Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACOT7	11332	broad.mit.edu	37	1	6387461	6387461	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:6387461C>A	uc001ams.2	-	5	710	c.553G>T	c.(553-555)GAG>TAG	p.E185*	ACOT7_uc010nzq.1_Nonsense_Mutation_p.E70*|ACOT7_uc001amt.2_Nonsense_Mutation_p.E175*|ACOT7_uc001amu.2_RNA|ACOT7_uc001amv.2_RNA|ACOT7_uc001amq.2_Nonsense_Mutation_p.E134*|ACOT7_uc001amr.2_Nonsense_Mutation_p.E155*	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	185						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		TCCTCCTGCTCCTGCCGGGAA	0.637	GBM(74;673 1226 4974 11850 13190)		NA											4	35					1.23904e-05	1.4199e-05	0.000602	1	0
MAD2L2	10459	broad.mit.edu	37	1	11737658	11737658	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:11737658G>A	uc001asp.2	-	4	361	c.173C>T	c.(172-174)CCG>CTG	p.P58L	MAD2L2_uc009vnc.2_Missense_Mutation_p.P58L|MAD2L2_uc001asq.3_Missense_Mutation_p.P58L	NM_006341	NP_006332	Q9UI95	MD2L2_HUMAN	MAD2 homolog	58	Mediates interaction with REV1 and REV3L and homodimerization.|HORMA.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding				0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCAGCTCCGGGTGGCAGGA	0.597			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	41					0	0	0.000978	0	0
TNFRSF8	943	broad.mit.edu	37	1	12186294	12186294	+	Splice_Site	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:12186294G>A	uc001atq.2	+	12	1531	c.1309_splice	c.e12+1	p.D437_splice	TNFRSF8_uc010obc.1_Splice_Site_p.D326_splice|TNFRSF8_uc001atr.2_Splice_Site|TNFRSF8_uc001ats.2_Splice_Site	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,						cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTTGTGGGTGAGTGTCCA	0.657			NA											13	80					0	0	0.004656	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166739	19166739	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:19166739G>A	uc001bba.1	-	6	1875	c.1874C>T	c.(1873-1875)CCC>CTC	p.P625L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	625	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGAGACCTTGGGCGGCCCCAC	0.622			NA											16	85					0	0	0.003163	0	0
HSPG2	3339	broad.mit.edu	37	1	22188551	22188551	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:22188551C>A	uc001bfj.2	-	38	4838	c.4798G>T	c.(4798-4800)GGA>TGA	p.G1600*	HSPG2_uc009vqd.2_Nonsense_Mutation_p.G1601*	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1600	Laminin EGF-like 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTGGCATCTCCGTAGTAGCCA	0.587			NA											45	71					1.06522e-23	1.6288e-23	0.003214	1	0
CNR2	1269	broad.mit.edu	37	1	24202088	24202088	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:24202088G>T	uc001bif.2	-	2	147	c.20C>A	c.(19-21)ACA>AAA	p.T7K		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	7	Extracellular (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GGCTATCTCTGTCACCCAGCA	0.483			NA											52	107					8.99859e-20	1.33331e-19	0.00361	1	0
C1orf63	57035	broad.mit.edu	37	1	25573269	25573269	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:25573269G>A	uc001bjw.2	-	2	438	c.186C>T	c.(184-186)TCC>TCT	p.S62S		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	62	Arg-rich.									pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AACGGGACCTGGACTTGCTCC	0.652			NA											29	96					0	0	0.007291	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33956991	33956991	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:33956991A>G	uc001bxj.3	+	6	1300	c.1133A>G	c.(1132-1134)TAT>TGT	p.Y378C	ZSCAN20_uc001bxk.2_Missense_Mutation_p.Y324C|ZSCAN20_uc009vui.2_Missense_Mutation_p.Y378C	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	378					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CAATGTCGCTATAGGGTCAAA	0.577			NA											17	131					0	0	0.008871	0	0
GJA4	2701	broad.mit.edu	37	1	35260515	35260515	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:35260515G>A	uc001bya.2	+	2	789	c.701G>A	c.(700-702)CGC>CAC	p.R234H	GJA4_uc009vul.2_Missense_Mutation_p.R310H|GJA4_uc009vum.1_Missense_Mutation_p.R234H	NM_002060	NP_002051	P35212	CXA4_HUMAN	connexin 37	234	Cytoplasmic (Potential).				cell-cell junction assembly	integral to plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CTGCTGTGTCGCTGCCTCAGC	0.602			NA											12	58					0	0	0.001368	0	0
GNL2	29889	broad.mit.edu	37	1	38047903	38047903	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:38047903G>A	uc001cbk.2	-	8	993	c.830C>T	c.(829-831)CCA>CTA	p.P277L	GNL2_uc010oif.1_Missense_Mutation_p.P118L	NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	277					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				AGCAAGTGTTGGATAATCCTG	0.433			NA											5	50					0	0	0.001168	0	0
DMBX1	127343	broad.mit.edu	37	1	46976208	46976208	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:46976208C>A	uc001cpx.2	+	2	245	c.230C>A	c.(229-231)GCG>GAG	p.A77E	DMBX1_uc001cpw.2_Missense_Mutation_p.A72E	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	77	Homeobox.|Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGCCGCACAGCGTTCACGGCT	0.587			NA											10	41					0.000442599	0.000483003	0.006214	1	0
ORC1L	4998	broad.mit.edu	37	1	52841232	52841232	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:52841232T>C	uc001ctt.2	-	15	2392	c.2173A>G	c.(2173-2175)ATC>GTC	p.I725V	ORC1L_uc010oni.1_Missense_Mutation_p.I720V|ORC1L_uc001ctu.2_Missense_Mutation_p.I725V|ORC1L_uc009vzd.2_Missense_Mutation_p.I479V	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	725	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						CGCCTGCAGATGTCCAGGCAC	0.532			NA											40	73					0	0	0.006999	0	0
LRRC7	57554	broad.mit.edu	37	1	70504893	70504893	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:70504893C>G	uc001dep.2	+	19	3302	c.3272C>G	c.(3271-3273)CCA>CGA	p.P1091R	LRRC7_uc009wbg.2_Missense_Mutation_p.P375R|LRRC7_uc001deq.2_Missense_Mutation_p.P332R	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1091						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTTTCTCAGCCATCTGTGAAT	0.532			NA											34	66					0	0	0.002836	0	0
IFI44L	10964	broad.mit.edu	37	1	79101021	79101021	+	Splice_Site	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:79101021G>T	uc010oro.1	+	5	903	c.724_splice	c.e5-1	p.Y242_splice	IFI44L_uc010orp.1_Splice_Site|IFI44L_uc010orq.1_Splice_Site	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like							cytoplasm					0						TTTTTTAACAGTATAGGATAT	0.348			NA											11	61					1.58986e-06	1.87085e-06	0.008291	1	0
GBP5	115362	broad.mit.edu	37	1	89726426	89726426	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:89726426C>A	uc001dnc.2	-	12	2259	c.1722G>T	c.(1720-1722)CAG>CAT	p.Q574H	GBP5_uc001dnd.2_Missense_Mutation_p.Q574H	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	574						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAACAGTCCTCTGGGCGTGCT	0.403			NA											26	103					1.88708e-17	2.72694e-17	0.008361	1	0
DPYD	1806	broad.mit.edu	37	1	98015199	98015199	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:98015199C>A	uc001drv.2	-	12	1578	c.1441G>T	c.(1441-1443)GAT>TAT	p.D481Y		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	481	FAD (Potential).				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CCAACGACATCACCACCTGCA	0.428			NA											17	88					3.41278e-10	4.4544e-10	0.00499	1	0
DPYD	1806	broad.mit.edu	37	1	98187196	98187196	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:98187196G>C	uc001drv.2	-	5	490	c.353C>G	c.(352-354)TCT>TGT	p.S118C	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.S118C	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	118					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGGGTTGTCAGAAAATATCAT	0.338			NA											14	99					0	0	0.003163	0	0
OLFM3	118427	broad.mit.edu	37	1	102462361	102462361	+	Silent	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:102462361C>G	uc001dug.2	-	1	430	c.12G>C	c.(10-12)ACG>ACC	p.T4T	OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GAAGGTTGGACGTCGCCTGCA	0.443			NA											10	57					0	0	0.006214	0	0
COL11A1	1301	broad.mit.edu	37	1	103471818	103471818	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:103471818C>A	uc001dul.2	-	16	2055	c.1737G>T	c.(1735-1737)AGG>AGT	p.R579S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.R591S|COL11A1_uc001dun.2_Missense_Mutation_p.R540S|COL11A1_uc009weh.2_Missense_Mutation_p.R463S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	579	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TAAGCCATACCCTTTTTCCAG	0.353			NA											10	67					1.08611e-07	1.31634e-07	0.000978	1	0
WDR47	22911	broad.mit.edu	37	1	109524457	109524457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:109524457C>T	uc001dwj.2	-	13	2672	c.2296G>A	c.(2296-2298)GGC>AGC	p.G766S	WDR47_uc001dwl.2_Missense_Mutation_p.G774S|WDR47_uc001dwi.2_Missense_Mutation_p.G767S|WDR47_uc010ovf.1_Missense_Mutation_p.G691S	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	766	WD 4.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		ATCATCCAGCCACTCCAGGTA	0.383			NA											8	126					0	0	0.00308	0	0
ADORA3	140	broad.mit.edu	37	1	112045664	112045664	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:112045664C>T	uc001ebh.3	-	1	1080	c.313G>A	c.(313-315)GCT>ACT	p.A105T	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Missense_Mutation_p.A105T	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	105	Helical; Name=3; (By similarity).		A -> T (in a colorectal cancer sample; somatic mutation).		activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled	p.A105T(1)		ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	CGGTCCACAGCGATGGCCAGC	0.552			NA											4	41					0	0	0.009096	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:145367767G>A	uc001end.3	+	85	10623	c.10588G>A	c.(10588-10590)GAA>AAA	p.E3530K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3455											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.254			NA											4	69					0	0	0.001984	0	0
THEM4	117145	broad.mit.edu	37	1	151860831	151860831	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:151860831T>C	uc001ezj.1	-	4	654	c.475A>G	c.(475-477)ATG>GTG	p.M159V	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	159					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCATCAATCATGGTTGCAATG	0.398			NA											49	64					0	0	0.00361	0	0
RPTN	126638	broad.mit.edu	37	1	152127445	152127445	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:152127445G>T	uc001ezs.1	-	3	2195	c.2130C>A	c.(2128-2130)GGC>GGA	p.G710G		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	710	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						AAGTTTGATGGCCCTGCTCTT	0.567			NA											190	188					4.72421e-73	7.83891e-73	0.00361	1	0
HRNR	388697	broad.mit.edu	37	1	152192519	152192519	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:152192519C>A	uc001ezt.1	-	3	1662	c.1586G>T	c.(1585-1587)GGA>GTA	p.G529V		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	529	5.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCGGCTGTGTCCCAAAGATTG	0.567			NA											16	439					1.3612e-06	1.6126e-06	0.003163	1	0
CD1A	909	broad.mit.edu	37	1	158225078	158225078	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158225078G>A	uc001frt.2	+	2	796	c.263G>A	c.(262-264)CGT>CAT	p.R88H		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	88	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACATTATTCCGTATACGCACC	0.488			NA											18	74					0	0	0.00499	0	0
CD1C	911	broad.mit.edu	37	1	158262005	158262005	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158262005G>T	uc001fru.2	+	3	752	c.460G>T	c.(460-462)GGC>TGC	p.G154C	CD1C_uc001frv.2_Translation_Start_Site	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	154	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GCCATCTCCAGGCTGTGGAAG	0.458			NA											57	350					2.48909e-17	3.58701e-17	0.00361	1	0
OR10X1	128367	broad.mit.edu	37	1	158549373	158549373	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158549373C>T	uc010pin.1	-	1	317	c.317G>A	c.(316-318)AGA>AAA	p.R106K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGAAATGCTTCTGTCCTTGGC	0.478			NA											7	140					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158627350	158627350	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158627350G>T	uc001fst.1	-	19	2921	c.2722C>A	c.(2722-2724)CTG>ATG	p.L908M		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	908	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCTTCATGCAGGTCAGCCAGG	0.483			NA											24	271					1.85244e-09	2.35928e-09	0.00333	1	0
OR6K2	81448	broad.mit.edu	37	1	158670208	158670208	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158670208G>C	uc001fsu.1	-	1	235	c.235C>G	c.(235-237)CCA>GCA	p.P79A		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGCATCTTTGGGATTGTGGCT	0.463			NA											24	98					0	0	0.00278	0	0
OR6K6	128371	broad.mit.edu	37	1	158724731	158724731	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:158724731C>G	uc001fsw.1	+	1	126	c.126C>G	c.(124-126)TTC>TTG	p.F42L		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	42	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					AGTTCCTCTTCTCTATGTTCC	0.428			NA											22	249					0	0	0.002299	0	0
OR10J3	441911	broad.mit.edu	37	1	159283771	159283771	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:159283771G>T	uc010piu.1	-	1	679	c.679C>A	c.(679-681)CTT>ATT	p.L227I		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GCAATCTTAAGAATGGTGGAG	0.488			NA											92	97					1.40862e-40	2.31542e-40	0.00361	1	0
FCRLA	84824	broad.mit.edu	37	1	161681008	161681009	+	Missense_Mutation	DNP	CC	CC	AT	rs142998045		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:161681008_161681009CC>AT	uc001gbe.2	+	4	554_555	c.312_313CC>AT	c.(310-315)ATCCTC>ATATTC	p.L105F	FCRLA_uc001gbd.2_Missense_Mutation_p.L99F|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	82	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			ACTGGCTGATCCTCCAAGGTCC	0.589			NA											28	28					0	0	0.004672	0	0
DDR2	4921	broad.mit.edu	37	1	162740157	162740157	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:162740157G>C	uc001gcf.2	+	13	1824	c.1359G>C	c.(1357-1359)ATG>ATC	p.M453I	DDR2_uc001gcg.2_Missense_Mutation_p.M453I	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	453	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ATTCTAGCATGTTCAACAATA	0.517	NSCLC(161;314 2006 8283 19651 23192)		NA											37	242					0	0	0.004878	0	0
PBX1	5087	broad.mit.edu	37	1	164761873	164761873	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:164761873T>C	uc001gct.2	+	3	666	c.408T>C	c.(406-408)TCT>TCC	p.S136S	PBX1_uc010pku.1_Silent_p.S136S|PBX1_uc010pkv.1_Silent_p.S53S|PBX1_uc001gcs.2_Silent_p.S136S|PBX1_uc010pkw.1_Silent_p.S26S	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	136					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						cggcggcTTCTGGAGGGGCAG	0.478			NA	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								11	61					0	0	0.001368	0	0
CD247	919	broad.mit.edu	37	1	167403267	167403267	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:167403267A>G	uc001gei.3	-	6	528	c.383T>C	c.(382-384)ATG>ACG	p.M128T	CD247_uc001gej.3_Missense_Mutation_p.M127T	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	128	Cytoplasmic (Potential).|ITAM 2.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			CTCGCCTTTCATCCCAATCTC	0.507	Ovarian(192;1815 2869 36877 43334)		NA											10	260					0	0	0.000978	0	0
BAT2L2	23215	broad.mit.edu	37	1	171505341	171505341	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:171505341G>T	uc010pmg.1	+	14	2477	c.2211G>T	c.(2209-2211)TGG>TGT	p.W737C		NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	737	Pro-rich.						protein C-terminus binding				0						ATCCAAGGTGGCTCATGATGC	0.473			NA											22	24					1.22574e-08	1.53144e-08	0.002299	1	0
TNR	7143	broad.mit.edu	37	1	175292530	175292530	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:175292530A>T	uc001gkp.1	-	21	4121	c.4040T>A	c.(4039-4041)CTC>CAC	p.L1347H	TNR_uc009wwu.1_Missense_Mutation_p.L1347H	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1347					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCCTGCCATGAGACGGTGGTT	0.468			NA											11	110					0	0	0.001368	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659540	176659540	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:176659540C>T	uc001gkz.2	+	5	3569	c.2405C>T	c.(2404-2406)CCG>CTG	p.P802L	PAPPA2_uc001gky.1_Missense_Mutation_p.P802L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	802					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCAGGGGCTCCGTTCACCAAC	0.567			NA											11	139					0	0	0.001368	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738905	176738905	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:176738905C>T	uc001gkz.2	+	16	5650	c.4486C>T	c.(4486-4488)CCA>TCA	p.P1496S	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1496	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTGTGTCCCACCAGCCAAGCT	0.512			NA											43	187					0	0	0.00874	0	0
PAPPA2	60676	broad.mit.edu	37	1	176759022	176759022	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:176759022C>A	uc001gkz.2	+	18	5957	c.4793C>A	c.(4792-4794)CCC>CAC	p.P1598H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1598	Sushi 4.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGTGAGCCACCCCCTCCTGTG	0.478			NA											33	128					1.21669e-08	1.52376e-08	0.003271	1	0
FAM5B	57795	broad.mit.edu	37	1	177250481	177250481	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:177250481C>T	uc001glf.2	+	8	2481	c.2169C>T	c.(2167-2169)CTC>CTT	p.L723L	FAM5B_uc001glg.2_Silent_p.L618L	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	723						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCATTGAGCTCAGGGACCGGG	0.537			NA											25	162					0	0	0.00278	0	0
RGS8	85397	broad.mit.edu	37	1	182640815	182640815	+	Translation_Start_Site	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:182640815C>A	uc010pnw.1	-	2	132	c.-126G>T	c.(-128--124)CAGGC>CATGC		RGS8_uc001gpn.1_Translation_Start_Site|RGS8_uc001gpm.1_Missense_Mutation_p.Q19H	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						TCCTCATGGCCTGAGGGTCTT	0.463	Ovarian(189;1262 3804 41973)		NA											44	66					2.40228e-13	3.36063e-13	0.003214	1	0
F13B	2165	broad.mit.edu	37	1	197026189	197026189	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:197026189C>T	uc001gtt.1	-	7	1169	c.1125G>A	c.(1123-1125)GAG>GAA	p.E375E		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	375	Sushi 6.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TACAAGTTATCTCATTCGATC	0.368			NA											26	48					0	0	0.00632	0	0
ASPM	259266	broad.mit.edu	37	1	197070480	197070480	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:197070480T>C	uc001gtu.2	-	18	8158	c.7901A>G	c.(7900-7902)CAT>CGT	p.H2634R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.H482R	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2634	IQ 28.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GGCTTTACAATGCTTCTGAAT	0.378			NA											13	32					0	0	0.001368	0	0
NAV1	89796	broad.mit.edu	37	1	201777944	201777944	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:201777944C>A	uc001gwu.2	+	19	4490	c.4143C>A	c.(4141-4143)CGC>CGA	p.R1381R	NAV1_uc001gwx.2_Silent_p.R990R	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1384					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CTTCCCCACGCCGCTCCCTAG	0.567			NA											23	119					2.39556e-15	3.38728e-15	0.00278	1	0
OPTC	26254	broad.mit.edu	37	1	203468946	203468946	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:203468946C>A	uc001gzu.1	+	5	815	c.699C>A	c.(697-699)CTC>CTA	p.L233L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	233						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			TAAATCGGCTCCAGAGCTCGG	0.443			NA											27	75					9.04412e-07	1.07629e-06	0.004656	1	0
NFASC	23114	broad.mit.edu	37	1	204924038	204924038	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:204924038C>A	uc001hbj.2	+	7	822	c.494C>A	c.(493-495)CCG>CAG	p.P165Q	NFASC_uc001hbh.2_Missense_Mutation_p.P165Q|NFASC_uc010pqz.1_Missense_Mutation_p.P159Q|NFASC_uc010pra.1_Missense_Mutation_p.P159Q|NFASC_uc001hbi.2_Missense_Mutation_p.P159Q|NFASC_uc009xbg.1_Missense_Mutation_p.P232Q|NFASC_uc010prb.1_Missense_Mutation_p.P159Q|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_5'Flank	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	165	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCAACCCCCCGCCTGGACTT	0.567			NA											74	220					1.76421e-39	2.87299e-39	0.00361	1	0
USH2A	7399	broad.mit.edu	37	1	215847560	215847560	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:215847560A>C	uc001hku.1	-	63	14080	c.13693T>G	c.(13693-13695)TAT>GAT	p.Y4565D		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4565	Fibronectin type-III 31.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGAGGGTATAATTGATGATA	0.403			NA								HNSCC(13;0.011)			8	178					0	0	0.004482	0	0
MIA3	375056	broad.mit.edu	37	1	222838929	222838929	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:222838929G>C	uc001hnl.2	+	28	5701	c.5692G>C	c.(5692-5694)GAC>CAC	p.D1898H	MIA3_uc001hnm.2_Missense_Mutation_p.D776H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1898	Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CACTAGCCAGGACTGTTCACA	0.478			NA											13	172					0	0	0.001855	0	0
CNIH3	149111	broad.mit.edu	37	1	224804820	224804820	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:224804820G>T	uc001hos.1	+	1	642	c.-56G>T	c.(-58--54)GAGGC>GATGC			NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3						intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		CCTCTAGGGAGGCATCGGGCT	0.647			NA											85	188					1.11057e-38	1.80297e-38	0.00361	1	0
RYR2	6262	broad.mit.edu	37	1	237819198	237819198	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:237819198G>T	uc001hyl.1	+	53	8163	c.8043G>T	c.(8041-8043)ATG>ATT	p.M2681I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2681	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGACTACATGGAGTCAAATT	0.423			NA											16	20					1.3612e-06	1.6126e-06	0.003163	1	0
ZP4	57829	broad.mit.edu	37	1	238048824	238048824	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:238048824G>C	uc001hym.2	-	8	1027	c.1027C>G	c.(1027-1029)CGG>GGG	p.R343G	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	343	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATGGGATCCCGAAGCAACTTC	0.498	NSCLC(166;160 2029 11600 18754 19936)		NA											5	75					0	0	0.000602	0	0
OR2G2	81470	broad.mit.edu	37	1	247752559	247752559	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:247752559G>C	uc010pyy.1	+	1	898	c.898G>C	c.(898-900)GTG>CTG	p.V300L		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GATCAAGGAGGTGAAAGGGGC	0.363			NA											47	125					0	0	0.00361	0	0
OR6F1	343169	broad.mit.edu	37	1	247875588	247875588	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:247875588G>C	uc001idj.1	-	1	470	c.470C>G	c.(469-471)GCA>GGA	p.A157G		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGTGGGCACTGCAATGGCCAC	0.597			NA											22	87					0	0	0.002299	0	0
OR2L13	284521	broad.mit.edu	37	1	248262885	248262885	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:248262885C>T	uc001ids.2	+	3	545	c.208C>T	c.(208-210)CTG>TTG	p.L70L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CCTTATGGACCTGATGTACAT	0.547			NA											36	188					0	0	0.004289	0	0
OR2T34	127068	broad.mit.edu	37	1	248737448	248737448	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr1:248737448G>T	uc001iep.1	-	1	611	c.611C>A	c.(610-612)ACG>AAG	p.T204K		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCACAGGTACGTGAGCATCTT	0.517			NA											85	497					3.7744e-50	6.22361e-50	0.00361	1	0
TUBB8	347688	broad.mit.edu	37	10	93213	93213	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:93213G>A	uc001ifi.2	-	4	1119	c.1119C>T	c.(1117-1119)GCC>GCT	p.A373A	TUBB8_uc009xhe.2_Silent_p.A336A|TUBB8_uc010pzs.1_Silent_p.A301A	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	373					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GTTCCTGGATGGCCGTATTAT	0.537	Pancreas(192;2041 3010 9013 18103)		NA											22	124					0	0	0.005443	0	0
CALML5	51806	broad.mit.edu	37	10	5541168	5541168	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:5541168G>A	uc001iic.2	-	1	366	c.234C>T	c.(232-234)GCC>GCT	p.A78A		NM_017422	NP_059118	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	78	EF-hand 3.				epidermis development|signal transduction		calcium ion binding|protein binding				0						CCTCCAGGCCGGCCCTGGCCT	0.682	GBM(149;1055 3356 43077)		NA											6	44					0	0	0.004007	0	0
GATA3	2625	broad.mit.edu	37	10	8115719	8115719	+	Silent	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:8115719T>A	uc001ika.2	+	6	1622	c.1065T>A	c.(1063-1065)ACT>ACA	p.T355T	GATA3_uc001ijz.2_Silent_p.T356T	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	355					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding	p.M357fs*14(1)		breast(17)|ovary(3)|central_nervous_system(2)	22						GACCCCTGACTATGAAGAAGG	0.393			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						10	49					0	0	0.006214	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14950843	14950843	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:14950843C>T	uc001inn.2	-	14	1728	c.1643G>A	c.(1642-1644)AGT>AAT	p.S548N	DCLRE1C_uc010qbx.1_Intron|DCLRE1C_uc001ink.2_Missense_Mutation_p.S201N|DCLRE1C_uc001inl.2_Missense_Mutation_p.S428N|DCLRE1C_uc009xji.2_Missense_Mutation_p.S433N|DCLRE1C_uc001inm.2_Missense_Mutation_p.S428N|DCLRE1C_uc001ino.2_Missense_Mutation_p.S433N|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Missense_Mutation_p.S428N|DCLRE1C_uc001inq.2_Missense_Mutation_p.S428N|DCLRE1C_uc001inr.2_Missense_Mutation_p.S433N	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	548				S->A: Reduced IR induced phosphorylation; when associated with A-516; A-534; A-538; A-553; A-561 and A-562.	DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						CCAGCCTTGACTTCCTTGTTC	0.443			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					24	100					0	0	0.00278	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290663	15290663	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:15290663C>A	uc001iob.2	-	5	736	c.729G>T	c.(727-729)GCG>GCT	p.A243A		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	243	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						ACCGCCACGCCGCGACATAGG	0.557			NA											20	73					2.4624e-09	3.11351e-09	0.008871	1	0
CUBN	8029	broad.mit.edu	37	10	16942660	16942660	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:16942660C>G	uc001ioo.2	-	53	8426	c.8374G>C	c.(8374-8376)GGT>CGT	p.G2792R	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.G148R	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2792	CUB 20.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAAAATCCACCACCTTGCAAT	0.368			NA											35	71					0	0	0.006999	0	0
RET	5979	broad.mit.edu	37	10	43606878	43606878	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:43606878C>G	uc001jal.2	+	7	1677	c.1487C>G	c.(1486-1488)GCC>GGC	p.A496G	RET_uc001jak.1_Missense_Mutation_p.A496G|RET_uc010qez.1_Missense_Mutation_p.A242G	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	496	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCTAGGCAGGCCCAGGCCCAG	0.647	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				5	30					0	0	0.000602	0	0
CDHR1	92211	broad.mit.edu	37	10	85968063	85968063	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:85968063C>A	uc001kcv.2	+	11	1097	c.1097C>A	c.(1096-1098)TCC>TAC	p.S366Y	CDHR1_uc001kcw.2_Missense_Mutation_p.S366Y|CDHR1_uc009xst.2_Missense_Mutation_p.S125Y	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	366	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TTTGAGCTGTCCATGAATGAG	0.597			NA											9	55					0.00448238	0.00475349	0.004482	1	0
PAPSS2	9060	broad.mit.edu	37	10	89503231	89503231	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:89503231C>T	uc001kex.2	+	10	1572	c.1309C>T	c.(1309-1311)CCG>TCG	p.P437S	PAPSS2_uc001kew.2_Missense_Mutation_p.P442S	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	437	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CTACAAGCACCCGGTCCTCCT	0.607			NA											14	96					0	0	0.00245	0	0
CC2D2B	387707	broad.mit.edu	37	10	97773580	97773580	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:97773580T>C	uc001kll.2	+	5	553	c.354T>C	c.(352-354)TTT>TTC	p.F118F	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Silent_p.F118F	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	118										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TGATTCCTTTTGTGCCTAATA	0.199			NA											11	22					0	0	0.003163	0	0
TLL2	7093	broad.mit.edu	37	10	98180730	98180730	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:98180730G>T	uc001kml.1	-	7	1132	c.906C>A	c.(904-906)GCC>GCA	p.A302A	TLL2_uc009xvf.1_Silent_p.A250A	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	302	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGGTGTTCCGGGCGTAGTGCA	0.507			NA											39	187					2.2871e-25	3.54871e-25	0.007835	1	0
PDCD11	22984	broad.mit.edu	37	10	105166456	105166456	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:105166456C>T	uc001kwy.1	+	7	866	c.779C>T	c.(778-780)TCA>TTA	p.S260L		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	260					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTTGGTCACTCAGAGGTTTCT	0.478			NA											15	81					0	0	0.003163	0	0
C10orf90	118611	broad.mit.edu	37	10	128192773	128192773	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:128192773G>A	uc001ljq.2	-	3	1117	c.996C>T	c.(994-996)GGC>GGT	p.G332G	C10orf90_uc001ljp.2_Silent_p.G285G|C10orf90_uc010qum.1_Silent_p.G429G|C10orf90_uc009yao.2_Silent_p.G429G|C10orf90_uc001ljs.1_Silent_p.G285G	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	332										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TCCAGCGCTGGCCTACGAGGT	0.547			NA									OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	79					0	0	0.001368	0	0
NLRP6	171389	broad.mit.edu	37	11	284376	284376	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:284376C>A	uc010qvs.1	+	6	2348	c.2348C>A	c.(2347-2349)CCG>CAG	p.P783Q	NLRP6_uc010qvt.1_Missense_Mutation_p.P782Q	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	783						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTAGCCTGGCCGCAGTGCAGG	0.711			NA											3	29					0.00024832	0.000272685	0.009096	1	0
NLRP14	338323	broad.mit.edu	37	11	7059831	7059831	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:7059831C>T	uc001mfb.1	+	2	337	c.14C>T	c.(13-15)TCA>TTA	p.S5L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	5	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GCAGATTCATCATCATCTTCT	0.368			NA											12	100					0	0	0.000978	0	0
NLRP10	338322	broad.mit.edu	37	11	7982770	7982770	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:7982770G>A	uc001mfv.1	-	2	406	c.389C>T	c.(388-390)CCC>CTC	p.P130L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	130							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCTGAGCTGGGCTTGGCCAC	0.562			NA											12	60					0	0	0.001855	0	0
NAV2	89797	broad.mit.edu	37	11	20070445	20070445	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:20070445G>A	uc010rdm.1	+	16	4504	c.4143G>A	c.(4141-4143)AAG>AAA	p.K1381K	NAV2_uc001mpp.2_Silent_p.K1294K|NAV2_uc001mpr.3_Silent_p.K1358K|NAV2_uc001mpt.2_Silent_p.K444K|NAV2_uc009yhx.2_Silent_p.K444K|NAV2_uc009yhy.1_Silent_p.K357K|NAV2_uc009yhz.2_Silent_p.K40K	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1381	Ser-rich.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TCTACAGCAAGAATGTGGACC	0.612			NA											32	101					0	0	0.002445	0	0
BBOX1	8424	broad.mit.edu	37	11	27077157	27077157	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:27077157G>T	uc001mre.1	+	3	548	c.180G>T	c.(178-180)GTG>GTT	p.V60V	BBOX1_uc009yih.1_Silent_p.V60V|BBOX1_uc001mrg.1_Silent_p.V60V	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	60					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	CTCTTGATGTGAACATTGGAA	0.408			NA											14	39					1.05317e-09	1.35776e-09	0.00245	1	0
MYBPC3	4607	broad.mit.edu	37	11	47360146	47360146	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:47360146C>T	uc001nfa.3	-	22	2288	c.2233G>A	c.(2233-2235)GAT>AAT	p.D745N	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	744	Ig-like C2-type 5.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		ACGCCCTCATCTTCCTTCTCT	0.647			NA											24	30					0	0	0.003954	0	0
PTPRJ	5795	broad.mit.edu	37	11	48177639	48177639	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:48177639A>G	uc001ngp.3	+	21	3761	c.3406A>G	c.(3406-3408)ATT>GTT	p.I1136V		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1136	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ATATGCCATCATTATGTTGAC	0.313			NA											17	147					0	0	0.004007	0	0
TRIM48	79097	broad.mit.edu	37	11	55033135	55033135	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55033135C>A	uc010rid.1	+	3	605	c.519C>A	c.(517-519)AAC>AAA	p.N173K		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	157						intracellular	zinc ion binding				0						ATCAGAGAAACCTGAATGTGG	0.408			NA											8	62					0.00829132	0.00873995	0.008291	1	0
OR4A15	81328	broad.mit.edu	37	11	55136282	55136282	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55136282C>A	uc010rif.1	+	1	923	c.923C>A	c.(922-924)CCC>CAC	p.P308H		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	308	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTATAACTCCCATGCTGAAC	0.383			NA											71	178					6.00099e-30	9.47904e-30	0.00361	1	0
OR4C15	81309	broad.mit.edu	37	11	55322196	55322196	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55322196C>T	uc010rig.1	+	1	414	c.414C>T	c.(412-414)TCC>TCT	p.S138S		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTGTAGACTCCCTCTATGTGA	0.488			NA								HNSCC(20;0.049)			30	162					0	0	0.008361	0	0
OR4C15	81309	broad.mit.edu	37	11	55322292	55322292	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55322292C>T	uc010rig.1	+	1	510	c.510C>T	c.(508-510)GCC>GCT	p.A170A		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCCTCACAGCCATGGCCTATG	0.493			NA								HNSCC(20;0.049)			10	116					0	0	0.006214	0	0
OR4S2	219431	broad.mit.edu	37	11	55419211	55419211	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55419211C>A	uc001nhs.1	+	1	832	c.832C>A	c.(832-834)CCC>ACC	p.P278T		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CATTATCACTCCCATGTTAAA	0.408			NA											50	165					5.13769e-22	7.83311e-22	0.00361	1	0
OR5L2	26338	broad.mit.edu	37	11	55595447	55595447	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:55595447C>T	uc001nhy.1	+	1	753	c.753C>T	c.(751-753)TCC>TCT	p.S251S		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TCACTGTCTCCCATGGAACAA	0.498			NA								HNSCC(27;0.073)			26	87					0	0	0.007291	0	0
SERPING1	710	broad.mit.edu	37	11	57379371	57379371	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:57379371C>T	uc001nkp.1	+	7	1402	c.1211C>T	c.(1210-1212)ACG>ATG	p.T404M	SERPING1_uc001nkq.1_Missense_Mutation_p.T367M|SERPING1_uc010rju.1_Missense_Mutation_p.T352M|SERPING1_uc010rjv.1_Missense_Mutation_p.T409M|SERPING1_uc001nkr.1_Missense_Mutation_p.T404M|SERPING1_uc009ymi.1_Missense_Mutation_p.T413M|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Missense_Mutation_p.T95M	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	404					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						ATCAAAGTGACGACCAGCCAG	0.507			NA							Hereditary_Angioedema				17	79					0	0	0.006122	0	0
GLYAT	10249	broad.mit.edu	37	11	58478160	58478160	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:58478160G>A	uc001nnb.2	-	5	546	c.391C>T	c.(391-393)CGC>TGC	p.R131C	GLYAT_uc001nnc.2_Missense_Mutation_p.R131C	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	131					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TAGAGAATGCGTTGTGTTTGT	0.428			NA											9	135					0	0	0.004482	0	0
ATG2A	23130	broad.mit.edu	37	11	64662780	64662780	+	Silent	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:64662780G>C	uc001obx.2	-	40	5677	c.5562C>G	c.(5560-5562)GCC>GCG	p.A1854A	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Silent_p.A619A	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1854							protein binding			ovary(1)|central_nervous_system(1)	2						CTGTGTCGTAGGCCTTGGCCA	0.716			NA											8	55					0	0	0.006214	0	0
TPCN2	219931	broad.mit.edu	37	11	68822749	68822749	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:68822749C>G	uc001oos.2	+	4	474	c.358C>G	c.(358-360)CCG>GCG	p.P120A	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Missense_Mutation_p.P120A	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	120	Extracellular (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCCTGGGAGCCGCCCTGCGG	0.637			NA											19	96					0	0	0.008871	0	0
PPFIA1	8500	broad.mit.edu	37	11	70171605	70171605	+	Splice_Site	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:70171605G>T	uc001opo.2	+	5	730	c.532_splice	c.e5-1	p.V178_splice	PPFIA1_uc001opn.1_Splice_Site_p.V178_splice|PPFIA1_uc001opp.2_Splice_Site|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b						cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TTTATTTTCAGGTGAGAGAGC	0.328			NA											42	79					1.34996e-11	1.82072e-11	0.009718	1	0
C2CD3	26005	broad.mit.edu	37	11	73820134	73820134	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:73820134C>A	uc001ouu.2	-	12	2134	c.1907G>T	c.(1906-1908)TGG>TTG	p.W636L		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	636						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GGAATTCCACCAGTGCTCTAT	0.438			NA											30	42					2.4375e-19	3.60147e-19	0.007291	1	0
C2CD3	26005	broad.mit.edu	37	11	73844552	73844552	+	Missense_Mutation	SNP	T	T	C	rs138239571		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:73844552T>C	uc001ouu.2	-	6	1233	c.1006A>G	c.(1006-1008)ATG>GTG	p.M336V	C2CD3_uc001ouv.2_Missense_Mutation_p.M336V	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	336						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CTTGATTTCATTGCAGAAATC	0.403			NA											11	34					0	0	0.008291	0	0
INTS4	92105	broad.mit.edu	37	11	77702195	77702195	+	Missense_Mutation	SNP	C	C	T	rs144227709		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:77702195C>T	uc001oys.2	-	2	233	c.205G>A	c.(205-207)GTA>ATA	p.V69I	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.V69I|INTS4_uc001oyv.1_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	69	HEAT 1.				snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			ACTCCCTCTACGCTTTCCGCC	0.463			NA											11	109					0	0	0.001855	0	0
PRCP	5547	broad.mit.edu	37	11	82549566	82549566	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:82549566C>T	uc001ozs.2	-	8	1250	c.1137G>A	c.(1135-1137)ATG>ATA	p.M379I	PRCP_uc001ozr.2_Missense_Mutation_p.M400I	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	379					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						GAGGTTCAAACATGTCATCGA	0.398			NA											12	61					0	0	0.001368	0	0
HEPHL1	341208	broad.mit.edu	37	11	93822121	93822121	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:93822121G>A	uc001pep.2	+	12	2438	c.2281G>A	c.(2281-2283)GCA>ACA	p.A761T	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	761	Plastocyanin-like 5.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GCACGTGGACGCAAGAGGGGA	0.542			NA											9	83					0	0	0.004482	0	0
PGR	5241	broad.mit.edu	37	11	100933199	100933199	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:100933199T>A	uc001pgh.2	-	4	2934	c.2191A>T	c.(2191-2193)AAG>TAG	p.K731*	PGR_uc001pgg.2_Nonsense_Mutation_p.K112*|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	731	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TTAGACCACTTGACTACTGAA	0.333	Pancreas(124;2271 2354 21954 22882)		NA											52	112					0	0	0.00361	0	0
SIK2	23235	broad.mit.edu	37	11	111594504	111594504	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:111594504C>T	uc001plt.2	+	15	2550	c.2432C>T	c.(2431-2433)GCT>GTT	p.A811V		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	811					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						CCCCGGGCTGCTCCTCCTCTG	0.512			NA											27	132					0	0	0.005443	0	0
SIK2	23235	broad.mit.edu	37	11	111594549	111594549	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:111594549C>T	uc001plt.2	+	15	2595	c.2477C>T	c.(2476-2478)CCA>CTA	p.P826L		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	826					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						ccgccaccgccaccaccccct	0.517			NA											18	47					0	0	0.00499	0	0
CBL	867	broad.mit.edu	37	11	119149351	119149351	+	Silent	SNP	A	A	G	rs34732429		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:119149351A>G	uc001pwe.2	+	9	1497	c.1359A>G	c.(1357-1359)CCA>CCG	p.P453P		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	453	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTCCCTCCCCAAATTATGATG	0.478			NA							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				16	65					0	0	0.006122	0	0
MCAM	4162	broad.mit.edu	37	11	119182639	119182639	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:119182639C>A	uc001pwf.2	-	10	1193	c.1164G>T	c.(1162-1164)AGG>AGT	p.R388S	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	388	Ig-like C2-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		GCACAGGCCCCCTTTCCAGCA	0.632			NA											22	119					5.35356e-11	7.07531e-11	0.00278	1	0
OR10G9	219870	broad.mit.edu	37	11	123894335	123894335	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:123894335G>T	uc010sad.1	+	1	616	c.616G>T	c.(616-618)GCC>TCC	p.A206S		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGGGCTAGTGGCCTCGGGCTG	0.547			NA											29	204					8.58068e-18	1.25026e-17	0.007291	1	0
OR8B8	26493	broad.mit.edu	37	11	124310129	124310129	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:124310129G>T	uc010sal.1	-	1	853	c.853C>A	c.(853-855)CTC>ATC	p.L285I		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATGGGTTGAGCATGGGCACC	0.423			NA											27	78					3.73988e-18	5.46438e-18	0.00632	1	0
STT3A	3703	broad.mit.edu	37	11	125478177	125478177	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr11:125478177G>T	uc001qcd.2	+	9	1064	c.954G>T	c.(952-954)ATG>ATT	p.M318I	STT3A_uc009zbm.2_Missense_Mutation_p.M318I|STT3A_uc001qce.2_Missense_Mutation_p.M318I|STT3A_uc010sbg.1_Missense_Mutation_p.M226I|STT3A_uc009zbn.2_Missense_Mutation_p.M92I	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	318	Helical; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		CTCTCCTCATGCTGACAGGTA	0.328			NA											33	70					3.11337e-16	4.43804e-16	0.002836	1	0
Unknown	0	broad.mit.edu	37	12	92018	92018	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:92018T>C	uc010sdi.1	-	2	320	c.292A>G	c.(292-294)AGT>GGT	p.S98G	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;												NA						GACTCCACACTCTCCTGGGTT	0.592			NA											3	9					0	0	0.004672	0	0
TULP3	7289	broad.mit.edu	37	12	3040232	3040232	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:3040232C>T	uc010seh.1	+	6	603	c.522C>T	c.(520-522)GCC>GCT	p.A174A	TULP3_uc010sef.1_RNA|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Silent_p.A174A|TULP3_uc010sei.1_Silent_p.A31A	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	174				TSGSATAAQPADNL -> IPVLLLPPNQLITF (in Ref. 1).	G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CTGCTACTGCCGCCCAACCAG	0.488			NA											34	122					0	0	0.005524	0	0
CD163	9332	broad.mit.edu	37	12	7639341	7639341	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:7639341C>T	uc001qsz.3	-	10	2340	c.2212G>A	c.(2212-2214)GGC>AGC	p.G738S	CD163_uc001qta.3_Missense_Mutation_p.G738S|CD163_uc009zfw.2_Missense_Mutation_p.G771S	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	738	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CCCCAGGAGCCCTCATGATAG	0.517			NA											46	123					0	0	0.00361	0	0
CD163	9332	broad.mit.edu	37	12	7640527	7640527	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:7640527G>C	uc001qsz.3	-	7	1705	c.1577C>G	c.(1576-1578)TCT>TGT	p.S526C	CD163_uc001qta.3_Missense_Mutation_p.S526C|CD163_uc009zfw.2_Missense_Mutation_p.S526C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	526	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CCCCAGGATAGAGACAACTGT	0.527			NA											5	88					0	0	0.000602	0	0
CLEC4C	170482	broad.mit.edu	37	12	7882323	7882323	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:7882323C>A	uc001qtg.1	-	6	685	c.511G>T	c.(511-513)GGT>TGT	p.G171C	CLEC4C_uc001qth.1_Missense_Mutation_p.G171C|CLEC4C_uc001qti.1_Missense_Mutation_p.G140C	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	171	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		TTGGGTTCACCTGAGTGCCAG	0.448			NA											36	148					3.09479e-21	4.67775e-21	0.006999	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21069086	21069086	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:21069086G>T	uc001rek.2	+	15	2140	c.2014G>T	c.(2014-2016)GAA>TAA	p.E672*	SLCO1B3_uc001rel.2_Nonsense_Mutation_p.E672*|SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	672	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AGCAAACTTAGAATTCTTAAA	0.318			NA											31	34					5.77227e-19	8.5048e-19	0.008361	1	0
ABCC9	10060	broad.mit.edu	37	12	21970206	21970206	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:21970206C>A	uc001rfi.1	-	31	3827	c.3807G>T	c.(3805-3807)TTG>TTT	p.L1269F	ABCC9_uc001rfh.2_Missense_Mutation_p.L1269F|ABCC9_uc001rfj.1_Missense_Mutation_p.L1233F	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1269	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCAGGTCAGCCAAGTTCCTCA	0.378			NA											19	152					1.37522e-17	1.99275e-17	0.007413	1	0
CMAS	55907	broad.mit.edu	37	12	22208541	22208542	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:22208541_22208542GG>TT	uc001rfm.2	+	3	635_636	c.556_557GG>TT	c.(556-558)GGA>TTA	p.G186L	CMAS_uc001rfn.2_RNA	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	186					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						AATTCAGAAAGGAGGTAATCTC	0.342			NA											32	56					0	0	0.004672	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	T	rs121913530		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:25398285C>T	uc001rgp.1	-	2	215	c.34G>A	c.(34-36)GGT>AGT	p.G12S	KRAS_uc001rgq.1_Missense_Mutation_p.G12S|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	18					0	0	0.00499	0	0
ARNTL2	56938	broad.mit.edu	37	12	27571064	27571064	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:27571064G>T	uc001rht.1	+	16	1727	c.1709G>T	c.(1708-1710)GGG>GTG	p.G570V	ARNTL2_uc001rhw.2_Missense_Mutation_p.G533V|ARNTL2_uc010sjp.1_Intron|ARNTL2_uc001rhu.1_Missense_Mutation_p.G556V|ARNTL2_uc009zji.1_Missense_Mutation_p.G536V|ARNTL2_uc001rhv.1_Missense_Mutation_p.G522V|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	570					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TCTGAAATGGGGGAGCTAGAG	0.458			NA											13	96					3.41278e-10	4.4544e-10	0.00499	1	0
C12orf35	55196	broad.mit.edu	37	12	32140239	32140239	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:32140239A>C	uc001rks.2	+	5	5483	c.5069A>C	c.(5068-5070)AAA>ACA	p.K1690T	C12orf35_uc001rkt.2_RNA	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1690										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AGGACACAGAAAGACAGCCAA	0.299			NA											9	46					0	0	0.001368	0	0
TMEM117	84216	broad.mit.edu	37	12	44782260	44782260	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:44782260A>T	uc001rod.2	+	8	1416	c.1350A>T	c.(1348-1350)CGA>CGT	p.R450R	TMEM117_uc001roe.2_Silent_p.R346R|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	450						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GAATCACTCGAGAAAACACCC	0.423			NA											11	138					0	0	0.000978	0	0
KRT82	3888	broad.mit.edu	37	12	52797629	52797629	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:52797629C>T	uc001sai.1	-	2	591	c.476G>A	c.(475-477)AGG>AAG	p.R159K		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	159	Linker 1.|Rod.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		CTGGCAGCACCTCTGCTGCTG	0.582			NA											17	61					0	0	0.00499	0	0
KRT6A	3853	broad.mit.edu	37	12	52881579	52881579	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:52881579G>T	uc001sam.2	-	9	1829	c.1620C>A	c.(1618-1620)AGC>AGA	p.S540R		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	540	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton	p.S540I(1)		ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTCCAACAGAGCTGAGGCCAC	0.587			NA											43	53					3.54561e-26	5.51772e-26	0.009718	1	0
DNAJC14	85406	broad.mit.edu	37	12	56222188	56222188	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:56222188T>A	uc001shx.1	-	2	459	c.255A>T	c.(253-255)AGA>AGT	p.R85S	DNAJC14_uc001shu.1_Missense_Mutation_p.R85S|DNAJC14_uc009zob.1_Missense_Mutation_p.R85S|DNAJC14_uc001shy.1_Missense_Mutation_p.R85S	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	85					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCTCTGCATCTCTAGGTGGTC	0.557			NA											33	245					0	0	0.002445	0	0
R3HDM2	22864	broad.mit.edu	37	12	57662237	57662237	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:57662237G>A	uc009zpm.1	-	16	1872	c.1837C>T	c.(1837-1839)CCA>TCA	p.P613S	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.P308S|R3HDM2_uc001snr.2_Missense_Mutation_p.P340S|R3HDM2_uc001sns.2_Missense_Mutation_p.P613S|R3HDM2_uc001snt.2_Missense_Mutation_p.P627S|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	613	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						CTACCCACTGGAACCTGGGTG	0.532			NA											21	55					0	0	0.001882	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58025111	58025111	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:58025111A>C	uc001spg.1	-	3	687	c.255T>G	c.(253-255)AGT>AGG	p.S85R	B4GALNT1_uc010sru.1_Intron|B4GALNT1_uc010srv.1_Missense_Mutation_p.S85R|B4GALNT1_uc001sph.2_Missense_Mutation_p.S85R|B4GALNT1_uc001spi.2_Missense_Mutation_p.S85R|B4GALNT1_uc010srw.1_Missense_Mutation_p.S162R	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	85	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGCCCCCCCCACTGGACTCAC	0.582			NA											19	113					0	0	0.003954	0	0
TBC1D15	64786	broad.mit.edu	37	12	72233547	72233547	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:72233547G>T	uc001swu.2	+	1	61	c.52G>T	c.(52-54)GCA>TCA	p.A18S	TBC1D15_uc009zrv.2_5'UTR|TBC1D15_uc010stt.1_5'UTR|TBC1D15_uc001swv.2_Missense_Mutation_p.A18S|TBC1D15_uc001sww.2_5'UTR	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	Error:Variant_position_missing_in_Q8TC07_after_alignment							protein binding|Rab GTPase activator activity				0						TCATTACCAGGCACGCGCAGG	0.582			NA											10	38					6.40141e-05	7.16413e-05	0.000978	1	0
NAV3	89795	broad.mit.edu	37	12	78225320	78225320	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:78225320C>A	uc001syp.2	+	1	252	c.79C>A	c.(79-81)CCA>ACA	p.P27T	NAV3_uc001syo.2_Missense_Mutation_p.P27T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	27						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCTTCCGATACCAAATCTTGG	0.458			NA								HNSCC(70;0.22)			75	143					2.10328e-26	3.28287e-26	0.00361	1	0
NAV3	89795	broad.mit.edu	37	12	78443862	78443862	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:78443862G>A	uc001syp.2	+	10	2286	c.2113G>A	c.(2113-2115)GGG>AGG	p.G705R	NAV3_uc001syo.2_Missense_Mutation_p.G705R|NAV3_uc010sub.1_Missense_Mutation_p.G205R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	705	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAGTCTTCGTGGGACTCAGAT	0.333			NA								HNSCC(70;0.22)			6	41					0	0	0.001984	0	0
RASSF9	9182	broad.mit.edu	37	12	86199740	86199740	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:86199740T>C	uc001taf.1	-	2	387	c.48A>G	c.(46-48)AGA>AGG	p.R16R		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	16					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TAGTTGGAGATCTGAAAGAAA	0.378			NA											11	45					0	0	0.008291	0	0
APAF1	317	broad.mit.edu	37	12	99093342	99093342	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:99093342A>G	uc001tfz.2	+	17	3038	c.2461A>G	c.(2461-2463)ATC>GTC	p.I821V	APAF1_uc001tfy.2_Missense_Mutation_p.I810V|APAF1_uc001tga.2_Missense_Mutation_p.I810V|APAF1_uc001tgb.2_Missense_Mutation_p.I821V|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.I230V	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	821	WD 5.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	AAAAAATAAAATCTTTGTAAG	0.328			NA											7	51					0	0	0.004482	0	0
ACACB	32	broad.mit.edu	37	12	109612000	109612000	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:109612000C>T	uc001tob.2	+	7	1300	c.1181C>T	c.(1180-1182)ACG>ATG	p.T394M	ACACB_uc001toc.2_Missense_Mutation_p.T394M	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	394	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GTCGCCCAGACGCTACAGGTC	0.602			NA											4	19					0	0	0.000602	0	0
RBM19	9904	broad.mit.edu	37	12	114386709	114386710	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:114386709_114386710CC>AA	uc009zwi.2	-	10	1348_1349	c.1204_1205GG>TT	c.(1204-1206)GGA>TTA	p.G402L	RBM19_uc001tvn.3_Missense_Mutation_p.G402L|RBM19_uc001tvm.2_Missense_Mutation_p.G402L	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	402	RRM 3.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					AAAGAGCCTTCCGGATTCGGCC	0.584			NA											15	106					0	0	0.004672	0	0
ANAPC5	51433	broad.mit.edu	37	12	121766294	121766294	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:121766294C>G	uc001uag.2	-	10	1251	c.1129G>C	c.(1129-1131)GCC>CCC	p.A377P	ANAPC5_uc010szu.1_Missense_Mutation_p.A43P|ANAPC5_uc001uae.2_5'UTR|ANAPC5_uc010szv.1_5'UTR|ANAPC5_uc001uaf.2_RNA|ANAPC5_uc001uah.2_Intron|ANAPC5_uc001uai.1_Intron	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	377					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCAGGGAGGCGAGGTACTAA	0.478			NA											6	41					0	0	0.00308	0	0
KNTC1	9735	broad.mit.edu	37	12	123032049	123032049	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:123032049G>A	uc001ucv.2	+	11	1067	c.904G>A	c.(904-906)GAA>AAA	p.E302K	KNTC1_uc010taf.1_Missense_Mutation_p.E265K	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	302					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TCTTACTACAGAAGCAGACTC	0.428			NA											7	15					0	0	0.001984	0	0
DDX55	57696	broad.mit.edu	37	12	124097728	124097728	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:124097728A>T	uc001ufi.2	+	8	777	c.753A>T	c.(751-753)GCA>GCT	p.A251A	DDX55_uc001ufh.2_Silent_p.A104A|DDX55_uc001ufj.1_Silent_p.A104A|DDX55_uc001ufk.2_Silent_p.A104A	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	251							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TATGCAAGGCAGATGAGAAAT	0.378			NA											9	64					0	0	0.004482	0	0
RIMBP2	23504	broad.mit.edu	37	12	130912804	130912804	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:130912804C>T	uc001uil.2	-	12	2445	c.2281G>A	c.(2281-2283)GAG>AAG	p.E761K		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	761						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		AGCTCCTCCTCGTCCTCCTCC	0.617			NA											13	73					0	0	0.00245	0	0
PUS1	80324	broad.mit.edu	37	12	132416843	132416843	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:132416843G>T	uc001ujf.2	+	3	906	c.427G>T	c.(427-429)GCC>TCC	p.A143S	PUS1_uc001ujg.2_Missense_Mutation_p.A115S|PUS1_uc001ujh.2_Missense_Mutation_p.A115S|PUS1_uc001uji.2_Missense_Mutation_p.A90S	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	143						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCAGCGCTGCGCCCGGACAGA	0.562	Esophageal Squamous(102;671 2009 17384 45666)		NA											12	24					2.27111e-07	2.73365e-07	0.001368	1	0
SLC7A1	6541	broad.mit.edu	37	13	30091719	30091719	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:30091719T>A	uc001uso.2	-	10	1888	c.1501A>T	c.(1501-1503)AGC>TGC	p.S501C		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	501	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CCTATGAGGCTGGTTGAAATG	0.488			NA											34	108					0	0	0.004289	0	0
LRCH1	23143	broad.mit.edu	37	13	47315804	47315804	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:47315804C>G	uc001vbj.2	+	19	2244	c.2008C>G	c.(2008-2010)CTG>GTG	p.L670V	LRCH1_uc001vbk.2_Missense_Mutation_p.L705V|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	670	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GTGTGACATCCTGCAGTTGGA	0.517			NA											112	382					0	0	0.00361	0	0
CKAP2	26586	broad.mit.edu	37	13	53049190	53049190	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:53049190A>T	uc001vgv.2	+	9	2163	c.1966A>T	c.(1966-1968)ACG>TCG	p.T656S	CKAP2_uc001vgu.2_Missense_Mutation_p.T655S|CKAP2_uc010tha.1_Missense_Mutation_p.T607S	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	656					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		GGAACAGCTAACGGAGTTGGG	0.423			NA											40	98					0	0	0.00623	0	0
OLFM4	10562	broad.mit.edu	37	13	53617317	53617317	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:53617317C>A	uc001vhl.2	+	4	648	c.648C>A	c.(646-648)ATC>ATA	p.I216I	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	216	Potential.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GCCGAGAAATCGTGGCTCTGA	0.443			NA											28	69					2.61193e-14	3.67347e-14	0.009535	1	0
SLC10A2	6555	broad.mit.edu	37	13	103718589	103718589	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:103718589G>T	uc001vpy.3	-	1	608	c.11C>A	c.(10-12)CCG>CAG	p.P4Q		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	4	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACAGCTGTTCGGATCATTCAT	0.517			NA											11	34					1.5842e-08	1.96995e-08	0.001855	1	0
OR4K17	390436	broad.mit.edu	37	14	20585973	20585973	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:20585973C>G	uc001vwo.1	+	1	408	c.408C>G	c.(406-408)CAC>CAG	p.H136Q		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTCTCCTTCACTTACTGGGTG	0.433			NA											21	132					0	0	0.008871	0	0
OR4N5	390437	broad.mit.edu	37	14	20612644	20612644	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:20612644G>T	uc010tla.1	+	1	750	c.750G>T	c.(748-750)ATG>ATT	p.M250I		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TATTTCTCATGTTTGGACCTG	0.438			NA											93	225					1.50986e-39	2.46642e-39	0.00361	1	0
OR10G3	26533	broad.mit.edu	37	14	22037988	22037988	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:22037988C>T	uc010tmb.1	-	1	888	c.888G>A	c.(886-888)GTG>GTA	p.V296V		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GGGCCAGCTTCACCTCTTGGT	0.522			NA											6	56					0	0	0.001168	0	0
CTAGE5	4253	broad.mit.edu	37	14	39815112	39815112	+	Silent	SNP	A	A	G	rs146750332		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:39815112A>G	uc001wvg.3	+	21	2172	c.1836A>G	c.(1834-1836)CAA>CAG	p.Q612Q	CTAGE5_uc010tqe.1_Silent_p.Q574Q|CTAGE5_uc001wuz.3_Silent_p.Q600Q|CTAGE5_uc001wuy.3_Silent_p.Q532Q|CTAGE5_uc001wvb.3_Silent_p.Q540Q|CTAGE5_uc001wvc.3_Silent_p.Q514Q|CTAGE5_uc001wva.3_Silent_p.Q583Q|CTAGE5_uc001wvh.3_Silent_p.Q569Q|CTAGE5_uc001wvf.3_Silent_p.Q537Q|CTAGE5_uc001wvi.3_Silent_p.Q617Q|CTAGE5_uc010amz.2_Silent_p.Q228Q|CTAGE5_uc001wvj.3_Silent_p.Q583Q	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	612	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TTCTAGGACAATCATATCCTG	0.328			NA											6	44					0	0	0.001168	0	0
FRMD6	122786	broad.mit.edu	37	14	52186968	52186968	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:52186968G>T	uc001wzd.2	+	11	1505	c.1220G>T	c.(1219-1221)GGG>GTG	p.G407V	FRMD6_uc001wzb.2_Missense_Mutation_p.G399V|FRMD6_uc001wzc.2_Missense_Mutation_p.G399V|FRMD6_uc001wze.2_Missense_Mutation_p.G330V|FRMD6_uc001wzf.2_Missense_Mutation_p.G100V|FRMD6_uc001wzg.2_Missense_Mutation_p.G49V	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	407						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					CGGGACACGGGGCCAGAAGAC	0.612			NA											17	75					6.94344e-10	8.97359e-10	0.006122	1	0
C14orf37	145407	broad.mit.edu	37	14	58471883	58471883	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:58471883C>A	uc001xdc.2	-	7	2250	c.2139G>T	c.(2137-2139)GGG>GGT	p.G713G	C14orf37_uc010tro.1_Silent_p.G751G|C14orf37_uc001xdd.2_Silent_p.G713G	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	713	Extracellular (Potential).					integral to membrane	binding				0						GCACCAGCATCCCAGACATGT	0.517			NA											12	76					2.61681e-11	3.5024e-11	0.00245	1	0
SLC8A3	6547	broad.mit.edu	37	14	70634104	70634104	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:70634104G>T	uc001xly.2	-	2	1790	c.1036C>A	c.(1036-1038)CAC>AAC	p.H346N	SLC8A3_uc001xlw.2_Missense_Mutation_p.H346N|SLC8A3_uc001xlx.2_Missense_Mutation_p.H346N|SLC8A3_uc001xlz.2_Missense_Mutation_p.H346N|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	346	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTCTGTTGGTGGGAAAGAGCA	0.488			NA											19	74					6.49762e-13	8.94698e-13	0.006122	1	0
MOAP1	64112	broad.mit.edu	37	14	93649946	93649946	+	Silent	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:93649946T>G	uc001ybj.2	-	3	1012	c.642A>C	c.(640-642)GCA>GCC	p.A214A	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	214					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		taacatcaagtgctgggcctc	0			NA											19	125					0	0	0.008871	0	0
SERPINA3	12	broad.mit.edu	37	14	95081052	95081052	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:95081052C>T	uc001ydp.2	+	2	353	c.274C>T	c.(274-276)CAT>TAT	p.H92Y	SERPINA3_uc001ydo.3_Missense_Mutation_p.H117Y|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.H92Y|SERPINA3_uc001yds.2_Missense_Mutation_p.H92Y|SERPINA3_uc010avg.2_Missense_Mutation_p.H92Y	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	92					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TCTGGGGGCCCATAATACCAC	0.542			NA											18	102					0	0	0.007413	0	0
C14orf177	283598	broad.mit.edu	37	14	99182651	99182651	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:99182651C>G	uc001yfz.1	+	3	542	c.123C>G	c.(121-123)TGC>TGG	p.C41W		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	41											0		Melanoma(154;0.128)				AAGGGAAATGCCCAAGTTCTC	0.542			NA											5	38					0	0	0.001168	0	0
DLK1	8788	broad.mit.edu	37	14	101200875	101200875	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:101200875C>T	uc001yhs.3	+	5	947	c.794C>T	c.(793-795)GCC>GTC	p.A265V	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	265	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				TATGGGCTGGCCTACCGCCTG	0.637			NA											19	47					0	0	0.006122	0	0
RAGE	5891	broad.mit.edu	37	14	102717268	102717268	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:102717268C>A	uc001ylm.2	-	7	697	c.471G>T	c.(469-471)CCG>CCT	p.P157P	RAGE_uc010txv.1_Silent_p.P127P|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	157	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ATTCCGTGTACGGCTGCTTGG	0.552			NA											19	124					2.89027e-11	3.83909e-11	0.002299	1	0
AHNAK2	113146	broad.mit.edu	37	14	105412058	105412058	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:105412058G>C	uc010axc.1	-	7	9850	c.9730C>G	c.(9730-9732)CCC>GCC	p.P3244A	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3144A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3244						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTATCTGGGGGCCCTTGCGA	0.612			NA											91	145					0	0	0.00361	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420887	105420887	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:105420887C>T	uc010axc.1	-	7	1021	c.901G>A	c.(901-903)GAG>AAG	p.E301K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E201K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	301						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGCTGGGCCTCTGTGTCTGTG	0.632			NA											9	11					0	0	0.008291	0	0
PACS2	23241	broad.mit.edu	37	14	105814896	105814896	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:105814896G>T	uc001yqt.2	+	2	361	c.186G>T	c.(184-186)GTG>GTT	p.V62V	PACS2_uc001yqs.2_5'UTR|PACS2_uc001yqv.2_Silent_p.V62V|PACS2_uc001yqu.2_Silent_p.V62V	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	62					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		TGATCTCCGTGGTGATCGCTG	0.612			NA											23	74					2.89027e-11	3.83909e-11	0.002299	1	0
DISP2	85455	broad.mit.edu	37	15	40659393	40659393	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:40659393C>T	uc001zlk.1	+	8	1169	c.1080C>T	c.(1078-1080)GAC>GAT	p.D360D		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	360					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCCAAGCTGACGCAGCCCGCA	0.642			NA											20	91					0	0	0.008871	0	0
LTK	4058	broad.mit.edu	37	15	41796779	41796779	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:41796779C>T	uc001zoa.3	-	18	2358	c.2180G>A	c.(2179-2181)CGC>CAC	p.R727H	LTK_uc001zob.3_Missense_Mutation_p.R666H|LTK_uc010ucx.1_Missense_Mutation_p.R597H|LTK_uc010bcg.2_Missense_Mutation_p.R425H	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	727	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CTGGTTGGTGCGCCCAGGATA	0.627			NA								TSP Lung(18;0.14)			23	89					0	0	0.001882	0	0
UNC13C	440279	broad.mit.edu	37	15	54305743	54305743	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:54305743G>T	uc002ack.2	+	1	643	c.643G>T	c.(643-645)GAC>TAC	p.D215Y		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	215					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TAAGTCTTTGGACAGAACTGT	0.423			NA											50	57					9.90819e-18	1.4397e-17	0.00361	1	0
CGNL1	84952	broad.mit.edu	37	15	57734609	57734609	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:57734609A>G	uc002aeg.2	+	4	1812	c.1736A>G	c.(1735-1737)AAC>AGC	p.N579S	CGNL1_uc010bfw.2_Missense_Mutation_p.N579S	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	579						myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGGAAAGTCAACTTGGTCTTT	0.408			NA											16	47					0	0	0.004007	0	0
DENND4A	10260	broad.mit.edu	37	15	66034066	66034066	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:66034066T>C	uc002aph.2	-	5	996	c.618A>G	c.(616-618)GTA>GTG	p.V206V	DENND4A_uc002api.2_Silent_p.V206V|DENND4A_uc002apj.3_Silent_p.V206V|DENND4A_uc010ujj.1_Silent_p.V206V	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	206	UDENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CTTTGTAAGATACAGTGTTCG	0.214			NA											8	43					0	0	0.00308	0	0
LARP6	55323	broad.mit.edu	37	15	71124472	71124472	+	Silent	SNP	G	G	T	rs150993636		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:71124472G>T	uc002ass.2	-	3	1466	c.1395C>A	c.(1393-1395)CCC>CCA	p.P465P		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	465					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						GCACCCCTACGGGTAGCCCAT	0.577			NA											33	98					1.06647e-15	1.51612e-15	0.003755	1	0
TMC3	342125	broad.mit.edu	37	15	81624961	81624961	+	Missense_Mutation	SNP	G	G	T	rs115607037	by1000genomes	TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:81624961G>T	uc002bgo.1	-	22	3102	c.3102C>A	c.(3100-3102)TTC>TTA	p.F1034L	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	1034	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						GGGATGGCTCGAACCTGGGCT	0.607			NA											12	22					2.68362e-12	3.676e-12	0.001368	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84659957	84659957	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:84659957C>A	uc002bjz.3	+	23	4188	c.3964C>A	c.(3964-3966)CCT>ACT	p.P1322T	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.P1322T|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.P1322T	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1322	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATCCGATGTCCTGTAAAAGG	0.502			NA											106	106					1.48543e-65	2.45703e-65	0.00361	1	0
NTRK3	4916	broad.mit.edu	37	15	88669511	88669511	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:88669511C>A	uc002bme.1	-	12	1549	c.1387G>T	c.(1387-1389)GGA>TGA	p.G463*	NTRK3_uc002bmh.2_Nonsense_Mutation_p.G455*|NTRK3_uc002bmf.1_Nonsense_Mutation_p.G463*|NTRK3_uc010upl.1_Nonsense_Mutation_p.G365*|NTRK3_uc010bnh.1_Nonsense_Mutation_p.G455*|NTRK3_uc002bmg.2_Nonsense_Mutation_p.G463*	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	463	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCCTTCATTCCAAATTTGGAC	0.443			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			11	31					5.50884e-06	6.35449e-06	0.001368	1	0
UNC45A	55898	broad.mit.edu	37	15	91490084	91490084	+	Silent	SNP	G	G	T	rs146865609		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr15:91490084G>T	uc002bqg.2	+	10	1780	c.1440G>T	c.(1438-1440)TCG>TCT	p.S480S	UNC45A_uc002bqd.2_Silent_p.S465S|UNC45A_uc010uqr.1_5'Flank|UNC45A_uc002bqi.2_5'Flank	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	480					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ATGGTGTCTCGCTGCTGAAGG	0.632			NA											62	43					3.07184e-27	4.80889e-27	0.00361	1	0
RGS11	8786	broad.mit.edu	37	16	321439	321439	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:321439C>A	uc002cgj.1	-	11	711	c.708G>T	c.(706-708)GCG>GCT	p.A236A	RGS11_uc002cgi.1_Silent_p.A215A|RGS11_uc010bqs.1_Silent_p.A225A|RGS11_uc002cgk.1_Silent_p.A52A	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	236	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				TCCTGCCCAGCGCTTTCCTGA	0.647			NA											14	45					2.23348e-06	2.61069e-06	0.004007	1	0
RPL3L	6123	broad.mit.edu	37	16	1994846	1994846	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:1994846C>A	uc002cnh.2	-	10	1263	c.1216G>T	c.(1216-1218)GAC>TAC	p.D406Y	SEPX1_uc010uvs.1_5'Flank	NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	406					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						GCCTACAAGTCTCCCGAGGTC	0.592			NA											46	150					3.19069e-20	4.75439e-20	0.00361	1	0
PPL	5493	broad.mit.edu	37	16	4941886	4941886	+	Nonsense_Mutation	SNP	C	C	A	rs139811413		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:4941886C>A	uc002cyd.1	-	16	1984	c.1894G>T	c.(1894-1896)GAG>TAG	p.E632*		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	632	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						AGATGGTTCTCGTGTGTGGCC	0.622			NA											6	137					0.00198382	0.00211661	0.001984	1	0
A2BP1	54715	broad.mit.edu	37	16	7680687	7680687	+	Splice_Site	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:7680687T>A	uc002cys.2	+	11	1745	c.757_splice	c.e11+2	p.M253_splice	A2BP1_uc010buf.1_Splice_Site_p.M253_splice|A2BP1_uc002cyr.1_Splice_Site_p.M252_splice|A2BP1_uc002cyt.2_Intron|A2BP1_uc010uxz.1_Splice_Site_p.M296_splice|A2BP1_uc010uya.1_Splice_Site_p.M210_splice|A2BP1_uc002cyv.1_Splice_Site_p.M253_splice|A2BP1_uc010uyb.1_Splice_Site_p.M253_splice|A2BP1_uc002cyw.2_Splice_Site_p.M273_splice|A2BP1_uc002cyy.2_Splice_Site_p.M273_splice|A2BP1_uc002cyx.2_Splice_Site_p.M273_splice|A2BP1_uc010uyc.1_Intron	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4						mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		CTTCTGCAAGTAAGCCCACTG	0.517			NA											6	38					0	0	0.001168	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858403	9858403	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:9858403C>T	uc002czo.3	-	13	3546	c.2998G>A	c.(2998-3000)GTG>ATG	p.V1000M	GRIN2A_uc010uym.1_Missense_Mutation_p.V1000M|GRIN2A_uc010uyn.1_Missense_Mutation_p.V843M|GRIN2A_uc002czr.3_Missense_Mutation_p.V1000M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1000	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTGTGCTCACGGCCACCTCC	0.512			NA											17	77					0	0	0.004007	0	0
PARN	5073	broad.mit.edu	37	16	14540779	14540779	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:14540779T>A	uc010uzd.1	-	23	1972	c.1830A>T	c.(1828-1830)AAA>AAT	p.K610N	PARN_uc010uzc.1_Missense_Mutation_p.K549N|PARN_uc010uze.1_Missense_Mutation_p.K564N|PARN_uc010uzf.1_Missense_Mutation_p.K435N	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	610					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						TTCTTTTTAATTTCTTGGCCT	0.488			NA											17	73					0	0	0.007413	0	0
XYLT1	64131	broad.mit.edu	37	16	17228333	17228333	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:17228333C>G	uc002dfa.2	-	9	2109	c.2024G>C	c.(2023-2025)TGC>TCC	p.C675S		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	675	Lumenal (Potential).			C->A: No effect.	glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GGCTCACCGGCAGCTGTTCTC	0.607			NA											16	62					0	0	0.004007	0	0
SMG1	23049	broad.mit.edu	37	16	18847769	18847769	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:18847769T>C	uc002dfm.2	-	47	8053	c.7690A>G	c.(7690-7692)ATA>GTA	p.I2564V	SMG1_uc010bwb.2_Missense_Mutation_p.I2424V|SMG1_uc010bwa.2_Missense_Mutation_p.I1295V	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2564					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TAATGTGTTATCCATTGTTCA	0.428			NA											20	57					0	0	0.008871	0	0
GP2	2813	broad.mit.edu	37	16	20335184	20335184	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:20335184C>A	uc002dgv.2	-	3	572	c.489G>T	c.(487-489)GTG>GTT	p.V163V	GP2_uc002dgw.2_Silent_p.V163V|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	163						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CCAACCGGTACACATGGTACC	0.572			NA											4	16					0.00909568	0.00956866	0.009096	1	0
DNAH3	55567	broad.mit.edu	37	16	20974768	20974768	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:20974768G>A	uc010vbe.1	-	53	10438	c.10438C>T	c.(10438-10440)CGG>TGG	p.R3480W	DNAH3_uc010vbd.1_Missense_Mutation_p.R915W	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3480					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGTCAGGCCGCAAACATCGA	0.522			NA											7	49					0	0	0.001984	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24931498	24931498	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:24931498G>C	uc002dnb.2	-	20	2692	c.2599C>G	c.(2599-2601)CGC>GGC	p.R867G	ARHGAP17_uc002dmx.2_3'UTR|ARHGAP17_uc002dmw.2_3'UTR|ARHGAP17_uc002dmy.2_Missense_Mutation_p.R312G|ARHGAP17_uc002dmz.2_Missense_Mutation_p.R391G|ARHGAP17_uc002dna.2_Missense_Mutation_p.R594G|ARHGAP17_uc002dnc.2_Missense_Mutation_p.R789G|ARHGAP17_uc010vcf.1_Missense_Mutation_p.R610G|ARHGAP17_uc002dnd.1_RNA|ARHGAP17_uc002dne.1_Silent_p.A124A	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	867					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		AGCAGGATGCGGCCAGGCACG	0.552			NA											26	70					0	0	0.004656	0	0
SMPD3	55512	broad.mit.edu	37	16	68404942	68404942	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:68404942G>C	uc002ewa.2	-	3	1565	c.1143C>G	c.(1141-1143)TAC>TAG	p.Y381*	SMPD3_uc010cfe.2_Nonsense_Mutation_p.Y381*|SMPD3_uc010vlh.1_Nonsense_Mutation_p.Y381*	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	381	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	TGTACTCGAAGTAGCCGTGCA	0.597			NA											8	42					0	0	0.00308	0	0
PHLPP2	23035	broad.mit.edu	37	16	71703215	71703215	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:71703215C>G	uc002fax.2	-	10	1597	c.1591G>C	c.(1591-1593)GAT>CAT	p.D531H	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.D531H	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	531	LRR 13.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TAGCTCACATCTAATACTTCT	0.378			NA											22	69					0	0	0.002299	0	0
WWOX	51741	broad.mit.edu	37	16	78198109	78198109	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:78198109C>T	uc002ffk.2	+	5	564	c.439C>T	c.(439-441)CAT>TAT	p.H147Y	WWOX_uc010vnk.1_Missense_Mutation_p.H34Y|WWOX_uc002ffl.2_Missense_Mutation_p.H147Y|WWOX_uc010che.2_Intron|WWOX_uc002ffj.1_Missense_Mutation_p.H147Y	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	147	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTTTGCCCTCCATGGTGCACA	0.443			NA											23	27					0	0	0.00278	0	0
ACSF3	197322	broad.mit.edu	37	16	89167225	89167225	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr16:89167225G>T	uc002fmp.2	+	3	476	c.136G>T	c.(136-138)GTG>TTG	p.V46L	ACSF3_uc010cig.1_Missense_Mutation_p.V46L|ACSF3_uc010cih.1_Intron|ACSF3_uc002fmq.1_RNA|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_5'Flank	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	46					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GAGCGCCCCGGTGTTCACCCG	0.677			NA											25	21					4.47668e-21	6.72781e-21	0.003954	1	0
OR1A2	26189	broad.mit.edu	37	17	3101695	3101695	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:3101695A>T	uc002fvd.1	+	1	883	c.883A>T	c.(883-885)ATG>TTG	p.M295L		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AAATTGGGATATGAAGGCAGC	0.453			NA											67	70					0	0	0.00361	0	0
TP53	7157	broad.mit.edu	37	17	7576897	7576897	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:7576897G>A	uc002gim.2	-	9	1143	c.949C>T	c.(949-951)CAG>TAG	p.Q317*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q317*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q185*|TP53_uc010cng.1_Nonsense_Mutation_p.Q185*|TP53_uc002gii.1_Nonsense_Mutation_p.Q185*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q317*|TP53_uc010cni.1_Nonsense_Mutation_p.Q317*|TP53_uc002gij.2_Nonsense_Mutation_p.Q317*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	317	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		Q -> H (in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation).|Q -> P (in a sporadic cancer; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q317*(19)|p.0?(7)|p.Q317K(3)|p.Q317R(2)|p.S315fs*22(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)|p.Q317P(1)|p.Q317fs*28(1)|p.Q317fs*45(1)|p.Q317fs*19(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTTTGGCTGGGGAGAGGAG	0.473	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	40					0	0	0.002096	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8219340	8219340	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:8219340C>T	uc002glc.2	+	9	1699	c.1578C>T	c.(1576-1578)GAC>GAT	p.D526D	ARHGEF15_uc002gld.2_Silent_p.D526D|ARHGEF15_uc010vuw.1_Silent_p.D415D	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	526	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCTGCAGGGACACCAACGTGC	0.687			NA											8	19					0	0	0.00308	0	0
MYH2	4620	broad.mit.edu	37	17	10441133	10441133	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:10441133A>C	uc010coi.2	-	15	1564	c.1436T>G	c.(1435-1437)CTG>CGG	p.L479R	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.L479R|MYH2_uc010coj.2_Missense_Mutation_p.L479R	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	479	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GTTGATGCACAGCTGCTCCAG	0.378			NA											7	142					0	0	0.006214	0	0
COX10	1352	broad.mit.edu	37	17	14005480	14005480	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:14005480G>T	uc002gof.3	+	4	749	c.545G>T	c.(544-546)GGC>GTC	p.G182V	COX10_uc010vvs.1_5'UTR|COX10_uc010vvt.1_Intron	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	182	Helical; (Potential).				heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		TTGGCTCCGGGCCCTTTTGAC	0.502			NA											7	119					8.12818e-05	9.03895e-05	0.001984	1	0
MAP2K3	5606	broad.mit.edu	37	17	21201776	21201777	+	Missense_Mutation	DNP	CC	CC	GG	rs145057136		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:21201776_21201777CC>GG	uc002gys.2	+	2	366_367	c.101_102CC>GG	c.(100-102)CCC>CGG	p.P34R	MAP2K3_uc002gyt.2_Missense_Mutation_p.P5R|MAP2K3_uc002gyu.2_Missense_Mutation_p.P5R	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	34					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TCCAAGCCACCCGCACCCAACC	0.564			NA											24	146					0	0	0.004672	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26667374	26667374	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:26667374C>A	uc002hax.1	+	3	264	c.245C>A	c.(244-246)ACC>AAC	p.T82N	TNFAIP1_uc002hay.2_Missense_Mutation_p.T82N|TNFAIP1_uc010waf.1_5'UTR	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	82	BTB.				apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CACTTTGGCACCATTTTGAAT	0.522			NA											34	103					2.09667e-21	3.17823e-21	0.003755	1	0
NEK8	284086	broad.mit.edu	37	17	27061972	27061972	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:27061972G>A	uc002hcp.2	+	3	436	c.436G>A	c.(436-438)GGT>AGT	p.G146S		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	146	Protein kinase.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					CGTCAAGATCGGTGATTTCGG	0.562	NSCLC(6;19 293 14866 25253 49845)		NA											19	146					0	0	0.007413	0	0
EVI2B	2124	broad.mit.edu	37	17	29631427	29631427	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:29631427G>A	uc002hgk.2	-	2	1356	c.1201C>T	c.(1201-1203)CTT>TTT	p.L401F	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.L416F	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	401	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GGCAAGTTAAGTGAGTCAAGC	0.418			NA											40	88					0	0	0.005524	0	0
CCL18	6362	broad.mit.edu	37	17	34391718	34391718	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:34391718G>T	uc002hku.2	+	1	76	c.16G>T	c.(16-18)GCT>TCT	p.A6S		NM_002988	NP_002979	P55774	CCL18_HUMAN	small inducible cytokine A18 precursor	6					cell-cell signaling|chemotaxis|immune response|inflammatory response|response to biotic stimulus|signal transduction	extracellular space	chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGGCCTTGCAGCTGCCCTCCT	0.582			NA											43	142					4.44401e-20	6.60325e-20	0.002522	1	0
CRHR1	1394	broad.mit.edu	37	17	43912021	43912021	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:43912021G>T	uc010dap.2	+	14	1491	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	CRHR1_uc010wjx.1_Missense_Mutation_p.R205L|CRHR1_uc002ijp.2_Missense_Mutation_p.G234C|CRHR1_uc002ijm.2_Missense_Mutation_p.R380L|CRHR1_uc002ijn.2_Missense_Mutation_p.R340L|CRHR1_uc010dar.2_Missense_Mutation_p.R366L|CRHR1_uc010dao.2_Missense_Mutation_p.R279L|CRHR1_uc010daq.2_Missense_Mutation_p.R205L	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	409	Cytoplasmic (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		AGGTGGCACCGGTGGCAGGAC	0.657	Ovarian(110;57 1568 10207 38216 49865)		NA											17	44					2.35188e-11	3.16391e-11	0.006122	1	0
ITGB3	3690	broad.mit.edu	37	17	45361945	45361945	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:45361945C>T	uc002ilj.2	+	4	518	c.498C>T	c.(496-498)ACC>ACT	p.T166T	ITGB3_uc002ili.1_Silent_p.T166T|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	166	VWFA.|Extracellular (Potential).		T -> I (associated with neonatal thrombocytopenia; alloantigen Duv(a+); does not affect significantly the integrin function).		activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	AGCTGGCCACCCAGATGCGAA	0.532			NA											57	121					0	0	0.00361	0	0
HOXB7	3217	broad.mit.edu	37	17	46685327	46685327	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:46685327C>A	uc002inv.2	-	2	634	c.531G>T	c.(529-531)ACG>ACT	p.T177T	HOXB6_uc002ins.1_5'Flank|HOXB6_uc010dbh.1_5'Flank	NM_004502	NP_004493	P09629	HXB7_HUMAN	homeobox B7	177	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTGTCTTTCCGTGAGGCAGA	0.587			NA											43	228					2.24722e-20	3.35806e-20	0.00361	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47120823	47120823	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:47120823G>T	uc002iom.2	+	10	1445	c.1111G>T	c.(1111-1113)GCT>TCT	p.A371S	IGF2BP1_uc010dbj.2_Missense_Mutation_p.A232S	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	371	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						CCTGAACCTGGCTGCTGTAGG	0.597	Esophageal Squamous(198;1041 2123 8248 37119 38268)		NA											34	71					1.836e-18	2.69007e-18	0.003755	1	0
NGFR	4804	broad.mit.edu	37	17	47590270	47590270	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:47590270A>T	uc002ioz.3	+	6	1308	c.1183A>T	c.(1183-1185)AGC>TGC	p.S395C		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	395	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CACCCAGGACAGCGCCACACT	0.687			NA											3	28					0	0	0.004672	0	0
PPM1E	22843	broad.mit.edu	37	17	57057803	57057803	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:57057803A>G	uc002iwx.2	+	7	1806	c.1679A>G	c.(1678-1680)CAA>CGA	p.Q560R	PPM1E_uc010ddd.2_Missense_Mutation_p.Q323R	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	569					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			CCAGGGTCCCAAATCAACGTG	0.527			NA											39	66					0	0	0.005524	0	0
SMARCD2	6603	broad.mit.edu	37	17	61911557	61911557	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:61911557C>G	uc010deb.1	-	8	1370	c.1053G>C	c.(1051-1053)GAG>GAC	p.E351D	SMARCD2_uc010wpt.1_Missense_Mutation_p.E303D|SMARCD2_uc010dea.1_Missense_Mutation_p.E276D|SMARCD2_uc010dec.1_Missense_Mutation_p.E330D	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	351	SWIB.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						AGTTGATGTACTCCCGCTCGT	0.602			NA									OREG0024642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	0.009096	0	0
SCN4A	6329	broad.mit.edu	37	17	62022372	62022372	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:62022372G>C	uc002jds.1	-	20	3846	c.3769C>G	c.(3769-3771)CGG>GGG	p.R1257G		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1257	III.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CTCACCTCCCGGGAGTCCACG	0.617			NA											6	36					0	0	0.001168	0	0
MAP2K6	5608	broad.mit.edu	37	17	67532289	67532289	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:67532289C>A	uc002jij.2	+	11	1203	c.915C>A	c.(913-915)TAC>TAA	p.Y305*		NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	305	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					GGCCTACATACCCAGAGCTAA	0.318			NA											15	150					1.15088e-07	1.39164e-07	0.004007	1	0
ASPSCR1	79058	broad.mit.edu	37	17	79954652	79954652	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:79954652G>T	uc002kcx.2	+	7	960	c.863G>T	c.(862-864)GGC>GTC	p.G288V	ASPSCR1_uc002kcw.1_Missense_Mutation_p.G288V|ASPSCR1_uc002kcy.2_Missense_Mutation_p.G288V|ASPSCR1_uc002kcz.2_Missense_Mutation_p.G182V|ASPSCR1_uc002kda.2_Missense_Mutation_p.G211V|ASPSCR1_uc002kdb.1_Missense_Mutation_p.G211V	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	288							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TCCAAGTCGGGCCAGGATCCC	0.428			NA	T	TFE3	alveolar soft part sarcoma								10	156					0.00829132	0.00873995	0.008291	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14851707	14851707	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr18:14851707C>T	uc010dlo.2	+	36	3587	c.3407C>T	c.(3406-3408)ACA>ATA	p.T1136I	ANKRD30B_uc010xal.1_Missense_Mutation_p.T278I	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1221	Potential.									ovary(1)|skin(1)	2						AAACAGAAAACAGTAACAAAA	0.358			NA											9	53					0	0	0.006214	0	0
DSC2	1824	broad.mit.edu	37	18	28666625	28666625	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr18:28666625C>A	uc002kwl.3	-	7	1310	c.856G>T	c.(856-858)GGG>TGG	p.G286W	DSC2_uc002kwk.3_Missense_Mutation_p.G286W	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	286	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGCACCTGCCCAATGATGGAG	0.473			NA											38	68					1.04594e-18	1.53677e-18	0.00623	1	0
STARD6	147323	broad.mit.edu	37	18	51858176	51858176	+	Silent	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr18:51858176G>C	uc010xdt.1	-	4	321	c.321C>G	c.(319-321)TCC>TCG	p.S107S		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	107	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		AGTCTCGAGGGGAAATGGAGC	0.368			NA											19	31					0	0	0.008871	0	0
SERPINB11	89778	broad.mit.edu	37	18	61379925	61379925	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr18:61379925C>T	uc002ljk.3	+	5	417	c.355C>T	c.(355-357)CAG>TAG	p.Q119*	SERPINB11_uc010xes.1_5'UTR|SERPINB11_uc010dqd.2_Nonsense_Mutation_p.Q5*|SERPINB11_uc002ljj.3_Nonsense_Mutation_p.Q5*|SERPINB11_uc010dqe.2_Nonsense_Mutation_p.Q5*|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	119					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GGCATTTCATCAGGTAAGTCC	0.433	Ovarian(27;496 784 5942 8975 23930)		NA											6	63					0	0	0.001168	0	0
AMH	268	broad.mit.edu	37	19	2251711	2251711	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:2251711C>T	uc002lvh.2	+	5	1657	c.1438C>T	c.(1438-1440)CCC>TCC	p.P480S		NM_000479	NP_000470	P03971	MIS_HUMAN	anti-Mullerian hormone precursor	480					cell differentiation|cell-cell signaling|gonadal mesoderm development|Mullerian duct regression|positive regulation of gene expression|sex determination	extracellular space	growth factor activity|hormone activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTACTCATCCCCGAGACCTA	0.716			NA							Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				6	27					0	0	0.006214	0	0
C19orf29	58509	broad.mit.edu	37	19	3623819	3623819	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:3623819C>A	uc002lyh.2	-	2	562	c.509G>T	c.(508-510)CGG>CTG	p.R170L	C19orf29_uc010dtn.2_5'Flank|C19orf29_uc002lyi.3_Missense_Mutation_p.R170L|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	170	Potential.					catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGGCCAGCCGCCGTGCGCG	0.657			NA											8	25					0.000157383	0.000174281	0.00308	1	0
MATK	4145	broad.mit.edu	37	19	3779703	3779703	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:3779703C>A	uc002lyt.2	-	9	1235	c.835G>T	c.(835-837)GTC>TTC	p.V279F	MATK_uc002lyv.2_Missense_Mutation_p.V280F|MATK_uc002lyu.2_Missense_Mutation_p.V238F|MATK_uc010dtq.2_Missense_Mutation_p.V279F	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	279	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGTCATGACGGCCGTCTCG	0.667			NA											14	41					3.27435e-08	4.03351e-08	0.00245	1	0
ZNF560	147741	broad.mit.edu	37	19	9578992	9578992	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:9578992C>T	uc002mlp.1	-	10	841	c.631G>A	c.(631-633)GAG>AAG	p.E211K	ZNF560_uc010dwr.1_Missense_Mutation_p.E105K	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TAGAGTTCCTCTCCATTTTGG	0.363			NA											15	48					0	0	0.003163	0	0
OR7A17	26333	broad.mit.edu	37	19	14991763	14991763	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:14991763G>A	uc010xob.1	-	1	405	c.405C>T	c.(403-405)ATC>ATT	p.I135I		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GAGGGTTCATGATGACTGTGT	0.488			NA											39	43					0	0	0.004878	0	0
ZNF536	9745	broad.mit.edu	37	19	31025799	31025799	+	Missense_Mutation	SNP	C	C	G	rs144474545		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:31025799C>G	uc002nsu.1	+	3	2354	c.2216C>G	c.(2215-2217)GCG>GGG	p.A739G	ZNF536_uc010edd.1_Missense_Mutation_p.A739G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	739					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.A739A(1)		ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGCAACCAGCGCTGCTTCGC	0.567			NA											26	168					0	0	0.00333	0	0
ZNF536	9745	broad.mit.edu	37	19	31040344	31040344	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:31040344C>T	uc002nsu.1	+	4	3956	c.3818C>T	c.(3817-3819)TCT>TTT	p.S1273F	ZNF536_uc010edd.1_Missense_Mutation_p.S1273F	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCTACAGTTCTGATGGCTTA	0.557			NA											11	50					0	0	0.001855	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767742	31767742	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:31767742C>G	uc002nsy.3	-	2	3022	c.2957G>C	c.(2956-2958)AGG>ACG	p.R986T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	986	C2H2-type 4.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGAAGGAGTCCTGATTTGGGA	0.483			NA											17	67					0	0	0.008871	0	0
ZNF567	163081	broad.mit.edu	37	19	37210634	37210634	+	Silent	SNP	G	G	T	rs117657033	by1000genomes	TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:37210634G>T	uc010xtl.1	+	6	1230	c.1008G>T	c.(1006-1008)TCG>TCT	p.S336S	ZNF567_uc002oeo.1_Silent_p.S336S|ZNF567_uc010xtk.1_Silent_p.S336S|ZNF567_uc002oep.3_Silent_p.S305S|ZNF567_uc002oeq.1_Silent_p.S305S	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GGGAGAAATCGTATGAATGTC	0.453			NA											8	63					0.000274275	0.000299935	0.004482	1	0
FCGBP	8857	broad.mit.edu	37	19	40433095	40433095	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:40433095A>T	uc002omp.3	-	2	1182	c.1174T>A	c.(1174-1176)TCG>ACG	p.S392T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	392	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGCATACGAGAACTCACTG	0.612			NA											5	47					0	0	0.000602	0	0
CYP2A13	1553	broad.mit.edu	37	19	41599626	41599626	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:41599626C>A	uc002opt.2	+	6	932	c.923C>A	c.(922-924)ACC>AAC	p.T308N		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	308					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	ACCGTGAGCACCACCCTGCGC	0.562			NA											12	78					7.03913e-09	8.83671e-09	0.001368	1	0
ATP1A3	478	broad.mit.edu	37	19	42492646	42492646	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:42492646G>T	uc002osg.2	-	2	229	c.75C>A	c.(73-75)CTC>CTA	p.L25L	ATP1A3_uc010xwf.1_Silent_p.L36L|ATP1A3_uc010xwg.1_5'UTR|ATP1A3_uc010xwh.1_Silent_p.L38L|ATP1A3_uc002osh.2_Silent_p.L25L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	25	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						CCTCCTTCTTGAGGTCATCCA	0.597			NA											11	265					1.58986e-06	1.87085e-06	0.008291	1	0
PSG1	5669	broad.mit.edu	37	19	43373130	43373130	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:43373130C>T	uc002ovb.2	-	4	904	c.766G>A	c.(766-768)GAT>AAT	p.D256N	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.D256N|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.D256N|PSG1_uc010eio.1_Missense_Mutation_p.D256N|PSG1_uc002oux.1_Missense_Mutation_p.D185N|PSG1_uc002ouy.1_Intron|PSG1_uc002ouz.1_Missense_Mutation_p.D256N|PSG1_uc002ova.1_Missense_Mutation_p.D163N|PSG1_uc002ovc.2_Missense_Mutation_p.D163N|PSG1_uc002ovd.1_Missense_Mutation_p.D256N	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	256	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TTTAAGACATCCTTATTCTCC	0.493			NA											12	258					0	0	0.001368	0	0
ZFP112	7771	broad.mit.edu	37	19	44833222	44833222	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:44833222C>A	uc010ejj.2	-	5	1219	c.1106G>T	c.(1105-1107)AGT>ATT	p.S369I	ZFP112_uc002ozc.3_Missense_Mutation_p.S363I|ZFP112_uc010xwy.1_Missense_Mutation_p.S386I|ZFP112_uc010xwz.1_Missense_Mutation_p.S368I	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TAAGCTATGACTGAAGGCTTT	0.378	Melanoma(53;975 1202 7512 15993 27273)		NA											4	71					0.00024832	0.000272685	0.009096	1	0
TPRX1	284355	broad.mit.edu	37	19	48305244	48305244	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:48305244C>A	uc002php.1	-	2	1095	c.1024G>T	c.(1024-1026)GAC>TAC	p.D342Y		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	342						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		GGCAAGAAGTCGGAGGCATCG	0.363	Esophageal Squamous(123;175 2281 3051 32395)		NA											11	55					0.000673444	0.000728872	0.008291	1	0
GPR32	2854	broad.mit.edu	37	19	51274268	51274268	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:51274268G>T	uc010ycf.1	+	1	411	c.411G>T	c.(409-411)GTG>GTT	p.V137V		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	137	Helical; Name=3; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCATCTCTGTGGACCGTTGCA	0.612	Esophageal Squamous(113;152 1581 5732 15840 44398)		NA											15	141					1.33834e-09	1.71281e-09	0.007413	1	0
KIR3DL3	115653	broad.mit.edu	37	19	55246763	55246763	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:55246763C>A	uc002qgu.1	+	6	1011	c.993C>A	c.(991-993)GTC>GTA	p.V331V	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	331	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CCTCAGTGGTCATCATCCCCT	0.478			NA											55	95					3.84483e-29	6.05504e-29	0.00361	1	0
KIR3DP1	768329	broad.mit.edu	37	19	55266475	55266475	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:55266475A>T	uc010yfi.1	+	1	2	c.1A>T	c.(1-3)ATG>TTG	p.M1L	KIR2DS4_uc010yfj.1_5'UTR|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_001015070	NP_001015070			killer-cell Ig-like receptor												0				GBM - Glioblastoma multiforme(193;0.0192)		CGGCAGCACCATGTCGCTCAC	0.597			NA											22	63					0	0	0.002299	0	0
NLRP2	55655	broad.mit.edu	37	19	55494735	55494735	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:55494735T>A	uc002qij.2	+	6	1755	c.1669T>A	c.(1669-1671)TCC>ACC	p.S557T	NLRP2_uc010yfp.1_Missense_Mutation_p.S534T|NLRP2_uc010esn.2_Missense_Mutation_p.S533T|NLRP2_uc010eso.2_Missense_Mutation_p.S554T|NLRP2_uc010esp.2_Missense_Mutation_p.S535T	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	557					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGGCTACTACTCCTTTGGCCT	0.557			NA											13	66					0	0	0.001368	0	0
NLRP11	204801	broad.mit.edu	37	19	56321418	56321418	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:56321418G>A	uc010ygf.1	-	5	1269	c.558C>T	c.(556-558)CTC>CTT	p.L186L	NLRP11_uc002qlz.2_Silent_p.L87L|NLRP11_uc002qmb.2_Silent_p.L87L|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	186	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CGTGAGCAGTGAGGTGAACGA	0.502			NA											7	31					0	0	0.001984	0	0
NLRP4	147945	broad.mit.edu	37	19	56388492	56388492	+	Missense_Mutation	SNP	C	C	T	rs147716168		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:56388492C>T	uc002qmd.3	+	8	3078	c.2656C>T	c.(2656-2658)CGG>TGG	p.R886W	NLRP4_uc002qmf.2_Missense_Mutation_p.R811W|NLRP4_uc010etf.2_Missense_Mutation_p.R661W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	886	LRR 6.						ATP binding	p.R886W(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCTGTTGTGTCGGGCTCTGAC	0.498			NA											26	100					0	0	0.007291	0	0
SNTG2	54221	broad.mit.edu	37	2	1168816	1168816	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:1168816T>C	uc002qwq.2	+	8	666	c.538T>C	c.(538-540)TCC>CCC	p.S180P	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	180					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CAGTGGGGCCTCCTCTCCCCT	0.473			NA											26	198					0	0	0.002096	0	0
MYT1L	23040	broad.mit.edu	37	2	1890352	1890352	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:1890352T>G	uc002qxe.2	-	18	3497	c.2670A>C	c.(2668-2670)AAA>AAC	p.K890N	MYT1L_uc002qxd.2_Missense_Mutation_p.K888N|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	890					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TTCGAATGCTTTTGTCCGCCA	0.458			NA											10	64					0	0	0.008291	0	0
KCNS3	3790	broad.mit.edu	37	2	18112790	18112790	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:18112790G>T	uc002rcv.2	+	3	966	c.515G>T	c.(514-516)TGG>TTG	p.W172L	KCNS3_uc002rcw.2_Missense_Mutation_p.W172L	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	172	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AAGAAAATCTGGATTAGAATG	0.512			NA											14	56					1.5842e-08	1.96995e-08	0.001855	1	0
AGBL5	60509	broad.mit.edu	37	2	27278943	27278943	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:27278943T>C	uc002rie.2	+	7	1519	c.1302T>C	c.(1300-1302)CAT>CAC	p.H434H	AGBL5_uc002ric.2_Silent_p.H434H|AGBL5_uc002rid.2_Silent_p.H434H|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	434		Zinc (By similarity).			protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGACCTGCATGGACATGCTT	0.512			NA											55	258					0	0	0.00361	0	0
TCF23	150921	broad.mit.edu	37	2	27375636	27375636	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:27375636C>A	uc010ylg.1	+	3	546	c.546C>A	c.(544-546)AGC>AGA	p.S182R		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	182					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCACCCCCAGCCAAAGAACAA	0.557			NA											34	75					5.09552e-08	6.24765e-08	0.002096	1	0
SUPT7L	9913	broad.mit.edu	37	2	27880518	27880518	+	Silent	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:27880518C>G	uc002rlh.1	-	4	781	c.438G>C	c.(436-438)GTG>GTC	p.V146V	SUPT7L_uc002rli.1_Silent_p.V146V|SUPT7L_uc010ymf.1_Silent_p.V11V|SUPT7L_uc002rlj.1_Silent_p.V144V|SUPT7L_uc010ezh.1_Silent_p.V144V	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	146					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGAGTTCAGTCACAGGTTCCC	0.542			NA											5	54					0	0	0.001168	0	0
RASGRP3	25780	broad.mit.edu	37	2	33747028	33747028	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:33747028C>T	uc002rox.2	+	8	1002	c.375C>T	c.(373-375)TCC>TCT	p.S125S	RASGRP3_uc010ync.1_Silent_p.S125S|RASGRP3_uc002roy.2_Silent_p.S125S	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	125	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATAGTCCTTCCTATGACTGGA	0.443			NA											17	113					0	0	0.007413	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655749	40655749	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:40655749C>A	uc002rrx.2	-	1	1696	c.1672G>T	c.(1672-1674)GTG>TTG	p.V558L	SLC8A1_uc002rry.2_Missense_Mutation_p.V558L|SLC8A1_uc002rrz.2_Missense_Mutation_p.V558L|SLC8A1_uc002rsa.2_Missense_Mutation_p.V558L|SLC8A1_uc002rsd.3_Missense_Mutation_p.V558L|SLC8A1_uc002rsb.1_Missense_Mutation_p.V558L|SLC8A1_uc010fan.1_Missense_Mutation_p.V558L|SLC8A1_uc002rsc.1_Missense_Mutation_p.V558L	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	558	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AATACTTTCACCTCCATGATG	0.458			NA											18	148					5.3912e-06	6.2462e-06	0.006122	1	0
NRXN1	9378	broad.mit.edu	37	2	50699530	50699530	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:50699530T>A	uc010fbq.2	-	16	4747	c.3270A>T	c.(3268-3270)CAA>CAT	p.Q1090H	NRXN1_uc002rxb.3_Missense_Mutation_p.Q722H|NRXN1_uc002rxe.3_Missense_Mutation_p.Q1050H|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	229	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCAGGCAGCCTTGAAAGCCTT	0.428			NA											8	37					0	0	0.004482	0	0
ALMS1	7840	broad.mit.edu	37	2	73677809	73677809	+	Silent	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:73677809A>G	uc002sje.1	+	10	4269	c.4158A>G	c.(4156-4158)ACA>ACG	p.T1386T	ALMS1_uc002sjf.1_Silent_p.T1342T|ALMS1_uc002sjg.2_Silent_p.T772T|ALMS1_uc002sjh.1_Silent_p.T772T	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1384	18.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CACAACATACAGAGAAGCCGA	0.468			NA											48	123					0	0	0.00361	0	0
TET3	200424	broad.mit.edu	37	2	74274191	74274191	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:74274191C>G	uc002skb.3	+	1	742	c.742C>G	c.(742-744)CCC>GCC	p.P248A	TET3_uc010fez.1_Missense_Mutation_p.P248A	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	248							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGCTTCTTGCCCCCTTCCTGA	0.592			NA											38	48					0	0	0.004878	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745595	77745595	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:77745595C>A	uc002snr.2	-	3	1815	c.1400G>T	c.(1399-1401)CGG>CTG	p.R467L	LRRTM4_uc002snq.2_Missense_Mutation_p.R467L|LRRTM4_uc002sns.2_Missense_Mutation_p.R467L|LRRTM4_uc002snt.2_Missense_Mutation_p.R468L	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	467	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GGCCTTTTTCCGCCGCCTCTT	0.463			NA											16	46					6.72482e-11	8.84314e-11	0.003163	1	0
REG3A	5068	broad.mit.edu	37	2	79385590	79385590	+	Splice_Site	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:79385590C>T	uc002sod.1	-	3	451	c.196_splice	c.e3-1	p.L66_splice	REG3A_uc002soe.1_Splice_Site_p.L66_splice|REG3A_uc002sof.1_Splice_Site_p.L66_splice	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor						acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GGCAGGCCAGCTTTGAGGGCA	0.567			NA											13	78					0	0	0.004007	0	0
LONRF2	164832	broad.mit.edu	37	2	100906881	100906881	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:100906881G>C	uc002tal.3	-	10	2399	c.1759C>G	c.(1759-1761)CTT>GTT	p.L587V	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	587	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						TACTCTGAAAGCCTGAAAAGA	0.433			NA											40	83					0	0	0.006999	0	0
RGPD3	653489	broad.mit.edu	37	2	107040515	107040515	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:107040515G>C	uc010ywi.1	-	20	3965	c.3908C>G	c.(3907-3909)TCT>TGT	p.S1303C		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1303					intracellular transport		binding			ovary(1)	1						AGGAGACTTAGATAGACTCAA	0.403			NA											71	127					0	0	0.00361	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459800	107459800	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:107459800C>T	uc002tdq.2	-	2	753	c.634G>A	c.(634-636)GTC>ATC	p.V212I	ST6GAL2_uc002tdr.2_Missense_Mutation_p.V212I|ST6GAL2_uc002tds.3_Missense_Mutation_p.V212I	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	212	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.V212G(1)		pancreas(6)|ovary(4)|skin(1)	11						TTGGAAGAGACGTTCCCCTTC	0.637			NA											4	39					0	0	0.009096	0	0
SH3RF3	344558	broad.mit.edu	37	2	110065767	110065767	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:110065767C>T	uc010ywt.1	+	8	1970	c.1970C>T	c.(1969-1971)CCG>CTG	p.P657L		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	657							zinc ion binding			ovary(1)	1						CACCAGCCCCCGGTGCAGATG	0.677			NA											3	23					0	0	0.000602	0	0
SEPT10	151011	broad.mit.edu	37	2	110325451	110325451	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:110325451G>A	uc002tew.2	-	6	1082	c.703C>T	c.(703-705)CAG>TAG	p.Q235*	SEPT10_uc010ywu.1_Nonsense_Mutation_p.Q68*|SEPT10_uc002tex.2_Nonsense_Mutation_p.Q212*|SEPT10_uc002tey.2_Nonsense_Mutation_p.Q235*|SEPT10_uc010ywv.1_Nonsense_Mutation_p.Q101*|SEPT10_uc002tev.1_Nonsense_Mutation_p.Q42*|SEPT10_uc010fjo.2_RNA|SEPT10_uc002tez.1_Nonsense_Mutation_p.Q10*	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	235					cell cycle|cell division	septin complex	GTP binding				0						TGGTATATCTGGACGCCATTG	0.393			NA											20	100					0	0	0.002299	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125547612	125547612	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:125547612C>G	uc002tno.2	+	18	3247	c.2883C>G	c.(2881-2883)AGC>AGG	p.S961R	CNTNAP5_uc010flu.2_Missense_Mutation_p.S962R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	961	EGF-like 2.|Extracellular (Potential).			PGHCSS -> SIKKLK (in Ref. 4; BAB71205).	cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCCACTGCAGCAGCTACGGCA	0.547			NA											18	31					0	0	0.010504	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135893295	135893295	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:135893295A>T	uc002tuj.2	+	17	1741	c.1716A>T	c.(1714-1716)GGA>GGT	p.G572G	RAB3GAP1_uc010fnf.2_Silent_p.G572G|RAB3GAP1_uc010fng.2_Silent_p.G397G|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	572						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		GAGAGGTAGGAAAATCTTGGG	0.408			NA											17	30					0	0	0.00499	0	0
UBXN4	23190	broad.mit.edu	37	2	136536537	136536537	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:136536537G>T	uc002tur.2	+	11	1384	c.1073G>T	c.(1072-1074)GGT>GTT	p.G358V	UBXN4_uc002tus.2_Missense_Mutation_p.G124V|UBXN4_uc002tut.2_5'UTR	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	358	UBX.|Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						AACACTTACGGTAATTTTTCG	0.348			NA											17	94					5.26018e-13	7.28119e-13	0.001882	1	0
LRP1B	53353	broad.mit.edu	37	2	141242913	141242913	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:141242913C>A	uc002tvj.1	-	59	10396	c.9424G>T	c.(9424-9426)GGA>TGA	p.G3142*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3142	Extracellular (Potential).|LDL-receptor class B 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTACAAACCCAGCTTGAGGA	0.333	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			20	47					1.28384e-07	1.54885e-07	0.001882	1	0
FMNL2	114793	broad.mit.edu	37	2	153473647	153473647	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:153473647A>C	uc002tye.2	+	13	1622	c.1255A>C	c.(1255-1257)AAG>CAG	p.K419Q	FMNL2_uc010fob.2_5'Flank|FMNL2_uc002tyf.2_5'Flank	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	419	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						AGCCATGTCCAAGATTGTGGA	0.443			NA											12	74					0	0	0.001368	0	0
GALNT5	11227	broad.mit.edu	37	2	158115649	158115649	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:158115649G>T	uc002tzg.2	+	1	1310	c.1055G>T	c.(1054-1056)GGT>GTT	p.G352V	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	352	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AAAGTATTGGGTAAAAGCCAA	0.393			NA											26	111					4.47668e-21	6.72781e-21	0.003954	1	0
ITGB6	3694	broad.mit.edu	37	2	160964351	160964351	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:160964351G>A	uc002ubh.2	-	14	2123	c.2107C>T	c.(2107-2109)CCG>TCG	p.P703S	ITGB6_uc010fou.2_Missense_Mutation_p.P703S|ITGB6_uc010zcq.1_Missense_Mutation_p.P661S|ITGB6_uc010fov.1_Missense_Mutation_p.P703S	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	703	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						GGAGGCTTCGGACAATCTGCA	0.403			NA											6	53					0	0	0.001984	0	0
MYO3B	140469	broad.mit.edu	37	2	171262116	171262116	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:171262116C>A	uc002ufy.2	+	21	2636	c.2493C>A	c.(2491-2493)TGC>TGA	p.C831*	MYO3B_uc002ufv.2_Nonsense_Mutation_p.C818*|MYO3B_uc010fqb.1_Nonsense_Mutation_p.C818*|MYO3B_uc002ufz.2_Nonsense_Mutation_p.C831*|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	831	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TGGAACTGTGCTTTGGCATTC	0.413			NA											21	88					7.87624e-14	1.10477e-13	0.00278	1	0
TTN	7273	broad.mit.edu	37	2	179428882	179428882	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:179428882T>G	uc010zfg.1	-	275	74497	c.74273A>C	c.(74272-74274)AAA>ACA	p.K24758T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K18453T|TTN_uc010zfi.1_Missense_Mutation_p.K18386T|TTN_uc010zfj.1_Missense_Mutation_p.K18261T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25685							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGTAGATTTAATTTCCAT	0.378			NA											30	203					0	0	0.002836	0	0
TTN	7273	broad.mit.edu	37	2	179547582	179547582	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:179547582T>G	uc010zfg.1	-	132	29428	c.29204A>C	c.(29203-29205)GAA>GCA	p.E9735A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6396A|TTN_uc010fre.1_Missense_Mutation_p.E582A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10662							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAACAGCTTCTTCTTCTAG	0.328			NA											13	29					0	0	0.001368	0	0
CCDC141	285025	broad.mit.edu	37	2	179701812	179701812	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:179701812G>T	uc002unf.1	-	13	2466	c.2409C>A	c.(2407-2409)ACC>ACA	p.T803T	CCDC141_uc002une.1_Silent_p.T253T	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	803							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGCCCCTGCTGGTGCCTGATT	0.488			NA											19	29					2.4624e-09	3.11351e-09	0.008871	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802849	185802849	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:185802849A>T	uc002uph.2	+	4	3320	c.2726A>T	c.(2725-2727)GAT>GTT	p.D909V		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	909						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAATTGTCAGATGTTTCCAAT	0.413			NA											16	88					0	0	0.004007	0	0
MYO1B	4430	broad.mit.edu	37	2	192250719	192250719	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:192250719A>G	uc010fsg.2	+	16	1718	c.1463A>G	c.(1462-1464)CAT>CGT	p.H488R	MYO1B_uc002usq.2_Missense_Mutation_p.H488R|MYO1B_uc002usr.2_Missense_Mutation_p.H488R|MYO1B_uc002ust.1_Missense_Mutation_p.H126R	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	488	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ACCCACCAGCATTTTGAGAGC	0.522			NA											67	240					0	0	0.00361	0	0
PLCL1	5334	broad.mit.edu	37	2	198950576	198950576	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:198950576G>T	uc010fsp.2	+	2	2626	c.2335G>T	c.(2335-2337)GAT>TAT	p.D779Y	PLCL1_uc002uuv.3_Missense_Mutation_p.D700Y	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	779	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TCCTATTTTTGATGAAACTTT	0.388			NA											13	134					9.31168e-06	1.07176e-05	0.001855	1	0
ZDBF2	57683	broad.mit.edu	37	2	207171954	207171954	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:207171954A>C	uc002vbp.2	+	5	2952	c.2702A>C	c.(2701-2703)CAG>CCG	p.Q901P		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	901							nucleic acid binding|zinc ion binding			ovary(3)	3						AAAGAAGAGCAGGTACACTTA	0.368			NA											9	38					0	0	0.004482	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174447	207174447	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:207174447T>G	uc002vbp.2	+	5	5445	c.5195T>G	c.(5194-5196)CTA>CGA	p.L1732R		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1732							nucleic acid binding|zinc ion binding			ovary(3)	3						CGTTCGAAGCTAAAACATAGA	0.448			NA											13	48					0	0	0.001368	0	0
DES	1674	broad.mit.edu	37	2	220285636	220285636	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:220285636C>G	uc002vll.2	+	5	1070	c.984C>G	c.(982-984)ATC>ATG	p.I328M		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	328	Rod.|Coil 2B.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GACACCAGATCCAGTCCTACA	0.532			NA											10	30					0	0	0.006214	0	0
FARSB	10056	broad.mit.edu	37	2	223436741	223436741	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:223436741C>A	uc002vne.1	-	17	1654	c.1619G>T	c.(1618-1620)GGG>GTG	p.G540V	FARSB_uc010zlq.1_Missense_Mutation_p.G560V|FARSB_uc002vnf.1_Missense_Mutation_p.G441V	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	540					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GAAAGCAGGCCCTGAAAAAGA	0.423			NA											7	47					0.00198382	0.00211661	0.001984	1	0
KCNE4	23704	broad.mit.edu	37	2	223917638	223917638	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:223917638C>A	uc002vnl.3	+	2	244	c.90C>A	c.(88-90)AGC>AGA	p.S30R		NM_080671	NP_542402	Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related	30						integral to membrane	voltage-gated potassium channel activity			ovary(1)	1		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCGGCGGCAGCGGCAATGGCA	0.597			NA											57	69					7.47603e-22	1.13653e-21	0.00361	1	0
SLC16A14	151473	broad.mit.edu	37	2	230911413	230911413	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:230911413C>A	uc002vqd.1	-	4	792	c.429G>T	c.(427-429)CTG>CTT	p.L143L	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Silent_p.L143L|SLC16A14_uc002vqf.2_Silent_p.L143L	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	143	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CCACCGCTGGCAGGTAGGCCA	0.602			NA											6	61					0.00116845	0.00125686	0.001168	1	0
UGT1A4	54657	broad.mit.edu	37	2	234627778	234627778	+	Silent	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:234627778A>G	uc002vux.2	+	1	341	c.312A>G	c.(310-312)GAA>GAG	p.E104E	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Silent_p.E104E	NM_007120	NP_009051	P22310	UD14_HUMAN	UDP glycosyltransferase 1 family, polypeptide A4	104					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)	Imipramine(DB00458)|Lamotrigine(DB00555)|Paricalcitol(DB00910)|Trifluoperazine(DB00831)	TTGAAACAGAACATCTTCTGA	0.433	Melanoma(99;1011 1962 13201 26492)		NA											137	95					0	0	0.00361	0	0
COL6A3	1293	broad.mit.edu	37	2	238245021	238245021	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:238245021C>T	uc002vwl.2	-	40	9007	c.8722G>A	c.(8722-8724)GCC>ACC	p.A2908T	COL6A3_uc002vwo.2_Missense_Mutation_p.A2702T|COL6A3_uc010znj.1_Missense_Mutation_p.A2301T|COL6A3_uc002vwj.2_Missense_Mutation_p.A289T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2908	Nonhelical region.|Ala-rich.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTTGCAGCGGCTGGCTTCACA	0.577			NA											11	224					0	0	0.001855	0	0
OR6B3	150681	broad.mit.edu	37	2	240985297	240985297	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:240985297A>T	uc010zoe.1	-	1	193	c.193T>A	c.(193-195)TCC>ACC	p.S65T	PRR21_uc010zod.1_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		AAAGACATGGAGCTCAGAAAG	0.557			NA											20	95					0	0	0.010504	0	0
TTLL9	164395	broad.mit.edu	37	20	30525286	30525286	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:30525286C>A	uc010gdx.1	+	13	1345	c.1092C>A	c.(1090-1092)ACC>ACA	p.T364T	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Silent_p.T266T|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	364	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGGAAGACACCCTGCATGTTG	0.582			NA											9	35					1.12685e-05	1.29416e-05	0.004482	1	0
SNTA1	6640	broad.mit.edu	37	20	32026748	32026748	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:32026748C>G	uc002wzd.1	-	2	667	c.395G>C	c.(394-396)GGG>GCG	p.G132A	SNTA1_uc010zuf.1_Missense_Mutation_p.G132A	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	132	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GATGGCATCCCCCACAAAAAG	0.547			NA											16	162					0	0	0.002299	0	0
ZNF341	84905	broad.mit.edu	37	20	32354696	32354696	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:32354696C>A	uc002wzy.2	+	9	1282	c.1262C>A	c.(1261-1263)GCC>GAC	p.A421D	ZNF341_uc002wzx.2_Missense_Mutation_p.A414D|ZNF341_uc010geq.2_Missense_Mutation_p.A331D|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAGCCCCAGGCCTTGTCCACA	0.622			NA											14	298					1.49906e-05	1.71042e-05	0.00245	1	0
TOP1	7150	broad.mit.edu	37	20	39726903	39726903	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:39726903G>C	uc002xjl.2	+	11	1147	c.901G>C	c.(901-903)GAT>CAT	p.D301H		NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	301					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	AAGCAAATGTGATTTTACCCA	0.368			NA	T	NUP98	AML*								36	72					0	0	0.003755	0	0
ACOT8	10005	broad.mit.edu	37	20	44470570	44470570	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:44470570C>T	uc002xqa.1	-	6	948	c.867G>A	c.(865-867)GGG>GGA	p.G289G	SNX21_uc002xps.1_Intron|SNX21_uc002xpt.1_3'UTR|SNX21_uc002xpu.1_3'UTR|SNX21_uc002xpv.1_3'UTR|SNX21_uc002xpw.1_3'UTR|SNX21_uc002xpx.2_3'UTR|SNX21_uc010zxd.1_3'UTR|SNX21_uc002xpy.1_3'UTR|SNX21_uc002xpz.1_3'UTR	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	289					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GCCACAGCCGCCCATGGACCA	0.547			NA											7	19					0	0	0.004482	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673636	44673636	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:44673636G>T	uc010zxl.1	+	12	1571	c.1495G>T	c.(1495-1497)GTG>TTG	p.V499L	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.V476L	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	499	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAACCTCGTGGTGGGCACTCT	0.602			NA											38	180					4.32679e-17	6.21829e-17	0.006999	1	0
C20orf85	128602	broad.mit.edu	37	20	56735869	56735869	+	Silent	SNP	C	C	A	rs140824842		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:56735869C>A	uc002xyv.2	+	4	443	c.405C>A	c.(403-405)GGC>GGA	p.G135G		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	135										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			CCAAGCAGGGCGTGCACTGAA	0.602			NA											12	29					5.50884e-06	6.35449e-06	0.001368	1	0
KCNQ2	3785	broad.mit.edu	37	20	62078122	62078122	+	Nonsense_Mutation	SNP	G	G	T	rs118192194		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:62078122G>T	uc002yey.1	-	2	542	c.365C>A	c.(364-366)TCG>TAG	p.S122*	KCNQ2_uc002yez.1_Nonsense_Mutation_p.S122*|KCNQ2_uc002yfa.1_Nonsense_Mutation_p.S122*|KCNQ2_uc002yfb.1_Nonsense_Mutation_p.S122*|KCNQ2_uc011aax.1_Nonsense_Mutation_p.S122*|KCNQ2_uc002yfc.1_Nonsense_Mutation_p.S122*	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	122	Extracellular (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GGCCCCCTCCGAGCTCTTCTC	0.632			NA											43	76					3.21987e-24	4.93776e-24	0.00361	1	0
EEF1A2	1917	broad.mit.edu	37	20	62126415	62126415	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr20:62126415C>A	uc002yfd.1	-	3	465	c.364G>T	c.(364-366)GAG>TAG	p.E122*	EEF1A2_uc002yfe.1_Nonsense_Mutation_p.E122*|EEF1A2_uc010gkg.1_Nonsense_Mutation_p.E122*	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	122						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			GCCTCGAACTCGCCCACGCCC	0.682			NA											26	101					1.16021e-09	1.48846e-09	0.007291	1	0
POTED	317754	broad.mit.edu	37	21	14982875	14982875	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr21:14982875G>A	uc002yjb.1	+	1	378	c.326G>A	c.(325-327)TGC>TAC	p.C109Y		NM_174981	NP_778146	Q86YR6	POTED_HUMAN	pote protein	109						plasma membrane				ovary(3)|skin(3)	6						TTCCCCTGCTGCAGGGGGAGC	0.582			NA											6	27					0	0	0.001368	0	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127668	32127668	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr21:32127668C>A	uc011adi.1	-	1	29	c.29G>T	c.(28-30)TGT>TTT	p.C10F		NM_181619	NP_853650	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	10						intermediate filament				breast(1)	1						gccatagccacagGAGTTGCC	0.219			NA											89	119					2.16136e-38	3.49807e-38	0.00361	1	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993707	45993707	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr21:45993707C>T	uc002zfk.1	+	1	102	c.72C>T	c.(70-72)TCC>TCT	p.S24S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	24						keratin filament					0						ACTCTTGCTCCGACTCCTGGC	0.682			NA											6	90					0	0	0.001168	0	0
ITGB2	3689	broad.mit.edu	37	21	46323351	46323351	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr21:46323351A>G	uc002zgd.2	-	4	472	c.428T>C	c.(427-429)CTC>CCC	p.L143P	ITGB2_uc002zge.2_Missense_Mutation_p.L143P|ITGB2_uc002zgf.3_Missense_Mutation_p.L143P|ITGB2_uc011afl.1_Missense_Mutation_p.L65P|ITGB2_uc010gpw.2_Intron|ITGB2_uc002zgg.2_Missense_Mutation_p.L143P	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	143	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GACATTCCTGAGGTCATCAAG	0.607			NA											4	69					0	0	0.000602	0	0
PLA2G3	50487	broad.mit.edu	37	22	31534710	31534710	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr22:31534710T>A	uc003aka.2	-	2	719	c.590A>T	c.(589-591)AAC>ATC	p.N197I		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	197	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						GATGCCATAGTTGTACTGCAA	0.607			NA											62	44					0	0	0.00361	0	0
C3orf32	51066	broad.mit.edu	37	3	8672548	8672548	+	Silent	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:8672548A>C	uc003bqu.2	-	6	648	c.402T>G	c.(400-402)CCT>CCG	p.P134P	C3orf32_uc003bqz.2_Silent_p.P134P|C3orf32_uc003bqt.2_Silent_p.P83P|C3orf32_uc011atg.1_Silent_p.P156P|C3orf32_uc003bqv.2_Silent_p.P83P|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Silent_p.P134P	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	134										skin(1)	1						GAAACATCGGAGGACCTTGAA	0.532			NA											25	33					0	0	0.004656	0	0
NGLY1	55768	broad.mit.edu	37	3	25778828	25778828	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:25778828T>C	uc003cdl.2	-	6	1108	c.1000A>G	c.(1000-1002)ACA>GCA	p.T334A	NGLY1_uc010hfg.2_Missense_Mutation_p.T334A|NGLY1_uc003cdm.2_Missense_Mutation_p.T334A|NGLY1_uc011awo.1_Missense_Mutation_p.T292A|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	334					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						tctgtacctgtgTAATCCCAA	0.239			NA											5	22					0	0	0.001168	0	0
XIRP1	165904	broad.mit.edu	37	3	39227571	39227571	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:39227571C>T	uc003cjk.1	-	2	3587	c.3366G>A	c.(3364-3366)AGG>AGA	p.R1122R	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1122							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTTGCTCTTCCCTACTGACCT	0.607			NA											17	80					0	0	0.008871	0	0
XIRP1	165904	broad.mit.edu	37	3	39228427	39228427	+	Missense_Mutation	SNP	C	C	T	rs150075136		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:39228427C>T	uc003cjk.1	-	2	2731	c.2510G>A	c.(2509-2511)CGG>CAG	p.R837Q	XIRP1_uc003cji.2_Missense_Mutation_p.R837Q|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	837							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CACATCTGGCCGGCGCAGGAC	0.602			NA											5	59					0	0	0.001984	0	0
NBEAL2	23218	broad.mit.edu	37	3	47042821	47042821	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:47042821G>A	uc003cqp.2	+	29	4716	c.4537G>A	c.(4537-4539)GTG>ATG	p.V1513M	NBEAL2_uc010hjm.1_Missense_Mutation_p.V890M|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1513							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AGAGGCCCCCGTGGGGGTCCT	0.607			NA											27	39					0	0	0.002096	0	0
MAP4	4134	broad.mit.edu	37	3	47957762	47957762	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:47957762C>A	uc003csb.2	-	7	2081	c.1555G>T	c.(1555-1557)GAT>TAT	p.D519Y	MAP4_uc003csc.3_Missense_Mutation_p.D519Y|MAP4_uc011bbf.1_Missense_Mutation_p.D496Y|MAP4_uc003csf.3_Missense_Mutation_p.D536Y	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	519	17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GGAGTCACATCCTTGCCCAGA	0.517			NA											18	107					2.4624e-09	3.11351e-09	0.008871	1	0
NEK4	6787	broad.mit.edu	37	3	52800267	52800267	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:52800267A>G	uc003dfq.3	-	3	674	c.485T>C	c.(484-486)ATG>ACG	p.M162T	NEK4_uc011bej.1_Missense_Mutation_p.M73T|NEK4_uc003dfr.2_Missense_Mutation_p.M162T	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	162	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		GGTGCTAGCCATGTCACAGTG	0.448			NA											22	18					0	0	0.001882	0	0
POPDC2	64091	broad.mit.edu	37	3	119373406	119373406	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:119373406G>T	uc003ecx.1	-	2	680	c.546C>A	c.(544-546)TTC>TTA	p.F182L	POPDC2_uc010hqw.1_Missense_Mutation_p.F182L|POPDC2_uc003ecy.1_5'UTR	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	182						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		GAGAGTCCATGAACTGGTATG	0.547			NA											8	58					5.4927e-09	6.91187e-09	0.004482	1	0
PLS1	5357	broad.mit.edu	37	3	142430746	142430746	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:142430746C>G	uc010huv.2	+	16	1946	c.1787C>G	c.(1786-1788)GCC>GGC	p.A596G	PLS1_uc003euz.2_Missense_Mutation_p.A596G|PLS1_uc003eva.2_Missense_Mutation_p.A596G	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	596	CH 4.|Actin-binding 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						AAGATCGGTGCCCGGATATAT	0.378			NA											62	96					0	0	0.00361	0	0
PEX5L	51555	broad.mit.edu	37	3	179527326	179527326	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:179527326A>G	uc003fki.1	-	12	1415	c.1285T>C	c.(1285-1287)TAC>CAC	p.Y429H	PEX5L_uc011bqd.1_Missense_Mutation_p.Y386H|PEX5L_uc011bqe.1_Missense_Mutation_p.Y237H|PEX5L_uc011bqf.1_Missense_Mutation_p.Y321H|PEX5L_uc003fkj.1_Missense_Mutation_p.Y394H|PEX5L_uc010hxd.1_Missense_Mutation_p.Y427H|PEX5L_uc011bqg.1_Missense_Mutation_p.Y405H|PEX5L_uc011bqh.1_Missense_Mutation_p.Y370H	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	429					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TTCACAAGGTATTTGTACTTT	0.463			NA											10	90					0	0	0.008291	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185390392	185390392	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:185390392G>A	uc003fpo.2	-	10	1216	c.1137C>T	c.(1135-1137)TCC>TCT	p.S379S	IGF2BP2_uc010hyi.2_Silent_p.S322S|IGF2BP2_uc010hyj.2_Silent_p.S316S|IGF2BP2_uc010hyk.2_Silent_p.S243S|IGF2BP2_uc010hyl.2_Intron|IGF2BP2_uc003fpp.2_Intron|IGF2BP2_uc003fpq.2_Silent_p.S384S	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	379					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GAGATAGCACGGACAGTCCTG	0.552			NA											17	21					0	0	0.006122	0	0
FYTTD1	84248	broad.mit.edu	37	3	197505313	197505313	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr3:197505313A>C	uc003fyi.2	+	8	1055	c.836A>C	c.(835-837)GAC>GCC	p.D279A	FYTTD1_uc011bui.1_Missense_Mutation_p.D253A|FYTTD1_uc011buj.1_RNA|FYTTD1_uc011buk.1_Missense_Mutation_p.D212A	NM_032288	NP_115664	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1 isoform 1	279					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		CTGCAGTTTGACATAAACAGT	0.353			NA											8	34					0	0	0.006214	0	0
CPZ	8532	broad.mit.edu	37	4	8621184	8621185	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:8621184_8621185CC>AA	uc003glm.2	+	11	1925_1926	c.1799_1800CC>AA	c.(1798-1800)CCC>CAA	p.P600Q	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.P463Q|CPZ_uc003glo.2_Missense_Mutation_p.P589Q|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	600					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						AGGACTGGGCCCCACGACCCAC	0.673			NA											18	40					0	0	0.004672	0	0
CLNK	116449	broad.mit.edu	37	4	10542121	10542121	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:10542121G>T	uc003gmo.3	-	11	736	c.599C>A	c.(598-600)CCC>CAC	p.P200H	CLNK_uc003gmp.2_Missense_Mutation_p.P158H	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	200					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						CTCTCACCTGGGCATTCTCTG	0.522	GBM(87;402 1286 6949 13902 35851)		NA											4	43					0.000602214	0.000653123	0.000602	1	0
RAB28	9364	broad.mit.edu	37	4	13378210	13378210	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:13378210G>A	uc003gmu.2	-	6	747	c.532C>T	c.(532-534)CTT>TTT	p.L178F	RAB28_uc003gmt.2_Missense_Mutation_p.L178F|RAB28_uc011bwz.1_Missense_Mutation_p.L178F|RAB28_uc003gmv.2_RNA	NM_001017979	NP_001017979	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family isoform 1	178					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			ovary(1)|skin(1)	2						TTGATCCCAAGGATTTCAGCA	0.299			NA											13	62					0	0	0.00245	0	0
RHOH	399	broad.mit.edu	37	4	40245386	40245386	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:40245386G>T	uc003guz.2	+	3	1104	c.380G>T	c.(379-381)AGG>ATG	p.R127M		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	127					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						GGGCCCCACAGGGCCTCCTGC	0.582			NA											18	47					7.07596e-05	7.90224e-05	0.006122	1	0
LPHN3	23284	broad.mit.edu	37	4	62598771	62598771	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:62598771G>T	uc010ihh.2	+	5	867	c.694G>T	c.(694-696)GAT>TAT	p.D232Y	LPHN3_uc003hcq.3_Missense_Mutation_p.D232Y|LPHN3_uc010ihg.1_Missense_Mutation_p.D300Y|LPHN3_uc003hcs.1_Missense_Mutation_p.D61Y	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	232	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGTAAAGTTTGATTTGCGGAC	0.458			NA											8	34					1.76689e-08	2.18679e-08	0.006214	1	0
STATH	6779	broad.mit.edu	37	4	70864186	70864186	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:70864186C>T	uc003heu.1	+	2	142	c.32C>T	c.(31-33)GCT>GTT	p.A11V	STATH_uc003hev.1_Missense_Mutation_p.A11V	NM_003154	NP_003145	P02808	STAT_HUMAN	statherin isoform a	11					biomineral tissue development|negative regulation of bone mineralization|ossification|saliva secretion	extracellular region	extracellular matrix constituent, lubricant activity|hydroxyapatite binding|protein binding|structural constituent of tooth enamel			skin(1)	1						TTCATCTTGGCTCTCATGGTT	0.388			NA											7	78					0	0	0.006214	0	0
CSN3	1448	broad.mit.edu	37	4	71114826	71114826	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:71114826C>T	uc003hfe.3	+	4	257	c.199C>T	c.(199-201)CCA>TCA	p.P67S		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	67						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCAACGTAGACCAGCTATAGC	0.413			NA											9	114					0	0	0.004482	0	0
CXXC4	80319	broad.mit.edu	37	4	105412377	105412377	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:105412377T>G	uc003hxg.2	-	1	91	c.76A>C	c.(76-78)ACT>CCT	p.T26P	uc003hxh.1_Intron|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	26					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		AGGAAATTAGTATTTGCCATT	0.502			NA											17	214					0	0	0.008871	0	0
NDST4	64579	broad.mit.edu	37	4	115760534	115760534	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:115760534C>T	uc003ibu.2	-	11	2965	c.2286G>A	c.(2284-2286)CAG>CAA	p.Q762Q	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	762	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGGACATTACCTGAGAAGTAG	0.333			NA											14	72					0	0	0.004007	0	0
SPATA5	166378	broad.mit.edu	37	4	123900432	123900432	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:123900432C>A	uc003iez.3	+	10	1833	c.1760C>A	c.(1759-1761)CCT>CAT	p.P587H	SPATA5_uc003iey.2_Missense_Mutation_p.P586H	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	587					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CCTAACCTCCCTGATGTCAAG	0.423			NA											12	50					0.00010058	0.000111614	0.001368	1	0
PCDH10	57575	broad.mit.edu	37	4	134072556	134072556	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:134072556C>A	uc003iha.2	+	1	2087	c.1261C>A	c.(1261-1263)CTG>ATG	p.L421M	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.L421M	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	421	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CGAAGCCCCCCTGGACCGAGA	0.592			NA											44	173					5.99346e-17	8.59008e-17	0.00361	1	0
NPY5R	4889	broad.mit.edu	37	4	164271568	164271568	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:164271568A>G	uc003iqn.2	+	4	325	c.143A>G	c.(142-144)TAT>TGT	p.Y48C		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	48	Helical; Name=1; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTGGGCTCTATACATTTGTA	0.388	Melanoma(139;1287 1774 9781 19750 25599)		NA											14	126					0	0	0.001855	0	0
SORBS2	8470	broad.mit.edu	37	4	186544784	186544784	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:186544784G>C	uc003iyl.2	-	13	2645	c.1787C>G	c.(1786-1788)TCC>TGC	p.S596C	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.S696C|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.S500C|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.S710C|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	596						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GTCGCTGTCGGAAAACTCCAC	0.587	Esophageal Squamous(153;41 2433 9491 36028)		NA											5	45					0	0	0.001168	0	0
NKD2	85409	broad.mit.edu	37	5	1037950	1037950	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:1037950C>T	uc003jbt.1	+	10	823	c.818C>T	c.(817-819)CCC>CTC	p.P273L	NKD2_uc010itf.1_3'UTR	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	273					exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			AAGCAGGAGCCCCAGGGCAGG	0.657			NA											9	30					0	0	0.000978	0	0
SLC12A7	10723	broad.mit.edu	37	5	1089150	1089150	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:1089150C>A	uc003jbu.2	-	4	502	c.436G>T	c.(436-438)GGG>TGG	p.G146W		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	146	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCAGCCACCCCCACGATCCAC	0.657			NA											17	102					5.03518e-11	6.6713e-11	0.007413	1	0
SEMA6A	57556	broad.mit.edu	37	5	115782666	115782666	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:115782666G>A	uc010jck.2	-	19	3445	c.2736C>T	c.(2734-2736)TAC>TAT	p.Y912Y	SEMA6A_uc003krx.3_Silent_p.Y929Y|SEMA6A_uc011cwe.1_Silent_p.Y291Y|SEMA6A_uc003krv.3_Silent_p.Y339Y|SEMA6A_uc003krw.3_Silent_p.Y389Y|SEMA6A_uc010jcj.2_Silent_p.Y456Y	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	912	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		AGTCAACCCCGTAGGAAGAGG	0.577			NA											21	68					0	0	0.010504	0	0
CSNK1G3	1456	broad.mit.edu	37	5	122893250	122893250	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:122893250G>T	uc003ktm.2	+	4	1000	c.281G>T	c.(280-282)GGA>GTA	p.G94V	CSNK1G3_uc003ktl.2_Missense_Mutation_p.G94V|CSNK1G3_uc003ktn.2_Missense_Mutation_p.G94V|CSNK1G3_uc003kto.2_Missense_Mutation_p.G94V|CSNK1G3_uc011cwr.1_Missense_Mutation_p.G19V|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Missense_Mutation_p.G94V	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	94	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		AAGCAGTTAGGATCTGGAGGT	0.289	Pancreas(187;2868 2964 4353 6297)		NA											13	17					4.93089e-13	6.8615e-13	0.00245	1	0
BRD8	10902	broad.mit.edu	37	5	137501759	137501760	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:137501759_137501760CC>AA	uc003lcf.1	-	11	1090_1091	c.1035_1036GG>TT	c.(1033-1038)GTGGGG>GTTTGG	p.G346W	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.G125W|BRD8_uc003lcg.2_Missense_Mutation_p.G419W|BRD8_uc003lci.2_Missense_Mutation_p.G349W|BRD8_uc003lch.2_Missense_Mutation_p.G240W|BRD8_uc011cym.1_Missense_Mutation_p.G330W|BRD8_uc010jer.1_Missense_Mutation_p.G315W|BRD8_uc011cyn.1_Missense_Mutation_p.G305W	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	346					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGTGGATCCCCCACAGCCTCCA	0.46			NA											47	69					0	0	0.004672	0	0
FAM53C	51307	broad.mit.edu	37	5	137681066	137681066	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:137681066G>T	uc003lcv.2	+	4	1159	c.689G>T	c.(688-690)CGC>CTC	p.R230L	FAM53C_uc003lcw.2_Missense_Mutation_p.R230L|FAM53C_uc011cyq.1_Intron|FAM53C_uc011cyr.1_Intron	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	230										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCTCAGCGCCGCTTCTCCCTG	0.672			NA											50	78					1.32667e-27	2.08307e-27	0.00361	1	0
PCDHB3	56132	broad.mit.edu	37	5	140481673	140481673	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:140481673A>T	uc003lio.2	+	1	1440	c.1440A>T	c.(1438-1440)TCA>TCT	p.S480S	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	480	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGAGACTCAGGCACCAACG	0.647			NA											81	286					0	0	0.00361	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553848	140553848	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:140553848A>T	uc003lit.2	+	1	1606	c.1432A>T	c.(1432-1434)AGA>TGA	p.R478*		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	478	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCACAGACAGAGACTCGGG	0.642			NA											61	100					0	0	0.00361	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559961	140559961	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:140559961A>T	uc011dai.1	+	1	2532	c.2346A>T	c.(2344-2346)CCA>CCT	p.P782P	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	782	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTGGGCCAGAAATGGAAC	0.378			NA											46	46					0	0	0.003214	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572515	140572515	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:140572515G>T	uc003lix.2	+	1	564	c.390G>T	c.(388-390)GCG>GCT	p.A130A		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	130	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGATCACGCGCCAGTATTTC	0.423			NA											54	55					8.28887e-21	1.24215e-20	0.00361	1	0
PCDHB10	56126	broad.mit.edu	37	5	140573763	140573763	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:140573763G>T	uc003lix.2	+	1	1812	c.1638G>T	c.(1636-1638)CTG>CTT	p.L546L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	546	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAGGCGCTGGTGCGCGTGC	0.711			NA											34	33					2.47872e-24	3.82349e-24	0.002522	1	0
GRIA1	2890	broad.mit.edu	37	5	153078536	153078536	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:153078536A>G	uc003lva.3	+	10	1720	c.1355A>G	c.(1354-1356)TAC>TGC	p.Y452C	GRIA1_uc003luy.3_Missense_Mutation_p.Y452C|GRIA1_uc003luz.3_Missense_Mutation_p.Y357C|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.Y372C|GRIA1_uc011dcx.1_Missense_Mutation_p.Y383C|GRIA1_uc011dcy.1_Missense_Mutation_p.Y462C|GRIA1_uc011dcz.1_Missense_Mutation_p.Y462C|GRIA1_uc010jia.1_Missense_Mutation_p.Y432C	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	452	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CACGTGGGCTACTCCTACCGT	0.537			NA											27	33					0	0	0.003954	0	0
GRIA1	2890	broad.mit.edu	37	5	153182019	153182019	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:153182019A>G	uc003lva.3	+	15	2854	c.2489A>G	c.(2488-2490)TAC>TGC	p.Y830C	GRIA1_uc003luy.3_Missense_Mutation_p.Y830C|GRIA1_uc003luz.3_Missense_Mutation_p.Y735C|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.Y750C|GRIA1_uc011dcx.1_Missense_Mutation_p.Y761C|GRIA1_uc011dcy.1_Missense_Mutation_p.Y840C|GRIA1_uc011dcz.1_Missense_Mutation_p.Y840C	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	830	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAGTTCTGCTACAAATCCCGT	0.532			NA											70	86					0	0	0.00361	0	0
GALNT10	55568	broad.mit.edu	37	5	153789304	153789304	+	Silent	SNP	G	G	T	rs139278178		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:153789304G>T	uc003lvh.2	+	9	1500	c.1368G>T	c.(1366-1368)CCG>CCT	p.P456P	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Silent_p.P297P|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Silent_p.P127P	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	456	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TGGAGCCCCCGGCTGCAGCTT	0.274			NA											44	56					3.21987e-24	4.93776e-24	0.00361	1	0
KIF4B	285643	broad.mit.edu	37	5	154395457	154395457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:154395457C>T	uc010jih.1	+	1	2198	c.2038C>T	c.(2038-2040)CGT>TGT	p.R680C		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	680	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGAACGAGACCGTAAGAGGCA	0.433			NA											47	59					0	0	0.00361	0	0
CCDC99	54908	broad.mit.edu	37	5	169015423	169015423	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:169015423G>T	uc003mae.3	+	2	282	c.3G>T	c.(1-3)ATG>ATT	p.M1I	CCDC99_uc010jjj.2_5'UTR|CCDC99_uc011deq.1_5'UTR|CCDC99_uc010jjk.2_5'UTR	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	1					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAAGAACATGGAGGCAGATA	0.343			NA											4	39					0.00024832	0.000272685	0.009096	1	0
BTNL3	10917	broad.mit.edu	37	5	180419848	180419848	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr5:180419848C>A	uc003mmr.2	+	2	213	c.85C>A	c.(85-87)CAG>AAG	p.Q29K		NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	29	Extracellular (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			CAAGTTTGTCCAGGCCTTGGT	0.542			NA											41	53					7.63091e-17	1.09072e-16	0.007835	1	0
HUS1B	135458	broad.mit.edu	37	6	656832	656832	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:656832C>A	uc003mtg.2	-	1	133	c.113G>T	c.(112-114)AGC>ATC	p.S38I	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	38											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		GAAGCACAGGCTGTCAGGGCG	0.672			NA											7	18					0.00198382	0.00211661	0.001984	1	0
SLC22A23	63027	broad.mit.edu	37	6	3410511	3410511	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:3410511G>A	uc003mvm.3	-	3	824	c.824C>T	c.(823-825)GCA>GTA	p.A275V	SLC22A23_uc003mvn.3_5'UTR|SLC22A23_uc003mvo.3_5'UTR|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Missense_Mutation_p.A275V|SLC22A23_uc010jno.2_Missense_Mutation_p.A275V	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	275	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				CACTGACAGTGCCACAGTCAG	0.468			NA											12	25					0	0	0.001368	0	0
SLC22A23	63027	broad.mit.edu	37	6	3410527	3410527	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:3410527A>G	uc003mvm.3	-	3	808	c.808T>C	c.(808-810)TTT>CTT	p.F270L	SLC22A23_uc003mvn.3_5'UTR|SLC22A23_uc003mvo.3_5'UTR|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Missense_Mutation_p.F270L|SLC22A23_uc010jno.2_Missense_Mutation_p.F270L	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	270	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				GTCAGTCCAAAGATCAGAATG	0.463			NA											10	23					0	0	0.006214	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7986935	7986935	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:7986935G>T	uc003mxx.3	+	1	601	c.166G>T	c.(166-168)GTC>TTC	p.V56F	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CCATCGAGGTGTCGATTCCTC	0.512			NA											7	44					1.06961e-07	1.30235e-07	0.00308	1	0
HIVEP1	3096	broad.mit.edu	37	6	12125963	12125963	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:12125963G>T	uc003nac.2	+	4	6114	c.5935G>T	c.(5935-5937)GGT>TGT	p.G1979C	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1979					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AAATCCACTCGGTTTGCCCAC	0.418			NA											58	54					2.23044e-30	3.54444e-30	0.00361	1	0
HDGFL1	154150	broad.mit.edu	37	6	22570035	22570035	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:22570035G>T	uc003nds.2	+	1	358	c.231G>T	c.(229-231)GCG>GCT	p.A77A		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	77											0	Ovarian(93;0.163)					GCTTCAGCGCGGGGCTGTGGG	0.647			NA											6	15					3.59834e-05	4.06164e-05	0.001168	1	0
PEX6	5190	broad.mit.edu	37	6	42934550	42934550	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:42934550C>A	uc003otf.2	-	9	2024	c.1931G>T	c.(1930-1932)CGG>CTG	p.R644L	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	644					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GCAGGCTGCCCGGCTGCTGTG	0.577			NA											100	180					1.54877e-32	2.4913e-32	0.00361	1	0
COL21A1	81578	broad.mit.edu	37	6	55922555	55922556	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:55922555_55922556CC>AA	uc003pcs.2	-	30	3005_3006	c.2773_2774GG>TT	c.(2773-2775)GGA>TTA	p.G925L	COL21A1_uc010jzz.2_Missense_Mutation_p.G310L|COL21A1_uc011dxg.1_Missense_Mutation_p.G298L|COL21A1_uc011dxh.1_Missense_Mutation_p.G276L|COL21A1_uc003pcr.2_Missense_Mutation_p.G282L	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	925					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCCTTGGATTCCAGGTTTTCCA	0.515			NA											9	13					0	0	0.004672	0	0
PRIM2	5558	broad.mit.edu	37	6	57246828	57246828	+	Splice_Site	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:57246828G>T	uc003pdx.2	+	7	643	c.556_splice	c.e7-1	p.I186_splice	PRIM2_uc003pdw.2_Splice_Site_p.I186_splice	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TCTTAATTCAGATCCCTTTTG	0.363			NA											5	30					0.00116845	0.00125686	0.001168	1	0
PRIM2	5558	broad.mit.edu	37	6	57398165	57398165	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:57398165C>T	uc003pdx.2	+	10	955	c.868C>T	c.(868-870)CAG>TAG	p.Q290*		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	290					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTACATGCATCAGTTACATAA	0.388			NA											49	101					0	0	0.00361	0	0
TTK	7272	broad.mit.edu	37	6	80717571	80717571	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:80717571C>T	uc003pjc.2	+	3	259	c.185C>T	c.(184-186)CCA>CTA	p.P62L	TTK_uc003pjb.3_Missense_Mutation_p.P62L	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	62					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		GCAAACAACCCAGAGGACTGG	0.348			NA											22	37					0	0	0.001882	0	0
HTR1E	3354	broad.mit.edu	37	6	87725316	87725316	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:87725316G>T	uc003pli.2	+	2	967	c.264G>T	c.(262-264)TGG>TGT	p.W88C		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	88	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TGGATCGCTGGAAGCTTGGGT	0.562			NA											21	86					7.45023e-12	1.01261e-11	0.010504	1	0
ZNF292	23036	broad.mit.edu	37	6	87968813	87968813	+	Silent	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:87968813A>G	uc003plm.3	+	8	5507	c.5466A>G	c.(5464-5466)AAA>AAG	p.K1822K		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1822					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TGCCAACAAAAAGTAACATTC	0.333			NA											18	12					0	0	0.00499	0	0
KLHL32	114792	broad.mit.edu	37	6	97533105	97533105	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:97533105C>A	uc010kcm.1	+	6	987	c.515C>A	c.(514-516)TCT>TAT	p.S172Y	KLHL32_uc003poy.2_Missense_Mutation_p.S172Y|KLHL32_uc011ead.1_Missense_Mutation_p.S136Y|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.S103Y|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	172										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		AAACATCTCTCTGAACTCCTG	0.468			NA											12	81					6.40141e-05	7.16413e-05	0.000978	1	0
KLHL32	114792	broad.mit.edu	37	6	97562130	97562130	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:97562130A>G	uc010kcm.1	+	7	1571	c.1099A>G	c.(1099-1101)ACT>GCT	p.T367A	KLHL32_uc003poy.2_Missense_Mutation_p.T367A|KLHL32_uc011ead.1_Missense_Mutation_p.T331A|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.T298A|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	367	Kelch 2.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TGCTGTGAGGACTGCCTGTCG	0.572			NA											27	20					0	0	0.004656	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599608	136599608	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:136599608C>T	uc003qgx.1	-	4	664	c.411G>A	c.(409-411)AGG>AGA	p.R137R	BCLAF1_uc003qgw.1_Silent_p.R137R|BCLAF1_uc003qgy.1_Silent_p.R135R|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.R135R	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	137					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATCTTGGAGACCTAGAAGATC	0.443	Colon(142;1534 1789 5427 7063 28491)		NA											56	336					0	0	0.00361	0	0
MLLT4	4301	broad.mit.edu	37	6	168281113	168281113	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:168281113A>T	uc003qwd.2	+	6	952	c.810A>T	c.(808-810)ACA>ACT	p.T270T	MLLT4_uc003qwb.1_Silent_p.T270T|MLLT4_uc003qwc.1_Silent_p.T271T|MLLT4_uc003qwf.2_5'UTR	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	271	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGTCTACTACAGATCCTGCAG	0.393			NA	T	MLL	AL								38	144					0	0	0.004878	0	0
THBS2	7058	broad.mit.edu	37	6	169622404	169622404	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr6:169622404G>T	uc003qwt.2	-	20	3409	c.3161C>A	c.(3160-3162)CCC>CAC	p.P1054H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	1054	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGCCCGCGTGGGCTGGTCCTC	0.627	Esophageal Squamous(91;219 1934 18562 44706)		NA											19	21					6.49762e-13	8.94698e-13	0.006122	1	0
FERD3L	222894	broad.mit.edu	37	7	19184873	19184873	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:19184873G>C	uc003suo.1	-	1	172	c.113C>G	c.(112-114)TCC>TGC	p.S38C	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	38					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						GTCCCCCAAGGAGACCCCGGG	0.537			NA											24	51					0	0	0.005443	0	0
C7orf46	340277	broad.mit.edu	37	7	23731012	23731012	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:23731012C>G	uc003swo.3	+	4	523	c.434C>G	c.(433-435)TCC>TGC	p.S145C	C7orf46_uc003swq.3_Missense_Mutation_p.S145C|C7orf46_uc003swr.3_Missense_Mutation_p.S87C|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	145											0						GATTCAGGTTCCAAGTGTTCA	0.438			NA											52	113					0	0	0.00361	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378046	31378046	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:31378046C>T	uc003tch.2	-	2	1190	c.837G>A	c.(835-837)TTG>TTA	p.L279L		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	279					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						TACCATAGTCCAAGGTTTCTT	0.507			NA											7	67					0	0	0.001984	0	0
GLI3	2737	broad.mit.edu	37	7	42005160	42005160	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:42005160C>A	uc011kbh.1	-	15	3602	c.3511G>T	c.(3511-3513)GAC>TAC	p.D1171Y	GLI3_uc011kbg.1_Missense_Mutation_p.D1112Y	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1171					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GAGGACAGGTCGGCGCTTCCG	0.667			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				30	183					3.73148e-12	5.08486e-12	0.007291	1	0
MYL7	58498	broad.mit.edu	37	7	44179170	44179170	+	Splice_Site	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:44179170T>A	uc003tkg.2	-	6	390	c.378_splice	c.e6-1	p.E126_splice		NM_021223	NP_067046	Q01449	MLRA_HUMAN	myosin light chain 2a						actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity				0						TGCTTGAACCTGGGGGGTGAG	0.632			NA											18	104					0	0	0.001882	0	0
C7orf69	80099	broad.mit.edu	37	7	47857769	47857769	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:47857769T>A	uc003tnz.3	+	2	299	c.254T>A	c.(253-255)ATG>AAG	p.M85K	PKD1L1_uc003tny.1_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Intron	NM_025031	NP_079307	Q9H7B7	CG069_HUMAN	hypothetical protein LOC80099 precursor	85						extracellular region					0						AGAACACAGATGGAGACAGAG	0.488			NA											4	36					0	0	0.000602	0	0
PKD1L1	168507	broad.mit.edu	37	7	47913531	47913531	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:47913531G>T	uc003tny.1	-	24	3862	c.3862C>A	c.(3862-3864)CGC>AGC	p.R1288S		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1288	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane		p.R1288H(1)		ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CCATGGTAGCGGGGCAGCACA	0.512			NA											6	71					1.06961e-07	1.30235e-07	0.00308	1	0
PKD1L1	168507	broad.mit.edu	37	7	47955083	47955083	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:47955083C>G	uc003tny.1	-	8	1174	c.1174G>C	c.(1174-1176)GAA>CAA	p.E392Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	392	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						tctgagtcttccaggcagctg	0.045			NA											16	118					0	0	0.004007	0	0
ABCA13	154664	broad.mit.edu	37	7	48411901	48411901	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:48411901C>T	uc003toq.2	+	33	10965	c.10940C>T	c.(10939-10941)ACC>ATC	p.T3647I	ABCA13_uc010kys.1_Missense_Mutation_p.T721I|ABCA13_uc003tos.1_Missense_Mutation_p.T473I	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3647					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CACAGCAATACCTTTATTGTT	0.468			NA											9	202					0	0	0.004482	0	0
ZPBP	11055	broad.mit.edu	37	7	50070791	50070791	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:50070791C>A	uc003tou.2	-	5	673	c.603G>T	c.(601-603)CTG>CTT	p.L201L	ZPBP_uc011kci.1_Silent_p.L127L|ZPBP_uc010kyw.2_Silent_p.L200L	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	201					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GGTCAAGAAGCAGTTTGCTTA	0.333			NA											19	68					1.67942e-08	2.08343e-08	0.006122	1	0
DDC	1644	broad.mit.edu	37	7	50547497	50547497	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:50547497G>T	uc003tpf.3	-	10	1095	c.1009C>A	c.(1009-1011)CAT>AAT	p.H337N	DDC_uc010kza.2_Missense_Mutation_p.H252N|DDC_uc003tpg.3_Missense_Mutation_p.H337N	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	337					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GAATCCTGATGGCTGTGCTTC	0.507			NA											13	123					4.36969e-10	5.6752e-10	0.001855	1	0
MRPS17	51373	broad.mit.edu	37	7	56022736	56022736	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:56022736C>T	uc003trd.2	+	3	288	c.258C>T	c.(256-258)TTC>TTT	p.F86F	MRPS17_uc003trb.2_Silent_p.F181F	NM_015969	NP_057053	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17 precursor	86					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGATCGTTTTCAAAGTTGGAA	0.478			NA											22	207					0	0	0.002299	0	0
ZNF716	441234	broad.mit.edu	37	7	57529061	57529061	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:57529061T>C	uc011kdi.1	+	4	1006	c.894T>C	c.(892-894)TGT>TGC	p.C298C		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CCTACACATGTGAAGAATGTG	0.423			NA											14	27					0	0	0.001855	0	0
CACNA2D1	781	broad.mit.edu	37	7	81598227	81598227	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:81598227G>T	uc003uhr.1	-	29	2627	c.2371C>A	c.(2371-2373)CAA>AAA	p.Q791K	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	803	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AGTTTCCCTTGAATATATATT	0.289			NA											12	98					0.00400662	0.00425754	0.004007	1	0
PCLO	27445	broad.mit.edu	37	7	82451886	82451886	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:82451886G>C	uc003uhx.2	-	20	15005	c.14716C>G	c.(14716-14718)CAG>GAG	p.Q4906E	PCLO_uc003uhv.2_Missense_Mutation_p.Q4906E|PCLO_uc003uht.1_Missense_Mutation_p.Q348E|PCLO_uc003uhu.1_Missense_Mutation_p.Q327E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4768					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGGTGGGTCTGAGTGACGCTG	0.498			NA											26	236					0	0	0.004656	0	0
PCLO	27445	broad.mit.edu	37	7	82585212	82585212	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:82585212T>C	uc003uhx.2	-	5	5346	c.5057A>G	c.(5056-5058)CAG>CGG	p.Q1686R	PCLO_uc003uhv.2_Missense_Mutation_p.Q1686R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1617					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTTTTTTTCTGTGATGACTC	0.418			NA											16	64					0	0	0.003163	0	0
GRM3	2913	broad.mit.edu	37	7	86416098	86416098	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:86416098C>A	uc003uid.2	+	3	2089	c.990C>A	c.(988-990)GTC>GTA	p.V330V	GRM3_uc010lef.2_Silent_p.V328V|GRM3_uc010leg.2_Silent_p.V202V|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	330	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CCCAGCCTGTCCGCCAGTTCG	0.647	GBM(52;969 1098 3139 52280)		NA											5	39					0.000602214	0.000653123	0.000602	1	0
CCDC132	55610	broad.mit.edu	37	7	92987717	92987717	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:92987717C>A	uc003umo.2	+	28	2992	c.2864C>A	c.(2863-2865)GCT>GAT	p.A955D	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.A925D|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.A675D	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	955											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTCTAGCAGCTATAGATGAT	0.388			NA											28	121					1.04121e-07	1.27367e-07	0.005443	1	0
CYP3A5	1577	broad.mit.edu	37	7	99264642	99264642	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:99264642T>A	uc003urq.2	-	5	452	c.365A>T	c.(364-366)GAG>GTG	p.E122V	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_5'UTR|CYP3A5_uc003urr.2_Missense_Mutation_p.E9V|CYP3A5_uc011kiy.1_Missense_Mutation_p.E112V|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	122					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TTCTTCATCCTCAGCTAAAGA	0.393			NA											9	83					0	0	0.006214	0	0
CYP3A4	1576	broad.mit.edu	37	7	99366022	99366022	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:99366022T>C	uc003urv.1	-	7	729	c.625A>G	c.(625-627)AAG>GAG	p.K209E	CYP3A4_uc003urw.1_Missense_Mutation_p.K209E|CYP3A4_uc011kiz.1_Missense_Mutation_p.K168E|CYP3A4_uc011kja.1_Missense_Mutation_p.K160E|CYP3A4_uc011kjb.1_Missense_Mutation_p.K59E	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	209					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CTTAAAAGCTTCTTGGTGTTT	0.353			NA											18	113					0	0	0.008871	0	0
MUC17	140453	broad.mit.edu	37	7	100677847	100677847	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:100677847C>T	uc003uxp.1	+	3	3203	c.3150C>T	c.(3148-3150)AGC>AGT	p.S1050S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1050	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCCTGTCAGCACCACAATGG	0.502			NA											64	858					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100686347	100686347	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:100686347A>G	uc003uxp.1	+	3	11703	c.11650A>G	c.(11650-11652)ACA>GCA	p.T3884A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3884	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGTCAGCACCACACTTCCAAC	0.478			NA											11	159					0	0	0.000978	0	0
SLC26A3	1811	broad.mit.edu	37	7	107431532	107431532	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:107431532C>A	uc003ver.2	-	5	742	c.531G>T	c.(529-531)GCG>GCT	p.A177A	SLC26A3_uc003ves.2_Silent_p.A142A	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	177	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ATGCCGCCGCCGCCACCCTCA	0.483			NA											24	37					6.44725e-10	8.35284e-10	0.002299	1	0
C7orf58	79974	broad.mit.edu	37	7	120876791	120876791	+	Silent	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:120876791A>T	uc003vjq.3	+	17	2526	c.2079A>T	c.(2077-2079)CCA>CCT	p.P693P	C7orf58_uc003vjs.3_Silent_p.P693P|C7orf58_uc003vjt.3_Silent_p.P473P	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	693						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TGATTCATCCAGAGGAAACCT	0.333			NA											14	60					0	0	0.00499	0	0
FSCN3	29999	broad.mit.edu	37	7	127235724	127235724	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:127235724G>A	uc003vmd.1	+	2	727	c.508G>A	c.(508-510)GCA>ACA	p.A170T	FSCN3_uc003vmc.1_Missense_Mutation_p.A125T|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Missense_Mutation_p.A36T|FSCN3_uc010llc.1_Missense_Mutation_p.A170T	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	170						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CTGGGTGGACGCAGCAGTTCC	0.607			NA											14	80					0	0	0.001855	0	0
CPA2	1358	broad.mit.edu	37	7	129906730	129906730	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:129906730G>A	uc003vpq.2	+	1	28	c.9G>A	c.(7-9)ATG>ATA	p.M3I	CPA2_uc011kpc.1_Missense_Mutation_p.M3I	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	3					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					CCATGGCCATGAGGTTGATCC	0.443			NA											40	119					0	0	0.006999	0	0
PLXNA4	91584	broad.mit.edu	37	7	131913175	131913175	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:131913175G>A	uc003vra.3	-	6	1887	c.1658C>T	c.(1657-1659)TCG>TTG	p.S553L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	553	PSI 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTTCATCTCCGAGGCAAACCT	0.607			NA											4	47					0	0	0.009096	0	0
CHRM2	1129	broad.mit.edu	37	7	136699780	136699780	+	Silent	SNP	C	C	G	rs78847341		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:136699780C>G	uc003vtf.1	+	4	791	c.168C>G	c.(166-168)ACC>ACG	p.T56T	CHRM2_uc003vtg.1_Silent_p.T56T|CHRM2_uc003vtj.1_Silent_p.T56T|CHRM2_uc003vtk.1_Silent_p.T56T|CHRM2_uc003vtl.1_Silent_p.T56T|CHRM2_uc003vtm.1_Silent_p.T56T|CHRM2_uc003vti.1_Silent_p.T56T|CHRM2_uc003vto.1_Silent_p.T56T|CHRM2_uc003vtn.1_Silent_p.T56T|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	56	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACCTCCAGACCGTCAACAATT	0.458			NA											20	135					0	0	0.007413	0	0
MGAM	8972	broad.mit.edu	37	7	141802436	141802436	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:141802436A>T	uc003vwy.2	+	46	5336	c.5282A>T	c.(5281-5283)TAT>TTT	p.Y1761F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1761	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCAGATACCTATGGGAAAGGA	0.423			NA											4	30					0	0	0.009096	0	0
PRSS1	5644	broad.mit.edu	37	7	142459841	142459841	+	Nonsense_Mutation	SNP	C	C	A	rs141847266	by1000genomes	TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142459841C>A	uc003wak.2	+	3	434	c.417C>A	c.(415-417)TGC>TGA	p.C139*	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Nonsense_Mutation_p.C79*	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	139	Peptidase S1.		C -> F (in PCTT).		digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GCACGAAGTGCCTCATCTCTG	0.562			NA							Hereditary_Pancreatitis				22	72					1.10923e-09	1.42654e-09	0.00278	1	0
EPHB6	2051	broad.mit.edu	37	7	142562249	142562250	+	Missense_Mutation	DNP	AC	AC	TA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142562249_142562250AC>TA	uc011kst.1	+	7	1478_1479	c.691_692AC>TA	c.(691-693)ACC>TAC	p.T231Y	EPHB6_uc011ksu.1_Missense_Mutation_p.T231Y|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_Intron|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	231	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CTTCTCCTACACCTGCCCTGCC	0.668			NA											29	116					0	0	0.004672	0	0
TRPV6	55503	broad.mit.edu	37	7	142575012	142575012	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142575012C>T	uc003wbx.1	-	4	586	c.370G>A	c.(370-372)GCT>ACT	p.A124T	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	124	ANK 3.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					TTCACAACAGCGATGTGCAGT	0.627			NA											32	58					0	0	0.002445	0	0
TRPV5	56302	broad.mit.edu	37	7	142612512	142612512	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142612512T>C	uc003wby.1	-	10	1515	c.1251A>G	c.(1249-1251)GGA>GGG	p.G417G		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	417	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GAATCGTCTTTCCAAAATAGC	0.507			NA											29	114					0	0	0.002445	0	0
TRPV5	56302	broad.mit.edu	37	7	142622786	142622786	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142622786C>T	uc003wby.1	-	8	1224	c.960G>A	c.(958-960)AAG>AAA	p.K320K	TRPV5_uc003wbz.2_Silent_p.K320K	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	320	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					ACTTGTTCCACTTGAAGCTCA	0.532			NA											4	37					0	0	0.000602	0	0
KEL	3792	broad.mit.edu	37	7	142649608	142649608	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142649608C>A	uc003wcb.2	-	10	1401	c.1191G>T	c.(1189-1191)GAG>GAT	p.E397D		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	397	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TGGGTGGTTGCTCTGTCAGTT	0.532			NA											9	67					3.86212e-05	4.34076e-05	0.008291	1	0
CASP2	835	broad.mit.edu	37	7	142997328	142997328	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:142997328C>T	uc003wco.2	+	8	1055	c.908C>T	c.(907-909)GCC>GTC	p.A303V	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Missense_Mutation_p.A187V|CASP2_uc003wcq.2_RNA|CASP2_uc011ktb.1_Missense_Mutation_p.A53V	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	303					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					TTTGACAACGCCAACTGCCCA	0.527			NA											6	87					0	0	0.001984	0	0
OR2A25	392138	broad.mit.edu	37	7	143771910	143771910	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:143771910G>T	uc011ktx.1	+	1	598	c.598G>T	c.(598-600)GCA>TCA	p.A200S		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					AATGGTTTTGGCAGGGGCAGT	0.443			NA											22	168					2.70639e-06	3.15646e-06	0.002299	1	0
C7orf29	113763	broad.mit.edu	37	7	150027807	150027807	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:150027807A>G	uc003wgy.2	+	1	870	c.314A>G	c.(313-315)TAC>TGC	p.Y105C	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	105										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GTCCTCGTGTACAAGGTGAAG	0.577			NA											12	106					0	0	0.000978	0	0
CSMD1	64478	broad.mit.edu	37	8	2830736	2830736	+	Silent	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:2830736G>C	uc011kwk.1	-	57	9219	c.8829C>G	c.(8827-8829)CTC>CTG	p.L2943L	CSMD1_uc011kwj.1_Silent_p.L2272L|CSMD1_uc010lrg.2_Silent_p.L953L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2943	Extracellular (Potential).|Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGAGAAGCGGAGAAGACTCT	0.537			NA											24	84					0	0	0.002299	0	0
RP1L1	94137	broad.mit.edu	37	8	10470122	10470122	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:10470122C>G	uc003wtc.2	-	4	1715	c.1486G>C	c.(1486-1488)GGA>CGA	p.G496R		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	496					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGCTCCCTCCAGCTTTCCGC	0.706			NA											13	20					0	0	0.001855	0	0
NAT1	9	broad.mit.edu	37	8	18080399	18080399	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:18080399C>A	uc010ltd.2	+	5	1210	c.843C>A	c.(841-843)CCC>CCA	p.P281P	NAT1_uc003wyt.2_Silent_p.P343P|NAT1_uc003wyu.2_Silent_p.P281P|NAT1_uc003wyv.2_Silent_p.P281P|NAT1_uc010ltc.2_Silent_p.P281P|NAT1_uc003wys.2_Silent_p.P343P|NAT1_uc003wyr.2_Silent_p.P281P|NAT1_uc003wyq.2_Silent_p.P281P|NAT1_uc011kyl.1_Silent_p.P281P	NM_001160179	NP_001153651	P18440	ARY1_HUMAN	N-acetyltransferase 1 isoform a	281					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity				0				Colorectal(111;0.0519)|COAD - Colon adenocarcinoma(73;0.208)		AGCTTGTGCCCAAACATGGTG	0.244			NA											6	20					8.12818e-05	9.03895e-05	0.001984	1	0
PXDNL	137902	broad.mit.edu	37	8	52366085	52366085	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:52366085C>A	uc003xqu.3	-	10	1344	c.1243G>T	c.(1243-1245)GTA>TTA	p.V415L		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	415					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ATACCTTGTACAATTATGTTT	0.408			NA											17	64					4.96729e-08	6.10466e-08	0.008871	1	0
KCNB2	9312	broad.mit.edu	37	8	73850139	73850139	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:73850139G>A	uc003xzb.2	+	3	3137	c.2549G>A	c.(2548-2550)AGT>AAT	p.S850N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	850	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GAAGAGGGCAGTGTGGGCTCT	0.532			NA											16	61					0	0	0.003163	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763201	77763201	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:77763201G>A	uc003yav.2	+	10	4296	c.3909G>A	c.(3907-3909)CAG>CAA	p.Q1303Q	ZFHX4_uc003yau.1_Silent_p.Q1348Q|ZFHX4_uc003yaw.1_Silent_p.Q1303Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1303						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGAGGAGCAGAAACCGACTA	0.408			NA								HNSCC(33;0.089)			5	14					0	0	0.000602	0	0
VPS13B	157680	broad.mit.edu	37	8	100026089	100026089	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:100026089G>A	uc003yiv.2	+	2	184	c.73G>A	c.(73-75)GAT>AAT	p.D25N	VPS13B_uc003yiw.2_Missense_Mutation_p.D25N|VPS13B_uc003yit.2_Missense_Mutation_p.D25N|VPS13B_uc003yiu.1_Missense_Mutation_p.D25N|VPS13B_uc003yis.2_Missense_Mutation_p.D25N|VPS13B_uc011lgy.1_5'UTR	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	25					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAAGCCGTCGGATCTACAGCT	0.428	Colon(161;2205 2542 7338 31318)		NA											37	229					0	0	0.004878	0	0
VPS13B	157680	broad.mit.edu	37	8	100523444	100523444	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:100523444G>C	uc003yiv.2	+	29	4523	c.4412G>C	c.(4411-4413)CGA>CCA	p.R1471P	VPS13B_uc003yiw.2_Missense_Mutation_p.R1446P|VPS13B_uc003yix.1_Missense_Mutation_p.R941P	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1471					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGAAATGAGCGAAGAAGTTTT	0.373	Colon(161;2205 2542 7338 31318)		NA											44	79					0	0	0.00874	0	0
CSMD3	114788	broad.mit.edu	37	8	114326875	114326875	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:114326875G>C	uc003ynu.2	-	2	485	c.326C>G	c.(325-327)TCA>TGA	p.S109*	CSMD3_uc003ynt.2_Nonsense_Mutation_p.S69*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S109*|CSMD3_uc010mcx.1_Nonsense_Mutation_p.S109*|CSMD3_uc003ynx.3_Nonsense_Mutation_p.S109*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	109	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAGAGCAAATGACTGAAAAAC	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	78					0	0	0.002299	0	0
COL22A1	169044	broad.mit.edu	37	8	139737644	139737644	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:139737644G>T	uc003yvd.2	-	24	2626	c.2179C>A	c.(2179-2181)CCG>ACG	p.P727T	COL22A1_uc011ljo.1_Missense_Mutation_p.P27T	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	727	Collagen-like 5.|Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAACCTCCCGGTCCAGGGGGG	0.582			NA								HNSCC(7;0.00092)			40	55					4.14194e-30	6.56222e-30	0.002852	1	0
EEF1D	1936	broad.mit.edu	37	8	144662698	144662698	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:144662698G>C	uc011lki.1	-	6	859	c.590C>G	c.(589-591)TCC>TGC	p.S197C	NAPRT1_uc003yym.3_5'Flank|NAPRT1_uc003yyn.3_5'Flank|NAPRT1_uc011lkh.1_5'Flank|NAPRT1_uc003yyo.3_5'Flank|EEF1D_uc003yyp.1_Missense_Mutation_p.S539C|EEF1D_uc003yyq.1_Missense_Mutation_p.S613C|EEF1D_uc011lkj.1_Missense_Mutation_p.S562C|EEF1D_uc003yyr.2_Missense_Mutation_p.S563C|EEF1D_uc003yyt.2_Missense_Mutation_p.S563C|EEF1D_uc011lkk.1_Missense_Mutation_p.S197C|EEF1D_uc003yys.2_Missense_Mutation_p.S197C|EEF1D_uc003yyv.2_Missense_Mutation_p.S173C|EEF1D_uc003yyu.2_Missense_Mutation_p.S197C|EEF1D_uc011lkl.1_Missense_Mutation_p.S178C	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	197					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CAGCAGGATGGAGGACTTGGC	0.667			NA											38	54					0	0	0.004878	0	0
SLC1A1	6505	broad.mit.edu	37	9	4573997	4573997	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:4573997G>T	uc003zij.1	+	8	1094	c.858G>T	c.(856-858)ATG>ATT	p.M286I	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	286					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	GCCTTTACATGGCCACAGTCC	0.453			NA											53	99					4.0181e-32	6.44366e-32	0.00361	1	0
JAK2	3717	broad.mit.edu	37	9	5054660	5054660	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:5054660C>A	uc010mhm.2	+	6	825	c.712C>A	c.(712-714)CAG>AAG	p.Q238K	JAK2_uc003ziw.2_Missense_Mutation_p.Q238K	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	238	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		CAGATTTATTCAGCAATTCAG	0.368			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				18	124					3.51602e-12	4.8037e-12	0.008871	1	0
JAK2	3717	broad.mit.edu	37	9	5054741	5054741	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:5054741T>G	uc010mhm.2	+	6	906	c.793T>G	c.(793-795)TTC>GTC	p.F265V	JAK2_uc003ziw.2_Missense_Mutation_p.F265V	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	265	FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GCAGTCTGCCTTCTACACAGA	0.393			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				11	67					0	0	0.008291	0	0
JAK2	3717	broad.mit.edu	37	9	5054743	5054743	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:5054743C>G	uc010mhm.2	+	6	908	c.795C>G	c.(793-795)TTC>TTG	p.F265L	JAK2_uc003ziw.2_Missense_Mutation_p.F265L	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	265	FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		AGTCTGCCTTCTACACAGAGA	0.393			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				11	64					0	0	0.008291	0	0
TRPM3	80036	broad.mit.edu	37	9	73461370	73461370	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:73461370C>A	uc004aid.2	-	4	844	c.600G>T	c.(598-600)AAG>AAT	p.K200N	TRPM3_uc004ahu.2_Missense_Mutation_p.K30N|TRPM3_uc004ahv.2_Missense_Mutation_p.K30N|TRPM3_uc004ahw.2_Missense_Mutation_p.K47N|TRPM3_uc004ahx.2_Missense_Mutation_p.K47N|TRPM3_uc004ahy.2_Missense_Mutation_p.K47N|TRPM3_uc004ahz.2_Missense_Mutation_p.K47N|TRPM3_uc004aia.2_Missense_Mutation_p.K47N|TRPM3_uc004aib.2_Missense_Mutation_p.K47N|TRPM3_uc004aic.2_Missense_Mutation_p.K200N|TRPM3_uc010mor.2_Missense_Mutation_p.K200N|TRPM3_uc004aie.2_Missense_Mutation_p.K47N|TRPM3_uc004aif.2_Missense_Mutation_p.K47N|TRPM3_uc004aig.2_Missense_Mutation_p.K47N|TRPM3_uc004aii.2_Missense_Mutation_p.K202N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	200	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CAAAGACTTGCTTGAGTTTTG	0.483			NA											51	183					7.84493e-40	1.28549e-39	0.00361	1	0
TMEM2	23670	broad.mit.edu	37	9	74312911	74312911	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:74312911C>G	uc011lsa.1	-	20	4127	c.3587G>C	c.(3586-3588)GGC>GCC	p.G1196A	TMEM2_uc011lrz.1_Missense_Mutation_p.G189A|TMEM2_uc010mos.2_Missense_Mutation_p.G1133A|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.G30A	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1196						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CTGCCGAGTGCCACAGCCTTG	0.483			NA											14	48					0	0	0.003163	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318455	79318455	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:79318455A>T	uc010mpk.2	-	9	8198	c.8074T>A	c.(8074-8076)TCT>ACT	p.S2692T	PRUNE2_uc004akj.3_Missense_Mutation_p.S145T|PRUNE2_uc010mpl.1_Missense_Mutation_p.S145T	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2692					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ACTGGACCAGAGGCTTCCTCT	0.542			NA											8	91					0	0	0.006214	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318981	79318981	+	Silent	SNP	T	T	C			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:79318981T>C	uc010mpk.2	-	9	7672	c.7548A>G	c.(7546-7548)GAA>GAG	p.E2516E	PRUNE2_uc004akj.3_5'UTR|PRUNE2_uc010mpl.1_5'UTR	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2516					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GAATTGTTTTTTCTTCTTCCA	0.368			NA											43	134					0	0	0.00874	0	0
CEP78	84131	broad.mit.edu	37	9	80858483	80858483	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:80858483A>T	uc004akx.2	+	5	985	c.709A>T	c.(709-711)AAC>TAC	p.N237Y	CEP78_uc004aky.3_Missense_Mutation_p.N237Y|CEP78_uc010mpp.2_Missense_Mutation_p.N237Y|CEP78_uc011lsp.1_Missense_Mutation_p.N150Y	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	237				CN -> GY (in Ref. 3; BAB14190).	G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						ACTGAATTGCAACACACTTAT	0.443			NA											16	39					0	0	0.004007	0	0
TMEM38B	55151	broad.mit.edu	37	9	108510377	108510377	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:108510377G>T	uc004bcu.1	+	5	683	c.566G>T	c.(565-567)GGG>GTG	p.G189V	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	189	Lumenal (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						ACCCTGCTGGGGTCAGTTATC	0.383			NA											27	62					1.77063e-15	2.51038e-15	0.005443	1	0
ACTL7A	10881	broad.mit.edu	37	9	111625106	111625106	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:111625106G>T	uc004bdj.1	+	1	504	c.504G>T	c.(502-504)TTG>TTT	p.L168F		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	168						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						ATGCGGTCTTGGTTTCAGACC	0.522	Esophageal Squamous(177;1480 3591 17554)		NA											26	47					4.4004e-07	5.27246e-07	0.00333	1	0
C9orf5	23731	broad.mit.edu	37	9	111798569	111798569	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:111798569T>A	uc004bdt.3	-	16	2348	c.2316A>T	c.(2314-2316)TTA>TTT	p.L772F	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.L764F	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	772						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		CCTTGCATCCTAACCCTTGTG	0.448			NA											6	65					0	0	0.001168	0	0
KIAA1958	158405	broad.mit.edu	37	9	115421717	115421717	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:115421717A>T	uc004bgf.1	+	4	1694	c.1519A>T	c.(1519-1521)ACC>TCC	p.T507S	KIAA1958_uc011lwx.1_Missense_Mutation_p.T535S	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	507										skin(1)	1						CAGCTCCTCCACCAAGAAACT	0.582			NA											5	30					0	0	0.000602	0	0
ZNF618	114991	broad.mit.edu	37	9	116811305	116811305	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:116811305C>A	uc004bid.2	+	15	1822	c.1723C>A	c.(1723-1725)CAC>AAC	p.H575N	ZNF618_uc004bic.2_Missense_Mutation_p.H482N|ZNF618_uc011lxi.1_Missense_Mutation_p.H542N|ZNF618_uc011lxj.1_Missense_Mutation_p.H543N|ZNF618_uc010mvb.2_Missense_Mutation_p.H165N	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGAGGGCAACCACATCAAGAG	0.597			NA											19	40					2.94398e-08	3.63506e-08	0.007413	1	0
TLR4	7099	broad.mit.edu	37	9	120474958	120474958	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:120474958C>A	uc004bjz.2	+	3	843	c.552C>A	c.(550-552)AGC>AGA	p.S184R	TLR4_uc004bka.2_Missense_Mutation_p.S144R|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	184	Extracellular (Potential).|LRR 6.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACCTTTCCAGCAACAAGATTC	0.383			NA											31	85					1.7881e-09	2.28287e-09	0.008361	1	0
MORN5	254956	broad.mit.edu	37	9	124936822	124936822	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:124936822G>T	uc004blw.2	+	4	417	c.355G>T	c.(355-357)GGC>TGC	p.G119C	MORN5_uc011lyn.1_Missense_Mutation_p.G119C|MORN5_uc011lyo.1_Missense_Mutation_p.R81S	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	119											0						AATCCCCAAGGGCTATTACGA	0.463			NA											9	91					3.09899e-07	3.72161e-07	0.004482	1	0
OR1J4	26219	broad.mit.edu	37	9	125281709	125281709	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:125281709G>T	uc011lyw.1	+	1	290	c.290G>T	c.(289-291)TGT>TTT	p.C97F		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATGCAGGGTGTGTAACTCAG	0.423			NA											58	136					2.27459e-33	3.67005e-33	0.00361	1	0
PDCL	5082	broad.mit.edu	37	9	125582562	125582562	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:125582562C>T	uc004bmz.1	-	4	804	c.708G>A	c.(706-708)CTG>CTA	p.L236L	PDCL_uc004bna.2_3'UTR	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	236					signal transduction|visual perception						0						TATAGATCAGCAGGGCAGGAA	0.517			NA											12	67					0	0	0.000978	0	0
CRB2	286204	broad.mit.edu	37	9	126133381	126133381	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:126133381G>T	uc004bnx.1	+	8	2052	c.1960G>T	c.(1960-1962)GCC>TCC	p.A654S	CRB2_uc004bnw.1_Missense_Mutation_p.A654S	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	654	Extracellular (Potential).|Laminin G-like 2.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CTTGGGAGGCGCCCCAAGCTC	0.617			NA											68	130					1.77791e-30	2.83389e-30	0.00361	1	0
DNM1	1759	broad.mit.edu	37	9	131008720	131008720	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:131008720G>T	uc011mau.1	+	16	1806	c.1719G>T	c.(1717-1719)CGG>CGT	p.R573R	DNM1_uc011mat.1_Silent_p.R573R|DNM1_uc004bub.1_5'UTR|DNM1_uc004buc.1_Silent_p.R40R|DNM1_uc004bud.3_RNA|uc004bue.1_5'Flank|MIR199B_hsa-mir-199b|MI0000282_5'Flank|hsa-mir-3154|MI0014182_5'Flank	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	573	PH.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						TCAAGCTGCGGGACGTGGAGA	0.562	GBM(113;146 1575 2722 28670 29921)		NA											15	44					6.72482e-11	8.84314e-11	0.003163	1	0
GOLGA2	2801	broad.mit.edu	37	9	131023512	131023512	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:131023512T>A	uc011maw.1	-	16	1291	c.1278A>T	c.(1276-1278)GAA>GAT	p.E426D	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_5'Flank|GOLGA2_uc004bul.1_Missense_Mutation_p.E327D|uc004bun.2_5'Flank	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	426	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						TCATGCTACATTCCTTCTCCT	0.597			NA											14	116					0	0	0.00499	0	0
TOR1B	27348	broad.mit.edu	37	9	132571214	132571214	+	Silent	SNP	G	G	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:132571214G>T	uc004byk.1	+	4	732	c.672G>T	c.(670-672)ACG>ACT	p.T224T		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	224					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				TAACTAAGACGGCTCTTGACT	0.408			NA											48	78					2.43468e-25	3.76659e-25	0.00361	1	0
ABL1	25	broad.mit.edu	37	9	133759423	133759424	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:133759423_133759424CG>AA	uc004bzw.2	+	11	1749_1750	c.1746_1747CG>AA	c.(1744-1749)GGCGGC>GGAAGC	p.G583S	ABL1_uc004bzv.2_Missense_Mutation_p.G602S	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	583					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCCCGGAGGGCGGCCTGAATGA	0.535			NA	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								39	163					0	0	0.004672	0	0
NTNG2	84628	broad.mit.edu	37	9	135116431	135116431	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:135116431C>A	uc004cbh.2	+	7	2133	c.1357C>A	c.(1357-1359)CCC>ACC	p.P453T		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	453	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GGGCTGCTACCGTGAGTGCGC	0.527			NA											6	12					4.096e-09	5.16666e-09	0.001168	1	0
CELP	1057	broad.mit.edu	37	9	135961698	135961698	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:135961698A>G	uc011mcu.1	+	4	533	c.440A>G	c.(439-441)TAC>TGC	p.Y147C		NR_001275				Homo sapiens cDNA FLJ25862 fis, clone CBR01781.												0						ATGCCCGTCTACCCCAAATGG	0.617			NA											8	28					0	0	0.004482	0	0
VAV2	7410	broad.mit.edu	37	9	136661611	136661611	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:136661611C>G	uc004ces.2	-	11	1018	c.972G>C	c.(970-972)AAG>AAC	p.K324N	VAV2_uc004cer.2_Missense_Mutation_p.K319N	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	324	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGTCTTGCAGCTTAAATTTTC	0.612			NA											9	31					0	0	0.000978	0	0
COL5A1	1289	broad.mit.edu	37	9	137716610	137716610	+	Silent	SNP	G	G	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:137716610G>A	uc004cfe.2	+	62	5245	c.4863G>A	c.(4861-4863)GAG>GAA	p.E1621E	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1621	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGAAGCTGGAGATTGAGCAGA	0.627			NA											5	65					0	0	0.000602	0	0
OLFM1	10439	broad.mit.edu	37	9	138011928	138011928	+	Silent	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr9:138011928C>T	uc010nar.2	+	6	1678	c.1362C>T	c.(1360-1362)TAC>TAT	p.Y454Y	OLFM1_uc004cfl.3_Silent_p.Y436Y|OLFM1_uc004cfn.3_Silent_p.Y205Y	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	454	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TGCTGGACTACAACCCCAAGG	0.537			NA											25	106					0	0	0.00278	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821840	5821840	+	Silent	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:5821840C>A	uc010ndh.2	-	5	1380	c.879G>T	c.(877-879)CCG>CCT	p.P293P	NLGN4X_uc004crp.2_Silent_p.P313P|NLGN4X_uc004crq.2_Silent_p.P293P|NLGN4X_uc010ndi.2_Silent_p.P330P|NLGN4X_uc004crr.2_Silent_p.P293P|NLGN4X_uc010ndj.2_Silent_p.P293P	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	293	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TGTACTTGGCCGGCTGGTAGT	0.542			NA											19	28					5.3912e-06	6.2462e-06	0.006122	1	0
GLRA2	2742	broad.mit.edu	37	X	14625333	14625333	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:14625333C>A	uc010nep.2	+	7	990	c.658C>A	c.(658-660)CAG>AAG	p.Q220K	GLRA2_uc010neq.2_Missense_Mutation_p.Q220K|GLRA2_uc004cwe.3_Missense_Mutation_p.Q220K|GLRA2_uc011mio.1_Missense_Mutation_p.Q131K|GLRA2_uc011mip.1_Missense_Mutation_p.Q198K	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	220	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GACCCTGCCCCAGTTTATTTT	0.388			NA											31	31					7.11191e-15	1.00291e-14	0.002836	1	0
SATL1	340562	broad.mit.edu	37	X	84362581	84362581	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:84362581C>A	uc011mqx.1	-	1	1394	c.1394G>T	c.(1393-1395)AGT>ATT	p.S465I	SATL1_uc004een.2_Missense_Mutation_p.S465I	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	278	Gln-rich.						N-acetyltransferase activity			breast(2)	2						TTGGTTCTTACTTGATTGGCT	0.582			NA											22	52					2.89027e-11	3.83909e-11	0.002299	1	0
GABRA3	2556	broad.mit.edu	37	X	151366116	151366116	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:151366116C>A	uc010ntk.1	-	8	1160	c.920G>T	c.(919-921)CGT>CTT	p.R307L		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	307	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAGACTGTACGGGCAGGAAC	0.463	NSCLC(142;2578 2613 10251 16743)		NA											37	10					3.3946e-10	4.45277e-10	0.005524	1	0
HCFC1	3054	broad.mit.edu	37	X	153225260	153225260	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:153225260C>G	uc004fjp.2	-	8	1965	c.1437G>C	c.(1435-1437)AGG>AGC	p.R479S		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	479					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCTTGAGTCCTGGCTGCGG	0.677			NA											27	15					0	0	0.00632	0	0
FLNA	2316	broad.mit.edu	37	X	153577387	153577387	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chrX:153577387C>T	uc004fkk.2	-	48	8023	c.7774G>A	c.(7774-7776)GTG>ATG	p.V2592M	FLNA_uc004fki.2_Missense_Mutation_p.V632M|FLNA_uc011mzn.1_Missense_Mutation_p.V725M|FLNA_uc010nuu.1_Missense_Mutation_p.V2584M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2592	Self-association site, tail.|Filamin 24.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGAACCCCCACCAGCAGCATG	0.642			NA											6	8					0	0	0.001168	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819100	50819100	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr10:50819100delG	uc001jhw.2	+	1	754	c.314delG	c.(313-315)TGGfs	p.W105fs	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	105	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						ACAGCTGCGTGGCCAGCGGGC	0.677			NA											24	82	---	---	---	---	NA	NA	NA	NA	NA
CSDA	8531	broad.mit.edu	37	12	10854578	10854578	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:10854578delG	uc001qyt.2	-	8	1277	c.1034delC	c.(1033-1035)CCTfs	p.P345fs	CSDA_uc001qyu.2_Frame_Shift_Del_p.P276fs	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	345					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					ATCTTGTGAAGGAGCGTTAGG	0.507			NA											11	382	---	---	---	---	NA	NA	NA	NA	NA
DDX11	1663	broad.mit.edu	37	12	31242861	31242862	+	In_Frame_Ins	INS	-	-	GGC			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr12:31242861_31242862insGGC	uc001rjt.1	+	9	1173_1174	c.922_923insGGC	c.(922-924)AGG>AGGCGG	p.308_308R>RR	DDX11_uc010sjw.1_3'UTR|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_In_Frame_Ins_p.308_308R>RR|DDX11_uc001rjs.1_In_Frame_Ins_p.308_308R>RR|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_In_Frame_Ins_p.308_308R>RR|DDX11_uc001rjw.1_In_Frame_Ins_p.282_282R>RR|DDX11_uc001rjx.1_5'UTR|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	308	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AAAGAGGAGGAGGCAGGAGAAG	0.589			NA								Multiple Myeloma(12;0.14)			11	18	---	---	---	---	NA	NA	NA	NA	NA
KLHL1	57626	broad.mit.edu	37	13	70314545	70314545	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr13:70314545delC	uc001vip.2	-	8	2577	c.1783delG	c.(1783-1785)GTAfs	p.V595fs	KLHL1_uc010thm.1_Frame_Shift_Del_p.V534fs	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	595	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AATGCTGCTACACCAACTGTG	0.333			NA											8	31	---	---	---	---	NA	NA	NA	NA	NA
ARID4A	5926	broad.mit.edu	37	14	58830971	58830972	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr14:58830971_58830972insA	uc001xdp.2	+	20	2418_2419	c.2164_2165insA	c.(2164-2166)GAAfs	p.E722fs	ARID4A_uc001xdo.2_Frame_Shift_Ins_p.E722fs|ARID4A_uc001xdq.2_Frame_Shift_Ins_p.E722fs|ARID4A_uc010apg.1_Frame_Shift_Ins_p.E400fs	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	722					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						AGATGAACTAGAAAAAAATGAA	0.277			NA											13	66	---	---	---	---	NA	NA	NA	NA	NA
CYTSB	92521	broad.mit.edu	37	17	20209395	20209395	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr17:20209395delG	uc002gwq.2	+	14	3262	c.3117delG	c.(3115-3117)CTGfs	p.L1039fs	CYTSB_uc002gws.2_Frame_Shift_Del_p.L1039fs|CYTSB_uc002gwv.2_Frame_Shift_Del_p.L958fs|CYTSB_uc010vzf.1_Frame_Shift_Del_p.L379fs|CYTSB_uc002gww.2_Frame_Shift_Del_p.L776fs	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	1039	CH.					nucleus					0						AACCCAGCCTGGTACGTATCC	0.358			NA											42	49	---	---	---	---	NA	NA	NA	NA	NA
ZNF14	7561	broad.mit.edu	37	19	19822589	19822592	+	Frame_Shift_Del	DEL	TCTC	TCTC	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	TCTC	TCTC	-	-	TCTC	TCTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:19822589_19822592delTCTC	uc002nnk.1	-	4	1652_1655	c.1498_1501delGAGA	c.(1498-1503)GAGAAAfs	p.E500fs		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	500_501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				TCATAGGGTTTCTCTCCAGTGTGT	0.387			NA											16	172	---	---	---	---	NA	NA	NA	NA	NA
ISOC2	79763	broad.mit.edu	37	19	55967772	55967772	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr19:55967772delG	uc002qlb.2	-	2	256	c.82delC	c.(82-84)CGCfs	p.R28fs	ISOC2_uc002qla.2_Frame_Shift_Del_p.R28fs|ISOC2_uc002qlc.2_Frame_Shift_Del_p.R28fs	NM_001136201	NP_001129673	Q96AB3	ISOC2_HUMAN	isochorismatase domain containing 2 isoform 1	28					protein destabilization	mitochondrion|nucleus	catalytic activity|protein binding			ovary(1)	1	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0535)		ATGTTGTGGCGGAACTTCTCC	0.493			NA											19	107	---	---	---	---	NA	NA	NA	NA	NA
DARS	1615	broad.mit.edu	37	2	136680448	136680449	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr2:136680448_136680449insT	uc002tux.1	-	9	900_901	c.716_717insA	c.(715-717)TATfs	p.Y239fs	DARS_uc010fnj.1_Frame_Shift_Ins_p.Y139fs	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	239					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	TATTTTTAAAATATGACACAGT	0.337			NA											7	71	---	---	---	---	NA	NA	NA	NA	NA
CHRNA9	55584	broad.mit.edu	37	4	40337967	40337967	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr4:40337967delC	uc003gva.1	+	2	204	c.188delC	c.(187-189)ACGfs	p.T63fs		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	63	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	CTGCAGATTACGCTCTCTCAG	0.388	Esophageal Squamous(115;1297 1602 22235 25158 43327)		NA											23	133	---	---	---	---	NA	NA	NA	NA	NA
C7orf52	375607	broad.mit.edu	37	7	100815599	100815599	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:100815599delC	uc003uxy.1	-	4	1110	c.871delG	c.(871-873)GACfs	p.D291fs	C7orf52_uc003uxz.1_Frame_Shift_Del_p.D291fs	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	291							N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					CAAGTGCCGTCCCCTCCGTGC	0.736			NA											9	15	---	---	---	---	NA	NA	NA	NA	NA
EMID2	136227	broad.mit.edu	37	7	101200670	101200671	+	Frame_Shift_Ins	INS	-	-	T	rs67335052		TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:101200670_101200671insT	uc010lhy.1	+	14	1372_1373	c.1180_1181insT	c.(1180-1182)GGAfs	p.G394fs	EMID2_uc003uyo.1_Frame_Shift_Ins_p.E395fs	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	396						collagen				ovary(1)	1	Lung NSC(181;0.215)					CCTCCCCAGAGGAGGTTCTGGC	0.609			NA											7	47	---	---	---	---	NA	NA	NA	NA	NA
MLL5	55904	broad.mit.edu	37	7	104753135	104753136	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr7:104753135_104753136delGA	uc003vcm.2	+	27	5466_5467	c.4932_4933delGA	c.(4930-4935)CCGAATfs	p.P1644fs	MLL5_uc010ljc.2_Frame_Shift_Del_p.P1644fs|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Frame_Shift_Del_p.P378fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1644_1645	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TACAACAGCCGAATTCCCATCA	0.554			NA											17	105	---	---	---	---	NA	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113697722	113697722	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7576-01A-11D-2063-08	TCGA-55-7576-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c8e60b5b-1c41-426f-90a8-b63c97124d04	ce851db4-b8ff-4b99-9474-f9e393d89791	g.chr8:113697722delG	uc003ynu.2	-	15	2554	c.2395delC	c.(2395-2397)CATfs	p.H799fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.H71fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.H759fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.H695fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	799	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTAGTAAGATGGGAAGGCACC	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	112	---	---	---	---	NA	NA	NA	NA	NA
