	24566321	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr14:24566321C>T	uc001wlt.2	+	2	382	c.250C>T	c.(250-252)CGA>TGA	p.R84*	NRL_uc001wlp.2_5'Flank|NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Nonsense_Mutation_p.R96*|PCK2_uc001wls.2_Nonsense_Mutation_p.R84*|PCK2_uc010tnw.1_Intron|PCK2_uc010ald.2_5'UTR|PCK2_uc010ale.2_5'UTR|PCK2_uc010tnx.1_5'UTR|PCK2_uc001wlu.3_5'UTR	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	84					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		GGGCCTCATCCGAAAGCTCCC	0.552			NA											5	101					0	0	0.001168	0	0
TBPL2	387332	broad.mit.edu	37	14	55903438	55903438	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr14:55903438C>A	uc001xby.2	-	2	449	c.449G>T	c.(448-450)AGT>ATT	p.S150I		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	150					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						ATTTGACAAACTGCTGCTGTT	0.493			NA											25	88					2.21704e-12	4.14278e-12	0.00278	1	0
TGM5	9333	broad.mit.edu	37	15	43552356	43552356	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr15:43552356C>T	uc001zrd.1	-	3	338	c.330G>A	c.(328-330)GCG>GCA	p.A110A	TGM5_uc001zre.1_Intron	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	110					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GACCCACGGCCGCCGTGGGAG	0.617			NA											19	61					0	0	0.012319	0	0
CKMT1B	1159	broad.mit.edu	37	15	43890472	43890472	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr15:43890472C>G	uc001zsc.2	+	8	1350	c.958C>G	c.(958-960)CTG>GTG	p.L320V	CKMT1B_uc010uds.1_Missense_Mutation_p.L351V|CKMT1B_uc010udv.1_3'UTR|CKMT1B_uc001zsd.3_Missense_Mutation_p.L320V|CKMT1B_uc010bdj.2_RNA|CKMT1B_uc010udy.1_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	320	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	TCCATCTAACCTGGGCACTGG	0.512			NA											4	114					0	0	0.001168	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	Silent	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr15:78211548T>C	uc010bky.2	-	11	983	c.219A>G	c.(217-219)CAA>CAG	p.Q73Q		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CCACCTGGGATTGGAGCTTTC	0.562			NA											5	213					0	0	0.001168	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250433	1250433	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:1250433C>T	uc002cks.2	+	7	1229	c.981C>T	c.(979-981)GCC>GCT	p.A327A	CACNA1H_uc002ckt.2_Silent_p.A327A	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	327	Extracellular (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCCGCAGGCCGAGGGGGTGG	0.672			NA											8	24					0	0	0.004482	0	0
XYLT1	64131	broad.mit.edu	37	16	17202764	17202764	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:17202764G>T	uc002dfa.2	-	12	2753	c.2668C>A	c.(2668-2670)CAG>AAG	p.Q890K		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	890	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CTCCGTGCCTGTTCCACCTGG	0.647			NA											37	47					6.86731e-36	1.52872e-35	0.006999	1	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	G	A	rs150520281	by1000genomes	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254			NA											3	30					0	0	0.004672	0	0
USP31	57478	broad.mit.edu	37	16	23160107	23160107	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:23160107C>A	uc002dll.2	-	1	485	c.485G>T	c.(484-486)CGG>CTG	p.R162L		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	162					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CCGCCCCGCCCGGTACTGGCC	0.731			NA											4	15					0.000602214	0.000940042	0.000602	1	0
NAE1	8883	broad.mit.edu	37	16	66842900	66842900	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:66842900T>A	uc002eqf.2	-	16	1306	c.1229A>T	c.(1228-1230)GAT>GTT	p.D410V	NAE1_uc002eqe.2_Missense_Mutation_p.D404V|NAE1_uc002eqg.2_Missense_Mutation_p.D321V|NAE1_uc010cdv.2_Missense_Mutation_p.D413V	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	410					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	ACTAATTTCATCCTTGTTAAT	0.299			NA											10	39					0	0	0.010729	0	0
DUS2L	54920	broad.mit.edu	37	16	68104848	68104848	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:68104848G>T	uc002evi.2	+	12	796	c.647G>T	c.(646-648)GGA>GTA	p.G216V	DUS2L_uc002evj.2_Missense_Mutation_p.G216V|DUS2L_uc010vkk.1_Missense_Mutation_p.G181V|DUS2L_uc010cez.2_Missense_Mutation_p.G129V	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	216					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TTTAGCGGAGGATCTCATGAC	0.463			NA											4	65					0.00024832	0.00039	0.009096	1	0
PDPR	55066	broad.mit.edu	37	16	70164389	70164389	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:70164389G>C	uc002eyf.1	+	7	1628	c.671G>C	c.(670-672)GGA>GCA	p.G224A	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.G124A|PDPR_uc002eyg.1_5'Flank	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	224					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		CAAGTTACTGGAGTGGAGACC	0.428			NA											15	72					0	0	0.00245	0	0
CALB2	794	broad.mit.edu	37	16	71406079	71406079	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:71406079G>C	uc002faa.3	+	2	188	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Missense_Mutation_p.E40Q	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	40	1 (Probable).|EF-hand 1.						calcium ion binding				0		Ovarian(137;0.125)				TGAAGGTAAAGAGCTAGAAAA	0.478			NA											25	123					0	0	0.003954	0	0
ZFHX3	463	broad.mit.edu	37	16	72830437	72830437	+	Silent	SNP	T	T	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:72830437T>G	uc002fck.2	-	9	6817	c.6144A>C	c.(6142-6144)CCA>CCC	p.P2048P	ZFHX3_uc002fcl.2_Silent_p.P1134P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2048	Poly-Pro.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GAAGTGGGGGTGGAGGGGGTG	0.642			NA											10	86					0	0	0.00278	0	0
ZMYND15	84225	broad.mit.edu	37	17	4648623	4648623	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:4648623C>T	uc002fyt.2	+	12	1932	c.1893C>T	c.(1891-1893)CCC>CCT	p.P631P	ZMYND15_uc002fyv.2_Silent_p.P670P|ZMYND15_uc002fyu.2_Silent_p.P678P	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	631							zinc ion binding				0						AGCCCAACCCCTTCCGCTCCC	0.612			NA											25	62					0	0	0.005443	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318895	21318895	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:21318895C>G	uc002gyv.1	+	3	946	c.241C>G	c.(241-243)CGG>GGG	p.R81G		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	81	Helical; Name=M1; (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CATCCGCTGGCGGTACATGCT	0.577			NA								Prostate(3;0.18)			6	44					0	0	0.00308	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319622	21319622	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:21319622G>T	uc002gyv.1	+	3	1673	c.968G>T	c.(967-969)TGG>TTG	p.W323L		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	323	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GAGATCCTGTGGGGTCACCGC	0.587			NA								Prostate(3;0.18)			15	196					1.49906e-05	2.41358e-05	0.00245	1	0
KRT23	25984	broad.mit.edu	37	17	39092709	39092709	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:39092709C>T	uc002hvm.1	-	2	736	c.147G>A	c.(145-147)ACG>ACA	p.T49T	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Silent_p.T49T|KRT23_uc002hvn.1_Silent_p.T49T	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	49	Head.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				GGCAGCTCCGCGTGGTGAAGG	0.687			NA											24	73					0	0	0.00333	0	0
CHAD	1101	broad.mit.edu	37	17	48545931	48545931	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:48545931G>T	uc010dbr.2	-	1	297	c.244C>A	c.(244-246)CTG>ATG	p.L82M	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.L82M|ACSF2_uc010dbt.1_Intron	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	82	LRR 1.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CAGTGCTGCAGGTGCAATGAC	0.602			NA											18	55					1.45105e-14	2.77216e-14	0.006122	1	0
C17orf56	146705	broad.mit.edu	37	17	79202754	79202754	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr17:79202754A>G	uc002jzu.1	-	12	1574	c.1552T>C	c.(1552-1554)TCA>CCA	p.S518P	C17orf56_uc002jzr.1_Missense_Mutation_p.S188P|C17orf56_uc002jzs.1_Missense_Mutation_p.S434P|C17orf56_uc002jzt.1_Missense_Mutation_p.S434P|C17orf56_uc002jzv.1_Missense_Mutation_p.S366P|uc002jzw.1_RNA	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	518						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCGAAAGCTGACGGCTCTGAG	0.647			NA											9	33					0	0	0.006214	0	0
PTPRM	5797	broad.mit.edu	37	18	8376062	8376062	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr18:8376062C>G	uc002knn.3	+	23	3654	c.3151C>G	c.(3151-3153)CGA>GGA	p.R1051G	PTPRM_uc010dkv.2_Missense_Mutation_p.R1064G|PTPRM_uc010wzl.1_Missense_Mutation_p.R838G	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1051	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCATGAAATCCGAGAGATCAG	0.532			NA											66	101					0	0	0.01441	0	0
KLHL14	57565	broad.mit.edu	37	18	30349722	30349722	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr18:30349722A>T	uc002kxm.1	-	2	1221	c.833T>A	c.(832-834)GTC>GAC	p.V278D		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	278	BACK.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						CACTGACTGGACCCGCTCCAC	0.647			NA											43	45					0	0	0.01441	0	0
ALPK2	115701	broad.mit.edu	37	18	56203629	56203629	+	Missense_Mutation	SNP	C	C	A	rs144733035	byFrequency	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr18:56203629C>A	uc002lhj.3	-	5	4004	c.3790G>T	c.(3790-3792)GGT>TGT	p.G1264C	ALPK2_uc002lhk.1_Missense_Mutation_p.G595C	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1264							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						ATGAGACCACCGTCTGATGCC	0.498			NA											48	123					4.00472e-15	7.70833e-15	0.01441	1	0
ELAVL1	1994	broad.mit.edu	37	19	8028583	8028583	+	Silent	SNP	G	G	A	rs141885519	byFrequency	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr19:8028583G>A	uc002mjb.2	-	6	932	c.765C>T	c.(763-765)GCC>GCT	p.A255A		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	255	RRM 3.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						TCCCCTCGTCGGCATCCTGCC	0.577			NA											4	79					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9068783	9068783	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr19:9068783G>T	uc002mkp.2	-	3	18867	c.18663C>A	c.(18661-18663)CTC>CTA	p.L6221L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6223	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGAGAAGAGAGAGAGTTGG	0.453			NA											49	47					8.48111e-28	1.79435e-27	0.01441	1	0
KEAP1	9817	broad.mit.edu	37	19	10602329	10602329	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr19:10602329C>T	uc002moq.1	-	3	1405	c.1249G>A	c.(1249-1251)GGG>AGG	p.G417R	KEAP1_uc002mop.1_Missense_Mutation_p.G135R|KEAP1_uc002mor.1_Missense_Mutation_p.G417R	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	417	Kelch 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACCCCCACCCCGATGCGGTTA	0.667			NA											7	6					0	0	0.001984	0	0
ZNF653	115950	broad.mit.edu	37	19	11598552	11598552	+	Silent	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr19:11598552C>A	uc002mrz.1	-	4	779	c.726G>T	c.(724-726)GTG>GTT	p.V242V		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGGAATGTGCACGCCCTCCT	0.682	Pancreas(83;980 1446 4542 6441 43352)		NA											16	42					6.94344e-10	1.21748e-09	0.006122	1	0
TTC32	130502	broad.mit.edu	37	2	20096878	20096878	+	Missense_Mutation	SNP	T	T	A	rs149286415		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:20096878T>A	uc002rdg.2	-	3	458	c.326A>T	c.(325-327)GAT>GTT	p.D109V		NM_001008237	NP_001008238	Q5I0X7	TTC32_HUMAN	tetratricopeptide repeat domain 32	109	TPR 3.						identical protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAAGCATCATCAAAATATCC	0.318			NA											18	45					0	0	0.007413	0	0
APLF	200558	broad.mit.edu	37	2	68772346	68772346	+	Silent	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:68772346T>C	uc002sep.2	+	8	1361	c.1188T>C	c.(1186-1188)TTT>TTC	p.F396F	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Silent_p.F372F|APLF_uc002ser.1_Silent_p.F127F	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	396	PBZ-type 1.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						TTCAACATTTTAGCCATCCTG	0.403			NA											28	82					0	0	0.00632	0	0
MOGS	7841	broad.mit.edu	37	2	74690042	74690042	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:74690042C>G	uc010ffj.2	-	4	1037	c.874G>C	c.(874-876)GCC>CCC	p.A292P	MOGS_uc010ffh.2_Missense_Mutation_p.A17P|MOGS_uc010yrt.1_Missense_Mutation_p.A173P|MOGS_uc010ffi.2_Missense_Mutation_p.A186P|MOGS_uc010yru.1_3'UTR	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	292	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						TCAGGGGGGGCCCCTGGGGGC	0.587			NA											5	232					0	0	0.000602	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459840	107459840	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:107459840G>T	uc002tdq.2	-	2	713	c.594C>A	c.(592-594)TCC>TCA	p.S198S	ST6GAL2_uc002tdr.2_Silent_p.S198S|ST6GAL2_uc002tds.3_Silent_p.S198S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	198	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CCCTGGACATGGAGGAGTACA	0.617			NA											22	70					2.89027e-11	5.13825e-11	0.014323	1	0
LRP1B	53353	broad.mit.edu	37	2	141707940	141707940	+	Silent	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:141707940C>A	uc002tvj.1	-	20	3972	c.3000G>T	c.(2998-3000)GTG>GTT	p.V1000V	LRP1B_uc010fnl.1_Silent_p.V182V	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1000	Extracellular (Potential).|LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAACACAGCCCACCTCATCAC	0.463	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			11	49					6.40141e-05	0.000102423	0.010729	1	0
CCDC150	284992	broad.mit.edu	37	2	197565880	197565880	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:197565880G>T	uc002utp.1	+	15	1806	c.1671G>T	c.(1669-1671)CTG>CTT	p.L557L	CCDC150_uc010zgs.1_Silent_p.L225L|CCDC150_uc010zgt.1_Silent_p.L31L	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	557	Potential.										0						AAAATAAACTGGCCTATGAAA	0.318			NA											11	22					1.08611e-07	1.86606e-07	0.010729	1	0
HDAC4	9759	broad.mit.edu	37	2	240098157	240098157	+	Missense_Mutation	SNP	G	G	C	rs140596122		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:240098157G>C	uc002vyk.3	-	5	1234	c.442C>G	c.(442-444)CGG>GGG	p.R148G	HDAC4_uc010fyz.1_Missense_Mutation_p.R143G|HDAC4_uc010zoa.1_Missense_Mutation_p.R143G|HDAC4_uc010fza.2_Missense_Mutation_p.R148G|HDAC4_uc010fyy.2_Missense_Mutation_p.R100G|HDAC4_uc010znz.1_Missense_Mutation_p.R31G	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	148	Interaction with MEF2A.|Potential.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ttctgctcccggtgctgcttc	0.154			NA											6	236					0	0	0.00308	0	0
SEL1L2	80343	broad.mit.edu	37	20	13830946	13830946	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr20:13830946C>T	uc010gcf.2	-	19	1920	c.1838G>A	c.(1837-1839)AGA>AAA	p.R613K	SEL1L2_uc002woq.3_Missense_Mutation_p.R474K|SEL1L2_uc010zrl.1_Missense_Mutation_p.R500K|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	613	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						GTCGTACAATCTTCTGGCCAA	0.448			NA											16	49					0	0	0.00499	0	0
ZMYND8	23613	broad.mit.edu	37	20	45920590	45920590	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr20:45920590C>A	uc002xta.1	-	6	804	c.550G>T	c.(550-552)GAC>TAC	p.D184Y	ZMYND8_uc010ghr.1_Missense_Mutation_p.D159Y|ZMYND8_uc002xst.1_Missense_Mutation_p.D159Y|ZMYND8_uc002xsu.1_Missense_Mutation_p.D184Y|ZMYND8_uc002xsv.1_Missense_Mutation_p.D159Y|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.D159Y|ZMYND8_uc002xsz.1_Missense_Mutation_p.D121Y|ZMYND8_uc010zxy.1_Missense_Mutation_p.D211Y|ZMYND8_uc002xtb.1_Missense_Mutation_p.D204Y|ZMYND8_uc002xss.2_Missense_Mutation_p.D184Y|ZMYND8_uc010zxz.1_Missense_Mutation_p.D179Y|ZMYND8_uc002xtc.1_Missense_Mutation_p.D204Y|ZMYND8_uc002xtd.1_Missense_Mutation_p.D179Y|ZMYND8_uc002xte.1_Missense_Mutation_p.D184Y|ZMYND8_uc010zya.1_Missense_Mutation_p.D184Y|ZMYND8_uc002xtf.1_Missense_Mutation_p.D204Y|ZMYND8_uc002xtg.2_Missense_Mutation_p.D178Y|ZMYND8_uc010ghs.1_Missense_Mutation_p.D178Y	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	184	Bromo.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCCGCATAGTCAGGGTGCTGT	0.458			NA											38	29					6.2361e-21	1.23755e-20	0.007835	1	0
APP	351	broad.mit.edu	37	21	27284177	27284177	+	Silent	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr21:27284177T>A	uc002ylz.2	-	14	1985	c.1785A>T	c.(1783-1785)CCA>CCT	p.P595P	APP_uc011acg.1_Silent_p.P103P|APP_uc010glk.2_Silent_p.P571P|APP_uc002yma.2_Silent_p.P576P|APP_uc011ach.1_Silent_p.P539P|APP_uc002ymb.2_Silent_p.P520P|APP_uc010glj.2_Silent_p.P464P|APP_uc011aci.1_Silent_p.P485P	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	595	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CGGTCAAAGATGGCATGAGAG	0.493			NA											4	43					0	0	0.001168	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210756	28210756	+	Splice_Site	SNP	A	A	G	rs113268450		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr21:28210756A>G	uc002ymf.2	-	8	2659	c.2204_splice	c.e8+1	p.K735_splice		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1						integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		TTTAAAACTTACTTTGCACTA	0.328			NA											41	21					0	0	0.007835	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843165	22843165	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr22:22843165T>C	uc002zwc.1	-	4	1335	c.559A>G	c.(559-561)AGG>GGG	p.R187G	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGTTTAGCCCTTTTGGGATTT	0.388			NA											3	140					0	0	0.004672	0	0
GRM7	2917	broad.mit.edu	37	3	7620336	7620336	+	Silent	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:7620336C>A	uc003bqm.2	+	8	2017	c.1743C>A	c.(1741-1743)ATC>ATA	p.I581I	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.I581I|GRM7_uc003bql.2_Silent_p.I581I|GRM7_uc003bqn.1_Silent_p.I164I|GRM7_uc010hch.1_Silent_p.I92I	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	581	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	ATATTCCCATCATCAAACTGG	0.517			NA											85	92					7.14593e-30	1.52446e-29	0.01441	1	0
LRTM1	57408	broad.mit.edu	37	3	54952687	54952687	+	Silent	SNP	C	C	A	rs150198745		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:54952687C>A	uc003dhl.2	-	3	971	c.837G>T	c.(835-837)CCG>CCT	p.P279P	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	279	Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GCAGGTTGGCCGGCCTTGGCT	0.602			NA											27	48					1.42536e-11	2.58788e-11	0.004656	1	0
C3orf63	23272	broad.mit.edu	37	3	56695042	56695042	+	Silent	SNP	A	A	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:56695042A>G	uc003did.3	-	10	1265	c.1164T>C	c.(1162-1164)CCT>CCC	p.P388P	C3orf63_uc003dic.3_5'UTR|C3orf63_uc003die.3_Silent_p.P388P	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	388										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		CTAATTTCTCAGGTCTGAAAG	0.313			NA											3	64					0	0	0.009096	0	0
IFT57	55081	broad.mit.edu	37	3	107885748	107885748	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:107885748C>G	uc003dwx.3	-	8	1182	c.934G>C	c.(934-936)GAG>CAG	p.E312Q		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	312	Potential.				activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			ACCAAATTCTCAAGCTGATTG	0.378			NA											9	47					0	0	0.004482	0	0
ADCY5	111	broad.mit.edu	37	3	123016213	123016213	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:123016213C>T	uc003egh.1	-	16	2917	c.2917G>A	c.(2917-2919)GGG>AGG	p.G973R	ADCY5_uc003egg.1_Missense_Mutation_p.G606R	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	973					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGGGAGGTCCCGTTGTTGAAG	0.637			NA											50	167					0	0	0.01441	0	0
KALRN	8997	broad.mit.edu	37	3	123987958	123987958	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:123987958C>T	uc003ehg.2	+	5	946	c.819C>T	c.(817-819)GAC>GAT	p.D273D	KALRN_uc010hrv.1_Silent_p.D273D|KALRN_uc003ehf.1_Silent_p.D273D|KALRN_uc011bjy.1_Silent_p.D273D	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	273	Spectrin 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GCAGTGCTGACTTCCAGAGCC	0.652			NA											18	11					0	0	0.00499	0	0
CHST13	166012	broad.mit.edu	37	3	126260868	126260869	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:126260868_126260869CC>AA	uc003eja.2	+	3	473_474	c.473_474CC>AA	c.(472-474)GCC>GAA	p.A158E		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	158	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		TTCAGCCCCGCCGAGATCAACC	0.733			NA											4	22					0	0	0.004672	0	0
ABCC5	10057	broad.mit.edu	37	3	183683279	183683279	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:183683279A>G	uc003fmg.2	-	13	2009	c.1844T>C	c.(1843-1845)CTA>CCA	p.L615P	ABCC5_uc011bqt.1_Missense_Mutation_p.L143P|ABCC5_uc010hxl.2_Missense_Mutation_p.L615P	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	615	Helical; (Potential).|ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTGCCCTCTAGAAGCGTCAT	0.507			NA											8	66					0	0	0.004482	0	0
CHRD	8646	broad.mit.edu	37	3	184106429	184106429	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:184106429G>T	uc003fov.2	+	21	2855	c.2609G>T	c.(2608-2610)CGG>CTG	p.R870L	CHRD_uc003fow.2_Missense_Mutation_p.R500L|CHRD_uc003fox.2_Missense_Mutation_p.R870L|CHRD_uc003foy.2_Missense_Mutation_p.R500L|CHRD_uc010hyc.2_Missense_Mutation_p.R460L|CHRD_uc011brr.1_Missense_Mutation_p.R412L	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	870					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATGGGCCCCGGGGCTGCCGT	0.632			NA											67	79					1.02016e-41	2.31115e-41	0.01441	1	0
ZNF141	7700	broad.mit.edu	37	4	367610	367610	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:367610C>T	uc003gaa.2	+	5	1562	c.1384C>T	c.(1384-1386)CGG>TGG	p.R462W	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	462	C2H2-type 11.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						AGCCTTTAAACGGTTCTCACA	0.333			NA											24	81					0	0	0.003954	0	0
KIAA1530	57654	broad.mit.edu	37	4	1347164	1347164	+	Silent	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:1347164C>G	uc003gde.3	+	5	1344	c.897C>G	c.(895-897)GGC>GGG	p.G299G		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	299											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			ACGGGCTGGGCTCGCACAAGT	0.682			NA											3	10					0	0	0.004672	0	0
LDB2	9079	broad.mit.edu	37	4	16590420	16590420	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:16590420G>T	uc003goz.2	-	4	760	c.444C>A	c.(442-444)ACC>ACA	p.T148T	LDB2_uc003gpa.2_Silent_p.T148T|LDB2_uc003gpb.2_Silent_p.T148T|LDB2_uc011bxh.1_Silent_p.T148T|LDB2_uc010iee.2_Silent_p.T148T|LDB2_uc003goy.2_Silent_p.T24T|LDB2_uc011bxi.1_Silent_p.T24T	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	148							LIM domain binding|transcription cofactor activity				0						GATCATCAAAGGTGAACTCCA	0.408			NA											16	66					1.5739e-10	2.77874e-10	0.004007	1	0
NFXL1	152518	broad.mit.edu	37	4	47880674	47880674	+	Silent	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:47880674T>A	uc010igh.2	-	17	2124	c.1947A>T	c.(1945-1947)CCA>CCT	p.P649P	NFXL1_uc003gxo.2_5'UTR|NFXL1_uc003gxp.2_Silent_p.P649P|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Silent_p.P649P	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	649						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GGCATGGTAGTGGACTCACCT	0.368			NA											25	64					0	0	0.005443	0	0
NDST3	9348	broad.mit.edu	37	4	119161837	119161837	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:119161837C>G	uc003ibx.2	+	11	2680	c.2277C>G	c.(2275-2277)TTC>TTG	p.F759L		NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	759	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TTGTTTATTTCCCCCCATTTC	0.448			NA											13	51					0	0	0.003163	0	0
FAT4	79633	broad.mit.edu	37	4	126371065	126371065	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:126371065G>T	uc003ifj.3	+	9	8894	c.8894G>T	c.(8893-8895)AGT>ATT	p.S2965I	FAT4_uc011cgp.1_Missense_Mutation_p.S1263I|FAT4_uc003ifi.1_Missense_Mutation_p.S443I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2965	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCCTTAATTAGTGAGACAACA	0.333			NA											26	35					6.32553e-13	1.19069e-12	0.004656	1	0
FGA	2243	broad.mit.edu	37	4	155506940	155506940	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:155506940C>A	uc003iod.1	-	5	1699	c.1641G>T	c.(1639-1641)AGG>AGT	p.R547S	FGA_uc003ioe.1_Missense_Mutation_p.R547S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	547	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ATTCTGAGCCCCTAGACTCAG	0.458	NSCLC(143;340 1922 20892 22370 48145)		NA											26	64					7.41945e-09	1.29209e-08	0.005443	1	0
KLHL2	11275	broad.mit.edu	37	4	166231753	166231753	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr4:166231753G>T	uc003irb.2	+	10	1347	c.1088G>T	c.(1087-1089)GGC>GTC	p.G363V	KLHL2_uc011cjm.1_Missense_Mutation_p.G367V|KLHL2_uc003irc.2_Missense_Mutation_p.G275V|KLHL2_uc010ira.2_Missense_Mutation_p.G16V	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	363	Kelch 2.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		GGCTTTAATGGCTCATTAAGA	0.478			NA											90	346					4.64247e-43	1.06114e-42	0.01441	1	0
PRLR	5618	broad.mit.edu	37	5	35065333	35065333	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:35065333G>A	uc003jjm.2	-	10	2257	c.1727C>T	c.(1726-1728)GCC>GTC	p.A576V	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Missense_Mutation_p.A475V	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	576	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GGCCTCTTTGGCTGATTCTTC	0.502			NA											34	56					0	0	0.003755	0	0
SLC30A5	64924	broad.mit.edu	37	5	68400536	68400536	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:68400536C>G	uc003jvh.2	+	4	553	c.352C>G	c.(352-354)CCA>GCA	p.P118A	SLC30A5_uc003jvg.2_3'UTR|SLC30A5_uc011crc.1_RNA|SLC30A5_uc003jvi.2_Intron	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	118	Helical; (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		TCTTTGTGGACCACTAAGGTA	0.289			NA											6	179					0	0	0.001984	0	0
CCNB1	891	broad.mit.edu	37	5	68473356	68473356	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:68473356C>T	uc003jvm.2	+	9	1377	c.1200C>T	c.(1198-1200)GTC>GTT	p.V400V	CCNB1_uc010ixb.2_Silent_p.V363V	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	400					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		TCCAGACTGTCAAGAACAAGT	0.368			NA											90	160					0	0	0.01441	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302275	128302275	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:128302275C>A	uc003kuy.2	+	2	841	c.445C>A	c.(445-447)CGC>AGC	p.R149S	SLC27A6_uc003kuz.2_Missense_Mutation_p.R149S	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	149					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GAATTGCATCCGCGCCTGTGG	0.587			NA											12	23					7.93312e-07	1.30185e-06	0.00245	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480848	140480848	+	Silent	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:140480848G>A	uc003lio.2	+	1	615	c.615G>A	c.(613-615)CAG>CAA	p.Q205Q	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	205	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGAGGAGCAGCCGGAACTCA	0.562			NA											41	76					0	0	0.009718	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140734986	140734986	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:140734986G>T	uc003ljq.1	+	1	219	c.219G>T	c.(217-219)CAG>CAT	p.Q73H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.Q73H	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	73	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAGGACGCAGCTTTTCGCCC	0.637			NA											9	137					7.48243e-07	1.24383e-06	0.006214	1	0
PCDHGB2	56103	broad.mit.edu	37	5	140740860	140740860	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:140740860G>T	uc003ljs.1	+	1	1158	c.1158G>T	c.(1156-1158)GTG>GTT	p.V386V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.V386V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	386	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCCAAGTGTTGGGAAATG	0.463			NA											49	86					2.13384e-23	4.3701e-23	0.01441	1	0
SLC36A1	206358	broad.mit.edu	37	5	150844717	150844717	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:150844717G>A	uc003luc.2	+	5	623	c.406G>A	c.(406-408)GCA>ACA	p.A136T	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.A136T|SLC36A1_uc010jhw.1_Missense_Mutation_p.A136T	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	136	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCGGAACCACGCACACTGGGG	0.493	Melanoma(151;1534 1860 12947 32979 37872)		NA											15	132					0	0	0.00499	0	0
GABRA6	2559	broad.mit.edu	37	5	161128527	161128527	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:161128527G>T	uc003lyu.2	+	9	1448	c.1110G>T	c.(1108-1110)CTG>CTT	p.L370L	GABRA6_uc003lyv.2_Silent_p.L141L	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	370	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AATATCATCTGAAGAAAAGGA	0.383			NA								TCGA Ovarian(5;0.080)			77	133					1.59627e-33	3.49269e-33	0.01441	1	0
HRH2	3274	broad.mit.edu	37	5	175111225	175111225	+	Missense_Mutation	SNP	G	G	A	rs141845922		TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr5:175111225G>A	uc003mdd.2	+	1	2762	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	HRH2_uc003mdc.3_Missense_Mutation_p.R330Q	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	330	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	ACCCAAAGCCGAGAACCCAGG	0.592			NA											5	167					0	0	0.000602	0	0
CLIC1	1192	broad.mit.edu	37	6	31700099	31700099	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:31700099A>C	uc003nwr.2	-	5	723	c.459T>G	c.(457-459)GAT>GAG	p.D153E	DDAH2_uc003nwp.2_5'Flank|DDAH2_uc003nwq.2_5'Flank|CLIC1_uc003rje.2_Missense_Mutation_p.D153E	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	153	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						CACTGGTTTCATCCACTTCTT	0.478			NA											10	123					0	0	0.006214	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170343	32170343	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:32170343G>T	uc003obb.2	-	21	3404	c.3265C>A	c.(3265-3267)CCT>ACT	p.P1089T	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1089	EGF-like 28.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCGCAGGAAGGGGCCCTGTGG	0.607			NA											8	16					3.09899e-07	5.18523e-07	0.004482	1	0
LRFN2	57497	broad.mit.edu	37	6	40399871	40399871	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:40399871G>T	uc003oph.1	-	2	1447	c.982C>A	c.(982-984)CGC>AGC	p.R328S		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	328	Extracellular (Potential).|Ig-like.					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTACCAGGCGGTCATCGGGG	0.587			NA											12	25					5.50884e-06	8.98256e-06	0.013537	1	0
TREML2	79865	broad.mit.edu	37	6	41166018	41166018	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:41166018G>T	uc010jxm.1	-	2	384	c.205C>A	c.(205-207)CGA>AGA	p.R69R		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	69	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACCCAGACTCGGGCAAAGCCA	0.577			NA											34	91					5.91797e-21	1.19291e-20	0.012213	1	0
TFAP2B	7021	broad.mit.edu	37	6	50807918	50807918	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:50807918G>T	uc003pag.2	+	6	1156	c.990G>T	c.(988-990)GAG>GAT	p.E330D		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	330					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GCGAAACGGAGTTTCCCGCCA	0.483	Pancreas(116;1373 2332 5475 10752)		NA											58	144					2.93687e-30	6.31798e-30	0.01441	1	0
B3GAT2	135152	broad.mit.edu	37	6	71665881	71665881	+	Silent	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:71665881G>A	uc003pfv.2	-	1	908	c.252C>T	c.(250-252)GCC>GCT	p.A84A	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Silent_p.A84A	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	84	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGGGCGTGATGGCATAGATGG	0.701			NA											8	35					0	0	0.006214	0	0
MDN1	23195	broad.mit.edu	37	6	90424410	90424410	+	Silent	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:90424410T>A	uc003pnn.1	-	46	7037	c.6921A>T	c.(6919-6921)GGA>GGT	p.G2307G		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2307					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGATTTCAAGTCCACGATTCC	0.418			NA											21	52					0	0	0.008871	0	0
EYA4	2070	broad.mit.edu	37	6	133783899	133783899	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:133783899C>T	uc003qec.3	+	9	1179	c.721C>T	c.(721-723)CCA>TCA	p.P241S	EYA4_uc011ecq.1_Missense_Mutation_p.P187S|EYA4_uc011ecr.1_Missense_Mutation_p.P187S|EYA4_uc003qed.3_Missense_Mutation_p.P241S|EYA4_uc003qee.3_Missense_Mutation_p.P218S|EYA4_uc011ecs.1_Missense_Mutation_p.P241S|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	241					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TTACCAAATGCCAGGTAAGTA	0.453	Melanoma(57;398 1237 3528 4702 7415)		NA											21	45					0	0	0.003954	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151161073	151161073	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:151161073C>T	uc003qny.1	+	17	3511	c.3199C>T	c.(3199-3201)CTC>TTC	p.L1067F	PLEKHG1_uc011eem.1_Missense_Mutation_p.L1126F	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1067					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AGAATCCTCCCTCCTGAGGTC	0.493			NA											17	52					0	0	0.00499	0	0
T	6862	broad.mit.edu	37	6	166578318	166578318	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:166578318A>C	uc003quu.1	-	5	1131	c.638T>G	c.(637-639)TTT>TGT	p.F213C	T_uc003qut.1_Missense_Mutation_p.F213C|T_uc003quv.1_Missense_Mutation_p.F213C	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	213	T-box.				anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGCTTTTGCAAATGGATTGTA	0.348			NA							Chordoma_Familial_Clustering_of				16	42					0	0	0.007413	0	0
GPR31	2853	broad.mit.edu	37	6	167570422	167570422	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr6:167570422G>T	uc011egq.1	-	1	898	c.898C>A	c.(898-900)CTC>ATC	p.L300I		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	300	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		TTGCCTCGGAGGGTGTGGAAG	0.592			NA											20	42					2.39187e-15	4.63878e-15	0.008871	1	0
TWISTNB	221830	broad.mit.edu	37	7	19748635	19748635	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:19748635G>A	uc003sup.1	-	1	26	c.5C>T	c.(4-6)GCT>GTT	p.A2V		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	2						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						GCAACCTGCAGCCATGCTGCT	0.652			NA									OREG0017879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	35					0	0	0.001168	0	0
PDE1C	5137	broad.mit.edu	37	7	31876892	31876892	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:31876892A>C	uc003tcm.1	-	11	1574	c.1105T>G	c.(1105-1107)TCC>GCC	p.S369A	PDE1C_uc003tcn.1_Missense_Mutation_p.S369A|PDE1C_uc003tco.1_Missense_Mutation_p.S429A|PDE1C_uc003tcr.2_Missense_Mutation_p.S369A|PDE1C_uc003tcs.2_Missense_Mutation_p.S369A	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	369	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AGCATAAGGGATAAGGCTTTT	0.423			NA											23	32					0	0	0.012319	0	0
TBX20	57057	broad.mit.edu	37	7	35271147	35271147	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:35271147G>T	uc011kas.1	-	6	870	c.859C>A	c.(859-861)CGG>AGG	p.R287R		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	287	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						GAGGAATCCCGGAATCCTTTG	0.378			NA											15	40					1.15088e-07	1.96416e-07	0.004007	1	0
INHBA	3624	broad.mit.edu	37	7	41729798	41729798	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:41729798C>T	uc003thq.2	-	2	966	c.731G>A	c.(730-732)TGT>TAT	p.C244Y	INHBA_uc003thr.2_Missense_Mutation_p.C244Y	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	244					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						GCACTGCTCACAGGCAATCCG	0.448			NA								TSP Lung(11;0.080)			6	50					0	0	0.001984	0	0
AGFG2	3268	broad.mit.edu	37	7	100151829	100151829	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:100151829C>T	uc003uvf.2	+	5	835	c.699C>T	c.(697-699)CCC>CCT	p.P233P	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Missense_Mutation_p.P95L	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	233					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						GTGGAGACCCCTTTGCTGCAC	0.582			NA											21	33					0	0	0.008871	0	0
ZNF800	168850	broad.mit.edu	37	7	127013680	127013680	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:127013680A>T	uc003vlx.1	-	5	1973	c.1710T>A	c.(1708-1710)AAT>AAA	p.N570K	ZNF800_uc003vlw.1_Missense_Mutation_p.N473K|ZNF800_uc003vly.1_Missense_Mutation_p.N570K|ZNF800_uc010lla.2_Missense_Mutation_p.N570K	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTGCCACTTTATTTAGAACAA	0.353			NA											32	72					0	0	0.008361	0	0
TNPO3	23534	broad.mit.edu	37	7	128655115	128655115	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:128655115C>A	uc003vol.1	-	4	844	c.470G>T	c.(469-471)CGT>CTT	p.R157L	TNPO3_uc003vom.1_Missense_Mutation_p.R91L|TNPO3_uc010lly.1_Missense_Mutation_p.R157L|TNPO3_uc010llz.1_Missense_Mutation_p.R157L	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	157					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TCGTAAGGAACGACTATGTAC	0.378	Pancreas(147;583 2585 39696 52331)		NA											11	76					2.27111e-07	3.82503e-07	0.013537	1	0
TRPV6	55503	broad.mit.edu	37	7	142574906	142574906	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:142574906A>T	uc003wbx.1	-	4	692	c.476T>A	c.(475-477)CTC>CAC	p.L159H	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_Missense_Mutation_p.L30H	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	159	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					AAAGTAGATGAGGTTGCAGGG	0.383			NA											11	44					0	0	0.010729	0	0
MYOM2	9172	broad.mit.edu	37	8	2037867	2037867	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:2037867G>T	uc003wpx.3	+	15	1819	c.1681G>T	c.(1681-1683)GCC>TCC	p.A561S	MYOM2_uc011kwi.1_5'UTR	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	561	Fibronectin type-III 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GAGAGTCAACGCCCAGACGGC	0.577			NA											28	57					3.73148e-12	6.82327e-12	0.007291	1	0
PXDNL	137902	broad.mit.edu	37	8	52323848	52323848	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:52323848C>G	uc003xqu.3	-	16	2125	c.2024G>C	c.(2023-2025)CGT>CCT	p.R675P	PXDNL_uc003xqt.3_5'Flank	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	675					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGCTTCACACGTTCCCGTAT	0.517			NA											8	30					0	0	0.00308	0	0
TRPA1	8989	broad.mit.edu	37	8	72975784	72975784	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:72975784C>G	uc003xza.2	-	5	750	c.575G>C	c.(574-576)TGT>TCT	p.C192S		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	192	Cytoplasmic (Potential).|ANK 4.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ATTTGATTTACATGGCTTAGC	0.383			NA											35	89					0	0	0.006999	0	0
LRP12	29967	broad.mit.edu	37	8	105521219	105521219	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:105521219T>A	uc003yma.2	-	3	315	c.220A>T	c.(220-222)ATC>TTC	p.I74F	LRP12_uc003ymb.2_Missense_Mutation_p.I55F|LRP12_uc003ymc.3_Missense_Mutation_p.I55F	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	74	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTACAGTTGATTTTTGCAGGA	0.398			NA											6	231					0	0	0.001984	0	0
CSMD3	114788	broad.mit.edu	37	8	113237150	113237150	+	Silent	SNP	A	A	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:113237150A>T	uc003ynu.2	-	71	11133	c.10974T>A	c.(10972-10974)CCT>CCA	p.P3658P	CSMD3_uc003yns.2_Silent_p.P2860P|CSMD3_uc003ynt.2_Silent_p.P3618P|CSMD3_uc011lhx.1_Silent_p.P3489P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3658	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTGTGTTTTAGGTGCAGTCC	0.393			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	242					0	0	0.014323	0	0
TRPS1	7227	broad.mit.edu	37	8	116426992	116426992	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:116426992C>A	uc003ynz.2	-	6	3564	c.3105G>T	c.(3103-3105)TTG>TTT	p.L1035F	TRPS1_uc011lhy.1_Missense_Mutation_p.L1039F|TRPS1_uc003yny.2_Missense_Mutation_p.L1048F|TRPS1_uc010mcy.2_Missense_Mutation_p.L1035F	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1035	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCTGAATGTGCAAAGGTTGCA	0.448			NA							Langer-Giedion_syndrome				127	150					9.50027e-55	2.21097e-54	0.01441	1	0
PTK2	5747	broad.mit.edu	37	8	141745432	141745432	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:141745432T>C	uc003yvu.2	-	22	2178	c.1948A>G	c.(1948-1950)ACC>GCC	p.T650A	PTK2_uc003yvo.2_Missense_Mutation_p.T278A|PTK2_uc011ljq.1_Missense_Mutation_p.T345A|PTK2_uc003yvp.2_Missense_Mutation_p.T318A|PTK2_uc003yvq.2_Missense_Mutation_p.T176A|PTK2_uc003yvr.2_Missense_Mutation_p.T590A|PTK2_uc003yvs.2_Missense_Mutation_p.T650A|PTK2_uc003yvt.2_Missense_Mutation_p.T672A|PTK2_uc003yvv.2_Missense_Mutation_p.T550A|PTK2_uc011ljr.1_Missense_Mutation_p.T650A|MIR151_hsa-mir-151|MI0000809_5'Flank	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	650	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CTGTAGAGGGTAGGAGGACAA	0.488			NA											52	53					0	0	0.01441	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996585	143996585	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr8:143996585G>T	uc003yxk.1	-	3	475	c.472C>A	c.(472-474)CTC>ATC	p.L158I		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	158					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	ACCATCGGGAGGAACCTCTGC	0.637			NA							Familial_Hyperaldosteronism_type_I				13	38					7.93312e-07	1.30185e-06	0.00245	1	0
CNTFR	1271	broad.mit.edu	37	9	34557978	34557978	+	Silent	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr9:34557978C>T	uc003zup.1	-	5	605	c.324G>A	c.(322-324)CCG>CCA	p.P108P	CNTFR_uc003zuq.1_Silent_p.P108P	NM_147164	NP_671693	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	108	Fibronectin type-III 1.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			ovary(3)|central_nervous_system(1)|skin(1)	5	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		GCTCCCGCGGCGGCACTGGGG	0.642			NA											17	101					0	0	0.006122	0	0
Unknown	0	broad.mit.edu	37	9	40503105	40503105	+	Missense_Mutation	SNP	G	G	C	rs149697531	by1000genomes	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr9:40503105G>C	uc004abr.1	-	6	820	c.577C>G	c.(577-579)CAC>GAC	p.H193D						RecName: Full=Contactin-associated protein-like 3B; AltName: Full=Cell recognition molecule Caspr3b; Flags: Precursor;												NA						ACCTGCGTGTGGAGGAGCTCG	0.488			NA											13	24					0	0	0.00245	0	0
DFNB31	25861	broad.mit.edu	37	9	117165060	117165060	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr9:117165060C>A	uc004biz.3	-	12	3347	c.2698G>T	c.(2698-2700)GTC>TTC	p.V900F	DFNB31_uc004bix.2_Missense_Mutation_p.V549F|DFNB31_uc004biy.3_Missense_Mutation_p.V517F|DFNB31_uc004bja.3_Missense_Mutation_p.V899F	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	900					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						AACTCAGTGACCAGAAAGTCA	0.592			NA											38	63					9.80977e-26	2.04171e-25	0.004289	1	0
AGPAT2	10555	broad.mit.edu	37	9	139571431	139571431	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr9:139571431C>G	uc004cii.1	-	3	576	c.474G>C	c.(472-474)GAG>GAC	p.E158D	AGPAT2_uc004cij.1_Missense_Mutation_p.E158D	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	158					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		TGACCATGCGCTCGCCCAGGT	0.667			NA											8	90					0	0	0.00308	0	0
FAM123B	139285	broad.mit.edu	37	X	63411180	63411180	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:63411180C>T	uc004dvo.2	-	2	2260	c.1987G>A	c.(1987-1989)GTG>ATG	p.V663M		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	663					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						AGGCCCATCACTGATGGGCCT	0.597			NA											5	49					0	0	0.000602	0	0
AWAT2	158835	broad.mit.edu	37	X	69261742	69261742	+	Silent	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:69261742G>T	uc004dxt.1	-	7	924	c.918C>A	c.(916-918)CTC>CTA	p.L306L		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	306						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						CATCAATATAGAGTGTGTGAT	0.483	NSCLC(80;1334 1436 9350 24214 26427)		NA											41	90					6.2361e-21	1.23755e-20	0.007835	1	0
MED12	9968	broad.mit.edu	37	X	70347271	70347271	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:70347271T>C	uc004dyy.2	+	21	3134	c.2935T>C	c.(2935-2937)TAC>CAC	p.Y979H	MED12_uc011mpq.1_Missense_Mutation_p.Y979H|MED12_uc004dyz.2_Missense_Mutation_p.Y979H|MED12_uc004dza.2_Missense_Mutation_p.Y826H|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	979					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CTATGATCTGTACACCTCCTG	0.517			NA											7	112					0	0	0.001984	0	0
RGAG4	340526	broad.mit.edu	37	X	71349706	71349706	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:71349706G>T	uc010nlh.1	-	1	2046	c.1685C>A	c.(1684-1686)GCT>GAT	p.A562D	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	562										ovary(2)|skin(1)	3	Renal(35;0.156)					GCCACGAGCAGCTCGGTGGCC	0.612			NA											25	48					1.64293e-13	3.11549e-13	0.00333	1	0
FAM46D	169966	broad.mit.edu	37	X	79698296	79698296	+	Silent	SNP	T	T	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:79698296T>A	uc004edl.1	+	5	592	c.258T>A	c.(256-258)ATT>ATA	p.I86I	FAM46D_uc004edm.1_Silent_p.I86I	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	86										lung(2)	2						TGGACGTTATTTTTGGTGTTG	0.378			NA											52	100					0	0	0.01441	0	0
PCDH19	57526	broad.mit.edu	37	X	99661991	99661991	+	Silent	SNP	G	G	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:99661991G>A	uc010nmz.2	-	1	3281	c.1605C>T	c.(1603-1605)GCC>GCT	p.A535A	PCDH19_uc004efw.3_Silent_p.A535A|PCDH19_uc004efx.3_Silent_p.A535A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	535	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CGCCGTCCTTGGCCAGCACCT	0.572			NA											98	160					0	0	0.01441	0	0
GUCY2F	2986	broad.mit.edu	37	X	108638636	108638636	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:108638636C>A	uc004eod.3	-	12	2634	c.2358G>T	c.(2356-2358)CAG>CAT	p.Q786H	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	786	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						GCTTCATCAGCTGGAGACATT	0.478			NA											112	179					2.2063e-47	5.0884e-47	0.01441	1	0
TRPC5	7224	broad.mit.edu	37	X	111097166	111097166	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:111097166C>A	uc004epl.1	-	4	1988	c.1069G>T	c.(1069-1071)GGG>TGG	p.G357W	TRPC5_uc004epm.1_Missense_Mutation_p.G357W	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	357	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						ATGAACAGCCCAAGGTTGCTC	0.478			NA											51	87					3.68337e-26	7.72904e-26	0.01441	1	0
BCORL1	63035	broad.mit.edu	37	X	129148663	129148663	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:129148663C>A	uc004evb.1	+	4	2029	c.1915C>A	c.(1915-1917)CGC>AGC	p.R639S	BCORL1_uc010nrd.1_Missense_Mutation_p.R541S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	639	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GCCGAACCAGCGCAAGACACC	0.612			NA											21	111					1.28384e-07	2.17657e-07	0.012319	1	0
MAGEC1	9947	broad.mit.edu	37	X	140994335	140994335	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:140994335C>G	uc004fbt.2	+	4	1431	c.1145C>G	c.(1144-1146)TCC>TGC	p.S382C	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	382							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTCCTTCTCCTCCACTTTA	0.483			NA								HNSCC(15;0.026)			75	369					0	0	0.01441	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290894	141290894	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:141290894G>T	uc004fbu.1	-	3	1228	c.880C>A	c.(880-882)CCT>ACT	p.P294T		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	294	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TAATATGGAGGAGAACTGTGG	0.502			NA								HNSCC(46;0.14)			19	184					2.39187e-15	4.63878e-15	0.008871	1	0
MAMLD1	10046	broad.mit.edu	37	X	149638271	149638271	+	Silent	SNP	C	C	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chrX:149638271C>A	uc004fee.1	+	3	502	c.426C>A	c.(424-426)GGC>GGA	p.G142G	MAMLD1_uc011mxt.1_Silent_p.G104G|MAMLD1_uc011mxu.1_Silent_p.G117G|MAMLD1_uc011mxv.1_Silent_p.G117G|MAMLD1_uc011mxw.1_Silent_p.G69G	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	142					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					ACATCATGGGCTCACCATTTG	0.507			NA											60	121					5.47352e-35	1.20795e-34	0.01441	1	0
DOCK1	1793	broad.mit.edu	37	10	129172131	129172134	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	GTAA	GTAA	-	-	GTAA	GTAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr10:129172131_129172134delGTAA	uc001ljt.2	+	34	3519	c.3455_splice	c.e34+1	p.I1152_splice	DOCK1_uc010qun.1_Splice_Site_p.I1173_splice|DOCK1_uc009yaq.2_Splice_Site_p.I147_splice	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1						apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TTGATAAAATGTAAGTGTTGATTA	0.358			NA											8	22	---	---	---	---	NA	NA	NA	NA	NA
NUP160	23279	broad.mit.edu	37	11	47819339	47819340	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr11:47819339_47819340insA	uc001ngm.2	-	27	3365_3366	c.3280_3281insT	c.(3280-3282)TACfs	p.Y1094fs	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1094					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						ACCCTTGCGGTAATTGTGGCGA	0.391			NA											45	62	---	---	---	---	NA	NA	NA	NA	NA
SLC5A11	115584	broad.mit.edu	37	16	24921737	24921739	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:24921737_24921739delCAG	uc002dmu.2	+	15	1993_1995	c.1761_1763delCAG	c.(1759-1764)GCCAGC>GCC	p.S592del	SLC5A11_uc002dms.2_In_Frame_Del_p.S528del|SLC5A11_uc010vcd.1_In_Frame_Del_p.S557del|SLC5A11_uc002dmt.2_In_Frame_Del_p.S436del|SLC5A11_uc010vce.1_In_Frame_Del_p.S522del|SLC5A11_uc010bxt.2_In_Frame_Del_p.S528del|SLC5A11_uc002dmv.2_In_Frame_Del_p.S215del	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	592	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		TGCCAGAGGCCAGCAGCAGCAGC	0.542			NA											8	108	---	---	---	---	NA	NA	NA	NA	NA
NLRC5	84166	broad.mit.edu	37	16	57111872	57111872	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr16:57111872delT	uc002ekk.1	+	43	5246	c.5021delT	c.(5020-5022)CTGfs	p.L1674fs	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Frame_Shift_Del_p.L216fs|NLRC5_uc002ekr.1_Frame_Shift_Del_p.L561fs	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1674	LRR 22.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TGCAATGCCCTGGGGGATCCC	0.677			NA											9	45	---	---	---	---	NA	NA	NA	NA	NA
NLRP4	147945	broad.mit.edu	37	19	56382227	56382227	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr19:56382227delG	uc002qmd.3	+	7	2811	c.2389delG	c.(2389-2391)GAAfs	p.E797fs	NLRP4_uc002qmf.2_Frame_Shift_Del_p.E722fs|NLRP4_uc010etf.2_Frame_Shift_Del_p.E572fs	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	797							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCAGTGCTGCGAATACATCTC	0.512			NA											42	41	---	---	---	---	NA	NA	NA	NA	NA
HADHA	3030	broad.mit.edu	37	2	26455076	26455076	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:26455076delC	uc002rgy.2	-	6	655	c.525delG	c.(523-525)TTGfs	p.L175fs	HADHA_uc010yks.1_Frame_Shift_Del_p.L88fs|HADHA_uc010ykt.1_Frame_Shift_Del_p.L88fs	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	175					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGGCCCCCAGCAAAACTTCAG	0.418			NA											7	94	---	---	---	---	NA	NA	NA	NA	NA
HEATR5B	54497	broad.mit.edu	37	2	37276863	37276864	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr2:37276863_37276864insA	uc002rpp.1	-	18	2724_2725	c.2628_2629insT	c.(2626-2631)CTTGGAfs	p.L876fs		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	876_877	HEAT 1.						binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GCCATTCTTCCAAGAGCTTCCC	0.46			NA											44	58	---	---	---	---	NA	NA	NA	NA	NA
PLCB4	5332	broad.mit.edu	37	20	9449216	9449221	+	Splice_Site	DEL	AGGGAA	AGGGAA	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	AGGGAA	AGGGAA	-	-	AGGGAA	AGGGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr20:9449216_9449221delAGGGAA	uc002wnf.2	+	34	3349	c.3213_splice	c.e34-1	p.R1071_splice	PLCB4_uc010gbx.2_Splice_Site_p.R1083_splice|PLCB4_uc002wne.2_Splice_Site_p.R1071_splice|PLCB4_uc002wnh.2_Splice_Site_p.R918_splice	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b						intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTTAATACATAGGGAAAGCAAGGAAA	0.238			NA											25	144	---	---	---	---	NA	NA	NA	NA	NA
MUC4	4585	broad.mit.edu	37	3	195515367	195515414	+	In_Frame_Del	DEL	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	-	rs13065584	by1000genomes	TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	-	-	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	GGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr3:195515367_195515414delGGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCT	uc011bto.1	-	2	3497_3544	c.3037_3084delAGCCCTTCCTCAGTATCCACAGGTCACACCACCCCTCTTCCTGTCACC	c.(3037-3084)AGCCCTTCCTCAGTATCCACAGGTCACACCACCCCTCTTCCTGTCACCdel	p.SPSSVSTGHTTPLPVT1013del	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1013_1029	Repeat.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGTGTCGGTGACAGGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGGGCTGGTGACAGGA	0.573			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5051-01A-21D-1855-08	TCGA-50-5051-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	bb50bc27-fb18-4eee-8785-b8e8b69bcbe6	91ddece4-7730-4739-9b9f-ded43a5dd8ab	g.chr7:44684936delT	uc003tln.2	+	3	342	c.233delT	c.(232-234)ATTfs	p.I78fs	OGDH_uc003tlm.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbx.1_Frame_Shift_Del_p.I78fs|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbz.1_5'UTR|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577			NA											7	283	---	---	---	---	NA	NA	NA	NA	NA
