Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6206324	6206324	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:6206324G>A	uc001amb.1	-	11	1850	c.1750C>T	c.(1750-1752)CGC>TGC	p.R584C	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	584					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ATGCCATAGCGGTAGAAGCGC	0.607			NA											17	42					0	0	0.010504	0	0
PER3	8863	broad.mit.edu	37	1	7880542	7880542	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:7880542C>T	uc001aoo.2	+	15	1950	c.1775C>T	c.(1774-1776)CCA>CTA	p.P592L	PER3_uc009vmg.1_Missense_Mutation_p.P600L|PER3_uc009vmh.1_Missense_Mutation_p.P593L|PER3_uc001aop.2_Missense_Mutation_p.P600L|PER3_uc010nzw.1_Missense_Mutation_p.P281L	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	592	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCAAATCCCAGCCATACCT	0.458			NA											5	14					0	0	0.000602	0	0
EPS15	2060	broad.mit.edu	37	1	51829575	51829575	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:51829575C>G	uc001csq.1	-	23	2414	c.2322G>C	c.(2320-2322)AAG>AAC	p.K774N	EPS15_uc009vyz.1_Missense_Mutation_p.K640N|EPS15_uc001csp.3_Missense_Mutation_p.K460N	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	774	15 X 3 AA repeats of D-P-F.|Pro-rich.|SH3-binding.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						GAGTTCCGATCTTTGGTGGCA	0.448			NA	T	MLL	ALL								6	53					0	0	0.004482	0	0
DAB1	1600	broad.mit.edu	37	1	57537266	57537266	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:57537266C>T	uc001cys.1	-	8	1161	c.487G>A	c.(487-489)GAA>AAA	p.E163K	DAB1_uc001cyt.1_Missense_Mutation_p.E163K|DAB1_uc001cyq.1_Missense_Mutation_p.E163K|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Missense_Mutation_p.E163K|DAB1_uc009vzx.1_Missense_Mutation_p.E163K	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	163	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						TGCTTCAATTCATAAATGAGT	0.413			NA											5	17					0	0	0.000602	0	0
LRRC7	57554	broad.mit.edu	37	1	70493864	70493864	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:70493864A>G	uc001dep.2	+	16	1721	c.1691A>G	c.(1690-1692)AAC>AGC	p.N564S	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	564						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GTTGAAATAAACCTAAAACGA	0.328			NA											3	40					0	0	0.004672	0	0
LRRC7	57554	broad.mit.edu	37	1	70505431	70505431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:70505431G>A	uc001dep.2	+	19	3840	c.3810G>A	c.(3808-3810)TGG>TGA	p.W1270*	LRRC7_uc009wbg.2_Nonsense_Mutation_p.W554*|LRRC7_uc001deq.2_Nonsense_Mutation_p.W511*	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1270						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CTGCAGACTGGAGACAACAGC	0.448			NA											9	74					0	0	0.010729	0	0
C1orf173	127254	broad.mit.edu	37	1	75036931	75036931	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:75036931G>T	uc001dgg.2	-	14	4682	c.4463C>A	c.(4462-4464)CCG>CAG	p.P1488Q		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1488	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TAGACTCTCCGGACTCAATTC	0.537			NA											26	86					5.77227e-19	7.65263e-19	0.008361	1	0
PTGFR	5737	broad.mit.edu	37	1	78959092	78959092	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:78959092A>G	uc001din.2	+	2	930	c.664A>G	c.(664-666)ATC>GTC	p.I222V	PTGFR_uc001dim.2_Missense_Mutation_p.I222V	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	222	Helical; Name=5; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GTGCAATGCAATCACAGGAAT	0.383			NA											9	16					0	0	0.004482	0	0
CLCA4	22802	broad.mit.edu	37	1	87031096	87031096	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:87031096G>A	uc009wcs.2	+	5	741	c.697G>A	c.(697-699)GAA>AAA	p.E233K	CLCA4_uc009wct.2_5'UTR|CLCA4_uc009wcu.2_Missense_Mutation_p.E53K	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	233						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGTACAAACAGAAAAAGCATC	0.318			NA											4	60					0	0	0.000602	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179620	90179620	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:90179620C>T	uc001dnl.3	+	3	1733	c.1491C>T	c.(1489-1491)AGC>AGT	p.S497S		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	497	LRR 5.					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		AGGTCTTGAGCGTCAAGTTTG	0.488			NA											5	17					0	0	0.001984	0	0
CCDC18	343099	broad.mit.edu	37	1	93687224	93687224	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:93687224C>T	uc001dpq.2	+	15	2543	c.2375C>T	c.(2374-2376)TCC>TTC	p.S792F	CCDC18_uc009wdl.1_Missense_Mutation_p.S309F	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	673	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAGACTATGTCCATGTTGCAA	0.303			NA											23	66					0	0	0.005443	0	0
LPPR4	9890	broad.mit.edu	37	1	99771530	99771530	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:99771530G>A	uc001dse.2	+	7	1362	c.1256G>A	c.(1255-1257)CGA>CAA	p.R419Q	LPPR4_uc010oue.1_Missense_Mutation_p.R361Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	419							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ACCTTGCCGCGAGCCAATACC	0.498			NA											5	45					0	0	0.000602	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110033961	110033961	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:110033961A>G	uc001dxr.2	+	10	1791	c.1776A>G	c.(1774-1776)AAA>AAG	p.K592K	ATXN7L2_uc001dxs.2_Silent_p.K219K|ATXN7L2_uc001dxt.2_Silent_p.K95K|CYB561D1_uc010ovl.1_5'Flank|CYB561D1_uc010ovm.1_5'Flank|CYB561D1_uc001dxu.2_5'Flank|CYB561D1_uc001dxw.2_5'Flank|CYB561D1_uc010ovn.1_5'Flank|CYB561D1_uc010ovo.1_5'Flank|CYB561D1_uc009wfd.2_5'Flank|CYB561D1_uc010ovp.1_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	592										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCACTGGAAAAGGGAAACCCT	0.597			NA											3	60					0	0	0.009096	0	0
PDIA3P	171423	broad.mit.edu	37	1	146650815	146650815	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:146650815G>C	uc001epg.1	+	1	1386	c.1123G>C	c.(1123-1125)GAT>CAT	p.D375H		NR_002305				SubName: Full=cDNA FLJ53558, highly similar to Protein disulfide-isomerase A3 (EC 5.3.4.1);												0						AGAGAGCAATGATGGGCCTGT	0.428			NA											6	56					0	0	0.004482	0	0
GJA8	2703	broad.mit.edu	37	1	147380681	147380681	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:147380681C>A	uc001epu.1	+	2	662	c.599C>A	c.(598-600)ACG>AAG	p.T200K		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	200	Extracellular (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TCCCGGCCCACGGAGAAAACC	0.607	Melanoma(76;1255 1795 8195 52096)		NA											16	70					1.15088e-07	1.33823e-07	0.004007	1	0
SV2A	9900	broad.mit.edu	37	1	149884960	149884960	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:149884960G>A	uc001etg.2	-	2	924	c.433C>T	c.(433-435)CGA>TGA	p.R145*	SV2A_uc001eth.2_Nonsense_Mutation_p.R145*	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	145	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	AGTTCTTCTCGTTCTTTCCGT	0.637			NA											3	40					0	0	0.009096	0	0
LENEP	55891	broad.mit.edu	37	1	154966094	154966094	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:154966094G>A	uc001fgi.2	+	1	33	c.11G>A	c.(10-12)CGG>CAG	p.R4Q		NM_018655	NP_061125	Q9Y5L5	LENEP_HUMAN	lens epithelial protein	4					multicellular organismal development		DNA binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ATGCAGCCCCGGACACAGCCC	0.612			NA											3	158					0	0	0.009096	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020194	156020194	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:156020194G>A	uc001fna.2	-	4	653	c.629C>T	c.(628-630)TCT>TTT	p.S210F	UBQLN4_uc010pgx.1_Missense_Mutation_p.S190F	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	210						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					ATCAGGGTTAGACATCATATC	0.522			NA											5	231					0	0	0.001168	0	0
OR10K1	391109	broad.mit.edu	37	1	158435910	158435910	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:158435910C>A	uc010pij.1	+	1	559	c.559C>A	c.(559-561)CTG>ATG	p.L187M		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGTCCTTAAACTGGCATCTCA	0.507			NA											105	130					8.83409e-43	1.1892e-42	0.01441	1	0
LRRC52	440699	broad.mit.edu	37	1	165514004	165514004	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:165514004C>T	uc001gde.2	+	1	527	c.471C>T	c.(469-471)CTC>CTT	p.L157L	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	157	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					ACCTGGACCTCAGAAATACCG	0.522			NA											12	118					0	0	0.003163	0	0
NPL	80896	broad.mit.edu	37	1	182787814	182787814	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:182787814G>T	uc009wyb.2	+	9	736	c.596G>T	c.(595-597)GGG>GTG	p.G199V	NPL_uc010pnx.1_Missense_Mutation_p.G180V|NPL_uc010pny.1_Intron|NPL_uc001gpo.1_Missense_Mutation_p.G180V|NPL_uc009wyc.2_Missense_Mutation_p.G199V|NPL_uc001gpp.3_Missense_Mutation_p.G199V|NPL_uc001gpq.1_Missense_Mutation_p.G199V	NM_030769	NP_110396	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase	199					carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TTCCTTTTTGGGGTGGATGAG	0.448			NA											11	29					0.00010058	0.000110009	0.013537	1	0
DHX9	1660	broad.mit.edu	37	1	182827742	182827742	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:182827742C>G	uc001gpr.2	+	9	1030	c.867C>G	c.(865-867)ATC>ATG	p.I289M	DHX9_uc001gps.2_Missense_Mutation_p.I75M	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	289	Interaction with BRCA1.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TGCAAAACATCATTCAAGAGC	0.373	Colon(69;210 1162 3697 13559 39565)		NA											6	43					0	0	0.001984	0	0
HMCN1	83872	broad.mit.edu	37	1	186147872	186147872	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:186147872C>T	uc001grq.1	+	104	16497	c.16268C>T	c.(16267-16269)TCT>TTT	p.S5423F	HMCN1_uc001grs.1_Intron	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5423					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCTGAAGGCTCTGAGGCAAGC	0.443			NA											4	70					0	0	0.009096	0	0
LGR6	59352	broad.mit.edu	37	1	202287921	202287921	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:202287921C>T	uc001gxu.2	+	18	2490	c.2490C>T	c.(2488-2490)TTC>TTT	p.F830F	LGR6_uc001gxv.2_Silent_p.F778F|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.F691F	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	830	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						ACCTGCTCTTCAACCCCCACT	0.677			NA											25	225					0	0	0.013726	0	0
PLXNA2	5362	broad.mit.edu	37	1	208224761	208224761	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:208224761T>C	uc001hgz.2	-	16	3759	c.3001A>G	c.(3001-3003)ATG>GTG	p.M1001V		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1001	Extracellular (Potential).|IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ATCTCACTCATTGACCTCCTG	0.572			NA											4	29					0	0	0.000602	0	0
USH2A	7399	broad.mit.edu	37	1	216370038	216370038	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:216370038C>T	uc001hku.1	-	19	4495	c.4108G>A	c.(4108-4110)GTC>ATC	p.V1370I	USH2A_uc001hkv.2_Missense_Mutation_p.V1370I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1370	Extracellular (Potential).|Fibronectin type-III 4.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGGGAAAGACTGAAGGAGGG	0.368			NA								HNSCC(13;0.011)			10	21					0	0	0.013537	0	0
OBSCN	84033	broad.mit.edu	37	1	228401921	228401921	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:228401921C>T	uc009xez.1	+	4	1349	c.1305C>T	c.(1303-1305)GGC>GGT	p.G435G	OBSCN_uc001hsn.2_Silent_p.G435G|uc001hsm.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	435	Ig-like 5.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCGCGTGGGCGACACGGCTA	0.711			NA											11	119					0	0	0.010729	0	0
FAM89A	375061	broad.mit.edu	37	1	231155691	231155691	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:231155691C>T	uc001hui.2	-	2	511	c.473G>A	c.(472-474)AGG>AAG	p.R158K	FAM89A_uc009xfm.2_Missense_Mutation_p.R169K|MIR1182_hsa-mir-1182|MI0006275_5'Flank	NM_198552	NP_940954	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	158											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TCGGTCCCTCCTGTCGTGCAG	0.592			NA											17	48					0	0	0.00499	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232650057	232650057	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:232650057T>A	uc001hvg.2	-	1	1187	c.1029A>T	c.(1027-1029)GAA>GAT	p.E343D		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	343					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TAGCCATGGCTTCGTTGATAT	0.507			NA											7	66					0	0	0.004482	0	0
RYR2	6262	broad.mit.edu	37	1	237777588	237777588	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:237777588G>A	uc001hyl.1	+	37	5280	c.5160G>A	c.(5158-5160)ATG>ATA	p.M1720I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1720	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCAGGCTCATGATGAACAACG	0.522			NA											7	35					0	0	0.001984	0	0
OR2C3	81472	broad.mit.edu	37	1	247695307	247695307	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:247695307C>A	uc009xgy.2	-	2	869	c.507G>T	c.(505-507)CTG>CTT	p.L169L	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGTTCCCACACAGCGGTAGGA	0.552			NA											8	16					0.00307968	0.00321758	0.00308	1	0
OR2G3	81469	broad.mit.edu	37	1	247769700	247769700	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:247769700G>A	uc010pyz.1	+	1	813	c.813G>A	c.(811-813)GGG>GGA	p.G271G		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGGACCAAGGGAAGTTTATCT	0.453			NA											19	21					0	0	0.008871	0	0
OR1C1	26188	broad.mit.edu	37	1	247921358	247921358	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:247921358C>T	uc010pza.1	-	1	351	c.351G>A	c.(349-351)GTG>GTA	p.V117V		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CATACGCCATCACACACAGAA	0.488			NA											7	51					0	0	0.001984	0	0
OR2T6	254879	broad.mit.edu	37	1	248551522	248551522	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr1:248551522G>T	uc001iei.1	+	1	613	c.613G>T	c.(613-615)GCA>TCA	p.A205S		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGCTGCGTTGCAATGCTGCT	0.512			NA											38	58					3.61848e-18	4.74332e-18	0.007835	1	0
NET1	10276	broad.mit.edu	37	10	5468684	5468685	+	Splice_Site	DNP	GG	GG	TT			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:5468684_5468685GG>TT	uc001iia.2	+	2	333	c.195_splice	c.e2+1	p.L65_splice	NET1_uc010qar.1_Splice_Site	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						ACTTCACTTTGGTGAGTAGATA	0.406			NA											13	31					0	0	0.004672	0	0
PRPF18	8559	broad.mit.edu	37	10	13672265	13672265	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:13672265G>T	uc001imp.2	+	10	1102	c.954G>T	c.(952-954)TTG>TTT	p.L318F	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	318					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						CTTAGGGATTGAAGAGGTTAA	0.264			NA											23	54					6.32553e-13	7.99255e-13	0.004656	1	0
GPR158	57512	broad.mit.edu	37	10	25885719	25885719	+	Splice_Site	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:25885719G>A	uc001isj.2	+	10	2205	c.2145_splice	c.e10+1	p.R715_splice	GPR158_uc001isk.2_Splice_Site_p.R90_splice	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor							integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GGACATTCGGGTAATGCCAGT	0.483			NA											12	66					0	0	0.00245	0	0
ANKRD26	22852	broad.mit.edu	37	10	27368065	27368065	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:27368065C>T	uc001ith.2	-	7	938	c.766G>A	c.(766-768)GAT>AAT	p.D256N	ANKRD26_uc001itg.2_5'UTR|ANKRD26_uc009xku.1_Missense_Mutation_p.D256N	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	256						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GGCCATGAATCATCAACACCC	0.333			NA											15	47					0	0	0.010504	0	0
PCDH15	65217	broad.mit.edu	37	10	55700715	55700715	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:55700715A>G	uc001jju.1	-	24	3538	c.3143T>C	c.(3142-3144)CTT>CCT	p.L1048P	PCDH15_uc010qhq.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhr.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhs.1_Missense_Mutation_p.L1060P|PCDH15_uc010qht.1_Missense_Mutation_p.L1055P|PCDH15_uc010qhu.1_Missense_Mutation_p.L1048P|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhw.1_Missense_Mutation_p.L1011P|PCDH15_uc010qhx.1_Missense_Mutation_p.L977P|PCDH15_uc010qhy.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhz.1_Missense_Mutation_p.L1048P|PCDH15_uc010qia.1_Missense_Mutation_p.L1026P|PCDH15_uc010qib.1_Missense_Mutation_p.L1026P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1048	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTGGTGGCAAGTTCACTTAC	0.308			NA								HNSCC(58;0.16)			15	22					0	0	0.00499	0	0
PCDH15	65217	broad.mit.edu	37	10	55892662	55892662	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:55892662C>A	uc001jju.1	-	15	2285	c.1890G>T	c.(1888-1890)AGG>AGT	p.R630S	PCDH15_uc010qhq.1_Missense_Mutation_p.R635S|PCDH15_uc010qhr.1_Missense_Mutation_p.R630S|PCDH15_uc010qhs.1_Missense_Mutation_p.R642S|PCDH15_uc010qht.1_Missense_Mutation_p.R637S|PCDH15_uc010qhu.1_Missense_Mutation_p.R630S|PCDH15_uc001jjv.1_Missense_Mutation_p.R608S|PCDH15_uc010qhv.1_Missense_Mutation_p.R630S|PCDH15_uc010qhw.1_Missense_Mutation_p.R593S|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Missense_Mutation_p.R635S|PCDH15_uc010qhz.1_Missense_Mutation_p.R630S|PCDH15_uc010qia.1_Missense_Mutation_p.R608S|PCDH15_uc010qib.1_Missense_Mutation_p.R608S|PCDH15_uc001jjw.2_Missense_Mutation_p.R630S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	630	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CAGCACCAACCCTCATGGCTT	0.353			NA								HNSCC(58;0.16)			12	14					7.03913e-09	8.29527e-09	0.013537	1	0
EGR2	1959	broad.mit.edu	37	10	64573782	64573782	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:64573782G>A	uc010qim.1	-	3	770	c.616C>T	c.(616-618)CCT>TCT	p.P206S	EGR2_uc010qin.1_Missense_Mutation_p.P156S|EGR2_uc001jmi.2_Missense_Mutation_p.P206S|EGR2_uc010qio.1_Missense_Mutation_p.P219S|EGR2_uc009xph.2_Missense_Mutation_p.P206S	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	206					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGATAGGAAGGAGGTGGTGGG	0.572			NA											17	69					0	0	0.012319	0	0
MYPN	84665	broad.mit.edu	37	10	69961617	69961617	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:69961617G>T	uc001jnm.3	+	19	3710	c.3525G>T	c.(3523-3525)CTG>CTT	p.L1175L	MYPN_uc001jnn.3_Silent_p.L900L|MYPN_uc001jno.3_Silent_p.L1175L|MYPN_uc009xpt.2_Silent_p.L1175L|MYPN_uc010qit.1_Silent_p.L881L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1175	Interaction with ACTN.|Ig-like 5.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CTGTGATCCTGGAGAAACTAC	0.413			NA											16	43					5.35267e-07	6.18295e-07	0.007413	1	0
PBLD	64081	broad.mit.edu	37	10	70056701	70056701	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:70056701C>T	uc001jns.1	-	3	329	c.126G>A	c.(124-126)ATG>ATA	p.M42I	PBLD_uc001jnr.1_Missense_Mutation_p.M9I|PBLD_uc001jnt.1_Missense_Mutation_p.M42I|PBLD_uc001jnu.1_Missense_Mutation_p.M42I|PBLD_uc001jnv.1_Missense_Mutation_p.M42I	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	42					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						CAGAGAGGTTCATCTCCCTTG	0.328			NA											26	65					0	0	0.012213	0	0
HK1	3098	broad.mit.edu	37	10	71144669	71144669	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:71144669G>A	uc001jpl.3	+	12	1938	c.1837G>A	c.(1837-1839)GCG>ACG	p.A613T	HK1_uc001jpg.3_Missense_Mutation_p.A601T|HK1_uc001jph.3_Missense_Mutation_p.A617T|HK1_uc001jpi.3_Missense_Mutation_p.A617T|HK1_uc001jpj.3_Missense_Mutation_p.A648T|HK1_uc001jpk.3_Missense_Mutation_p.A612T|HK1_uc009xqd.2_Missense_Mutation_p.A491T	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	613	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GAGTCTGGACGCGGTGAGTCT	0.592			NA											4	75					0	0	0.009096	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98412587	98412587	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:98412587C>A	uc001kmq.2	-	4	708	c.580G>T	c.(580-582)GTC>TTC	p.V194F	PIK3AP1_uc001kmp.2_Missense_Mutation_p.V16F	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	194	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		ATAACATAGACAGTGGTTTCT	0.547			NA											27	68					3.1745e-13	4.02563e-13	0.008361	1	0
ENTPD7	57089	broad.mit.edu	37	10	101458401	101458401	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:101458401G>A	uc001kqa.3	+	10	1299	c.1121G>A	c.(1120-1122)CGA>CAA	p.R374Q	ENTPD7_uc009xwl.2_Missense_Mutation_p.R376Q	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	374	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		TTACATGTCCGAGGAAGAGGA	0.562			NA											11	41					0	0	0.010729	0	0
PDCD11	22984	broad.mit.edu	37	10	105194595	105194595	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:105194595A>T	uc001kwy.1	+	25	3795	c.3708A>T	c.(3706-3708)CGA>CGT	p.R1236R		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1236	S1 motif 11.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CCATGGGCCGAGTGGTGAAGG	0.537			NA											4	23					0	0	0.000602	0	0
ATRNL1	26033	broad.mit.edu	37	10	116919926	116919926	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:116919926G>T	uc001lcg.2	+	6	1341	c.955G>T	c.(955-957)GTG>TTG	p.V319L	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.V319L|ATRNL1_uc009xyq.2_Missense_Mutation_p.V319L	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	319	Extracellular (Potential).|Kelch 1.					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATTTATGTGGGTGATTGGTGG	0.368			NA											19	67					1.40151e-16	1.81677e-16	0.010504	1	0
BUB3	9184	broad.mit.edu	37	10	124914503	124914503	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:124914503C>T	uc001lhe.2	+	2	312	c.70C>T	c.(70-72)CCC>TCC	p.P24S	BUB3_uc009yah.2_5'UTR|BUB3_uc001lhf.3_Missense_Mutation_p.P24S|BUB3_uc001lhd.2_Missense_Mutation_p.P24S|BUB3_uc010qud.1_Intron	NM_004725	NP_004716	O43684	BUB3_HUMAN	budding uninhibited by benzimidazoles 3 isoform	24	WD 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			ovary(1)	1		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				GAAGTTCAGCCCCAACACCTC	0.612	GBM(161;1111 1985 17553 20049 26037)		NA											26	108					0	0	0.00632	0	0
MKI67	4288	broad.mit.edu	37	10	129902974	129902974	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr10:129902974C>T	uc001lke.2	-	13	7325	c.7130G>A	c.(7129-7131)AGG>AAG	p.R2377K	MKI67_uc001lkf.2_Missense_Mutation_p.R2017K|MKI67_uc009yav.1_Missense_Mutation_p.R1952K|MKI67_uc009yaw.1_Missense_Mutation_p.R1527K	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2377	16 X 122 AA approximate repeats.|12.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGTTCGTTTCCTGAGTGCTAA	0.473			NA											58	166					0	0	0.01441	0	0
ABCC8	6833	broad.mit.edu	37	11	17464292	17464292	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:17464292G>C	uc001mnc.2	-	10	1731	c.1605C>G	c.(1603-1605)GCC>GCG	p.A535A	ABCC8_uc010rcy.1_Silent_p.A534A	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	535	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGATGGCAAAGGCCCTGAGGC	0.607			NA											4	44					0	0	0.009096	0	0
IGSF22	283284	broad.mit.edu	37	11	18731128	18731128	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:18731128T>C	uc009yht.2	-	18	2994	c.2804A>G	c.(2803-2805)TAC>TGC	p.Y935C	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	834	Fibronectin type-III 2.									ovary(4)|large_intestine(2)|kidney(1)	7						CTCAAGGATGTAGCCAGAGGG	0.587			NA											3	34					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	11	30974034	30974034	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:30974034A>T	uc009yjk.1	-	9	1086	c.1017T>A	c.(1015-1017)CTT>CTA	p.L339L	uc009yjl.1_Intron|DCDC1_uc001msu.1_Silent_p.L510L					RecName: Full=Doublecortin domain-containing protein 5;												NA						ACATGTAGGTAAGCTTGTTCC	0.423			NA											5	16					0	0	0.001168	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136708	40136708	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:40136708T>A	uc001mxa.1	-	2	3099	c.1135A>T	c.(1135-1137)ACA>TCA	p.T379S	LRRC4C_uc001mxc.1_Missense_Mutation_p.T375S|LRRC4C_uc001mxd.1_Missense_Mutation_p.T375S|LRRC4C_uc001mxb.1_Missense_Mutation_p.T375S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	379	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTCAGGGATGTGGAGGCCCGA	0.502			NA											17	62					0	0	0.00499	0	0
OR4A16	81327	broad.mit.edu	37	11	55110797	55110797	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:55110797C>A	uc010rie.1	+	1	121	c.121C>A	c.(121-123)CTC>ATC	p.L41I		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GGTGGGAAACCTCCTCATTTG	0.428			NA											13	58					1.5739e-10	1.893e-10	0.004007	1	0
OR5F1	338674	broad.mit.edu	37	11	55761300	55761300	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:55761300G>T	uc010riv.1	-	1	802	c.802C>A	c.(802-804)CTG>ATG	p.L268M		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TCCTGATTCAGGGAGTAGCTG	0.473			NA											20	46					5.35356e-11	6.46119e-11	0.00278	1	0
ESRRA	2101	broad.mit.edu	37	11	64074874	64074874	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:64074874C>T	uc001nzq.1	+	2	400	c.223C>T	c.(223-225)CCC>TCC	p.P75S	ESRRA_uc001nzr.1_Missense_Mutation_p.P75S|ESRRA_uc001nzs.1_Missense_Mutation_p.P75S	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	75	Repressor domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						CAGCTCCCTGCCCAAGCGCCT	0.657			NA											2	17					0	0	0.009096	0	0
CDCA5	113130	broad.mit.edu	37	11	64850855	64850855	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:64850855G>A	uc001ocp.2	-	4	389	c.224C>T	c.(223-225)TCA>TTA	p.S75L	ZFPL1_uc009yqa.2_5'Flank|ZFPL1_uc001ocq.1_5'Flank|ZFPL1_uc010rnx.1_5'Flank	NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	75					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						CCTGCGAGGTGATTGGACAGC	0.507			NA											4	45					0	0	0.009096	0	0
POLA2	23649	broad.mit.edu	37	11	65055233	65055233	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:65055233A>T	uc001odj.2	+	11	1395	c.1053A>T	c.(1051-1053)ACA>ACT	p.T351T	POLA2_uc010rod.1_Silent_p.T143T|POLA2_uc001odk.2_Silent_p.T48T	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	351					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	CATACACCACATCTGACAGCA	0.493			NA											6	50					0	0	0.00308	0	0
CCDC87	55231	broad.mit.edu	37	11	66358060	66358060	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:66358060C>T	uc001oiq.3	-	1	2495	c.2427G>A	c.(2425-2427)ATG>ATA	p.M809I	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	809										ovary(1)|skin(1)	2						TGTCACTCTTCATCTTGTCCA	0.537			NA											5	249					0	0	0.001168	0	0
INTS4	92105	broad.mit.edu	37	11	77705651	77705651	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:77705651G>C	uc001oys.2	-	1	67	c.39C>G	c.(37-39)TTC>TTG	p.F13L	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.F13L|INTS4_uc001oyv.1_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	13					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CCACTTTCGTGAATTCCTCAT	0.582			NA											12	86					0	0	0.00245	0	0
NOX4	50507	broad.mit.edu	37	11	89088169	89088169	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:89088169G>T	uc001pct.2	-	13	1417	c.1178C>A	c.(1177-1179)TCC>TAC	p.S393Y	NOX4_uc009yvr.2_Missense_Mutation_p.S368Y|NOX4_uc001pcu.2_Missense_Mutation_p.S319Y|NOX4_uc001pcw.2_Missense_Mutation_p.S86Y|NOX4_uc001pcx.2_Missense_Mutation_p.S86Y|NOX4_uc001pcv.2_Missense_Mutation_p.S393Y|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.S227Y|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Missense_Mutation_p.S369Y|NOX4_uc009yvq.2_Missense_Mutation_p.S369Y	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	393	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CAGAATTTCGGAGTCTTGACT	0.368			NA											5	12					0.00198382	0.00209137	0.001984	1	0
NAALAD2	10003	broad.mit.edu	37	11	89885504	89885504	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:89885504C>A	uc001pdf.3	+	6	757	c.648C>A	c.(646-648)ATC>ATA	p.I216I	NAALAD2_uc009yvx.2_Silent_p.I216I|NAALAD2_uc009yvy.2_Silent_p.I216I|NAALAD2_uc001pdd.2_Silent_p.I216I|NAALAD2_uc001pde.2_Silent_p.I216I	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	216	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TAGGAATCATCTTGTACTCAG	0.438			NA											6	34					0.00307968	0.00321758	0.00308	1	0
CNTN5	53942	broad.mit.edu	37	11	100211914	100211914	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:100211914G>A	uc001pga.2	+	23	3346	c.3007G>A	c.(3007-3009)GAA>AAA	p.E1003K	CNTN5_uc001pgb.2_Missense_Mutation_p.E929K|CNTN5_uc010ruk.1_Missense_Mutation_p.E274K	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	1003	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATTAGCCAACGAATCTGAAGT	0.433			NA											21	58					0	0	0.00333	0	0
PGR	5241	broad.mit.edu	37	11	100999577	100999577	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:100999577C>A	uc001pgh.2	-	1	968	c.225G>T	c.(223-225)CAG>CAT	p.Q75H	PGR_uc001pgi.2_Missense_Mutation_p.Q75H|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	75	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ACTGCTGGTCCTGCGTCTTTT	0.612	Pancreas(124;2271 2354 21954 22882)		NA											8	19					0.000274275	0.000298125	0.004482	1	0
NCAM1	4684	broad.mit.edu	37	11	113103043	113103043	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:113103043G>C	uc009yyq.1	+	12	1810	c.1116G>C	c.(1114-1116)AAG>AAC	p.K372N		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	464	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCAATATCAAGATCTACAACA	0.527			NA											10	51					0	0	0.004007	0	0
BUD13	84811	broad.mit.edu	37	11	116633454	116633454	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:116633454C>G	uc001ppn.2	-	4	885	c.851G>C	c.(850-852)AGA>ACA	p.R284T	BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Missense_Mutation_p.R284T	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	284										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ACTTTTGGTTCTGGGCAGGGA	0.498			NA											10	72					0	0	0.006214	0	0
ZNF202	7753	broad.mit.edu	37	11	123601409	123601409	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:123601409G>C	uc001pzd.1	-	4	588	c.188C>G	c.(187-189)GCT>GGT	p.A63G	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Missense_Mutation_p.A63G|ZNF202_uc001pzf.1_Missense_Mutation_p.A63G	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	63	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCTGATGAGAGCTTCTCTAGG	0.557			NA											7	35					0	0	0.001984	0	0
OR6X1	390260	broad.mit.edu	37	11	123625181	123625181	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr11:123625181G>T	uc010rzy.1	-	1	46	c.46C>A	c.(46-48)CCT>ACT	p.P16T		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGATAACAGGAAAGCCTAGC	0.433			NA											12	70					2.62699e-14	3.34344e-14	0.003163	1	0
C1RL	51279	broad.mit.edu	37	12	7249397	7249397	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:7249397C>A	uc001qsn.2	-	6	1071	c.1054G>T	c.(1054-1056)GGC>TGC	p.G352C	C1RL_uc009zft.2_3'UTR	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	352	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						ACGTTGGGGCCCAGGGGGATG	0.612			NA											4	31					0.000602214	0.000642607	0.000602	1	0
PHC1	1911	broad.mit.edu	37	12	9074263	9074263	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:9074263G>C	uc001qvd.2	+	5	529	c.373G>C	c.(373-375)GCT>CCT	p.A125P	PHC1_uc001qvc.1_Missense_Mutation_p.A88P|PHC1_uc010sgn.1_Missense_Mutation_p.A125P|PHC1_uc001qve.2_Missense_Mutation_p.A125P	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	125					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CTCTCCCAGTGCTACCACCTT	0.567			NA											4	40					0	0	0.001168	0	0
CLEC1B	51266	broad.mit.edu	37	12	10150953	10150953	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:10150953G>C	uc001qwu.2	-	2	291	c.91C>G	c.(91-93)CGT>GGT	p.R31G	CLEC1B_uc009zhd.2_Intron	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	31	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						GCCATCACACGCCACCAGGAG	0.532			NA											34	61					0	0	0.00623	0	0
ARHGDIB	397	broad.mit.edu	37	12	15095501	15095501	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:15095501G>A	uc001rcq.1	-	6	665	c.561C>T	c.(559-561)CTC>CTT	p.L187L	ARHGDIB_uc001rcp.1_RNA	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	187					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						ACTCCCAGCTGAGGTGGTCTT	0.552			NA											12	84					0	0	0.003163	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919149	21919149	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:21919149C>T	uc001rff.2	-	3	1121	c.783G>A	c.(781-783)CTG>CTA	p.L261L		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	261	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	AAGGGGCCACCAGAAAAATGT	0.478			NA											7	9					0	0	0.00308	0	0
DNAJC22	79962	broad.mit.edu	37	12	49742929	49742929	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:49742929G>T	uc001rua.2	+	2	675	c.274G>T	c.(274-276)GGC>TGC	p.G92C	DNAJC22_uc001rub.2_Missense_Mutation_p.G92C	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	92	Helical; (Potential).				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						CATCTATTTTGGCCTTGTGGC	0.567			NA											30	71					9.78485e-24	1.30714e-23	0.013726	1	0
OR6C6	283365	broad.mit.edu	37	12	55688659	55688659	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:55688659G>A	uc010sph.1	-	1	358	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						GCAACGTAGCGGTCATAGGAC	0.393			NA											10	16					0	0	0.013537	0	0
R3HDM2	22864	broad.mit.edu	37	12	57648586	57648586	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:57648586C>A	uc009zpm.1	-	22	2936	c.2901G>T	c.(2899-2901)CTG>CTT	p.L967L	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Silent_p.L662L|R3HDM2_uc001snr.2_Silent_p.L694L|R3HDM2_uc001sns.2_Silent_p.L967L|R3HDM2_uc001snt.2_Silent_p.L981L|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	967						nucleus	nucleic acid binding			ovary(2)	2						CCAGGATCCTCAGGTCATAGT	0.557			NA											5	29					0.00198382	0.00209137	0.001984	1	0
RAP1B	5908	broad.mit.edu	37	12	69050962	69050962	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:69050962C>T	uc001sub.2	+	7	713	c.550C>T	c.(550-552)CTT>TTT	p.L184F	RAP1B_uc010ste.1_Missense_Mutation_p.L118F|RAP1B_uc001suc.2_Missense_Mutation_p.L184F|RAP1B_uc010stf.1_Missense_Mutation_p.L165F|RAP1B_uc010stg.1_Missense_Mutation_p.L142F|RAP1B_uc010sth.1_Missense_Mutation_p.L142F|RAP1B_uc010sti.1_Missense_Mutation_p.L137F	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	184					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		ATGTCAGCTGCTTTAATATAC	0.383			NA											21	30					0	0	0.00333	0	0
FRS2	10818	broad.mit.edu	37	12	69962837	69962837	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:69962837T>A	uc001suy.2	+	6	537	c.27T>A	c.(25-27)GAT>GAA	p.D9E	FRS2_uc001suz.2_Missense_Mutation_p.D9E|FRS2_uc009zrj.2_Missense_Mutation_p.D9E|FRS2_uc009zrk.2_Missense_Mutation_p.D9E	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	9					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GCTGTCCAGATAAAGACACTG	0.363			NA											9	22					0	0	0.010729	0	0
NAV3	89795	broad.mit.edu	37	12	78388619	78388619	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:78388619T>A	uc001syp.2	+	6	881	c.708T>A	c.(706-708)AGT>AGA	p.S236R	NAV3_uc001syo.2_Missense_Mutation_p.S236R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	236						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTAATCACAGTGGAATTGCAA	0.348			NA								HNSCC(70;0.22)			12	23					0	0	0.004007	0	0
SCYL2	55681	broad.mit.edu	37	12	100723039	100723039	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:100723039G>T	uc001thn.2	+	13	1753	c.1703G>T	c.(1702-1704)GGA>GTA	p.G568V	SCYL2_uc001thm.1_Missense_Mutation_p.G568V	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	568					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						CAGCTGGCCGGAAAAGTGTTG	0.333			NA											17	26					3.8784e-16	5.00901e-16	0.012319	1	0
ACACB	32	broad.mit.edu	37	12	109614007	109614007	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:109614007G>A	uc001tob.2	+	9	1495	c.1376G>A	c.(1375-1377)GGC>GAC	p.G459D	ACACB_uc001toc.2_Missense_Mutation_p.G459D	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	459	Biotin carboxylation.|ATP-grasp.|ATP (Potential).				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TCTGAAGGTGGCGGAGGGAAG	0.493			NA											70	132					0	0	0.01441	0	0
RSRC2	65117	broad.mit.edu	37	12	122992965	122992965	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr12:122992965C>A	uc001ucr.2	-	8	981	c.835G>T	c.(835-837)GTT>TTT	p.V279F	RSRC2_uc001uco.2_Missense_Mutation_p.V48F|RSRC2_uc001ucp.2_Missense_Mutation_p.V220F|RSRC2_uc001ucq.2_Missense_Mutation_p.V47F|RSRC2_uc001ucs.2_Missense_Mutation_p.V48F|RSRC2_uc001uct.2_Missense_Mutation_p.V231F|RSRC2_uc001ucu.2_Missense_Mutation_p.V280F	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	279										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		AGGGCAGCAACATTGAGAACA	0.433			NA											3	12					6.4e-05	7.08861e-05	0.004672	1	0
STARD13	90627	broad.mit.edu	37	13	33703375	33703375	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr13:33703375T>C	uc001uuw.2	-	5	1565	c.1439A>G	c.(1438-1440)GAT>GGT	p.D480G	STARD13_uc001uuu.2_Missense_Mutation_p.D472G|STARD13_uc001uuv.2_Missense_Mutation_p.D362G|STARD13_uc001uux.2_Missense_Mutation_p.D445G|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.D465G	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GAAAAGGTCATCTTTCTCCAA	0.502			NA											27	31					0	0	0.007291	0	0
NBEA	26960	broad.mit.edu	37	13	35615154	35615154	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr13:35615154C>A	uc001uvb.2	+	3	585	c.379C>A	c.(379-381)CAC>AAC	p.H127N		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	127						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCTTTTGGAGCACTGTGATGT	0.393			NA											23	46					1.17739e-12	1.47702e-12	0.005443	1	0
NALCN	259232	broad.mit.edu	37	13	101717763	101717763	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr13:101717763C>T	uc001vox.1	-	40	4786	c.4597G>A	c.(4597-4599)GTC>ATC	p.V1533I		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1533	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TACCTCAGGACATCATGGAAG	0.542			NA											27	61					0	0	0.012213	0	0
CUL4A	8451	broad.mit.edu	37	13	113907459	113907459	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr13:113907459C>T	uc010tjy.1	+	17	1713	c.1702C>T	c.(1702-1704)CAG>TAG	p.Q568*	CUL4A_uc010tjx.1_Nonsense_Mutation_p.Q468*|CUL4A_uc010agu.2_Nonsense_Mutation_p.Q429*|CUL4A_uc010tjz.1_Nonsense_Mutation_p.Q247*	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	568					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TCGAAAACTTCAGTGGCAAAC	0.303			NA											14	42					0	0	0.00499	0	0
RNASE3	6037	broad.mit.edu	37	14	21359990	21359990	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:21359990C>G	uc001vyj.2	+	2	199	c.145C>G	c.(145-147)CGA>GGA	p.R49G		NM_002935	NP_002926	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3 (eosinophil	49					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	GAACCCCCCTCGATGCACCAT	0.478			NA											5	91					0	0	0.000602	0	0
LRP10	26020	broad.mit.edu	37	14	23344587	23344587	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:23344587G>A	uc001whd.2	+	5	983	c.430G>A	c.(430-432)GAG>AAG	p.E144K	LRP10_uc001whe.2_Missense_Mutation_p.E20K	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	144	LDL-receptor class A 1.|Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CCTGCAGGAAGAGTTTCAGTG	0.577			NA											13	72					0	0	0.006122	0	0
LTB4R	1241	broad.mit.edu	37	14	24785492	24785493	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:24785492_24785493GC>TT	uc001wos.2	+	2	956_957	c.635_636GC>TT	c.(634-636)CGC>CTT	p.R212L	LTB4R_uc010alp.2_Missense_Mutation_p.R212L|LTB4R_uc001wou.2_Missense_Mutation_p.R212L	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	212	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		CAGGCCCGGCGCTTCCGCCGCA	0.673			NA											4	14					0	0	0.004672	0	0
PRKD1	5587	broad.mit.edu	37	14	30194845	30194845	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:30194845C>T	uc001wqh.2	-	2	481	c.300G>A	c.(298-300)AAG>AAA	p.K100K		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	100					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AAAGCAGGATCTTATCATACA	0.393			NA											16	73					0	0	0.006122	0	0
HEATR5A	25938	broad.mit.edu	37	14	31771573	31771573	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:31771573C>G	uc001wrf.3	-	27	4590	c.4513G>C	c.(4513-4515)GAA>CAA	p.E1505Q	HEATR5A_uc010ami.2_Intron	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1792							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CGGCTCTTTTCTGCCCGGGCC	0.483			NA											5	14					0	0	0.001168	0	0
LRFN5	145581	broad.mit.edu	37	14	42356780	42356780	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:42356780A>C	uc001wvm.2	+	3	2150	c.952A>C	c.(952-954)ATT>CTT	p.I318L	LRFN5_uc010ana.2_Missense_Mutation_p.I318L	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	318	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGAGCCTGCAATTCACTGGAT	0.463			NA								HNSCC(30;0.082)			4	104					0	0	0.000602	0	0
ADAM20	8748	broad.mit.edu	37	14	70991355	70991355	+	Silent	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:70991355T>C	uc001xme.2	-	2	515	c.270A>G	c.(268-270)CCA>CCG	p.P90P		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	40					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCACCACTTCTGGAGAAGTGA	0.532			NA											5	22					0	0	0.001168	0	0
C14orf174	161394	broad.mit.edu	37	14	77844488	77844488	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr14:77844488G>A	uc001xtq.1	+	1	727	c.727G>A	c.(727-729)GAG>AAG	p.E243K	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	243											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GACTCCAGAGGAGACACAAAG	0.468			NA											7	23					0	0	0.001984	0	0
TYRO3	7301	broad.mit.edu	37	15	41870191	41870191	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr15:41870191C>T	uc001zof.1	+	19	2614	c.2390C>T	c.(2389-2391)TCT>TTT	p.S797F		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	797	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TCTGTGCTATCTGCCAGCCAG	0.587			NA											6	27					0	0	0.001984	0	0
SLC30A4	7782	broad.mit.edu	37	15	45803358	45803358	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr15:45803358G>A	uc001zvj.2	-	3	828	c.516C>T	c.(514-516)TTC>TTT	p.F172F	C15orf21_uc001zvk.2_RNA|C15orf21_uc010beg.1_RNA|C15orf21_uc010beh.1_RNA|C15orf21_uc010bei.1_RNA|C15orf21_uc010bej.1_RNA|C15orf21_uc001zvm.1_RNA|C15orf21_uc001zvn.1_RNA	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	172	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		ATCCAAAGGTGAATCTTTTGG	0.368			NA											9	156					0	0	0.008291	0	0
UACA	55075	broad.mit.edu	37	15	70976696	70976696	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr15:70976696G>A	uc002asr.2	-	8	796	c.692C>T	c.(691-693)GCG>GTG	p.A231V	UACA_uc010uke.1_Intron|UACA_uc002asq.2_Missense_Mutation_p.A218V|UACA_uc010bin.1_Missense_Mutation_p.A217V	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	231						cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						ATGGCCAAGCGCATCCAGCAA	0.408			NA											29	68					0	0	0.012213	0	0
PIGQ	9091	broad.mit.edu	37	16	633139	633139	+	Silent	SNP	G	G	A	rs150021665	byFrequency	TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:633139G>A	uc002cho.2	+	10	1890	c.1788G>A	c.(1786-1788)ACG>ACA	p.T596T	PIGQ_uc010bqw.2_3'UTR|PIGQ_uc002chn.2_3'UTR|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Silent_p.T166T|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	596					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				CTTTGTGGACGCTGCTGTGTG	0.647			NA											10	83					0	0	0.013537	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261984	1261984	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:1261984C>T	uc002cks.2	+	25	4853	c.4605C>T	c.(4603-4605)TTC>TTT	p.F1535F	CACNA1H_uc002ckt.2_Silent_p.F1535F|CACNA1H_uc002cku.2_Silent_p.F241F|CACNA1H_uc010brj.2_Silent_p.F241F|CACNA1H_uc002ckv.2_Silent_p.F241F	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1535	Helical; Name=S6 of repeat III; (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGCTGTACTTCATCTCCTTCC	0.642			NA											13	228					0	0	0.00499	0	0
E4F1	1877	broad.mit.edu	37	16	2282276	2282276	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:2282276G>T	uc002cpm.2	+	4	568	c.520G>T	c.(520-522)GCA>TCA	p.A174S	E4F1_uc010bsi.2_Missense_Mutation_p.A174S|E4F1_uc010bsj.2_Missense_Mutation_p.A174S	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	174					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCTGGGGCTCGCAGGGGAGGG	0.667			NA											17	16					2.35188e-11	2.87818e-11	0.006122	1	0
CCDC64B	146439	broad.mit.edu	37	16	3078218	3078218	+	Silent	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:3078218C>G	uc002ctf.3	-	9	1461	c.1416G>C	c.(1414-1416)CTG>CTC	p.L472L	CCDC64B_uc002cte.3_Silent_p.L265L	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	472											0						CGGAGGCGCTCAGCTCCTTCT	0.736			NA											2	5					0	0	0.004672	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492237	20492237	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:20492237A>T	uc010bwe.2	+	13	1742	c.1503A>T	c.(1501-1503)CGA>CGT	p.R501R	ACSM2A_uc010vax.1_Silent_p.R422R|ACSM2A_uc002dhf.3_Silent_p.R501R|ACSM2A_uc002dhg.3_Silent_p.R501R|ACSM2A_uc010vay.1_Silent_p.R422R|ACSM2A_uc002dhh.3_Silent_p.R131R	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	501		Coenzyme A.			fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						ACCCCGTCCGAGGAGAGGTGA	0.443			NA											12	33					0	0	0.00245	0	0
ZP2	7783	broad.mit.edu	37	16	21213302	21213302	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:21213302G>C	uc002dii.2	-	12	1330	c.1330C>G	c.(1330-1332)CTC>GTC	p.L444V	ZP2_uc010bwn.1_Missense_Mutation_p.L483V	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	444	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		TCCGTCCAGAGAGCATGTATT	0.373			NA											8	65					0	0	0.004482	0	0
XPO6	23214	broad.mit.edu	37	16	28128693	28128693	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:28128693G>A	uc002dpa.1	-	15	2451	c.1950C>T	c.(1948-1950)TTC>TTT	p.F650F	XPO6_uc002dpb.1_Silent_p.F636F|XPO6_uc010vcp.1_Silent_p.F650F	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	650					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TGAGTGTCACGAACTGCTGCG	0.502			NA											15	107					0	0	0.00499	0	0
GNAO1	2775	broad.mit.edu	37	16	56226258	56226258	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:56226258C>A	uc002eit.3	+	1	1008	c.111C>A	c.(109-111)CTC>CTA	p.L37L	GNAO1_uc002eiu.3_Silent_p.L37L|LOC283856_uc002eis.1_5'Flank	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	37					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				TGAAATTACTCCTGCTCGGTA	0.662			NA											5	33					8.12818e-05	8.94611e-05	0.001984	1	0
NLRC5	84166	broad.mit.edu	37	16	57073730	57073730	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:57073730G>A	uc002ekk.1	+	16	3064	c.2839G>A	c.(2839-2841)GAG>AAG	p.E947K	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.E696K|NLRC5_uc002ekl.2_Missense_Mutation_p.E752K|NLRC5_uc002ekm.2_Missense_Mutation_p.E752K|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_5'Flank|NLRC5_uc002ekp.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	947	LRR 7.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GTTTGCCCAGGAGCCAGAGGA	0.537			NA											14	75					0	0	0.007413	0	0
LCAT	3931	broad.mit.edu	37	16	67974229	67974229	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:67974229C>T	uc002euy.1	-	6	912	c.901G>A	c.(901-903)GAC>AAC	p.D301N		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	301					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		CGTTGGAAGTCACGGCCTGTG	0.582			NA											3	58					0	0	0.004672	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482781	76482781	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:76482781C>A	uc002feu.1	+	8	1245	c.860C>A	c.(859-861)ACA>AAA	p.T287K	CNTNAP4_uc002fev.1_Missense_Mutation_p.T199K|CNTNAP4_uc010chb.1_Missense_Mutation_p.T262K|CNTNAP4_uc002fex.1_Missense_Mutation_p.T290K|CNTNAP4_uc002few.2_Missense_Mutation_p.T262K	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	287	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GTCAACTTCACAGTGGACGAA	0.458			NA											4	17					0.000602214	0.000642607	0.000602	1	0
DYNLRB2	83657	broad.mit.edu	37	16	80577179	80577179	+	Missense_Mutation	SNP	G	G	T	rs149421698	byFrequency	TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:80577179G>T	uc002ffo.2	+	4	130	c.10G>T	c.(10-12)GTG>TTG	p.V4L	DYNLRB2_uc002ffp.2_RNA|DYNLRB2_uc002ffq.2_RNA	NM_130897	NP_570967	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2	4					microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity				0						TCAGGCAGAGGTGGAGGAAAC	0.413			NA											13	39					0.000422831	0.000456762	0.004007	1	0
PKD1L2	114780	broad.mit.edu	37	16	81183335	81183335	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:81183335C>A	uc002fgh.1	-	28	4713	c.4713G>T	c.(4711-4713)TGG>TGT	p.W1571C	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1571	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGGGGACCCCCCAGAACATGA	0.597			NA											5	14					1.23904e-05	1.39442e-05	0.000602	1	0
PKD1L2	114780	broad.mit.edu	37	16	81214828	81214828	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:81214828G>C	uc002fgh.1	-	12	2046	c.2046C>G	c.(2044-2046)CTC>CTG	p.L682L	PKD1L2_uc002fgg.1_RNA|PKD1L2_uc002fgi.2_5'UTR|PKD1L2_uc002fgj.2_Silent_p.L682L|PKD1L2_uc002fgl.1_5'UTR	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	682	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGGTGACCCTGAGCAGAATGT	0.517			NA											13	60					0	0	0.004007	0	0
PRDM7	11105	broad.mit.edu	37	16	90130098	90130098	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr16:90130098C>A	uc010cje.2	-	5	450	c.430G>T	c.(430-432)GAC>TAC	p.D144Y	PRDM7_uc002fqo.2_5'Flank|PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjg.1_5'Flank|PRDM7_uc010cjh.1_Intron	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	144						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TGCTCTGAGTCACTTGTATTC	0.423			NA											15	20					3.51602e-12	4.39502e-12	0.008871	1	0
SMYD4	114826	broad.mit.edu	37	17	1686381	1686381	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:1686381T>C	uc002ftm.3	-	10	2377	c.2209A>G	c.(2209-2211)AGT>GGT	p.S737G	SMYD4_uc002ftn.1_Missense_Mutation_p.S592G	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	737							zinc ion binding			skin(3)|kidney(2)	5						ATTTCAACACTGGACGGCCCG	0.517			NA											13	23					0	0	0.001855	0	0
TP53	7157	broad.mit.edu	37	17	7579533	7579533	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:7579533G>A	uc002gim.2	-	4	348	c.154C>T	c.(154-156)CAA>TAA	p.Q52*	TP53_uc002gig.1_Nonsense_Mutation_p.Q52*|TP53_uc002gih.2_Nonsense_Mutation_p.Q52*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Q52*|TP53_uc010cni.1_Nonsense_Mutation_p.Q52*|TP53_uc002gij.2_Nonsense_Mutation_p.Q52*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.Q13*|TP53_uc010cnk.1_Nonsense_Mutation_p.Q67*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	52	TADII.|Interaction with HRMT1L2.		Q -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.Q52*(6)|p.Q52>P*(1)|p.Q52H(1)|p.E51fs*59(1)|p.I50fs*4(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.Q52fs*6(1)|p.E51_Q52insX(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGAACCATTGTTCAATATCG	0.582	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			61	97					0	0	0.01441	0	0
MAP2K3	5606	broad.mit.edu	37	17	21217498	21217498	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:21217498G>A	uc002gys.2	+	12	1265	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	MAP2K3_uc002gyt.2_Missense_Mutation_p.D305N|MAP2K3_uc002gyu.2_Missense_Mutation_p.D305N	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	334					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAAGAAGACGGACATTGCTGC	0.627			NA											57	386					0	0	0.01441	0	0
Unknown	0	broad.mit.edu	37	17	21730906	21730906	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:21730906G>C	uc002gyy.3	+	2	333	c.208G>C	c.(208-210)GTC>CTC	p.V70L						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						CCTGCATCTGGTCCTGCGTCG	0.552			NA											16	40					0	0	0.010504	0	0
ACLY	47	broad.mit.edu	37	17	40070111	40070111	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:40070111T>C	uc002hyg.2	-	2	179	c.16A>G	c.(16-18)ATT>GTT	p.I6V	ACLY_uc002hyh.2_Missense_Mutation_p.I6V|ACLY_uc002hyi.2_Missense_Mutation_p.I60V|ACLY_uc010wfx.1_Missense_Mutation_p.I60V|ACLY_uc010wfy.1_Missense_Mutation_p.I6V	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	6					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGCTCTGAAATTGCCTTGGCC	0.547	Colon(64;807 1396 15971 30971)		NA											14	127					0	0	0.006122	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40652901	40652901	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:40652901C>T	uc002hzr.2	+	16	2023	c.1856C>T	c.(1855-1857)TCC>TTC	p.S619F	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.S619F|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.S626F|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.S576F|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.S576F|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.S265F|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.S478F	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	619	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TTCCTCTTTTCCTACCCAGAG	0.428			NA											4	130					0	0	0.000602	0	0
C17orf53	78995	broad.mit.edu	37	17	42228409	42228409	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:42228409A>G	uc002ifi.1	+	4	1490	c.1305A>G	c.(1303-1305)ACA>ACG	p.T435T	C17orf53_uc010czq.1_Silent_p.T435T|C17orf53_uc002ifj.1_Intron|C17orf53_uc002ifk.1_Intron	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	435											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AATTCCAGACAGAGGTAACTT	0.502			NA											7	18					0	0	0.00308	0	0
GRN	2896	broad.mit.edu	37	17	42427843	42427843	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:42427843C>T	uc002igp.1	+	6	715	c.496C>T	c.(496-498)CCG>TCG	p.P166S	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'UTR	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	166					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCACTGCTGTCCGCACGGTGC	0.632			NA									OREG0024459	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	191					0	0	0.007291	0	0
KIF2B	84643	broad.mit.edu	37	17	51902313	51902313	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:51902313G>T	uc002iua.2	+	1	2075	c.1919G>T	c.(1918-1920)CGG>CTG	p.R640L	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	640	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TGCATTGCCCGGTCTTTGTCC	0.443			NA											19	28					1.22574e-08	1.43481e-08	0.014323	1	0
C17orf47	284083	broad.mit.edu	37	17	56621498	56621498	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:56621498C>G	uc002iwq.1	-	1	186	c.50G>C	c.(49-51)AGA>ACA	p.R17T		NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	17										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCAGACCCTCTCTGTGCTGA	0.517			NA											14	94					0	0	0.00245	0	0
INTS2	57508	broad.mit.edu	37	17	59972721	59972721	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:59972721C>G	uc002izn.2	-	12	1618	c.1542G>C	c.(1540-1542)TTG>TTC	p.L514F	INTS2_uc002izm.2_Missense_Mutation_p.L506F	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	514					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TCATCCTGCTCAAGGAGCTTG	0.289			NA											2	7					0	0	0.004672	0	0
SLC38A10	124565	broad.mit.edu	37	17	79246348	79246348	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:79246348C>T	uc002jzz.1	-	9	1367	c.992G>A	c.(991-993)GGA>GAA	p.G331E	SLC38A10_uc002jzy.1_Missense_Mutation_p.G249E|SLC38A10_uc002kab.2_Missense_Mutation_p.G331E	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	331	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AACCATGGTTCCAAACACCAC	0.557			NA											14	79					0	0	0.004007	0	0
FASN	2194	broad.mit.edu	37	17	80041265	80041265	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:80041265C>A	uc002kdu.2	-	32	5495	c.5378G>T	c.(5377-5379)GGG>GTG	p.G1793V	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1793	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CAGTAGGACCCCGTGGAATGT	0.647	Colon(59;314 1043 11189 28578 32273)		NA											10	21					9.31168e-06	1.05472e-05	0.001855	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14848862	14848862	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:14848862C>T	uc010dlo.2	+	34	3152	c.2972C>T	c.(2971-2973)GCG>GTG	p.A991V	ANKRD30B_uc010xal.1_Missense_Mutation_p.A133V	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1076	Potential.									ovary(1)|skin(1)	2						CTGTCAGAAGCGAAAGAAATA	0.328			NA											3	5					0	0	0.000602	0	0
C18orf34	374864	broad.mit.edu	37	18	30873179	30873179	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:30873179C>T	uc002kxn.2	-	11	1262	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K	C18orf34_uc010xbr.1_Missense_Mutation_p.E374K|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.E374K|C18orf34_uc002kxp.2_Missense_Mutation_p.E374K	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	374	Potential.									ovary(1)	1						CTTATTGCTTCAGTCACTTCC	0.279			NA											8	22					0	0	0.004482	0	0
SETBP1	26040	broad.mit.edu	37	18	42530277	42530277	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:42530277G>T	uc010dni.2	+	4	1268	c.972G>T	c.(970-972)GAG>GAT	p.E324D		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	324						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTACAAAGGAGCCCCCAGAAC	0.542			NA							Schinzel-Giedion_syndrome				9	25					7.48243e-07	8.61464e-07	0.006214	1	0
CXXC1	30827	broad.mit.edu	37	18	47809014	47809014	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:47809014C>T	uc002leq.3	-	15	2653	c.1920G>A	c.(1918-1920)ACG>ACA	p.T640T	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc010dox.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Silent_p.T497T|CXXC1_uc002ler.3_Silent_p.T644T|CXXC1_uc010doy.2_3'UTR	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	640					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGTGCTGGATCGTCTGGTGCA	0.642			NA											8	58					0	0	0.006214	0	0
BCL2	596	broad.mit.edu	37	18	60985347	60985347	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:60985347G>A	uc002lit.1	-	2	1046	c.553C>T	c.(553-555)CTG>TTG	p.L185L	BCL2_uc002liu.1_Silent_p.L185L|BCL2_uc002liv.1_Silent_p.L185L	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	185					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	CAGGTGTGCAGGTGCCGGTTC	0.612			NA	T	IGH@	NHL|CLL								9	36					0	0	0.013537	0	0
SERPINB7	8710	broad.mit.edu	37	18	61463530	61463530	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:61463530G>A	uc002ljl.2	+	5	463	c.367G>A	c.(367-369)GAT>AAT	p.D123N	SERPINB7_uc002ljm.2_Missense_Mutation_p.D123N|SERPINB7_uc010xet.1_Missense_Mutation_p.D106N|SERPINB7_uc010dqg.2_Missense_Mutation_p.D123N	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	123					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				AAAATTATACGATGCCAAAGT	0.318			NA											4	10					0	0	0.009096	0	0
SALL3	27164	broad.mit.edu	37	18	76755179	76755179	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:76755179T>C	uc002lmt.2	+	2	3188	c.3188T>C	c.(3187-3189)ATG>ACG	p.M1063T	SALL3_uc010dra.2_Missense_Mutation_p.M598T	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1063					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ATGATCAAAATGGAAGTGAAC	0.632			NA											10	26					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9061942	9061942	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:9061942G>C	uc002mkp.2	-	3	25708	c.25504C>G	c.(25504-25506)CCT>GCT	p.P8502A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8504	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAGCCCCAGGAGAACCTGTC	0.488			NA											25	122					0	0	0.008361	0	0
MUC16	94025	broad.mit.edu	37	19	9069683	9069683	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:9069683C>T	uc002mkp.2	-	3	17967	c.17763G>A	c.(17761-17763)GTG>GTA	p.V5921V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5923	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTTCTTCCACAGAGGGAG	0.498			NA											12	23					0	0	0.013537	0	0
ELOF1	84337	broad.mit.edu	37	19	11665067	11665067	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:11665067C>T	uc002mse.1	-	2	160	c.96G>A	c.(94-96)GAG>GAA	p.E32E	ELOF1_uc002msd.1_Silent_p.E53E	NM_032377	NP_115753	P60002	ELOF1_HUMAN	elongation factor 1 homolog (ELF1, S.	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding				0						CACAGGATTTCTCGTGGTTGC	0.577			NA											20	66					0	0	0.003954	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13930173	13930173	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:13930173G>T	uc002mxh.1	+	9	1765	c.1576G>T	c.(1576-1578)GGT>TGT	p.G526C	ZSWIM4_uc010xng.1_Missense_Mutation_p.G449C	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	526							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TCCTGCAGGGGGTCCCTTCAG	0.637			NA											3	13					0.00024832	0.000270754	0.009096	1	0
AKAP8	10270	broad.mit.edu	37	19	15483984	15483984	+	Missense_Mutation	SNP	C	C	T	rs144996992		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:15483984C>T	uc002nav.2	-	5	600	c.539G>A	c.(538-540)CGG>CAG	p.R180Q	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_5'UTR	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	180					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						AAGGGAGCCCCGCTCCCGGGC	0.682	GBM(190;1671 2163 3274 27186 30476)		NA											3	25					0	0	0.009096	0	0
FAM129C	199786	broad.mit.edu	37	19	17644449	17644449	+	Silent	SNP	G	G	T	rs140293166	by1000genomes	TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:17644449G>T	uc010xpr.1	+	5	597	c.459G>T	c.(457-459)ACG>ACT	p.T153T	FAM129C_uc010xpq.1_Silent_p.T153T|FAM129C_uc010xps.1_Silent_p.T122T|FAM129C_uc010xpt.1_RNA	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	153											0						CAGGATACACGCTCCTGACTT	0.517			NA											12	33					0.000422831	0.000456762	0.004007	1	0
FAM129C	199786	broad.mit.edu	37	19	17650003	17650003	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:17650003G>T	uc010xpr.1	+	7	871	c.733G>T	c.(733-735)GCC>TCC	p.A245S	FAM129C_uc010xpq.1_Missense_Mutation_p.A245S|FAM129C_uc002ngy.3_5'UTR|FAM129C_uc010xpu.1_5'UTR|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_5'UTR|FAM129C_uc002nhb.2_5'Flank	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	245											0						CTTCCTGGACGCCGTCCGACT	0.697			NA											5	6					3.59834e-05	3.99815e-05	0.001168	1	0
NCAN	1463	broad.mit.edu	37	19	19349097	19349097	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:19349097C>A	uc002nlz.2	+	11	3385	c.3286C>A	c.(3286-3288)CAG>AAG	p.Q1096K	NCAN_uc010ecc.1_Missense_Mutation_p.Q660K|NCAN_uc002nma.2_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1096	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCATAAGTTCCAGGGCCACTG	0.657			NA											29	45					5.52252e-06	6.29603e-06	0.010818	1	0
TYROBP	7305	broad.mit.edu	37	19	36398370	36398370	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:36398370A>T	uc002ocm.2	-	3	263	c.207T>A	c.(205-207)CCT>CCA	p.P69P	TYROBP_uc002ocn.2_Silent_p.P69P	NM_003332	NP_003323	O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	69	Cytoplasmic (Potential).				axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity				0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCGCCCCCGAGGGACCAGCC	0.662			NA											25	86					0	0	0.007291	0	0
PRX	57716	broad.mit.edu	37	19	40902612	40902612	+	Silent	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:40902612C>G	uc002onr.2	-	7	1916	c.1647G>C	c.(1645-1647)CCG>CCC	p.P549P	PRX_uc002onq.2_Silent_p.P410P|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	549	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|18.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.P549P(1)		ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGACACTTTCGGCAGCTGTA	0.577			NA											4	124					0	0	0.000602	0	0
PRX	57716	broad.mit.edu	37	19	40902620	40902620	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:40902620G>C	uc002onr.2	-	7	1908	c.1639C>G	c.(1639-1641)CAG>GAG	p.Q547E	PRX_uc002onq.2_Missense_Mutation_p.Q408E|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	547	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|18.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTCGGCAGCTGTACCTCTGGA	0.587			NA											4	124					0	0	0.000602	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224083	42224083	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:42224083C>T	uc002ork.2	+	7	1848	c.1727C>T	c.(1726-1728)TCA>TTA	p.S576L	CEACAM5_uc002orj.1_Missense_Mutation_p.S575L|CEACAM5_uc002orl.2_Missense_Mutation_p.S576L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	576	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		ATCCAGAACTCAGTGAGTGCA	0.517			NA											11	140					0	0	0.003163	0	0
PSG8	440533	broad.mit.edu	37	19	43262416	43262417	+	Missense_Mutation	DNP	GG	GG	AA	rs140447066	by1000genomes	TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:43262416_43262417GG>AA	uc002ouo.2	-	3	544_545	c.446_447CC>TT	c.(445-447)CCC>CTT	p.P149L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_5'UTR|PSG8_uc002ouh.2_Missense_Mutation_p.P149L|PSG8_uc010ein.2_Missense_Mutation_p.P27L|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_5'UTR|PSG8_uc002oul.3_Missense_Mutation_p.P149L|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	149	Ig-like C2-type 1.					extracellular region					0		Prostate(69;0.00899)				TGGAGATGGAGGGCTTGGGAGT	0.52			NA											50	69					0	0	0.004672	0	0
ZNF229	7772	broad.mit.edu	37	19	44934284	44934284	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:44934284C>G	uc002oze.1	-	6	1106	c.672G>C	c.(670-672)TGG>TGC	p.W224C	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Missense_Mutation_p.W218C	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GACAAGATATCCAGCAAAAGC	0.388			NA											35	24					0	0	0.00874	0	0
FUT1	2523	broad.mit.edu	37	19	49253877	49253877	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:49253877C>A	uc002pkk.2	-	4	1637	c.662G>T	c.(661-663)CGT>CTT	p.R221L		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	221	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		ATAGTCCCCACGGCGCACGTG	0.687			NA											26	41					1.06801e-11	1.31159e-11	0.009535	1	0
SIGLEC11	114132	broad.mit.edu	37	19	50463829	50463829	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr19:50463829G>A	uc010ybh.1	-	2	531	c.440C>T	c.(439-441)GCG>GTG	p.A147V	SIGLEC11_uc010ybi.1_Missense_Mutation_p.A147V	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	147	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TAGAAAGAACGCATTGCTCAG	0.562			NA											8	38					0	0	0.004482	0	0
GEN1	348654	broad.mit.edu	37	2	17962335	17962335	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:17962335C>T	uc002rct.2	+	14	1929	c.1856C>T	c.(1855-1857)TCA>TTA	p.S619L	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.S619L|GEN1_uc002rcu.2_Missense_Mutation_p.S619L	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	619					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCAGAGCTATCAGCCATCCCT	0.373			NA						Homologous_recombination					9	26					0	0	0.010729	0	0
NCOA1	8648	broad.mit.edu	37	2	24929670	24929670	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:24929670C>G	uc002rfk.2	+	11	1589	c.1331C>G	c.(1330-1332)TCA>TGA	p.S444*	NCOA1_uc010eye.2_Nonsense_Mutation_p.S444*|NCOA1_uc002rfi.2_Nonsense_Mutation_p.S293*|NCOA1_uc002rfj.2_Nonsense_Mutation_p.S444*|NCOA1_uc002rfl.2_Nonsense_Mutation_p.S444*	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	444	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCGGATGCTCACCCGGAAGT	0.458			NA	T	PAX3	alveolar rhadomyosarcoma								12	99					0	0	0.003163	0	0
CAD	790	broad.mit.edu	37	2	27457389	27457389	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:27457389G>A	uc002rji.2	+	23	3784	c.3622G>A	c.(3622-3624)GAC>AAC	p.D1208N	CAD_uc010eyw.2_Missense_Mutation_p.D1145N	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1208	CPSase B.|ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCCCCAGGATGACCAGCTGAA	0.393			NA											4	159					0	0	0.001984	0	0
FOSL2	2355	broad.mit.edu	37	2	28635264	28635264	+	Silent	SNP	C	C	T	rs141121352		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:28635264C>T	uc002rma.2	+	4	1739	c.930C>T	c.(928-930)AGC>AGT	p.S310S	FOSL2_uc010ymi.1_Silent_p.S271S	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	310					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCAGTAGCAGCGGGGACCAAT	0.622			NA											3	75					0	0	0.009096	0	0
GPR75	10936	broad.mit.edu	37	2	54081891	54081891	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:54081891C>T	uc002rxo.3	-	2	274	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	1	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTGTTGAGTTCATTTTCGGAG	0.522			NA											19	107					0	0	0.012319	0	0
CIAO1	9391	broad.mit.edu	37	2	96934240	96934240	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:96934240G>A	uc002svs.2	+	5	740	c.535G>A	c.(535-537)GAG>AAG	p.E179K	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	179	WD 4.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						GCTGTACCGGGAGGAAGAGGA	0.562			NA											5	89					0	0	0.00308	0	0
IL1F8	27177	broad.mit.edu	37	2	113788652	113788652	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:113788652C>A	uc002tiq.1	-	3	198	c.94G>T	c.(94-96)GCT>TCT	p.A32S	IL1F8_uc002tir.1_Missense_Mutation_p.A32S	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	32					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CTAAGAGGAGCTGCTATTAAA	0.493			NA											15	39					6.49762e-13	8.18046e-13	0.006122	1	0
WDR33	55339	broad.mit.edu	37	2	128479467	128479467	+	Silent	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:128479467T>C	uc002tpg.1	-	15	1797	c.1614A>G	c.(1612-1614)CAA>CAG	p.Q538Q		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	538					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CAATTTCTGCTTGTGTTTTTT	0.393			NA											23	42					0	0	0.014323	0	0
TTN	7273	broad.mit.edu	37	2	179422610	179422610	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:179422610G>C	uc010zfg.1	-	277	79991	c.79767C>G	c.(79765-79767)CTC>CTG	p.L26589L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L20284L|TTN_uc010zfi.1_Silent_p.L20217L|TTN_uc010zfj.1_Silent_p.L20092L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27516							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCCCATTTGAGAGTCACAC	0.428			NA											12	128					0	0	0.013537	0	0
CCDC141	285025	broad.mit.edu	37	2	179736233	179736233	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:179736233G>A	uc002unf.1	-	4	458	c.401C>T	c.(400-402)TCT>TTT	p.S134F		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	134							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GTCAAGTGCAGACACAGGCAT	0.403			NA											6	77					0	0	0.001168	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803549	185803549	+	Silent	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:185803549A>T	uc002uph.2	+	4	4020	c.3426A>T	c.(3424-3426)TCA>TCT	p.S1142S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1142						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CCAGAACCTCATTACCTCAGC	0.423			NA											22	42					0	0	0.014323	0	0
MARS2	92935	broad.mit.edu	37	2	198570892	198570892	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:198570892G>T	uc002uuq.2	+	1	806	c.763G>T	c.(763-765)GTG>TTG	p.V255L	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	255					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	CGACCTGTCCGTGTCTCGCAG	0.602			NA											28	50					3.33393e-15	4.27427e-15	0.004878	1	0
FZD7	8324	broad.mit.edu	37	2	202900672	202900672	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:202900672C>T	uc002uyw.1	+	1	1363	c.1302C>T	c.(1300-1302)TTC>TTT	p.F434F		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	434	Helical; Name=5; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						TCTACCTCTTCATAGGCACGT	0.612			NA									OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	40					0	0	0.000602	0	0
TMEM169	92691	broad.mit.edu	37	2	216965204	216965204	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:216965204A>G	uc010zjr.1	+	4	1159	c.833A>G	c.(832-834)AAT>AGT	p.N278S	TMEM169_uc010zjs.1_Missense_Mutation_p.N278S|TMEM169_uc002vfw.2_Missense_Mutation_p.N278S|TMEM169_uc002vfv.3_Missense_Mutation_p.N278S	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	278	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAATCCGACAATATCTCAAGC	0.542			NA											12	36					0	0	0.00245	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217281011	217281011	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:217281011G>A	uc002vgc.3	+	4	1173	c.843G>A	c.(841-843)ATG>ATA	p.M281I	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.M281I|SMARCAL1_uc010fvg.2_Missense_Mutation_p.M281I	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	281	HARP 1.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		ACTTCAGCATGAATGACTATA	0.438			NA							Schimke_Immuno-Osseous_Dysplasia				8	95					0	0	0.008291	0	0
D2HGDH	728294	broad.mit.edu	37	2	242690756	242690756	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr2:242690756G>A	uc002wce.1	+	8	1266	c.1093G>A	c.(1093-1095)GGC>AGC	p.G365S	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.G231S|D2HGDH_uc002wcg.1_Intron|D2HGDH_uc002wch.2_Intron|D2HGDH_uc002wci.2_Missense_Mutation_p.G64S	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	365					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCTGGGCTCCGGCCTGGTGAC	0.622			NA											3	33					0	0	0.000602	0	0
FASTKD5	60493	broad.mit.edu	37	20	3127632	3127632	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:3127632C>T	uc002whz.2	-	2	2396	c.2085G>A	c.(2083-2085)ATG>ATA	p.M695I	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	695					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						CAGCCAGCTTCATTCTTGGGG	0.557			NA											6	73					0	0	0.00308	0	0
ATRN	8455	broad.mit.edu	37	20	3571954	3571954	+	Splice_Site	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:3571954G>T	uc002wim.2	+	19	3412	c.3322_splice	c.e19+1	p.P1108_splice	ATRN_uc002wil.2_Splice_Site_p.P1108_splice	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1						inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						AAATGTCAGCGTAAGTCAAAT	0.463			NA											15	85					1.33834e-09	1.59326e-09	0.007413	1	0
HSPA12B	116835	broad.mit.edu	37	20	3730746	3730746	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:3730746C>T	uc002wjd.2	+	11	1276	c.1173C>T	c.(1171-1173)TTC>TTT	p.F391F	HSPA12B_uc010zqi.1_Silent_p.F390F|HSPA12B_uc002wje.2_Silent_p.F304F|HSPA12B_uc010zqj.1_Silent_p.F225F	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	391							ATP binding				0						CCATCGCCTTCGAGGCTCGCA	0.627			NA											3	12					0	0	0.001168	0	0
CRLS1	54675	broad.mit.edu	37	20	5990502	5990502	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:5990502G>C	uc002wmn.3	+	2	542	c.388G>C	c.(388-390)GAA>CAA	p.E130Q	CRLS1_uc010gbq.2_RNA|CRLS1_uc010gbr.2_Missense_Mutation_p.E31Q|CRLS1_uc010gbs.1_Missense_Mutation_p.E19Q	NM_019095	NP_061968	Q9UJA2	CRLS1_HUMAN	cardiolipin synthase 1 isoform 1	130					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphotransferase activity, for other substituted phosphate groups				0						TTTGATTATTGAAGAAGATTT	0.393			NA											2	29					0	0	0.004672	0	0
C20orf103	24141	broad.mit.edu	37	20	9496746	9496746	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:9496746C>A	uc002wni.1	+	3	566	c.337C>A	c.(337-339)CGC>AGC	p.R113S	C20orf103_uc010zrc.1_Intron	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	113	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			CTGGGTGGATCGCGCATATGC	0.622			NA											7	17					3.09899e-07	3.59154e-07	0.004482	1	0
PAK7	57144	broad.mit.edu	37	20	9546591	9546591	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:9546591C>T	uc002wnl.2	-	6	1976	c.1431G>A	c.(1429-1431)GTG>GTA	p.V477V	PAK7_uc002wnk.2_Silent_p.V477V|PAK7_uc002wnj.2_Silent_p.V477V|PAK7_uc010gby.1_Silent_p.V477V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	477	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CCATTTTCTTCACTGCAACTT	0.458			NA											11	117					0	0	0.001855	0	0
XRN2	22803	broad.mit.edu	37	20	21327175	21327175	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:21327175G>A	uc002wsf.1	+	17	1747	c.1652G>A	c.(1651-1653)AGA>AAA	p.R551K	XRN2_uc002wsg.1_Missense_Mutation_p.R475K|XRN2_uc010zsk.1_Missense_Mutation_p.R497K	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	551					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						TGGGTTCTTAGATATTATTAC	0.303			NA											15	60					0	0	0.007413	0	0
SDC4	6385	broad.mit.edu	37	20	43959123	43959123	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:43959123C>T	uc002xnu.2	-	4	368	c.328G>A	c.(328-330)GAG>AAG	p.E110K	SDC4_uc010zws.1_Missense_Mutation_p.E38K	NM_002999	NP_002990	P31431	SDC4_HUMAN	syndecan 4 precursor	110	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity				0		Myeloproliferative disorder(115;0.0122)				GGGATAACCTCATTCTCCTCT	0.532			NA											12	25					0	0	0.001855	0	0
SLC12A5	57468	broad.mit.edu	37	20	44671916	44671916	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr20:44671916C>A	uc010zxl.1	+	9	1336	c.1260C>A	c.(1258-1260)ACC>ACA	p.T420T	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Silent_p.T397T	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	420	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTGATATGACCTCCTACTTCA	0.567			NA											105	206					1.15969e-64	1.57322e-64	0.01441	1	0
CXADR	1525	broad.mit.edu	37	21	18919367	18919367	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:18919367C>T	uc002yki.2	+	2	184	c.66C>T	c.(64-66)ATC>ATT	p.I22I	CXADR_uc002ykh.1_Silent_p.I22I|CXADR_uc010gld.1_Silent_p.I22I|CXADR_uc010gle.1_Silent_p.I22I|CXADR_uc002ykj.1_5'UTR	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	22	Extracellular (Potential).|Ig-like C2-type 1.				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		GTTTGAGTATCACTACTCCTG	0.478			NA											6	74					0	0	0.001984	0	0
DSCR6	53820	broad.mit.edu	37	21	38380471	38380471	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:38380471G>A	uc002yvv.2	+	2	329	c.119G>A	c.(118-120)CGA>CAA	p.R40Q	DSCR6_uc011aec.1_5'UTR|DSCR6_uc010gnd.2_5'UTR	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Down syndrome critical region protein 6	40	WRPW motif.					nucleus				breast(1)	1		Myeloproliferative disorder(46;0.0632)				GCGCCGTGGCGACCTTGGATC	0.577	Colon(134;194 1731 2725 51652 51982)		NA											5	41					0	0	0.001168	0	0
UMODL1	89766	broad.mit.edu	37	21	43529807	43529807	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:43529807A>T	uc002zaf.1	+	10	1655	c.1655A>T	c.(1654-1656)GAG>GTG	p.E552V	UMODL1_uc002zad.1_Missense_Mutation_p.E480V|UMODL1_uc002zae.1_Missense_Mutation_p.E480V|UMODL1_uc002zag.1_Missense_Mutation_p.E552V|C21orf128_uc002zak.2_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	552	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CGGGCCTGTGAGGGTACGTGT	0.617	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											15	23					0	0	0.007413	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											7	29					0	0	0.001984	0	0
CRYAA	1409	broad.mit.edu	37	21	44589361	44589361	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:44589361C>T	uc002zdd.1	+	1	221	c.152C>T	c.(151-153)TCC>TTC	p.S51F		NM_000394	NP_000385	P02489	CRYAA_HUMAN	crystallin, alpha A	51					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding			breast(1)|central_nervous_system(1)	2						TACCGCCAGTCCCTCTTCCGC	0.632			NA											9	177					0	0	0.001855	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr21:47754527A>G	uc002zji.3	+	3	591	c.484A>G	c.(484-486)AGT>GGT	p.S162G	PCNT_uc002zjj.2_Missense_Mutation_p.S44G|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552			NA											3	95					0	0	0.000602	0	0
GNAZ	2781	broad.mit.edu	37	22	23438057	23438057	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr22:23438057G>T	uc002zwu.1	+	2	712	c.175G>T	c.(175-177)GGC>TGC	p.G59C	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	59						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		CATCCACAGCGGCGGCTTCAA	0.602			NA											15	124					7.07596e-05	7.81257e-05	0.006122	1	0
AP1B1	162	broad.mit.edu	37	22	29726395	29726395	+	Missense_Mutation	SNP	C	C	T	rs142354304	byFrequency	TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr22:29726395C>T	uc003afj.2	-	21	2922	c.2738G>A	c.(2737-2739)CGG>CAG	p.R913Q	AP1B1_uc003afi.2_Missense_Mutation_p.R906Q|AP1B1_uc003afk.2_Missense_Mutation_p.R906Q|AP1B1_uc003afl.2_Missense_Mutation_p.R886Q|AP1B1_uc003afh.2_Missense_Mutation_p.R110Q|AP1B1_uc011ako.1_Missense_Mutation_p.R466Q	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	913					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CGGCTGGATCCGCAGCTCCGC	0.667			NA											5	36					0	0	0.001168	0	0
SLC5A4	6527	broad.mit.edu	37	22	32647853	32647853	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr22:32647853G>T	uc003ami.2	-	3	218	c.216C>A	c.(214-216)GCC>GCA	p.A72A		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	72	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAAAGAGAGAGGCGCCCATCT	0.438			NA											27	21					1.06801e-11	1.31159e-11	0.009535	1	0
LARGE	9215	broad.mit.edu	37	22	33960945	33960945	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr22:33960945C>A	uc003and.3	-	7	1255	c.676G>T	c.(676-678)GTC>TTC	p.V226F	LARGE_uc011amd.1_Missense_Mutation_p.V25F|LARGE_uc003ane.3_Missense_Mutation_p.V226F|LARGE_uc010gwp.2_Missense_Mutation_p.V226F|LARGE_uc011ame.1_Missense_Mutation_p.V158F|LARGE_uc011amf.1_Missense_Mutation_p.V226F|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	226	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				TTGGTCAGGACAAGCTTCATC	0.483	Colon(70;397 1175 4573 19089 45288)		NA											22	42					1.87028e-06	2.14623e-06	0.012319	1	0
C3orf20	84077	broad.mit.edu	37	3	14768449	14768449	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:14768449G>C	uc003byy.2	+	11	2012	c.1608G>C	c.(1606-1608)AAG>AAC	p.K536N	C3orf20_uc003byz.2_Missense_Mutation_p.K414N|C3orf20_uc003bza.2_Missense_Mutation_p.K414N|C3orf20_uc003bzb.1_Missense_Mutation_p.K37N	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	536						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AGGTGTATAAGATGAGCCGAG	0.537			NA											5	45					0	0	0.000602	0	0
TRIM71	131405	broad.mit.edu	37	3	32932777	32932777	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:32932777G>A	uc003cff.2	+	4	2144	c.2081G>A	c.(2080-2082)GGA>GAA	p.G694E		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	694	NHL 3.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						GGTGAGAAAGGAACCAAGAAT	0.537			NA											4	20					0	0	0.000602	0	0
SCN5A	6331	broad.mit.edu	37	3	38595897	38595897	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:38595897C>T	uc003cio.2	-	27	4880	c.4686G>A	c.(4684-4686)AAG>AAA	p.K1562K	SCN5A_uc003cin.2_Silent_p.K1561K|SCN5A_uc003cil.3_Silent_p.K1562K|SCN5A_uc010hhi.2_Silent_p.K1544K|SCN5A_uc010hhk.2_Silent_p.K1561K|SCN5A_uc011ayr.1_Silent_p.K1508K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1562	Helical; Name=S2 of repeat IV; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCAGGTTGATCTTGGCCAAGA	0.478			NA											9	86					0	0	0.010729	0	0
LZTFL1	54585	broad.mit.edu	37	3	45868857	45868857	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:45868857C>G	uc003cox.1	-	9	1010	c.872G>C	c.(871-873)AGA>ACA	p.R291T	LZTFL1_uc003coy.1_Missense_Mutation_p.R274T|LZTFL1_uc011bak.1_Intron	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	291	Potential.										0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CTGTGCCAGTCTTTTCCTCAG	0.403			NA											5	45					0	0	0.000602	0	0
MAP4	4134	broad.mit.edu	37	3	47958144	47958144	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:47958144A>G	uc003csb.2	-	7	1699	c.1173T>C	c.(1171-1173)GCT>GCC	p.A391A	MAP4_uc003csc.3_Silent_p.A391A|MAP4_uc011bbf.1_Silent_p.A368A|MAP4_uc003csf.3_Silent_p.A408A	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	391	17 X 14 AA tandem repeats.|26 residues 2.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTTGGAAGGAGCCAAGTCCA	0.443			NA											3	85					0	0	0.004672	0	0
MAP4	4134	broad.mit.edu	37	3	47958147	47958147	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:47958147C>T	uc003csb.2	-	7	1696	c.1170G>A	c.(1168-1170)TTG>TTA	p.L390L	MAP4_uc003csc.3_Silent_p.L390L|MAP4_uc011bbf.1_Silent_p.L367L|MAP4_uc003csf.3_Silent_p.L407L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	390	17 X 14 AA tandem repeats.|26 residues 2.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGAAGGAGCCAAGTCCATTT	0.448			NA											3	86					0	0	0.004672	0	0
GPX1	2876	broad.mit.edu	37	3	49395018	49395018	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:49395018C>T	uc011bcl.1	-	3	495	c.415G>A	c.(415-417)GAC>AAC	p.D139N	GPX1_uc011bcm.1_3'UTR	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	139					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	GCGGTGGCGTCGTCGCTGGGA	0.632			NA											11	22					0	0	0.003163	0	0
NPRL2	10641	broad.mit.edu	37	3	50385968	50385968	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:50385968G>C	uc003daj.1	-	7	1113	c.710C>G	c.(709-711)TCC>TGC	p.S237C	ZMYND10_uc003dag.1_5'Flank|ZMYND10_uc010hll.1_5'Flank|ZMYND10_uc003dah.1_5'Flank|ZMYND10_uc010hlm.1_5'Flank|NPRL2_uc003dai.1_Missense_Mutation_p.S117C|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	237					negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						CTGGAGGATGGACACCAGTGT	0.582			NA											6	59					0	0	0.004482	0	0
PCNP	57092	broad.mit.edu	37	3	101311480	101311480	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:101311480A>G	uc003dva.2	+	5	438	c.420A>G	c.(418-420)CCA>CCG	p.P140P	PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_Missense_Mutation_p.N122D	NM_020357	NP_065090	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear	140					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0						GGGATACACCAACATCAGCTG	0.338			NA											13	29					0	0	0.00499	0	0
CCDC54	84692	broad.mit.edu	37	3	107096474	107096474	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:107096474A>T	uc003dwi.1	+	1	287	c.40A>T	c.(40-42)AGG>TGG	p.R14W		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	14											0						AGCTGCTGCTAGGCAGATGTG	0.408			NA											14	54					0	0	0.004007	0	0
PLXND1	23129	broad.mit.edu	37	3	129290552	129290552	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:129290552G>C	uc003emx.2	-	16	3313	c.3213C>G	c.(3211-3213)ATC>ATG	p.I1071M		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1071	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGATGGCCGTGATGACCGGGT	0.667	Ovarian(97;366 1484 3738 22084 39045)		NA											4	84					0	0	0.00308	0	0
PLXND1	23129	broad.mit.edu	37	3	129291746	129291746	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:129291746G>C	uc003emx.2	-	14	2976	c.2876C>G	c.(2875-2877)TCA>TGA	p.S959*		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	959	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CACCACACCTGAGAGTGGTCC	0.682	Ovarian(97;366 1484 3738 22084 39045)		NA											4	32					0	0	0.001168	0	0
TF	7018	broad.mit.edu	37	3	133467266	133467266	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:133467266G>T	uc003epu.1	+	7	1782	c.54G>T	c.(52-54)CTG>CTT	p.L18L	TF_uc011bls.1_Silent_p.L18L|TF_uc011blt.1_Intron|TF_uc003epw.1_Silent_p.L18L|TF_uc010htv.1_RNA|TF_uc003epv.1_Silent_p.L18L	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	18					cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GGCTGTGTCTGGCTGTCCCTG	0.572			NA											16	22					5.03518e-11	6.09797e-11	0.007413	1	0
TXNDC6	347736	broad.mit.edu	37	3	138023810	138023810	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:138023810G>T	uc003esg.2	-	9	724	c.696C>A	c.(694-696)CTC>CTA	p.L232L	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Silent_p.L147L|TXNDC6_uc003ese.1_Silent_p.L171L	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	232	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						CAGTCCTGGTGAGGATCAGGA	0.597			NA											12	141					4.36969e-10	5.23764e-10	0.001855	1	0
XRN1	54464	broad.mit.edu	37	3	142083991	142083991	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:142083991C>T	uc003eus.2	-	29	3359	c.3292G>A	c.(3292-3294)GAT>AAT	p.D1098N	XRN1_uc010huu.2_Missense_Mutation_p.D564N|XRN1_uc003eut.2_Missense_Mutation_p.D1098N|XRN1_uc003euu.2_Missense_Mutation_p.D1098N	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1098					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						GCATCCCGATCAGGAATGACT	0.343			NA											4	34					0	0	0.000602	0	0
B3GALNT1	8706	broad.mit.edu	37	3	160804158	160804158	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:160804158A>G	uc003fdv.2	-	5	804	c.385T>C	c.(385-387)TTG>CTG	p.L129L	B3GALNT1_uc003fdw.2_Silent_p.L129L|B3GALNT1_uc003fdx.2_Silent_p.L129L|B3GALNT1_uc003fdy.2_Silent_p.L129L|B3GALNT1_uc003fdz.2_Silent_p.L129L|B3GALNT1_uc003fea.2_Silent_p.L129L|B3GALNT1_uc011bpa.1_Intron	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	129	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			GACAATGCCAACATTTTGTCT	0.383			NA											6	56					0	0	0.001984	0	0
MYNN	55892	broad.mit.edu	37	3	169501310	169501310	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:169501310C>T	uc003fft.2	+	6	1874	c.1445C>T	c.(1444-1446)TCC>TTC	p.S482F	MYNN_uc011bpm.1_Missense_Mutation_p.S368F|MYNN_uc003ffu.2_Missense_Mutation_p.S482F|MYNN_uc003ffv.2_Missense_Mutation_p.S209F|MYNN_uc010hwo.2_Missense_Mutation_p.S482F|MYNN_uc003ffw.1_RNA	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	482	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AGTTTTATTTCCTCAGGAGAG	0.328			NA											22	68					0	0	0.00632	0	0
PSMD2	5708	broad.mit.edu	37	3	184024551	184024551	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:184024551C>T	uc003fnn.1	+	16	1996	c.1963C>T	c.(1963-1965)CTG>TTG	p.L655L	PSMD2_uc011brj.1_Silent_p.L496L|PSMD2_uc011brk.1_Silent_p.L525L	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	655					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	AGTGGCTGTTCTGGGGATTGC	0.443	Colon(24;313 636 6917 9932 15554)		NA											36	82					0	0	0.009718	0	0
CHRD	8646	broad.mit.edu	37	3	184100663	184100663	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:184100663G>C	uc003fov.2	+	9	1248	c.1002G>C	c.(1000-1002)TTG>TTC	p.L334F	CHRD_uc003fow.2_Intron|CHRD_uc003fox.2_Missense_Mutation_p.L334F|CHRD_uc003foy.2_Intron|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'UTR	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	334	CHRD 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGTTCCCTTGAGGCTCCAGA	0.577			NA											4	10					0	0	0.009096	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186793407	186793407	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr3:186793407C>G	uc003frb.2	+	8	1469	c.1037C>G	c.(1036-1038)TCC>TGC	p.S346C	ST6GAL1_uc003frc.2_Missense_Mutation_p.S115C|ST6GAL1_uc003frd.2_Missense_Mutation_p.S346C	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	346	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		TTCCTCCCATCCAAGCGCAAG	0.522			NA											13	41					0	0	0.003163	0	0
ZNF718	255403	broad.mit.edu	37	4	154780	154780	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:154780G>T	uc003fzt.3	+	8	438	c.305G>T	c.(304-306)GGA>GTA	p.G102V	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		ATACCAAAAGGACATGAGAAA	0.338			NA											5	20					2.0095e-06	2.29844e-06	0.001984	1	0
LGI2	55203	broad.mit.edu	37	4	25005381	25005381	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:25005381G>A	uc003grf.2	-	8	1429	c.1330C>T	c.(1330-1332)CGG>TGG	p.R444W		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	444	EAR 5.					extracellular region					0		Breast(46;0.173)				CTCATGACCCGGGAGTCCCCG	0.522			NA											27	231					0	0	0.007291	0	0
GABRG1	2565	broad.mit.edu	37	4	46067491	46067491	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:46067491C>G	uc003gxb.2	-	4	584	c.432G>C	c.(430-432)TGG>TGC	p.W144C		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	144	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGTCAGGAATCCAAATTTTTC	0.358			NA											10	17					0	0	0.006214	0	0
CORIN	10699	broad.mit.edu	37	4	47765548	47765548	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:47765548C>A	uc003gxm.2	-	4	558	c.465G>T	c.(463-465)ACG>ACT	p.T155T	CORIN_uc011bzf.1_Silent_p.T16T|CORIN_uc011bzg.1_Silent_p.T88T|CORIN_uc011bzh.1_Silent_p.T155T|CORIN_uc011bzi.1_Silent_p.T155T|CORIN_uc003gxn.3_Silent_p.T155T	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	155	Extracellular (Potential).|FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						GAGGTGTCAGCGTGGCGTGGT	0.468			NA											19	89					1.96895e-08	2.29711e-08	0.00278	1	0
PDGFRA	5156	broad.mit.edu	37	4	55161414	55161414	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:55161414A>G	uc003han.3	+	23	3576	c.3245A>G	c.(3244-3246)GAC>GGC	p.D1082G	PDGFRA_uc003haa.2_Missense_Mutation_p.D842G	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1082	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GACTCTTCAGACCTGGTGGAA	0.512	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			12	95					0	0	0.00245	0	0
EPHA5	2044	broad.mit.edu	37	4	66509083	66509083	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:66509083C>G	uc003hcy.2	-	2	437	c.244G>C	c.(244-246)GGG>CGG	p.G82R	EPHA5_uc003hcx.2_Missense_Mutation_p.G13R|EPHA5_uc003hcz.2_Missense_Mutation_p.G82R|EPHA5_uc011cah.1_Missense_Mutation_p.G82R|EPHA5_uc011cai.1_Missense_Mutation_p.G82R|EPHA5_uc003hda.2_Missense_Mutation_p.G82R	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	82	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAACTTACCCCATTTTTTGGA	0.343			NA								TSP Lung(17;0.13)			6	20					0	0	0.004482	0	0
SEC24D	9871	broad.mit.edu	37	4	119665242	119665242	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:119665242C>T	uc003ici.3	-	15	2168	c.1896G>A	c.(1894-1896)GTG>GTA	p.V632V	SEC24D_uc003ich.3_RNA|SEC24D_uc003icj.3_Silent_p.V633V|SEC24D_uc003icl.2_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	632					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						GGAAGAGTGTCACAGAGCAGC	0.473			NA											3	50					0	0	0.009096	0	0
NEK1	4750	broad.mit.edu	37	4	170477147	170477147	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr4:170477147G>A	uc003isb.1	-	16	1858	c.1366C>T	c.(1366-1368)CAA>TAA	p.Q456*	NEK1_uc003isc.1_Nonsense_Mutation_p.Q456*|NEK1_uc003isd.1_Nonsense_Mutation_p.Q456*|NEK1_uc003ise.1_Nonsense_Mutation_p.Q456*|NEK1_uc003isf.1_Nonsense_Mutation_p.Q431*|NEK1_uc003isg.1_Nonsense_Mutation_p.Q377*	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	456					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCTGCTCTTTGTTGCTGCATT	0.418			NA											3	13					0	0	0.004672	0	0
IRX2	153572	broad.mit.edu	37	5	2747711	2747711	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:2747711G>A	uc003jda.2	-	4	1625	c.1383C>T	c.(1381-1383)ACC>ACT	p.T461T	IRX2_uc003jdb.2_Silent_p.T461T	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	461						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		CGCCAACCACGGTGCAGCCCT	0.652			NA											3	91					0	0	0.004672	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239860	5239860	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:5239860C>G	uc003jdl.2	+	16	2483	c.2345C>G	c.(2344-2346)TCT>TGT	p.S782C	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S782C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	782	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATGAACGTCTCTACCTCCTAC	0.493			NA											6	103					0	0	0.004482	0	0
FASTKD3	79072	broad.mit.edu	37	5	7863072	7863072	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:7863072A>T	uc003jeb.2	-	4	1700	c.1563T>A	c.(1561-1563)TTT>TTA	p.F521L	FASTKD3_uc011cmp.1_Missense_Mutation_p.F223L|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	521					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						ATGGGGTAAGAAATGACTTCA	0.353			NA											12	196					0	0	0.004007	0	0
DNAH5	1767	broad.mit.edu	37	5	13809157	13809157	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:13809157C>A	uc003jfd.2	-	46	7790	c.7748G>T	c.(7747-7749)GGC>GTC	p.G2583V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2583	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATACCTTGCCCTGTTTAGC	0.338			NA							Kartagener_syndrome				11	85					0.000978159	0.00104059	0.010729	1	0
PRDM9	56979	broad.mit.edu	37	5	23527693	23527693	+	Silent	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:23527693T>C	uc003jgo.2	+	11	2678	c.2496T>C	c.(2494-2496)TAT>TAC	p.Y832Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	832	C2H2-type 13.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAAGCCCTATGTCTGCAGGG	0.587			NA								HNSCC(3;0.000094)			7	178					0	0	0.004482	0	0
CDH9	1007	broad.mit.edu	37	5	26906068	26906068	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:26906068T>A	uc003jgs.1	-	5	980	c.811A>T	c.(811-813)AGT>TGT	p.S271C	CDH9_uc010iug.2_Missense_Mutation_p.S271C	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	271	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CATTTCTTACTCTGGGGAAAT	0.433	Melanoma(8;187 585 15745 40864 52829)		NA											42	144					0	0	0.01441	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41004595	41004595	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:41004595G>T	uc003jmj.3	-	37	4537	c.4047C>A	c.(4045-4047)ATC>ATA	p.I1349I	HEATR7B2_uc003jmi.3_Silent_p.I904I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1349							binding			ovary(6)|central_nervous_system(2)	8						GGCCTCTGATGATAGATTCTA	0.423			NA											21	13					2.27731e-05	2.55467e-05	0.012319	1	0
C6	729	broad.mit.edu	37	5	41176734	41176734	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:41176734G>C	uc003jmk.2	-	8	1221	c.1011C>G	c.(1009-1011)GTC>GTG	p.V337V	C6_uc003jml.1_Silent_p.V337V	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	337	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTTTCAAAAAGACATCAGAAA	0.383			NA											6	66					0	0	0.00308	0	0
MEF2C	4208	broad.mit.edu	37	5	88018598	88018598	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:88018598C>A	uc003kjj.2	-	11	1918	c.1245G>T	c.(1243-1245)GAG>GAT	p.E415D	MEF2C_uc003kji.2_Missense_Mutation_p.E407D|MEF2C_uc003kjk.2_Missense_Mutation_p.E415D|MEF2C_uc003kjm.2_Missense_Mutation_p.E405D|MEF2C_uc003kjl.2_Missense_Mutation_p.E425D	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	415					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATCTCCCCGCCTCGTGGCGCG	0.562			NA								HNSCC(66;0.2)			14	40					3.45872e-05	3.85526e-05	0.004007	1	0
POLR3G	10622	broad.mit.edu	37	5	89781433	89781433	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:89781433G>A	uc003kjq.2	+	2	249	c.49G>A	c.(49-51)GAG>AAG	p.E17K	POLR3G_uc011cuc.1_Missense_Mutation_p.E17K	NM_006467	NP_006458	O15318	RPC7_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	17					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)		CTTTAATATTGAGGCTGTTGG	0.398			NA											3	60					0	0	0.009096	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216127	140216127	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:140216127C>T	uc003lhq.2	+	1	2159	c.2159C>T	c.(2158-2160)GCG>GTG	p.A720V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A720V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	720	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTACACGGCGTTGCGGTGC	0.617	NSCLC(160;258 2013 5070 22440 28951)		NA											28	45					0	0	0.009535	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256768	140256768	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:140256768G>A	uc003lic.2	+	1	1838	c.1711G>A	c.(1711-1713)GGC>AGC	p.G571S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.G571S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	571	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTCCGGCTGGCAGCGCAGG	0.697	Pancreas(113;759 1672 13322 24104 50104)		NA											19	76					0	0	0.00333	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754648	140754648	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:140754648T>A	uc003ljy.1	+	1	998	c.998T>A	c.(997-999)GTC>GAC	p.V333D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.V333D	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	333	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGCGAAAGTCTTAATAACT	0.433			NA											48	103					0	0	0.01441	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140812657	140812657	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:140812657C>G	uc003lkt.1	+	1	2500	c.2331C>G	c.(2329-2331)GAC>GAG	p.D777E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.D777E	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	777	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTATGCAGACATGCTCGTCA	0.522			NA											11	127					0	0	0.013537	0	0
PDGFRB	5159	broad.mit.edu	37	5	149513572	149513572	+	Splice_Site	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:149513572C>A	uc003lro.2	-	5	1101	c.632_splice	c.e5-1	p.V211_splice	PDGFRB_uc010jhd.2_Splice_Site_p.V50_splice|PDGFRB_uc011dcg.1_Splice_Site_p.V211_splice	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta						aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ATGGATGACACTGGTAGAGAG	0.542			NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								13	74					3.45872e-05	3.85526e-05	0.004007	1	0
FAM71B	153745	broad.mit.edu	37	5	156589685	156589685	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:156589685C>A	uc003lwn.2	-	2	1691	c.1591G>T	c.(1591-1593)GCC>TCC	p.A531S		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	531						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATCTTACTGGCTTTCTTTTGT	0.473			NA											3	21					0.004672	0.00485223	0.004672	1	0
ITK	3702	broad.mit.edu	37	5	156670710	156670710	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:156670710G>T	uc003lwo.1	+	12	1220	c.1138G>T	c.(1138-1140)GGC>TGC	p.G380C		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	380	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGCATCTGGGCTACTGGCT	0.498	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								17	68					1.22574e-08	1.43481e-08	0.014323	1	0
CYFIP2	26999	broad.mit.edu	37	5	156712415	156712415	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:156712415A>C	uc003lwq.2	+	2	182	c.44A>C	c.(43-45)GAC>GCC	p.D15A	CYFIP2_uc011ddn.1_Missense_Mutation_p.D15A|CYFIP2_uc011ddo.1_Missense_Mutation_p.D15A|CYFIP2_uc003lwr.2_Missense_Mutation_p.D15A|CYFIP2_uc003lws.2_Missense_Mutation_p.D15A|CYFIP2_uc003lwp.2_5'UTR	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	15					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCAACGTGGACCTGCTTGAA	0.542			NA											4	10					0	0	0.001168	0	0
UNC5A	90249	broad.mit.edu	37	5	176300975	176300975	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr5:176300975C>G	uc003mey.2	+	7	1085	c.893C>G	c.(892-894)TCT>TGT	p.S298C	UNC5A_uc010jkg.1_Missense_Mutation_p.S258C	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	298	Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGCTGCTTCTGGCCCTGAG	0.627			NA											8	46					0	0	0.010729	0	0
DSP	1832	broad.mit.edu	37	6	7568679	7568679	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:7568679G>A	uc003mxp.1	+	11	1555	c.1276G>A	c.(1276-1278)GAG>AAG	p.E426K	DSP_uc003mxq.1_Missense_Mutation_p.E426K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	426	Globular 1.|Spectrin 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAAGAACGAGAGAAAATCCT	0.383			NA											3	46					0	0	0.004672	0	0
SYCP2L	221711	broad.mit.edu	37	6	10902949	10902949	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:10902949G>A	uc003mzo.2	+	7	802	c.506G>A	c.(505-507)GGA>GAA	p.G169E	SYCP2L_uc011din.1_Missense_Mutation_p.G10E|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	169						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			CTTAGCTTAGGATTCCTGGTG	0.358			NA											11	19					0	0	0.013537	0	0
JARID2	3720	broad.mit.edu	37	6	15511564	15511564	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:15511564G>A	uc003nbj.2	+	13	3128	c.2884G>A	c.(2884-2886)GAT>AAT	p.D962N	JARID2_uc011div.1_Missense_Mutation_p.D790N	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	962	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CAAGCTGGAAGATGTGGTCCA	0.567			NA											12	95					0	0	0.006122	0	0
TRIM31	11074	broad.mit.edu	37	6	30078327	30078327	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:30078327C>T	uc003npg.1	-	4	752	c.642G>A	c.(640-642)GGG>GGA	p.G214G	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	214						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						CATAGTGTTTCCCCGCTTCCG	0.512			NA											10	112					0	0	0.001855	0	0
EHMT2	10919	broad.mit.edu	37	6	31855433	31855433	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:31855433C>T	uc003nxz.1	-	15	1942	c.1932G>A	c.(1930-1932)CGG>CGA	p.R644R	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.R435R|EHMT2_uc011don.1_Silent_p.R667R|EHMT2_uc003nya.1_Silent_p.R610R	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	644					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGAGCTTCTTCCGCCTGCCAA	0.592			NA											5	80					0	0	0.001168	0	0
TDRD6	221400	broad.mit.edu	37	6	46659781	46659781	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:46659781A>T	uc003oyj.2	+	1	3916	c.3916A>T	c.(3916-3918)AAA>TAA	p.K1306*	TDRD6_uc010jze.2_Nonsense_Mutation_p.K1300*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1306					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GCCTGGATTTAAAACAACTGT	0.323			NA											8	10					0	0	0.006214	0	0
GPR115	221393	broad.mit.edu	37	6	47675035	47675035	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:47675035C>A	uc003oza.1	+	2	312	c.54C>A	c.(52-54)TCC>TCA	p.S18S	GPR115_uc003oyz.1_Intron|GPR115_uc003ozb.1_Silent_p.S16S	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	18					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						TCTTTCTGTCCACAGAATGTT	0.423	GBM(22;431 510 9010 26644 32828)		NA											13	47					4.35082e-09	5.16199e-09	0.010504	1	0
COL9A1	1297	broad.mit.edu	37	6	70993463	70993463	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:70993463G>T	uc003pfg.3	-	6	916	c.757C>A	c.(757-759)CAT>AAT	p.H253N	COL9A1_uc003pff.3_5'Flank	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	253	Nonhelical region (NC4).	Zinc.			axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGCAGCTCATGGCAAGTTTCT	0.522			NA											5	15					0.00198382	0.00209137	0.001984	1	0
SH3BGRL2	83699	broad.mit.edu	37	6	80383466	80383466	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:80383466C>A	uc003piz.1	+	2	360	c.181C>A	c.(181-183)CAG>AAG	p.Q61K		NM_031469	NP_113657	Q9UJC5	SH3L2_HUMAN	SH3 domain binding glutamic acid-rich protein	61	SH3-binding (Potential).					nucleus	SH3 domain binding				0		all_cancers(76;0.00188)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.174)		BRCA - Breast invasive adenocarcinoma(397;0.0278)		GAAACCCACTCAGGGCAACCC	0.458			NA											7	68					0.00307968	0.00321758	0.00308	1	0
GPRC6A	222545	broad.mit.edu	37	6	117113821	117113821	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:117113821C>G	uc003pxj.1	-	6	2287	c.2265G>C	c.(2263-2265)ATG>ATC	p.M755I	GPRC6A_uc003pxk.1_Missense_Mutation_p.M580I|GPRC6A_uc003pxl.1_Missense_Mutation_p.M684I	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	755	Helical; Name=5; (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGTAGCCCAGCATGGTGCCAA	0.448			NA											9	20					0	0	0.013537	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151130291	151130291	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:151130291C>T	uc003qny.1	+	9	1275	c.963C>T	c.(961-963)TAC>TAT	p.Y321Y	PLEKHG1_uc011eel.1_Silent_p.Y361Y|PLEKHG1_uc011eem.1_Silent_p.Y380Y|PLEKHG1_uc003qnz.2_Silent_p.Y321Y	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	321	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TGACCAGCTACGGGGAACTGG	0.557			NA											9	49					0	0	0.006214	0	0
SNX9	51429	broad.mit.edu	37	6	158358492	158358492	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:158358492G>A	uc003qqv.1	+	15	1643	c.1470G>A	c.(1468-1470)ATG>ATA	p.M490I		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	490	BAR.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		ATTTCCTGATGGAATGTAATC	0.383			NA											9	99					0	0	0.010729	0	0
CCR6	1235	broad.mit.edu	37	6	167549755	167549755	+	Missense_Mutation	SNP	G	G	T	rs145768514		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:167549755G>T	uc003qvl.2	+	13	2513	c.37G>T	c.(37-39)GAC>TAC	p.D13Y	CCR6_uc010kkm.2_Missense_Mutation_p.D13Y|CCR6_uc003qvn.3_Missense_Mutation_p.D13Y|CCR6_uc003qvm.3_Missense_Mutation_p.D13Y	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	13	Extracellular (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CGATGTTTTCGACTCCAGTGA	0.413			NA											39	49					9.84934e-19	1.30086e-18	0.010771	1	0
THBS2	7058	broad.mit.edu	37	6	169620303	169620303	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr6:169620303G>A	uc003qwt.2	-	22	3749	c.3501C>T	c.(3499-3501)TAC>TAT	p.Y1167Y		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	1167	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CTCTGCATTCGTACTTGAGGT	0.512	Esophageal Squamous(91;219 1934 18562 44706)		NA											59	58					0	0	0.01441	0	0
AGR3	155465	broad.mit.edu	37	7	16900125	16900125	+	Silent	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:16900125T>A	uc003sts.2	-	7	523	c.450A>T	c.(448-450)CTA>CTT	p.L150L		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	150						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		AATACTTACATAGGGGTAAAT	0.423			NA											17	51					0	0	0.012319	0	0
AHR	196	broad.mit.edu	37	7	17369593	17369593	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:17369593G>C	uc011jxz.1	+	5	1081	c.468G>C	c.(466-468)CAG>CAC	p.Q156H	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	156	PAS 1.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TCATACATCAGAGTGTATATG	0.348			NA											4	13					0	0	0.009096	0	0
TBX20	57057	broad.mit.edu	37	7	35289601	35289601	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:35289601A>T	uc011kas.1	-	2	353	c.342T>A	c.(340-342)CAT>CAA	p.H114Q		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	114	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						TGCCCAGCTCATGGAATTTGT	0.582			NA											16	63					0	0	0.010504	0	0
KIAA0895	23366	broad.mit.edu	37	7	36396957	36396957	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:36396957G>A	uc003tfd.2	-	3	472	c.421C>T	c.(421-423)CCT>TCT	p.P141S	KIAA0895_uc003tfc.2_Missense_Mutation_p.P128S|KIAA0895_uc011kaw.1_5'UTR|KIAA0895_uc003tfb.2_Missense_Mutation_p.P90S|KIAA0895_uc011kax.1_Missense_Mutation_p.P90S|KIAA0895_uc003tfe.2_Missense_Mutation_p.P128S|KIAA0895_uc011kay.1_Missense_Mutation_p.P90S	NM_001100425	NP_001093895	Q8NCT3	K0895_HUMAN	hypothetical protein LOC23366 isoform 1	141											0						GAAGTGTTAGGAGATTTGCTG	0.463			NA											13	14					0	0	0.00245	0	0
VWC2	375567	broad.mit.edu	37	7	49815691	49815692	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:49815691_49815692CC>AA	uc003tot.1	+	2	1216_1217	c.660_661CC>AA	c.(658-663)TTCCGG>TTAAGG	p.F220L		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	220	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						ACTGCGAGTTCCGGGGCAAGAC	0.629			NA											3	7					0	0	0.004672	0	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:57187809T>G	uc010kzo.2	-	5	1584	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453			NA											4	64					0	0	0.000602	0	0
RFC2	5982	broad.mit.edu	37	7	73663380	73663380	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:73663380G>C	uc003uaj.2	-	4	319	c.294C>G	c.(292-294)CTC>CTG	p.L98L	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Silent_p.L98L|RFC2_uc010lbp.2_Silent_p.L61L|RFC2_uc003ual.2_5'UTR	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	98					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2						TGGCATCTTTGAGTGCTGGGC	0.527			NA											3	70					0	0	0.004672	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027106	92027106	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:92027106T>A	uc003ulw.2	+	19	2841	c.2465T>A	c.(2464-2466)GTG>GAG	p.V822E	ANKIB1_uc010lew.1_Missense_Mutation_p.V91E	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	822							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCTATGAGTGTGCTGCACAGC	0.527			NA											3	149					0	0	0.004672	0	0
MUC17	140453	broad.mit.edu	37	7	100682585	100682585	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:100682585G>A	uc003uxp.1	+	3	7941	c.7888G>A	c.(7888-7890)GAA>AAA	p.E2630K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2630	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGTAAGTAC	0.458			NA											24	196					0	0	0.00632	0	0
MUC17	140453	broad.mit.edu	37	7	100684763	100684763	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:100684763G>A	uc003uxp.1	+	3	10119	c.10066G>A	c.(10066-10068)GAG>AAG	p.E3356K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3356	Extracellular (Potential).|54.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGTCAGTTCTGAGGCTAGCAC	0.483			NA											13	315					0	0	0.00245	0	0
HYAL4	23553	broad.mit.edu	37	7	123516999	123516999	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:123516999C>T	uc003vlc.2	+	5	1874	c.1236C>T	c.(1234-1236)GAC>GAT	p.D412D	HYAL4_uc011knz.1_3'UTR	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	412	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						CCTCTGAGGACGGGGAGTTTA	0.478			NA											5	46					0	0	0.000602	0	0
GRM8	2918	broad.mit.edu	37	7	126410032	126410032	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:126410032G>A	uc003vlr.2	-	6	1555	c.1244C>T	c.(1243-1245)GCC>GTC	p.A415V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.A415V|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.A136V	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	415	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ATTGTGCAGGGCGTAAGCCAT	0.438			NA								HNSCC(24;0.065)			6	40					0	0	0.001168	0	0
AKR1B10	57016	broad.mit.edu	37	7	134216764	134216764	+	Silent	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:134216764A>G	uc003vrr.2	+	3	659	c.339A>G	c.(337-339)CCA>CCG	p.P113P		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	113					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						TTCACTGGCCACAGGGATTCA	0.507			NA											5	78					0	0	0.001168	0	0
DGKI	9162	broad.mit.edu	37	7	137172408	137172408	+	Missense_Mutation	SNP	C	C	A	rs148779791		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:137172408C>A	uc003vtt.2	-	23	2331	c.2330G>T	c.(2329-2331)CGT>CTT	p.R777L	DGKI_uc003vtu.2_Missense_Mutation_p.R477L	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	777					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ACAGTCTCCACGCACAACTAG	0.368			NA											39	109					1.83081e-24	2.45511e-24	0.01441	1	0
EPHA1	2041	broad.mit.edu	37	7	143096797	143096797	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:143096797C>A	uc003wcz.2	-	4	869	c.782G>T	c.(781-783)CGG>CTG	p.R261L		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	261	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ACAGTGGCACCGTCCTACAGG	0.657			NA											16	52					3.57192e-18	4.6999e-18	0.006122	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175698	143175698	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:143175698C>G	uc003wdc.1	+	1	733	c.733C>G	c.(733-735)CTG>GTG	p.L245V	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	245	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TCTTTATGCTCTGTCCTTTCT	0.502			NA											6	57					0	0	0.00308	0	0
ZNF862	643641	broad.mit.edu	37	7	149557595	149557595	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:149557595A>G	uc010lpn.2	+	7	1538	c.1346A>G	c.(1345-1347)GAA>GGA	p.E449G	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						ATTTGTGAGGAAGGAGATGGA	0.567			NA											26	59					0	0	0.007291	0	0
KCNH2	3757	broad.mit.edu	37	7	150643967	150643967	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:150643967G>C	uc003wic.2	-	14	3341	c.3328C>G	c.(3328-3330)CAG>GAG	p.Q1110E	KCNH2_uc003wib.2_Missense_Mutation_p.Q770E|KCNH2_uc011kux.1_Missense_Mutation_p.Q1014E	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	1110	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GAGCTTACCTGAGAAAGCGAG	0.642	GBM(137;110 1844 13671 20123 45161)		NA											7	64					0	0	0.00308	0	0
RP1L1	94137	broad.mit.edu	37	8	10470721	10470721	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:10470721G>A	uc003wtc.2	-	4	1116	c.887C>T	c.(886-888)ACG>ATG	p.T296M		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	296					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTGAGCTGGCGTGTCCTGAGG	0.657			NA											14	45					0	0	0.00245	0	0
HOOK3	84376	broad.mit.edu	37	8	42841831	42841831	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:42841831G>A	uc003xpr.2	+	15	1667	c.1425G>A	c.(1423-1425)AAG>AAA	p.K475K	HOOK3_uc010lxq.1_Silent_p.K475K	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	475	Potential.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			ATGAGAATAAGATGTTAAAGC	0.343			NA	T	RET	papillary thyroid								4	34					0	0	0.000602	0	0
SNAI2	6591	broad.mit.edu	37	8	49832849	49832849	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:49832849G>A	uc003xqp.2	-	2	395	c.231C>T	c.(229-231)TCC>TCT	p.S77S		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	77					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				AGGAGTATCCGGAAAGAGGAG	0.567			NA											6	66					0	0	0.001168	0	0
PXDNL	137902	broad.mit.edu	37	8	52320897	52320897	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:52320897C>A	uc003xqu.3	-	17	3388	c.3287G>T	c.(3286-3288)GGG>GTG	p.G1096V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1096					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CGGGTCTATCCCACCTTCCTT	0.547			NA											11	30					1.41608e-15	1.82216e-15	0.001855	1	0
CLVS1	157807	broad.mit.edu	37	8	62371093	62371093	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:62371093G>T	uc003xuh.2	+	5	1293	c.969G>T	c.(967-969)CTG>CTT	p.L323L	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Intron	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	323					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CACCCAAGCTGATGAAAAGGT	0.433			NA											5	8					1.26484e-09	1.51091e-09	0.00308	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885555	88885555	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:88885555C>A	uc003ydz.2	-	1	742	c.645G>T	c.(643-645)ACG>ACT	p.T215T		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	215										ovary(1)	1						GCTGGTGTCCCGTCACCACGT	0.542			NA											24	130					2.48779e-11	3.0339e-11	0.005443	1	0
RBM12B	389677	broad.mit.edu	37	8	94746552	94746552	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:94746552T>G	uc003yfz.2	-	3	2280	c.2087A>C	c.(2086-2088)GAG>GCG	p.E696A		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	696							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GAAGTCATCCTCGGGTGGTCG	0.627			NA											47	141					0	0	0.01441	0	0
TMEM67	91147	broad.mit.edu	37	8	94807657	94807657	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:94807657G>T	uc011lgk.1	+	17	1766	c.1695G>T	c.(1693-1695)GTG>GTT	p.V565V	TMEM67_uc010maw.2_Silent_p.V271V|TMEM67_uc003yga.3_Silent_p.V484V|TMEM67_uc011lgl.1_5'UTR	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	565					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AATTCTTGGTGTACTATGCTG	0.343			NA											27	67					2.09667e-21	2.79024e-21	0.003755	1	0
MTERFD1	51001	broad.mit.edu	37	8	97270789	97270789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:97270789G>A	uc003yhs.1	-	2	208	c.130C>T	c.(130-132)CAG>TAG	p.Q44*	MTERFD1_uc003yhr.1_5'Flank|MTERFD1_uc010mbd.1_Nonsense_Mutation_p.Q44*	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	44					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					ATCTGAGGCTGAGCAGAAAAG	0.423			NA											8	93					0	0	0.004482	0	0
KLHL38	340359	broad.mit.edu	37	8	124663831	124663831	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:124663831C>A	uc003yqs.1	-	1	1360	c.1336G>T	c.(1336-1338)GTG>TTG	p.V446L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	446	Kelch 4.										0						ATAAGGCGCACAGGGTTCTGC	0.537			NA											36	59					3.4345e-17	4.46868e-17	0.011902	1	0
NDUFB9	4715	broad.mit.edu	37	8	125562071	125562071	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:125562071G>A	uc003yrg.3	+	4	563	c.478G>A	c.(478-480)GAA>AAA	p.E160K	NDUFB9_uc011lim.1_Intron	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	160					mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	TGCCCGAAAGGAAGGTGATTT	0.522			NA											7	47					0	0	0.004482	0	0
MTSS1	9788	broad.mit.edu	37	8	125565305	125565305	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:125565305C>T	uc003yrk.2	-	14	2730	c.2196G>A	c.(2194-2196)CTG>CTA	p.L732L	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Silent_p.L381L|MTSS1_uc011lin.1_Silent_p.L506L|MTSS1_uc011lio.1_Silent_p.L622L|MTSS1_uc003yri.2_Silent_p.L450L|MTSS1_uc003yrj.2_Silent_p.L707L|MTSS1_uc003yrl.2_Silent_p.L736L	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	732	WH2.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGATGGCGTTCAGCATGTCTT	0.562	Esophageal Squamous(160;622 1893 3862 8546 12509)		NA											11	149					0	0	0.001855	0	0
MTSS1	9788	broad.mit.edu	37	8	125565318	125565318	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:125565318C>T	uc003yrk.2	-	14	2717	c.2183G>A	c.(2182-2184)GGA>GAA	p.G728E	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.G377E|MTSS1_uc011lin.1_Missense_Mutation_p.G502E|MTSS1_uc011lio.1_Missense_Mutation_p.G618E|MTSS1_uc003yri.2_Missense_Mutation_p.G446E|MTSS1_uc003yrj.2_Missense_Mutation_p.G703E|MTSS1_uc003yrl.2_Missense_Mutation_p.G732E	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	728	WH2.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CATGTCTTCTCCTTGTGGAGT	0.557	Esophageal Squamous(160;622 1893 3862 8546 12509)		NA											11	168					0	0	0.013537	0	0
ASAP1	50807	broad.mit.edu	37	8	131072883	131072883	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:131072883T>C	uc003yta.1	-	27	3162	c.3134A>G	c.(3133-3135)AAC>AGC	p.N1045S	ASAP1_uc003ysz.1_Missense_Mutation_p.N856S|ASAP1_uc011liw.1_Missense_Mutation_p.N1038S	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	1045					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CGTGAGGTCGTTGGAGTCTTC	0.537			NA											42	73					0	0	0.011902	0	0
ASAP1	50807	broad.mit.edu	37	8	131130783	131130783	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:131130783G>C	uc003yta.1	-	18	1774	c.1746C>G	c.(1744-1746)GTC>GTG	p.V582V	ASAP1_uc003ysz.1_Silent_p.V393V|ASAP1_uc011liw.1_Silent_p.V575V	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	582					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CTTCTGCATAGACTTGAATTA	0.398			NA											34	37					0	0	0.009718	0	0
CYP11B1	1584	broad.mit.edu	37	8	143960993	143960993	+	Silent	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr8:143960993G>A	uc003yxi.2	-	1	244	c.237C>T	c.(235-237)TTC>TTT	p.F79F	CYP11B1_uc003yxj.2_Silent_p.F79F|CYP11B1_uc010mey.2_Silent_p.F79F	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	79					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGCTTTACCTGAAAATGGGCC	0.627			NA							Familial_Hyperaldosteronism_type_I				3	69					0	0	0.004672	0	0
JAK2	3717	broad.mit.edu	37	9	5044417	5044417	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:5044417G>T	uc010mhm.2	+	4	478	c.365G>T	c.(364-366)CGT>CTT	p.R122L	JAK2_uc003ziw.2_Missense_Mutation_p.R122L	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	122	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TACTTTCCTCGTTGGTATTGC	0.393			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				15	40					4.14922e-12	5.14974e-12	0.004007	1	0
PTPRD	5789	broad.mit.edu	37	9	8341727	8341727	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:8341727C>G	uc003zkk.2	-	39	5624	c.4913G>C	c.(4912-4914)GGA>GCA	p.G1638A	PTPRD_uc003zkp.2_Missense_Mutation_p.G1232A|PTPRD_uc003zkq.2_Missense_Mutation_p.G1231A|PTPRD_uc003zkr.2_Missense_Mutation_p.G1222A|PTPRD_uc003zks.2_Missense_Mutation_p.G1231A|PTPRD_uc003zkl.2_Missense_Mutation_p.G1629A|PTPRD_uc003zkm.2_Missense_Mutation_p.G1625A|PTPRD_uc003zkn.2_Missense_Mutation_p.G1227A|PTPRD_uc003zko.2_Missense_Mutation_p.G1228A	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1638	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACATTCTCTCCCGTTTCTAT	0.433			NA								TSP Lung(15;0.13)			31	94					0	0	0.00623	0	0
MPDZ	8777	broad.mit.edu	37	9	13109986	13109986	+	Silent	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:13109986C>A	uc010mhy.2	-	43	5871	c.5820G>T	c.(5818-5820)GGG>GGT	p.G1940G	MPDZ_uc003zkx.3_Silent_p.G164G|MPDZ_uc003zky.3_Silent_p.G503G|MPDZ_uc010mib.2_Silent_p.G674G|MPDZ_uc010mhx.2_Silent_p.G791G|MPDZ_uc011lmm.1_Silent_p.G828G|MPDZ_uc003zkz.3_Silent_p.G662G|MPDZ_uc010mhz.2_Silent_p.G1936G|MPDZ_uc011lmn.1_Silent_p.G1907G|MPDZ_uc003zlb.3_Silent_p.G1940G	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1969					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TTGACGTCAGCCCAGTGAAAG	0.458			NA											5	13					0.000602214	0.000642607	0.000602	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777150	18777150	+	Silent	SNP	A	A	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:18777150A>C	uc003zne.3	+	19	3050	c.2923A>C	c.(2923-2925)AGA>CGA	p.R975R		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	975						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CTTGAGCCCGAGAAGTGAGGA	0.647			NA											5	40					0	0	0.000602	0	0
FAM154A	158297	broad.mit.edu	37	9	18929019	18929019	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:18929019C>T	uc003zni.1	-	4	734	c.456G>A	c.(454-456)GAG>GAA	p.E152E	FAM154A_uc010mip.1_5'UTR	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	152										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		GACGAAGTGGCTCTCGCCTTG	0.423			NA											7	42					0	0	0.006214	0	0
RRAGA	10670	broad.mit.edu	37	9	19050308	19050308	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:19050308C>T	uc003znj.2	+	1	937	c.651C>T	c.(649-651)TAC>TAT	p.Y217Y		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	217					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						TTTCCCACTACCAGTGCAAAG	0.478			NA											8	76					0	0	0.010729	0	0
AQP7	364	broad.mit.edu	37	9	33385097	33385097	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:33385097G>A	uc003zst.2	-	8	1107	c.935C>T	c.(934-936)TCT>TTT	p.S312F	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_3'UTR	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	312	Cytoplasmic (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		GGTGAGGGGAGAGATCGTGGG	0.557			NA											16	244					0	0	0.010504	0	0
NPR2	4882	broad.mit.edu	37	9	35799660	35799660	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:35799660C>T	uc003zyd.2	+	3	919	c.919C>T	c.(919-921)CAG>TAG	p.Q307*	NPR2_uc010mlb.2_Nonsense_Mutation_p.Q307*	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	307	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TCCTGAGTATCAGGAATTCCA	0.507			NA											13	61					0	0	0.004007	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608347	84608347	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:84608347C>A	uc004amn.2	+	4	3009	c.2962C>A	c.(2962-2964)CCT>ACT	p.P988T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	988						integral to membrane					0						TCGTCCTCACCCTGTCTCCTC	0.498			NA											34	100					2.42023e-17	3.16075e-17	0.003271	1	0
C9orf102	375748	broad.mit.edu	37	9	98685569	98685569	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:98685569C>G	uc004avt.3	+	9	1862	c.1474C>G	c.(1474-1476)CAG>GAG	p.Q492E	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.Q194E|C9orf102_uc010mry.1_Missense_Mutation_p.Q194E|C9orf102_uc010mrz.2_Missense_Mutation_p.Q303E|C9orf102_uc004avu.2_Translation_Start_Site	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	492					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				GATATGTGATCAGGTATTTTC	0.343			NA											4	57					0	0	0.001168	0	0
ASTN2	23245	broad.mit.edu	37	9	119738458	119738458	+	Silent	SNP	G	G	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:119738458G>T	uc004bjs.1	-	9	1787	c.1686C>A	c.(1684-1686)CCC>CCA	p.P562P	ASTN2_uc004bjr.1_Silent_p.P562P|ASTN2_uc004bjt.1_Silent_p.P511P	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	562	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GTGTCGTGTAGGGCCAAGGTC	0.493			NA											3	19					0.004672	0.00485223	0.004672	1	0
ASTN2	23245	broad.mit.edu	37	9	119770395	119770395	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:119770395C>T	uc004bjs.1	-	7	1668	c.1567G>A	c.(1567-1569)GAG>AAG	p.E523K	ASTN2_uc004bjr.1_Missense_Mutation_p.E523K|ASTN2_uc004bjt.1_Missense_Mutation_p.E472K	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	523	Extracellular (Potential).|EGF-like 1.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CAGAGCTGCTCACAGGCATCT	0.577			NA											4	54					0	0	0.001168	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377476	125377476	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:125377476C>A	uc011lyy.1	+	1	460	c.460C>A	c.(460-462)CTT>ATT	p.L154I		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTCTCCCACCTTCATGCCAT	0.478			NA											24	68					9.22233e-05	0.000101185	0.004656	1	0
SETX	23064	broad.mit.edu	37	9	135211746	135211746	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:135211746C>A	uc004cbk.2	-	6	838	c.655G>T	c.(655-657)GGT>TGT	p.G219C		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	219					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATCAGTTTACCCTTCTCTAGG	0.338			NA											10	26					9.31168e-06	1.05472e-05	0.001855	1	0
QSOX2	169714	broad.mit.edu	37	9	139107068	139107068	+	Missense_Mutation	SNP	G	G	C	rs145333884		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:139107068G>C	uc010nbi.2	-	10	1330	c.1292C>G	c.(1291-1293)TCT>TGT	p.S431C		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	431	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TTTCCAGAGAGAACACGGGTA	0.488			NA											4	27					0	0	0.009096	0	0
CACNA1B	774	broad.mit.edu	37	9	140811715	140811715	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr9:140811715C>G	uc004cog.2	+	6	943	c.798C>G	c.(796-798)TTC>TTG	p.F266L		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	266	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGGGTGACTTCCCCTGTGGCA	0.587			NA											9	33					0	0	0.004482	0	0
IL3RA	3563	broad.mit.edu	37	X	1471302	1471302	+	Silent	SNP	C	C	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:1471302C>G	uc004cps.2	+	6	868	c.519C>G	c.(517-519)CTC>CTG	p.L173L	IL3RA_uc011mhd.1_Silent_p.L95L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	173	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TCTCTCGACTCTCCAGCGGTT	0.542			NA											3	113					0	0	0.004672	0	0
CTPS2	56474	broad.mit.edu	37	X	16717203	16717203	+	Silent	SNP	G	G	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:16717203G>C	uc004cxk.2	-	3	924	c.180C>G	c.(178-180)GTC>GTG	p.V60V	CTPS2_uc004cxl.2_Silent_p.V60V|CTPS2_uc004cxm.2_Silent_p.V60V	NM_001144002	NP_001137474	Q9NRF8	PYRG2_HUMAN	cytidine triphosphate synthase II	60					glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)					CATCATTTAAGACGAAGACTT	0.313			NA											22	16					0	0	0.00278	0	0
RBM10	8241	broad.mit.edu	37	X	47039904	47039904	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:47039904A>T	uc004dhf.2	+	12	1626	c.1247A>T	c.(1246-1248)CAG>CTG	p.Q416L	RBM10_uc004dhg.2_Missense_Mutation_p.Q338L|RBM10_uc004dhh.2_Missense_Mutation_p.Q415L|RBM10_uc010nhq.2_Missense_Mutation_p.Q339L|RBM10_uc004dhi.2_Missense_Mutation_p.Q481L	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	416					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GCCATCTCACAGGTACTCAGA	0.602	Melanoma(171;120 2705 19495 39241)		NA											5	8					0	0	0.000602	0	0
ARAF	369	broad.mit.edu	37	X	47426121	47426122	+	Missense_Mutation	DNP	CC	CC	GT			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:47426121_47426122CC>GT	uc011mlq.1	+	7	774_775	c.641_642CC>GT	c.(640-642)TCC>TGT	p.S214C	ARAF_uc011mln.1_Intron|ARAF_uc011mlo.1_Missense_Mutation_p.S80C|ARAF_uc011mlp.1_Missense_Mutation_p.S214C|ARAF_uc004dic.1_5'UTR	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	214					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	CGCTCCACGTCCACTCCCAACG	0.663			NA											6	5					0	0	0.004672	0	0
USP51	158880	broad.mit.edu	37	X	55513511	55513511	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:55513511A>G	uc004dun.1	-	2	1941	c.1862T>C	c.(1861-1863)ATG>ACG	p.M621T	USP51_uc011moo.1_Missense_Mutation_p.M325T	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	621					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						AAACGGAGTCATGTCCAGCTC	0.443			NA											8	8					0	0	0.008291	0	0
ACRC	93953	broad.mit.edu	37	X	70823918	70823918	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:70823918C>T	uc004eae.2	+	8	1292	c.791C>T	c.(790-792)GCT>GTT	p.A264V	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	264	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GATTCGGAAGCTCCCGACGAC	0.557			NA											4	51					0	0	0.000602	0	0
KLHL4	56062	broad.mit.edu	37	X	86888884	86888884	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:86888884C>A	uc004efb.2	+	8	1867	c.1685C>A	c.(1684-1686)ACA>AAA	p.T562K	KLHL4_uc004efa.2_Missense_Mutation_p.T562K	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	562	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CCTAGAAGCACAGTTGGTGTT	0.433			NA											9	15					0.000442599	0.000476645	0.006214	1	0
CPXCR1	53336	broad.mit.edu	37	X	88008985	88008985	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:88008985C>A	uc004efd.3	+	3	829	c.570C>A	c.(568-570)CAC>CAA	p.H190Q	CPXCR1_uc004efc.3_Missense_Mutation_p.H190Q	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	190						intracellular	zinc ion binding			ovary(3)	3						TCACCCATCACGAGAGAGCCA	0.428			NA											12	4					4.7546e-09	5.622e-09	0.004007	1	0
GLUD2	2747	broad.mit.edu	37	X	120182249	120182249	+	Silent	SNP	T	T	C			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:120182249T>C	uc004eto.2	+	1	788	c.711T>C	c.(709-711)GCT>GCC	p.A237A		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	237					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCTGGATTGCTGATACCTATG	0.517			NA											26	23					0	0	0.003271	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996370	140996370	+	Silent	SNP	C	C	T			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:140996370C>T	uc004fbt.2	+	4	3466	c.3180C>T	c.(3178-3180)CCC>CCT	p.P1060P	MAGEC1_uc010nsl.1_Silent_p.P127P	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1060	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGGTGCCCAACTCTTCTC	0.512			NA								HNSCC(15;0.026)			4	51					0	0	0.000602	0	0
GABRQ	55879	broad.mit.edu	37	X	151821220	151821220	+	Missense_Mutation	SNP	C	C	A	rs77796656		TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chrX:151821220C>A	uc004ffp.1	+	9	1395	c.1375C>A	c.(1375-1377)CAG>AAG	p.Q459K		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	459						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CACCTCAGAGCAGGCCCGGCA	0.592			NA											12	46					2.61681e-11	3.18016e-11	0.00245	1	0
MTMR10	54893	broad.mit.edu	37	15	31253222	31253224	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	CCT	CCT	-	-	CCT	CCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr15:31253222_31253224delCCT	uc001zfh.1	-	7	716_718	c.618_620delAGG	c.(616-621)GGAGGT>GGT	p.206_207GG>G	MTMR10_uc010azx.1_5'UTR|MTMR10_uc001zfi.1_5'UTR|MTMR10_uc001zfj.2_In_Frame_Del_p.124_125GG>G|MTMR10_uc001zfk.2_5'UTR|MTMR10_uc010ubl.1_RNA	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	206_207	Poly-Gly.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		AGCTCCATTAcctcctcctcctc	0.369			NA											4	4	---	---	---	---	NA	NA	NA	NA	NA
CPLX3	594855	broad.mit.edu	37	15	75122558	75122560	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	GAG	GAG	-	-	GAG	GAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr15:75122558_75122560delGAG	uc002ayu.1	+	3	434_436	c.340_342delGAG	c.(340-342)GAGdel	p.E118del		NM_001030005	NP_001025176	Q8WVH0	CPLX3_HUMAN	complexin 3 precursor	118						cell junction|synapse	syntaxin binding				0						GGAGGACACAGAGGAGGAGGAGG	0.616			NA											7	85	---	---	---	---	NA	NA	NA	NA	NA
SLC26A11	284129	broad.mit.edu	37	17	78201649	78201651	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	TGC	TGC	-	-	TGC	TGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr17:78201649_78201651delTGC	uc002jyb.1	+	7	895_897	c.626_628delTGC	c.(625-630)ATGCTG>ATG	p.L213del	SLC26A11_uc002jyc.1_In_Frame_Del_p.L213del|SLC26A11_uc002jyd.1_In_Frame_Del_p.L213del|SLC26A11_uc010dhv.1_In_Frame_Del_p.L213del	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	213	Helical; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTGGTCTGCATGCTGCTGCTGCT	0.675			NA											8	197	---	---	---	---	NA	NA	NA	NA	NA
FAM38B	63895	broad.mit.edu	37	18	10681669	10681669	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr18:10681669delA	uc002kor.3	-	9	1440	c.1300delT	c.(1300-1302)TCTfs	p.S434fs	FAM38B_uc002koq.2_Frame_Shift_Del_p.S269fs	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2477						integral to membrane	ion channel activity			ovary(1)	1						GTGTCCCTAGAAAAAGCTTGT	0.398			NA											25	67	---	---	---	---	NA	NA	NA	NA	NA
ZAN	7455	broad.mit.edu	37	7	100373314	100373314	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7727-01A-11D-2167-08	TCGA-55-7727-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e4390b89-911b-447e-8b5a-8849274c1691	866211ea-f591-496a-a45b-51b1f3821bf0	g.chr7:100373314delC	uc003uwj.2	+	34	6216	c.6051delC	c.(6049-6051)CTCfs	p.L2017fs	ZAN_uc003uwk.2_Frame_Shift_Del_p.L2017fs|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Frame_Shift_Del_p.L104fs	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2017	Extracellular (Potential).|VWFD 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGGTCACCCTCCCCGCCATCT	0.567			NA											8	89	---	---	---	---	NA	NA	NA	NA	NA
