Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTLL10	254173	broad.mit.edu	37	1	1117798	1117798	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:1117798G>C	uc001acy.2	+	10	1039	c.888G>C	c.(886-888)GAG>GAC	p.E296D	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.E296D|TTLL10_uc001acz.1_Missense_Mutation_p.E223D	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	296	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCAAACACGAGAGAGAGGCCT	0.443			NA											7	81					0	0	0.000157383	0	0
SPEN	23013	broad.mit.edu	37	1	16256410	16256410	+	Silent	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:16256410C>T	uc001axk.1	+	11	3879	c.3675C>T	c.(3673-3675)AGC>AGT	p.S1225S	SPEN_uc010obp.1_Silent_p.S1184S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1225					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTCCTCCTAGCAAAAAGAAAA	0.438			NA											8	61					0	0	0.000274275	0	0
ZNF362	149076	broad.mit.edu	37	1	33745793	33745793	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:33745793A>T	uc001bxc.1	+	5	588	c.418A>T	c.(418-420)ACG>TCG	p.T140S		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGGCACGGGCACGGGTACCAG	0.697	Pancreas(162;1431 2676 35353 38425)		NA											5	79					0	0	0.000602214	0	0
LRRC41	10489	broad.mit.edu	37	1	46746150	46746150	+	Silent	SNP	C	C	A	rs141700475	by1000genomes	TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:46746150C>A	uc001cpn.2	-	6	1883	c.1839G>T	c.(1837-1839)TCG>TCT	p.S613S	LRRC41_uc010omb.1_Silent_p.S613S	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	613	LRR 4.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GCAGAGAACCCGAGGCCTTCA	0.562			NA											16	83					3.45872e-05	0.000446987	0.000422831	1	0
CLCA1	1179	broad.mit.edu	37	1	86951204	86951204	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:86951204G>C	uc001dlt.2	+	6	1043	c.914G>C	c.(913-915)AGA>ACA	p.R305T	CLCA1_uc001dls.1_Missense_Mutation_p.R244T	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	305					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		ATTGGACAAAGAATTGTGTGT	0.453			NA											4	81					0	0	0.00024832	0	0
COL11A1	1301	broad.mit.edu	37	1	103468337	103468337	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:103468337C>G	uc001dul.2	-	22	2327	c.2009G>C	c.(2008-2010)GGT>GCT	p.G670A	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G682A|COL11A1_uc001dun.2_Missense_Mutation_p.G631A|COL11A1_uc009weh.2_Missense_Mutation_p.G554A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	670	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCCATCTACACCTGCCATACC	0.323			NA											3	25					0	0	6.4e-05	0	0
SV2A	9900	broad.mit.edu	37	1	149884837	149884837	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:149884837C>A	uc001etg.2	-	2	1047	c.556G>T	c.(556-558)GTG>TTG	p.V186L	SV2A_uc001eth.2_Missense_Mutation_p.V186L	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	186	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACGAAGCCCACCACAAAGACC	0.582			NA											17	76					8.00594e-06	0.000108195	0.000958276	1	0
MCL1	4170	broad.mit.edu	37	1	150550957	150550957	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:150550957C>G	uc001euz.2	-	2	829	c.699G>C	c.(697-699)CGG>CGC	p.R233R	MCL1_uc010pch.1_Silent_p.R123R|MCL1_uc001eva.2_Intron	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	233					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGTCCAGTTTCCGAAGCATGC	0.522			NA											4	77					0	0	3.59834e-05	0	0
FLG2	388698	broad.mit.edu	37	1	152323904	152323904	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:152323904T>A	uc001ezw.3	-	3	6431	c.6358A>T	c.(6358-6360)ACA>TCA	p.T2120S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2120							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGAATGTGTGTGTGAGACC	0.527			NA											71	353					0	0	0.000781405	0	0
KPRP	448834	broad.mit.edu	37	1	152732194	152732194	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:152732194C>A	uc001fal.1	+	2	188	c.130C>A	c.(130-132)CAA>AAA	p.Q44K		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	44	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTGAGATGCAAATTGTGGA	0.567			NA											21	89					1.10923e-09	1.67091e-08	0.000375601	1	0
C1orf77	26097	broad.mit.edu	37	1	153615717	153615717	+	Silent	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:153615717C>A	uc001fcm.1	+	5	730	c.418C>A	c.(418-420)CGA>AGA	p.R140R	C1orf77_uc001fcn.1_Silent_p.R141R|C1orf77_uc001fco.1_Silent_p.R115R|C1orf77_uc001fcp.2_5'Flank|C1orf77_uc009woj.1_3'UTR	NM_015607	NP_056422	Q9Y3Y2	CHTOP_HUMAN	small protein rich in arginine and glycine	140	Arg/Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	protein binding|RNA binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAACCTGCTCCGAGGTGGACG	0.537			NA											7	145					0.000274275	0.003414	0.000274275	1	0
TMEM79	84283	broad.mit.edu	37	1	156255160	156255160	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:156255160G>C	uc010phi.1	+	2	339	c.143G>C	c.(142-144)AGA>ACA	p.R48T	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Intron|TMEM79_uc009wrw.2_Missense_Mutation_p.R48T	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	48						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					GAGTCCCTCAGAGTGGGGTCT	0.627			NA											5	52					0	0	0.000602214	0	0
PEAR1	375033	broad.mit.edu	37	1	156873742	156873742	+	Silent	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:156873742C>A	uc001fqj.1	+	2	140	c.24C>A	c.(22-24)CTC>CTA	p.L8L	PEAR1_uc009wsl.1_5'Flank|PEAR1_uc001fqk.1_5'Flank	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	8						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGTGTCCCCTCCTTCTCCTGG	0.642			NA											14	84					2.23348e-06	3.07104e-05	0.000422831	1	0
FCRL5	83416	broad.mit.edu	37	1	157494111	157494111	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:157494111G>C	uc001fqu.2	-	10	2355	c.2197C>G	c.(2197-2199)CTG>GTG	p.L733V	FCRL5_uc009wsm.2_Missense_Mutation_p.L733V|FCRL5_uc010phv.1_Missense_Mutation_p.L733V|FCRL5_uc010phw.1_Missense_Mutation_p.L648V	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	733	Extracellular (Potential).|Ig-like C2-type 7.			L -> P (in Ref. 1; AAK50059).		integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGGGCCTCCAGACCATTGTCT	0.567			NA											12	59					0	0	0.000978159	0	0
UBE2T	29089	broad.mit.edu	37	1	202301085	202301085	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:202301085C>T	uc001gxx.3	-	7	608	c.472G>A	c.(472-474)GAT>AAT	p.D158N		NM_014176	NP_054895	Q9NPD8	UBE2T_HUMAN	ubiquitin-conjugating enzyme E2T	158					DNA repair|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	nucleoplasm	ATP binding|ubiquitin-protein ligase activity				0						TCTTCCTCATCAGCCTAAAGA	0.423			NA											6	79					0	0	8.12818e-05	0	0
SLC45A3	85414	broad.mit.edu	37	1	205633646	205633646	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:205633646C>A	uc001hda.1	-	2	478	c.139G>T	c.(139-141)GGG>TGG	p.G47W	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_5'Flank|SLC45A3_uc010prp.1_RNA|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	47					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TCCTCTACCCCCACTTCCAGC	0.567			NA	T	ETV1|ETV5|ELK4|ERG	prostate 								25	129					1.77063e-15	2.7917e-14	0.000878237	1	0
GPATCH2	55105	broad.mit.edu	37	1	217671721	217671721	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:217671721C>A	uc001hlf.1	-	7	1279	c.1183G>T	c.(1183-1185)GGG>TGG	p.G395W	GPATCH2_uc009xdq.1_RNA	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	395						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		GTCCTAGCCCCAGGGCTAAAC	0.463			NA											15	123					3.35478e-16	5.32486e-15	0.000308642	1	0
ENAH	55740	broad.mit.edu	37	1	225706984	225706984	+	Missense_Mutation	SNP	G	G	A	rs142024814		TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:225706984G>A	uc001hpc.1	-	5	1171	c.718C>T	c.(718-720)CGG>TGG	p.R240W	ENAH_uc001hpd.1_Missense_Mutation_p.R240W	NM_001008493	NP_001008493	Q8N8S7	ENAH_HUMAN	enabled homolog isoform a	240	Potential.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding	p.R240W(1)		ovary(1)|skin(1)	2	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		TGCCTCTCCCGTTCCAGTCTC	0.393			NA											19	294					0	0	0.000132079	0	0
PYCR2	29920	broad.mit.edu	37	1	226109657	226109657	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:226109657C>A	uc001hpq.2	-	4	596	c.441G>T	c.(439-441)CAG>CAT	p.Q147H	LEFTY1_uc010pvj.1_Intron|PYCR2_uc001hpp.2_Missense_Mutation_p.Q111H|PYCR2_uc001hpr.2_Missense_Mutation_p.Q100H|PYCR2_uc001hps.1_Missense_Mutation_p.Q100H	NM_013328	NP_037460	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member	147					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity				0	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	GCTCCAGGAGCTGCCCATCCT	0.627			NA											5	25					1.23904e-05	0.000161897	0.000602214	1	0
OBSCN	84033	broad.mit.edu	37	1	228466415	228466415	+	Silent	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:228466415G>T	uc009xez.1	+	26	6929	c.6885G>T	c.(6883-6885)CCG>CCT	p.P2295P	OBSCN_uc001hsn.2_Silent_p.P2295P|OBSCN_uc001hsp.1_5'UTR|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2295	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCGTGCGCCCGCTGCGGGACA	0.667			NA											8	45					2.27111e-07	3.21627e-06	0.00010058	1	0
OR2M2	391194	broad.mit.edu	37	1	248343825	248343825	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:248343825G>T	uc010pzf.1	+	1	538	c.538G>T	c.(538-540)GAA>TAA	p.E180*		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTTCTTCTGTGAATTCCCTTC	0.423			NA											15	127					2.23348e-06	3.07104e-05	0.000422831	1	0
OR2T2	401992	broad.mit.edu	37	1	248616145	248616145	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:248616145C>A	uc001iek.1	+	1	47	c.47C>A	c.(46-48)ACA>AAA	p.T16K		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCGTCCTCACAGGCCTCATC	0.502			NA											14	132					1.02788e-11	1.58885e-10	0.000566183	1	0
TACC2	10579	broad.mit.edu	37	10	123843455	123843455	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr10:123843455G>T	uc001lfv.2	+	4	1800	c.1440G>T	c.(1438-1440)GAG>GAT	p.E480D	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.E480D|TACC2_uc010qtv.1_Missense_Mutation_p.E480D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	480						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCAAGGGAGAGCATCCAGAAG	0.587			NA											18	84					8.81451e-21	1.42783e-19	0.000132079	1	0
RHOG	391	broad.mit.edu	37	11	3849357	3849357	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:3849357G>C	uc001lyu.2	-	2	170	c.12C>G	c.(10-12)ATC>ATG	p.I4M		NM_001665	NP_001656	P84095	RHOG_HUMAN	ras homolog gene family, member G precursor	4					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		CCACGCACTTGATGCTCTGCA	0.577			NA											4	19					0	0	0.00024832	0	0
SYT9	143425	broad.mit.edu	37	11	7437318	7437318	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:7437318C>G	uc001mfe.2	+	4	1327	c.1090C>G	c.(1090-1092)CCA>GCA	p.P364A	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	364	Cytoplasmic (Potential).|C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GTGCTATCTTCCAACGGCTGG	0.443			NA											7	111					0	0	8.12818e-05	0	0
GALNTL4	374378	broad.mit.edu	37	11	11643072	11643072	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:11643072G>A	uc001mjo.2	-	1	490	c.69C>T	c.(67-69)ATC>ATT	p.I23I		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	23	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		GCAGGCAGATGATGTTAGTCA	0.577			NA											5	24					0	0	0.000602214	0	0
SYT13	57586	broad.mit.edu	37	11	45275886	45275886	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:45275886G>T	uc001myq.2	-	3	605	c.479C>A	c.(478-480)CCC>CAC	p.P160H	SYT13_uc009yku.1_Missense_Mutation_p.P16H	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	160	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						GTGGAGTTTGGGGGCCTGGTT	0.522			NA											7	38					1.06961e-07	1.54246e-06	0.000157383	1	0
OR5A1	219982	broad.mit.edu	37	11	59210711	59210712	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:59210711_59210712CC>AA	uc001nnx.1	+	1	70_71	c.70_71CC>AA	c.(70-72)CCA>AAA	p.P24K		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CACAGACCATCCAGAACTCCAG	0.53			NA											15	66					0	0	6.4e-05	0	0
OR4D6	219983	broad.mit.edu	37	11	59224585	59224585	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:59224585G>C	uc010rku.1	+	1	152	c.152G>C	c.(151-153)TGT>TCT	p.C51S		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACTATTACCTGTGAGTCCCGC	0.473			NA											18	71					0	0	0.000958276	0	0
CD6	923	broad.mit.edu	37	11	60781476	60781476	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:60781476C>G	uc001nqq.2	+	8	1600	c.1377C>G	c.(1375-1377)ATC>ATG	p.I459M	CD6_uc001nqp.2_Missense_Mutation_p.I459M|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.I459M	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	459	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CCATCACCATCCCCAAAGAAG	0.602	Pancreas(169;904 2017 4767 38890 42505)		NA											3	30					0	0	0.00024832	0	0
DAK	26007	broad.mit.edu	37	11	61105499	61105499	+	Silent	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:61105499C>T	uc001nre.2	+	3	347	c.90C>T	c.(88-90)CTC>CTT	p.L30L	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_5'UTR	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	30	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						ACCTGCAGCTCCTGCAGGGCC	0.667			NA											8	97					0	0	0.000274275	0	0
Unknown	0	broad.mit.edu	37	11	89768527	89768527	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:89768527G>C	uc010rua.1	+	2	271	c.148G>C	c.(148-150)GTC>CTC	p.V50L		NM_020358	NP_065091			ring finger protein 18												NA						CCCATTTCTTGTCCAGTGCTC	0.458			NA											12	56					0	0	0.000219431	0	0
CEP57	9702	broad.mit.edu	37	11	95532445	95532445	+	Missense_Mutation	SNP	C	C	T	rs139110744	byFrequency	TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:95532445C>T	uc001pfp.1	+	2	316	c.95C>T	c.(94-96)TCT>TTT	p.S32F	CEP57_uc001pfo.1_Missense_Mutation_p.S32F|CEP57_uc010ruh.1_Missense_Mutation_p.S23F|CEP57_uc010rui.1_Missense_Mutation_p.S32F|CEP57_uc009ywn.1_5'UTR|CEP57_uc001pfq.1_Missense_Mutation_p.S32F|CEP57_uc001pfr.1_5'UTR	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	32					fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTTCGGCATTCTTCATCTCCA	0.408			NA							Mosaic_Variegated_Aneuploidy_Syndrome				5	68					0	0	0.000602214	0	0
BACE1	23621	broad.mit.edu	37	11	117186290	117186290	+	Silent	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:117186290G>C	uc001pqz.2	-	1	683	c.222C>G	c.(220-222)GGC>GGG	p.G74G	BACE1_uc001pqw.2_Silent_p.G74G|BACE1_uc001pqx.2_Silent_p.G74G|BACE1_uc001pqy.2_Silent_p.G74G|BACE1_uc001pra.1_Silent_p.G74G	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	74	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		CCACGTAGTAGCCCTGCCCCG	0.682			NA											4	29					0	0	3.59834e-05	0	0
SORL1	6653	broad.mit.edu	37	11	121461839	121461839	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr11:121461839C>G	uc001pxx.2	+	31	4423	c.4343C>G	c.(4342-4344)TCT>TGT	p.S1448C	SORL1_uc010rzp.1_Missense_Mutation_p.S294C|SORL1_uc010rzq.1_Missense_Mutation_p.S63C	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1448	Extracellular (Potential).|LDL-receptor class A 9.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCAGATGGCTCTGACGAGGAA	0.617			NA									OREG0021431	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	85					0	0	8.12818e-05	0	0
FOXM1	2305	broad.mit.edu	37	12	2977809	2977809	+	Missense_Mutation	SNP	G	G	C	rs137928577		TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:2977809G>C	uc001qlf.2	-	4	1031	c.766C>G	c.(766-768)CGC>GGC	p.R256G	FOXM1_uc001qle.2_Missense_Mutation_p.R256G|FOXM1_uc001qlg.2_Missense_Mutation_p.R256G|FOXM1_uc009zea.2_Missense_Mutation_p.R255G|FOXM1_uc009zeb.2_Missense_Mutation_p.R255G	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	256	Fork-head.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			AAAGTCATGCGCTTCCTCTCA	0.502			NA											20	115					0	0	0.000175454	0	0
USP5	8078	broad.mit.edu	37	12	6973060	6973060	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:6973060G>A	uc001qri.3	+	16	2080	c.2021G>A	c.(2020-2022)CGC>CAC	p.R674H	USP5_uc001qrh.3_Missense_Mutation_p.R651H	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	674	UBA 1.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						GACGCCTGCCGCAAAGCTGTC	0.587			NA											12	28					0	0	0.000219431	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46320526	46320526	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:46320526C>G	uc001rox.2	-	11	3245	c.2958G>C	c.(2956-2958)AAG>AAC	p.K986N	SFRS2IP_uc001row.2_Missense_Mutation_p.K671N|SFRS2IP_uc001roy.1_Missense_Mutation_p.K1060N	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	986					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CTGGGTCATTCTTTCTGTACC	0.398			NA											15	144					0	0	0.000308642	0	0
SCYL2	55681	broad.mit.edu	37	12	100691891	100691891	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:100691891A>G	uc001thn.2	+	4	468	c.418A>G	c.(418-420)ATA>GTA	p.I140V	SCYL2_uc009ztw.1_5'UTR|SCYL2_uc001thm.1_Missense_Mutation_p.I140V	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	140	Protein kinase.			PISPDIK -> LMSGDIG (in Ref. 4; BAA92598).	endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						ACCTTCCCCTATATCTCCAGA	0.323			NA											10	29					0	0	0.000151284	0	0
CUX2	23316	broad.mit.edu	37	12	111779685	111779685	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:111779685C>A	uc001tsa.1	+	21	3640	c.3487C>A	c.(3487-3489)CTG>ATG	p.L1163M		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1163						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCCCCAGGACCTGAGCCTCCT	0.657			NA											8	36					0.000274275	0.003414	0.000274275	1	0
RFC3	5983	broad.mit.edu	37	13	34399957	34399957	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr13:34399957C>G	uc001uuz.2	+	4	435	c.325C>G	c.(325-327)CAG>GAG	p.Q109E	RFC3_uc001uva.2_Missense_Mutation_p.Q109E|RFC3_uc010ted.1_Missense_Mutation_p.Q109E	NM_002915	NP_002906	P40938	RFC3_HUMAN	replication factor C 3 isoform 1	109					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding				0		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		AGTAGTCATTCAGGAGATGTT	0.333			NA											4	26					0	0	0.00024832	0	0
CCNA1	8900	broad.mit.edu	37	13	37015312	37015312	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr13:37015312C>G	uc001uvr.3	+	7	1506	c.1156C>G	c.(1156-1158)CTG>GTG	p.L386V	CCNA1_uc010teo.1_Missense_Mutation_p.L342V|CCNA1_uc010abq.2_Missense_Mutation_p.L342V|CCNA1_uc010abp.2_Missense_Mutation_p.L342V|CCNA1_uc001uvs.3_Missense_Mutation_p.L385V|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	386					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TCTTCCTTCACTGATAGCTGC	0.383			NA											3	50					0	0	0.000602214	0	0
OR11G2	390439	broad.mit.edu	37	14	20666236	20666236	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:20666236C>T	uc010tlb.1	+	1	742	c.742C>T	c.(742-744)CTC>TTC	p.L248F		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	248	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGTCTTTATGCTCTTTCTCTT	0.498			NA											29	191					0	0	0.000339439	0	0
TTC5	91875	broad.mit.edu	37	14	20763529	20763529	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:20763529C>A	uc001vwt.2	-	8	1057	c.1000G>T	c.(1000-1002)GGT>TGT	p.G334C	TTC5_uc001vwu.2_Missense_Mutation_p.G191C	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	334					DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		ATGACGGCACCGCTGTTCACC	0.532			NA											9	38					0.000442599	0.00539561	0.000442599	1	0
FLJ10357	55701	broad.mit.edu	37	14	21542190	21542190	+	Missense_Mutation	SNP	C	C	T	rs148208165	byFrequency	TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:21542190C>T	uc001vzp.2	+	3	330	c.301C>T	c.(301-303)CGC>TGC	p.R101C	FLJ10357_uc001vzn.1_Missense_Mutation_p.R101C|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	101					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GCAACTGCTGCGCCCAGGAGA	0.632			NA											10	99					0	0	0.000673444	0	0
DLGAP5	9787	broad.mit.edu	37	14	55621352	55621352	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:55621352C>G	uc001xbs.2	-	15	2263	c.2046G>C	c.(2044-2046)TTG>TTC	p.L682F	DLGAP5_uc001xbt.2_Missense_Mutation_p.L682F	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	682					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CAGGAATACTCAAAAACAAAG	0.358			NA											3	93					0	0	0.00024832	0	0
KIAA0586	9786	broad.mit.edu	37	14	58932631	58932631	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:58932631A>C	uc001xdv.3	+	14	2183	c.1910A>C	c.(1909-1911)CAT>CCT	p.H637P	KIAA0586_uc010trr.1_Missense_Mutation_p.H754P|KIAA0586_uc001xdt.3_Missense_Mutation_p.H669P|KIAA0586_uc001xdu.3_Missense_Mutation_p.H698P|KIAA0586_uc010trs.1_Missense_Mutation_p.H628P|KIAA0586_uc010trt.1_Missense_Mutation_p.H573P|KIAA0586_uc010tru.1_Missense_Mutation_p.H573P	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	637										ovary(1)	1						AAAATGAAACATTCTGTTCCT	0.383			NA											25	105					0	0	0.000586117	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72055435	72055435	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:72055435C>G	uc001xms.2	+	2	1194	c.846C>G	c.(844-846)CTC>CTG	p.L282L	SIPA1L1_uc001xmt.2_Silent_p.L282L|SIPA1L1_uc001xmu.2_Silent_p.L282L|SIPA1L1_uc001xmv.2_Silent_p.L282L	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	282					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAAAACCACTCAAGCGACGTT	0.433			NA											5	47					0	0	0.000602214	0	0
SEL1L	6400	broad.mit.edu	37	14	81964260	81964260	+	Silent	SNP	A	A	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:81964260A>G	uc010tvv.1	-	10	1221	c.1104T>C	c.(1102-1104)GCT>GCC	p.A368A		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	368	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		CACCTTTTTCAGCTAGGAACT	0.408			NA											3	44					0	0	6.4e-05	0	0
TRIP11	9321	broad.mit.edu	37	14	92491704	92491704	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:92491704G>C	uc001xzy.2	-	3	1050	c.262C>G	c.(262-264)CAA>GAA	p.Q88E		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	88	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TGCTTTATTTGAATCTCTGAT	0.303	Ovarian(84;609 1888 9852 42686)		NA	T	PDGFRB	AML								3	67					0	0	0.00024832	0	0
PAPOLA	10914	broad.mit.edu	37	14	96993794	96993794	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr14:96993794C>T	uc001yfq.2	+	5	569	c.359C>T	c.(358-360)GCA>GTA	p.A120V	PAPOLA_uc001yfo.2_Missense_Mutation_p.A120V|PAPOLA_uc001yfp.2_Missense_Mutation_p.A120V|PAPOLA_uc001yfr.2_Missense_Mutation_p.A120V|PAPOLA_uc010twv.1_Missense_Mutation_p.A120V|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	120					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TTGTGTGTTGCACCAAGACAT	0.338	NSCLC(19;254 734 11908 35501 39234)		NA											7	54					0	0	0.000274275	0	0
C15orf55	256646	broad.mit.edu	37	15	34640781	34640781	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr15:34640781G>A	uc001zif.2	+	2	783	c.628G>A	c.(628-630)GTT>ATT	p.V210I	C15orf55_uc010ucc.1_Missense_Mutation_p.V238I|C15orf55_uc010ucd.1_Missense_Mutation_p.V228I	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	210						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TTCCAAGGACGTTTATGAGAA	0.532			NA	T	BRD3|BRD4	lethal midline carcinoma								6	53					0	0	8.12818e-05	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43653495	43653495	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr15:43653495C>A	uc001zrk.1	-	5	2482	c.2335G>T	c.(2335-2337)GCA>TCA	p.A779S	ZSCAN29_uc001zrj.1_Missense_Mutation_p.A659S|ZSCAN29_uc010bdf.1_3'UTR|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Missense_Mutation_p.A389S	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	779	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTCCGATGTGCACTAAAATGA	0.448			NA											8	82					1.12685e-05	0.000148883	0.000274275	1	0
IQCH	64799	broad.mit.edu	37	15	67553673	67553673	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr15:67553673G>T	uc002aqo.1	+	2	162	c.115G>T	c.(115-117)GAG>TAG	p.E39*	IQCH_uc010ujv.1_5'UTR|IQCH_uc002aqn.1_5'UTR|IQCH_uc002aqq.1_5'UTR|IQCH_uc002aqp.1_5'UTR|IQCH_uc002aqm.2_Nonsense_Mutation_p.E39*	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	39										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		GGAAAAAGGAGAGACTCTAGA	0.328			NA											8	117					0.000442599	0.00539561	0.000442599	1	0
GLYR1	84656	broad.mit.edu	37	16	4861235	4861235	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:4861235C>T	uc002cxx.3	-	15	1560	c.1523G>A	c.(1522-1524)CGC>CAC	p.R508H	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.R422H|GLYR1_uc002cya.2_Missense_Mutation_p.R502H|GLYR1_uc010uxv.1_Missense_Mutation_p.R427H	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	508					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						AATGGCTAAGCGGAGATCCTT	0.507			NA											9	128					0	0	0.000442599	0	0
CLEC16A	23274	broad.mit.edu	37	16	11114107	11114107	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:11114107C>T	uc002dao.2	+	12	1591	c.1361C>T	c.(1360-1362)TCC>TTC	p.S454F	CLEC16A_uc002dan.3_Missense_Mutation_p.S436F	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	454								p.0?(1)		ovary(1)|central_nervous_system(1)	2						GCCAGCACCTCCGTGCAGGAG	0.592			NA											6	33					0	0	3.59834e-05	0	0
CP110	9738	broad.mit.edu	37	16	19548753	19548753	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:19548753C>G	uc002dgl.3	+	4	2009	c.1762C>G	c.(1762-1764)CTT>GTT	p.L588V	CP110_uc002dgk.3_Missense_Mutation_p.L588V			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	588				RRL->ARA: Abolishes interaction with CCNF.	centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TAAACGGAGACTTGATTTAGA	0.363			NA											5	111					0	0	0.000602214	0	0
CACNG3	10368	broad.mit.edu	37	16	24268164	24268164	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:24268164C>A	uc002dmf.2	+	1	1289	c.89C>A	c.(88-90)ACG>AAG	p.T30K		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	30					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GCAGTGGGCACGGACTACTGG	0.448			NA											25	119					7.38237e-10	1.11919e-08	0.00106085	1	0
ITGAD	3681	broad.mit.edu	37	16	31419778	31419778	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:31419778C>G	uc002ebv.1	+	10	1091	c.1042C>G	c.(1042-1044)CAC>GAC	p.H348D	ITGAD_uc010vfl.1_3'UTR|ITGAD_uc010cap.1_Missense_Mutation_p.H348D|ITGAD_uc002ebw.1_3'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	348	Extracellular (Potential).|FG-GAP 3.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CTCCTTCCAGCACGAGATGTC	0.453			NA											3	33					0	0	6.4e-05	0	0
TP53	7157	broad.mit.edu	37	17	7578499	7578499	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:7578499T>A	uc002gim.2	-	5	625	c.431A>T	c.(430-432)CAG>CTG	p.Q144L	TP53_uc002gig.1_Missense_Mutation_p.Q144L|TP53_uc002gih.2_Missense_Mutation_p.Q144L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q12L|TP53_uc010cng.1_Missense_Mutation_p.Q12L|TP53_uc002gii.1_Missense_Mutation_p.Q12L|TP53_uc010cnh.1_Missense_Mutation_p.Q144L|TP53_uc010cni.1_Missense_Mutation_p.Q144L|TP53_uc002gij.2_Missense_Mutation_p.Q144L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q51L|TP53_uc002gio.2_Missense_Mutation_p.Q12L|TP53_uc010vug.1_Missense_Mutation_p.Q105L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	144	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(29)|p.Q144L(8)|p.0?(7)|p.Q144H(4)|p.Q144P(4)|p.Q144R(4)|p.Q144fs*26(3)|p.Q144K(2)|p.Q144del(2)|p.Q144Q(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.Q144fs*4(1)|p.P142_Q144delPVQ(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACCCACAGCTGCACAGGGCA	0.597	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	38					0	0	0.000442599	0	0
KIAA0100	9703	broad.mit.edu	37	17	26961982	26961982	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:26961982C>T	uc002hbu.2	-	16	2722	c.2623G>A	c.(2623-2625)GAG>AAG	p.E875K		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	875						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GAGAAGTGCTCAACCTTTAAG	0.473			NA											14	280					0	0	0.000219431	0	0
TAOK1	57551	broad.mit.edu	37	17	27849370	27849370	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:27849370G>C	uc002hdz.1	+	17	2175	c.1981G>C	c.(1981-1983)GAA>CAA	p.E661Q	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Missense_Mutation_p.E661Q	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	661					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			ATCTATGCAAGAACTGGAGTT	0.418			NA											6	61					0	0	8.12818e-05	0	0
KRTAP9-4	85280	broad.mit.edu	37	17	39405983	39405983	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:39405983G>T	uc002hwi.2	+	1	45	c.11G>T	c.(10-12)TGT>TTT	p.C4F	KRTAP9-9_uc010wfq.1_Intron	NM_033191	NP_149461	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	4						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			ATGACCCACTGTTGCTCCCCT	0.577			NA											14	105					1.67942e-08	2.45174e-07	0.00074312	1	0
IMP5	162540	broad.mit.edu	37	17	43922672	43922672	+	Missense_Mutation	SNP	C	C	G	rs140064060	byFrequency	TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:43922672C>G	uc010wka.1	+	1	400	c.400C>G	c.(400-402)CTG>GTG	p.L134V	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	134	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		AGACACCACCCTGGCACCCCA	0.637	NSCLC(24;34 1393 18470)		NA											4	25					0	0	0.00024832	0	0
PRR11	55771	broad.mit.edu	37	17	57278969	57278969	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:57278969A>T	uc002ixf.1	+	10	1139	c.1060A>T	c.(1060-1062)AGC>TGC	p.S354C	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	354										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					ACTTTCTACAAGCAGCTTTGA	0.343			NA											16	61					0	0	0.00074312	0	0
CBX4	8535	broad.mit.edu	37	17	77808599	77808599	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:77808599G>C	uc002jxe.2	-	5	1005	c.842C>G	c.(841-843)TCC>TGC	p.S281C		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	281	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACCTCGCCGGACTTGATCTT	0.582			NA									OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	193					0	0	0.000157383	0	0
EPB41L3	23136	broad.mit.edu	37	18	5398126	5398127	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr18:5398126_5398127CC>AA	uc002kmt.1	-	17	2451_2452	c.2365_2366GG>TT	c.(2365-2367)GGG>TTG	p.G789L	EPB41L3_uc010wzh.1_Missense_Mutation_p.G620L|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Missense_Mutation_p.G94L|EPB41L3_uc010wzf.1_Missense_Mutation_p.G86L|EPB41L3_uc010wzg.1_Missense_Mutation_p.G61L|EPB41L3_uc010dkr.2_Missense_Mutation_p.G181L	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	789	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GAGCTTTTCCCCAGAAGACTGC	0.426			NA											11	265					0	0	6.4e-05	0	0
MCART2	147407	broad.mit.edu	37	18	29340372	29340372	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr18:29340372G>C	uc002kxa.2	-	1	472	c.253C>G	c.(253-255)CTT>GTT	p.L85V		NM_001034172	NP_001029344	Q3SY17	MCAR2_HUMAN	mitochondrial carrier triple repeat 2	85	Solcar 1.|Helical; Name=2; (Potential).				transport	integral to membrane|mitochondrial inner membrane				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0539)			AATGGGGGAAGGATTCCACGA	0.473			NA											7	74					0	0	8.12818e-05	0	0
SLC14A2	8170	broad.mit.edu	37	18	43249420	43249420	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr18:43249420C>T	uc010dnj.2	+	17	2507	c.2186C>T	c.(2185-2187)TCC>TTC	p.S729F	SLC14A2_uc002lbe.2_Missense_Mutation_p.S729F	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	729						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CAGCCTGCATCCGCCATGCCC	0.547			NA											11	95					0	0	0.000978159	0	0
ADNP2	22850	broad.mit.edu	37	18	77895022	77895022	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr18:77895022C>G	uc002lnw.2	+	4	2181	c.1726C>G	c.(1726-1728)CTG>GTG	p.L576V		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	576					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CACCAACATTCTGCCTGTGAA	0.547			NA											10	74					0	0	0.000673444	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2405397	2405397	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:2405397G>A	uc010xgx.1	+	6	594	c.594G>A	c.(592-594)AGG>AGA	p.R198R	TMPRSS9_uc002lvv.1_Silent_p.R232R	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	198	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCTGGAGGATGGCCGGCA	0.627			NA											8	58					0	0	0.000274275	0	0
APBA3	9546	broad.mit.edu	37	19	3760138	3760138	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:3760138C>A	uc002lyp.1	-	2	302	c.125G>T	c.(124-126)GGA>GTA	p.G42V	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	42					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGGGGCCTCCTGGCATAGG	0.632			NA											14	57					9.16793e-09	1.35513e-07	0.000566183	1	0
FFAR3	2865	broad.mit.edu	37	19	35850463	35850463	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:35850463C>T	uc002nzd.2	+	2	746	c.671C>T	c.(670-672)GCG>GTG	p.A224V	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	224	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			AGGAGGGTGGCGGGGCTGTTG	0.642	Esophageal Squamous(185;1742 2042 21963 24215 27871)		NA											9	89					0	0	0.000274275	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316653	40316653	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:40316653G>A	uc002omj.2	-	11	1872	c.1592C>T	c.(1591-1593)TCT>TTT	p.S531F	DYRK1B_uc002omi.2_Missense_Mutation_p.S503F|DYRK1B_uc002omk.2_Missense_Mutation_p.S491F	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	531					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			TGACGAGGCAGAGGCAGGGGC	0.657			NA											17	27					0	0	0.00074312	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42396885	42396885	+	Silent	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:42396885G>T	uc002orx.2	+	7	688	c.579G>T	c.(577-579)GTG>GTT	p.V193V	ARHGEF1_uc002orw.1_Silent_p.V193V|ARHGEF1_uc002ory.2_Silent_p.V160V|ARHGEF1_uc002orz.2_Silent_p.V31V|ARHGEF1_uc002osa.2_Silent_p.V208V|ARHGEF1_uc002osb.2_Silent_p.V175V|ARHGEF1_uc002osc.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	193	RGSL.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		AGCGGCACGTGGCGGAGCGGC	0.701			NA											5	6					0.000602214	0.00722963	0.000602214	1	0
PSG1	5669	broad.mit.edu	37	19	43382154	43382155	+	Missense_Mutation	DNP	CG	CG	AT	rs142473373		TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:43382154_43382155CG>AT	uc002ovb.2	-	2	478_479	c.340_341CG>AT	c.(340-342)CGG>ATG	p.R114M	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.R114M|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.R114M|PSG1_uc010eio.1_Missense_Mutation_p.R114M|PSG1_uc002oux.1_Missense_Mutation_p.R43M|PSG1_uc002ouy.1_Missense_Mutation_p.R114M|PSG1_uc002ouz.1_Missense_Mutation_p.R114M|PSG1_uc002ova.1_Missense_Mutation_p.R114M|PSG1_uc002ovc.2_Missense_Mutation_p.R114M|PSG1_uc002ovd.1_Missense_Mutation_p.R114M	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	114	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGCGTCCTCCCGGGTGACATTC	0.45			NA											11	497					0	0	6.4e-05	0	0
PSG6	5675	broad.mit.edu	37	19	43421914	43421914	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:43421914G>T	uc002ovj.1	-	1	83	c.31C>A	c.(31-33)CAG>AAG	p.Q11K	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Missense_Mutation_p.Q11K|PSG6_uc002ovg.1_Missense_Mutation_p.Q11K	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	11					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GTGATGTGCTGAGTGCAGGGA	0.597			NA											51	104					6.3091e-27	1.02904e-25	0.000781405	1	0
SYNGR4	23546	broad.mit.edu	37	19	48869140	48869140	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr19:48869140A>C	uc002piz.2	+	2	286	c.41A>C	c.(40-42)GAA>GCA	p.E14A	TMEM143_uc002piw.1_5'Flank|TMEM143_uc002pix.1_5'Flank|TMEM143_uc002piy.1_5'Flank|TMEM143_uc010xzn.1_5'Flank|TMEM143_uc010elw.1_5'Flank|TMEM143_uc010xzo.1_5'Flank|TMEM143_uc010xzp.1_5'Flank|TMEM143_uc010xzq.1_5'Flank	NM_012451	NP_036583	O95473	SNG4_HUMAN	synaptogyrin 4	14						integral to membrane					0		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		GCCAACAGCGAAGCCGTGCAG	0.647			NA											3	81					0	0	6.4e-05	0	0
CAD	790	broad.mit.edu	37	2	27449776	27449776	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:27449776C>T	uc002rji.2	+	15	2395	c.2233C>T	c.(2233-2235)CTT>TTT	p.L745F	CAD_uc010eyw.2_Missense_Mutation_p.L682F	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	745	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TCGATGGGACCTTAGCAAGTT	0.577			NA											19	111					0	0	0.000132079	0	0
AAK1	22848	broad.mit.edu	37	2	69736403	69736403	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:69736403G>A	uc002sfp.2	-	14	2471	c.1966C>T	c.(1966-1968)CTC>TTC	p.L656F	AAK1_uc010fdk.2_Missense_Mutation_p.L656F|AAK1_uc010yqm.1_Missense_Mutation_p.L657F	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	656						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						GCTGCCTGGAGCAGCTGGGTT	0.552			NA											6	87					0	0	0.000157383	0	0
MPHOSPH10	10199	broad.mit.edu	37	2	71365639	71365639	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:71365639C>G	uc002sht.1	+	5	1470	c.1118C>G	c.(1117-1119)TCT>TGT	p.S373C	MPHOSPH10_uc010feb.1_Missense_Mutation_p.S373C	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	373	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AAAATTGCATCTTTAGAAAAA	0.338			NA											3	25					0	0	0.000602214	0	0
ZNF638	27332	broad.mit.edu	37	2	71653619	71653619	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:71653619A>C	uc002shx.2	+	24	4939	c.4620A>C	c.(4618-4620)GAA>GAC	p.E1540D	ZNF638_uc002shy.2_Missense_Mutation_p.E1540D|ZNF638_uc002shz.2_Missense_Mutation_p.E1540D|ZNF638_uc002sia.2_Missense_Mutation_p.E1540D|ZNF638_uc002sib.1_Missense_Mutation_p.N1132T|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.E637D|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1540					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATTTGGATGAATTTGTTACTG	0.343			NA											9	68					0	0	0.000151284	0	0
ZNF638	27332	broad.mit.edu	37	2	71653631	71653631	+	Silent	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:71653631G>T	uc002shx.2	+	24	4951	c.4632G>T	c.(4630-4632)GTG>GTT	p.V1544V	ZNF638_uc002shy.2_Silent_p.V1544V|ZNF638_uc002shz.2_Silent_p.V1544V|ZNF638_uc002sia.2_Silent_p.V1544V|ZNF638_uc002sib.1_Missense_Mutation_p.W1136L|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Silent_p.V641V|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1544					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TTGTTACTGTGGATGAGGTTA	0.348			NA											9	70					6.42651e-13	1.00654e-11	0.000978159	1	0
LCT	3938	broad.mit.edu	37	2	136558235	136558235	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:136558235G>C	uc002tuu.1	-	12	4819	c.4808C>G	c.(4807-4809)GCT>GGT	p.A1603G		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1603	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCTGGGTTCAGCCCAGTCACT	0.517			NA											16	57					0	0	0.00074312	0	0
LCT	3938	broad.mit.edu	37	2	136570244	136570244	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:136570244G>T	uc002tuu.1	-	7	2001	c.1990C>A	c.(1990-1992)CCC>ACC	p.P664T		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	664	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTGAACTCGGGGAGTTGAGCC	0.557			NA											12	71					6.31663e-08	9.16492e-07	0.000308642	1	0
KYNU	8942	broad.mit.edu	37	2	143799696	143799696	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:143799696C>G	uc002tvl.2	+	14	1483	c.1353C>G	c.(1351-1353)ACC>ACG	p.T451T	KYNU_uc010fnm.2_Silent_p.T451T	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	451					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ataaaTTTACCAATCTGCTCA	0.284			NA											3	30					0	0	6.4e-05	0	0
ACVR1	90	broad.mit.edu	37	2	158622640	158622640	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:158622640C>T	uc002tzm.3	-	9	1198	c.859G>A	c.(859-861)GAA>AAA	p.E287K	ACVR1_uc002tzn.3_Missense_Mutation_p.E287K|ACVR1_uc010fog.2_Missense_Mutation_p.E287K	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	287	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	GATCCCATTTCATGATAATGT	0.403			NA											8	71					0	0	0.000157383	0	0
TTN	7273	broad.mit.edu	37	2	179613587	179613587	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:179613587C>A	uc002unb.2	-	46	13764	c.13540G>T	c.(13540-13542)GCA>TCA	p.A4514S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTCTCTGCCTGATACATA	0.323			NA											6	44					8.12818e-05	0.00104474	8.12818e-05	1	0
ORC2L	4999	broad.mit.edu	37	2	201822819	201822819	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:201822819T>A	uc002uwr.2	-	3	285	c.28A>T	c.(28-30)AAG>TAG	p.K10*	ORC2L_uc010zhj.1_Nonsense_Mutation_p.K10*	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	10					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						TCCAGCATCTTGTCTTCCTTT	0.343			NA											6	63					0	0	8.12818e-05	0	0
ADAM23	8745	broad.mit.edu	37	2	207426992	207426992	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:207426992A>T	uc002vbq.2	+	13	1543	c.1320A>T	c.(1318-1320)CAA>CAT	p.Q440H	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	440	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TTGGAATCCAATGGGAACCTT	0.413	Melanoma(194;1127 2130 19620 24042 27855)		NA											41	138					0	0	0.000374591	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217303159	217303159	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:217303159T>A	uc002vgc.3	+	10	1991	c.1661T>A	c.(1660-1662)CTC>CAC	p.L554H	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.L554H|SMARCAL1_uc010fvg.2_Intron	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	554	Helicase ATP-binding.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		TCTCACTTCCTCAAAAACAGT	0.468			NA							Schimke_Immuno-Osseous_Dysplasia				6	25					0	0	0.000442599	0	0
SAG	6295	broad.mit.edu	37	2	234238166	234238166	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:234238166G>T	uc002vuh.2	+	9	1064	c.676G>T	c.(676-678)GTG>TTG	p.V226L	SAG_uc010zmq.1_Missense_Mutation_p.V92L	NM_000541	NP_000532	P10523	ARRS_HUMAN	S-arrestin	226					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			ovary(1)	1		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		GCCCATCCCTGTGACCGTGAC	0.443			NA											12	30					0.000151284	0.00192359	0.000151284	1	0
PASK	23178	broad.mit.edu	37	2	242047654	242047654	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:242047654C>G	uc002wao.1	-	16	3687	c.3595G>C	c.(3595-3597)GAG>CAG	p.E1199Q	PASK_uc010zol.1_Missense_Mutation_p.E1013Q|PASK_uc010zom.1_Missense_Mutation_p.E1164Q|PASK_uc010fzl.1_Missense_Mutation_p.E1206Q|PASK_uc010zon.1_Missense_Mutation_p.E980Q	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1199	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GGGTTCTCCTCAAAGACCAGC	0.597			NA											6	68					0	0	8.12818e-05	0	0
HDLBP	3069	broad.mit.edu	37	2	242203865	242203865	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:242203865G>A	uc002waz.2	-	4	460	c.232C>T	c.(232-234)CAG>TAG	p.Q78*	HDLBP_uc002wba.2_Nonsense_Mutation_p.Q78*|HDLBP_uc002wbb.2_Nonsense_Mutation_p.Q99*|HDLBP_uc010fzn.1_5'UTR|uc010zoo.1_5'Flank	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	78					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GTTTCTACCTGAGTGATGACA	0.358			NA											25	85					0	0	0.00047179	0	0
PLCB1	23236	broad.mit.edu	37	20	8628584	8628584	+	Missense_Mutation	SNP	C	C	A	rs142186851		TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr20:8628584C>A	uc002wnb.2	+	6	505	c.502C>A	c.(502-504)CGT>AGT	p.R168S	PLCB1_uc010zrb.1_Missense_Mutation_p.R67S|PLCB1_uc010gbv.1_Missense_Mutation_p.R168S|PLCB1_uc002wmz.1_Missense_Mutation_p.R168S|PLCB1_uc002wna.2_Missense_Mutation_p.R168S|PLCB1_uc002wnc.1_Missense_Mutation_p.R67S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	168					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TCCAGAAGGGCGTATTCCTCT	0.323			NA											9	55					2.80697e-09	4.17515e-08	0.000978159	1	0
PLCB4	5332	broad.mit.edu	37	20	9319651	9319651	+	Silent	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr20:9319651C>A	uc002wnf.2	+	6	472	c.336C>A	c.(334-336)ACC>ACA	p.T112T	PLCB4_uc010gbw.1_Silent_p.T112T|PLCB4_uc010gbx.2_Silent_p.T112T|PLCB4_uc002wne.2_Silent_p.T112T	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	112					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTAGTTTTACCTACATGGTGG	0.408			NA											5	29					0.000602214	0.00722963	0.000602214	1	0
SEL1L2	80343	broad.mit.edu	37	20	13868493	13868493	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr20:13868493A>C	uc010gcf.2	-	8	749	c.667T>G	c.(667-669)TAC>GAC	p.Y223D	SEL1L2_uc002woq.3_Missense_Mutation_p.Y84D|SEL1L2_uc010zrl.1_Missense_Mutation_p.Y223D|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	223	Sel1-like 4.|Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						AAATATCTGTACCCCTAAAAC	0.313			NA											7	155					0	0	0.000157383	0	0
ITCH	83737	broad.mit.edu	37	20	33026420	33026420	+	Silent	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr20:33026420C>T	uc010geu.1	+	9	978	c.786C>T	c.(784-786)CCC>CCT	p.P262P	ITCH_uc002xak.2_Silent_p.P221P|ITCH_uc010zuj.1_Silent_p.P111P	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	262	Arg/Pro-rich (PRR domain).				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						CACCACCACCCACCCCACGTA	0.438			NA											8	83					0	0	0.000274275	0	0
CTCFL	140690	broad.mit.edu	37	20	56089661	56089661	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr20:56089661C>G	uc010gix.1	-	6	1979	c.1317G>C	c.(1315-1317)CGG>CGC	p.R439R	CTCFL_uc010giw.1_Silent_p.R439R|CTCFL_uc002xym.2_Silent_p.R439R|CTCFL_uc010giz.1_Silent_p.R27R|CTCFL_uc010giy.1_Silent_p.R109R|CTCFL_uc010gja.1_Intron|CTCFL_uc010gjb.1_Silent_p.R439R|CTCFL_uc010gjc.1_Silent_p.R439R|CTCFL_uc010gjd.1_Silent_p.R439R|CTCFL_uc010gje.2_Silent_p.R439R|CTCFL_uc010gjf.2_Silent_p.R234R|CTCFL_uc010gjg.2_Silent_p.R171R|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Silent_p.R234R|CTCFL_uc010gjj.1_Silent_p.R439R	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	439	C2H2-type 7.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GGTCGCTTTTCCGTGCAATGA	0.488			NA									OREG0026065	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	178					0	0	0.00074312	0	0
DYRK1A	1859	broad.mit.edu	37	21	38853104	38853104	+	Missense_Mutation	SNP	G	G	T	rs1049775		TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr21:38853104G>T	uc002ywk.2	+	4	567	c.492G>T	c.(490-492)TTG>TTT	p.L164F	DYRK1A_uc002ywh.1_Missense_Mutation_p.L126F|DYRK1A_uc002ywi.2_Missense_Mutation_p.L164F|DYRK1A_uc002ywj.2_Missense_Mutation_p.L155F|DYRK1A_uc002ywl.2_Missense_Mutation_p.L164F|DYRK1A_uc002ywm.2_Missense_Mutation_p.L164F	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	164	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						TTGACTCCTTGATAGGCAAAG	0.348	Melanoma(114;464 1602 31203 43785 45765)		NA											10	66					1.61879e-10	2.46996e-09	0.00010058	1	0
ITGB2	3689	broad.mit.edu	37	21	46314930	46314930	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr21:46314930C>G	uc002zgd.2	-	8	1083	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	ITGB2_uc002zge.2_Missense_Mutation_p.E347Q|ITGB2_uc002zgf.3_Missense_Mutation_p.E347Q|ITGB2_uc011afl.1_Missense_Mutation_p.E269Q|ITGB2_uc010gpw.2_Missense_Mutation_p.E290Q|ITGB2_uc002zgg.2_Missense_Mutation_p.E347Q	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	347	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CTGGAGTCCTCAGACAGCTCC	0.572			NA											4	58					0	0	3.59834e-05	0	0
TOM1	10043	broad.mit.edu	37	22	35719782	35719782	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr22:35719782C>T	uc003ann.2	+	6	648	c.523C>T	c.(523-525)CAA>TAA	p.Q175*	TOM1_uc011ami.1_Nonsense_Mutation_p.Q142*|TOM1_uc011amj.1_Nonsense_Mutation_p.Q18*|TOM1_uc003ans.2_Nonsense_Mutation_p.Q18*|TOM1_uc011amk.1_Nonsense_Mutation_p.Q137*|TOM1_uc003anp.2_Nonsense_Mutation_p.Q175*|TOM1_uc011aml.1_Nonsense_Mutation_p.Q130*|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Nonsense_Mutation_p.Q169*|TOM1_uc003anr.2_Nonsense_Mutation_p.Q18*	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	175					endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CTCAGAGACACAATCAGGACA	0.597			NA											10	54					0	0	0.000673444	0	0
FOXRED2	80020	broad.mit.edu	37	22	36886232	36886232	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr22:36886232C>G	uc003apn.3	-	8	1986	c.1878G>C	c.(1876-1878)GTG>GTC	p.V626V	FOXRED2_uc003apm.3_Silent_p.V178V|FOXRED2_uc003apo.3_Silent_p.V626V|FOXRED2_uc003app.3_Silent_p.V626V	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	626					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						TCTCGGTACTCACGAGTCCCT	0.612			NA											11	135					0	0	0.000673444	0	0
TRMU	55687	broad.mit.edu	37	22	46752863	46752863	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr22:46752863A>G	uc003bhp.2	+	11	1590	c.1226A>G	c.(1225-1227)GAC>GGC	p.D409G	TRMU_uc003bhq.2_Missense_Mutation_p.D191G|TRMU_uc003bhs.2_3'UTR|TRMU_uc003bhr.2_Missense_Mutation_p.D295G|TRMU_uc003bht.2_Missense_Mutation_p.D262G|TRMU_uc003bhu.2_Missense_Mutation_p.D191G|TRMU_uc003bhv.2_3'UTR	NM_018006	NP_060476	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate	409						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			ovary(1)	1		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		AGCCCCAGTGACAGCCCAGAA	0.642			NA											3	32					0	0	6.4e-05	0	0
CNTN4	152330	broad.mit.edu	37	3	3067833	3067833	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:3067833G>C	uc003bpc.2	+	14	1755	c.1534G>C	c.(1534-1536)GGA>CGA	p.G512R	CNTN4_uc003bpb.1_Missense_Mutation_p.G184R|CNTN4_uc003bpd.1_Missense_Mutation_p.G512R|CNTN4_uc003bpe.2_Missense_Mutation_p.G184R|CNTN4_uc003bpf.2_Missense_Mutation_p.G184R	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	512	Ig-like C2-type 6.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGTCACTGTTGGAGAGAGTAT	0.418			NA											3	26					0	0	6.4e-05	0	0
PLCL2	23228	broad.mit.edu	37	3	17053011	17053011	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:17053011G>T	uc011awc.1	+	5	2254	c.2149G>T	c.(2149-2151)GGC>TGC	p.G717C	PLCL2_uc011awd.1_Missense_Mutation_p.G599C	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	725	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CGGAAACTGTGGCTATGTCCT	0.488			NA											12	45					9.31168e-06	0.000125126	0.000151284	1	0
CNOT10	25904	broad.mit.edu	37	3	32754764	32754764	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:32754764A>G	uc003cfc.1	+	5	731	c.476A>G	c.(475-477)TAT>TGT	p.Y159C	CNOT10_uc011axi.1_Intron|CNOT10_uc003cfd.1_Missense_Mutation_p.Y158C|CNOT10_uc003cfe.1_Missense_Mutation_p.Y159C|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Missense_Mutation_p.Y219C|CNOT10_uc010hfw.1_5'UTR	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	159					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						GTAGACCTGTATATATTAACC	0.353			NA											6	58					0	0	3.59834e-05	0	0
NISCH	11188	broad.mit.edu	37	3	52526236	52526236	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:52526236G>T	uc011beg.1	+	22	4325	c.4253G>T	c.(4252-4254)CGA>CTA	p.R1418L	NISCH_uc003ded.3_Missense_Mutation_p.R1418L|NISCH_uc003dee.3_Missense_Mutation_p.R907L|NISCH_uc003deg.1_Intron|NISCH_uc003deh.3_Missense_Mutation_p.R167L	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1418					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GACCTGGACCGAGTGCTCATG	0.632			NA											20	79					4.54149e-19	7.25717e-18	0.000295444	1	0
PRICKLE2	166336	broad.mit.edu	37	3	64084971	64084971	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:64084971C>G	uc003dmf.2	-	8	2877	c.2291G>C	c.(2290-2292)CGC>CCC	p.R764P		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	764						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GGGTCCCCAGCGGTCCCCAAA	0.597			NA											4	29					0	0	0.00024832	0	0
ROBO2	6092	broad.mit.edu	37	3	77542452	77542452	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:77542452T>C	uc003dpy.3	+	5	1368	c.725T>C	c.(724-726)GTA>GCA	p.V242A	ROBO2_uc003dpz.2_Missense_Mutation_p.V242A|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V242A	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	242	Ig-like C2-type 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GAAGAAGCTGTAGAATTTCGT	0.408			NA											3	37					0	0	0.00024832	0	0
C3orf26	84319	broad.mit.edu	37	3	99895214	99895214	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:99895214G>C	uc003dtl.2	+	9	854	c.711G>C	c.(709-711)TGG>TGC	p.W237C		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	237							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						TTTTTGACTGGAACTGGAGAG	0.403			NA											3	46					0	0	6.4e-05	0	0
CBLB	868	broad.mit.edu	37	3	105459348	105459348	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:105459348T>C	uc003dwc.2	-	7	1295	c.973A>G	c.(973-975)AGG>GGG	p.R325G	CBLB_uc011bhi.1_Missense_Mutation_p.R347G|CBLB_uc003dwd.1_Missense_Mutation_p.R325G|CBLB_uc003dwe.1_Missense_Mutation_p.R325G|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	325	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AATCCTTCCCTGCTGCCATCA	0.418	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								17	70					0	0	0.000132079	0	0
GTPBP8	29083	broad.mit.edu	37	3	112710081	112710081	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:112710081G>C	uc003dzn.2	+	1	282	c.235G>C	c.(235-237)GCC>CCC	p.A79P	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.A79P	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	79					barrier septum formation		GTP binding				0						GGAGGACATAGCCAGGGCGGA	0.632			NA											6	43					0	0	3.59834e-05	0	0
FSTL1	11167	broad.mit.edu	37	3	120134836	120134836	+	Silent	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:120134836C>A	uc003eds.2	-	3	277	c.102G>T	c.(100-102)GTG>GTT	p.V34V	FSTL1_uc011bjh.1_Intron|FSTL1_uc010hrb.2_Silent_p.V34V	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	34	Follistatin-like.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		CTCCACAAAACACATTGGCAC	0.498			NA											6	106					1.12685e-05	0.000148883	0.000274275	1	0
KCNAB1	7881	broad.mit.edu	37	3	156175289	156175289	+	Silent	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:156175289C>G	uc003far.2	+	4	469	c.405C>G	c.(403-405)CTC>CTG	p.L135L	KCNAB1_uc011bon.1_Silent_p.L135L|KCNAB1_uc003fas.2_Silent_p.L124L|KCNAB1_uc003fat.2_Silent_p.L117L|KCNAB1_uc010hvt.1_Silent_p.L117L|KCNAB1_uc011boo.1_Silent_p.L11L	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	135						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GTGTTAACCTCTTTGATACTG	0.468			NA											14	102					0	0	0.000566183	0	0
SENP5	205564	broad.mit.edu	37	3	196630482	196630482	+	Splice_Site	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr3:196630482G>A	uc003fwz.3	+	6	2133	c.1884_splice	c.e6+1	p.K628_splice	SENP5_uc011bty.1_Splice_Site_p.K628_splice	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5						cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		GACTAAAAAGGTATTCTCTTT	0.328	Ovarian(47;891 1095 11174 13858 51271)		NA											6	53					0	0	8.12818e-05	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401343	11401343	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr4:11401343T>A	uc003gmq.2	-	2	610	c.287A>T	c.(286-288)TAC>TTC	p.Y96F		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	96						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						GCCGTGGCTGTAATGCTCCTC	0.647			NA											16	66					0	0	0.00074312	0	0
TEC	7006	broad.mit.edu	37	4	48178124	48178124	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr4:48178124G>T	uc003gxz.2	-	3	309	c.218C>A	c.(217-219)CCC>CAC	p.P73H		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	73	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ATTTTGACAGGGAATGACACC	0.373			NA											22	109					1.64113e-05	0.000213257	0.000175454	1	0
KIAA0922	23240	broad.mit.edu	37	4	154547372	154547372	+	Silent	SNP	T	T	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr4:154547372T>C	uc003inm.3	+	30	4168	c.4116T>C	c.(4114-4116)AAT>AAC	p.N1372N	KIAA0922_uc010ipp.2_Silent_p.N1373N|KIAA0922_uc010ipq.2_Silent_p.N1141N	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1372	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				ACATCTGCAATCCCATGTAAG	0.343			NA											3	49					0	0	0.000602214	0	0
FNIP2	57600	broad.mit.edu	37	4	159772518	159772518	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr4:159772518C>G	uc003iqe.3	+	8	956	c.773C>G	c.(772-774)TCC>TGC	p.S258C		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	258	Ser-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TCTCCAAGCTCCTCTACATCT	0.448			NA											39	359					0	0	0.000509022	0	0
IRX1	79192	broad.mit.edu	37	5	3600760	3600760	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:3600760G>T	uc003jde.2	+	3	1402	c.1350G>T	c.(1348-1350)CAG>CAT	p.Q450H		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	450						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGCCGGCACAGCAGTTAAAGT	0.627			NA											9	64					1.33987e-11	2.05766e-10	0.000673444	1	0
AMACR	23600	broad.mit.edu	37	5	33989575	33989575	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:33989575G>C	uc003jig.2	-	5	854	c.772C>G	c.(772-774)CAG>GAG	p.Q258E	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.Q243E|AMACR_uc003jij.2_Missense_Mutation_p.Q258E	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	258					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						ATGCTCATCTGATTGGGAAGT	0.368			NA											3	52					0	0	6.4e-05	0	0
OXCT1	5019	broad.mit.edu	37	5	41862832	41862832	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:41862832G>A	uc003jmn.2	-	2	430	c.99C>T	c.(97-99)TCC>TCT	p.S33S		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	33					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	GAGCACTGGTGGAAAAGGAAC	0.368			NA											9	73					0	0	0.000442599	0	0
GPR98	84059	broad.mit.edu	37	5	90124896	90124896	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:90124896G>T	uc003kju.2	+	77	16600	c.16504G>T	c.(16504-16506)GTG>TTG	p.V5502L	GPR98_uc003kjt.2_Missense_Mutation_p.V3208L|GPR98_uc003kjw.2_Missense_Mutation_p.V1163L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5502	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTATTTTTCTGTGGGTTCTCG	0.438			NA											6	74					5.9392e-07	8.36084e-06	3.59834e-05	1	0
PCDHGB4	8641	broad.mit.edu	37	5	140769504	140769504	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:140769504G>C	uc003lkc.1	+	1	2053	c.2053G>C	c.(2053-2055)GAG>CAG	p.E685Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.E685Q	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	685	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCAGGCTGAGCTGCAGTT	0.617			NA											8	130					0	0	0.000274275	0	0
NHP2	55651	broad.mit.edu	37	5	177580545	177580545	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr5:177580545C>G	uc003mir.2	-	2	320	c.177G>C	c.(175-177)CAG>CAC	p.Q59H	NHP2_uc003mis.2_Missense_Mutation_p.Q59H	NM_017838	NP_060308	Q9NX24	NHP2_HUMAN	nucleolar protein family A, member 2 isoform a	59					rRNA pseudouridine synthesis	Cajal body|nucleolus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding				0						CGCGCCGAATCTGCTTCTGCT	0.572			NA											10	125					0	0	0.000673444	0	0
F13A1	2162	broad.mit.edu	37	6	6182302	6182302	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:6182302G>T	uc003mwv.2	-	11	1501	c.1378C>A	c.(1378-1380)CAC>AAC	p.H460N	F13A1_uc011dib.1_Missense_Mutation_p.H397N	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	460					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTCCCAATGTGGGTGGCATCC	0.413			NA											11	51					0.000151284	0.00192359	0.000151284	1	0
PPP1R10	5514	broad.mit.edu	37	6	30570127	30570127	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:30570127G>T	uc003nqn.1	-	19	2851	c.2299C>A	c.(2299-2301)CAT>AAT	p.H767N	PPP1R10_uc010jsc.1_Missense_Mutation_p.H421N	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	767	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TGGGGACGATGTCCACTGCTG	0.672			NA											16	109					4.14922e-12	6.45585e-11	0.000422831	1	0
GUCA1A	2978	broad.mit.edu	37	6	42146104	42146104	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:42146104C>G	uc003orx.2	+	4	933	c.288C>G	c.(286-288)TTC>TTG	p.F96L	GUCA1A_uc011duo.1_RNA|GUCA1A_uc010jxt.2_Missense_Mutation_p.F96L	NM_000409	NP_000400	P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	96	EF-hand 3.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity				0	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCTGGTACTTCAAGCTCTATG	0.607			NA											10	85					0	0	0.000442599	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90578514	90578514	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:90578514G>C	uc003pnr.2	+	8	5701	c.5505G>C	c.(5503-5505)AAG>AAC	p.K1835N	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.K1835N|CASP8AP2_uc011dzz.1_Missense_Mutation_p.K1835N	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1835	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCACAAAAAGAGAAGAAACA	0.343	Colon(187;1656 2025 17045 31481 39901)		NA											3	23					0	0	6.4e-05	0	0
AIM1	202	broad.mit.edu	37	6	106968959	106968959	+	Silent	SNP	G	G	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:106968959G>T	uc003prh.2	+	2	3139	c.2652G>T	c.(2650-2652)CCG>CCT	p.P884P		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	884							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGGGTGCCCCGCCCTGTGGTT	0.473			NA											13	84					2.27111e-07	3.21627e-06	0.00010058	1	0
COL10A1	1300	broad.mit.edu	37	6	116442718	116442718	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:116442718C>G	uc003pwm.2	-	3	657	c.561G>C	c.(559-561)CAG>CAC	p.Q187H	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	187	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		TTTCCCCTTTCTGTCCATTCA	0.602			NA											5	35					0	0	0.000602214	0	0
NCOA7	135112	broad.mit.edu	37	6	126249891	126249891	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:126249891G>C	uc010kes.2	+	18	3252	c.2803G>C	c.(2803-2805)GAT>CAT	p.D935H	NCOA7_uc003qae.3_Missense_Mutation_p.D935H|NCOA7_uc003qah.2_Missense_Mutation_p.D924H|NCOA7_uc003qai.2_Missense_Mutation_p.D935H|NCOA7_uc010ket.2_Missense_Mutation_p.D820H|NCOA7_uc003qak.2_Missense_Mutation_p.D212H	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	935	TLD.				cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CATAGTTCAGGATCTGGAGGT	0.398			NA											8	86					0	0	0.000274275	0	0
REPS1	85021	broad.mit.edu	37	6	139251120	139251120	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:139251120G>A	uc003qii.2	-	9	1830	c.1251C>T	c.(1249-1251)AGC>AGT	p.S417S	REPS1_uc003qig.3_Silent_p.S417S|REPS1_uc011edr.1_Silent_p.S417S|REPS1_uc003qij.2_Silent_p.S417S|REPS1_uc003qik.2_Silent_p.S50S	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	417						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TAACCTCACTGCTCTGATTCA	0.448			NA											8	59					0	0	0.000157383	0	0
SHPRH	257218	broad.mit.edu	37	6	146276124	146276124	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr6:146276124C>A	uc003qlf.2	-	2	734	c.335G>T	c.(334-336)TGG>TTG	p.W112L	SHPRH_uc003qld.2_Missense_Mutation_p.W112L|SHPRH_uc003qle.2_Missense_Mutation_p.W112L|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Intron|SHPRH_uc003qlk.1_Missense_Mutation_p.W112L	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	112					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AAATGCTTTCCAGGAATTATC	0.328			NA											8	27					1.12685e-05	0.000148883	0.000274275	1	0
IGF2BP3	10643	broad.mit.edu	37	7	23401202	23401202	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:23401202C>T	uc003swg.2	-	5	618	c.352G>A	c.(352-354)GAA>AAA	p.E118K		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	118	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						ACTGCAGTTTCCGAGTCAGTG	0.338			NA											10	181					0	0	0.000673444	0	0
PKD1L1	168507	broad.mit.edu	37	7	47897302	47897302	+	Silent	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:47897302C>A	uc003tny.1	-	28	4491	c.4491G>T	c.(4489-4491)GGG>GGT	p.G1497G		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1497	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CAGGACTGTGCCCAGCAAGGT	0.562			NA											17	70					0.000566183	0.00686679	0.000566183	1	0
PKD1L1	168507	broad.mit.edu	37	7	47968881	47968882	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:47968881_47968882CC>AA	uc003tny.1	-	7	979_980	c.979_980GG>TT	c.(979-981)GGG>TTG	p.G327L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	327	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGAACTGTCCCCGAAATCCATC	0.51			NA											8	235					0	0	6.4e-05	0	0
MEPCE	56257	broad.mit.edu	37	7	100030679	100030679	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:100030679C>G	uc003uuw.2	+	2	1922	c.1809C>G	c.(1807-1809)ATC>ATG	p.I603M	MEPCE_uc003uuv.2_Missense_Mutation_p.I134M	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	bin3, bicoid-interacting 3	603	Bin3-type SAM.						methyltransferase activity			upper_aerodigestive_tract(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTCGCCGGATCTACCGGCACC	0.592			NA											4	67					0	0	0.00024832	0	0
PUS7	54517	broad.mit.edu	37	7	105146653	105146653	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:105146653T>A	uc003vcx.2	-	3	685	c.466A>T	c.(466-468)ATT>TTT	p.I156F	PUS7_uc010lji.2_Missense_Mutation_p.I156F|PUS7_uc003vcy.2_Missense_Mutation_p.I156F|PUS7_uc003vcz.1_Missense_Mutation_p.I156F	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	156					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TCCACTGGAATGGACAAGTCA	0.348	Colon(138;2387 3051 17860)		NA											18	59					0	0	0.000958276	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154644	108154644	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:108154644C>T	uc003vff.1	-	5	1557	c.1150G>A	c.(1150-1152)GAA>AAA	p.E384K	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.E384K|PNPLA8_uc003vfi.1_Missense_Mutation_p.E284K|PNPLA8_uc003vfj.1_Missense_Mutation_p.E384K|PNPLA8_uc003vfk.1_Missense_Mutation_p.E284K	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	384					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						GTCAGTTCTTCAACCCTAGTA	0.378			NA											15	311					0	0	0.000958276	0	0
BRAF	673	broad.mit.edu	37	7	140494148	140494148	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:140494148G>C	uc003vwc.3	-	8	1161	c.1100C>G	c.(1099-1101)CCC>CGC	p.P367R		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	367					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATGCACATTGGGAGCTGATGA	0.398	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				10	110					0	0	0.000673444	0	0
ZNF425	155054	broad.mit.edu	37	7	148802569	148802569	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr7:148802569C>G	uc003wfj.2	-	4	467	c.394G>C	c.(394-396)GAG>CAG	p.E132Q		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	132					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATCTTTCTCTCTTTCCCTCGT	0.433			NA											4	122					0	0	0.00024832	0	0
SGK223	157285	broad.mit.edu	37	8	8235009	8235009	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:8235009C>A	uc003wsh.3	-	2	910	c.910G>T	c.(910-912)GGC>TGC	p.G304C		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	304							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						AAGCTCGGGCCCCGCTTCTCC	0.677	GBM(34;731 755 10259 33573 33867)		NA											6	14					0.000157383	0.00199044	0.000157383	1	0
UNC5D	137970	broad.mit.edu	37	8	35406824	35406824	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:35406824G>A	uc003xjr.1	+	2	446	c.118G>A	c.(118-120)GAA>AAA	p.E40K	UNC5D_uc003xjs.1_Missense_Mutation_p.E35K	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	40	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGACAATGGCGAAGCCCTTCC	0.463			NA											6	23					0	0	8.12818e-05	0	0
KCNB2	9312	broad.mit.edu	37	8	73479988	73479988	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:73479988C>A	uc003xzb.2	+	2	607	c.19C>A	c.(19-21)CCG>ACG	p.P7T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	7	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AAAGGCTCCCCCGGGCTTAAA	0.498			NA											6	76					0.000442599	0.00539561	0.000442599	1	0
CSMD3	114788	broad.mit.edu	37	8	113364700	113364700	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:113364700C>A	uc003ynu.2	-	39	6359	c.6200G>T	c.(6199-6201)AGA>ATA	p.R2067I	CSMD3_uc003yns.2_Missense_Mutation_p.R1269I|CSMD3_uc003ynt.2_Missense_Mutation_p.R2027I|CSMD3_uc011lhx.1_Missense_Mutation_p.R1963I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2067	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACCATATATCTGTCTCCAAT	0.343			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	89					7.48243e-07	1.0471e-05	0.000442599	1	0
WDYHV1	55093	broad.mit.edu	37	8	124440236	124440236	+	Silent	SNP	T	T	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:124440236T>G	uc003yqn.1	+	2	281	c.156T>G	c.(154-156)GCT>GCG	p.A52A	WDYHV1_uc011lij.1_5'UTR|WDYHV1_uc003yqo.1_5'Flank	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	52					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						AATGTTATGCTGTCTTCATAT	0.299			NA											16	296					0	0	0.00074312	0	0
FER1L6	654463	broad.mit.edu	37	8	125072866	125072866	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:125072866C>G	uc003yqw.2	+	24	3269	c.3063C>G	c.(3061-3063)TGC>TGG	p.C1021W	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1021	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCATTGAGTGCGGAGGACAAG	0.547			NA											8	60					0	0	0.000157383	0	0
ASAP1	50807	broad.mit.edu	37	8	131414163	131414164	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:131414163_131414164GG>TT	uc003yta.1	-	1	54_55	c.26_27CC>AA	c.(25-27)TCC>TAA	p.S9*	ASAP1_uc011liw.1_5'UTR	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	9					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						ACGAAAAACTGGAGAGCCTGGA	0.52			NA											14	57					0	0	6.4e-05	0	0
CYP11B2	1585	broad.mit.edu	37	8	143993991	143993991	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr8:143993991G>A	uc003yxk.1	-	8	1356	c.1353C>T	c.(1351-1353)CTC>CTT	p.L451L		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	451					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCGCCGCCCGAGGCACTGGC	0.687			NA							Familial_Hyperaldosteronism_type_I				6	59					0	0	3.59834e-05	0	0
TOPORS	10210	broad.mit.edu	37	9	32542697	32542697	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:32542697C>A	uc003zrb.2	-	3	1993	c.1826G>T	c.(1825-1827)GGG>GTG	p.G609V	TOPORS_uc003zrc.2_Missense_Mutation_p.G542V	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	609	Arg-rich.|Interaction with TOP1.|Interaction with SUMO1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTGATCATGCCCACTTCTACT	0.413			NA											8	235					0.000274275	0.003414	0.000274275	1	0
RECK	8434	broad.mit.edu	37	9	36102158	36102158	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:36102158G>A	uc003zyv.2	+	12	1452	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	RECK_uc003zyw.2_Missense_Mutation_p.E328K|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	456						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CCACACAGCTGAAAGTATTTG	0.353			NA											6	86					0	0	3.59834e-05	0	0
ZNF483	158399	broad.mit.edu	37	9	114304223	114304223	+	Silent	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:114304223G>A	uc004bff.2	+	6	1232	c.1008G>A	c.(1006-1008)AAG>AAA	p.K336K	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	336					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						ATGAAAGCAAGAAACCCTTCA	0.403			NA											9	169					0	0	0.000978159	0	0
GSN	2934	broad.mit.edu	37	9	124076248	124076248	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:124076248G>A	uc004blf.1	+	6	914	c.853G>A	c.(853-855)GAG>AAG	p.E285K	GSN_uc004bld.1_Missense_Mutation_p.E234K|GSN_uc010mvq.1_Missense_Mutation_p.E245K|GSN_uc010mvr.1_Missense_Mutation_p.E245K|GSN_uc010mvu.1_Missense_Mutation_p.E234K|GSN_uc010mvt.1_Missense_Mutation_p.E234K|GSN_uc010mvs.1_Missense_Mutation_p.E234K|GSN_uc004ble.1_Missense_Mutation_p.E234K|GSN_uc010mvv.1_Missense_Mutation_p.E234K|GSN_uc011lyh.1_Missense_Mutation_p.E251K|GSN_uc011lyi.1_Missense_Mutation_p.E234K|GSN_uc011lyj.1_Missense_Mutation_p.E258K|GSN_uc004blg.1_Missense_Mutation_p.E16K	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	285					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						TGCAGGTACCGAGGACACCGC	0.552			NA											9	66					0	0	0.000442599	0	0
ZBTB6	10773	broad.mit.edu	37	9	125673231	125673231	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:125673231T>C	uc004bnh.2	-	2	1210	c.1121A>G	c.(1120-1122)AAC>AGC	p.N374S		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	374	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGTGTATGTTCAAGTGGTC	0.478			NA											4	28					0	0	0.00024832	0	0
SPTAN1	6709	broad.mit.edu	37	9	131370516	131370516	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:131370516C>G	uc004bvl.3	+	34	4565	c.4452C>G	c.(4450-4452)ATC>ATG	p.I1484M	SPTAN1_uc004bvm.3_Missense_Mutation_p.I1484M|SPTAN1_uc004bvn.3_Missense_Mutation_p.I1464M	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1484	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGGCTCTGATCAAAAAACATG	0.493	NSCLC(120;833 1744 2558 35612 37579)		NA											14	187					0	0	0.000422831	0	0
DHRSX	207063	broad.mit.edu	37	X	2161228	2161228	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:2161228C>A	uc004cqf.3	-	6	689	c.640G>T	c.(640-642)GCC>TCC	p.A214S		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	214							binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGGACAAGGGCCAGCTTGCTC	0.642			NA											12	52					7.93312e-07	1.10364e-05	0.000219431	1	0
CNKSR2	22866	broad.mit.edu	37	X	21670428	21670428	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:21670428G>C	uc004czx.1	+	22	2930	c.2894G>C	c.(2893-2895)AGA>ACA	p.R965T	CNKSR2_uc011mjo.1_Missense_Mutation_p.R935T	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	965					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TTTCAGGCCAGAGAAGGGGAA	0.353			NA											3	34					0	0	6.4e-05	0	0
USP11	8237	broad.mit.edu	37	X	47104820	47104820	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:47104820C>G	uc004dhp.2	+	17	2338	c.2338C>G	c.(2338-2340)CGG>GGG	p.R780G	USP11_uc004dhq.2_Missense_Mutation_p.R506G	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	780					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GGCTCCCGTGCGGCTGCAGGA	0.592			NA											4	23					0	0	0.000602214	0	0
KIF4A	24137	broad.mit.edu	37	X	69640065	69640065	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:69640065A>C	uc004dyg.2	+	31	3776	c.3649A>C	c.(3649-3651)AAC>CAC	p.N1217H	KIF4A_uc010nkw.2_Missense_Mutation_p.N1217H|GDPD2_uc010nkx.1_5'Flank|GDPD2_uc010nky.1_5'Flank|GDPD2_uc004dyh.2_5'Flank|GDPD2_uc011mpk.1_5'Flank|GDPD2_uc011mpl.1_5'Flank|GDPD2_uc011mpm.1_5'Flank	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1217	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						TCTGGCCAGCAACACCAGCTT	0.517			NA											3	24					0	0	6.4e-05	0	0
MAGEE1	57692	broad.mit.edu	37	X	75650135	75650136	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:75650135_75650136GG>CT	uc004ecm.1	+	1	2019_2020	c.1812_1813GG>CT	c.(1810-1815)TGGGAA>TGCTAA	p.604_605WE>C*		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	604_605	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CTGAGATTTGGGAAATGCTCTG	0.5			NA											4	29					0	0	6.4e-05	0	0
PCDH11X	27328	broad.mit.edu	37	X	91131897	91131897	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:91131897A>C	uc004efk.1	+	2	1503	c.658A>C	c.(658-660)AAG>CAG	p.K220Q	PCDH11X_uc004efl.1_Missense_Mutation_p.K220Q|PCDH11X_uc004efo.1_Missense_Mutation_p.K220Q|PCDH11X_uc010nmv.1_Missense_Mutation_p.K220Q|PCDH11X_uc004efm.1_Missense_Mutation_p.K220Q|PCDH11X_uc004efn.1_Missense_Mutation_p.K220Q|PCDH11X_uc004efh.1_Missense_Mutation_p.K220Q|PCDH11X_uc004efj.1_Missense_Mutation_p.K220Q	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	220	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GATGAAAGTAAAGGTTGAAGA	0.418	NSCLC(38;925 1092 2571 38200 45895)		NA											4	143					0	0	0.00024832	0	0
COL4A6	1288	broad.mit.edu	37	X	107464479	107464479	+	Silent	SNP	T	T	C			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:107464479T>C	uc004enw.3	-	4	376	c.273A>G	c.(271-273)AAA>AAG	p.K91K	COL4A6_uc004env.3_Silent_p.K90K|COL4A6_uc011msn.1_Silent_p.K90K|COL4A6_uc010npk.2_Silent_p.K90K	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	91	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCTTATCTCCTTTTGGTCCAT	0.458	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				4	171					0	0	3.59834e-05	0	0
NKRF	55922	broad.mit.edu	37	X	118723544	118723544	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:118723544C>A	uc004erq.2	-	2	2497	c.1844G>T	c.(1843-1845)CGC>CTC	p.R615L	NKRF_uc004err.2_Missense_Mutation_p.R615L	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	615	R3H.			AR -> ES (in Ref. 1; CAB56459).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						GCTCTCGGAGCGGGCGTAGTT	0.448			NA											18	109					5.3912e-06	7.3277e-05	0.00074312	1	0
THOC2	57187	broad.mit.edu	37	X	122756691	122756691	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:122756691G>A	uc004etu.2	-	30	3735	c.3703C>T	c.(3703-3705)CAG>TAG	p.Q1235*	THOC2_uc010nqt.1_5'Flank|THOC2_uc004etw.1_Nonsense_Mutation_p.Q56*	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1235					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ACACCACACTGAGATCTCTCC	0.358			NA											10	27					0	0	0.000442599	0	0
THOC2	57187	broad.mit.edu	37	X	122765704	122765704	+	Splice_Site	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:122765704C>A	uc004etu.2	-	22	2349	c.2317_splice	c.e22-1	p.C773_splice	THOC2_uc011muh.1_Splice_Site_p.C698_splice	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2						intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TATCATGACACTAAATTTAAA	0.274			NA											27	165					9.80776e-20	1.57791e-18	0.00106085	1	0
ODZ1	10178	broad.mit.edu	37	X	123805647	123805647	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:123805647C>A	uc004euj.2	-	6	1118	c.1054G>T	c.(1054-1056)GTT>TTT	p.V352F	ODZ1_uc011muj.1_Missense_Mutation_p.V351F|ODZ1_uc010nqy.2_Missense_Mutation_p.V352F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	352	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCTCCTTCAACTGGTTGCAAC	0.458			NA											11	63					1.08611e-07	1.55675e-06	0.000978159	1	0
HAUS7	55559	broad.mit.edu	37	X	152734615	152734616	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chrX:152734615_152734616CC>AA	uc004fho.1	-	2	800_801	c.242_243GG>TT	c.(241-243)TGG>TTT	p.W81F	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Missense_Mutation_p.W81F|HAUS7_uc004fhp.1_RNA|HAUS7_uc011myq.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	81					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0						GGGTACACATCCACTCTAGGAT	0.554			NA											18	125					0	0	6.4e-05	0	0
PRG4	10216	broad.mit.edu	37	1	186276143	186276145	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr1:186276143_186276145delCTC	uc001gru.3	+	7	1343_1345	c.1292_1294delCTC	c.(1291-1296)ACTCCC>ACC	p.P432del	PRG4_uc001grt.3_In_Frame_Del_p.P391del|PRG4_uc009wyl.2_In_Frame_Del_p.P339del|PRG4_uc009wym.2_In_Frame_Del_p.P298del|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	432	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|11; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GCACCCACCACTCCCAAGGAGCC	0.655			NA											7	73	---	---	---	---	NA	NA	NA	NA	NA
CACNA2D4	93589	broad.mit.edu	37	12	1965249	1965249	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr12:1965249delG	uc001qjp.2	-	22	2312	c.2081delC	c.(2080-2082)CCAfs	p.P694fs	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Frame_Shift_Del_p.P558fs|CACNA2D4_uc009zdr.1_5'Flank	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	694	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCGGTGGTCTGGGTCAATATC	0.532	Colon(2;101 179 21030 23310 28141)		NA											9	66	---	---	---	---	NA	NA	NA	NA	NA
VPS4A	27183	broad.mit.edu	37	16	69354959	69354959	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr16:69354959delA	uc002eww.2	+	9	985	c.857delA	c.(856-858)GAAfs	p.E286fs		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	286					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				TCTAGGTTTGAAAAACGAATT	0.542			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
FAM18B	51030	broad.mit.edu	37	17	18694214	18694215	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr17:18694214_18694215delCA	uc002gum.2	+	3	126_127	c.101_102delCA	c.(100-102)CCAfs	p.P34fs	FAM18B_uc002gun.2_5'UTR	NM_016078	NP_057162	Q9NYZ1	F18B1_HUMAN	hypothetical protein LOC51030	34	Helical; (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (53;0.0872)|READ - Rectum adenocarcinoma(1115;0.0967)		TTCAGACATCCAGTAGCATCGT	0.381			NA											38	135	---	---	---	---	NA	NA	NA	NA	NA
RRM2	6241	broad.mit.edu	37	2	10267088	10267088	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr2:10267088delC	uc002rah.2	+	6	847	c.656delC	c.(655-657)GCTfs	p.A219fs		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	219					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		GACAAAGAGGCTACCTATGGT	0.453			NA											23	110	---	---	---	---	NA	NA	NA	NA	NA
PGM5	5239	broad.mit.edu	37	9	71080103	71080103	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6979-01A-11D-1945-08	TCGA-55-6979-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5f246196-f56a-4c81-9ec9-18326dda0b05	e0e09b0c-f948-4919-95fb-5113d82769d6	g.chr9:71080103delG	uc004agr.2	+	7	1367	c.1138delG	c.(1138-1140)GGGfs	p.G380fs		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	380					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						CAATCTGTGTGGGGAAGAGAG	0.483			NA											22	47	---	---	---	---	NA	NA	NA	NA	NA
