Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VWA1	64856	broad.mit.edu	37	1	1372746	1372746	+	Silent	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:1372746C>A	uc001afs.2	+	2	733	c.513C>A	c.(511-513)GGC>GGA	p.G171G	VWA1_uc001afr.2_5'UTR	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	171	VWFA.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCAGCACCGGCCGAGGCAACT	0.632			NA											15	5					3.45872e-05	3.84302e-05	0.028581	1	0
C1orf94	84970	broad.mit.edu	37	1	34666416	34666416	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:34666416C>A	uc001bxs.3	+	3	882	c.483C>A	c.(481-483)AGC>AGA	p.S161R	C1orf94_uc001bxt.2_Missense_Mutation_p.S351R	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	161							protein binding				0		Myeloproliferative disorder(586;0.0393)				GTCAAGGGAGCCTCTTTCTCA	0.592			NA											36	7					2.47316e-13	3.40059e-13	0.015359	1	0
TMEM53	79639	broad.mit.edu	37	1	45120854	45120854	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:45120854G>A	uc001cmc.2	-	3	247	c.211C>T	c.(211-213)CCG>TCG	p.P71S	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_5'UTR|TMEM53_uc009vxh.1_Intron|TMEM53_uc010ola.1_Intron	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	71						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					ATGTGCCACGGGGCTGTGTAT	0.552			NA									OREG0013446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	29					0	0	0.024245	0	0
INADL	10207	broad.mit.edu	37	1	62235060	62235060	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:62235060G>T	uc001dab.2	+	5	604	c.490G>T	c.(490-492)GTG>TTG	p.V164L	INADL_uc009waf.1_Missense_Mutation_p.V164L|INADL_uc001daa.2_Missense_Mutation_p.V164L|INADL_uc001dad.3_5'Flank	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	164	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TGATATCTTCGTGAAGGATGT	0.398			NA											63	87					1.38705e-31	2.4609e-31	0.01441	1	0
SF3B4	10262	broad.mit.edu	37	1	149898433	149898433	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:149898433C>G	uc001etj.1	-	3	592	c.541G>C	c.(541-543)GAC>CAC	p.D181H	SF3B4_uc001eti.1_5'Flank|SF3B4_uc001etk.1_Missense_Mutation_p.D181H|SF3B4_uc009wll.1_Missense_Mutation_p.D181H	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	181						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CCCTTGGAGTCCTTCTTGAAG	0.522			NA											34	43					0	0	0.017118	0	0
IL6R	3570	broad.mit.edu	37	1	154401899	154401899	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:154401899A>T	uc001fez.1	+	2	750	c.313A>T	c.(313-315)ACT>TCT	p.T105S	IL6R_uc001ffa.1_Missense_Mutation_p.T105S	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	105	Extracellular (Potential).|Ig-like C2-type.				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCCAGCTGGGACTGTGCACTT	0.587			NA											38	16					0	0	0.007835	0	0
VHLL	391104	broad.mit.edu	37	1	156268923	156268923	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:156268923C>A	uc001fok.2	-	1	506	c.58G>T	c.(58-60)GCA>TCA	p.A20S		NM_001004319	NP_001004319	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	20					protein ubiquitination	nucleus				ovary(1)	1	Hepatocellular(266;0.158)					TCTGGGCCTGCCTCCTGGGTG	0.637			NA											27	78					2.2171e-23	3.75202e-23	0.009535	1	0
TNN	63923	broad.mit.edu	37	1	175048765	175048765	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:175048765G>T	uc001gkl.1	+	3	819	c.706G>T	c.(706-708)GAC>TAC	p.D236Y	TNN_uc010pmx.1_Missense_Mutation_p.D236Y	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	236	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTGTCCCGGCGACTGCAGCGG	0.667			NA											13	6					4.3838e-07	5.18514e-07	0.016723	1	0
RYR2	6262	broad.mit.edu	37	1	237777543	237777543	+	Silent	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:237777543G>T	uc001hyl.1	+	37	5235	c.5115G>T	c.(5113-5115)CTG>CTT	p.L1705L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1705	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTATGACCTGCTGATTGACA	0.537			NA											60	24					3.07184e-27	5.36353e-27	0.01441	1	0
ABCC2	1244	broad.mit.edu	37	10	101560182	101560182	+	Silent	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr10:101560182G>A	uc001kqf.2	+	9	1210	c.1071G>A	c.(1069-1071)TTG>TTA	p.L357L		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	357	ABC transmembrane type-1 1.|Extracellular (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACACATATTTGTGGATTGGAT	0.453			NA											161	221					0	0	0.01441	0	0
GRK5	2869	broad.mit.edu	37	10	121196346	121196346	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr10:121196346G>A	uc001led.2	+	9	1155	c.922G>A	c.(922-924)GTC>ATC	p.V308I	GRK5_uc009xzh.2_Missense_Mutation_p.V203I|GRK5_uc010qta.1_Missense_Mutation_p.V203I	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	308	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TGAGAACACCGTCTACCGGTG	0.607			NA											10	9					0	0	0.006214	0	0
MKI67	4288	broad.mit.edu	37	10	129903806	129903806	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr10:129903806T>C	uc001lke.2	-	13	6493	c.6298A>G	c.(6298-6300)AAA>GAA	p.K2100E	MKI67_uc001lkf.2_Missense_Mutation_p.K1740E|MKI67_uc009yav.1_Missense_Mutation_p.K1675E|MKI67_uc009yaw.1_Missense_Mutation_p.K1250E	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2100	16 X 122 AA approximate repeats.|10.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAGGCTATTTTGGTAGTTTTG	0.483			NA											161	224					0	0	0.01441	0	0
MKI67	4288	broad.mit.edu	37	10	129905293	129905293	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr10:129905293G>C	uc001lke.2	-	13	5006	c.4811C>G	c.(4810-4812)TCA>TGA	p.S1604*	MKI67_uc001lkf.2_Nonsense_Mutation_p.S1244*|MKI67_uc009yav.1_Nonsense_Mutation_p.S1179*|MKI67_uc009yaw.1_Nonsense_Mutation_p.S754*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1604	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTTAGTCATTGATTCCTCAGT	0.498			NA											79	119					0	0	0.01441	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128838914	128838914	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr11:128838914G>A	uc009zcp.2	-	22	6152	c.6152C>T	c.(6151-6153)CCT>CTT	p.P2051L	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.P1010L|ARHGAP32_uc001qez.2_Missense_Mutation_p.P1702L	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2051	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGGAAAGCCAGGGGGCACATA	0.577			NA											6	4					0	0	0.001984	0	0
KCNA5	3741	broad.mit.edu	37	12	5154154	5154155	+	Nonsense_Mutation	DNP	CT	CT	TA			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr12:5154154_5154155CT>TA	uc001qni.2	+	1	1070_1071	c.841_842CT>TA	c.(841-843)CTG>TAG	p.L281*		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	281						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						TGAACGTGAGCTGCTCCGCCAC	0.693			NA											17	44					0	0	0.004672	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			15	14					0.00400662	0.00419742	0.028581	1	0
IPO8	10526	broad.mit.edu	37	12	30814173	30814173	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr12:30814173T>A	uc001rjd.2	-	16	1953	c.1783A>T	c.(1783-1785)AGT>TGT	p.S595C	IPO8_uc001rje.1_Missense_Mutation_p.S84C|IPO8_uc010sjt.1_Missense_Mutation_p.S390C	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	595					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TATTCATCACTTTGAAGAACT	0.328			NA											28	28					0	0	0.027356	0	0
CCDC41	51134	broad.mit.edu	37	12	94772782	94772782	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr12:94772782T>C	uc001tdd.2	-	7	1172	c.586A>G	c.(586-588)AAC>GAC	p.N196D	CCDC41_uc001tde.2_Missense_Mutation_p.N196D|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.N196D	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	188	Potential.										0						AGCAGCTGGTTACGTAGTTCT	0.328			NA											55	28					0	0	0.01441	0	0
SOHLH2	54937	broad.mit.edu	37	13	36788621	36788621	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr13:36788621C>T	uc001uvj.2	-	1	132	c.43G>A	c.(43-45)GGC>AGC	p.G15S	SOHLH2_uc010tei.1_Intron	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	15					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CTTACCTGGCCCGAGATCTGG	0.672			NA											4	6					0	0	0.009096	0	0
TFDP1	7027	broad.mit.edu	37	13	114290924	114290925	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr13:114290924_114290925GG>TT	uc001vtw.2	+	10	1127_1128	c.915_916GG>TT	c.(913-918)ATGGCT>ATTTCT	p.305_306MA>IS	TFDP1_uc010tkd.1_Missense_Mutation_p.210_211MA>IS|TFDP1_uc010tke.1_Missense_Mutation_p.210_211MA>IS|TFDP1_uc001vty.3_Missense_Mutation_p.305_306MA>IS|TFDP1_uc001vtx.2_Missense_Mutation_p.185_186MA>IS	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	305_306	DCB2.|Enhances binding of RB protein to E2F.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			GGATGGGCATGGCTTGCGGGCT	0.505			NA								TSP Lung(29;0.18)			27	43					0	0	0.004672	0	0
OR4M2	390538	broad.mit.edu	37	15	22368728	22368728	+	Silent	SNP	A	A	G			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr15:22368728A>G	uc010tzu.1	+	1	153	c.153A>G	c.(151-153)CTA>CTG	p.L51L	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCATCAGTCTAGACCCTCATC	0.418			NA											97	814					0	0	0.01441	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40284993	40284993	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr15:40284993A>T	uc001zkm.1	+	18	2760	c.2710A>T	c.(2710-2712)ACT>TCT	p.T904S	EIF2AK4_uc010bbj.1_Missense_Mutation_p.T605S|EIF2AK4_uc001zkn.1_Missense_Mutation_p.T4S	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	904	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GATGGTTGGCACTGCTCTCTA	0.418			NA											37	50					0	0	0.00874	0	0
ADAM10	102	broad.mit.edu	37	15	58889786	58889786	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr15:58889786C>A	uc002afd.1	-	16	2651	c.2207G>T	c.(2206-2208)CGG>CTG	p.R736L	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.R435L|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	736	Cytoplasmic (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		CTCTCGGGGCCGCTGACGCTG	0.478			NA											21	35					3.28513e-13	4.46128e-13	0.021523	1	0
Unknown	0	broad.mit.edu	37	15	76074431	76074431	+	Missense_Mutation	SNP	C	C	T	rs149323153	by1000genomes	TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr15:76074431C>T	uc010umm.1	+	8	610	c.533C>T	c.(532-534)TCG>TTG	p.S178L	uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;												NA						CTCCAGTCCTCGAGCTGCAGA	0.547			NA											3	26					0	0	0.021553	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											3	11					0	0	0.009096	0	0
ADCY9	115	broad.mit.edu	37	16	4057495	4057495	+	Silent	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr16:4057495G>A	uc002cvx.2	-	3	2297	c.1758C>T	c.(1756-1758)GCC>GCT	p.A586A		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	586	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CAGAAAGCAAGGCCTCTGCAC	0.527			NA											32	41					0	0	0.010818	0	0
ZNF276	92822	broad.mit.edu	37	16	89795695	89795695	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr16:89795695G>T	uc002fos.3	+	6	1235	c.1138G>T	c.(1138-1140)GAC>TAC	p.D380Y	ZNF276_uc010ciq.2_Missense_Mutation_p.D166Y|ZNF276_uc002fop.2_Missense_Mutation_p.D288Y|ZNF276_uc002foq.3_Missense_Mutation_p.D305Y|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Missense_Mutation_p.D166Y|ZNF276_uc010cis.2_Missense_Mutation_p.D139Y|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Missense_Mutation_p.D218Y|ZNF276_uc010cit.1_Missense_Mutation_p.D139Y	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CCAGTCTTCGGACGAGTCCTT	0.547			NA											37	40					5.04308e-16	7.49647e-16	0.025465	1	0
SREBF1	6720	broad.mit.edu	37	17	17720399	17720399	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr17:17720399T>C	uc002gru.1	-	9	1852	c.1658A>G	c.(1657-1659)AAT>AGT	p.N553S	SREBF1_uc002grp.1_Missense_Mutation_p.N172S|SREBF1_uc002grq.1_Missense_Mutation_p.N72S|SREBF1_uc002grr.1_Missense_Mutation_p.N299S|SREBF1_uc002grs.1_Missense_Mutation_p.N529S|SREBF1_uc002grt.1_Missense_Mutation_p.N583S	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	553	Helical; (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CAACAGCCCATTGAGCAGCCA	0.627			NA											37	37					0	0	0.010771	0	0
CBX2	84733	broad.mit.edu	37	17	77758474	77758474	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr17:77758474G>T	uc002jxc.2	+	5	1274	c.1232G>T	c.(1231-1233)AGT>ATT	p.S411I		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	411					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ACAAGCAAAAGTGAGAAGCTG	0.662			NA											6	18					3.59834e-05	3.95817e-05	0.021553	1	0
L3MBTL4	91133	broad.mit.edu	37	18	6241361	6241361	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr18:6241361C>G	uc002kmz.3	-	8	708	c.548G>C	c.(547-549)AGT>ACT	p.S183T	L3MBTL4_uc010dkt.2_Missense_Mutation_p.S183T|L3MBTL4_uc002kmy.3_Missense_Mutation_p.S21T	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	183	MBT 2.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				ACTTACAGGACTTCTGTTTCT	0.289	Esophageal Squamous(41;748 902 17366 28959 43175)		NA											73	128					0	0	0.01441	0	0
DSG3	1830	broad.mit.edu	37	18	29054174	29054174	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr18:29054174C>A	uc002kws.2	+	15	2301	c.2192C>A	c.(2191-2193)TCT>TAT	p.S731Y	DSG3_uc002kwt.2_Missense_Mutation_p.S13Y	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	731	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCCACTGAATCTGGAGGTGCT	0.517			NA											20	37					5.45024e-15	7.99369e-15	0.01892	1	0
B4GALT6	9331	broad.mit.edu	37	18	29206995	29206995	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr18:29206995C>A	uc002kwz.3	-	7	1163	c.866G>T	c.(865-867)GGA>GTA	p.G289V	B4GALT6_uc010dma.2_Missense_Mutation_p.G250V|B4GALT6_uc010dmb.2_Missense_Mutation_p.G250V|B4GALT6_uc002kwy.3_5'Flank	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	289	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			TCCTCCCCATCCCCAGAAGGC	0.338			NA											43	56					1.06522e-23	1.83085e-23	0.013114	1	0
PQLC1	80148	broad.mit.edu	37	18	77679237	77679237	+	Silent	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr18:77679237C>A	uc002lnl.2	-	5	727	c.555G>T	c.(553-555)CTG>CTT	p.L185L	PQLC1_uc010dre.2_Silent_p.L102L|PQLC1_uc002lnk.2_Silent_p.L167L|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	185	PQ-loop 2.|Helical; (Potential).					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		GGGGCACACCCAGCATGGCTT	0.652			NA											13	23					5.50884e-06	6.24713e-06	0.013537	1	0
STK11	6794	broad.mit.edu	37	19	1220448	1220448	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:1220448A>T	uc002lrl.1	+	4	1656	c.541A>T	c.(541-543)AAC>TAC	p.N181Y		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	181	Protein kinase.		N -> E (in sporadic cancer; somatic mutation; impairs heterotrimeric complex assembly with STRADA and CAB39; requires 2 nucleotide substitutions).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.Y156fs*87(4)|p.?(4)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGCCGGGGAACCTGCTGCT	0.662			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			6	1					0	0	0.021553	0	0
HDGFRP2	84717	broad.mit.edu	37	19	4493990	4493990	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:4493990C>T	uc002mao.2	+	8	943	c.850C>T	c.(850-852)CTC>TTC	p.L284F	HDGFRP2_uc002map.2_Missense_Mutation_p.L284F|HDGFRP2_uc010dtz.1_RNA	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	284					transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						GGAGAAGCCTCTCCCGAAGCC	0.701			NA											5	1					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9075084	9075084	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:9075084G>T	uc002mkp.2	-	3	12566	c.12362C>A	c.(12361-12363)ACT>AAT	p.T4121N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4123	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCCAGTGGAGTCCCTGTCCA	0.502			NA											34	12					5.91797e-21	9.57318e-21	0.012213	1	0
OR7E24	26648	broad.mit.edu	37	19	9362240	9362240	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:9362240C>A	uc002mlb.1	+	1	521	c.521C>A	c.(520-522)TCC>TAC	p.S174Y		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	174	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTTTGGACTCCCAGTTGCAC	0.438			NA											14	8					0.00185496	0.00196197	0.016723	1	0
PSG11	5680	broad.mit.edu	37	19	43519460	43519460	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:43519460C>A	uc002ovm.1	-	4	879	c.772G>T	c.(772-774)GAC>TAC	p.D258Y	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Missense_Mutation_p.D264Y|PSG11_uc002ovo.1_Missense_Mutation_p.D136Y|PSG11_uc002ovp.1_Missense_Mutation_p.D136Y	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	258	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CAGGACAAGTCGAGGTTCTCT	0.448			NA											125	86					3.42828e-54	6.5019e-54	0.01441	1	0
CRX	1406	broad.mit.edu	37	19	48339553	48339553	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:48339553G>T	uc002phq.3	+	3	358	c.154G>T	c.(154-156)GAG>TAG	p.E52*	CRX_uc010elm.1_RNA	NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	52	Homeobox.				organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GAGCCAACTGGAGGAGCTGGA	0.627	Pancreas(57;461 1196 22201 40716 47188)		NA											26	9					3.01185e-09	3.72251e-09	0.021523	1	0
ZNF350	59348	broad.mit.edu	37	19	52468837	52468837	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr19:52468837T>C	uc002pyd.2	-	5	1097	c.869A>G	c.(868-870)TAT>TGT	p.Y290C	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	290	C2H2-type 4.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		ACTGCATATATAGGGTTTCTC	0.398			NA											3	95					0	0	0.004672	0	0
PXDN	7837	broad.mit.edu	37	2	1652105	1652105	+	Silent	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:1652105C>T	uc002qxa.2	-	17	3511	c.3447G>A	c.(3445-3447)ACG>ACA	p.T1149T		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1149					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCAGAGCCACCGTGTGTGCCA	0.652			NA											32	53					0	0	0.013726	0	0
APOB	338	broad.mit.edu	37	2	21234296	21234296	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:21234296C>A	uc002red.2	-	26	5572	c.5444G>T	c.(5443-5445)CGG>CTG	p.R1815L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1815					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGGTTCTAGCCGTAGTTTCCC	0.413			NA											83	125					5.71386e-39	1.04754e-38	0.01441	1	0
PLB1	151056	broad.mit.edu	37	2	28748151	28748151	+	Silent	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:28748151G>A	uc002rmb.1	+	5	261	c.261G>A	c.(259-261)ACG>ACA	p.T87T	PLB1_uc010ezj.1_Silent_p.T87T	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	87	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					ACCCAGGGACGGGCGATCTGG	0.353			NA											12	16					0	0	0.020292	0	0
TTC21B	79809	broad.mit.edu	37	2	166747433	166747433	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:166747433G>A	uc002udk.2	-	23	3149	c.3016C>T	c.(3016-3018)CCA>TCA	p.P1006S	TTC21B_uc002udj.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1006						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						AAAAATCTTGGGACATCCTCG	0.348			NA											25	36					0	0	0.01892	0	0
AQP12B	653437	broad.mit.edu	37	2	241621974	241621975	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:241621974_241621975GG>TT	uc010fzj.2	-	1	343_344	c.280_281CC>AA	c.(280-282)CCC>AAC	p.P94N	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	82						integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GGACACGGTGGGGTTGGCCGAG	0.698			NA											23	26					0	0	0.004672	0	0
SNED1	25992	broad.mit.edu	37	2	242009519	242009519	+	Silent	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:242009519G>A	uc002wah.1	+	24	3492	c.3492G>A	c.(3490-3492)CTG>CTA	p.L1164L	SNED1_uc002wai.1_Silent_p.L399L|SNED1_uc002waj.1_Silent_p.L251L|SNED1_uc002wak.2_Silent_p.L251L|SNED1_uc002wal.2_5'Flank	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	1164	Fibronectin type-III 3.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		TGCGCGACCTGCTGCCGGGAC	0.632			NA											11	11					0	0	0.010729	0	0
TTLL9	164395	broad.mit.edu	37	20	30510852	30510852	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr20:30510852A>G	uc010gdx.1	+	8	913	c.660A>G	c.(658-660)ATA>ATG	p.I220M	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.I107M|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	220	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CTTACCTGATAGGAGGTGAGA	0.483			NA											38	37					0	0	0.025465	0	0
SLC13A3	64849	broad.mit.edu	37	20	45221081	45221081	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr20:45221081C>A	uc002xsf.1	-	6	920	c.882G>T	c.(880-882)TGG>TGT	p.W294C	SLC13A3_uc010ghn.1_Missense_Mutation_p.W263C|SLC13A3_uc010zxw.1_Missense_Mutation_p.W244C|SLC13A3_uc002xsg.1_Missense_Mutation_p.W247C|SLC13A3_uc010gho.1_Missense_Mutation_p.W247C|SLC13A3_uc010zxx.1_Missense_Mutation_p.W196C	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	294	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	AGATCCAGAGCCAGCCTGCCA	0.512			NA											14	21					0.000219431	0.000234344	0.020292	1	0
MC3R	4159	broad.mit.edu	37	20	54824041	54824041	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr20:54824041C>A	uc002xxb.2	+	1	254	c.142C>A	c.(142-144)CTG>ATG	p.L48M		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	85	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TTTCCTGTCTCTGGGCATCGT	0.572			NA											40	45					4.67007e-22	7.66727e-22	0.00874	1	0
EEF1A2	1917	broad.mit.edu	37	20	62126186	62126186	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr20:62126186C>A	uc002yfd.1	-	3	694	c.593G>T	c.(592-594)GGT>GTT	p.G198V	EEF1A2_uc002yfe.1_Missense_Mutation_p.G198V|EEF1A2_uc010gkg.1_Missense_Mutation_p.G198V	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	198						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CATGTTGTCACCGTGCCAGCC	0.667			NA											17	16					4.96729e-08	6.00442e-08	0.008871	1	0
ADARB1	104	broad.mit.edu	37	21	46624492	46624492	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr21:46624492G>T	uc002zgy.2	+	10	2143	c.1708G>T	c.(1708-1710)GGA>TGA	p.G570*	ADARB1_uc002zgr.2_Nonsense_Mutation_p.G570*|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Nonsense_Mutation_p.G530*|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Nonsense_Mutation_p.G530*|ADARB1_uc010gpx.2_RNA|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	570	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		GGGCATCCAGGGATCCCTGCT	0.592			NA											32	19					8.88839e-20	1.39675e-19	0.010818	1	0
OXTR	5021	broad.mit.edu	37	3	8809379	8809379	+	Silent	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr3:8809379C>T	uc003brc.2	-	3	1117	c.495G>A	c.(493-495)CTG>CTA	p.L165L		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	165	Helical; Name=4; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CGCTGGCCACCAGGCAGCCGA	0.711			NA											7	1					0	0	0.008291	0	0
MTMR14	64419	broad.mit.edu	37	3	9704014	9704014	+	Silent	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr3:9704014G>T	uc003brz.2	+	3	496	c.372G>T	c.(370-372)CGG>CGT	p.R124R	MTMR14_uc003bsa.2_Silent_p.R124R|MTMR14_uc003bsb.2_Silent_p.R124R|MTMR14_uc011ath.1_Intron|MTMR14_uc010hcl.2_Intron	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	124						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					AGATGGCCCGGTGCAGAGGAC	0.532			NA											18	6					2.35188e-11	2.97364e-11	0.006122	1	0
EPHA3	2042	broad.mit.edu	37	3	89448468	89448468	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr3:89448468C>A	uc003dqy.2	+	7	1657	c.1432C>A	c.(1432-1434)CAG>AAG	p.Q478K	EPHA3_uc003dqx.1_Missense_Mutation_p.Q478K|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	478	Extracellular (Potential).|Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GACCTCAAAGCAGGAACAAGA	0.343			NA								TSP Lung(6;0.00050)			25	10					6.38683e-12	8.36371e-12	0.008361	1	0
SPATA18	132671	broad.mit.edu	37	4	52943040	52943040	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:52943040G>A	uc003gzl.2	+	7	1132	c.854G>A	c.(853-855)AGA>AAA	p.R285K	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.R253K|SPATA18_uc003gzk.1_Missense_Mutation_p.R285K	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	285	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AAGGTCAGGAGACCGTCCCCA	0.667			NA											14	22					0	0	0.020292	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361157	70361157	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:70361157C>A	uc003hek.3	-	1	470	c.423G>T	c.(421-423)CAG>CAT	p.Q141H	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.Q141H	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	141					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ATCTTGACTCCTGTAGTTTCT	0.368			NA											7	15					5.18039e-06	5.93587e-06	0.00308	1	0
FRAS1	80144	broad.mit.edu	37	4	79428721	79428721	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:79428721C>T	uc003hlb.2	+	62	9903	c.9463C>T	c.(9463-9465)CAG>TAG	p.Q3155*	FRAS1_uc003hlc.1_Nonsense_Mutation_p.Q157*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3150	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AATTCTAGACCAGGAGGCAGC	0.512			NA											16	29					0	0	0.00499	0	0
ANK2	287	broad.mit.edu	37	4	114095577	114095577	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:114095577C>A	uc003ibe.3	+	2	190	c.90C>A	c.(88-90)GAC>GAA	p.D30E	ANK2_uc003ibd.3_Missense_Mutation_p.D9E|ANK2_uc003ibf.3_Missense_Mutation_p.D30E|ANK2_uc003ibc.2_Missense_Mutation_p.D6E|ANK2_uc011cgb.1_Missense_Mutation_p.D45E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	30	ANK 1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CGCAGTCTGACAGCAATGCAA	0.403			NA											11	12					3.86212e-05	4.20627e-05	0.008291	1	0
ANK2	287	broad.mit.edu	37	4	114238920	114238920	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:114238920G>T	uc003ibe.3	+	25	2851	c.2751G>T	c.(2749-2751)AGG>AGT	p.R917S	ANK2_uc003ibd.3_Missense_Mutation_p.R896S|ANK2_uc003ibf.3_Missense_Mutation_p.R917S|ANK2_uc011cgc.1_Missense_Mutation_p.R126S|ANK2_uc003ibg.3_5'Flank|ANK2_uc003ibc.2_Missense_Mutation_p.R893S|ANK2_uc011cgb.1_Missense_Mutation_p.R932S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	917					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCTACCTGAGGGACAGTGCCG	0.498			NA											11	24					3.07112e-06	3.55603e-06	0.010729	1	0
SPATA5	166378	broad.mit.edu	37	4	123855380	123855380	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr4:123855380A>T	uc003iez.3	+	5	707	c.634A>T	c.(634-636)ACT>TCT	p.T212S	SPATA5_uc003iey.2_Missense_Mutation_p.T211S	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	212					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TGACTCTGACACTGATGCCCA	0.483			NA											32	48					0	0	0.017118	0	0
TRIO	7204	broad.mit.edu	37	5	14359507	14359507	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:14359507C>T	uc003jff.2	+	13	2264	c.2258C>T	c.(2257-2259)TCC>TTC	p.S753F	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.S704F|TRIO_uc003jfh.1_Missense_Mutation_p.S402F	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	753					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CACAACAGCTCCATCAACCAC	0.547			NA											30	31					0	0	0.012213	0	0
CWC27	10283	broad.mit.edu	37	5	64267586	64267586	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:64267586T>A	uc003jtn.1	+	12	1318	c.1099T>A	c.(1099-1101)TAT>AAT	p.Y367N	CWC27_uc010iwt.1_Missense_Mutation_p.Y367N	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	367	Potential.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						AAAGCAAAAGTATGAAGCTTT	0.373			NA											19	29					0	0	0.014323	0	0
LOC644936	644936	broad.mit.edu	37	5	79596032	79596032	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:79596032T>A	uc010jai.2	-	1	266	c.125A>T	c.(124-126)TAC>TTC	p.Y42F		NR_004845				Homo sapiens cytoplasmic beta-actin pseudogene, mRNA (cDNA clone IMAGE:30378151).												0						GGTGAAGCTGTAGCCACACTG	0.547			NA											4	12					0	0	0.009096	0	0
GPR98	84059	broad.mit.edu	37	5	90020785	90020785	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:90020785G>T	uc003kju.2	+	46	9981	c.9885G>T	c.(9883-9885)CAG>CAT	p.Q3295H	GPR98_uc003kjt.2_Missense_Mutation_p.Q1001H|GPR98_uc003kjv.2_Missense_Mutation_p.Q895H	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3295	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACCGATGGCAGGGGATTTTTA	0.284			NA											15	24					7.93312e-07	9.28344e-07	0.020292	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140723683	140723683	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:140723683C>A	uc003ljm.1	+	1	83	c.83C>A	c.(82-84)TCC>TAC	p.S28Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.S28Y	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACAGGATCCGGTCAGATC	0.587			NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	84	110					1.92282e-43	3.58492e-43	0.01441	1	0
DRD1	1812	broad.mit.edu	37	5	174869091	174869091	+	Silent	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr5:174869091G>T	uc003mcz.2	-	2	1957	c.1012C>A	c.(1012-1014)CGG>AGG	p.R338R		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	338	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	AATGCCTTCCGAAAATCAGCA	0.458			NA											36	66					3.03874e-20	4.84437e-20	0.015359	1	0
HIST1H4J	8363	broad.mit.edu	37	6	27792201	27792201	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr6:27792201G>A	uc003njp.2	+	1	299	c.299G>A	c.(298-300)GGT>GAT	p.G100D	uc003njq.2_5'Flank	NM_021968	NP_068803	P62805	H4_HUMAN	histone cluster 1, H4j	100					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|pancreas(1)	2						ACCCTCTACGGTTTCGGTGGT	0.567			NA											6	23					0	0	0.016723	0	0
KIAA0240	23506	broad.mit.edu	37	6	42797677	42797677	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr6:42797677G>T	uc003osn.1	+	6	1757	c.1606G>T	c.(1606-1608)GGA>TGA	p.G536*	KIAA0240_uc003osm.1_Nonsense_Mutation_p.G536*|KIAA0240_uc011duw.1_Nonsense_Mutation_p.G536*|KIAA0240_uc003oso.1_Nonsense_Mutation_p.G536*|KIAA0240_uc003osp.1_Nonsense_Mutation_p.G536*	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	536										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			AAGCATGTCAGGACCTAGTCG	0.552			NA											39	30					6.97489e-18	1.06561e-17	0.021022	1	0
RUNX2	860	broad.mit.edu	37	6	45480133	45480133	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr6:45480133G>T	uc011dvx.1	+	7	1220	c.1010G>T	c.(1009-1011)AGG>ATG	p.R337M	RUNX2_uc011dvy.1_Missense_Mutation_p.R337M|RUNX2_uc003oxt.2_Missense_Mutation_p.R323M	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	337	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GATGTGCCTAGGCGCATTTCA	0.592			NA											46	38					2.77807e-22	4.63012e-22	0.013114	1	0
TAGAP	117289	broad.mit.edu	37	6	159456981	159456981	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr6:159456981G>T	uc003qrz.2	-	10	2406	c.2074C>A	c.(2074-2076)CTC>ATC	p.L692I	TAGAP_uc011eft.1_Missense_Mutation_p.L629I|TAGAP_uc003qsa.2_Missense_Mutation_p.L514I	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	692					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CTCAGCGGGAGGAGCTCAGGT	0.602			NA											36	39					1.08052e-11	1.38206e-11	0.019004	1	0
ITGB8	3696	broad.mit.edu	37	7	20418673	20418673	+	Splice_Site	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:20418673G>T	uc003suu.2	+	4	1094	c.389_splice	c.e4-1	p.G130_splice	ITGB8_uc011jyh.1_Splice_Site|ITGB8_uc003sut.2_Splice_Site_p.G130_splice	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TATTGAACTAGGAGCCGAAGC	0.328			NA											35	68					1.67305e-13	2.32956e-13	0.025465	1	0
PDE1C	5137	broad.mit.edu	37	7	31877567	31877567	+	Silent	SNP	T	T	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:31877567T>A	uc003tcm.1	-	10	1468	c.999A>T	c.(997-999)GTA>GTT	p.V333V	PDE1C_uc003tcn.1_Silent_p.V333V|PDE1C_uc003tco.1_Silent_p.V393V|PDE1C_uc003tcr.2_Silent_p.V333V|PDE1C_uc003tcs.2_Silent_p.V333V	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	333	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCATTTCAATTACCAAGGTTC	0.408			NA											100	145					0	0	0.01441	0	0
PHKG1	5260	broad.mit.edu	37	7	56149703	56149703	+	Silent	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:56149703G>T	uc003trz.1	-	8	870	c.675C>A	c.(673-675)GCC>GCA	p.A225A	PSPH_uc003trj.2_Intron|PHKG1_uc003try.1_Silent_p.A119A|PHKG1_uc011kdb.1_Silent_p.A257A|PHKG1_uc011kdc.1_Silent_p.A216A|PHKG1_uc011kdd.1_Silent_p.A171A	NM_006213	NP_006204	Q16816	PHKG1_HUMAN	phosphorylase kinase gamma subunit 1	225	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			large_intestine(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCGGGGAGCCGGCCAGCAGCG	0.647	Melanoma(184;580 2064 5329 24177 35303)		NA											12	16					2.80697e-09	3.50872e-09	0.010729	1	0
LOC643955	643955	broad.mit.edu	37	7	62758678	62758678	+	Silent	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:62758678C>A	uc011kdj.1	-	2	200	c.132G>T	c.(130-132)GTG>GTT	p.V44V		NR_003952				Homo sapiens cDNA clone IMAGE:30377995, containing frame-shift errors.												0						TCTCTAACATCACATGTCTAT	0.378			NA											24	142					5.61819e-17	8.46576e-17	0.027356	1	0
PION	54103	broad.mit.edu	37	7	76950085	76950085	+	Silent	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:76950085C>T	uc003ugf.2	-	26	2125	c.2046G>A	c.(2044-2046)AGG>AGA	p.R682R	PION_uc011kgo.1_Silent_p.R3R|PION_uc003ugd.2_Silent_p.R76R	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	682					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CTTCCAGAATCCTGGTCATGA	0.408			NA											16	32					0	0	0.006122	0	0
ZNF789	285989	broad.mit.edu	37	7	99077308	99077308	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:99077308G>T	uc003uqq.1	+	3	268	c.49G>T	c.(49-51)GCG>TCG	p.A17S	ZNF789_uc003uqp.2_Missense_Mutation_p.A17S|ZNF789_uc010lfw.1_5'UTR	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAGGATGTGGCGATGTACTT	0.393			NA											27	44					1.04121e-07	1.24493e-07	0.027356	1	0
VPS13B	157680	broad.mit.edu	37	8	100108540	100108540	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr8:100108540G>T	uc003yiv.2	+	4	403	c.292G>T	c.(292-294)GAT>TAT	p.D98Y	VPS13B_uc003yiw.2_Missense_Mutation_p.D98Y|VPS13B_uc003yit.2_Missense_Mutation_p.D98Y|VPS13B_uc003yiu.1_Missense_Mutation_p.D98Y|VPS13B_uc003yis.2_Missense_Mutation_p.D98Y|VPS13B_uc011lgy.1_5'UTR	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	98					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATAAAAATAGGATGACCATGA	0.358	Colon(161;2205 2542 7338 31318)		NA											28	50					1.06801e-11	1.38206e-11	0.009535	1	0
RNF19A	25897	broad.mit.edu	37	8	101271232	101271232	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr8:101271232C>A	uc003yjj.1	-	11	2386	c.2069G>T	c.(2068-2070)AGA>ATA	p.R690I	RNF19A_uc003yjk.1_Missense_Mutation_p.R690I	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	690	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CATGTCCTCTCTCGTCTCATT	0.423			NA									OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	74	95					1.10782e-18	1.71634e-18	0.01441	1	0
RIMS2	9699	broad.mit.edu	37	8	104928660	104928660	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr8:104928660G>T	uc003yls.2	+	6	1506	c.1265G>T	c.(1264-1266)TGG>TTG	p.W422L	RIMS2_uc003ylp.2_Missense_Mutation_p.W644L|RIMS2_uc003ylw.2_Missense_Mutation_p.W452L|RIMS2_uc003ylq.2_Missense_Mutation_p.W452L|RIMS2_uc003ylr.2_Missense_Mutation_p.W499L|RIMS2_uc003ylt.2_Missense_Mutation_p.W45L|RIMS2_uc003ylu.1_Missense_Mutation_p.W35L|RIMS2_uc003ylv.1_Missense_Mutation_p.W35L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	722	PDZ.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTATTAGAATGGAATGGAAGA	0.353			NA								HNSCC(12;0.0054)			34	45					2.20474e-14	3.19106e-14	0.017118	1	0
PTPRD	5789	broad.mit.edu	37	9	8521415	8521415	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr9:8521415C>T	uc003zkk.2	-	19	1534	c.823G>A	c.(823-825)GAT>AAT	p.D275N	PTPRD_uc003zkp.2_Missense_Mutation_p.D275N|PTPRD_uc003zkq.2_Missense_Mutation_p.D275N|PTPRD_uc003zkr.2_Missense_Mutation_p.D269N|PTPRD_uc003zks.2_Missense_Mutation_p.D265N|PTPRD_uc003zkl.2_Missense_Mutation_p.D275N|PTPRD_uc003zkm.2_Missense_Mutation_p.D262N|PTPRD_uc003zkn.2_Missense_Mutation_p.D275N|PTPRD_uc003zko.2_Missense_Mutation_p.D272N	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	275	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGTGTCAGATCTTCTGCCCCC	0.448			NA								TSP Lung(15;0.13)			28	17					0	0	0.009535	0	0
PTENP1	11191	broad.mit.edu	37	9	33676271	33676271	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr9:33676271C>T	uc003zth.3	-	1	1148	c.277G>A	c.(277-279)GGA>AGA	p.G93R		NR_023917				SubName: Full=Phosphatase and tensin homolog 2; Flags: Fragment;												0						CGTCCCTTTCCAGCTTTACAG	0.398			NA											56	27					0	0	0.01441	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995628	140995628	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chrX:140995628C>T	uc004fbt.2	+	4	2724	c.2438C>T	c.(2437-2439)CCT>CTT	p.P813L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	813							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCAGAGTCCTGTGAGCTCC	0.547			NA								HNSCC(15;0.026)			104	60					0	0	0.01441	0	0
ATP6AP1	537	broad.mit.edu	37	X	153662571	153662571	+	Silent	SNP	C	C	T	rs138051216		TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chrX:153662571C>T	uc004flf.1	+	7	763	c.702C>T	c.(700-702)GCC>GCT	p.A234A	ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Silent_p.A194A|GDI1_uc011mzo.1_5'Flank|GDI1_uc004fli.3_5'Flank	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	234					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGATGTAGCCGTGGTGGCCG	0.582			NA											3	43					0	0	0.004672	0	0
SPATA6	54558	broad.mit.edu	37	1	48764544	48764556	+	Frame_Shift_Del	DEL	GCCACGTGGCTGC	GCCACGTGGCTGC	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	GCCACGTGGCTGC	GCCACGTGGCTGC	-	-	GCCACGTGGCTGC	GCCACGTGGCTGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr1:48764544_48764556delGCCACGTGGCTGC	uc001crr.1	-	13	1461_1473	c.1296_1308delGCAGCCACGTGGC	c.(1294-1308)CAGCAGCCACGTGGCfs	p.Q432fs	SPATA6_uc001crs.1_Frame_Shift_Del_p.Q416fs|SPATA6_uc010omv.1_Frame_Shift_Del_p.Q418fs	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	432_436					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						AATGGAAAGTGCCACGTGGCTGCTGACATGAGC	0.357			NA											23	84	---	---	---	---	NA	NA	NA	NA	NA
MRGPRX1	259249	broad.mit.edu	37	11	18956320	18956320	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr11:18956320delG	uc001mpg.2	-	1	230	c.12delC	c.(10-12)ACCfs	p.T4fs		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	4	Extracellular (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AGGTTGAGATGGTTGGATCCA	0.423			NA											118	191	---	---	---	---	NA	NA	NA	NA	NA
TLK1	9874	broad.mit.edu	37	2	171854326	171854337	+	Splice_Site	DEL	GTAAATACCTGT	GTAAATACCTGT	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	GTAAATACCTGT	GTAAATACCTGT	-	-	GTAAATACCTGT	GTAAATACCTGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr2:171854326_171854337delGTAAATACCTGT	uc002ugn.2	-	19	2377	c.1905_splice	c.e19-1	p.W635_splice	TLK1_uc002ugo.2_Splice_Site_p.W656_splice|TLK1_uc002ugp.2_Splice_Site_p.W587_splice|TLK1_uc002ugq.2_Splice_Site|TLK1_uc010zdn.1_Splice_Site_p.W539_splice	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1						cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						CACTCAGGAGGTAAATACCTGTAAGTTTTGTG	0.344			NA											50	121	---	---	---	---	NA	NA	NA	NA	NA
ZBED4	9889	broad.mit.edu	37	22	50277679	50277679	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr22:50277679delT	uc003bix.2	+	2	839	c.369delT	c.(367-369)CATfs	p.H123fs		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	123	BED-type 1.					cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CCTGGAAGCATTTTTTTATCT	0.512			NA											21	15	---	---	---	---	NA	NA	NA	NA	NA
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chr7:44684936delT	uc003tln.2	+	3	342	c.233delT	c.(232-234)ATTfs	p.I78fs	OGDH_uc003tlm.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbx.1_Frame_Shift_Del_p.I78fs|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kbz.1_5'UTR|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577			NA											7	195	---	---	---	---	NA	NA	NA	NA	NA
CAPN6	827	broad.mit.edu	37	X	110494814	110494824	+	Frame_Shift_Del	DEL	AGGGGTTTCTC	AGGGGTTTCTC	-			TCGA-50-5932-01A-11D-1753-08	TCGA-50-5932-11A-01D-1753-08	AGGGGTTTCTC	AGGGGTTTCTC	-	-	AGGGGTTTCTC	AGGGGTTTCTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6726c157-f688-491d-8b56-35628645df89	5c91a9d6-124c-4ffe-acf5-ce43a4c2c742	g.chrX:110494814_110494824delAGGGGTTTCTC	uc004epc.1	-	6	1014_1024	c.846_856delGAGAAACCCCT	c.(844-858)CTGAGAAACCCCTTGfs	p.L282fs	CAPN6_uc011msu.1_Frame_Shift_Del_p.L27fs	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	282_286	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						TGTCTTCCCAAGGGGTTTCTCAGGCGAACCA	0.488			NA											51	246	---	---	---	---	NA	NA	NA	NA	NA
