Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SSU72	29101	broad.mit.edu	37	1	1500240	1500240	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:1500240C>T	uc001agd.2	-	2	462	c.137G>A	c.(136-138)GGA>GAA	p.G46E	SSU72_uc009vkg.1_Missense_Mutation_p.G46E|SSU72_uc001age.1_Missense_Mutation_p.G46E	NM_014188	NP_054907	Q9NP77	SSU72_HUMAN	Ssu72 RNA polymerase II CTD phosphatase homolog	46					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity				0	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GGGAGCTGGTCCTGGAAGCTT	0.458			NA											26	94					0	0	0.003954	0	0
DNAJC11	55735	broad.mit.edu	37	1	6706000	6706000	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:6706000C>T	uc001aof.2	-	8	849	c.743G>A	c.(742-744)CGT>CAT	p.R248H	DNAJC11_uc010nzt.1_Missense_Mutation_p.R210H|DNAJC11_uc001aog.2_Missense_Mutation_p.R248H|DNAJC11_uc010nzu.1_Missense_Mutation_p.R158H	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	248					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCGGATTCCACGGGATGAAAA	0.537			NA											66	203					0	0	0.00361	0	0
CAMTA1	23261	broad.mit.edu	37	1	7805036	7805036	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:7805036A>G	uc001aoi.2	+	17	4531	c.4324A>G	c.(4324-4326)AGT>GGT	p.S1442G	CAMTA1_uc010nzv.1_Missense_Mutation_p.S529G|CAMTA1_uc001aok.3_Missense_Mutation_p.S485G|CAMTA1_uc001aoj.2_Missense_Mutation_p.S398G|CAMTA1_uc009vmf.2_Missense_Mutation_p.S46G	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTGGCTGGCCAGTTATCTAGC	0.517			NA											24	103					0	0	0.004656	0	0
C1orf200	644997	broad.mit.edu	37	1	9714056	9714056	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:9714056G>T	uc001aqc.3	-	2	435	c.285C>A	c.(283-285)CTC>CTA	p.L95L	PIK3CD_uc001aqa.2_Intron|PIK3CD_uc001aqb.3_Intron	NR_027045				RecName: Full=Putative uncharacterized protein C1orf200;												0	all_lung(157;0.222)	Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.86e-08)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(185;0.000231)|KIRC - Kidney renal clear cell carcinoma(229;0.000879)|BRCA - Breast invasive adenocarcinoma(304;0.00178)|STAD - Stomach adenocarcinoma(132;0.00331)|READ - Rectum adenocarcinoma(331;0.0419)		ttgaagccaggagttcaaggt	0.09			NA											6	28					5.9392e-07	6.705e-07	0.001168	1	0
CELA2B	51032	broad.mit.edu	37	1	15809791	15809791	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:15809791C>A	uc001awl.2	+	5	414	c.389C>A	c.(388-390)CCC>CAC	p.P130H		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	130	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CTGGCTAACCCCGTCTCCCTC	0.612			NA											29	94					2.81731e-10	3.54074e-10	0.002096	1	0
DDI2	84301	broad.mit.edu	37	1	15983175	15983175	+	Splice_Site	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:15983175G>T	uc001awx.1	+	9	1342	c.1246_splice	c.e9+1		DDI2_uc009voj.1_Splice_Site	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2						proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CCCAGACCAGGTATTTATAGA	0.468			NA											43	149					1.57019e-19	2.53548e-19	0.007835	1	0
MYOM3	127294	broad.mit.edu	37	1	24385442	24385442	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:24385442G>A	uc001bin.3	-	36	4185	c.4022C>T	c.(4021-4023)CCG>CTG	p.P1341L	MYOM3_uc001bil.3_Missense_Mutation_p.P234L|MYOM3_uc001bim.3_Missense_Mutation_p.P998L	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1341	Ig-like C2-type 4.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGCCACATCCGGCAGACCTCT	0.537			NA											4	14					0	0	0.000602	0	0
AHDC1	27245	broad.mit.edu	37	1	27876408	27876408	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:27876408C>G	uc009vsy.2	-	6	3188	c.2219G>C	c.(2218-2220)CGC>CCC	p.R740P	AHDC1_uc009vsz.1_Missense_Mutation_p.R740P	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	740	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCGTCTCTTGCGCTTTGGCTT	0.677			NA											18	69					0	0	0.008871	0	0
ADC	113451	broad.mit.edu	37	1	33562427	33562427	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:33562427C>T	uc001bwr.2	+	9	1460	c.873C>T	c.(871-873)ATC>ATT	p.I291I	ADC_uc001bws.2_Silent_p.I291I|ADC_uc009vue.2_Silent_p.I291I|ADC_uc001bwt.1_Silent_p.I196I|ADC_uc001bwu.2_Silent_p.I196I|ADC_uc001bwv.2_Silent_p.I196I|ADC_uc001bww.2_Silent_p.I196I|ADC_uc001bwx.1_Silent_p.I268I|ADC_uc001bwz.1_Silent_p.I291I|ADC_uc009vuf.1_Silent_p.I133I|ADC_uc001bwy.1_Silent_p.I140I|ADC_uc009vug.2_Silent_p.I291I	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	291					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CAGTCAGCATCATTGCCAAGA	0.592			NA											36	135					0	0	0.004289	0	0
EIF2C1	26523	broad.mit.edu	37	1	36381063	36381063	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:36381063C>T	uc001bzl.2	+	15	2161	c.1948C>T	c.(1948-1950)CAA>TAA	p.Q650*	EIF2C1_uc001bzk.2_Nonsense_Mutation_p.Q575*|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	650	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCTCCTCATCCAATTCTACAA	0.572			NA											39	85					0	0	0.004878	0	0
COL8A2	1296	broad.mit.edu	37	1	36563472	36563472	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:36563472C>A	uc001bzv.1	-	2	1817	c.1810G>T	c.(1810-1812)GGC>TGC	p.G604C	COL8A2_uc001bzw.1_Missense_Mutation_p.G539C	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	604	C1q.|Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGTTGTAGCCGCTGTGGCCA	0.622			NA											19	36					6.33239e-15	9.34442e-15	0.010504	1	0
RLF	6018	broad.mit.edu	37	1	40705942	40705942	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:40705942C>T	uc001cfc.3	+	8	5599	c.5568C>T	c.(5566-5568)TCC>TCT	p.S1856S	RLF_uc001cfd.3_Silent_p.S1547S	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1856					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CAGTTCCTTCCTTGGAAAACC	0.423			NA											38	116					0	0	0.005524	0	0
TIE1	7075	broad.mit.edu	37	1	43779579	43779579	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:43779579G>T	uc001ciu.2	+	14	2428	c.2349G>T	c.(2347-2349)CTG>CTT	p.L783L	TIE1_uc010oke.1_Silent_p.L738L|TIE1_uc009vwq.2_Silent_p.L739L|TIE1_uc010okf.1_Silent_p.L428L|TIE1_uc010okg.1_Silent_p.L428L	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	783	Helical; (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTTAACCCTGGTGTGCATCC	0.657			NA											17	52					3.62473e-10	4.51944e-10	0.001882	1	0
ATP6V0B	533	broad.mit.edu	37	1	44441771	44441771	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:44441771G>A	uc001cld.2	+	3	237	c.126G>A	c.(124-126)ACG>ACA	p.T42T	ATP6V0B_uc001clc.2_Silent_p.T42T|ATP6V0B_uc001cle.2_5'UTR|ATP6V0B_uc001clf.2_5'UTR	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	42	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				GGTTCCTGACGGAGACTTCGC	0.562			NA											15	208					0	0	0.007413	0	0
PIK3R3	8503	broad.mit.edu	37	1	46521524	46521524	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:46521524A>G	uc001cpb.3	-	7	1640	c.884T>C	c.(883-885)ATG>ACG	p.M295T	PIK3R3_uc009vyb.2_Intron|PIK3R3_uc009vyc.2_Missense_Mutation_p.M312T|PIK3R3_uc001cpc.3_Missense_Mutation_p.M295T|PIK3R3_uc010olw.1_Missense_Mutation_p.M341T|PIK3R3_uc010olv.1_Missense_Mutation_p.M85T	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	295					insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					GATGCTATTCATTTTTTTATC	0.428			NA											27	125					0	0	0.003755	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395930	47395930	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:47395930G>T	uc001cqp.3	-	12	1468	c.1417C>A	c.(1417-1419)CTG>ATG	p.L473M		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	473					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	AGCAGGGTCAGGGCCGTGGCC	0.542			NA											38	174					6.2361e-21	1.03672e-20	0.007835	1	0
DAB1	1600	broad.mit.edu	37	1	57611039	57611039	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:57611039G>T	uc001cys.1	-	5	805	c.131C>A	c.(130-132)GCC>GAC	p.A44D	DAB1_uc001cyt.1_Missense_Mutation_p.A44D|DAB1_uc001cyq.1_Missense_Mutation_p.A44D|DAB1_uc001cyr.1_Missense_Mutation_p.A44D|DAB1_uc009vzw.1_Missense_Mutation_p.A44D|DAB1_uc009vzx.1_Missense_Mutation_p.A44D	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	44	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						GATCAATTTGGCTTTGTACCG	0.418			NA											30	96					1.88708e-17	2.9622e-17	0.008361	1	0
DAB1	1600	broad.mit.edu	37	1	57611099	57611099	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:57611099T>A	uc001cys.1	-	5	745	c.71A>T	c.(70-72)CAG>CTG	p.Q24L	DAB1_uc001cyt.1_Missense_Mutation_p.Q24L|DAB1_uc001cyq.1_Missense_Mutation_p.Q24L|DAB1_uc001cyr.1_Missense_Mutation_p.Q24L|DAB1_uc009vzw.1_Missense_Mutation_p.Q24L|DAB1_uc009vzx.1_Missense_Mutation_p.Q24L	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	24					cell differentiation|nervous system development					skin(2)|ovary(1)	3						ACTGCGATCCTGACCTAAAAA	0.458			NA											20	71					0	0	0.010504	0	0
DOCK7	85440	broad.mit.edu	37	1	63084481	63084481	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:63084481C>G	uc001daq.2	-	14	1612	c.1578G>C	c.(1576-1578)CCG>CCC	p.P526P	DOCK7_uc001dan.2_Silent_p.P418P|DOCK7_uc001dao.2_Silent_p.P418P|DOCK7_uc001dap.2_Silent_p.P526P|DOCK7_uc009wah.1_Silent_p.P526P	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	526					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GAAGCAGCTCCGGAGTTAGGC	0.388			NA											69	242					0	0	0.00361	0	0
LEPR	3953	broad.mit.edu	37	1	66083707	66083707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:66083707G>A	uc001dci.2	+	16	2475	c.2273G>A	c.(2272-2274)TGG>TAG	p.W758*	LEPR_uc001dcg.2_Nonsense_Mutation_p.W758*|LEPR_uc001dch.2_Nonsense_Mutation_p.W758*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.W758*|LEPR_uc001dck.2_Nonsense_Mutation_p.W758*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	758	Extracellular (Potential).|Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATTGTTTCCTGGATACTATCA	0.313			NA											11	90					0	0	0.000978	0	0
SGIP1	84251	broad.mit.edu	37	1	67108500	67108500	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:67108500C>A	uc001dcr.2	+	6	453	c.236C>A	c.(235-237)CCT>CAT	p.P79H		NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	79					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TAGAACTCACCTGAGCTGGAT	0.328			NA											17	58					2.4624e-09	2.9944e-09	0.008871	1	0
TCTEX1D1	200132	broad.mit.edu	37	1	67243129	67243129	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:67243129C>A	uc001dcv.2	+	5	663	c.532C>A	c.(532-534)CTT>ATT	p.L178I	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	178											0						TGCAGTTTACCTTGAGTGATT	0.363			NA											30	111					3.73148e-12	5.12265e-12	0.007291	1	0
TNNI3K	51086	broad.mit.edu	37	1	74902192	74902192	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:74902192C>T	uc001dgf.1	+	19	1911	c.1860C>T	c.(1858-1860)AAC>AAT	p.N620N	TNNI3K_uc001dgd.2_Silent_p.N721N|TNNI3K_uc001dge.1_Silent_p.N721N	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	620	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ATGAAGACAACATGACAAAAC	0.358			NA											10	74					0	0	0.000978	0	0
SLC44A5	204962	broad.mit.edu	37	1	75672394	75672394	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:75672394C>A	uc001dgu.2	-	24	2202	c.2058G>T	c.(2056-2058)CTG>CTT	p.L686L	SLC44A5_uc001dgt.2_Intron|SLC44A5_uc001dgs.2_Intron|SLC44A5_uc001dgr.2_Intron|SLC44A5_uc010oqz.1_Intron|SLC44A5_uc010ora.1_Silent_p.L680L|SLC44A5_uc010orb.1_Silent_p.L556L	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	686	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CATTTCTTTCCAGATCTTCAC	0.413			NA											46	155					1.56793e-16	2.38059e-16	0.00361	1	0
LPHN2	23266	broad.mit.edu	37	1	82447508	82447508	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:82447508G>T	uc001dit.3	+	18	3260	c.3079G>T	c.(3079-3081)GCT>TCT	p.A1027S	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.A1027S|LPHN2_uc001div.2_Missense_Mutation_p.A1027S|LPHN2_uc009wcd.2_Missense_Mutation_p.A1027S|LPHN2_uc001diw.2_Missense_Mutation_p.A611S|LPHN2_uc009wce.1_Missense_Mutation_p.A128S	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1040	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGTGCTTGGCGCTTTCGCTCT	0.383			NA											110	365					7.036e-43	1.4072e-42	0.00361	1	0
C1orf52	148423	broad.mit.edu	37	1	85725280	85725280	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:85725280C>A	uc001dkv.2	-	1	76	c.37G>T	c.(37-39)GCG>TCG	p.A13S	C1orf52_uc001dkw.2_RNA|C1orf52_uc001dkx.3_RNA|C1orf52_uc009wcn.2_Missense_Mutation_p.A13S	NM_198077	NP_932343	Q8N6N3	CA052_HUMAN	hypothetical protein LOC148423	13										ovary(1)	1				all cancers(265;0.0105)|Epithelial(280;0.0293)		CCGTATGCCGCAAAATAGCTC	0.652			NA									OREG0013580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	16					8.12818e-05	8.70246e-05	0.001984	1	0
GBP1	2633	broad.mit.edu	37	1	89523826	89523826	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:89523826G>A	uc001dmx.2	-	6	943	c.723C>T	c.(721-723)CCC>CCT	p.P241P		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	241					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TGCGGTGAACGGGCCGATCAA	0.438			NA											124	313					0	0	0.00361	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399760	90399760	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:90399760T>G	uc001dnm.2	+	3	1558	c.1133T>G	c.(1132-1134)TTT>TGT	p.F378C	LRRC8D_uc001dnn.2_Missense_Mutation_p.F378C	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	378	Helical; (Potential).					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GTTTATGGCTTTATCTGCCTC	0.368			NA											19	164					0	0	0.006122	0	0
ABCA4	24	broad.mit.edu	37	1	94496568	94496568	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:94496568G>T	uc001dqh.2	-	28	4341	c.4237C>A	c.(4237-4239)CAG>AAG	p.Q1413K		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1413	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AAGGTGTACTGCTGCCCATAT	0.552			NA											10	49					0.000673444	0.000713271	0.008291	1	0
LPPR4	9890	broad.mit.edu	37	1	99772348	99772348	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:99772348A>T	uc001dse.2	+	7	2180	c.2074A>T	c.(2074-2076)AGC>TGC	p.S692C	LPPR4_uc010oue.1_Missense_Mutation_p.S634C	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	692							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CAACATTGATAGCAATGAGCA	0.507			NA											13	51					0	0	0.00245	0	0
S1PR1	1901	broad.mit.edu	37	1	101704717	101704717	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:101704717C>A	uc001dud.2	+	2	691	c.177C>A	c.(175-177)ATC>ATA	p.I59I	S1PR1_uc009weg.2_Silent_p.I59I	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	59	Helical; Name=1; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCTGCTTTATCATCCTGGAGA	0.458			NA									OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	113					1.07637e-12	1.50921e-12	0.004878	1	0
AMY1A	276	broad.mit.edu	37	1	104297213	104297213	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:104297213G>T	uc001duy.2	+	7	1185	c.971G>T	c.(970-972)GGA>GTA	p.G324V	AMY1A_uc001duz.2_Missense_Mutation_p.G324V	NM_001008221	NP_001008222	P04745	AMY1_HUMAN	salivary amylase alpha 1A precursor	324					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		GGCGCTGGAGGAGCCTCTATA	0.413	Pancreas(131;743 2392 43382 44986)		NA											36	249					4.60868e-44	9.24082e-44	0.00361	1	0
FAM40A	85369	broad.mit.edu	37	1	110584388	110584388	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:110584388A>T	uc001dza.1	+	8	809	c.790A>T	c.(790-792)ATC>TTC	p.I264F	FAM40A_uc001dyz.1_Missense_Mutation_p.I169F|FAM40A_uc009wfp.1_Missense_Mutation_p.I88F	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	264						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		GCCATTTGCCATCATGCTGTT	0.532			NA											75	258					0	0	0.00361	0	0
KCNC4	3749	broad.mit.edu	37	1	110754218	110754218	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:110754218G>T	uc001dzh.2	+	1	154	c.97G>T	c.(97-99)GAG>TAG	p.E33*	KCNC4_uc001dzf.2_Nonsense_Mutation_p.E33*|KCNC4_uc009wfr.2_Nonsense_Mutation_p.E33*|KCNC4_uc001dzg.2_Nonsense_Mutation_p.E33*|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	33	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGCCAAGGGCGAGGCGTCGGA	0.627			NA											12	39					5.50884e-06	6.07978e-06	0.001368	1	0
CHI3L2	1117	broad.mit.edu	37	1	111778693	111778693	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:111778693G>T	uc001eam.2	+	7	724	c.653G>T	c.(652-654)TGG>TTG	p.W218L	CHI3L2_uc001ean.2_Missense_Mutation_p.W208L|CHI3L2_uc001eao.2_Missense_Mutation_p.W139L|CHI3L2_uc009wga.2_Missense_Mutation_p.W139L	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	218					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		CATGGGTCTTGGGAAAAGCCC	0.512			NA											48	165					8.72198e-27	1.56916e-26	0.00361	1	0
SLC16A1	6566	broad.mit.edu	37	1	113456702	113456702	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:113456702G>A	uc001ecx.2	-	5	2146	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	SLC16A1_uc001ecy.2_Silent_p.F438F	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	438	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CCATGCCAATGAAGAGATAGA	0.398			NA											42	163					0	0	0.007835	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964605	119964605	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:119964605G>C	uc001ehs.2	+	3	1254	c.481G>C	c.(481-483)GCT>CCT	p.A161P	HSD3B2_uc001eht.2_Missense_Mutation_p.A161P|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	161					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CAAAAAGCTTGCTGAGAAGGC	0.502			NA											41	136					0	0	0.009718	0	0
C1orf56	54964	broad.mit.edu	37	1	151020974	151020974	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:151020974C>A	uc001ewn.2	+	1	716	c.651C>A	c.(649-651)ACC>ACA	p.T217T		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	217						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTCGGGCACCATGAGCCGGA	0.677	GBM(146;891 3320 6873)		NA									OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	171					4.6707e-30	8.76312e-30	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152277375	152277375	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:152277375G>C	uc001ezu.1	-	3	10023	c.9987C>G	c.(9985-9987)GAC>GAG	p.D3329E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3329	Filaggrin 20.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTCTACTGTCTCTGACTG	0.572			NA							Ichthyosis				228	650					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152282083	152282083	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:152282083C>G	uc001ezu.1	-	3	5315	c.5279G>C	c.(5278-5280)GGA>GCA	p.G1760A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1760	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAACGTCCAGACCTTTC	0.597			NA							Ichthyosis				223	394					0	0	0.00361	0	0
LCE1E	353135	broad.mit.edu	37	1	152759841	152759841	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:152759841C>T	uc001fan.2	+	2	119	c.66C>T	c.(64-66)CCC>CCT	p.P22P		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	22	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			agtgccctcccaagtgTCCCA	0.517			NA											97	259					0	0	0.00361	0	0
NUP210L	91181	broad.mit.edu	37	1	153995618	153995618	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:153995618C>T	uc001fdw.2	-	31	4350	c.4278G>A	c.(4276-4278)CAG>CAA	p.Q1426Q	NUP210L_uc009woq.2_Silent_p.Q335Q|NUP210L_uc010peh.1_Silent_p.Q1426Q	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1426						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCAGATAAAGCTGGGTATTGT	0.408			NA											41	135					0	0	0.00874	0	0
BCAN	63827	broad.mit.edu	37	1	156618448	156618448	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:156618448C>G	uc001fpp.2	+	6	1194	c.858C>G	c.(856-858)ACC>ACG	p.T286T	BCAN_uc001fpo.2_Silent_p.T286T	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	286	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGATTGCCACCACGGGCCAAC	0.607			NA											99	199					0	0	0.00361	0	0
SH2D2A	9047	broad.mit.edu	37	1	156784833	156784833	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:156784833G>T	uc001fqd.2	-	3	444	c.304C>A	c.(304-306)CGG>AGG	p.R102R	SH2D2A_uc001fqc.1_Silent_p.R74R|SH2D2A_uc009wsh.2_Silent_p.R102R|SH2D2A_uc001fqe.2_Silent_p.R84R|SH2D2A_uc010phs.1_Silent_p.R102R|NTRK1_uc001fqf.1_5'Flank|NTRK1_uc009wsi.1_5'Flank	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	102	SH2.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACTCACCTCCGGGTGATGAAG	0.637			NA											5	51					0.000602214	0.000638688	0.000602	1	0
KIRREL	55243	broad.mit.edu	37	1	158063219	158063219	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:158063219A>T	uc001frn.3	+	12	1966	c.1562A>T	c.(1561-1563)TAC>TTC	p.Y521F	KIRREL_uc010pib.1_Missense_Mutation_p.Y421F|KIRREL_uc009wsq.2_Missense_Mutation_p.Y357F|KIRREL_uc001fro.3_Missense_Mutation_p.Y335F	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	521	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					TTCTTCCTCTACCGGCGCCGC	0.602			NA											112	153					0	0	0.00361	0	0
CD1D	912	broad.mit.edu	37	1	158151904	158151904	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:158151904A>T	uc001frr.2	+	4	910	c.411A>T	c.(409-411)CAA>CAT	p.Q137H	CD1D_uc009wsr.1_Missense_Mutation_p.Q137H|CD1D_uc009wss.2_Missense_Mutation_p.Q137H|CD1D_uc009wst.1_Missense_Mutation_p.Q33H	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	137	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					TAGCATTTCAAGGAAAAGATA	0.512			NA											159	505					0	0	0.00361	0	0
SPTA1	6708	broad.mit.edu	37	1	158644393	158644393	+	Silent	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:158644393A>T	uc001fst.1	-	9	1384	c.1185T>A	c.(1183-1185)GCT>GCA	p.A395A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	395	Spectrin 5.			A -> G (in Ref. 3; AAA60575).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCAGCTCATCAGCATTGATCG	0.507			NA											101	232					0	0	0.00361	0	0
ATP1A4	480	broad.mit.edu	37	1	160146346	160146346	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:160146346T>A	uc001fve.3	+	17	3023	c.2544T>A	c.(2542-2544)GAT>GAA	p.D848E	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.D351E|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	848	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAAAGACGGATAATCTGGTGA	0.567			NA											25	70					0	0	0.003954	0	0
LY9	4063	broad.mit.edu	37	1	160784485	160784485	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:160784485C>A	uc001fwu.2	+	4	1056	c.1006C>A	c.(1006-1008)CAT>AAT	p.H336N	LY9_uc010pjs.1_Missense_Mutation_p.H336N|LY9_uc001fwv.2_Missense_Mutation_p.H336N|LY9_uc001fww.2_Missense_Mutation_p.H336N|LY9_uc001fwx.2_Missense_Mutation_p.H336N|LY9_uc001fwy.1_Missense_Mutation_p.H238N|LY9_uc001fwz.2_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	336	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CGGCCCCTACCATGCCTACGT	0.572			NA											29	68					9.80776e-20	1.59023e-19	0.00632	1	0
DPT	1805	broad.mit.edu	37	1	168670292	168670292	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:168670292T>A	uc001gfp.2	-	3	518	c.502A>T	c.(502-504)ATC>TTC	p.I168F		NM_001937	NP_001928	Q07507	DERM_HUMAN	dermatopontin precursor	168	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				ovary(1)	1	all_hematologic(923;0.208)					GCTCCTCGGATATAGTAATCA	0.443			NA											57	207					0	0	0.00361	0	0
SELP	6403	broad.mit.edu	37	1	169566297	169566297	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:169566297A>T	uc001ggi.3	-	11	1888	c.1823T>A	c.(1822-1824)CTG>CAG	p.L608Q	SELP_uc001ggh.2_Missense_Mutation_p.L443Q|SELP_uc009wvr.2_Missense_Mutation_p.L608Q	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	608	Extracellular (Potential).|Sushi 7.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GGGCCCCTCCAGCTTAAAGCC	0.483			NA											15	138					0	0	0.003163	0	0
C1orf9	51430	broad.mit.edu	37	1	172558355	172558355	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:172558355G>T	uc001giq.3	+	18	2430	c.2114G>T	c.(2113-2115)AGT>ATT	p.S705I	C1orf9_uc010pmm.1_Missense_Mutation_p.S705I|C1orf9_uc009wwd.2_Missense_Mutation_p.S661I|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	705					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		TTAAGTAGTAGTATGCACCAG	0.388	Colon(43;174 953 11768 38880 47057)		NA											75	165					1.15074e-40	2.27264e-40	0.00361	1	0
PAPPA2	60676	broad.mit.edu	37	1	176738883	176738883	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:176738883C>T	uc001gkz.2	+	16	5628	c.4464C>T	c.(4462-4464)CGC>CGT	p.R1488R	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1488	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTCTGAAACGCTGCTCAATCT	0.522			NA											22	222					0	0	0.001882	0	0
ASTN1	460	broad.mit.edu	37	1	176927497	176927497	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:176927497C>G	uc001glc.2	-	10	1932	c.1720G>C	c.(1720-1722)GAT>CAT	p.D574H	ASTN1_uc001glb.1_Missense_Mutation_p.D574H|ASTN1_uc001gld.1_Missense_Mutation_p.D574H|ASTN1_uc009wwx.1_Missense_Mutation_p.D574H	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	582					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCACAGCATCCTCCATCACA	0.532			NA											34	86					0	0	0.003755	0	0
ASTN1	460	broad.mit.edu	37	1	176998824	176998824	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:176998824C>G	uc001glc.2	-	5	1278	c.1066G>C	c.(1066-1068)GAC>CAC	p.D356H	ASTN1_uc001glb.1_Missense_Mutation_p.D356H|ASTN1_uc001gld.1_Missense_Mutation_p.D356H|ASTN1_uc009wwx.1_Missense_Mutation_p.D356H|ASTN1_uc001gle.3_RNA|MIR488_hsa-mir-488|MI0003123_5'Flank	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	356					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AGCTGGGGGTCGTTTTCTGCC	0.507			NA											21	70					0	0	0.001882	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885793	180885793	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:180885793C>T	uc001gok.2	+	2	621	c.554C>T	c.(553-555)CCG>CTG	p.P185L		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	185										ovary(3)|skin(1)	4						AGGGGGAGCCCGTGGCCTCCA	0.642			NA											46	148					0	0	0.00361	0	0
CACNA1E	777	broad.mit.edu	37	1	181546938	181546938	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:181546938C>A	uc001gow.2	+	4	714	c.549C>A	c.(547-549)CAC>CAA	p.H183Q	CACNA1E_uc009wxr.2_Missense_Mutation_p.H90Q|CACNA1E_uc009wxs.2_Missense_Mutation_p.H90Q	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	183	I.|Extracellular (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCAATACTCACGTGGACCTGA	0.552			NA											12	28					7.03913e-09	8.48139e-09	0.001368	1	0
C1orf25	81627	broad.mit.edu	37	1	185106753	185106753	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:185106753C>G	uc001grf.3	-	10	1770	c.1498G>C	c.(1498-1500)GGT>CGT	p.G500R	C1orf25_uc010pon.1_Missense_Mutation_p.G344R	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	500						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						ACCATATTACCATCCTTCTGA	0.348			NA											11	170					0	0	0.008291	0	0
HMCN1	83872	broad.mit.edu	37	1	185959564	185959564	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:185959564G>A	uc001grq.1	+	22	3595	c.3366G>A	c.(3364-3366)CCG>CCA	p.P1122P	HMCN1_uc001grr.1_Silent_p.P463P	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1122	Ig-like C2-type 8.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCATCTCACCGTTCTCTCCAA	0.468			NA											53	126					0	0	0.00361	0	0
HMCN1	83872	broad.mit.edu	37	1	186114898	186114898	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:186114898G>T	uc001grq.1	+	93	14680	c.14451G>T	c.(14449-14451)TGG>TGT	p.W4817C	HMCN1_uc001grs.1_Missense_Mutation_p.W386C	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4817	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGGAAGTTGGGGAAGCTGGC	0.502			NA											33	119					2.35958e-20	3.87365e-20	0.009718	1	0
KCNT2	343450	broad.mit.edu	37	1	196197364	196197364	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:196197364G>T	uc001gtd.1	-	28	3458	c.3398C>A	c.(3397-3399)ACT>AAT	p.T1133N	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.T1066N|KCNT2_uc001gtf.1_Missense_Mutation_p.T1109N|KCNT2_uc001gtg.1_RNA	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1133	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCAAAGTTGAGTTTCCTCCCG	0.398			NA											10	49					1.76689e-08	2.0843e-08	0.006214	1	0
PTPRC	5788	broad.mit.edu	37	1	198721475	198721475	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:198721475G>T	uc001gur.1	+	30	3479	c.3299G>T	c.(3298-3300)CGT>CTT	p.R1100L	PTPRC_uc001gus.1_Missense_Mutation_p.R1052L|PTPRC_uc001gut.1_Missense_Mutation_p.R939L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1100	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TATACCCTTCGTGTCTTTGAA	0.358			NA											16	86					4.14922e-12	5.66652e-12	0.004007	1	0
PPFIA4	8497	broad.mit.edu	37	1	203024729	203024729	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:203024729G>T	uc001gyz.2	+	3	1074	c.481G>T	c.(481-483)GGC>TGC	p.G161C	PPFIA4_uc009xaj.2_Missense_Mutation_p.G792C|PPFIA4_uc010pqf.1_Missense_Mutation_p.G374C|PPFIA4_uc001gza.2_Missense_Mutation_p.G161C|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	161					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						ACCACTCAGCGGCCGCTCCAC	0.662			NA											12	55					3.32936e-07	3.77487e-07	0.006122	1	0
PLEKHA6	22874	broad.mit.edu	37	1	204237428	204237428	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:204237428C>T	uc001hau.2	-	4	432	c.115G>A	c.(115-117)GCC>ACC	p.A39T		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	39										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCTTTGCGGGCTGTGCGAGTT	0.602			NA											11	54					0	0	0.000978	0	0
NUAK2	81788	broad.mit.edu	37	1	205290708	205290708	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:205290708C>G	uc001hce.2	-	1	176	c.49G>C	c.(49-51)GCA>CCA	p.A17P		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	17					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCTAGCTCTGCGGCCGAGGGA	0.677			NA											11	21					0	0	0.008291	0	0
MFSD4	148808	broad.mit.edu	37	1	205538353	205538353	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:205538353G>C	uc001hcv.3	+	1	242	c.156G>C	c.(154-156)CAG>CAC	p.Q52H	MFSD4_uc010prk.1_Missense_Mutation_p.Q52H|MFSD4_uc010prl.1_RNA	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	52					transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CGCTGCCCCAGATCTCCTGGG	0.632			NA											5	10					0	0	0.001984	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713410	222713410	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:222713410C>A	uc001hnh.1	-	4	1450	c.1392G>T	c.(1390-1392)TGG>TGT	p.W464C		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	464					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCTTTGCTCTCCAGCCATAGT	0.488			NA											47	148					3.21987e-24	5.62585e-24	0.00361	1	0
C1orf55	163859	broad.mit.edu	37	1	226176062	226176062	+	Silent	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:226176062T>G	uc001hpu.3	-	6	722	c.669A>C	c.(667-669)GCA>GCC	p.A223A	C1orf55_uc001hpv.2_Silent_p.A223A	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	223										lung(1)	1	Breast(184;0.197)					TGGACCCTTCTGCAGTCTCTA	0.423			NA											58	131					0	0	0.00361	0	0
ITPKB	3707	broad.mit.edu	37	1	226822507	226822507	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:226822507C>A	uc010pvo.1	-	8	3046	c.2706G>T	c.(2704-2706)ACG>ACT	p.T902T		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	902							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CAGGCAGGGGCGTGGTTTTCC	0.597	Colon(84;110 1851 5306 33547)		NA											18	49					1.33834e-09	1.64269e-09	0.007413	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227219083	227219083	+	Silent	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:227219083T>G	uc001hqr.2	-	27	4529	c.3586A>C	c.(3586-3588)AGA>CGA	p.R1196R	CDC42BPA_uc001hqq.2_Silent_p.R495R|CDC42BPA_uc001hqs.2_Silent_p.R1115R|CDC42BPA_uc009xes.2_Silent_p.R1168R|CDC42BPA_uc010pvs.1_Silent_p.R1176R|CDC42BPA_uc001hqp.2_Silent_p.R352R|CDC42BPA_uc001hqt.2_Silent_p.R74R|CDC42BPA_uc001hqu.1_Silent_p.R403R	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1209					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				GAGCGGTCTCTGAATTTGTTT	0.418			NA											147	234					0	0	0.00361	0	0
OBSCN	84033	broad.mit.edu	37	1	228509335	228509335	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:228509335G>C	uc009xez.1	+	55	14837	c.14793G>C	c.(14791-14793)TGG>TGC	p.W4931C	OBSCN_uc001hsn.2_Missense_Mutation_p.W4931C	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4931	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGCCCGCTGGCTGAAGGATG	0.637			NA											19	56					0	0	0.006122	0	0
ACTA1	58	broad.mit.edu	37	1	229568343	229568343	+	Silent	SNP	G	G	T	rs121909526		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:229568343G>T	uc001htm.2	-	3	519	c.414C>A	c.(412-414)ATC>ATA	p.I138I		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	138			I -> M (in NEM3; autosomal recessive).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GCACGGCCTGGATGGCCACGT	0.498			NA											54	81					7.50695e-29	1.38212e-28	0.00361	1	0
NID1	4811	broad.mit.edu	37	1	236192920	236192920	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:236192920C>A	uc001hxo.2	-	7	1770	c.1668G>T	c.(1666-1668)GTG>GTT	p.V556V	NID1_uc009xgd.2_Silent_p.V556V	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	556	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAATCTGCGGCACGCGGCCCT	0.642			NA											7	19					3.86212e-05	4.16897e-05	0.008291	1	0
ACTN2	88	broad.mit.edu	37	1	236907995	236907995	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:236907995G>T	uc001hyf.2	+	12	1529	c.1325G>T	c.(1324-1326)CGG>CTG	p.R442L	ACTN2_uc001hyg.2_Missense_Mutation_p.R234L|ACTN2_uc009xgi.1_Missense_Mutation_p.R442L|ACTN2_uc010pxu.1_Missense_Mutation_p.R131L|ACTN2_uc001hyh.2_Missense_Mutation_p.R130L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	442	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCTCTGCTGCGGAAGCACGAG	0.592			NA											19	76					4.63292e-17	7.15832e-17	0.008871	1	0
ZP4	57829	broad.mit.edu	37	1	238053457	238053457	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:238053457G>T	uc001hym.2	-	2	195	c.195C>A	c.(193-195)CAC>CAA	p.H65Q	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	65	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCTGCAGCTCGTGCAGCAGCC	0.552	NSCLC(166;160 2029 11600 18754 19936)		NA											47	135					8.86878e-18	1.40052e-17	0.00361	1	0
FMN2	56776	broad.mit.edu	37	1	240255646	240255646	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:240255646G>T	uc010pyd.1	+	1	462	c.237G>T	c.(235-237)CGG>CGT	p.R79R	FMN2_uc010pye.1_Silent_p.R79R	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	79					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCAACCTGCGGATCAGGAAGA	0.552			NA											10	42					4.3838e-07	4.95615e-07	0.001855	1	0
NLRP3	114548	broad.mit.edu	37	1	247587961	247587961	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:247587961T>C	uc001icr.2	+	5	1354	c.1216T>C	c.(1216-1218)TTC>CTC	p.F406L	NLRP3_uc001ics.2_Missense_Mutation_p.F406L|NLRP3_uc001icu.2_Missense_Mutation_p.F406L|NLRP3_uc001icw.2_Missense_Mutation_p.F406L|NLRP3_uc001icv.2_Missense_Mutation_p.F406L|NLRP3_uc010pyw.1_Missense_Mutation_p.F404L|NLRP3_uc001ict.1_Missense_Mutation_p.F404L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	406	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CGAGGTCCTCTTCACCATGTG	0.532			NA											27	133					0	0	0.004656	0	0
OR13G1	441933	broad.mit.edu	37	1	247835510	247835510	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:247835510C>A	uc001idi.1	-	1	834	c.834G>T	c.(832-834)GTG>GTT	p.V278V		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGTGGGAGTCACAAGAGTAT	0.438			NA											60	112					1.1362e-29	2.12162e-29	0.00361	1	0
TRIM58	25893	broad.mit.edu	37	1	248028078	248028078	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:248028078G>A	uc001ido.2	+	3	636	c.588G>A	c.(586-588)GAG>GAA	p.E196E		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	196	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGCCCAGGAGGAGCAACGGC	0.612			NA											5	64					0	0	0.004482	0	0
OR2L8	391190	broad.mit.edu	37	1	248112202	248112202	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:248112202G>T	uc001idt.1	+	1	43	c.43G>T	c.(43-45)GGG>TGG	p.G15W	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATCTTATTGGGGCTGTTTCC	0.358			NA											55	167					5.73376e-24	9.97395e-24	0.00361	1	0
OR14I1	401994	broad.mit.edu	37	1	248844970	248844970	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:248844970C>A	uc001ieu.1	-	1	636	c.636G>T	c.(634-636)ATG>ATT	p.M212I		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	212	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGAGATCATCATGAGAATAA	0.493			NA											49	95					4.10826e-27	7.44209e-27	0.00361	1	0
OR14I1	401994	broad.mit.edu	37	1	248845065	248845065	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:248845065G>A	uc001ieu.1	-	1	541	c.541C>T	c.(541-543)CAT>TAT	p.H181Y		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCAACACATGAGGGATGTCA	0.502			NA											7	98					0	0	0.001984	0	0
RBM17	84991	broad.mit.edu	37	10	6157491	6157491	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:6157491G>C	uc001ijb.2	+	12	1404	c.1178G>C	c.(1177-1179)AGG>ACG	p.R393T	RBM17_uc010qav.1_Missense_Mutation_p.R393T|RBM17_uc001ijc.2_RNA	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	393					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						GACAAATTCAGGGTCTTGGAT	0.408			NA											38	167					0	0	0.005524	0	0
GATA3	2625	broad.mit.edu	37	10	8105983	8105983	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:8105983C>A	uc001ika.2	+	4	1360	c.803C>A	c.(802-804)GCA>GAA	p.A268E	GATA3_uc001ijz.2_Missense_Mutation_p.A269E	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	268	GATA-type 1.				aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						AACTGTGGGGCAACCTCGACC	0.552			NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						30	121					2.81731e-10	3.54074e-10	0.002096	1	0
ITGA8	8516	broad.mit.edu	37	10	15628598	15628598	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:15628598T>A	uc001ioc.1	-	23	2357	c.2357A>T	c.(2356-2358)CAG>CTG	p.Q786L	ITGA8_uc010qcb.1_Missense_Mutation_p.Q771L	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	786	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TATTTCCACCTGCGCTACAGC	0.368			NA											14	54					0	0	0.006122	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24889599	24889599	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:24889599C>A	uc001isb.2	-	14	3595	c.3108G>T	c.(3106-3108)CAG>CAT	p.Q1036H	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.Q1036H|ARHGAP21_uc010qdc.1_Missense_Mutation_p.Q871H	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1035	Interaction with ARF1 and ARF6.|PH.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TGCTGCTCTCCTGGATCGTCT	0.443			NA											25	131					1.66031e-10	2.1136e-10	0.003954	1	0
ALOX5	240	broad.mit.edu	37	10	45938974	45938974	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:45938974G>A	uc001jce.2	+	11	1661	c.1562G>A	c.(1561-1563)CGC>CAC	p.R521H	ALOX5_uc009xmt.2_Missense_Mutation_p.R489H|ALOX5_uc010qfg.1_Missense_Mutation_p.R521H	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	521	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	ATGCGGGGCCGCAAGTCCTCA	0.692			NA											4	32					0	0	0.009096	0	0
PPYR1	5540	broad.mit.edu	37	10	47087824	47087824	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:47087824G>A	uc001jee.2	+	3	1460	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.E347E	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	347	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						CCCCCCTGGAGGAGTCGGAGC	0.557			NA											21	147					0	0	0.010504	0	0
ASAH2	56624	broad.mit.edu	37	10	51978271	51978271	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:51978271T>A	uc001jjd.2	-	7	1013	c.1013A>T	c.(1012-1014)CAG>CTG	p.Q338L	ASAH2_uc009xos.2_Missense_Mutation_p.Q338L	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	338	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						AATTCTCACCTGTCCAGGTAG	0.393			NA											30	31					0	0	0.00361	0	0
EGR2	1959	broad.mit.edu	37	10	64575716	64575716	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:64575716A>G	uc010qim.1	-	2	228	c.74T>C	c.(73-75)ATC>ACC	p.I25T	EGR2_uc010qin.1_5'UTR|EGR2_uc001jmi.2_Missense_Mutation_p.I25T|EGR2_uc010qio.1_Missense_Mutation_p.I38T|EGR2_uc009xph.2_Missense_Mutation_p.I25T	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	25					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CACCGGGTAGATGTTGTCAGA	0.572			NA											74	140					0	0	0.00361	0	0
POLR3A	11128	broad.mit.edu	37	10	79784770	79784770	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:79784770C>A	uc001jzn.2	-	4	543	c.449G>T	c.(448-450)TGC>TTC	p.C150F		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	150					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TTTCTTCCGGCACTTGTCAGA	0.468			NA											43	76					7.53189e-24	1.30442e-23	0.007835	1	0
PAX2	5076	broad.mit.edu	37	10	102509514	102509514	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:102509514G>A	uc001krk.3	+	2	605	c.55G>A	c.(55-57)GGT>AGT	p.G19S	PAX2_uc001krl.3_Missense_Mutation_p.G19S|PAX2_uc001krm.3_Missense_Mutation_p.G19S|PAX2_uc001kro.3_Missense_Mutation_p.G19S|PAX2_uc001krn.3_Missense_Mutation_p.G19S|PAX2_uc010qps.1_Missense_Mutation_p.G18S|PAX2_uc001krp.1_Missense_Mutation_p.G23S	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	19	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		AGGGCACGGGGGTGTGAACCA	0.672			NA											22	48					0	0	0.00333	0	0
BTRC	8945	broad.mit.edu	37	10	103291028	103291028	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:103291028G>T	uc001kta.2	+	7	891	c.778G>T	c.(778-780)GGG>TGG	p.G260W	BTRC_uc001ktb.2_Missense_Mutation_p.G224W|BTRC_uc001ktc.2_Missense_Mutation_p.G234W	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	260					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		ACCTCCTGACGGGAATGCTCC	0.313			NA											32	121					2.32173e-10	2.93664e-10	0.004878	1	0
SORCS3	22986	broad.mit.edu	37	10	106960961	106960961	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:106960961A>G	uc001kyi.1	+	16	2438	c.2211A>G	c.(2209-2211)TCA>TCG	p.S737S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	737	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GAGACCACTCAGGATCAGTGG	0.493	NSCLC(116;1497 1690 7108 13108 14106)		NA											53	114					0	0	0.00361	0	0
ATRNL1	26033	broad.mit.edu	37	10	116930936	116930936	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:116930936G>A	uc001lcg.2	+	8	1620	c.1234G>A	c.(1234-1236)GAG>AAG	p.E412K	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.E412K|ATRNL1_uc009xyq.2_Nonsense_Mutation_p.W382*	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	412	Kelch 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTATGCTGTGGAGGGACATTC	0.373			NA											48	104					0	0	0.00361	0	0
VAX1	11023	broad.mit.edu	37	10	118896117	118896117	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:118896117G>A	uc009xyx.2	-	2	540	c.295C>T	c.(295-297)CGG>TGG	p.R99W	VAX1_uc001ldb.1_Missense_Mutation_p.R99W	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	99						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		CTCTTAGGCCGGTCCAAGTCC	0.657			NA											9	57					0	0	0.000978	0	0
CPXM2	119587	broad.mit.edu	37	10	125528162	125528162	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:125528162C>A	uc001lhk.1	-	9	1504	c.1179G>T	c.(1177-1179)GTG>GTT	p.V393V	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	393					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		ACACGAACTGCACCAGCAGCA	0.627			NA											43	120					2.24722e-20	3.69689e-20	0.00361	1	0
STK32C	282974	broad.mit.edu	37	10	134040330	134040330	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr10:134040330C>A	uc001lle.1	-	4	753	c.613G>T	c.(613-615)GAC>TAC	p.D205Y	STK32C_uc001lld.1_Missense_Mutation_p.D88Y|STK32C_uc010quu.1_Missense_Mutation_p.D218Y|STK32C_uc009ybc.1_Missense_Mutation_p.D88Y|STK32C_uc009ybd.1_Missense_Mutation_p.D88Y|STK32C_uc001llb.2_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	205	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CGCAGGTAGTCCAGAGCCAGT	0.642			NA											20	60					7.45023e-12	1.00699e-11	0.010504	1	0
LRRC56	115399	broad.mit.edu	37	11	552165	552165	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:552165G>T	uc010qvz.1	+	12	1619	c.1114G>T	c.(1114-1116)GAC>TAC	p.D372Y		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	372										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCAGAGCCTGACCCTGCAGA	0.662			NA											30	45					3.1745e-13	4.51535e-13	0.008361	1	0
MUC2	4583	broad.mit.edu	37	11	1103934	1103934	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:1103934A>T	uc001lsx.1	+	51	15346	c.15319A>T	c.(15319-15321)ATG>TTG	p.M5107L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	5107	CTCK.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GACATTTGTCATGTGAGTCCC	0.672			NA											2	1					0	0	0.004672	0	0
OR51B2	79345	broad.mit.edu	37	11	5345155	5345155	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:5345155G>T	uc001mao.1	-	1	428	c.373C>A	c.(373-375)CGC>AGC	p.R125S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGGATTGCGGATGGCAATG	0.453			NA											34	55					8.4185e-14	1.20834e-13	0.002445	1	0
OLFML1	283298	broad.mit.edu	37	11	7531356	7531356	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:7531356C>A	uc001mfi.2	+	3	1498	c.1146C>A	c.(1144-1146)GCC>GCA	p.A382A	OLFML1_uc010raz.1_Silent_p.A246A|OLFML1_uc010rba.1_Silent_p.A382A	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	382	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AGCTCTATGCCTGGAATGAAG	0.463			NA											23	46					7.41877e-09	8.89882e-09	0.001882	1	0
NELL1	4745	broad.mit.edu	37	11	20948973	20948973	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:20948973G>C	uc001mqe.2	+	8	1032	c.879G>C	c.(877-879)AGG>AGC	p.R293S	NELL1_uc001mqf.2_Missense_Mutation_p.R293S|NELL1_uc009yid.2_Missense_Mutation_p.R321S|NELL1_uc010rdo.1_Missense_Mutation_p.R236S|NELL1_uc010rdp.1_Missense_Mutation_p.R53S	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	293	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACCATTGCAGGAACTGCACTT	0.383			NA											12	48					0	0	0.000978	0	0
ANO5	203859	broad.mit.edu	37	11	22248963	22248963	+	Missense_Mutation	SNP	G	G	A	rs150652958		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:22248963G>A	uc001mqi.2	+	7	796	c.479G>A	c.(478-480)CGC>CAC	p.R160H	ANO5_uc001mqj.2_Missense_Mutation_p.R159H	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	160	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GATATTCCCCGCCCTAAGCAC	0.433			NA											50	104					0	0	0.00361	0	0
SLC5A12	159963	broad.mit.edu	37	11	26700315	26700315	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:26700315C>A	uc001mra.2	-	13	1836	c.1523G>T	c.(1522-1524)AGT>ATT	p.S508I	SLC5A12_uc001mrb.2_RNA	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	508	Helical; (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						GCCCACTGCACTGTAGTAAAG	0.463			NA											44	86					7.05121e-23	1.20008e-22	0.002522	1	0
BBOX1	8424	broad.mit.edu	37	11	27147256	27147256	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:27147256A>T	uc001mre.1	+	8	1260	c.892A>T	c.(892-894)ACA>TCA	p.T298S	BBOX1_uc009yih.1_Missense_Mutation_p.T298S|BBOX1_uc001mrg.1_Missense_Mutation_p.T298S	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	298					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	aactagggacacaatatttga	0.129			NA											11	22					0	0	0.008291	0	0
LMO2	4005	broad.mit.edu	37	11	33886333	33886333	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:33886333G>A	uc001mve.2	-	2	511	c.72C>T	c.(70-72)CCC>CCT	p.P24P	LMO2_uc001mvc.2_Silent_p.P17P|LMO2_uc001mvd.2_Silent_p.P17P|LMO2_uc010rel.1_Silent_p.P24P|LMO2_uc010rem.1_Silent_p.P93P	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	24					multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						GCAGGGATGGGGGGATCTGCA	0.617			NA	T	TRD@	T-ALL								9	70					0	0	0.001368	0	0
TTC17	55761	broad.mit.edu	37	11	43411214	43411214	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:43411214G>T	uc001mxi.2	+	3	276	c.262G>T	c.(262-264)GCT>TCT	p.A88S	TTC17_uc001mxh.2_Missense_Mutation_p.A88S|TTC17_uc010rfj.1_Missense_Mutation_p.A31S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	88							binding			ovary(5)	5						ACAATTAGTTGCTCAAAAAAT	0.383			NA											28	75					2.25844e-05	2.46489e-05	0.007291	1	0
OR4A15	81328	broad.mit.edu	37	11	55136164	55136164	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55136164G>T	uc010rif.1	+	1	805	c.805G>T	c.(805-807)GCA>TCA	p.A269S		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	269	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTACACCTGTGCATCCCACGT	0.423			NA											69	232					1.72039e-30	3.251e-30	0.00361	1	0
OR4C6	219432	broad.mit.edu	37	11	55432926	55432926	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55432926G>C	uc001nht.3	+	3	549	c.284G>C	c.(283-285)TGC>TCC	p.C95S	OR4C6_uc010rik.1_Missense_Mutation_p.C95S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTCAAAGGCTGCCTCACCCAG	0.527			NA											40	160					0	0	0.00623	0	0
OR4C6	219432	broad.mit.edu	37	11	55433526	55433526	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55433526C>A	uc001nht.3	+	3	1149	c.884C>A	c.(883-885)GCC>GAC	p.A295D	OR4C6_uc010rik.1_Missense_Mutation_p.A295D	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GTGAAAAGTGCCATGAAGAAA	0.433			NA											20	79					2.94398e-08	3.44704e-08	0.007413	1	0
OR5D16	390144	broad.mit.edu	37	11	55607101	55607101	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55607101T>A	uc010rio.1	+	1	874	c.874T>A	c.(874-876)TAC>AAC	p.Y292N		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TCCCCTGATCTACAGTCTGAG	0.378			NA											27	90					0	0	0.004656	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735298	55735298	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55735298G>A	uc010rit.1	-	1	642	c.642C>T	c.(640-642)TCC>TCT	p.S214S		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	214	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TCAAAATGTTGGAGATAATTT	0.393			NA											20	49					0	0	0.007413	0	0
OR8K5	219453	broad.mit.edu	37	11	55927268	55927268	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:55927268G>T	uc010rja.1	-	1	526	c.526C>A	c.(526-528)CAT>AAT	p.H176N		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CAGTAAAAATGACTGATGACA	0.358			NA											27	98					4.87955e-14	7.01659e-14	0.005443	1	0
OR5T3	390154	broad.mit.edu	37	11	56020456	56020456	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:56020456G>C	uc010rjd.1	+	1	781	c.781G>C	c.(781-783)GCT>CCT	p.A261P		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	261	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					GATGCATTCTGCTAAGGGAAG	0.408			NA											76	252					0	0	0.00361	0	0
OR5M1	390168	broad.mit.edu	37	11	56380871	56380871	+	Silent	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:56380871T>A	uc001nja.1	-	1	108	c.108A>T	c.(106-108)CTA>CTT	p.L36L		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CCAGTGTGATTAGGTAGATCG	0.498			NA											48	149					0	0	0.00361	0	0
OR9G4	283189	broad.mit.edu	37	11	56511222	56511222	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:56511222G>T	uc010rjo.1	-	1	66	c.66C>A	c.(64-66)ACC>ACA	p.T22T		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CAGTCAGGATGGTGCAATTTC	0.423			NA											22	79					5.26018e-13	7.44169e-13	0.001882	1	0
OR5B12	390191	broad.mit.edu	37	11	58207543	58207543	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:58207543C>A	uc010rkh.1	-	1	82	c.82G>T	c.(82-84)GTC>TTC	p.V28F		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AAAAGGAAGACTATGAAGAGT	0.468			NA											34	88					2.47316e-13	3.53052e-13	0.003271	1	0
GLYATL2	219970	broad.mit.edu	37	11	58604550	58604550	+	Silent	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:58604550T>C	uc001nnd.3	-	5	545	c.414A>G	c.(412-414)CCA>CCG	p.P138P	GLYATL2_uc009ymq.2_Silent_p.P138P	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	138						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TGTGTTTCTTTGGTAATTCCG	0.378			NA											45	158					0	0	0.009718	0	0
GLYATL2	219970	broad.mit.edu	37	11	58605833	58605833	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:58605833G>T	uc001nnd.3	-	3	218	c.87C>A	c.(85-87)GGC>GGA	p.G29G	GLYATL2_uc009ymq.2_Silent_p.G29G	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	29						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TGAAAATGGCGCCATATACCT	0.418			NA											13	41					2.27111e-07	2.59367e-07	0.001368	1	0
MS4A4A	51338	broad.mit.edu	37	11	60064675	60064675	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:60064675G>T	uc001noz.2	+	3	217	c.207G>T	c.(205-207)GTG>GTT	p.V69V	MS4A4A_uc001npa.2_Silent_p.V50V|MS4A4A_uc001npb.2_Silent_p.V50V|MS4A4A_uc001npc.2_Silent_p.V50V	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	69	Helical; (Potential).					integral to membrane	receptor activity				0						TTTAGGTTGTGCAGATTCTGA	0.423			NA											36	112					1.836e-18	2.91687e-18	0.003755	1	0
INTS5	80789	broad.mit.edu	37	11	62415695	62415695	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:62415695C>A	uc001nud.2	-	2	1910	c.1857G>T	c.(1855-1857)GAG>GAT	p.E619D	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	619					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CAGCTACTTCCTCCTCAGGAT	0.617			NA											17	63					3.41278e-10	4.27547e-10	0.00499	1	0
SLC22A6	9356	broad.mit.edu	37	11	62751943	62751943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:62751943G>A	uc001nwk.2	-	1	527	c.220C>T	c.(220-222)CAG>TAG	p.Q74*	SLC22A6_uc001nwl.2_Nonsense_Mutation_p.Q74*|SLC22A6_uc001nwj.2_Nonsense_Mutation_p.Q74*|SLC22A6_uc001nwm.2_Nonsense_Mutation_p.Q74*	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	74	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GACTCAGGCTGCCCCTGCCTG	0.677			NA											16	41					0	0	0.007413	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64606195	64606195	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:64606195A>G	uc001obs.3	-	8	1056	c.1056T>C	c.(1054-1056)TAT>TAC	p.Y352Y		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	352	AGC-kinase C-terminal.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GCTCAGGAATATAGGGGGCCG	0.617			NA											24	100					0	0	0.00333	0	0
SYT12	91683	broad.mit.edu	37	11	66812117	66812117	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:66812117C>A	uc009yrl.2	+	6	1121	c.891C>A	c.(889-891)GCC>GCA	p.A297A	SYT12_uc001oju.2_Silent_p.A297A	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	297	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						TCCCCACAGCCGAGCGCCTCA	0.662	Ovarian(65;2862 3307)		NA											29	93					7.01153e-11	9.08732e-11	0.007291	1	0
PPP1CA	5499	broad.mit.edu	37	11	67168577	67168577	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:67168577G>T	uc001okw.1	-	2	272	c.149C>A	c.(148-150)CCC>CAC	p.P50H	PPP1CA_uc009yro.1_5'UTR|PPP1CA_uc001okt.1_Missense_Mutation_p.P55H|PPP1CA_uc001oku.1_Missense_Mutation_p.P61H|PPP1CA_uc001okv.1_Intron|PPP1CA_uc001okx.1_Missense_Mutation_p.P138H|PPP1CA_uc001oky.2_Missense_Mutation_p.P50H|TBC1D10C_uc001okz.2_5'Flank|TBC1D10C_uc001ola.2_5'Flank	NM_002708	NP_002699	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha	50					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			CAGAAGAATGGGCTGGCTCAG	0.612			NA											26	68					2.48779e-11	3.27276e-11	0.005443	1	0
KCTD14	65987	broad.mit.edu	37	11	77727720	77727720	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:77727720G>A	uc001oyw.3	-	2	712	c.687C>T	c.(685-687)TTC>TTT	p.F229F		NM_023930	NP_076419	Q9BQ13	KCD14_HUMAN	potassium channel tetramerisation domain	229						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			AGAACTTGGAGAATACCTTGT	0.493	NSCLC(86;414 1416 18100 32729 49271)|Esophageal Squamous(156;1132 1858 11406 36132 46748)		NA											30	114					0	0	0.008361	0	0
ODZ4	26011	broad.mit.edu	37	11	78369779	78369779	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:78369779G>A	uc001ozl.3	-	34	8097	c.7634C>T	c.(7633-7635)TCC>TTC	p.S2545F	ODZ4_uc001ozk.3_Missense_Mutation_p.S770F|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2545	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GGTGATTGTGGAGCCATAGAG	0.537			NA											37	85					0	0	0.004289	0	0
ODZ4	26011	broad.mit.edu	37	11	78380866	78380866	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:78380866C>A	uc001ozl.3	-	32	6987	c.6524G>T	c.(6523-6525)CGA>CTA	p.R2175L	ODZ4_uc001ozk.3_Missense_Mutation_p.R400L|ODZ4_uc009yvb.1_Missense_Mutation_p.R759L	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2175	YD 17.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTTCACTACTCGCCCCATGTT	0.498			NA											15	46					1.15088e-07	1.32393e-07	0.004007	1	0
C11orf82	220042	broad.mit.edu	37	11	82645123	82645123	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:82645123G>T	uc001ozt.2	+	6	2987	c.2743G>T	c.(2743-2745)GGT>TGT	p.G915C	C11orf82_uc010rsr.1_Missense_Mutation_p.G614C|C11orf82_uc010rss.1_Missense_Mutation_p.G614C|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	915					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						AACCAATAAAGGTTTAATTAA	0.343			NA											18	57					2.35188e-11	3.10433e-11	0.006122	1	0
FAT3	120114	broad.mit.edu	37	11	92620173	92620173	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:92620173G>A	uc001pdj.3	+	24	12962	c.12945G>A	c.(12943-12945)GGG>GGA	p.G4315G	FAT3_uc001pdi.3_Silent_p.G755G	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4315	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGACAAAGGGGTTGATGACC	0.493			NA								TCGA Ovarian(4;0.039)			8	14					0	0	0.00308	0	0
GPR83	10888	broad.mit.edu	37	11	94134234	94134234	+	Silent	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:94134234G>C	uc001pet.2	-	1	352	c.180C>G	c.(178-180)CGC>CGG	p.R60R		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	60	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAGCGCCGTAGCGCCTCCTGC	0.582			NA											21	60					0	0	0.010504	0	0
CNTN5	53942	broad.mit.edu	37	11	99941253	99941253	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:99941253G>T	uc001pga.2	+	11	1599	c.1260G>T	c.(1258-1260)ACG>ACT	p.T420T	CNTN5_uc009ywv.1_Silent_p.T420T|CNTN5_uc001pfz.2_Silent_p.T420T|CNTN5_uc001pgb.2_Silent_p.T346T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	420	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCAGACCCACGTATCGTTGGC	0.478			NA											11	42					3.07112e-06	3.42297e-06	0.000978	1	0
CNTN5	53942	broad.mit.edu	37	11	99945012	99945012	+	Silent	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:99945012T>C	uc001pga.2	+	13	1905	c.1566T>C	c.(1564-1566)GTT>GTC	p.V522V	CNTN5_uc009ywv.1_Silent_p.V522V|CNTN5_uc001pfz.2_Silent_p.V522V|CNTN5_uc001pgb.2_Silent_p.V448V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	522	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACAGAGCAGTTAGAGAAAACA	0.363			NA											4	16					0	0	0.000602	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103128358	103128358	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:103128358C>T	uc001pho.2	+	69	10627	c.10483C>T	c.(10483-10485)CTG>TTG	p.L3495L	DYNC2H1_uc001phn.1_Silent_p.L3502L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3495					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTATCTCCCCCTGGCTGAGAG	0.423			NA											12	68					0	0	0.001855	0	0
DDI1	414301	broad.mit.edu	37	11	103908255	103908255	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:103908255C>A	uc001phr.2	+	1	948	c.705C>A	c.(703-705)CCC>CCA	p.P235P	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	235					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AAGAGGCCCCCGAGAGTTTTG	0.478			NA											49	180					4.10826e-27	7.44209e-27	0.00361	1	0
NCAM1	4684	broad.mit.edu	37	11	113102898	113102898	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:113102898C>A	uc009yyq.1	+	12	1665	c.971C>A	c.(970-972)CCA>CAA	p.P324Q		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	416	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCAGATGCCCCAAAGCTACAG	0.522			NA											11	44					0.000151284	0.000161534	0.001855	1	0
RNF26	79102	broad.mit.edu	37	11	119207086	119207086	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:119207086C>T	uc001pwh.2	+	1	1850	c.1254C>T	c.(1252-1254)TGC>TGT	p.C418C		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	418	RING-type.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		ACCGCAATTGCCCGCTCTGCC	0.642			NA											33	130					0	0	0.003755	0	0
TRIM29	23650	broad.mit.edu	37	11	119996441	119996441	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:119996441C>A	uc001pwz.2	-	4	1415	c.1291G>T	c.(1291-1293)GAC>TAC	p.D431Y	TRIM29_uc001pwy.2_5'Flank|TRIM29_uc010rzi.1_Missense_Mutation_p.D170Y|TRIM29_uc010rzj.1_Missense_Mutation_p.D164Y|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	431					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CGGCTCAGGTCCGCCTTGCAC	0.562			NA											21	81					1.55795e-14	2.26924e-14	0.001882	1	0
OR8D4	338662	broad.mit.edu	37	11	123777159	123777159	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:123777159C>T	uc010saa.1	+	1	21	c.21C>T	c.(19-21)TCC>TCT	p.S7S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AAAACCATTCCACAGTGACTG	0.388			NA											27	94					0	0	0.004656	0	0
OR4D5	219875	broad.mit.edu	37	11	123811224	123811224	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:123811224C>T	uc001pzk.1	+	1	901	c.901C>T	c.(901-903)CTG>TTG	p.L301L		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CATGAAGAAGCTGTGGAGGAG	0.493			NA											31	150					0	0	0.002096	0	0
OR10S1	219873	broad.mit.edu	37	11	123848164	123848164	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:123848164G>A	uc001pzm.1	-	1	235	c.235C>T	c.(235-237)CTC>TTC	p.L79F		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGGAAGGAGAGGTGCCCCAGG	0.557			NA											15	53					0	0	0.00245	0	0
OR10G8	219869	broad.mit.edu	37	11	123900722	123900722	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:123900722C>A	uc001pzp.1	+	1	393	c.393C>A	c.(391-393)TAC>TAA	p.Y131*		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CGCTCAGGTACACCAGCATGA	0.542			NA											58	205					1.46156e-29	2.71629e-29	0.00361	1	0
PANX3	116337	broad.mit.edu	37	11	124489566	124489566	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:124489566A>G	uc001qah.2	+	4	914	c.914A>G	c.(913-915)TAT>TGT	p.Y305C		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	305	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TTATCTGTCTATGAGATGCTC	0.443			NA											40	136					0	0	0.00874	0	0
ROBO4	54538	broad.mit.edu	37	11	124754957	124754957	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:124754957C>T	uc001qbg.2	-	17	3121	c.2981G>A	c.(2980-2982)TGT>TAT	p.C994Y	ROBO4_uc010sas.1_Missense_Mutation_p.C849Y	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	994					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGGCATACGACAGTGGAGCTG	0.587			NA											34	126					0	0	0.004289	0	0
PKNOX2	63876	broad.mit.edu	37	11	125301253	125301253	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:125301253G>T	uc001qbu.2	+	13	1698	c.1384G>T	c.(1384-1386)GAC>TAC	p.D462Y	PKNOX2_uc010saz.1_Missense_Mutation_p.D433Y|PKNOX2_uc010sba.1_Missense_Mutation_p.D433Y|PKNOX2_uc010sbb.1_Missense_Mutation_p.D398Y|PKNOX2_uc001qbv.2_Missense_Mutation_p.D227Y	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	462						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		AAATGTCAGCGACCTGGGCTT	0.423			NA											15	53					6.31663e-08	7.34145e-08	0.003163	1	0
STT3A	3703	broad.mit.edu	37	11	125482978	125482978	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:125482978C>G	uc001qcd.2	+	13	1570	c.1460C>G	c.(1459-1461)TCC>TGC	p.S487C	STT3A_uc001qce.2_Missense_Mutation_p.S487C|STT3A_uc010sbg.1_Missense_Mutation_p.S395C|STT3A_uc009zbn.2_Missense_Mutation_p.S209C	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	487	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TCTTCTCCGTCCATTGTACTA	0.473			NA											60	226					0	0	0.00361	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1969334	1969334	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:1969334C>G	uc001qjp.2	-	19	2148	c.1917G>C	c.(1915-1917)ACG>ACC	p.T639T	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.T503T	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	639	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CGCTGATGTCCGTGAAGAAGT	0.502	Colon(2;101 179 21030 23310 28141)		NA											9	14					0	0	0.001368	0	0
CD163L1	283316	broad.mit.edu	37	12	7559189	7559189	+	Silent	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:7559189T>C	uc001qsy.2	-	5	1052	c.1026A>G	c.(1024-1026)AGA>AGG	p.R342R	CD163L1_uc010sge.1_Silent_p.R352R	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	342	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TTCCGGAATGTCTGCAGTCCC	0.433			NA											23	93					0	0	0.001882	0	0
SLC2A3	6515	broad.mit.edu	37	12	8075422	8075422	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:8075422C>A	uc001qtr.2	-	9	1529	c.1267G>T	c.(1267-1269)GCT>TCT	p.A423S		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	423	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		CTTACAGCAGCGGAGGGGAAG	0.483	Colon(96;424 1461 14416 20933 23688)		NA											23	63					6.44725e-10	7.9881e-10	0.002299	1	0
A2M	2	broad.mit.edu	37	12	9225296	9225296	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:9225296C>A	uc001qvk.1	-	30	4041	c.3928G>T	c.(3928-3930)GGG>TGG	p.G1310W	A2M_uc001qvj.1_Missense_Mutation_p.G352W|A2M_uc009zgk.1_Missense_Mutation_p.G1160W	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1310					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CTGTATTCCCCAGGCAGCTCT	0.517			NA											51	154					2.23044e-30	4.20475e-30	0.00361	1	0
PZP	5858	broad.mit.edu	37	12	9302192	9302192	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:9302192G>T	uc001qvl.2	-	35	4420	c.4391C>A	c.(4390-4392)TCT>TAT	p.S1464Y	PZP_uc009zgl.2_Missense_Mutation_p.S1250Y	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGCAACCACAGACTCATCTGA	0.463	Melanoma(125;1402 1695 4685 34487 38571)		NA											30	70					1.06801e-11	1.43372e-11	0.009535	1	0
MANSC1	54682	broad.mit.edu	37	12	12491436	12491436	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:12491436G>A	uc001rai.1	-	3	540	c.282C>T	c.(280-282)AAC>AAT	p.N94N	MANSC1_uc010shm.1_Silent_p.N28N|MANSC1_uc001raj.1_Silent_p.N60N|MANSC1_uc009zht.1_Silent_p.N13N	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	94	MANSC.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		ATAGGTAGCAGTTGGGTTGTC	0.393			NA											34	88					0	0	0.002836	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18499667	18499667	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:18499667G>T	uc001rdt.2	+	11	1638	c.1522G>T	c.(1522-1524)GTA>TTA	p.V508L	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.V508L|PIK3C2G_uc010sic.1_Missense_Mutation_p.V286L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	508					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TTTTCAGCCTGTAAATGTACC	0.438			NA											29	74					1.80694e-10	2.29657e-10	0.009535	1	0
PDE3A	5139	broad.mit.edu	37	12	20801732	20801733	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:20801732_20801733GG>TT	uc001reh.1	+	13	2698_2699	c.2676_2677GG>TT	c.(2674-2679)GTGGAA>GTTTAA	p.E893*		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	893	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TTGACCATGTGGAATTTAAGCA	0.401			NA											35	103					0	0	0.004672	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355423	21355423	+	Splice_Site	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:21355423A>C	uc001req.3	+	10	1240	c.1136_splice	c.e10-2	p.G379_splice		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTTTTTTTCTAGGAGTCATAA	0.269			NA											13	25					0	0	0.001368	0	0
CASC1	55259	broad.mit.edu	37	12	25261485	25261485	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:25261485G>T	uc001rgl.2	-	15	2230	c.2148C>A	c.(2146-2148)TCC>TCA	p.S716S	CASC1_uc001rgk.2_Silent_p.S722S|CASC1_uc001rgm.3_3'UTR|CASC1_uc001rgj.2_Silent_p.S676S|CASC1_uc010sje.1_Silent_p.S657S|CASC1_uc010sjf.1_3'UTR	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	716										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			GTGGAGGTTAGGAGTAGCTGA	0.418			NA											12	25					4.36969e-10	5.43968e-10	0.001855	1	0
CNTN1	1272	broad.mit.edu	37	12	41422935	41422935	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:41422935C>G	uc001rmm.1	+	23	3007	c.2894C>G	c.(2893-2895)CCA>CGA	p.P965R	CNTN1_uc001rmn.1_Missense_Mutation_p.P954R	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	965	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				ATAGAAGTCCCAATCCCCAGA	0.448			NA											70	147					0	0	0.00361	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43925996	43925996	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:43925996C>A	uc010skx.1	-	3	456	c.456G>T	c.(454-456)ACG>ACT	p.T152T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	152				T -> V (in Ref. 2; CAD56159/CAD56160).		proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TAAATGTTCCCGTCTGAAAAT	0.353			NA											24	69					5.61819e-17	8.64674e-17	0.005443	1	0
WNT1	7471	broad.mit.edu	37	12	49374219	49374219	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:49374219C>A	uc001rsu.2	+	3	569	c.371C>A	c.(370-372)ACG>AAG	p.T124K		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	124					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		TGTCGAGAAACGGCGTTTATC	0.617			NA											15	32					1.5739e-10	2.01992e-10	0.004007	1	0
MLL2	8085	broad.mit.edu	37	12	49432243	49432243	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:49432243G>A	uc001rta.3	-	34	8896	c.8896C>T	c.(8896-8898)CGG>TGG	p.R2966W		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2966	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GACGGGGGCCGGTTGACCAGC	0.602			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			52	90					0	0	0.00361	0	0
KCNH3	23416	broad.mit.edu	37	12	49949578	49949578	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:49949578G>A	uc001ruh.1	+	12	2572	c.2312G>A	c.(2311-2313)CGT>CAT	p.R771H	KCNH3_uc010smj.1_Missense_Mutation_p.R711H	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	771	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CTATCCCCACGTCGAACAGCA	0.697			NA											19	26					0	0	0.00278	0	0
FMNL3	91010	broad.mit.edu	37	12	50045837	50045837	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:50045837C>G	uc001ruv.1	-	14	1716	c.1482G>C	c.(1480-1482)CTG>CTC	p.L494L	FMNL3_uc001ruw.1_Silent_p.L443L|FMNL3_uc001rut.1_Silent_p.L60L|FMNL3_uc001ruu.1_Silent_p.L344L	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	494					actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						TGCCCTCACTCAGCTCTGCAG	0.652			NA											10	18					0	0	0.008291	0	0
ACCN2	41	broad.mit.edu	37	12	50472204	50472204	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:50472204C>A	uc001rvw.2	+	6	1067	c.838C>A	c.(838-840)CTC>ATC	p.L280I	ACCN2_uc001rvv.2_Missense_Mutation_p.L280I|ACCN2_uc009zln.2_Missense_Mutation_p.L71I|ACCN2_uc009zlo.2_Missense_Mutation_p.L280I	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	280	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	CTCCCAGCAGCTCATCTACCT	0.582			NA											55	92					1.39843e-22	2.37492e-22	0.00361	1	0
SLC4A8	9498	broad.mit.edu	37	12	51879644	51879644	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:51879644G>C	uc001rys.1	+	17	2424	c.2246G>C	c.(2245-2247)GGA>GCA	p.G749A	SLC4A8_uc001rym.2_Missense_Mutation_p.G696A|SLC4A8_uc001ryn.2_Missense_Mutation_p.G696A|SLC4A8_uc001ryo.2_Missense_Mutation_p.G696A|SLC4A8_uc010snj.1_Missense_Mutation_p.G776A|SLC4A8_uc001ryr.2_Missense_Mutation_p.G749A	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	749	Helical; (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTTTTGATTGGAGTCCCATCA	0.418			NA											47	79					0	0	0.00361	0	0
HOXC6	3223	broad.mit.edu	37	12	54423739	54423739	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:54423739A>C	uc001sev.2	+	2	813	c.701A>C	c.(700-702)AAA>ACA	p.K234T	HOXC6_uc001ses.2_Missense_Mutation_p.K152T|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	234	Glu/Lys-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAGAAGCAGAAAGAGTGACCA	0.582			NA											6	12					0	0	0.001984	0	0
SLC16A7	9194	broad.mit.edu	37	12	60098636	60098636	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:60098636G>C	uc001sqs.2	+	3	353	c.54G>C	c.(52-54)TGG>TGC	p.W18C	SLC16A7_uc001sqt.2_Missense_Mutation_p.W18C|SLC16A7_uc001squ.2_Missense_Mutation_p.W18C|SLC16A7_uc009zqi.2_5'UTR|SLC16A7_uc010ssi.1_5'UTR	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	18	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATGGAGGATGGGGTTGGATTG	0.433			NA											27	43					0	0	0.004656	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72027129	72027129	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:72027129T>C	uc001swo.2	-	13	2959	c.2600A>G	c.(2599-2601)AAG>AGG	p.K867R		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	867	Potential.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTTTGTAATCTTTGCTTCAGC	0.289			NA											10	21					0	0	0.006214	0	0
CAPS2	84698	broad.mit.edu	37	12	75678809	75678809	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:75678809C>A	uc001sxk.3	-	16	1701	c.1504G>T	c.(1504-1506)GAT>TAT	p.D502Y	CAPS2_uc001sxm.3_Missense_Mutation_p.D270Y|CAPS2_uc009zsa.2_Missense_Mutation_p.D92Y|CAPS2_uc001sxi.3_Missense_Mutation_p.D238Y|CAPS2_uc001sxj.3_Missense_Mutation_p.D413Y|CAPS2_uc001sxl.3_Missense_Mutation_p.D483Y	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	502	EF-hand 2.|2 (Potential).						calcium ion binding			ovary(2)	2						TCTCCATAATCAACCTTGCCA	0.323			NA											34	38					2.68265e-12	3.70865e-12	0.002836	1	0
PPFIA2	8499	broad.mit.edu	37	12	81676789	81676789	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:81676789C>A	uc001szo.1	-	26	3179	c.3018G>T	c.(3016-3018)CAG>CAT	p.Q1006H	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_Intron|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(3)|lung(2)|pancreas(1)	6						AATCTCCTACCTGGGCCCAGC	0.318			NA											8	17					1.58986e-06	1.77956e-06	0.008291	1	0
C12orf12	196477	broad.mit.edu	37	12	91347339	91347339	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:91347339G>A	uc001tbj.2	-	1	1615	c.1181C>T	c.(1180-1182)CCA>CTA	p.P394L		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	394										central_nervous_system(1)|pancreas(1)	2						GGATTCCTGTGGCACTTTGGG	0.408			NA											58	68					0	0	0.00361	0	0
CKAP4	10970	broad.mit.edu	37	12	106633401	106633401	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:106633401G>C	uc001tlk.2	-	2	1294	c.1210C>G	c.(1210-1212)CAA>GAA	p.Q404E		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	404	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						TGACTCTTTTGCTGGAGTGCC	0.632			NA											53	83					0	0	0.00361	0	0
BTBD11	121551	broad.mit.edu	37	12	108042981	108042981	+	Splice_Site	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:108042981A>T	uc001tmk.1	+	15	3444	c.2923_splice	c.e15-2	p.L975_splice	BTBD11_uc001tmj.2_Splice_Site_p.L975_splice|BTBD11_uc001tml.1_Splice_Site_p.L512_splice|BTBD11_uc001tmm.1_Splice_Site_p.L54_splice	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a							integral to membrane	DNA binding			skin(2)|ovary(1)	3						GTTTTCTTCCAGCTGGTTATG	0.443			NA											57	59					0	0	0.00361	0	0
TRPV4	59341	broad.mit.edu	37	12	110232179	110232179	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:110232179C>A	uc001tpj.1	-	7	1541	c.1446G>T	c.(1444-1446)ATG>ATT	p.M482I	TRPV4_uc001tpg.1_Missense_Mutation_p.M448I|TRPV4_uc001tph.1_Missense_Mutation_p.M435I|TRPV4_uc001tpi.1_Missense_Mutation_p.M375I|TRPV4_uc001tpk.1_Missense_Mutation_p.M482I|TRPV4_uc001tpl.1_Missense_Mutation_p.M422I	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	482	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGAAGATGACCATGGCACACA	0.632			NA											47	68					5.48756e-27	9.89519e-27	0.002852	1	0
ALDH2	217	broad.mit.edu	37	12	112235926	112235926	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:112235926G>T	uc001tst.2	+	10	1569	c.1128G>T	c.(1126-1128)ACG>ACT	p.T376T	ALDH2_uc010syi.1_Silent_p.T329T|ALDH2_uc009zvy.2_Silent_p.T300T	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	376					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity			skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	ACATCAACACGGGGAAGCAAG	0.542			NA	T	HMGA2	leiomyoma								24	51					5.45024e-15	8.07291e-15	0.00333	1	0
DTX1	1840	broad.mit.edu	37	12	113515246	113515246	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:113515246C>A	uc001tuk.1	+	2	613	c.277C>A	c.(277-279)CGG>AGG	p.R93R		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	93	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GCGGCCCGTGCGGCGCAACTT	0.682			NA											24	37					4.26978e-12	5.81103e-12	0.00333	1	0
KDM2B	84678	broad.mit.edu	37	12	121882033	121882033	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:121882033C>A	uc001uat.2	-	16	2337	c.2233G>T	c.(2233-2235)GGC>TGC	p.G745C	KDM2B_uc001uaq.2_Missense_Mutation_p.G185C|KDM2B_uc010szy.1_Missense_Mutation_p.G185C|KDM2B_uc001uar.2_Missense_Mutation_p.G336C|KDM2B_uc001uas.2_Missense_Mutation_p.G714C|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_5'UTR|KDM2B_uc010szx.1_5'UTR|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	745					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGCAGGGAGCCGGGCAGGTTG	0.572			NA									OREG0022201	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	77					3.30712e-30	6.21959e-30	0.00361	1	0
ABCB9	23457	broad.mit.edu	37	12	123434340	123434340	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:123434340C>A	uc001udm.3	-	4	1152	c.842G>T	c.(841-843)CGC>CTC	p.R281L	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.R281L|ABCB9_uc010taj.1_Missense_Mutation_p.R281L|ABCB9_uc001udp.2_Missense_Mutation_p.R281L|ABCB9_uc001udq.2_Missense_Mutation_p.R63L|ABCB9_uc001udr.2_Missense_Mutation_p.R281L	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	281	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CCAACCTGTGCGGTTCTCATC	0.567	Ovarian(49;786 1333 9175 38236)		NA											53	78					2.13883e-14	3.10386e-14	0.00361	1	0
DNAH10	196385	broad.mit.edu	37	12	124364246	124364246	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:124364246G>A	uc001uft.3	+	49	8203	c.8178G>A	c.(8176-8178)AGG>AGA	p.R2726R		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2726					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGTGATGAGGGATCCCATAT	0.493			NA											109	184					0	0	0.00361	0	0
TMEM132D	121256	broad.mit.edu	37	12	129563130	129563130	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr12:129563130C>A	uc009zyl.1	-	8	2392	c.2064G>T	c.(2062-2064)AGG>AGT	p.R688S	TMEM132D_uc001uia.2_Missense_Mutation_p.R226S	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	688	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CAAAGATGGCCCTGTTGCTTC	0.582			NA											56	82					4.17463e-26	7.45943e-26	0.00361	1	0
FAM123A	219287	broad.mit.edu	37	13	25744474	25744474	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:25744474C>A	uc001uqb.2	-	1	1384	c.1284G>T	c.(1282-1284)CCG>CCT	p.P428P	FAM123A_uc001uqa.2_Silent_p.P309P|FAM123A_uc001uqc.2_Silent_p.P309P	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	428										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CCACCTCGTCCGGGCTGGCCA	0.652			NA											12	46					2.27111e-07	2.59367e-07	0.001368	1	0
ATP8A2	51761	broad.mit.edu	37	13	26043257	26043257	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:26043257C>A	uc001uqk.2	+	2	361	c.219C>A	c.(217-219)ATC>ATA	p.I73I	ATP8A2_uc010tdi.1_Silent_p.I33I|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Silent_p.I33I	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	33	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACAACCAGATCAGGTAGGAGA	0.667			NA											9	27					2.74318e-10	3.4586e-10	0.006214	1	0
RCBTB2	1102	broad.mit.edu	37	13	49076887	49076887	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:49076887C>A	uc001vch.2	-	11	1461	c.1090G>T	c.(1090-1092)GCC>TCC	p.A364S	RCBTB2_uc010tgg.1_Missense_Mutation_p.A369S|RCBTB2_uc001vci.2_Missense_Mutation_p.A340S|RCBTB2_uc010tgh.1_Missense_Mutation_p.A90S|RCBTB2_uc001vcj.2_Missense_Mutation_p.A316S|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_3'UTR	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	364	RCC1 6.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACGTGACGGCGGGCGTGGCA	0.592			NA											35	53					2.42023e-17	3.76906e-17	0.003271	1	0
LOC220429	220429	broad.mit.edu	37	13	50466697	50466697	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:50466697A>G	uc001vdk.2	+	1	2153	c.1971A>G	c.(1969-1971)GAA>GAG	p.E657E		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						TGCATTCAGAAATGGAATTCA	0.403			NA											54	118					0	0	0.00361	0	0
VPS36	51028	broad.mit.edu	37	13	53024666	53024666	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:53024666G>A	uc001vgs.2	-	1	98	c.64C>T	c.(64-66)CGC>TGC	p.R22C	VPS36_uc001vgq.2_5'Flank	NM_016075	NP_057159	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36	22	GLUE N-terminal.				cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			skin(1)	1		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		CGCACCCCGCGCTGCTGGATC	0.662			NA											19	17					0	0	0.001882	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217055	53217055	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:53217055G>T	uc001vgx.1	+	7	1501	c.428G>T	c.(427-429)GGC>GTC	p.G143V	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.G143V|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.G143V	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	143	Globular B domain.|RRM 2.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						CGAGGCAGTGGCAAGAAAAGG	0.408			NA											17	57					1.99824e-07	2.29201e-07	0.00499	1	0
PCDH20	64881	broad.mit.edu	37	13	61987564	61987564	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:61987564G>T	uc001vid.3	-	2	1032	c.668C>A	c.(667-669)CCT>CAT	p.P223H	PCDH20_uc010thj.1_Missense_Mutation_p.P223H	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	196	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTGTTTACAGGTGCATTTTC	0.517			NA											58	148					1.54043e-34	2.97515e-34	0.00361	1	0
SLITRK5	26050	broad.mit.edu	37	13	88329238	88329238	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:88329238G>T	uc001vln.2	+	2	1814	c.1595G>T	c.(1594-1596)AGG>ATG	p.R532M	SLITRK5_uc010tic.1_Missense_Mutation_p.R291M	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	532	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACCCTCCTCAGGCTAAACCTG	0.527			NA											48	74					6.21074e-16	9.35768e-16	0.002852	1	0
DOCK9	23348	broad.mit.edu	37	13	99520213	99520213	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:99520213T>C	uc001vnt.2	-	29	3201	c.3146A>G	c.(3145-3147)TAC>TGC	p.Y1049C	DOCK9_uc001vnw.2_Missense_Mutation_p.Y1048C|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.Y1049C|DOCK9_uc010tis.1_Missense_Mutation_p.Y1048C|DOCK9_uc010tit.1_Missense_Mutation_p.Y1049C|DOCK9_uc010tiq.1_Missense_Mutation_p.Y13C|DOCK9_uc010afu.1_Missense_Mutation_p.Y895C	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1049					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACAGCTAATGTAGTTGTTGAT	0.428			NA											13	14					0	0	0.001855	0	0
FGF14	2259	broad.mit.edu	37	13	102378993	102378993	+	Silent	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:102378993T>G	uc001vpe.2	-	4	576	c.576A>C	c.(574-576)CCA>CCC	p.P192P	FGF14_uc001vpf.2_Silent_p.P197P	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	192					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATGAGCTGCTGGTTTGGTTT	0.363			NA											27	44					0	0	0.003954	0	0
COL4A1	1282	broad.mit.edu	37	13	110863998	110863998	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr13:110863998A>T	uc001vqw.3	-	8	586	c.464T>A	c.(463-465)ATG>AAG	p.M155K	COL4A1_uc010agl.2_Missense_Mutation_p.M155K	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	155					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			ATGTACCTTCATCCCTGGTAA	0.313			NA											14	36					0	0	0.00245	0	0
OR4K14	122740	broad.mit.edu	37	14	20483031	20483031	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:20483031T>C	uc010tky.1	-	1	322	c.322A>G	c.(322-324)ACT>GCT	p.T108A		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GCCCCACCAGTAAAGTGCAAG	0.463			NA											17	75					0	0	0.006122	0	0
OR6S1	341799	broad.mit.edu	37	14	21108972	21108972	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:21108972A>G	uc001vxv.1	-	1	879	c.879T>C	c.(877-879)TAT>TAC	p.Y293Y		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	293	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TACGTAAGGCATAGATGAATG	0.438			NA											60	188					0	0	0.00361	0	0
MYH6	4624	broad.mit.edu	37	14	23866764	23866764	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:23866764C>A	uc001wjv.2	-	16	2017	c.1950G>T	c.(1948-1950)TCG>TCT	p.S650S		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	650	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGTGGAGAGCCGACACCGTCT	0.507			NA											39	142					2.58029e-29	4.78415e-29	0.009718	1	0
MYH7	4625	broad.mit.edu	37	14	23886822	23886823	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:23886822_23886823CC>AA	uc001wjx.2	-	31	4348_4349	c.4242_4243GG>TT	c.(4240-4245)CTGGAG>CTTTAG	p.E1415*		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1415	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGGTCTTCTCCAGCGAGGAGC	0.609			NA											26	109					0	0	0.004672	0	0
ARHGAP5	394	broad.mit.edu	37	14	32560197	32560198	+	Missense_Mutation	DNP	CG	CG	TC			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:32560197_32560198CG>TC	uc001wrl.2	+	2	561_562	c.322_323CG>TC	c.(322-324)CGG>TCG	p.R108S	ARHGAP5_uc001wrm.2_Missense_Mutation_p.R108S|ARHGAP5_uc001wrn.2_Missense_Mutation_p.R108S|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	108					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTTGCCTCATCGGAGTACGAAT	0.381	NSCLC(9;77 350 3443 29227 41353)		NA											37	131					0	0	0.004672	0	0
AKAP6	9472	broad.mit.edu	37	14	33205041	33205041	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:33205041G>T	uc001wrq.2	+	11	3495	c.3325G>T	c.(3325-3327)GAA>TAA	p.E1109*		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1109	Spectrin 2.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCTGAGACAAGAAAAGGAAGG	0.373	Melanoma(49;821 1200 7288 13647 42351)		NA											18	82					1.99824e-07	2.29201e-07	0.00499	1	0
SEC23A	10484	broad.mit.edu	37	14	39556195	39556195	+	Silent	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:39556195A>C	uc001wup.1	-	6	844	c.621T>G	c.(619-621)TCT>TCG	p.S207S	SEC23A_uc010tqa.1_Silent_p.S69S|SEC23A_uc010tqb.1_Silent_p.S178S|SEC23A_uc010tqc.1_Silent_p.S69S	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	207					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GTGGTACTTTAGAGAGCCCCA	0.303			NA											32	70					0	0	0.002836	0	0
GPR135	64582	broad.mit.edu	37	14	59930621	59930621	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:59930621T>A	uc010apj.2	-	1	1439	c.1324A>T	c.(1324-1326)AAC>TAC	p.N442Y	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	442	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)		GACATCCTGTTGCAGGCCCCC	0.632			NA											10	24					0	0	0.001855	0	0
JKAMP	51528	broad.mit.edu	37	14	59970757	59970757	+	Silent	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:59970757A>T	uc001xei.3	+	7	1447	c.945A>T	c.(943-945)TCA>TCT	p.S315S	JKAMP_uc001xef.3_Silent_p.S301S|JKAMP_uc001xeh.3_Silent_p.S295S|JKAMP_uc001xeg.3_Silent_p.S309S|JKAMP_uc010try.1_Silent_p.S238S|JKAMP_uc001xej.3_Silent_p.S238S	NM_001098625	NP_001092095	Q9P055	JKAMP_HUMAN	JNK1-associated membrane protein isoform 2	316	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)	1						CCGAACCTTCAAGGATACTCT	0.398			NA											7	55					0	0	0.001984	0	0
SYNE2	23224	broad.mit.edu	37	14	64483301	64483301	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:64483301G>T	uc001xgm.2	+	33	5069	c.4839G>T	c.(4837-4839)GAG>GAT	p.E1613D	SYNE2_uc001xgl.2_Missense_Mutation_p.E1613D	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1613	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTTTTGAAGAGCCCCCTTTTG	0.284			NA											8	25					5.18039e-06	5.7495e-06	0.00308	1	0
SPTB	6710	broad.mit.edu	37	14	65253520	65253520	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:65253520C>A	uc001xht.2	-	15	3217	c.3163G>T	c.(3163-3165)GAC>TAC	p.D1055Y	SPTB_uc001xhr.2_Missense_Mutation_p.D1055Y|SPTB_uc001xhs.2_Missense_Mutation_p.D1055Y|SPTB_uc001xhu.2_Missense_Mutation_p.D1055Y	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1055	Spectrin 8.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCCAGCAAGTCCTCCTGGCCC	0.607			NA											23	124					1.22574e-08	1.46124e-08	0.002299	1	0
SLC8A3	6547	broad.mit.edu	37	14	70515594	70515594	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:70515594C>G	uc001xly.2	-	7	3051	c.2297G>C	c.(2296-2298)GGC>GCC	p.G766A	SLC8A3_uc001xlu.2_Missense_Mutation_p.G123A|SLC8A3_uc001xlv.2_Missense_Mutation_p.G137A|SLC8A3_uc001xlw.2_Missense_Mutation_p.G763A|SLC8A3_uc001xlx.2_Missense_Mutation_p.G764A|SLC8A3_uc001xlz.2_Missense_Mutation_p.G760A|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.G123A	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	766	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGTGAGCATGCCAATGATGAG	0.572			NA											7	35					0	0	0.00308	0	0
LTBP2	4053	broad.mit.edu	37	14	74969481	74969481	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:74969481G>T	uc001xqa.2	-	34	5432	c.5045C>A	c.(5044-5046)CCC>CAC	p.P1682H		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1682					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGTGTCCTCGGGGCCCAGGTA	0.632			NA											35	140					1.45844e-13	2.08575e-13	0.002836	1	0
KCNK10	54207	broad.mit.edu	37	14	88658607	88658607	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:88658607C>A	uc001xwo.2	-	5	1271	c.814G>T	c.(814-816)GTC>TTC	p.V272F	KCNK10_uc001xwm.2_Missense_Mutation_p.V277F|KCNK10_uc001xwn.2_Missense_Mutation_p.V277F	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	272					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GTCAGAGTGACCACCACAAAG	0.542			NA											30	133					1.74807e-11	2.31899e-11	0.002096	1	0
SERPINA4	5267	broad.mit.edu	37	14	95030031	95030031	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:95030031C>A	uc001ydk.2	+	2	278	c.212C>A	c.(211-213)CCG>CAG	p.P71Q	SERPINA4_uc010avd.2_Missense_Mutation_p.P108Q|SERPINA4_uc001ydl.2_Missense_Mutation_p.P71Q	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	71					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TCGGAGACCCCGGGGAAGAAC	0.607			NA											52	102					9.57592e-29	1.75893e-28	0.00361	1	0
HHIPL1	84439	broad.mit.edu	37	14	100118631	100118631	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:100118631G>T	uc010avs.2	+	2	391	c.326G>T	c.(325-327)GGG>GTG	p.G109V	HHIPL1_uc001ygl.1_Missense_Mutation_p.G109V	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	109					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				ACGGTGCCCGGGCTCTGCCAG	0.612			NA											31	81					3.80469e-20	6.20724e-20	0.009535	1	0
C15orf2	23742	broad.mit.edu	37	15	24922547	24922547	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:24922547C>A	uc001ywo.2	+	1	2007	c.1533C>A	c.(1531-1533)GTC>GTA	p.V511V		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	511	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AGCCTCCCGTCACAAGGGAGT	0.537			NA											113	284					1.30845e-55	2.69206e-55	0.00361	1	0
RYR3	6263	broad.mit.edu	37	15	33872331	33872331	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:33872331C>G	uc001zhi.2	+	13	1493	c.1423C>G	c.(1423-1425)CTT>GTT	p.L475V	RYR3_uc010bar.2_Missense_Mutation_p.L475V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	475	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGACAAAATCTTTTCAAGGA	0.443			NA											14	15					0	0	0.001855	0	0
SEMA6D	80031	broad.mit.edu	37	15	48057248	48057248	+	Missense_Mutation	SNP	T	T	G	rs147987261		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:48057248T>G	uc010bek.2	+	13	1782	c.1422T>G	c.(1420-1422)CAT>CAG	p.H474Q	SEMA6D_uc001zvw.2_Missense_Mutation_p.H474Q|SEMA6D_uc001zvx.1_Missense_Mutation_p.H474Q|SEMA6D_uc001zvy.2_Missense_Mutation_p.H474Q|SEMA6D_uc001zvz.2_Missense_Mutation_p.H474Q|SEMA6D_uc001zwa.2_Missense_Mutation_p.H474Q|SEMA6D_uc001zwb.2_Missense_Mutation_p.H474Q|SEMA6D_uc001zwc.2_Missense_Mutation_p.H474Q	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	474	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CCTACAACCATGCAAAGTAGG	0.423			NA											17	56					0	0	0.006122	0	0
UNC13C	440279	broad.mit.edu	37	15	54586108	54586108	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:54586108C>A	uc002ack.2	+	9	3834	c.3834C>A	c.(3832-3834)TCC>TCA	p.S1278S	UNC13C_uc002acl.2_Silent_p.S108S	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1278	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTCATAACTCCACAGATCGAA	0.323			NA											27	46					4.72057e-08	5.50268e-08	0.003954	1	0
VPS13C	54832	broad.mit.edu	37	15	62304305	62304305	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:62304305C>A	uc002agz.2	-	12	957	c.883_splice	c.e12+1	p.I295_splice	VPS13C_uc002aha.2_Splice_Site_p.I252_splice|VPS13C_uc002ahb.1_Splice_Site_p.I295_splice|VPS13C_uc002ahc.1_Splice_Site_p.I252_splice	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2						CTATTACTTACTGTATTGATA	0.244			NA											7	29					8.12818e-05	8.70246e-05	0.001984	1	0
HERC1	8925	broad.mit.edu	37	15	63987027	63987027	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:63987027G>C	uc002amp.2	-	28	5336	c.5188C>G	c.(5188-5190)CAA>GAA	p.Q1730E		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1730					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GACAACTGTTGATAAATTTTA	0.378			NA											20	51					0	0	0.010504	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729153	66729153	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:66729153T>A	uc010bhq.2	+	3	836	c.361T>A	c.(361-363)TGC>AGC	p.C121S	MAP2K1_uc010ujp.1_Missense_Mutation_p.C99S	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	121	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TCTGCATGAGTGCAACTCTCC	0.502			NA							Cardiofaciocutaneous_syndrome				37	68					0	0	0.003755	0	0
LINGO1	84894	broad.mit.edu	37	15	77907260	77907260	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:77907260G>T	uc002bct.1	-	2	1041	c.989C>A	c.(988-990)GCC>GAC	p.A330D	LINGO1_uc002bcu.1_Missense_Mutation_p.A324D	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	330	Extracellular (Potential).|LRR 10.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GCCGCGGAAGGCATAGGGCTC	0.617			NA											11	17					1.08611e-07	1.25308e-07	0.000978	1	0
MESDC1	59274	broad.mit.edu	37	15	81295579	81295579	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:81295579A>G	uc002bfz.2	+	1	2285	c.967A>G	c.(967-969)AGG>GGG	p.R323G		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	323											0						GTCGGACCACAGGGAGAGGCT	0.662			NA											4	11					0	0	0.001168	0	0
IL16	3603	broad.mit.edu	37	15	81585042	81585042	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:81585042G>T	uc002bgh.3	+	12	1942	c.1566G>T	c.(1564-1566)GGG>GGT	p.G522G	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Silent_p.G522G|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.G564G|IL16_uc002bgg.2_Silent_p.G522G|IL16_uc002bgi.1_5'UTR|IL16_uc002bgj.2_Silent_p.G16G|IL16_uc002bgk.2_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	522					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GGTCCCCAGGGGGAAGTCCTG	0.607			NA											22	50					2.32416e-17	3.6338e-17	0.002299	1	0
AP3B2	8120	broad.mit.edu	37	15	83349376	83349376	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:83349376G>T	uc010uoh.1	-	8	1080	c.903C>A	c.(901-903)GAC>GAA	p.D301E	AP3B2_uc010uoi.1_Missense_Mutation_p.D301E|AP3B2_uc010uoj.1_Missense_Mutation_p.D269E|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	301					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCAGCCGGTGGTCGGGGTCCA	0.706			NA											6	18					0.00198382	0.00206506	0.001984	1	0
AKAP13	11214	broad.mit.edu	37	15	86266326	86266326	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:86266326C>A	uc002blv.1	+	26	6690	c.6520C>A	c.(6520-6522)CTA>ATA	p.L2174I	AKAP13_uc002blu.1_Missense_Mutation_p.L2178I|AKAP13_uc010bnf.1_Missense_Mutation_p.L795I|AKAP13_uc002blw.1_Missense_Mutation_p.L639I|AKAP13_uc002blx.1_Missense_Mutation_p.L419I	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2174	Interaction with ESR1.|DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCAGGAAGATCTAGCACAGTC	0.418	Melanoma(94;603 1453 3280 32295 32951)		NA											19	48					2.94398e-08	3.44704e-08	0.007413	1	0
AGBL1	123624	broad.mit.edu	37	15	86702201	86702201	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:86702201G>T	uc002blz.1	+	4	374	c.294G>T	c.(292-294)ATG>ATT	p.M98I		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	98					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATGGAGCCATGGAACTGCTTT	0.443			NA											38	82					4.4882e-36	8.77594e-36	0.009718	1	0
ACAN	176	broad.mit.edu	37	15	89400186	89400186	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:89400186T>C	uc010upo.1	+	12	4744	c.4370T>C	c.(4369-4371)CTA>CCA	p.L1457P	ACAN_uc010upp.1_Missense_Mutation_p.L1457P|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1457					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGAGAAGTTCTAGAGACTTCT	0.517			NA											84	148					0	0	0.00361	0	0
C15orf42	90381	broad.mit.edu	37	15	90138748	90138748	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:90138748G>T	uc002boe.2	+	7	1806	c.1806G>T	c.(1804-1806)GTG>GTT	p.V602V		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	602					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTCCGGATGTGGCTGGGGAGA	0.443			NA											20	59					1.01871e-10	1.31168e-10	0.008871	1	0
ADAMTS17	170691	broad.mit.edu	37	15	100672318	100672318	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:100672318G>T	uc002bvv.1	-	12	1694	c.1615C>A	c.(1615-1617)CCG>ACG	p.P539T	ADAMTS17_uc002bvx.1_Missense_Mutation_p.P296T	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	539	Disintegrin.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		ACATGCTCCGGGATGGGCGTC	0.672			NA									OREG0023513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	30					0.00621372	0.00639218	0.006214	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											3	14					0	0	0.009096	0	0
WDR90	197335	broad.mit.edu	37	16	715997	715997	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:715997G>A	uc002cii.1	+	36	4536	c.4482G>A	c.(4480-4482)GAG>GAA	p.E1494E	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Silent_p.E109E|WDR90_uc010uul.1_Silent_p.E93E|WDR90_uc002cio.1_Silent_p.E93E|WDR90_uc010bqx.1_Silent_p.E93E|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1494	WD 18.									ovary(1)	1		Hepatocellular(780;0.0218)				GCCGCCCTGAGCAGCAGCGGC	0.687			NA											14	33					0	0	0.010504	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261227	1261227	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:1261227G>T	uc002cks.2	+	22	4531	c.4283G>T	c.(4282-4284)AGG>ATG	p.R1428M	CACNA1H_uc002ckt.2_Missense_Mutation_p.R1428M|CACNA1H_uc002cku.2_Missense_Mutation_p.R134M|CACNA1H_uc010brj.2_Missense_Mutation_p.R134M|CACNA1H_uc002ckv.2_Missense_Mutation_p.R134M	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1428	Cytoplasmic (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCATCACTCAGGCCCATTGGG	0.597			NA											86	73					1.26005e-42	2.51373e-42	0.00361	1	0
FLYWCH2	114984	broad.mit.edu	37	16	2946481	2946482	+	Missense_Mutation	DNP	GG	GG	TT	rs145971095		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:2946481_2946482GG>TT	uc002csa.2	+	3	402_403	c.31_32GG>TT	c.(31-33)GGT>TTT	p.G11F	FLYWCH2_uc010uwj.1_Missense_Mutation_p.G11F|FLYWCH2_uc010uwk.1_Missense_Mutation_p.G11F	NM_138439	NP_612448	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	11											0						CGAGCAGGAGGGTGAGAGTGTG	0.658			NA											27	61					0	0	0.004672	0	0
NLRC3	197358	broad.mit.edu	37	16	3613223	3613223	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:3613223T>A	uc010btn.2	-	5	2126	c.1715A>T	c.(1714-1716)CAT>CTT	p.H572L		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	572					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CTGCAGCTCATGCAGGCAGTG	0.716			NA											3	9					0	0	0.004672	0	0
ADCY9	115	broad.mit.edu	37	16	4164474	4164474	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:4164474C>T	uc002cvx.2	-	2	1509	c.970G>A	c.(970-972)GAA>AAA	p.E324K		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	324	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TTTTCCACTTCCAGGTCCTTC	0.522			NA											55	163					0	0	0.00361	0	0
MYH11	4629	broad.mit.edu	37	16	15829246	15829246	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:15829246G>T	uc002ddy.2	-	26	3590	c.3483C>A	c.(3481-3483)AGC>AGA	p.S1161R	MYH11_uc002ddv.2_Missense_Mutation_p.S1168R|MYH11_uc002ddw.2_Missense_Mutation_p.S1161R|MYH11_uc002ddx.2_Missense_Mutation_p.S1168R|MYH11_uc010bvg.2_Missense_Mutation_p.S993R	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1161	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAGTGGCTGTGCTGTCCAGTG	0.602			NA	T	CBFB	AML								24	82					2.08457e-15	3.09932e-15	0.002096	1	0
ANKS4B	257629	broad.mit.edu	37	16	21261202	21261202	+	Silent	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:21261202T>A	uc010bwp.1	+	2	358	c.315T>A	c.(313-315)GCT>GCA	p.A105A	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	105	ANK 3.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		TGGATGCTGCTGCCAGCAGGG	0.542			NA											26	71					0	0	0.005443	0	0
TNRC6A	27327	broad.mit.edu	37	16	24817548	24817548	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:24817548A>G	uc002dmm.2	+	16	4387	c.4273A>G	c.(4273-4275)AGG>GGG	p.R1425G	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1172G|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1123G|TNRC6A_uc002dmo.2_Missense_Mutation_p.R1064G|TNRC6A_uc002dmp.2_Missense_Mutation_p.R26G|TNRC6A_uc002dmq.2_Missense_Mutation_p.R92G	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1425					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GCAGCAGCAAAGGGCGCAGAG	0.507			NA											25	94					0	0	0.005443	0	0
IL27	246778	broad.mit.edu	37	16	28515060	28515060	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:28515060G>T	uc002dqc.2	-	3	282	c.259C>A	c.(259-261)CTC>ATC	p.L87I	uc010vct.1_Intron	NM_145659	NP_663634	Q8NEV9	IL27A_HUMAN	interleukin 27 precursor	87					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding				0						ACATCAGGGAGCTGCTCTCCC	0.647			NA											17	59					1.33834e-09	1.64269e-09	0.007413	1	0
ATP2A1	487	broad.mit.edu	37	16	28906166	28906166	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:28906166C>A	uc002dro.1	+	12	1495	c.1311C>A	c.(1309-1311)GTC>GTA	p.V437V	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.V437V|ATP2A1_uc002drp.1_Silent_p.V312V	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	437	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATGAGAAGGTCGGCGAGGCCA	0.572			NA											13	120					5.50884e-06	6.07978e-06	0.001368	1	0
ITGAM	3684	broad.mit.edu	37	16	31309152	31309152	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:31309152G>T	uc002ebq.2	+	14	1682	c.1584G>T	c.(1582-1584)GGG>GGT	p.G528G	ITGAM_uc002ebr.2_Silent_p.G529G|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	528	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CAGTGCTGGGGGACGTAAATG	0.607			NA											32	118					1.61788e-16	2.45171e-16	0.002445	1	0
ABCC11	85320	broad.mit.edu	37	16	48218375	48218375	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:48218375G>T	uc002eff.1	-	22	3584	c.3234C>A	c.(3232-3234)GTC>GTA	p.V1078V	ABCC11_uc002efg.1_Silent_p.V1078V|ABCC11_uc002efh.1_Silent_p.V1078V|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1078	Cytoplasmic (Potential).|ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGACAGCCATGACTTTAAAGG	0.562			NA							Cerumen_Type				62	94					3.94896e-32	7.51638e-32	0.00361	1	0
ZNF423	23090	broad.mit.edu	37	16	49559353	49559353	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:49559353C>A	uc002efs.2	-	7	3928	c.3630G>T	c.(3628-3630)CCG>CCT	p.P1210P	ZNF423_uc010vgn.1_Silent_p.P1093P	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1210	C2H2-type 28.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGAGCTTGGCCGGGGAGTCGA	0.572			NA											33	145					5.90632e-09	7.12739e-09	0.002445	1	0
NOD2	64127	broad.mit.edu	37	16	50744734	50744734	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:50744734C>A	uc002egm.1	+	4	1017	c.912C>A	c.(910-912)GGC>GGA	p.G304G	NOD2_uc010cbk.1_Silent_p.G277G|NOD2_uc002egl.1_Silent_p.G82G|NOD2_uc010cbl.1_Silent_p.G82G|NOD2_uc010cbm.1_Silent_p.G82G|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	304	NACHT.|ATP (Potential).				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CGGGCAGTGGCAAGAGCACGC	0.627			NA											11	51					1.61879e-10	2.07416e-10	0.001368	1	0
NOD2	64127	broad.mit.edu	37	16	50745614	50745614	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:50745614C>A	uc002egm.1	+	4	1897	c.1792C>A	c.(1792-1794)CCC>ACC	p.P598T	NOD2_uc010cbk.1_Missense_Mutation_p.P571T|NOD2_uc002egl.1_Missense_Mutation_p.P376T|NOD2_uc010cbl.1_Missense_Mutation_p.P376T|NOD2_uc010cbm.1_Missense_Mutation_p.P376T|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	598	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GAGTACGGCGCCCCTGGAATT	0.567			NA											11	65					1.08611e-07	1.25308e-07	0.000978	1	0
CYLD	1540	broad.mit.edu	37	16	50788335	50788335	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:50788335G>T	uc002egp.1	+	6	1328	c.913G>T	c.(913-915)GCT>TCT	p.A305S	CYLD_uc002egn.1_Nonsense_Mutation_p.E305*|CYLD_uc002ego.2_Nonsense_Mutation_p.E305*|CYLD_uc010cbs.1_Nonsense_Mutation_p.E305*|CYLD_uc002egq.1_Nonsense_Mutation_p.E305*|CYLD_uc002egr.1_Nonsense_Mutation_p.E305*|CYLD_uc002egs.1_Nonsense_Mutation_p.E305*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	305	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TATCATCCCAGGTATGTTTTC	0.254			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				31	44					3.99451e-17	6.18403e-17	0.009535	1	0
SALL1	6299	broad.mit.edu	37	16	51173730	51173730	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:51173730G>T	uc010vgs.1	-	2	2434	c.2403C>A	c.(2401-2403)AGC>AGA	p.S801R	SALL1_uc010vgr.1_Missense_Mutation_p.S704R|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	801					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACTCAGAGTAGCTGTCGGGGA	0.512	GBM(103;1352 1446 1855 4775 8890)		NA											118	196					8.58103e-55	1.7609e-54	0.00361	1	0
CHD9	80205	broad.mit.edu	37	16	53342725	53342725	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:53342725A>G	uc002ehb.2	+	33	7345	c.7181A>G	c.(7180-7182)GAG>GGG	p.E2394G	CHD9_uc002egy.2_Missense_Mutation_p.E2378G|CHD9_uc002ehc.2_Missense_Mutation_p.E2379G|CHD9_uc002ehf.2_Missense_Mutation_p.E1492G|CHD9_uc010cbw.2_Missense_Mutation_p.E460G|CHD9_uc002ehg.1_Missense_Mutation_p.E401G	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2394	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AGTGCATCAGAGACCAGCCTC	0.438			NA											9	27					0	0	0.006214	0	0
CES7	221223	broad.mit.edu	37	16	55880525	55880525	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:55880525G>T	uc002eip.2	-	13	1715	c.1566C>A	c.(1564-1566)GAC>GAA	p.D522E	CES7_uc002eio.2_Missense_Mutation_p.D472E|CES7_uc002eiq.2_Missense_Mutation_p.D283E|CES7_uc002eir.2_Missense_Mutation_p.D416E	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	522						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TCATGTTCAAGTCCAGCTGGA	0.537			NA											238	454					3.0631e-104	6.36866e-104	0.00361	1	0
BBS2	583	broad.mit.edu	37	16	56536304	56536304	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:56536304C>A	uc002ejd.2	-	9	1239	c.1005G>T	c.(1003-1005)CAG>CAT	p.Q335H	BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	335					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						GGATCAGGTCCTGCTCTGCAC	0.522			NA							Bardet-Biedl_syndrome				56	224					3.19069e-20	5.22715e-20	0.00361	1	0
SLC12A3	6559	broad.mit.edu	37	16	56901119	56901119	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:56901119G>A	uc010ccm.2	+	2	449	c.420G>A	c.(418-420)AAG>AAA	p.K140K	SLC12A3_uc002ekd.3_Silent_p.K140K|SLC12A3_uc010ccn.2_Silent_p.K139K	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	140	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCTGGGTCAAGGGGGTGATGG	0.662			NA											6	32					0	0	0.001168	0	0
CDH8	1006	broad.mit.edu	37	16	61851501	61851501	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:61851501C>A	uc002eog.1	-	7	1411	c.1159G>T	c.(1159-1161)GAG>TAG	p.E387*	CDH8_uc002eoh.2_Nonsense_Mutation_p.E156*	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	387	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ACCGGAGGCTCATCAGCATCT	0.498			NA											47	102					1.89013e-27	3.43977e-27	0.00361	1	0
TRADD	8717	broad.mit.edu	37	16	67190465	67190465	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:67190465C>A	uc002eri.1	-	2	179	c.99G>T	c.(97-99)GCG>GCT	p.A33A	TRADD_uc002erh.1_5'Flank|TRADD_uc010vjb.1_Silent_p.A33A	NM_003789	NP_003780	Q15628	TRADD_HUMAN	TNFRSF1A-associated via death domain	33					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			lung(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GCTGGGGGTGCGCGTAGGCAT	0.632			NA									OREG0023872	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	177					3.77016e-25	6.64627e-25	0.003214	1	0
DPEP3	64180	broad.mit.edu	37	16	68010643	68010643	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:68010643C>T	uc002evc.3	-	8	1223	c.1129G>A	c.(1129-1131)GAG>AAG	p.E377K	DPEP3_uc010cex.2_Missense_Mutation_p.E376K	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	352					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		CCGATGAACTCAGATCCAATG	0.562			NA											7	47					0	0	0.00308	0	0
TAT	6898	broad.mit.edu	37	16	71604708	71604708	+	Silent	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:71604708T>A	uc002fap.2	-	8	885	c.786A>T	c.(784-786)CCA>CCT	p.P262P		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	262					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GGGTGGCCAGTGGTTCATATT	0.552	Melanoma(198;542 2142 10292 21661 50033)|Esophageal Squamous(48;487 1013 5572 44395 52594)		NA											11	62					0	0	0.001855	0	0
CTRB2	440387	broad.mit.edu	37	16	75238132	75238132	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:75238132G>T	uc002fdr.2	-	7	752	c.719C>A	c.(718-720)ACC>AAC	p.T240N		NM_001025200	NP_001020371	Q6GPI1	CTRB2_HUMAN	chymotrypsin B2 precursor	240	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity				0						GGGCGTGGTGGTAGAGCAGGT	0.667			NA											29	100					1.16021e-09	1.42851e-09	0.007291	1	0
SDR42E1	93517	broad.mit.edu	37	16	82033148	82033148	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:82033148C>A	uc002fgu.2	-	3	878	c.750G>T	c.(748-750)CAG>CAT	p.Q250H		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	250					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						TGAAGTAGGGCTGCCCAGAGG	0.567			NA											64	270					2.6711e-34	5.13373e-34	0.00361	1	0
OR1D4	8385	broad.mit.edu	37	17	2966144	2966145	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:2966144_2966145CC>AA	uc010vra.1	-	1	811_812	c.811_812GG>TT	c.(811-813)GGG>TTG	p.G271L		NM_003552	NP_003543			olfactory receptor, family 1, subfamily D,												0						AGCAAGCGTCCCATAAAAGAGG	0.495			NA											24	88					0	0	0.004672	0	0
MYH2	4620	broad.mit.edu	37	17	10432233	10432233	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:10432233C>A	uc010coi.2	-	27	3646	c.3518G>T	c.(3517-3519)CGG>CTG	p.R1173L	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1173L|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1173	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTCAGCCTCCCGCTTCTTGTT	0.597			NA											69	127					5.46685e-50	1.11603e-49	0.00361	1	0
MAP2K4	6416	broad.mit.edu	37	17	12044543	12044543	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:12044543C>T	uc002gnj.2	+	11	1235	c.1166C>T	c.(1165-1167)CCA>CTA	p.P389L	MAP2K4_uc002gnk.2_Missense_Mutation_p.P400L|MAP2K4_uc010vvi.1_Missense_Mutation_p.P271L|MAP2K4_uc010vvj.1_Missense_Mutation_p.P261L	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	389					cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(2)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		GATCAAATGCCAGCTACTCCC	0.408			NA	D|Mis|N		pancreatic|breast|colorectal								24	58					0	0	0.00333	0	0
HS3ST3B1	9953	broad.mit.edu	37	17	14248435	14248435	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:14248435G>T	uc002goh.1	+	2	975	c.645G>T	c.(643-645)TCG>TCT	p.S215S		NM_006041	NP_006032	Q9Y662	HS3SB_HUMAN	heparan sulfate D-glucosaminyl	215	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CGCGCATCTCGGCCATGTCCA	0.642			NA											22	36					4.26978e-12	5.81103e-12	0.00333	1	0
MFAP4	4239	broad.mit.edu	37	17	19288711	19288711	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:19288711G>T	uc002gvt.2	-	4	322	c.297C>A	c.(295-297)TAC>TAA	p.Y99*	MFAP4_uc002gvr.2_Intron|MFAP4_uc002gvs.2_Nonsense_Mutation_p.Y123*	NM_002404	NP_002395	P55083	MFAP4_HUMAN	microfibrillar-associated protein 4 precursor	99	Fibrinogen C-terminal.				cell adhesion|signal transduction	microfibril	receptor binding				0	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					AGCCCAGCTTGTAGTCATTCC	0.572			NA											19	38					1.96292e-10	2.48679e-10	0.010504	1	0
SLC47A1	55244	broad.mit.edu	37	17	19445753	19445753	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:19445753G>T	uc002gvy.1	+	2	269	c.183G>T	c.(181-183)GTG>GTT	p.V61V	SLC47A1_uc010vyy.1_RNA|SLC47A1_uc002gvx.2_Silent_p.V61V|SLC47A1_uc010vyz.1_Silent_p.V61V|SLC47A1_uc010cqp.1_Silent_p.V61V	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	61	Extracellular (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TAAGCTCCGTGTTCTGTGGCC	0.542			NA											30	79					9.65021e-13	1.36035e-12	0.002096	1	0
C17orf63	55731	broad.mit.edu	37	17	27093631	27093631	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:27093631T>A	uc002hct.1	-	2	322	c.55A>T	c.(55-57)ACG>TCG	p.T19S	C17orf63_uc010wax.1_Missense_Mutation_p.T19S|C17orf63_uc010way.1_Missense_Mutation_p.T19S|C17orf63_uc002hcw.2_5'UTR	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	19										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			TTCATCTGCGTGTGAGAAAGA	0.478			NA											8	17					0	0	0.004482	0	0
PSMD11	5717	broad.mit.edu	37	17	30800864	30800864	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:30800864C>T	uc010cta.1	+	7	729	c.689C>T	c.(688-690)TCA>TTA	p.S230L	PSMD11_uc010wbz.1_Missense_Mutation_p.S230L|PSMD11_uc002hhm.2_Missense_Mutation_p.S230L	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	230	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			ACTGCGTACTCATACTTCTAT	0.388	Ovarian(130;1038 1716 9294 11987 19279)		NA											40	134					0	0	0.007835	0	0
TMEM132E	124842	broad.mit.edu	37	17	32962070	32962070	+	Silent	SNP	G	G	T	rs146893987	byFrequency	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:32962070G>T	uc002hif.2	+	8	1999	c.1671G>T	c.(1669-1671)ACG>ACT	p.T557T		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	557	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		ACAGCAGCACGCTGGCAGGAC	0.617			NA											18	47					1.02788e-11	1.38221e-11	0.00499	1	0
SLFN13	146857	broad.mit.edu	37	17	33768287	33768287	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:33768287C>G	uc002hjk.1	-	4	2351	c.2021G>C	c.(2020-2022)CGT>CCT	p.R674P	SLFN13_uc010wch.1_Missense_Mutation_p.R674P|SLFN13_uc002hjl.2_Missense_Mutation_p.R674P|SLFN13_uc010ctt.2_Missense_Mutation_p.R356P|SLFN13_uc002hjm.2_Missense_Mutation_p.R343P	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	674						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATCTTCAGTACGGAAATTCTG	0.433			NA											55	169					0	0	0.00361	0	0
LYZL6	57151	broad.mit.edu	37	17	34263771	34263771	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:34263771C>A	uc002hkj.1	-	3	515	c.365G>T	c.(364-366)GGG>GTG	p.G122V	LYZL6_uc002hkk.1_Missense_Mutation_p.G122V	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	122					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTTGTTCATCCCCCGTGCTCC	0.577			NA											39	163					3.78316e-11	4.95204e-11	0.00623	1	0
FBXO47	494188	broad.mit.edu	37	17	37119170	37119170	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:37119170G>A	uc002hrc.2	-	2	309	c.109C>T	c.(109-111)CCC>TCC	p.P37S		NM_001008777	NP_001008777	Q5MNV8	FBX47_HUMAN	F-box protein 47	37											0						GTTGATATGGGTTGAAAGCCT	0.353			NA											26	92					0	0	0.004656	0	0
KIF18B	146909	broad.mit.edu	37	17	43004447	43004447	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:43004447C>A	uc010wji.1	-	14	2387	c.2286_splice	c.e14-1	p.R762_splice	KIF18B_uc002iht.2_Splice_Site_p.R771_splice|KIF18B_uc010wjh.1_Splice_Site_p.R759_splice	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				CACAGGTGCCCTGGGGAGGGA	0.463			NA											11	31					5.16669e-11	6.7295e-11	0.000978	1	0
MAP3K14	9020	broad.mit.edu	37	17	43364128	43364128	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:43364128G>A	uc002iiw.1	-	6	931	c.822C>T	c.(820-822)CCC>CCT	p.P274P	MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_5'UTR	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	274					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						GAGGTTTCCAGGGCTGGAGAG	0.622			NA											9	21					0	0	0.000978	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43531202	43531202	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:43531202A>T	uc002ija.2	-	7	2186	c.2016T>A	c.(2014-2016)TTT>TTA	p.F672L	PLEKHM1_uc010wjm.1_Missense_Mutation_p.F644L|PLEKHM1_uc002ijb.2_Missense_Mutation_p.F147L|PLEKHM1_uc010wjn.1_Missense_Mutation_p.F621L|PLEKHM1_uc002ijc.2_Missense_Mutation_p.F126L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	672					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					ACGACCAGTCAAACTGTGTGC	0.612			NA											40	131					0	0	0.00874	0	0
IMP5	162540	broad.mit.edu	37	17	43922293	43922293	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:43922293C>T	uc010wka.1	+	1	21	c.21C>T	c.(19-21)CTC>CTT	p.L7L	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	7						integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		TGGGCTTCCTCCTCCCCGTGG	0.627	NSCLC(24;34 1393 18470)		NA											19	74					0	0	0.007413	0	0
MAPT	4137	broad.mit.edu	37	17	44067349	44067349	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:44067349G>T	uc002ijr.3	+	8	1608	c.1288G>T	c.(1288-1290)GCT>TCT	p.A430S	MAPT_uc010dau.2_Missense_Mutation_p.A430S|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	430					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CTCCAGCCCTGCTGTGTGCCC	0.522			NA											116	388					3.39137e-47	6.86993e-47	0.00361	1	0
KIF2B	84643	broad.mit.edu	37	17	51901354	51901354	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:51901354G>T	uc002iua.2	+	1	1116	c.960G>T	c.(958-960)ACG>ACT	p.T320T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	320	Kinesin-motor.			T -> K (in Ref. 2; BAB71406).	blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TTTCAGGAACGGCCCAAGATT	0.522			NA											41	129					3.61848e-18	5.72562e-18	0.007835	1	0
DDX42	11325	broad.mit.edu	37	17	61864590	61864590	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:61864590A>C	uc002jbu.2	+	3	438	c.181A>C	c.(181-183)AAA>CAA	p.K61Q	DDX42_uc002jbv.2_Missense_Mutation_p.K61Q	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	61					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						TTCTTTCTACAAAATTGGATC	0.448			NA											44	131					0	0	0.00361	0	0
SCN4A	6329	broad.mit.edu	37	17	62019252	62019252	+	Missense_Mutation	SNP	C	C	T	rs150423825	by1000genomes	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:62019252C>T	uc002jds.1	-	24	4467	c.4390G>A	c.(4390-4392)GGG>AGG	p.G1464R		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1464	Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).|IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CCCTTGGCCCCGCGGATCAGC	0.617			NA											22	42					0	0	0.002299	0	0
TEX2	55852	broad.mit.edu	37	17	62230430	62230430	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:62230430C>G	uc002jec.2	-	10	3188	c.3015G>C	c.(3013-3015)GAG>GAC	p.E1005D	TEX2_uc002jed.2_Missense_Mutation_p.E1012D|TEX2_uc002jee.2_Missense_Mutation_p.E1005D	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	1005					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TAAACTCTGTCTCTGTTGCTT	0.388			NA											16	88					0	0	0.003163	0	0
ABCA10	10349	broad.mit.edu	37	17	67190582	67190582	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:67190582C>A	uc010dfa.1	-	13	2168	c.1289G>T	c.(1288-1290)GGA>GTA	p.G430V	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.G31V	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	430	ATP 1 (Potential).|ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTTACCAGCTCCATTATGCCC	0.333			NA											24	119					1.66031e-10	2.1136e-10	0.003954	1	0
EPB41L3	23136	broad.mit.edu	37	18	5416157	5416157	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:5416157C>A	uc002kmt.1	-	13	1813	c.1727G>T	c.(1726-1728)AGA>ATA	p.R576I	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	576	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AGTTTGCTGTCTGTAGCTAAA	0.577			NA											41	132					1.22674e-20	2.03083e-20	0.00874	1	0
TUBB6	84617	broad.mit.edu	37	18	12325202	12325202	+	Silent	SNP	G	G	C	rs148645230	byFrequency	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:12325202G>C	uc002kqw.2	+	4	459	c.414G>C	c.(412-414)TCG>TCC	p.S138S	TUBB6_uc002kqv.2_Silent_p.S66S|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Silent_p.S101S|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	138					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		TCACGCACTCGCTGGGCGGCG	0.657			NA											35	61					0	0	0.003271	0	0
C18orf1	753	broad.mit.edu	37	18	13645329	13645329	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:13645329G>T	uc002ksa.2	+	7	1262	c.594G>T	c.(592-594)ATG>ATT	p.M198I	C18orf1_uc002ksb.2_Missense_Mutation_p.M180I|C18orf1_uc002kse.2_Missense_Mutation_p.M161I|C18orf1_uc002ksf.2_Missense_Mutation_p.M143I|C18orf1_uc002ksg.1_Missense_Mutation_p.M121I|C18orf1_uc002ksh.1_Missense_Mutation_p.M140I|C18orf1_uc002ksi.1_Missense_Mutation_p.M122I	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	198	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AACAGCAGATGGAACTCAACC	0.567			NA											37	122					7.61165e-28	1.39488e-27	0.003755	1	0
ROCK1	6093	broad.mit.edu	37	18	18622649	18622649	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:18622649T>C	uc002kte.2	-	7	1638	c.697A>G	c.(697-699)ACA>GCA	p.T233A		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	233	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CCAACCGCTGTATCACATCGT	0.378			NA											35	96					0	0	0.003755	0	0
LAMA3	3909	broad.mit.edu	37	18	21416983	21416983	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:21416983G>T	uc002kuq.2	+	25	3109	c.3023G>T	c.(3022-3024)CGC>CTC	p.R1008L	LAMA3_uc002kur.2_Missense_Mutation_p.R1008L	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1008	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACATGAGCCGCATCGCCATG	0.453			NA											16	76					8.00594e-06	8.81101e-06	0.007413	1	0
ZNF521	25925	broad.mit.edu	37	18	22902056	22902056	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:22902056C>A	uc002kvk.2	-	3	383	c.136G>T	c.(136-138)GTG>TTG	p.V46L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.V46L|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	46					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CAGCTGTGCACAGCTTCGTCT	0.463			NA	T	PAX5	ALL								46	96					1.06522e-23	1.84077e-23	0.003214	1	0
CHST9	83539	broad.mit.edu	37	18	24604116	24604116	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:24604116C>T	uc002kwd.2	-	3	364	c.166G>A	c.(166-168)GGA>AGA	p.G56R	C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_5'UTR|CHST9_uc002kwe.2_Missense_Mutation_p.G56R	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	56	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					TTCACTGGTCCCCATCCTGAA	0.378			NA											8	39					0	0	0.004482	0	0
CDH2	1000	broad.mit.edu	37	18	25727729	25727729	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:25727729C>A	uc002kwg.2	-	2	539	c.80G>T	c.(79-81)GGT>GTT	p.G27V		NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	27					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TGCGATTTCACCAGAAGCCTC	0.413			NA											9	36					3.86212e-05	4.16897e-05	0.008291	1	0
SLC39A6	25800	broad.mit.edu	37	18	33706321	33706321	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:33706321T>A	uc010dmy.2	-	2	940	c.650A>T	c.(649-651)GAT>GTT	p.D217V	SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	217	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						GCTGCTTACATCTTTGGGGAA	0.498			NA											68	159					0	0	0.00361	0	0
FHOD3	80206	broad.mit.edu	37	18	34349242	34349242	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:34349242T>A	uc002kzt.1	+	23	4136	c.4039T>A	c.(4039-4041)TGG>AGG	p.W1347R	FHOD3_uc002kzs.1_Missense_Mutation_p.W1364R|FHOD3_uc010dmz.1_Missense_Mutation_p.W1079R|FHOD3_uc010dnb.1_Silent_p.P284P	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1347					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTAGTTCCTGGACTATGGG	0.473			NA											35	59					0	0	0.005524	0	0
CELF4	56853	broad.mit.edu	37	18	34854816	34854816	+	Silent	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:34854816G>C	uc002lae.2	-	5	1005	c.609C>G	c.(607-609)GCC>GCG	p.A203A	CELF4_uc010dnd.1_Silent_p.A202A|CELF4_uc002lag.2_Silent_p.A193A|CELF4_uc002laf.2_Silent_p.A198A|CELF4_uc002lai.2_Silent_p.A188A|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_5'Flank	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	203	Sufficient for RNA-binding and MSE- dependent splicing activity.|RRM 2.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CCTGCGCCTCGGCGTGGGAGG	0.736			NA											3	13					0	0	0.004672	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555227	44555227	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:44555227G>A	uc010xdb.1	-	1	1223	c.987C>T	c.(985-987)GCC>GCT	p.A329A	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	329	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GGAGCTGGCAGGCAGGCCTGG	0.667			NA											15	557					0	0	0.002299	0	0
MAPK4	5596	broad.mit.edu	37	18	48248367	48248367	+	Nonsense_Mutation	SNP	G	G	T	rs66911538		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:48248367G>T	uc002lev.2	+	4	1751	c.751G>T	c.(751-753)GAA>TAA	p.E251*	MAPK4_uc010xdm.1_Nonsense_Mutation_p.E40*|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	251	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		AATCCGGGAGGAAGACAAGGA	0.577			NA											14	62					0.00185496	0.00194118	0.001855	1	0
SERPINB2	5055	broad.mit.edu	37	18	61570386	61570386	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:61570386G>T	uc010xeu.1	+	9	1428	c.1095G>T	c.(1093-1095)GAG>GAT	p.E365D	SERPINB2_uc002ljo.2_Missense_Mutation_p.E365D|SERPINB2_uc010dqh.2_Missense_Mutation_p.E295D|SERPINB2_uc002ljp.1_Intron|SERPINB2_uc002ljq.1_Intron	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	365					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	TGAATGAGGAGGGCACTGAAG	0.502			NA											18	65					7.45023e-12	1.00699e-11	0.010504	1	0
CDH7	1005	broad.mit.edu	37	18	63511299	63511299	+	Silent	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr18:63511299G>C	uc002ljz.2	+	7	1558	c.1233G>C	c.(1231-1233)GTG>GTC	p.V411V	CDH7_uc002lka.2_Silent_p.V411V|CDH7_uc002lkb.2_Silent_p.V411V	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	411	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATAGCCCTGTGAGGTAAAAAC	0.418			NA											39	78					0	0	0.00623	0	0
MUC16	94025	broad.mit.edu	37	19	9020128	9020128	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:9020128A>T	uc002mkp.2	-	21	37571	c.37367T>A	c.(37366-37368)GTG>GAG	p.V12456E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12458	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGCATCCACTCCAGTGGC	0.517			NA											48	92					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9047436	9047436	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:9047436C>A	uc002mkp.2	-	5	34399	c.34195G>T	c.(34195-34197)GAT>TAT	p.D11399Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11401	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGGTACATCAGGTGAGACA	0.463			NA											48	86					1.17673e-23	2.02902e-23	0.00361	1	0
ACP5	54	broad.mit.edu	37	19	11687570	11687570	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:11687570A>T	uc002msg.3	-	3	496	c.350T>A	c.(349-351)GTC>GAC	p.V117D	ACP5_uc002msh.3_Missense_Mutation_p.V117D|ACP5_uc002msi.3_Missense_Mutation_p.V117D|ACP5_uc002msj.3_Missense_Mutation_p.V117D|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	117					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						CTGGGCAGAGACATTGCCAAG	0.562			NA											26	145					0	0	0.00632	0	0
F2RL3	9002	broad.mit.edu	37	19	17000732	17000732	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:17000732C>T	uc002nfa.2	+	2	633	c.458C>T	c.(457-459)ACG>ATG	p.T153M		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	153	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CGCCTGGCCACGGCCGCACTC	0.736			NA											4	5					0	0	0.009096	0	0
ZNF208	7757	broad.mit.edu	37	19	22154978	22154978	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:22154978G>T	uc002nqp.2	-	5	2707	c.2558C>A	c.(2557-2559)GCC>GAC	p.A853D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGACTTATAGGCTTTGCCACA	0.368			NA											16	29					2.32078e-09	2.83093e-09	0.003163	1	0
TMEM149	79713	broad.mit.edu	37	19	36230498	36230498	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:36230498A>G	uc002obc.2	-	5	852	c.751T>C	c.(751-753)TCT>CCT	p.S251P	TMEM149_uc002obb.2_Missense_Mutation_p.S63P|TMEM149_uc002obd.3_Missense_Mutation_p.S251P|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.S331P	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	251	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGAGGCGAGACAGGGGTTGT	0.627			NA											37	90					0	0	0.006999	0	0
ZNF570	148268	broad.mit.edu	37	19	37976118	37976118	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:37976118A>T	uc002ogk.1	+	5	2123	c.1594A>T	c.(1594-1596)AAT>TAT	p.N532Y	ZNF570_uc010efl.1_Missense_Mutation_p.N588Y|ZNF570_uc010xtr.1_Missense_Mutation_p.N329Y	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	532					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			caacccagtcaatcaccaagt	0.174			NA											11	32					0	0	0.000978	0	0
RYR1	6261	broad.mit.edu	37	19	38976573	38976573	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:38976573C>A	uc002oit.2	+	34	5408	c.5278C>A	c.(5278-5280)CAT>AAT	p.H1760N	RYR1_uc002oiu.2_Missense_Mutation_p.H1760N	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1760	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCACCCCCGGCATGGCCTGCC	0.642			NA											14	64					0.00244969	0.00254329	0.00245	1	0
FCGBP	8857	broad.mit.edu	37	19	40411754	40411754	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:40411754C>G	uc002omp.3	-	7	3882	c.3874G>C	c.(3874-3876)GCC>CCC	p.A1292P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1292	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCAGGACGGCAAACCGATGC	0.637			NA											38	77					0	0	0.00361	0	0
LIG1	3978	broad.mit.edu	37	19	48653099	48653099	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:48653099C>A	uc002pia.1	-	9	818	c.698_splice	c.e9-1	p.T233_splice	LIG1_uc010xze.1_Splice_Site|LIG1_uc002phz.1_Splice_Site|LIG1_uc002pib.1_Splice_Site|LIG1_uc010xzf.1_Splice_Site_p.T165_splice|LIG1_uc010xzg.1_Splice_Site_p.T202_splice|LIG1_uc010xzh.1_Splice_Site	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I						anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	TTCCGGGGGGCTAGGAATGAA	0.582			NA						NER					3	24					0.004672	0.00481247	0.004672	1	0
TMEM143	55260	broad.mit.edu	37	19	48845927	48845927	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:48845927C>T	uc002pix.1	-	6	844	c.835G>A	c.(835-837)GCC>ACC	p.A279T	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.A244T|TMEM143_uc010xzn.1_Missense_Mutation_p.A214T|TMEM143_uc010elw.1_Missense_Mutation_p.A179T|TMEM143_uc010xzo.1_Missense_Mutation_p.A69T	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	279						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TTGAGCAGGGCGCGCTGCAGG	0.642			NA											15	38					0	0	0.003163	0	0
GPR32	2854	broad.mit.edu	37	19	51274539	51274539	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:51274539C>T	uc010ycf.1	+	1	682	c.682C>T	c.(682-684)CCC>TCC	p.P228S		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	228	Helical; Name=5; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTTCCTGGGGCCCTTAGCAAT	0.597	Esophageal Squamous(113;152 1581 5732 15840 44398)		NA											20	41					0	0	0.008871	0	0
KLK15	55554	broad.mit.edu	37	19	51330233	51330233	+	Missense_Mutation	SNP	G	G	T	rs7247190		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:51330233G>T	uc002ptl.2	-	3	413	c.382C>A	c.(382-384)CCC>ACC	p.P128T	KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Missense_Mutation_p.P128T|KLK15_uc002pto.2_Missense_Mutation_p.P127T|KLK15_uc010ych.1_Intron|KLK15_uc010yci.1_Missense_Mutation_p.P127T|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	128	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAACGCGTGGGTAGCACCGCG	0.711	Pancreas(140;10 2513 7143 9246)		NA											27	52					6.12954e-19	9.79731e-19	0.004656	1	0
NLRP12	91662	broad.mit.edu	37	19	54304586	54304586	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:54304586T>C	uc002qch.3	-	7	2871	c.2651A>G	c.(2650-2652)CAG>CGG	p.Q884R	NLRP12_uc010eqw.2_Missense_Mutation_p.Q167R|NLRP12_uc002qci.3_Missense_Mutation_p.Q884R|NLRP12_uc002qcj.3_Missense_Mutation_p.Q885R|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	884					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding	p.Q884H(1)		ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCAGGCTCTGGTTCACACT	0.592			NA											26	64					0	0	0.008361	0	0
NLRP4	147945	broad.mit.edu	37	19	56369712	56369712	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:56369712C>A	uc002qmd.3	+	3	1375	c.953C>A	c.(952-954)CCG>CAG	p.P318Q	NLRP4_uc002qmf.2_Missense_Mutation_p.P243Q|NLRP4_uc010etf.2_Missense_Mutation_p.P149Q	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	318	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTCAAAGACCCGAAAAGAGCC	0.483			NA											37	58					1.04352e-10	1.34142e-10	0.003755	1	0
ZIM3	114026	broad.mit.edu	37	19	57646630	57646630	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr19:57646630C>T	uc002qnz.1	-	5	1461	c.1075G>A	c.(1075-1077)GGG>AGG	p.G359R		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCTCTCTTCCCAGTGTGAATT	0.393			NA											65	129					0	0	0.00361	0	0
TTC15	51112	broad.mit.edu	37	2	3428348	3428348	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:3428348C>T	uc002qxm.1	+	5	1537	c.1331C>T	c.(1330-1332)GCT>GTT	p.A444V	TTC15_uc002qxn.1_Missense_Mutation_p.A444V|TTC15_uc010ewm.1_Missense_Mutation_p.A444V	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	444							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		TTCCAGAATGCTGAGATGGAA	0.448			NA											87	178					0	0	0.00361	0	0
NBAS	51594	broad.mit.edu	37	2	15470780	15470780	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:15470780T>A	uc002rcc.1	-	36	4315	c.4289A>T	c.(4288-4290)CAG>CTG	p.Q1430L	NBAS_uc010exl.1_Missense_Mutation_p.Q502L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1430										ovary(2)|liver(1)|skin(1)	4						ACTGACGGCCTGCAGCACCGC	0.493			NA											25	62					0	0	0.004656	0	0
SUPT7L	9913	broad.mit.edu	37	2	27884203	27884203	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:27884203C>A	uc002rlh.1	-	3	410	c.67G>T	c.(67-69)GAT>TAT	p.D23Y	SUPT7L_uc002rli.1_Missense_Mutation_p.D23Y|SUPT7L_uc010ymf.1_Intron|SUPT7L_uc002rlj.1_Missense_Mutation_p.D21Y|SUPT7L_uc010ezh.1_Missense_Mutation_p.D21Y|SLC4A1AP_uc002rlk.3_5'Flank	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	23					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					GGGAGCAAATCGAAGGAACTT	0.507			NA											28	58					3.57733e-08	4.1824e-08	0.009535	1	0
CAPN13	92291	broad.mit.edu	37	2	30955326	30955326	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:30955326C>A	uc002rnn.2	-	19	2081	c.1905G>T	c.(1903-1905)CTG>CTT	p.L635L	CAPN13_uc002rnm.2_RNA	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	635					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CAAGCCGCATCAGGAAGCAGA	0.607			NA											12	17					2.61681e-11	3.43103e-11	0.00245	1	0
EPAS1	2034	broad.mit.edu	37	2	46611777	46611777	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:46611777G>T	uc002ruv.2	+	16	3079	c.2591G>T	c.(2590-2592)AGA>ATA	p.R864I	EPAS1_uc002ruw.2_Missense_Mutation_p.R330I	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	864	CTAD.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GACCTCCTCAGAGCCCTGGAC	0.607			NA											10	93					7.48243e-07	8.41106e-07	0.006214	1	0
ASB3	51130	broad.mit.edu	37	2	53943863	53943863	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:53943863G>C	uc002rxg.1	-	6	757	c.622C>G	c.(622-624)CAA>GAA	p.Q208E	ASB3_uc002rxh.1_Missense_Mutation_p.Q135E|ASB3_uc002rxi.3_Missense_Mutation_p.Q246E|ASB3_uc010yoo.1_Missense_Mutation_p.Q125E	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	208					intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCAAGGCTTGACAATTGACA	0.378			NA											8	234					0	0	0.004482	0	0
CCDC88A	55704	broad.mit.edu	37	2	55549736	55549736	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:55549736C>A	uc002ryv.2	-	18	3929	c.3087G>T	c.(3085-3087)TGG>TGT	p.W1029C	CCDC88A_uc010yoz.1_Missense_Mutation_p.W1030C|CCDC88A_uc010ypa.1_Missense_Mutation_p.W1029C|CCDC88A_uc002ryu.2_Missense_Mutation_p.W312C|CCDC88A_uc002rys.2_Missense_Mutation_p.W15C|CCDC88A_uc002ryw.2_Missense_Mutation_p.W313C|CCDC88A_uc010fby.1_Intron	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1030	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTTCTCGCTCCCATTTGTTGT	0.328			NA											93	118					1.7666e-45	3.56031e-45	0.00361	1	0
BCL11A	53335	broad.mit.edu	37	2	60773198	60773198	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:60773198G>T	uc002sae.1	-	2	521	c.293C>A	c.(292-294)CCC>CAC	p.P98H	BCL11A_uc002sab.2_Missense_Mutation_p.P98H|BCL11A_uc002sac.2_Missense_Mutation_p.P98H|BCL11A_uc010ypi.1_5'UTR|BCL11A_uc010ypj.1_Missense_Mutation_p.P98H|BCL11A_uc002saf.1_Missense_Mutation_p.P98H|BCL11A_uc010fcg.2_Missense_Mutation_p.P98H	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	98	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AACCTCCACGGGATTGGATGC	0.473			NA	T	IGH@	B-CLL								41	125					3.09479e-21	5.1558e-21	0.006999	1	0
DYSF	8291	broad.mit.edu	37	2	71827833	71827833	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:71827833G>T	uc002sie.2	+	34	4080	c.3704G>T	c.(3703-3705)GGT>GTT	p.G1235V	DYSF_uc010feg.2_Missense_Mutation_p.G1266V|DYSF_uc010feh.2_Missense_Mutation_p.G1221V|DYSF_uc002sig.3_Missense_Mutation_p.G1221V|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.G1235V|DYSF_uc010fef.2_Missense_Mutation_p.G1252V|DYSF_uc010fei.2_Missense_Mutation_p.G1252V|DYSF_uc010fek.2_Missense_Mutation_p.G1253V|DYSF_uc010fej.2_Missense_Mutation_p.G1222V|DYSF_uc010fel.2_Missense_Mutation_p.G1222V|DYSF_uc010feo.2_Missense_Mutation_p.G1267V|DYSF_uc010fem.2_Missense_Mutation_p.G1236V|DYSF_uc010fen.2_Missense_Mutation_p.G1253V|DYSF_uc002sif.2_Missense_Mutation_p.G1236V|DYSF_uc010yqy.1_Missense_Mutation_p.G116V|DYSF_uc010yqz.1_5'Flank	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1235	Cytoplasmic (Potential).|C2 4.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTGGTCTAGGGTGCAGACGAG	0.577			NA											106	192					2.68927e-46	5.43371e-46	0.00361	1	0
LBX2	85474	broad.mit.edu	37	2	74725064	74725064	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:74725064A>T	uc002slv.3	-	2	592	c.587T>A	c.(586-588)GTG>GAG	p.V196E	LBX2_uc002slw.2_Missense_Mutation_p.V192E	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	196						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAATCGTCCACCTGTATCTC	0.667			NA											19	27					0	0	0.003954	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745991	77745991	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:77745991C>A	uc002snr.2	-	3	1419	c.1004G>T	c.(1003-1005)AGC>ATC	p.S335I	LRRTM4_uc002snq.2_Missense_Mutation_p.S335I|LRRTM4_uc002sns.2_Missense_Mutation_p.S335I|LRRTM4_uc002snt.2_Missense_Mutation_p.S336I	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	335	LRRCT.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TATCATGGTGCTTTCCTTATT	0.393			NA											5	26					1.23904e-05	1.35606e-05	0.000602	1	0
ATOH8	84913	broad.mit.edu	37	2	85991289	85991289	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:85991289G>C	uc002sqn.2	+	2	1348	c.944G>C	c.(943-945)CGT>CCT	p.R315P	ATOH8_uc002sqm.3_Missense_Mutation_p.R315P	NM_032827	NP_116216	Q96SQ7	ATOH8_HUMAN	atonal homolog 8	315					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GCCGAGGGACGTGCCAAGAAG	0.657			NA											11	80					0	0	0.003163	0	0
CD8A	925	broad.mit.edu	37	2	87017643	87017643	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:87017643G>C	uc002srt.2	-	2	1100	c.211C>G	c.(211-213)CTA>GTA	p.L71V	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.L71V|CD8A_uc010ytn.1_Missense_Mutation_p.L112V|CD8A_uc002sru.2_Missense_Mutation_p.L71V	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	71	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						GAGAGGTATAGGAGGAAGGTG	0.667			NA											30	107					0	0	0.003271	0	0
POLR1B	84172	broad.mit.edu	37	2	113304689	113304689	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:113304689G>C	uc002thw.2	+	2	858	c.278G>C	c.(277-279)TGC>TCC	p.C93S	POLR1B_uc010fkn.2_Intron|POLR1B_uc002thx.2_5'UTR|POLR1B_uc010fko.2_Missense_Mutation_p.C93S|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.C131S|POLR1B_uc002thy.2_5'UTR|POLR1B_uc010yxo.1_Intron	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	93					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						GGGACCATCTGCAAAGAGGCC	0.458	Ovarian(16;256 576 9537 23969 41147)		NA											26	90					0	0	0.003954	0	0
MARCO	8685	broad.mit.edu	37	2	119727850	119727850	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:119727850C>A	uc002tln.1	+	3	492	c.360C>A	c.(358-360)CTC>CTA	p.L120L	MARCO_uc010yyf.1_Silent_p.L42L	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	120	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGCCCAACTCACCTGGGTCC	0.612	GBM(8;18 374 7467 11269 32796)		NA											17	77					5.3912e-06	5.97506e-06	0.006122	1	0
MARCO	8685	broad.mit.edu	37	2	119749443	119749443	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:119749443G>T	uc002tln.1	+	14	1331	c.1199G>T	c.(1198-1200)GGA>GTA	p.G400V	MARCO_uc010yyf.1_Missense_Mutation_p.G322V	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	400	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGAGACCAGGGAGTGAAAGGT	0.547	GBM(8;18 374 7467 11269 32796)		NA											11	16					5.50884e-06	6.07978e-06	0.001368	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125281944	125281944	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:125281944G>T	uc002tno.2	+	9	1753	c.1389G>T	c.(1387-1389)ACG>ACT	p.T463T	CNTNAP5_uc010flu.2_Silent_p.T464T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	463	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACCGCATCACGCTCACTCTGG	0.493			NA											23	77					3.62473e-10	4.51944e-10	0.001882	1	0
GPR148	344561	broad.mit.edu	37	2	131487640	131487640	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:131487640G>T	uc002trv.1	+	1	918	c.916G>T	c.(916-918)GAG>TAG	p.E306*		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	306	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					AGCTAACAGTGAGGTACTCAT	0.597			NA											16	126					2.35188e-11	3.10433e-11	0.006122	1	0
FAM123C	205147	broad.mit.edu	37	2	131520903	131520903	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:131520903G>T	uc002trw.2	+	2	1448	c.1258G>T	c.(1258-1260)GAC>TAC	p.D420Y	FAM123C_uc010fmv.2_Missense_Mutation_p.D420Y|FAM123C_uc010fms.1_Missense_Mutation_p.D420Y|FAM123C_uc010fmt.1_Missense_Mutation_p.D420Y|FAM123C_uc010fmu.1_Missense_Mutation_p.D420Y	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	420										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CTACAGTGGGGACGCCCTCTA	0.622			NA											18	66					2.21704e-12	3.07575e-12	0.00278	1	0
LRP1B	53353	broad.mit.edu	37	2	140995750	140995750	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:140995750C>A	uc002tvj.1	-	89	14503	c.13531G>T	c.(13531-13533)GAT>TAT	p.D4511Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4511	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGCCAGGATCTAAAAGACCT	0.373	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			30	95					6.38683e-12	8.66235e-12	0.008361	1	0
LRP1B	53353	broad.mit.edu	37	2	141459809	141459809	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:141459809T>C	uc002tvj.1	-	39	7175	c.6203A>G	c.(6202-6204)GAC>GGC	p.D2068G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2068	Extracellular (Potential).|LDL-receptor class B 22.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTCTCAAGGTCGATTCTCTC	0.413	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			43	95					0	0	0.00361	0	0
ZEB2	9839	broad.mit.edu	37	2	145274897	145274897	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:145274897C>A	uc002tvu.2	-	2	501	c.21G>T	c.(19-21)GCG>GCT	p.A7A	ZEB2_uc002tvv.2_Silent_p.A2A|ZEB2_uc010zbm.1_Silent_p.A2A|ZEB2_uc010fnp.2_Silent_p.A2A|ZEB2_uc010fnq.1_Silent_p.A36A|ZEB2_uc002tvw.2_Silent_p.A2A|ZEB2_uc002tvx.1_RNA|ZEB2_uc002tvy.2_Silent_p.A36A|ZEB2_uc002tvz.2_RNA|ZEB2_uc002twa.2_RNA	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	7						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGGGGCCATCCGCCATGATCG	0.587	Melanoma(33;1235 1264 5755 16332)		NA											12	77					0.00010058	0.00010754	0.001368	1	0
NEB	4703	broad.mit.edu	37	2	152566225	152566225	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:152566225T>A	uc010fnx.2	-	12	1171	c.980A>T	c.(979-981)CAG>CTG	p.Q327L	NEB_uc010fny.1_5'Flank	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	327	Nebulin 8.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTTTCGGTCTGCATGAAGTA	0.398			NA											4	16					0	0	0.009096	0	0
BAZ2B	29994	broad.mit.edu	37	2	160229615	160229615	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:160229615C>G	uc002uao.2	-	27	4506	c.4154G>C	c.(4153-4155)CGG>CCG	p.R1385P	BAZ2B_uc002uap.2_Missense_Mutation_p.R1349P	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AATCCAGTACCGGCGTCTGTA	0.428			NA											12	85					0	0	0.00245	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294973	160294973	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:160294973C>A	uc002uao.2	-	8	1486	c.1134G>T	c.(1132-1134)ACG>ACT	p.T378T	BAZ2B_uc002uap.2_Silent_p.T376T|BAZ2B_uc002uas.1_Silent_p.T315T|BAZ2B_uc002uau.1_Silent_p.T376T|BAZ2B_uc002uaq.1_Silent_p.T306T|BAZ2B_uc002uat.3_3'UTR|BAZ2B_uc010fop.1_Silent_p.T376T	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						ACACCAATCCCGTAGACTGTA	0.408			NA											18	142					7.05477e-17	1.08366e-16	0.00499	1	0
LY75	4065	broad.mit.edu	37	2	160741774	160741774	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:160741774G>A	uc002ubc.3	-	6	1013	c.944C>T	c.(943-945)TCC>TTC	p.S315F	LY75_uc002ubb.3_Missense_Mutation_p.S315F|LY75_uc010fos.2_Missense_Mutation_p.S315F|LY75_uc010fot.1_Missense_Mutation_p.S315F	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	315	Extracellular (Potential).|C-type lectin 1.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TGCACAGCTGGAGCCACCTAT	0.448			NA											34	117					0	0	0.005524	0	0
SLC4A10	57282	broad.mit.edu	37	2	162661084	162661084	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:162661084G>T	uc002ubx.3	+	3	440	c.256G>T	c.(256-258)GGA>TGA	p.G86*	SLC4A10_uc010fpa.1_Nonsense_Mutation_p.G98*|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Nonsense_Mutation_p.G86*|SLC4A10_uc010zcs.1_Nonsense_Mutation_p.G97*	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	86	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						ATTAGAGGATGGAAGGGAGTC	0.378			NA											3	32					0.004672	0.00481247	0.004672	1	0
SCN2A	6326	broad.mit.edu	37	2	166198918	166198918	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:166198918G>T	uc002udc.2	+	15	2791	c.2501G>T	c.(2500-2502)AGT>ATT	p.S834I	SCN2A_uc002udd.2_Missense_Mutation_p.S834I|SCN2A_uc002ude.2_Missense_Mutation_p.S834I	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	834	II.|Helical; Name=S3 of repeat II; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	GTGAGCCTTAGTTTAATGGAA	0.358			NA											43	128					6.68952e-21	1.10976e-20	0.003214	1	0
B3GALT1	8708	broad.mit.edu	37	2	168726315	168726315	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:168726315C>A	uc002udz.1	+	2	1117	c.766C>A	c.(766-768)CTC>ATC	p.L256I		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	256	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						CAAGACCTCACTCCACACAAG	0.488			NA											46	84					9.84934e-19	1.57111e-18	0.002522	1	0
MYO3B	140469	broad.mit.edu	37	2	171509600	171509600	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:171509600C>A	uc002ufy.2	+	35	4138	c.3995C>A	c.(3994-3996)TCC>TAC	p.S1332Y	MYO3B_uc002ufz.2_Missense_Mutation_p.S1305Y|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA|uc002ugc.1_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1332					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TTTTCTTCATCCTCAAAAGGA	0.418			NA											18	150					1.56452e-12	2.17817e-12	0.007413	1	0
RBM45	129831	broad.mit.edu	37	2	178977516	178977516	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:178977516G>T	uc002ulv.2	+	1	335	c.243G>T	c.(241-243)AGG>AGT	p.R81S		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	81	RRM 1.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			AGGCCTGCAGGGCCATGGAGG	0.652			NA											25	79					1.77063e-15	2.63754e-15	0.005443	1	0
TTN	7273	broad.mit.edu	37	2	179427841	179427841	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:179427841G>A	uc010zfg.1	-	275	75538	c.75314C>T	c.(75313-75315)CCA>CTA	p.P25105L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P18800L|TTN_uc010zfi.1_Missense_Mutation_p.P18733L|TTN_uc010zfj.1_Missense_Mutation_p.P18608L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26032							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTATTTCTGGTGGCTCTAT	0.463			NA											72	224					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179433781	179433781	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:179433781A>C	uc010zfg.1	-	275	69598	c.69374T>G	c.(69373-69375)ATT>AGT	p.I23125S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I16820S|TTN_uc010zfi.1_Missense_Mutation_p.I16753S|TTN_uc010zfj.1_Missense_Mutation_p.I16628S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24052							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAACCTTAATTGGATCAGC	0.443			NA											48	136					0	0	0.003214	0	0
TTN	7273	broad.mit.edu	37	2	179452755	179452755	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:179452755G>C	uc010zfg.1	-	254	55899	c.55675C>G	c.(55675-55677)CGC>GGC	p.R18559G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12254G|TTN_uc010zfi.1_Missense_Mutation_p.R12187G|TTN_uc010zfj.1_Missense_Mutation_p.R12062G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19486							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCCTTGCGTACAAGCTGT	0.473			NA											8	62					0	0	0.00308	0	0
TTN	7273	broad.mit.edu	37	2	179565924	179565924	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:179565924G>T	uc010zfg.1	-	108	27097	c.26873C>A	c.(26872-26874)CCT>CAT	p.P8958H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P5619H|TTN_uc010fre.1_Missense_Mutation_p.P69H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9885							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCACAGGAGGGATTTCTGA	0.368			NA											48	141					6.31075e-24	1.09535e-23	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179567349	179567349	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:179567349C>A	uc010zfg.1	-	104	26757	c.26533G>T	c.(26533-26535)GTG>TTG	p.V8845L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V5506L|TTN_uc010fre.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9772							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTCACTCACCACGATGTTC	0.403			NA											39	96					8.73648e-17	1.33937e-16	0.004289	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803686	185803686	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:185803686C>A	uc002uph.2	+	4	4157	c.3563C>A	c.(3562-3564)CCC>CAC	p.P1188H		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1188						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CCATCTTTACCCCATGCACTC	0.473			NA											37	288					1.26612e-14	1.85446e-14	0.003271	1	0
COL3A1	1281	broad.mit.edu	37	2	189859297	189859297	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:189859297G>T	uc002uqj.1	+	19	1441	c.1324G>T	c.(1324-1326)GAG>TAG	p.E442*		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	442	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGCCAAAGGAGAGCCCGGACC	0.398			NA											16	69					3.41278e-10	4.27547e-10	0.00499	1	0
COL5A2	1290	broad.mit.edu	37	2	189929366	189929366	+	Silent	SNP	G	G	T	rs145258293		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:189929366G>T	uc002uqk.2	-	25	1908	c.1633C>A	c.(1633-1635)CGG>AGG	p.R545R	COL5A2_uc010frx.2_Silent_p.R121R	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	545					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACAGGACCCCGTTCTCCTTGA	0.478			NA											17	102					3.52763e-06	3.92623e-06	0.00499	1	0
Unknown	0	broad.mit.edu	37	2	190788271	190788271	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:190788271G>A	uc002uro.2	+	1	353	c.210G>A	c.(208-210)GAG>GAA	p.E70E						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;												NA						TAGCAGGAGAGGATGGCAGAA	0.478			NA											36	78					0	0	0.004878	0	0
SF3B1	23451	broad.mit.edu	37	2	198265001	198265001	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:198265001G>A	uc002uue.2	-	19	2924	c.2876C>T	c.(2875-2877)GCT>GTT	p.A959V		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	959					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CATGACAACAGCAGTTCGAGA	0.348			NA											42	100					0	0	0.007835	0	0
SATB2	23314	broad.mit.edu	37	2	200298195	200298195	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:200298195C>A	uc002uuy.1	-	3	1029	c.212G>T	c.(211-213)GGC>GTC	p.G71V	SATB2_uc010fsq.1_Missense_Mutation_p.G71V|SATB2_uc002uuz.1_Missense_Mutation_p.G71V|SATB2_uc002uva.1_Missense_Mutation_p.G71V	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	71						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCAAGAGAGCCGTCCAACTG	0.473	Colon(30;262 767 11040 24421 36230)		NA											36	120					4.65686e-17	7.18123e-17	0.003755	1	0
DYTN	391475	broad.mit.edu	37	2	207528121	207528121	+	Splice_Site	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:207528121T>A	uc002vbr.1	-	11	1258	c.1141_splice	c.e11-1	p.A381_splice		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin							plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		CAACCTTGCCTGGGGAAACAA	0.378			NA											12	32					0	0	0.001368	0	0
ACADL	33	broad.mit.edu	37	2	211085421	211085421	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:211085421C>G	uc002vdz.3	-	2	411	c.183G>C	c.(181-183)CGG>CGC	p.R61R	ACADL_uc010zjg.1_Silent_p.R61R	NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	61					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		TTACACTTTTCCGGAAAATGT	0.383			NA											36	92					0	0	0.003755	0	0
ZFAND2B	130617	broad.mit.edu	37	2	220073185	220073185	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:220073185G>A	uc002vka.2	+	6	737	c.565G>A	c.(565-567)GTG>ATG	p.V189M	ZFAND2B_uc010zkt.1_Missense_Mutation_p.V189M|ZFAND2B_uc010fwd.1_3'UTR|ZFAND2B_uc002vjy.1_Missense_Mutation_p.V189M|ZFAND2B_uc002vjz.1_3'UTR|ZFAND2B_uc002vkb.1_Missense_Mutation_p.V80M	NM_138802	NP_620157	Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	189						endoplasmic reticulum	protein binding|zinc ion binding				0		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCCCCTCCAGTGATTGCTTT	0.542			NA											21	151					0	0	0.002299	0	0
WDR69	164781	broad.mit.edu	37	2	228771916	228771916	+	Silent	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:228771916A>T	uc002vpn.1	+	10	1000	c.921A>T	c.(919-921)CTA>CTT	p.L307L	WDR69_uc010zlw.1_Silent_p.L292L|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	307	WD 6.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		ATGAAATACTAGACAGCTGCT	0.353			NA											7	45					0	0	0.004482	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886442	228886442	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:228886442C>A	uc002vpq.2	-	6	729	c.682G>T	c.(682-684)GAT>TAT	p.D228Y	SPHKAP_uc002vpp.2_Missense_Mutation_p.D228Y|SPHKAP_uc010zlx.1_Missense_Mutation_p.D228Y	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	228						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTAGATTCATCCACCTCGCTT	0.443			NA											32	79					3.99451e-17	6.18403e-17	0.009535	1	0
GPR55	9290	broad.mit.edu	37	2	231775240	231775240	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:231775240C>A	uc002vrg.2	-	2	631	c.438G>T	c.(436-438)TGG>TGT	p.W146C	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.W146C	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	146	Helical; Name=4; (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		ACACCAGGACCCAGATGGTGC	0.542			NA											43	98					1.57019e-19	2.53548e-19	0.007835	1	0
C2orf57	165100	broad.mit.edu	37	2	232457748	232457748	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:232457748C>G	uc002vrz.2	+	1	137	c.86C>G	c.(85-87)CCA>CGA	p.P29R		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	29										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		GGTCAGGTCCCACTCACAGCA	0.607			NA											27	137					0	0	0.005443	0	0
CHRNG	1146	broad.mit.edu	37	2	233406159	233406159	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:233406159G>A	uc002vsx.1	+	5	447	c.426G>A	c.(424-426)CCG>CCA	p.P142P	CHRNG_uc010fyd.2_Silent_p.P142P|CHRNG_uc010fye.1_Intron	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	142	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		ACTGGCTGCCGCCTGCCATCT	0.577			NA											20	110					0	0	0.00333	0	0
HJURP	55355	broad.mit.edu	37	2	234750371	234750372	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:234750371_234750372CC>AA	uc002vvg.2	-	8	1120_1121	c.1054_1055GG>TT	c.(1054-1056)GGT>TTT	p.G352F	HJURP_uc010znd.1_Missense_Mutation_p.G291F|HJURP_uc010zne.1_Missense_Mutation_p.G260F	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	352					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		CAATTTTAAACCTGTCTTACGG	0.436			NA											8	79					0	0	0.004672	0	0
PER2	8864	broad.mit.edu	37	2	239164502	239164502	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:239164502C>A	uc002vyc.2	-	18	2353	c.2116G>T	c.(2116-2118)GGC>TGC	p.G706C	PER2_uc010znv.1_Missense_Mutation_p.G706C	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	706	CSNK1E binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AGGGCAGGGCCCGCCAGGCAG	0.587			NA											36	185					2.75727e-19	4.42511e-19	0.004878	1	0
FARP2	9855	broad.mit.edu	37	2	242402803	242402803	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr2:242402803G>T	uc002wbi.1	+	16	1848	c.1731G>T	c.(1729-1731)ACG>ACT	p.T577T	FARP2_uc010zoq.1_Silent_p.T577T|FARP2_uc010zor.1_Silent_p.T577T	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	577	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CTCTGATGACGCTGCTCTTCT	0.597			NA											25	76					4.16121e-05	4.48568e-05	0.00278	1	0
PROKR2	128674	broad.mit.edu	37	20	5294629	5294629	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:5294629G>T	uc010zqw.1	-	1	387	c.387C>A	c.(385-387)GCC>GCA	p.A129A	PROKR2_uc010zqx.1_Silent_p.A129A|PROKR2_uc010zqy.1_Silent_p.A129A|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	129	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AGTTGACGGAGGCACAGAGCA	0.607			NA								HNSCC(71;0.22)			18	44					9.16793e-09	1.0946e-08	0.00499	1	0
SEL1L2	80343	broad.mit.edu	37	20	13912364	13912364	+	Silent	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:13912364T>A	uc010gcf.2	-	3	250	c.168A>T	c.(166-168)ACA>ACT	p.T56T	SEL1L2_uc002woq.3_5'UTR|SEL1L2_uc010zrl.1_Silent_p.T56T|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	56	Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						CATTACTAGATGTTCTTTGTT	0.279			NA											20	56					0	0	0.007413	0	0
C20orf26	26074	broad.mit.edu	37	20	20269349	20269349	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:20269349A>G	uc002wru.2	+	23	2969	c.2893A>G	c.(2893-2895)ACC>GCC	p.T965A	C20orf26_uc002wrw.2_Intron	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	965										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TGTGATTGATACCAACTTCCA	0.433			NA											58	157					0	0	0.00361	0	0
NAPB	63908	broad.mit.edu	37	20	23370621	23370621	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:23370621G>C	uc002wta.2	-	7	640	c.523C>G	c.(523-525)CTT>GTT	p.L175V	NAPB_uc002wtc.2_Missense_Mutation_p.L81V|NAPB_uc002wtb.2_Missense_Mutation_p.L179V|NAPB_uc002wtd.3_RNA|NAPB_uc010zss.1_Missense_Mutation_p.L62V|NAPB_uc010zst.1_Missense_Mutation_p.L136V	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	175					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					TACTGCTCAAGCTGGGCAGCA	0.398			NA											20	104					0	0	0.001882	0	0
AHCY	191	broad.mit.edu	37	20	32878562	32878562	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:32878562G>A	uc002xai.2	-	6	880	c.741C>T	c.(739-741)ATC>ATT	p.I247I	AHCY_uc002xaj.2_Silent_p.I219I	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	247					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0						GCAGTGCGTTGATGGGGTCAA	0.632			NA											67	186					0	0	0.00361	0	0
PLCG1	5335	broad.mit.edu	37	20	39801184	39801184	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:39801184G>T	uc002xjp.1	+	26	3150	c.3029G>T	c.(3028-3030)CGC>CTC	p.R1010L	PLCG1_uc002xjo.1_Missense_Mutation_p.R1010L|PLCG1_uc010zwe.1_Missense_Mutation_p.R636L	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1010	PI-PLC Y-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CAGCTCTCCCGCATCTACCCC	0.542			NA											6	47					0.00116845	0.00122601	0.001168	1	0
LPIN3	64900	broad.mit.edu	37	20	39985681	39985681	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:39985681G>T	uc002xjx.2	+	15	1896	c.1805G>T	c.(1804-1806)CGG>CTG	p.R602L	LPIN3_uc010ggh.2_Missense_Mutation_p.R603L|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	602	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				TGGCCTCAGCGGCGCCTGAAC	0.612			NA											14	62					0.000422831	0.000450258	0.004007	1	0
SGK2	10110	broad.mit.edu	37	20	42199282	42199282	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:42199282G>A	uc002xkv.2	+	6	785	c.566G>A	c.(565-567)CGC>CAC	p.R189H	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.R129H|SGK2_uc010ggm.2_Missense_Mutation_p.R129H|SGK2_uc002xks.2_Missense_Mutation_p.R128H|SGK2_uc002xku.2_Missense_Mutation_p.R129H	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	189	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGCGGGAGCGCCGGTTCCTG	0.637			NA											19	111					0	0	0.008871	0	0
NCOA3	8202	broad.mit.edu	37	20	46268485	46268485	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:46268485A>G	uc002xtk.2	+	15	3077	c.2872A>G	c.(2872-2874)ATT>GTT	p.I958V	NCOA3_uc010ght.1_Missense_Mutation_p.I953V|NCOA3_uc002xtl.2_Missense_Mutation_p.I958V|NCOA3_uc002xtm.2_Missense_Mutation_p.I958V|NCOA3_uc002xtn.2_Missense_Mutation_p.I958V|NCOA3_uc010zyc.1_Missense_Mutation_p.I753V	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	958					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						GGGTGGCTCTATTCCCACATT	0.493			NA											78	179					0	0	0.00361	0	0
SULF2	55959	broad.mit.edu	37	20	46313275	46313275	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:46313275C>A	uc002xto.2	-	6	1118	c.788G>T	c.(787-789)CGC>CTC	p.R263L	SULF2_uc002xtr.2_Missense_Mutation_p.R263L|SULF2_uc002xtq.2_Missense_Mutation_p.R263L	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	263					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCCCGTGTAGCGCATGATCCA	0.597			NA											19	54					1.50039e-11	1.99377e-11	0.001882	1	0
PREX1	57580	broad.mit.edu	37	20	47364417	47364417	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:47364417C>A	uc002xtw.1	-	2	243	c.220G>T	c.(220-222)GCA>TCA	p.A74S		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	74	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGCAGGAATGCCTGGAGGAGA	0.592			NA											7	22					8.12818e-05	8.70246e-05	0.001984	1	0
SLC9A8	23315	broad.mit.edu	37	20	48504417	48504417	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:48504417G>T	uc002xuv.1	+	16	1900	c.1690G>T	c.(1690-1692)GAG>TAG	p.E564*	SLC9A8_uc010zym.1_Nonsense_Mutation_p.E264*|SLC9A8_uc010gid.2_Nonsense_Mutation_p.E188*	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	564						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CAAGTGGTACGAGGAGGTACG	0.657			NA											41	90					4.67007e-22	7.88011e-22	0.00874	1	0
KCNG1	3755	broad.mit.edu	37	20	49626742	49626742	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:49626742C>A	uc002xwa.3	-	2	429	c.134G>T	c.(133-135)CGG>CTG	p.R45L	KCNG1_uc002xwb.2_Missense_Mutation_p.R45L	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	45	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CGGCCGCAGCCGCTGCGCCCG	0.706			NA											16	21					5.03518e-11	6.56908e-11	0.007413	1	0
SALL4	57167	broad.mit.edu	37	20	50407691	50407691	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:50407691T>A	uc002xwh.3	-	2	1432	c.1331A>T	c.(1330-1332)GAG>GTG	p.E444V	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	444					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTCCTGGAACTCGGCAAACAG	0.552			NA											47	77					0	0	0.00361	0	0
CTCFL	140690	broad.mit.edu	37	20	56078492	56078492	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:56078492C>A	uc010gix.1	-	9	2502	c.1840G>T	c.(1840-1842)GAA>TAA	p.E614*	CTCFL_uc010giw.1_Nonsense_Mutation_p.E614*|CTCFL_uc002xym.2_Nonsense_Mutation_p.E614*|CTCFL_uc010giz.1_Nonsense_Mutation_p.E202*|CTCFL_uc010giy.1_Nonsense_Mutation_p.E284*|CTCFL_uc010gja.1_Nonsense_Mutation_p.E564*|CTCFL_uc010gjb.1_Nonsense_Mutation_p.E614*|CTCFL_uc010gjc.1_Nonsense_Mutation_p.E614*|CTCFL_uc010gjd.1_Nonsense_Mutation_p.E614*|CTCFL_uc010gje.2_Missense_Mutation_p.G614C|CTCFL_uc010gjf.2_Missense_Mutation_p.G409C|CTCFL_uc010gjg.2_Missense_Mutation_p.G346C|CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_RNA	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	614					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AAATCAGTACCGTCTCCGTTC	0.512			NA											56	134					8.72158e-25	1.53065e-24	0.00361	1	0
PMEPA1	56937	broad.mit.edu	37	20	56227123	56227123	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:56227123C>T	uc002xyq.2	-	4	1243	c.850G>A	c.(850-852)GGA>AGA	p.G284R	PMEPA1_uc002xyr.2_Missense_Mutation_p.G234R|PMEPA1_uc002xys.2_Missense_Mutation_p.G249R|PMEPA1_uc002xyt.2_Missense_Mutation_p.G234R	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	284	Cytoplasmic (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						AGAGGGTGTCCTTTCTGTTTA	0.627			NA											3	12					0	0	0.004672	0	0
CDH26	60437	broad.mit.edu	37	20	58567503	58567503	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:58567503G>T	uc002ybe.2	+	10	1654	c.1354G>T	c.(1354-1356)GAG>TAG	p.E452*	CDH26_uc002ybf.1_Nonsense_Mutation_p.E32*|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_5'Flank	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	452	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CATCACCGTGGAGCCAATTGA	0.413			NA											14	72					4.14922e-12	5.66652e-12	0.004007	1	0
LAMA5	3911	broad.mit.edu	37	20	60888802	60888802	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:60888802G>C	uc002ycq.2	-	63	8628	c.8561C>G	c.(8560-8562)ACC>AGC	p.T2854S		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2854	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCACCCTTGGTTTCCTGGAT	0.507			NA											51	126					0	0	0.00361	0	0
NTSR1	4923	broad.mit.edu	37	20	61386223	61386223	+	Missense_Mutation	SNP	G	G	T	rs148569146	byFrequency	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:61386223G>T	uc002ydf.2	+	2	1272	c.901G>T	c.(901-903)GGC>TGC	p.G301C		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	301	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CCTGCGGCACGGCGTGCGCGT	0.706	GBM(37;400 780 6403 19663 35669)		NA											18	32					1.67942e-08	1.99004e-08	0.006122	1	0
COL9A3	1299	broad.mit.edu	37	20	61453144	61453144	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:61453144C>A	uc002ydm.2	+	8	408	c.405C>A	c.(403-405)ATC>ATA	p.I135I		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	135	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CAGGTGGGATCGGCCTCCGCG	0.697			NA											6	29					0.00116845	0.00122601	0.001168	1	0
CHRNA4	1137	broad.mit.edu	37	20	61982276	61982276	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:61982276T>C	uc002yes.2	-	5	665	c.487A>G	c.(487-489)ATC>GTC	p.I163V	CHRNA4_uc002yet.1_5'UTR|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.I92V|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	163	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GTGACGTCGATGCTGCAGGAG	0.597			NA											27	137					0	0	0.004656	0	0
KCNQ2	3785	broad.mit.edu	37	20	62044883	62044883	+	Silent	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:62044883G>C	uc002yey.1	-	15	1860	c.1683C>G	c.(1681-1683)CCC>CCG	p.P561P	KCNQ2_uc002yez.1_Silent_p.P530P|KCNQ2_uc002yfa.1_Silent_p.P543P|KCNQ2_uc002yfb.1_Silent_p.P533P	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	561	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TCACGTCGTAGGGCCGCAGGC	0.652			NA											63	169					0	0	0.00361	0	0
KCNQ2	3785	broad.mit.edu	37	20	62073809	62073809	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:62073809C>A	uc002yey.1	-	5	943	c.766G>T	c.(766-768)GGG>TGG	p.G256W	KCNQ2_uc002yez.1_Missense_Mutation_p.G256W|KCNQ2_uc002yfa.1_Missense_Mutation_p.G256W|KCNQ2_uc002yfb.1_Missense_Mutation_p.G256W|KCNQ2_uc011aax.1_Missense_Mutation_p.G256W|KCNQ2_uc002yfc.1_Missense_Mutation_p.G256W	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	256	Extracellular (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TCGTTCTCCCCCTTCTCTGCC	0.572			NA											117	300					9.93988e-36	1.93877e-35	0.00361	1	0
MRPL39	54148	broad.mit.edu	37	21	26969716	26969716	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:26969716C>A	uc002ylo.2	-	6	613	c.599G>T	c.(598-600)CGT>CTT	p.R200L	MRPL39_uc002yln.2_Missense_Mutation_p.R200L	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	200						mitochondrial ribosome	nucleotide binding				0						TGTGAAGGAACGTAAGTTCTC	0.328			NA											10	15					4.68919e-08	5.47419e-08	0.008291	1	0
JAM2	58494	broad.mit.edu	37	21	27062220	27062220	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:27062220C>A	uc002ylp.1	+	3	721	c.176C>A	c.(175-177)TCC>TAC	p.S59Y	JAM2_uc011ace.1_Missense_Mutation_p.S59Y|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Intron|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.S59Y|JAM2_uc010gli.1_Missense_Mutation_p.S59Y	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	59	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						ACTGTTTCCTCCAGATTAGAG	0.403			NA											43	170					5.48756e-27	9.89519e-27	0.002852	1	0
ADAMTS1	9510	broad.mit.edu	37	21	28209990	28209990	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:28209990G>A	uc002ymf.2	-	9	3267	c.2812C>T	c.(2812-2814)CAT>TAT	p.H938Y		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	938	TSP type-1 3.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		CCTCCATCATGGGACAGACAC	0.458			NA											34	129					0	0	0.002096	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296585	28296585	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:28296585G>A	uc002ymg.2	-	8	3309	c.2580C>T	c.(2578-2580)AAC>AAT	p.N860N		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	860	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TAGTGACAGAGTTTACTTTTG	0.483	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											47	128					0	0	0.002522	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768509	31768509	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:31768509C>T	uc002yoa.2	+	1	118	c.105C>T	c.(103-105)GTC>GTT	p.V35V		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	35						intermediate filament				ovary(1)	1						GCAACCAGGTCTACAGCACTG	0.602			NA											42	133					0	0	0.009718	0	0
KRTAP19-6	337973	broad.mit.edu	37	21	31914063	31914063	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:31914063G>T	uc002yok.1	-	1	119	c.90C>A	c.(88-90)TAC>TAA	p.Y30*		NM_181612	NP_853643	Q3LI70	KR196_HUMAN	keratin associated protein 19-6	30						intermediate filament					0						AGCCATATCTGTAGCCTCCAC	0.512			NA											39	116					5.82218e-30	1.08976e-29	0.00361	1	0
TIAM1	7074	broad.mit.edu	37	21	32525054	32525054	+	Missense_Mutation	SNP	G	G	A	rs148623159		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:32525054G>A	uc002yow.1	-	20	3738	c.3266C>T	c.(3265-3267)ACG>ATG	p.T1089M	TIAM1_uc011adk.1_Missense_Mutation_p.T1089M|TIAM1_uc011adl.1_Missense_Mutation_p.T1029M	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1089	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TACCATTTCCGTTAAATTTCC	0.333			NA											7	55					0	0	0.001984	0	0
PCBP3	54039	broad.mit.edu	37	21	47360037	47360037	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr21:47360037G>A	uc002zhq.1	+	13	1128	c.1003G>A	c.(1003-1005)GGG>AGG	p.G335R	PCBP3_uc002zhp.1_Missense_Mutation_p.G315R|PCBP3_uc002zhs.1_Missense_Mutation_p.G309R|PCBP3_uc002zhr.1_Missense_Mutation_p.G334R|PCBP3_uc002zht.1_Missense_Mutation_p.G325R	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	335	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CGCCACGGAAGGGTCCTCAGA	0.527			NA											44	85					0	0	0.002522	0	0
KLHL22	84861	broad.mit.edu	37	22	20812279	20812279	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr22:20812279G>A	uc002zsl.1	-	5	1230	c.1121C>T	c.(1120-1122)CCA>CTA	p.P374L	KLHL22_uc011ahr.1_Missense_Mutation_p.P231L|KLHL22_uc002zsm.1_Missense_Mutation_p.P374L	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	374	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GTTGTGCCGTGGGTCATACCT	0.597			NA											17	29					0	0	0.00499	0	0
PIWIL3	440822	broad.mit.edu	37	22	25145401	25145401	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr22:25145401G>A	uc003abd.1	-	11	1721	c.1304C>T	c.(1303-1305)ACA>ATA	p.T435I	PIWIL3_uc011ajx.1_Missense_Mutation_p.T326I|PIWIL3_uc011ajy.1_Missense_Mutation_p.T326I|PIWIL3_uc010gut.1_Missense_Mutation_p.T435I	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	435					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TTCTTTTAATGTATGATGCCT	0.363			NA											21	86					0	0	0.001882	0	0
CHL1	10752	broad.mit.edu	37	3	382518	382518	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:382518G>T	uc003bou.2	+	6	698	c.427G>T	c.(427-429)GTG>TTG	p.V143L	CHL1_uc003bot.2_Missense_Mutation_p.V143L|CHL1_uc003bow.1_Missense_Mutation_p.V143L|CHL1_uc011asi.1_Missense_Mutation_p.V143L	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	143	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CCCTCTTGAAGTGGAGGAGGG	0.368			NA											19	41					1.56452e-12	2.17817e-12	0.007413	1	0
ITPR1	3708	broad.mit.edu	37	3	4718485	4718485	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:4718485G>T	uc003bqa.2	+	24	3288	c.2940G>T	c.(2938-2940)CAG>CAT	p.Q980H	ITPR1_uc010hca.1_Missense_Mutation_p.Q965H|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.Q974H	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	989	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATACTCCAGGTATCCACTA	0.547			NA											9	26					0.000274275	0.000292461	0.004482	1	0
TBC1D5	9779	broad.mit.edu	37	3	17208408	17208408	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:17208408G>T	uc003cbf.2	-	21	3610	c.1945C>A	c.(1945-1947)CTA>ATA	p.L649I	TBC1D5_uc010heu.2_Missense_Mutation_p.L236I|TBC1D5_uc010hev.2_Missense_Mutation_p.L671I|TBC1D5_uc003cbe.2_Missense_Mutation_p.L649I	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	649						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GAACCTTTTAGAATGTCTTTG	0.423			NA											17	31					1.15088e-07	1.32393e-07	0.004007	1	0
TRAK1	22906	broad.mit.edu	37	3	42166916	42166916	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:42166916G>T	uc003cky.2	+	2	312	c.96G>T	c.(94-96)GTG>GTT	p.V32V	TRAK1_uc011azh.1_Silent_p.V32V|TRAK1_uc011azi.1_Silent_p.V32V	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	32					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						CTTTAGATGTGTGCAACAGCA	0.488	GBM(44;195 884 22595 31865 41850)		NA											18	35					0.00074312	0.000786012	0.006122	1	0
CCDC13	152206	broad.mit.edu	37	3	42799619	42799619	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:42799619C>A	uc003cly.3	-	2	303	c.219G>T	c.(217-219)AAG>AAT	p.K73N	CCDC13_uc003clz.2_Missense_Mutation_p.K73N|CCDC13_uc011azq.1_Missense_Mutation_p.K73N	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	73	Potential.									ovary(1)	1						GCATTTACCTCTTCTCAAAGC	0.363			NA											20	43					3.51602e-12	4.85223e-12	0.008871	1	0
DHX30	22907	broad.mit.edu	37	3	47882439	47882439	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:47882439G>T	uc003cru.2	+	7	865	c.439G>T	c.(439-441)GGC>TGC	p.G147C	DHX30_uc003crs.2_Missense_Mutation_p.G108C|DHX30_uc003crt.2_Missense_Mutation_p.G108C|DHX30_uc010hjr.1_Missense_Mutation_p.G175C	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	147						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGATCGCTTTGGCTCCCCTGC	0.602			NA											30	43					1.88708e-17	2.9622e-17	0.008361	1	0
GBE1	2632	broad.mit.edu	37	3	81586172	81586172	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:81586172G>A	uc003dqg.2	-	14	1976	c.1693C>T	c.(1693-1695)CGG>TGG	p.R565W	GBE1_uc011bgm.1_Missense_Mutation_p.R524W	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	565					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TGAAACTGCCGCCTGGCATAA	0.383			NA							Glycogen_Storage_Disease_type_IV				14	33					0	0	0.001855	0	0
EPHA3	2042	broad.mit.edu	37	3	89480412	89480412	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:89480412G>T	uc003dqy.2	+	13	2474	c.2249G>T	c.(2248-2250)CGG>CTG	p.R750L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	750	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTCGCTGCTCGGAACATCTTG	0.488			NA								TSP Lung(6;0.00050)			19	36					1.67942e-08	1.99004e-08	0.006122	1	0
OR5H1	26341	broad.mit.edu	37	3	97851886	97851886	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:97851886G>T	uc011bgt.1	+	1	345	c.345G>T	c.(343-345)TTG>TTT	p.L115F		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GTTTTCTCTTGGCAACGATGG	0.383			NA											67	217					2.3441e-25	4.16025e-25	0.00361	1	0
ST3GAL6	10402	broad.mit.edu	37	3	98503797	98503797	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:98503797G>T	uc003dsz.2	+	6	580	c.344G>T	c.(343-345)TGT>TTT	p.C115F	ST3GAL6_uc003dsy.2_Missense_Mutation_p.C29F|ST3GAL6_uc003dta.2_Intron|ST3GAL6_uc003dtb.2_5'UTR|ST3GAL6_uc003dtc.2_Missense_Mutation_p.C115F|ST3GAL6_uc010hpd.2_Missense_Mutation_p.C168F	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	115	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						AGCATACCCTGTAAAAAGTGT	0.368			NA											30	83					2.2171e-23	3.80627e-23	0.009535	1	0
TBC1D23	55773	broad.mit.edu	37	3	100002603	100002603	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:100002603C>A	uc003dtt.2	+	4	601	c.424C>A	c.(424-426)CGC>AGC	p.R142S	TBC1D23_uc003dts.2_Missense_Mutation_p.R142S	NM_018309	NP_060779	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	142	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2						TCAACTGCCACGCAGCGATTT	0.338			NA											15	93					1.67942e-08	1.99004e-08	0.006122	1	0
ALCAM	214	broad.mit.edu	37	3	105271017	105271017	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:105271017G>C	uc003dvx.2	+	13	2077	c.1537G>C	c.(1537-1539)GAG>CAG	p.E513Q	ALCAM_uc003dvw.1_Missense_Mutation_p.E513Q|ALCAM_uc003dvy.2_Intron|ALCAM_uc010hpp.2_Missense_Mutation_p.E235Q|ALCAM_uc003dvz.2_Missense_Mutation_p.E147Q	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	513	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						TGAGGCAGACGAGATAAGTGG	0.338			NA											11	50					0	0	0.001368	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432892	111432892	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:111432892T>G	uc003dya.2	+	3	1369	c.783T>G	c.(781-783)CAT>CAG	p.H261Q	PLCXD2_uc003dyb.2_Missense_Mutation_p.H261Q|PLCXD2_uc003dxz.2_Missense_Mutation_p.H261Q	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	261					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						GCTCCTTCCATGTCTCCCAAG	0.562			NA											25	110					0	0	0.005443	0	0
SLC9A10	285335	broad.mit.edu	37	3	111870801	111870801	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:111870801G>T	uc003dyu.2	-	28	3649	c.3427C>A	c.(3427-3429)CAC>AAC	p.H1143N	SLC9A10_uc011bhu.1_Missense_Mutation_p.H406N|SLC9A10_uc010hqc.2_Missense_Mutation_p.H1095N	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1143					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						GCGGCACTGTGTGCTCCATCC	0.383			NA											25	73					9.57634e-11	1.23707e-10	0.00333	1	0
FSTL1	11167	broad.mit.edu	37	3	120129820	120129820	+	Missense_Mutation	SNP	C	C	T	rs149509930		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:120129820C>T	uc003eds.2	-	5	485	c.310G>A	c.(310-312)GTA>ATA	p.V104I	FSTL1_uc011bjh.1_Missense_Mutation_p.V69I|FSTL1_uc010hrb.2_Missense_Mutation_p.V104I	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	104					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		GATGGACTTACGGATTTCTTC	0.393			NA											5	122					0	0	0.000602	0	0
SEMA5B	54437	broad.mit.edu	37	3	122631817	122631817	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:122631817G>T	uc003efz.1	-	18	2902	c.2598C>A	c.(2596-2598)TCC>TCA	p.S866S	SEMA5B_uc011bju.1_Silent_p.S808S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.S866S|SEMA5B_uc003efy.1_5'Flank	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	866	Extracellular (Potential).|TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CGCAGTCCCGGGAGCAGGACG	0.741			NA											7	33					0.00307968	0.00318894	0.00308	1	0
MUC13	56667	broad.mit.edu	37	3	124646418	124646418	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:124646418C>A	uc003ehq.1	-	2	496	c.472G>T	c.(472-474)GGC>TGC	p.G158C		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	158	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						AAAGCGGTGCCAGTGGGAGGC	0.473			NA											65	219					1.84395e-34	3.55265e-34	0.00361	1	0
ZXDC	79364	broad.mit.edu	37	3	126180702	126180702	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:126180702C>A	uc003eiv.2	-	6	1857	c.1803G>T	c.(1801-1803)GTG>GTT	p.V601V	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Silent_p.V601V	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	601	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TCACAGTCTGCACGTCATCCA	0.567			NA											54	157					3.31993e-32	6.33439e-32	0.00361	1	0
UROC1	131669	broad.mit.edu	37	3	126224636	126224636	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:126224636C>T	uc003eiz.1	-	8	753	c.721G>A	c.(721-723)GGG>AGG	p.G241R	UROC1_uc010hsi.1_Missense_Mutation_p.G241R	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	241					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		AAGACCTTCCCAGCCAAGTCC	0.637			NA											16	67					0	0	0.008871	0	0
MCM2	4171	broad.mit.edu	37	3	127324962	127324962	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:127324962G>T	uc003ejp.2	+	5	732	c.675G>T	c.(673-675)GAG>GAT	p.E225D	MCM2_uc011bkm.1_Missense_Mutation_p.E95D|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.E109D	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	225	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CCCTTCTAGAGAACCGTGAGA	0.602			NA											29	83					7.01153e-11	9.08732e-11	0.007291	1	0
COL6A6	131873	broad.mit.edu	37	3	130313158	130313158	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:130313158C>A	uc010htl.2	+	17	4535	c.4504C>A	c.(4504-4506)CGT>AGT	p.R1502S	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1502	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCCTGGTGACCGTGGAGCAAA	0.463			NA											29	101					3.73148e-12	5.12265e-12	0.007291	1	0
PIK3R4	30849	broad.mit.edu	37	3	130425910	130425910	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:130425910G>A	uc003enj.2	-	11	3184	c.2603C>T	c.(2602-2604)CCA>CTA	p.P868L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	868					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CATGTTTGGTGGGTCCAGTGA	0.443			NA											15	52					0	0	0.004007	0	0
CEP63	80254	broad.mit.edu	37	3	134278166	134278166	+	Silent	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:134278166T>C	uc003eqo.1	+	15	2297	c.1848T>C	c.(1846-1848)TCT>TCC	p.S616S	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	616					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						CTTCCTACTCTCTATGTAAAA	0.438			NA											74	220					0	0	0.00361	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142537297	142537297	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:142537297G>T	uc003evd.2	-	9	1324	c.1128C>A	c.(1126-1128)TAC>TAA	p.Y376*		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	376	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CCATAATAATGTAATTTAGAC	0.363			NA											40	102					3.61848e-18	5.72562e-18	0.007835	1	0
SR140	23350	broad.mit.edu	37	3	142747463	142747463	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:142747463A>T	uc003evh.1	+	16	1684	c.1585A>T	c.(1585-1587)AGT>TGT	p.S529C	SR140_uc003evi.1_Missense_Mutation_p.S120C|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.S528C|SR140_uc003evl.1_Missense_Mutation_p.S96C	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	529					RNA processing	nucleus	nucleotide binding|RNA binding				0						AGAGGAACCTAGTAAAAAGGG	0.333	Colon(87;897 1320 15089 19747 35974)		NA											24	55					0	0	0.00278	0	0
CHST2	9435	broad.mit.edu	37	3	142841221	142841221	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:142841221C>A	uc003evm.2	+	2	2452	c.1563C>A	c.(1561-1563)AGC>AGA	p.S521R		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	521	Lumenal (Potential).			S->A: No effect.	inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						AAGACCTCAGCAAGACCCTGC	0.527			NA											13	37					2.61681e-11	3.43103e-11	0.00245	1	0
HPS3	84343	broad.mit.edu	37	3	148863150	148863150	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:148863150C>G	uc003ewu.1	+	5	1120	c.980C>G	c.(979-981)ACA>AGA	p.T327R	HPS3_uc003ewt.1_Missense_Mutation_p.T327R|HPS3_uc011bnq.1_Missense_Mutation_p.T162R	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	327						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GGTTCTCTTACATCTGATGGA	0.259			NA							Hermansky-Pudlak_syndrome				24	87					0	0	0.003954	0	0
MED12L	116931	broad.mit.edu	37	3	151134112	151134112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:151134112C>T	uc003eyp.2	+	41	6243	c.6205C>T	c.(6205-6207)CAG>TAG	p.Q2069*	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2069	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			Gcagcagccccagcagcccca	0.343			NA											22	41					0	0	0.002299	0	0
ZBBX	79740	broad.mit.edu	37	3	167031857	167031857	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:167031857C>A	uc003fep.2	-	16	1645	c.1322G>T	c.(1321-1323)GGC>GTC	p.G441V	ZBBX_uc011bpc.1_Missense_Mutation_p.G441V|ZBBX_uc003feq.2_Missense_Mutation_p.G412V	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	441						intracellular	zinc ion binding			ovary(2)	2						TTGATGGATGCCATTTTCATA	0.299			NA											23	108					6.44725e-10	7.9881e-10	0.002299	1	0
GHSR	2693	broad.mit.edu	37	3	172163026	172163026	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:172163026G>T	uc003fib.1	-	2	1026	c.1026C>A	c.(1024-1026)CCC>CCA	p.P342P		NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	342	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TCTGGGAGAAGGGTTCGAATC	0.478	Esophageal Squamous(93;641 1401 20883 29581 34638)		NA											59	199					2.47907e-22	4.19207e-22	0.00361	1	0
NLGN1	22871	broad.mit.edu	37	3	173525608	173525608	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:173525608G>T	uc003fio.1	+	4	1055	c.632G>T	c.(631-633)CGA>CTA	p.R211L	NLGN1_uc010hww.1_Missense_Mutation_p.R251L|NLGN1_uc003fip.1_Missense_Mutation_p.R211L	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	228	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTCAACTATCGACTTGGAGTA	0.328			NA											39	89					2.59497e-14	3.75889e-14	0.007835	1	0
KLHL6	89857	broad.mit.edu	37	3	183225911	183225911	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:183225911C>A	uc003flr.2	-	3	903	c.845G>T	c.(844-846)AGG>ATG	p.R282M	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Missense_Mutation_p.R280M	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	282										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TGGGCACTGCCTGATGAGAGG	0.537			NA											37	139					1.08052e-11	1.44804e-11	0.004289	1	0
CHRD	8646	broad.mit.edu	37	3	184104632	184104632	+	Splice_Site	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:184104632G>T	uc003fov.2	+	17	2443	c.2197_splice	c.e17-1	p.R733_splice	CHRD_uc003fow.2_Splice_Site_p.R363_splice|CHRD_uc003fox.2_Splice_Site_p.R733_splice|CHRD_uc003foy.2_Splice_Site_p.R363_splice|CHRD_uc010hyc.2_Splice_Site_p.R323_splice|CHRD_uc011brr.1_Splice_Site_p.R275_splice	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTCTCTGCAGAGACGAACGG	0.652			NA											15	71					2.23348e-06	2.49643e-06	0.004007	1	0
MAGEF1	64110	broad.mit.edu	37	3	184429233	184429233	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:184429233C>A	uc003fpa.2	-	1	604	c.377G>T	c.(376-378)CGG>CTG	p.R126L		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	126	MAGE.									ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			AAAGACATACCGCAGATGCTC	0.418			NA											35	158					2.09667e-21	3.52276e-21	0.003755	1	0
DGKG	1608	broad.mit.edu	37	3	185986600	185986600	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:185986600C>G	uc003fqa.2	-	12	1643	c.1106G>C	c.(1105-1107)TGC>TCC	p.C369S	DGKG_uc003fqb.2_Intron|DGKG_uc003fqc.2_Missense_Mutation_p.C369S|DGKG_uc011brx.1_Intron	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	369	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CGTCATCCGGCACCACACGCA	0.607			NA											14	44					0	0	0.003163	0	0
RTP2	344892	broad.mit.edu	37	3	187416442	187416442	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:187416442C>T	uc003fro.1	-	2	951	c.522G>A	c.(520-522)GAG>GAA	p.E174E		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	174	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		TGGTCACCTCCTCCTCCAGCA	0.647			NA											21	62					0	0	0.002299	0	0
TPRG1	285386	broad.mit.edu	37	3	188925302	188925302	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr3:188925302G>T	uc003frv.1	+	7	1356	c.129G>T	c.(127-129)AGG>AGT	p.R43S	TPRG1_uc003frw.1_Missense_Mutation_p.R43S	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	43											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		AGATTTCAAGGCAGTCAAGTG	0.473			NA											39	128					9.85521e-28	1.80183e-27	0.00623	1	0
FGFRL1	53834	broad.mit.edu	37	4	1018108	1018108	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:1018108G>T	uc003gce.2	+	6	889	c.728G>T	c.(727-729)CGT>CTT	p.R243L	FGFRL1_uc003gcf.2_Missense_Mutation_p.R243L|FGFRL1_uc003gcg.2_Missense_Mutation_p.R243L|FGFRL1_uc010ibo.2_Missense_Mutation_p.R243L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	243	Extracellular (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GAGCGGACCCGTTCCAAGCCC	0.711			NA											19	71					2.94398e-08	3.44704e-08	0.007413	1	0
DRD5	1816	broad.mit.edu	37	4	9784629	9784629	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:9784629C>A	uc003gmb.3	+	1	1372	c.976C>A	c.(976-978)CCC>ACC	p.P326T		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	326	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAGTGGACACCCCGAAGGCCC	0.587			NA											64	209					1.1794e-34	2.28347e-34	0.00361	1	0
SLC2A9	56606	broad.mit.edu	37	4	10027563	10027563	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:10027563C>A	uc003gmd.2	-	2	187	c.28G>T	c.(28-30)GAA>TAA	p.E10*		NM_001001290	NP_001001290	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	Error:Variant_position_missing_in_Q9NRM0_after_alignment					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						TCTTCATCTTCTCCTCGGTCC	0.393			NA											25	82					2.65835e-16	4.02068e-16	0.007291	1	0
RFC1	5981	broad.mit.edu	37	4	39314400	39314400	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:39314400C>A	uc003gty.1	-	11	1489	c.1355G>T	c.(1354-1356)CGT>CTT	p.R452L	RFC1_uc003gtx.1_Missense_Mutation_p.R452L	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	452	BRCT.				DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding	p.R452C(1)		ovary(2)|pancreas(1)|skin(1)	4						TCCACTATCACGACCCATGAC	0.453	Colon(109;59 1555 12203 17579 39824)|Esophageal Squamous(18;360 542 16186 28570 51157)		NA											103	273					1.47424e-42	2.93359e-42	0.00361	1	0
KCTD8	386617	broad.mit.edu	37	4	44449622	44449622	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:44449622C>A	uc003gwu.2	-	1	1203	c.919G>T	c.(919-921)GAC>TAC	p.D307Y		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	307						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ATCTTGTCGTCGCGGTACTGG	0.632			NA								HNSCC(17;0.042)			5	33					0.00116845	0.00122601	0.001168	1	0
CORIN	10699	broad.mit.edu	37	4	47685848	47685848	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:47685848G>A	uc003gxm.2	-	7	1014	c.921C>T	c.(919-921)AGC>AGT	p.S307S	CORIN_uc011bzf.1_Silent_p.S168S|CORIN_uc011bzg.1_Silent_p.S240S|CORIN_uc011bzh.1_Silent_p.S307S|CORIN_uc011bzi.1_Silent_p.S307S|CORIN_uc003gxn.3_Silent_p.S307S	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	307	Extracellular (Potential).|LDL-receptor class A 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						ACAGATTCTCGCTGCAGTCTG	0.398			NA											14	57					0	0	0.001855	0	0
CNGA1	1259	broad.mit.edu	37	4	47939673	47939673	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:47939673G>C	uc003gxt.3	-	11	1104	c.838C>G	c.(838-840)CGT>GGT	p.R280G	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.R349G	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	280	Extracellular (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						TCAAACATACGAGAGAACCGT	0.363			NA											36	95					0	0	0.003755	0	0
FRYL	285527	broad.mit.edu	37	4	48584628	48584628	+	Silent	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:48584628A>T	uc003gyh.1	-	20	2477	c.1872T>A	c.(1870-1872)CGT>CGA	p.R624R	FRYL_uc003gyk.2_Silent_p.R624R	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	624					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CAGTCACTTCACGAACAATAA	0.393			NA											16	54					0	0	0.004007	0	0
EPHA5	2044	broad.mit.edu	37	4	66535351	66535351	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:66535351C>T	uc003hcy.2	-	1	303	c.110G>A	c.(109-111)CGG>CAG	p.R37Q	EPHA5_uc003hcx.2_5'Flank|EPHA5_uc003hcz.2_Missense_Mutation_p.R37Q|EPHA5_uc011cah.1_Missense_Mutation_p.R37Q|EPHA5_uc011cai.1_Missense_Mutation_p.R37Q|EPHA5_uc003hda.2_Missense_Mutation_p.R37Q|uc003hdb.2_5'Flank	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	37	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GAGGGGAGCCCGTCGAGGTGC	0.592			NA								TSP Lung(17;0.13)			4	15					0	0	0.000602	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69100244	69100244	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:69100244G>T	uc003hdw.3	-	5	542	c.406C>A	c.(406-408)CAT>AAT	p.H136N		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	136	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AACATCTGATGTAATTTAGCC	0.378			NA											37	119					3.76114e-14	5.42816e-14	0.004289	1	0
UGT2B4	7363	broad.mit.edu	37	4	70346378	70346378	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:70346378T>C	uc003hek.3	-	6	1608	c.1561A>G	c.(1561-1563)ACA>GCA	p.T521A	UGT2B4_uc011cap.1_Missense_Mutation_p.T385A|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	521					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TTCTTTCCTGTTCTAACAAAC	0.418			NA											53	164					0	0	0.00361	0	0
ALB	213	broad.mit.edu	37	4	74283925	74283925	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:74283925G>C	uc003hgs.3	+	12	1622	c.1549G>C	c.(1549-1551)GTC>CTC	p.V517L	ALB_uc003hgw.3_Missense_Mutation_p.V325L|ALB_uc011cbe.1_Missense_Mutation_p.V196L|ALB_uc003hgt.3_Missense_Mutation_p.V517L|ALB_uc010iii.2_Missense_Mutation_p.V402L|ALB_uc003hgu.3_Missense_Mutation_p.V367L|ALB_uc003hgv.3_Missense_Mutation_p.V196L|ALB_uc011cbf.1_Missense_Mutation_p.V407L|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.V196L	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	517	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AGCTCTGGAAGTCGATGAAAC	0.428			NA											42	128					0	0	0.002852	0	0
CXCL6	6372	broad.mit.edu	37	4	74702735	74702735	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:74702735C>T	uc003hhf.2	+	2	359	c.164C>T	c.(163-165)ACG>ATG	p.T55M	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	55					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TTACGCGTTACGCTGAGAGTA	0.527			NA											37	96					0	0	0.004289	0	0
NAA11	84779	broad.mit.edu	37	4	80246771	80246771	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:80246771G>T	uc003hlt.3	-	1	401	c.261C>A	c.(259-261)GCC>GCA	p.A87A		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	87	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						TCAGCTTCTGGGCCAGGCCGA	0.577			NA											30	102					7.26314e-15	1.06779e-14	0.007291	1	0
TMEM150C	441027	broad.mit.edu	37	4	83417293	83417293	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:83417293C>T	uc003hmy.1	-	6	369	c.291G>A	c.(289-291)CCG>CCA	p.P97P	TMEM150C_uc011ccj.1_Silent_p.P127P	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	97						integral to membrane				ovary(1)	1						TATTCAGCCACGGGTTTAAAA	0.423			NA											32	90					0	0	0.002836	0	0
PTPN13	5783	broad.mit.edu	37	4	87701591	87701591	+	Silent	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:87701591T>G	uc003hpz.2	+	36	6408	c.5928T>G	c.(5926-5928)TCT>TCG	p.S1976S	PTPN13_uc003hpy.2_Silent_p.S1981S|PTPN13_uc003hqa.2_Silent_p.S1957S|PTPN13_uc003hqb.2_Silent_p.S1785S|PTPN13_uc003hqc.1_Silent_p.S342S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1976						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CAAAGAGGTCTGCTGTTTCAG	0.199			NA											4	25					0	0	0.000602	0	0
FAM13A	10144	broad.mit.edu	37	4	89772323	89772323	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:89772323G>A	uc003hse.1	-	7	1063	c.855C>T	c.(853-855)TCC>TCT	p.S285S	FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsh.1_Silent_p.S99S	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	285					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						CCTCACTCCTGGATTTTGGGA	0.408			NA											46	169					0	0	0.003214	0	0
TIGD2	166815	broad.mit.edu	37	4	90034726	90034726	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:90034726G>T	uc003hsk.2	+	1	759	c.601G>T	c.(601-603)GGG>TGG	p.G201W	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	201	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		AAGTACTTCTGGGTGTAGGTC	0.294			NA											38	82					1.07637e-12	1.50921e-12	0.004878	1	0
MMRN1	22915	broad.mit.edu	37	4	90857151	90857151	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:90857151A>T	uc003hst.2	+	6	2391	c.2320A>T	c.(2320-2322)ACA>TCA	p.T774S	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.T516S	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	774					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AACTATTTTGACATTTATTCC	0.353			NA											25	74					0	0	0.00333	0	0
ADH1B	125	broad.mit.edu	37	4	100235229	100235229	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:100235229C>A	uc003hus.3	-	6	661	c.577G>T	c.(577-579)GGC>TGC	p.G193C	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.G153C|ADH1B_uc011ceh.1_Missense_Mutation_p.G38C|ADH1B_uc011cei.1_Missense_Mutation_p.G153C	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	193					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	CAGGTAGAGCCTGGGGTGACC	0.468			NA											65	240					4.13886e-29	7.65592e-29	0.00361	1	0
MANBA	4126	broad.mit.edu	37	4	103553402	103553402	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:103553402C>T	uc003hwg.2	-	17	2552	c.2452G>A	c.(2452-2454)GAC>AAC	p.D818N	MANBA_uc011ces.1_Missense_Mutation_p.D761N	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	818					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GTCTCCAGGTCAAAAACAAAT	0.418			NA											34	113					0	0	0.002096	0	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406403	106406403	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:106406403C>A	uc003hxt.1	+	1	541	c.411C>A	c.(409-411)ACC>ACA	p.T137T		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						GCCACAACACCGACACAGTAG	0.448			NA											15	63					1.05317e-09	1.29875e-09	0.00245	1	0
NDST3	9348	broad.mit.edu	37	4	119064823	119064823	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:119064823C>A	uc003ibx.2	+	6	1926	c.1523C>A	c.(1522-1524)ACT>AAT	p.T508N	NDST3_uc011cgf.1_Missense_Mutation_p.T427N	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	508	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CTTTTCTTCACTGTCGTCCTC	0.428			NA											36	76					2.42023e-17	3.76906e-17	0.003271	1	0
MMAA	166785	broad.mit.edu	37	4	146576326	146576326	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:146576326G>T	uc003ikh.3	+	7	1082	c.997G>T	c.(997-999)GAG>TAG	p.E333*	MMAA_uc010iow.2_RNA	NM_172250	NP_758454	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria type A precursor	333						mitochondrion	GTP binding|nucleoside-triphosphatase activity			ovary(1)	1	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCGAAGTGGAGAGGGGATCTC	0.423			NA											28	108					4.87955e-14	7.01659e-14	0.005443	1	0
POU4F2	5458	broad.mit.edu	37	4	147561705	147561705	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:147561705G>T	uc003ikv.2	+	2	1223	c.975G>T	c.(973-975)GAG>GAT	p.E325D		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	325	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					GGCTCGAGGAGGCCGAGAAGT	0.592			NA											28	84					4.34311e-12	5.90063e-12	0.003271	1	0
NR3C2	4306	broad.mit.edu	37	4	149356498	149356498	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:149356498C>A	uc003ilj.3	-	2	1849	c.1515G>T	c.(1513-1515)GAG>GAT	p.E505D	NR3C2_uc003ilk.3_Missense_Mutation_p.E505D|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	505	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGATGCTGGCCTCTGGGTAAT	0.493	Melanoma(27;428 957 40335 51025 51111)		NA											40	136					2.75727e-19	4.42511e-19	0.004878	1	0
TIGD4	201798	broad.mit.edu	37	4	153692094	153692094	+	Silent	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:153692094T>C	uc003imy.2	-	2	845	c.63A>G	c.(61-63)CTA>CTG	p.L21L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	21	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					CCTCAATGGATAGGCTTTTCT	0.388			NA											36	107					0	0	0.004878	0	0
FGB	2244	broad.mit.edu	37	4	155487128	155487128	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:155487128T>A	uc003ioa.3	+	2	322	c.283T>A	c.(283-285)TGT>AGT	p.C95S	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.C92S|FGB_uc010ipv.2_Intron|FGB_uc010ipw.2_Missense_Mutation_p.C92S|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	95			Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGCTGGAGGCTGTCTTCACGC	0.552	NSCLC(106;1133 1613 21870 46110 52656)		NA											21	49					0	0	0.002299	0	0
GLRB	2743	broad.mit.edu	37	4	158058029	158058029	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:158058029C>A	uc003ipj.2	+	6	803	c.601C>A	c.(601-603)CTG>ATG	p.L201M		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	201	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CAAGATGCAACTGGAGAGCTG	0.363			NA											31	65					3.00307e-07	3.42463e-07	0.008361	1	0
MARCH1	55016	broad.mit.edu	37	4	164466875	164466875	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:164466875G>T	uc003iqs.1	-	7	1421	c.444C>A	c.(442-444)ACC>ACA	p.T148T	MARCH1_uc003iqr.1_Silent_p.T131T	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	148					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TTTCACTTGTGGTCATCTGTA	0.423			NA											33	89					3.99451e-17	6.18403e-17	0.009535	1	0
C4orf39	152756	broad.mit.edu	37	4	165878351	165878351	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:165878351G>T	uc003iqx.1	+	1	252	c.177G>T	c.(175-177)TTG>TTT	p.L59F	TRIM61_uc003iqw.2_Intron	NM_153027	NP_694572	Q96MZ4	CD039_HUMAN	hypothetical protein LOC152756	59											0	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.146)		GTGTCTCTTTGCTCAGACATC	0.612			NA											5	24					5.4927e-09	6.64862e-09	0.004482	1	0
TLL1	7092	broad.mit.edu	37	4	166935713	166935713	+	Splice_Site	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:166935713G>T	uc003irh.1	+	8	1689	c.1042_splice	c.e8+1	p.A348_splice	TLL1_uc011cjn.1_Splice_Site_p.A348_splice|TLL1_uc011cjo.1_Splice_Site_p.A172_splice	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AGATGTCCAGGTATTGCACTA	0.458			NA											44	191					2.00842e-17	3.14639e-17	0.002522	1	0
GPM6A	2823	broad.mit.edu	37	4	176556078	176556078	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:176556078T>A	uc003iuf.2	-	7	1619	c.815A>T	c.(814-816)GAG>GTG	p.E272V	GPM6A_uc011ckj.1_Missense_Mutation_p.E265V|GPM6A_uc003iug.2_Missense_Mutation_p.E272V|GPM6A_uc003iuh.2_Missense_Mutation_p.E261V	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	272	Cytoplasmic (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		ATTGAGCCGCTCTTTGGAGCG	0.448			NA											26	68					0	0	0.00632	0	0
WDR17	116966	broad.mit.edu	37	4	177069477	177069477	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:177069477G>T	uc003iuj.2	+	14	2116	c.1960G>T	c.(1960-1962)GAT>TAT	p.D654Y	WDR17_uc003iuk.2_Missense_Mutation_p.D630Y|WDR17_uc003ium.3_Missense_Mutation_p.D630Y|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_5'Flank	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	654	WD 12.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCACGGTGCAGATGTATATGG	0.363			NA											18	96					6.49762e-13	9.17585e-13	0.006122	1	0
VEGFC	7424	broad.mit.edu	37	4	177608608	177608608	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:177608608C>A	uc003ius.1	-	6	1308	c.878G>T	c.(877-879)TGT>TTT	p.C293F		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	293	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|1.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TCTGCAGACACACTGACAGGT	0.483			NA											23	89					1.55795e-14	2.26924e-14	0.001882	1	0
FAM149A	25854	broad.mit.edu	37	4	187077232	187077232	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:187077232G>T	uc003iyt.3	+	7	1041	c.462G>T	c.(460-462)CCG>CCT	p.P154P	FAM149A_uc011cla.1_Silent_p.P154P|FAM149A_uc010isj.2_Silent_p.P154P|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Silent_p.P154P|FAM149A_uc010isl.2_Silent_p.P154P|FAM149A_uc011clb.1_Silent_p.P154P	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	445										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		CTGTTTCCCCGCGTGACTGTG	0.458			NA											25	83					9.57634e-11	1.23707e-10	0.00333	1	0
ZFP42	132625	broad.mit.edu	37	4	188924008	188924008	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:188924008G>T	uc003izg.1	+	3	292	c.47G>T	c.(46-48)GGC>GTC	p.G16V	ZFP42_uc003izh.1_Missense_Mutation_p.G16V|ZFP42_uc003izi.1_Missense_Mutation_p.G16V	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	16					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		CACCAGAAAGGCCTGGGTGGA	0.547			NA											25	132					1.1804e-14	1.73213e-14	0.003954	1	0
TRIML2	205860	broad.mit.edu	37	4	189020209	189020209	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:189020209C>A	uc003izl.2	-	4	487	c.451G>T	c.(451-453)GGC>TGC	p.G151C	TRIML2_uc003izj.1_Translation_Start_Site|TRIML2_uc003izk.1_Translation_Start_Site|TRIML2_uc011cle.1_Missense_Mutation_p.G201C|TRIML2_uc011clf.1_Missense_Mutation_p.G201C	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	151							ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GCCAAGGTGCCTTCCCCACAC	0.458			NA											27	94					7.92952e-12	1.06994e-11	0.003954	1	0
SLC6A3	6531	broad.mit.edu	37	5	1422011	1422011	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:1422011C>A	uc003jck.2	-	5	893	c.772G>T	c.(772-774)GGC>TGC	p.G258C		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	258					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GTCTTCACGCCCTTCCAGAGG	0.642			NA											55	94					1.19403e-26	2.14328e-26	0.00361	1	0
SEMA5A	9037	broad.mit.edu	37	5	9063152	9063152	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:9063152C>A	uc003jek.2	-	18	3077	c.2365G>T	c.(2365-2367)GCC>TCC	p.A789S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	789	TSP type-1 5.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GACGTCCAGGCTGACCAAGCC	0.582			NA											17	60					3.45872e-05	3.76446e-05	0.004007	1	0
CTNND2	1501	broad.mit.edu	37	5	11022998	11022998	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:11022998G>T	uc003jfa.1	-	17	3027	c.2882C>A	c.(2881-2883)ACA>AAA	p.T961K	CTNND2_uc010itt.2_Missense_Mutation_p.T870K|CTNND2_uc011cmy.1_Missense_Mutation_p.T624K|CTNND2_uc011cmz.1_Missense_Mutation_p.T528K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.T553K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	961					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCAGACAGCTGTCACTGTGTC	0.547			NA											28	96					8.24728e-16	1.24024e-15	0.004656	1	0
FBXL7	23194	broad.mit.edu	37	5	15936573	15936573	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:15936573A>C	uc003jfn.1	+	4	1235	c.754A>C	c.(754-756)ACC>CCC	p.T252P		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	252					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CTCCAAAGTGACCTGCATCAG	0.577			NA											17	31					0	0	0.00499	0	0
CDH9	1007	broad.mit.edu	37	5	26915967	26915967	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:26915967G>A	uc003jgs.1	-	3	463	c.294C>T	c.(292-294)GGC>GGT	p.G98G	CDH9_uc010iug.2_Silent_p.G98G	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	98	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G98C(1)		ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CAAATAGACTGCCAGCCCCAT	0.368	Melanoma(8;187 585 15745 40864 52829)		NA											48	154					0	0	0.00361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33643548	33643548	+	Missense_Mutation	SNP	C	C	A	rs138321976		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:33643548C>A	uc003jia.1	-	10	1670	c.1507G>T	c.(1507-1509)GTG>TTG	p.V503L	ADAMTS12_uc010iuq.1_Missense_Mutation_p.V503L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	503	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAGCCCTTCACGGAGCACCAC	0.468			NA								HNSCC(64;0.19)			42	110					1.41504e-22	2.39795e-22	0.002852	1	0
SLC1A3	6507	broad.mit.edu	37	5	36686351	36686351	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:36686351G>T	uc003jkj.3	+	10	2085	c.1609G>T	c.(1609-1611)GAC>TAC	p.D537Y	SLC1A3_uc011cox.1_Missense_Mutation_p.D430Y|SLC1A3_uc010iuy.2_Missense_Mutation_p.D492Y	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	537					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	GAAACCCATCGACAGTGAAAC	0.363			NA											64	128					2.50483e-33	4.80244e-33	0.00361	1	0
WDR70	55100	broad.mit.edu	37	5	37703180	37703180	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:37703180C>G	uc003jkv.2	+	13	1465	c.1407C>G	c.(1405-1407)ATC>ATG	p.I469M		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	469	WD 7.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATAGACATCACAGATGCGG	0.393			NA											16	126					0	0	0.004007	0	0
HEATR7B2	133558	broad.mit.edu	37	5	40999785	40999785	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:40999785G>C	uc003jmj.3	-	40	5069	c.4579C>G	c.(4579-4581)CTC>GTC	p.L1527V	HEATR7B2_uc003jmi.3_Missense_Mutation_p.L1082V	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1527							binding			ovary(6)|central_nervous_system(2)	8						TCACCTGTGAGTTTGACAGCT	0.483			NA											25	73					0	0	0.003954	0	0
ESM1	11082	broad.mit.edu	37	5	54281167	54281167	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:54281167C>A	uc003jpk.2	-	1	248	c.179G>T	c.(178-180)GGG>GTG	p.G60V	ESM1_uc010ivt.2_Missense_Mutation_p.G60V	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	60	IGFBP N-terminal.				angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TTCTCCCCGCCCTGCAGCGCA	0.602			NA											23	70					1.96895e-08	2.31572e-08	0.00278	1	0
ANKRD55	79722	broad.mit.edu	37	5	55406997	55406997	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:55406997G>T	uc003jqu.2	-	10	1730	c.1578C>A	c.(1576-1578)CAC>CAA	p.H526Q	ANKRD55_uc003jqt.2_Missense_Mutation_p.H238Q	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	525										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				AGACCTCTTGGTGACCAGGCC	0.463			NA											67	222					1.64915e-30	3.12387e-30	0.00361	1	0
CENPK	64105	broad.mit.edu	37	5	64824289	64824289	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:64824289T>C	uc003jts.2	-	9	799	c.587A>G	c.(586-588)AAA>AGA	p.K196R	CENPK_uc003jtt.2_Missense_Mutation_p.K166R|CENPK_uc003jtu.2_Missense_Mutation_p.K196R	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	196					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		CTTTTTCTTTTTAACACTTCT	0.284			NA											12	33					0	0	0.00245	0	0
ANKRD32	84250	broad.mit.edu	37	5	94014519	94014519	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:94014519A>T	uc003kkr.3	+	15	1914	c.1834A>T	c.(1834-1836)AAA>TAA	p.K612*	ANKRD32_uc003kks.2_5'UTR	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	612										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		TTAGGTCTTCAAACATGAACT	0.299			NA											9	23					0	0	0.003163	0	0
CCDC112	153733	broad.mit.edu	37	5	114611088	114611088	+	Missense_Mutation	SNP	C	C	A	rs141845700		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:114611088C>A	uc003kqy.2	-	6	1007	c.494G>T	c.(493-495)GGT>GTT	p.G165V	CCDC112_uc003kqz.2_Missense_Mutation_p.G248V|CCDC112_uc003kra.2_Missense_Mutation_p.G248V	NM_152549	NP_689762	Q8NEF3	CC112_HUMAN	coiled-coil domain containing 112 isoform 2	165											0		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		ATCCCAGGCACCTTGTCGCCC	0.408			NA											55	139					1.86277e-20	3.07084e-20	0.00361	1	0
AQPEP	206338	broad.mit.edu	37	5	115346543	115346543	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:115346543G>T	uc003kro.2	+	14	2363	c.2199G>T	c.(2197-2199)AGG>AGT	p.R733S	AQPEP_uc003krp.2_Intron|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_Intron	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	733	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TGGTAACCAGGGATCTTGTTT	0.308			NA											20	37					1.01871e-10	1.31168e-10	0.008871	1	0
DMXL1	1657	broad.mit.edu	37	5	118468880	118468880	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:118468880G>T	uc003ksd.2	+	11	1550	c.1369G>T	c.(1369-1371)GGC>TGC	p.G457C	DMXL1_uc010jcl.1_Missense_Mutation_p.G457C|DMXL1_uc003ksc.1_Missense_Mutation_p.G457C	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	457										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAAGGAATTAGGCTGTGATAA	0.343			NA											32	94					2.46105e-21	4.12619e-21	0.002096	1	0
MEGF10	84466	broad.mit.edu	37	5	126774191	126774191	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:126774191C>A	uc003kuh.3	+	18	2527	c.2165C>A	c.(2164-2166)GCT>GAT	p.A722D	MEGF10_uc003kui.3_Missense_Mutation_p.A722D	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	722	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 13.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CATAATGGAGCTTTCTGCAGC	0.532			NA											38	103					1.03172e-35	2.0074e-35	0.00361	1	0
MEGF10	84466	broad.mit.edu	37	5	126776495	126776495	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:126776495C>T	uc003kuh.3	+	19	2660	c.2298C>T	c.(2296-2298)GAC>GAT	p.D766D	MEGF10_uc003kui.3_Silent_p.D766D	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	766	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 14.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACGGAGCTGACTGCGACCACA	0.507			NA											45	107					0	0	0.002852	0	0
FBN2	2201	broad.mit.edu	37	5	127727745	127727745	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:127727745C>A	uc003kuu.2	-	11	2008	c.1569G>T	c.(1567-1569)ATG>ATT	p.M523I	FBN2_uc003kuv.2_Missense_Mutation_p.M490I	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	523	EGF-like 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCTTATAACCCATGTTGCATT	0.348			NA											22	50					3.5997e-14	5.2047e-14	0.002299	1	0
FBN2	2201	broad.mit.edu	37	5	127730885	127730885	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:127730885C>A	uc003kuu.2	-	9	1600	c.1161G>T	c.(1159-1161)CAG>CAT	p.Q387H	FBN2_uc003kuv.2_Missense_Mutation_p.Q354H	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	387	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CACAGCAGCACTGCATTTTCG	0.552			NA											18	36					1.00905e-13	1.44569e-13	0.008871	1	0
SLC27A6	28965	broad.mit.edu	37	5	128324424	128324424	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:128324424C>A	uc003kuy.2	+	4	1213	c.817C>A	c.(817-819)CTG>ATG	p.L273M	SLC27A6_uc003kuz.2_Missense_Mutation_p.L273M	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	273					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGCAGCTATCCTGGGAATTTC	0.358			NA											69	170					6.52717e-41	1.29231e-40	0.00361	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128956400	128956400	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:128956400G>T	uc003kvb.1	+	9	1550	c.1550G>T	c.(1549-1551)GGT>GTT	p.G517V	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	517	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAGAATCTTGGTGACGTTTCA	0.418			NA											55	131					1.54886e-18	2.46566e-18	0.00361	1	0
PKD2L2	27039	broad.mit.edu	37	5	137235237	137235237	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:137235237C>T	uc003lby.2	+	5	613	c.557C>T	c.(556-558)CCT>CTT	p.P186L	PKD2L2_uc010jep.1_Missense_Mutation_p.P126L|PKD2L2_uc003lbw.1_Missense_Mutation_p.P186L|PKD2L2_uc003lbx.2_Missense_Mutation_p.P186L|PKD2L2_uc011cyi.1_5'UTR	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	186	Extracellular (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACCAACTCCCCTTGGCACTGG	0.353			NA											36	51					0	0	0.005524	0	0
GABRG2	2566	broad.mit.edu	37	5	161495054	161495054	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:161495054C>A	uc003lyz.3	+	1	407	c.49C>A	c.(49-51)CCT>ACT	p.P17T	GABRG2_uc010jjc.2_Missense_Mutation_p.P17T|GABRG2_uc003lyy.3_Missense_Mutation_p.P17T|GABRG2_uc011dej.1_5'UTR	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	17					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTACTCGACTCCTGTATTTTC	0.463			NA											22	35					1.55469e-16	2.36506e-16	0.00333	1	0
ODZ2	57451	broad.mit.edu	37	5	167645208	167645208	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:167645208C>T	uc010jjd.2	+	23	4285	c.4285C>T	c.(4285-4287)CTT>TTT	p.L1429F	ODZ2_uc003lzr.3_Missense_Mutation_p.L1199F|ODZ2_uc003lzt.3_Missense_Mutation_p.L802F|ODZ2_uc010jje.2_Missense_Mutation_p.L693F	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CAATGTCATCCTTCGAATCAC	0.498			NA											82	133					0	0	0.00361	0	0
SLIT3	6586	broad.mit.edu	37	5	168096927	168096927	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:168096927C>A	uc003mab.2	-	35	4617	c.4197G>T	c.(4195-4197)GGG>GGT	p.G1399G	SLIT3_uc010jjg.2_Silent_p.G1406G	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1399	EGF-like 8.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACACAAGTCCCCTCCATAGC	0.552	Ovarian(29;311 847 10864 17279 24903)		NA											18	40					6.94344e-10	8.58938e-10	0.006122	1	0
ZNF354A	6940	broad.mit.edu	37	5	178139390	178139390	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:178139390T>A	uc003mjj.2	-	5	1687	c.1489A>T	c.(1489-1491)AAC>TAC	p.N497Y		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	497	C2H2-type 10.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		CCACACTCGTTACATTTATAG	0.388			NA											50	101					0	0	0.00361	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178564850	178564850	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:178564850T>G	uc003mjw.2	-	12	1871	c.1871A>C	c.(1870-1872)GAG>GCG	p.E624A		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	624	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GCACTGCTCCTCGCGGAAGTC	0.701			NA											4	1					0	0	0.009096	0	0
SCGN	10590	broad.mit.edu	37	6	25669751	25669751	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:25669751T>A	uc003nfb.2	+	5	552	c.349T>A	c.(349-351)TAT>AAT	p.Y117N	SCGN_uc010jpz.2_Missense_Mutation_p.N26K	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	117	EF-hand 3.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						TTGGCGCAAATATGACGCTGA	0.398			NA											31	92					0	0	0.002445	0	0
KIAA1949	170954	broad.mit.edu	37	6	30652408	30652408	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:30652408C>G	uc003nra.2	-	2	1619	c.1388G>C	c.(1387-1389)GGG>GCG	p.G463A	KIAA1949_uc003nrb.3_Missense_Mutation_p.G463A	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	463						cytoplasm|cytoskeleton	actin binding				0						GCGGGGGGCCCCCACCCCTGG	0.537			NA											3	6					0	0	0.000602	0	0
MDC1	9656	broad.mit.edu	37	6	30680116	30680116	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:30680116T>C	uc003nrg.3	-	5	2043	c.1603A>G	c.(1603-1605)ATT>GTT	p.I535V	MDC1_uc003nrf.3_Missense_Mutation_p.I189V|MDC1_uc011dmp.1_Missense_Mutation_p.I407V|MDC1_uc003nrh.1_Missense_Mutation_p.I407V|MDC1_uc003nri.2_Missense_Mutation_p.I535V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	535	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ATATGTATAATGGCTGACCCT	0.502			NA						Other_conserved_DNA_damage_response_genes					19	122					0	0	0.007835	0	0
SLC26A8	116369	broad.mit.edu	37	6	35980029	35980029	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:35980029G>A	uc003olm.2	-	3	420	c.309C>T	c.(307-309)GGC>GGT	p.G103G	SLC26A8_uc003oln.2_Silent_p.G103G|SLC26A8_uc003oll.2_Silent_p.G103G	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	103	Helical; (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						CTTGCACAAGGCCAACACTTA	0.438			NA											7	263					0	0	0.001984	0	0
DNAH8	1769	broad.mit.edu	37	6	38758175	38758175	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:38758175A>G	uc003ooe.1	+	18	2724	c.2124A>G	c.(2122-2124)TTA>TTG	p.L708L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATCAACTTTTAAAGAAGGTAT	0.313			NA											20	40					0	0	0.007413	0	0
KCNK16	83795	broad.mit.edu	37	6	39290313	39290313	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:39290313G>T	uc003ooq.2	-	1	18	c.4C>A	c.(4-6)CCC>ACC	p.P2T	KCNK16_uc003oor.3_Missense_Mutation_p.P2T|KCNK16_uc010jwy.2_Missense_Mutation_p.P2T|KCNK16_uc011dtz.1_Missense_Mutation_p.P2T	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	2	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CCAGCACTGGGCATGCTGTGG	0.667			NA											4	8					0.00909568	0.00934471	0.009096	1	0
C6orf130	221443	broad.mit.edu	37	6	41036604	41036604	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:41036604C>A	uc003opm.2	-	5	504	c.332G>T	c.(331-333)GGA>GTA	p.G111V	UNC5CL_uc010jxe.1_Intron|C6orf130_uc010jxg.2_Missense_Mutation_p.G111V|C6orf130_uc003opn.2_Intron	NM_145063	NP_659500	Q9Y530	CF130_HUMAN	hypothetical protein LOC221443	111	Macro.										0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTCAGTGACTCCATTCTTCAG	0.408			NA											18	32					5.03518e-11	6.56908e-11	0.007413	1	0
SLC22A7	10864	broad.mit.edu	37	6	43269342	43269342	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:43269342G>T	uc003out.2	+	7	1072	c.973G>T	c.(973-975)GGG>TGG	p.G325W	SLC22A7_uc010jyl.1_Missense_Mutation_p.G326W|SLC22A7_uc003ous.2_Missense_Mutation_p.G323W	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	325						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			AGTGGCCGCCGGGGAACGGGT	0.587			NA											13	48					4.14922e-12	5.66652e-12	0.004007	1	0
TCTE1	202500	broad.mit.edu	37	6	44254167	44254167	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:44254167C>A	uc003oxi.2	-	3	536	c.380G>T	c.(379-381)AGT>ATT	p.S127I	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	127										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTAGTTCTCACTGTCTATCAG	0.607			NA											17	181					3.62473e-10	4.51944e-10	0.001882	1	0
SPATS1	221409	broad.mit.edu	37	6	44337843	44337843	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:44337843A>G	uc003oxk.2	+	6	1098	c.751A>G	c.(751-753)ATT>GTT	p.I251V	SPATS1_uc003oxg.2_RNA|SPATS1_uc010jzb.2_Missense_Mutation_p.I136V	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	251										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCTTCCACAAATTCCCAAGTG	0.343			NA											29	113					0	0	0.007291	0	0
GPR111	222611	broad.mit.edu	37	6	47646847	47646847	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:47646847C>A	uc010jzj.1	+	4	449	c.448C>A	c.(448-450)CTT>ATT	p.L150I	GPR111_uc010jzk.1_Missense_Mutation_p.L82I|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	150	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CTGCCAGACTCTTAATGCCCT	0.458			NA											11	95					0.000978159	0.00103323	0.000978	1	0
OPN5	221391	broad.mit.edu	37	6	47759675	47759675	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:47759675G>T	uc003ozc.2	+	3	393	c.388G>T	c.(388-390)GAT>TAT	p.D130Y	OPN5_uc003ozd.2_5'UTR	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	130	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TGTCAGCCTGGATCGATATTT	0.463	Melanoma(28;740 973 10870 42660 45347)		NA											25	52					2.21704e-12	3.07575e-12	0.00278	1	0
CRISP1	167	broad.mit.edu	37	6	49806202	49806202	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:49806202C>G	uc003ozw.2	-	7	649	c.570G>C	c.(568-570)AAG>AAC	p.K190N	CRISP1_uc003ozx.2_Intron	NM_001131	NP_001122	P54107	CRIS1_HUMAN	acidic epididymal glycoprotein-like 1 isoform 1	190					fusion of sperm to egg plasma membrane	extracellular space					0	Lung NSC(77;0.0358)					GGACGCCTGTCTTATAAGGTT	0.358			NA											9	130					0	0	0.008291	0	0
TINAG	27283	broad.mit.edu	37	6	54214562	54214562	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:54214562C>A	uc003pcj.2	+	7	1094	c.948C>A	c.(946-948)ACC>ACA	p.T316T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	316					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AAAATGCTACCAACAATGGAT	0.443			NA											47	141					1.89013e-27	3.43977e-27	0.00361	1	0
GFRAL	389400	broad.mit.edu	37	6	55216293	55216293	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:55216293C>A	uc003pcm.1	+	5	699	c.613C>A	c.(613-615)CTT>ATT	p.L205I		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	205	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CAAAGAAGCTCTTCACAGCAA	0.428			NA											47	104					7.88023e-25	1.38608e-24	0.00361	1	0
EYS	346007	broad.mit.edu	37	6	66053948	66053948	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:66053948G>T	uc011dxu.1	-	10	2120	c.1582C>A	c.(1582-1584)CAT>AAT	p.H528N	EYS_uc003peq.2_Missense_Mutation_p.H528N|EYS_uc003per.1_Missense_Mutation_p.H528N	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	528					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GTGCCTTCATGTGGGAACCAA	0.353			NA											22	86					1.55795e-14	2.26924e-14	0.001882	1	0
BAI3	577	broad.mit.edu	37	6	69759227	69759227	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:69759227G>T	uc003pev.3	+	15	2770	c.2322G>T	c.(2320-2322)TTG>TTT	p.L774F	BAI3_uc010kak.2_Missense_Mutation_p.L774F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	774	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATCTAATTTTGCCCACTTTGA	0.289			NA											6	52					0.00116845	0.00122601	0.001168	1	0
COL12A1	1303	broad.mit.edu	37	6	75828759	75828759	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:75828759C>A	uc003phs.2	-	46	7520	c.7354G>T	c.(7354-7356)GGG>TGG	p.G2452W	COL12A1_uc003pht.2_Missense_Mutation_p.G1288W	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2452	Nonhelical region (NC3).|VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						ATGTGCTTGCCTGACTGCTGG	0.423			NA											16	92					9.16793e-09	1.0946e-08	0.00499	1	0
COL12A1	1303	broad.mit.edu	37	6	75893229	75893229	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:75893229C>A	uc003phs.2	-	10	1594	c.1428G>T	c.(1426-1428)AGG>AGT	p.R476S	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.R134S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	476	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TAATCTGGACCCTATTTGGTG	0.353			NA											35	101					5.90632e-09	7.12739e-09	0.002445	1	0
COL12A1	1303	broad.mit.edu	37	6	75899098	75899098	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:75899098C>A	uc003phs.2	-	7	825	c.659_splice	c.e7-1	p.G220_splice	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_5'Flank	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						ATGGCATCCCCTAAAGGGAAA	0.328			NA											20	53					8.10497e-08	9.40607e-08	0.010504	1	0
FILIP1	27145	broad.mit.edu	37	6	76023009	76023009	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:76023009C>A	uc003pia.2	-	5	2912	c.2539G>T	c.(2539-2541)GTG>TTG	p.V847L	FILIP1_uc003phy.1_Missense_Mutation_p.V847L|FILIP1_uc003phz.2_Missense_Mutation_p.V748L|FILIP1_uc010kbe.2_Missense_Mutation_p.V850L|FILIP1_uc003pib.1_Missense_Mutation_p.V599L	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	847										skin(3)|ovary(1)	4						GATCTTTCCACGGGTTTCTTC	0.453			NA											81	252					6.44082e-31	1.22298e-30	0.00361	1	0
ASCC3	10973	broad.mit.edu	37	6	101095256	101095256	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:101095256C>A	uc003pqk.2	-	21	3653	c.3324G>T	c.(3322-3324)AGG>AGT	p.R1108S	ASCC3_uc011eai.1_Missense_Mutation_p.R1010S	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1108	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GATTCAGGAGCCTGTAGGTCA	0.428			NA											42	49					1.15505e-17	1.82036e-17	0.009718	1	0
SLC22A16	85413	broad.mit.edu	37	6	110757068	110757068	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:110757068G>T	uc003puf.2	-	6	1475	c.1408C>A	c.(1408-1410)CCA>ACA	p.P470T	SLC22A16_uc003pue.2_Missense_Mutation_p.P451T	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	470					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		ACAATGGTTGGATACAGCTCA	0.373			NA											21	77					4.54149e-19	7.27376e-19	0.002299	1	0
GPRC6A	222545	broad.mit.edu	37	6	117128061	117128061	+	Silent	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:117128061G>C	uc003pxj.1	-	3	829	c.807C>G	c.(805-807)GCC>GCG	p.A269A	GPRC6A_uc003pxk.1_Silent_p.A269A|GPRC6A_uc003pxl.1_Silent_p.A269A	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	269	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CATTAACCTGGGCTTCTAAAA	0.363			NA											34	68					0	0	0.002445	0	0
GJA1	2697	broad.mit.edu	37	6	121768935	121768935	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:121768935T>G	uc003pyr.2	+	2	1192	c.942T>G	c.(940-942)AGT>AGG	p.S314R	GJA1_uc011ebo.1_Missense_Mutation_p.S215R|GJA1_uc011ebp.1_Missense_Mutation_p.S102R	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	314	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CTAATTACAGTGCAGAACAAA	0.458			NA											38	105					0	0	0.007835	0	0
LAMA2	3908	broad.mit.edu	37	6	129470172	129470172	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:129470172C>A	uc003qbn.2	+	7	1063	c.958C>A	c.(958-960)CAG>AAG	p.Q320K	LAMA2_uc003qbo.2_Missense_Mutation_p.Q320K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	320	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TAGCTGTGATCAGTGCTGTCC	0.408			NA											41	128					1.47197e-15	2.20097e-15	0.007835	1	0
MOXD1	26002	broad.mit.edu	37	6	132693794	132693794	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:132693794G>T	uc003qdf.2	-	4	715	c.616C>A	c.(616-618)CAA>AAA	p.Q206K	MOXD1_uc003qde.2_Missense_Mutation_p.Q138K	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	206	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TTAAACATTTGGCACCAATAT	0.348			NA											21	86					1.50039e-11	1.99377e-11	0.001882	1	0
BCLAF1	9774	broad.mit.edu	37	6	136590641	136590641	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:136590641C>A	uc003qgx.1	-	9	2406	c.2153G>T	c.(2152-2154)AGT>ATT	p.S718I	BCLAF1_uc011edb.1_5'Flank|BCLAF1_uc003qgw.1_Missense_Mutation_p.S545I|BCLAF1_uc003qgy.1_Missense_Mutation_p.S716I|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S716I	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	718					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTTGATCCACTGGATTCCCT	0.403	Colon(142;1534 1789 5427 7063 28491)		NA											19	125					8.28177e-16	1.24305e-15	0.007413	1	0
TXLNB	167838	broad.mit.edu	37	6	139583834	139583834	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:139583834G>T	uc011eds.1	-	5	929	c.764C>A	c.(763-765)ACG>AAG	p.T255K		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	255	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CTGGATGTCCGTGAGGGTACT	0.488			NA											45	117					8.99859e-20	1.46204e-19	0.00361	1	0
UTRN	7402	broad.mit.edu	37	6	144854358	144854358	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:144854358G>T	uc003qkt.2	+	42	6287	c.6195G>T	c.(6193-6195)TGG>TGT	p.W2065C		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2065	Spectrin 14.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ACCAACGCTGGGATGCAATTG	0.438			NA											24	100					1.30988e-24	2.29374e-24	0.002096	1	0
GPR31	2853	broad.mit.edu	37	6	167571250	167571250	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:167571250C>G	uc011egq.1	-	1	70	c.70G>C	c.(70-72)GAG>CAG	p.E24Q		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	24	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AGCCCACACTCCAGCCCCAGC	0.657			NA											8	26					0	0	0.006214	0	0
THBS2	7058	broad.mit.edu	37	6	169648571	169648571	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:169648571G>A	uc003qwt.2	-	4	798	c.550C>T	c.(550-552)CAG>TAG	p.Q184*		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	184	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTTTCCGCCTGCAGGTGCTCG	0.617	Esophageal Squamous(91;219 1934 18562 44706)		NA											67	228					0	0	0.00361	0	0
DLL1	28514	broad.mit.edu	37	6	170594720	170594720	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr6:170594720T>A	uc003qxm.2	-	6	1269	c.799A>T	c.(799-801)ACC>TCC	p.T267S		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	267	Extracellular (Potential).|EGF-like 2.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGCTGGCAGGTGCCATGGAGA	0.607			NA											14	52					0	0	0.005443	0	0
CYP2W1	54905	broad.mit.edu	37	7	1026291	1026291	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:1026291T>A	uc003sjq.1	+	5	690	c.677T>A	c.(676-678)CTG>CAG	p.L226Q	CYP2W1_uc003sjr.1_Missense_Mutation_p.L226Q	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	226					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CTCGGGGCCCTGCTCCAGCTG	0.697			NA											13	68					0	0	0.001855	0	0
TMEM195	392636	broad.mit.edu	37	7	15430314	15430314	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:15430314A>T	uc003stb.1	-	8	974	c.804T>A	c.(802-804)TTT>TTA	p.F268L		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	268					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TGATTGGTTCAAATGTATTAA	0.289			NA											21	122					0	0	0.001882	0	0
SNX13	23161	broad.mit.edu	37	7	17836453	17836453	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:17836453G>A	uc003stw.1	-	25	2869	c.2656C>T	c.(2656-2658)CCA>TCA	p.P886S	SNX13_uc003stv.2_Missense_Mutation_p.P875S|SNX13_uc010kuc.2_Missense_Mutation_p.P672S|SNX13_uc010kub.2_Missense_Mutation_p.P281S			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	886					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CACTCACCTGGCATAATTGCA	0.348			NA											4	117					0	0	0.009096	0	0
HOXA5	3202	broad.mit.edu	37	7	27181480	27181480	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:27181480C>A	uc003syn.1	-	2	848	c.787G>T	c.(787-789)GCG>TCG	p.A263S		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	263					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCCTGCCGCGGCCATGCTC	0.468	Colon(119;75 2200 7557 42868)		NA									OREG0017911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	144					1.67942e-08	1.99004e-08	0.006122	1	0
HERPUD2	64224	broad.mit.edu	37	7	35709856	35709856	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:35709856C>T	uc003tet.2	-	3	1113	c.308G>A	c.(307-309)AGT>AAT	p.S103N	HERPUD2_uc003tes.3_Missense_Mutation_p.S103N	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	103	Ser-rich.				response to unfolded protein	integral to membrane				ovary(3)	3						TGCTTCATGACTTTCTCTATT	0.378			NA											6	91					0	0	0.001984	0	0
TARP	445347	broad.mit.edu	37	7	38305252	38305252	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:38305252G>T	uc003tge.1	-	5	832	c.455C>A	c.(454-456)CCC>CAC	p.P152H	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						AGTGGGCTTGGGGGAAACATC	0.378			NA											35	246					1.07637e-12	1.50921e-12	0.004878	1	0
AMPH	273	broad.mit.edu	37	7	38471793	38471793	+	Missense_Mutation	SNP	C	C	A	rs145380938		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:38471793C>A	uc003tgu.2	-	13	1223	c.1154G>T	c.(1153-1155)TGG>TTG	p.W385L	AMPH_uc003tgv.2_Missense_Mutation_p.W385L|AMPH_uc003tgt.2_Missense_Mutation_p.W138L|AMPH_uc003tgw.1_5'Flank|AMPH_uc010kxl.1_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	385					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GCTTACCGTCCATAGGTCCCA	0.323			NA											20	69					4.96729e-08	5.78172e-08	0.008871	1	0
HECW1	23072	broad.mit.edu	37	7	43436451	43436451	+	Silent	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:43436451A>G	uc003tid.1	+	7	1199	c.594A>G	c.(592-594)GGA>GGG	p.G198G	HECW1_uc011kbi.1_Silent_p.G198G|HECW1_uc003tie.1_Silent_p.G230G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	198	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CCGTCCAAGGACAAGGAAGTC	0.423			NA											14	118					0	0	0.001855	0	0
HECW1	23072	broad.mit.edu	37	7	43447307	43447307	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:43447307G>T	uc003tid.1	+	8	1383	c.778G>T	c.(778-780)GTG>TTG	p.V260L	HECW1_uc011kbi.1_Missense_Mutation_p.V260L|HECW1_uc003tie.1_Missense_Mutation_p.V292L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	260	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGGCAACACCGTGAACCCCAT	0.547			NA											14	82					0.00244969	0.00254329	0.00245	1	0
URGCP	55665	broad.mit.edu	37	7	43918478	43918478	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:43918478T>A	uc003tiw.2	-	6	641	c.584A>T	c.(583-585)GAC>GTC	p.D195V	URGCP_uc003tiu.2_Missense_Mutation_p.D152V|URGCP_uc003tiv.2_Missense_Mutation_p.D120V|URGCP_uc003tix.2_Missense_Mutation_p.D186V|URGCP_uc003tiy.2_Missense_Mutation_p.D152V|URGCP_uc003tiz.2_Missense_Mutation_p.D152V|URGCP_uc011kbj.1_Missense_Mutation_p.D152V	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	195					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CAGGAAACTGTCTGAGGAGAG	0.517			NA											24	54					0	0	0.003954	0	0
PKD1L1	168507	broad.mit.edu	37	7	47869180	47869180	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:47869180C>T	uc003tny.1	-	44	6578	c.6578G>A	c.(6577-6579)GGT>GAT	p.G2193D	C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_5'Flank	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2193	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CCAAGCAAAACCCAAGGCCAT	0.498			NA											30	205					0	0	0.008361	0	0
CDC14C	168448	broad.mit.edu	37	7	48965370	48965370	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:48965370G>T	uc010kyv.1	+	1	1214	c.1102G>T	c.(1102-1104)GAT>TAT	p.D368Y		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						CTCTGGTGTTGATGACATTTC	0.468			NA											4	71					2.74318e-10	3.4586e-10	0.006214	1	0
ZPBP	11055	broad.mit.edu	37	7	50121455	50121455	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:50121455C>A	uc003tou.2	-	3	319	c.249G>T	c.(247-249)GTG>GTT	p.V83V	ZPBP_uc011kci.1_Silent_p.V9V|ZPBP_uc010kyw.2_Silent_p.V83V	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	83					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TTACACATAACACGTGTGGAC	0.353			NA											20	52					2.4624e-09	2.9944e-09	0.008871	1	0
POM121L12	285877	broad.mit.edu	37	7	53104085	53104085	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:53104085G>T	uc003tpz.2	+	1	737	c.721G>T	c.(721-723)GGC>TGC	p.G241C		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	241											0						GCCGAGCCTCGGCCCCTGGAG	0.647			NA											17	60					1.85244e-09	2.26314e-09	0.00333	1	0
ZNF735	730291	broad.mit.edu	37	7	63680006	63680006	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:63680006T>A	uc011kdn.1	+	4	577	c.577T>A	c.(577-579)TCA>ACA	p.S193T		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	193	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATATGGCAAATCATTTTGCAT	0.313			NA											3	10					0	0	0.004672	0	0
WBSCR22	114049	broad.mit.edu	37	7	73101344	73101344	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:73101344G>T	uc003tyt.2	+	5	339	c.281G>T	c.(280-282)CGA>CTA	p.R94L	WBSCR22_uc010lbi.1_Intron|WBSCR22_uc003tyu.2_Missense_Mutation_p.R94L|WBSCR22_uc003tyv.2_Missense_Mutation_p.R56L|WBSCR22_uc003tyw.1_Intron	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	94						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GCTGTGGACCGAGAGATAGAG	0.522			NA											27	125					1.17739e-12	1.64501e-12	0.005443	1	0
CLIP2	7461	broad.mit.edu	37	7	73768231	73768231	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:73768231G>T	uc003uam.2	+	4	1027	c.700G>T	c.(700-702)GTG>TTG	p.V234L	CLIP2_uc003uan.2_Missense_Mutation_p.V234L	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	234						microtubule associated complex				skin(3)	3						GAAGACTGGCGTGGTGCGGTA	0.652			NA											42	180					3.77016e-25	6.64627e-25	0.003214	1	0
HGF	3082	broad.mit.edu	37	7	81388081	81388081	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:81388081C>A	uc003uhl.2	-	3	459	c.294G>T	c.(292-294)TGG>TGT	p.W98C	HGF_uc003uhm.2_Missense_Mutation_p.W98C|HGF_uc003uhn.1_Missense_Mutation_p.W98C|HGF_uc003uho.1_Missense_Mutation_p.W98C|HGF_uc003uhp.2_Missense_Mutation_p.W98C	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	98	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TGAAGGGGAACCAGAGGCATT	0.323			NA											22	115					5.26018e-13	7.44169e-13	0.001882	1	0
CACNA2D1	781	broad.mit.edu	37	7	81978919	81978919	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:81978919C>A	uc003uhr.1	-	2	398	c.142G>T	c.(142-144)GCA>TCA	p.A48S		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	48	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GCTGTTTTTGCCAGTGTGACA	0.358			NA											54	197					2.44813e-32	4.68235e-32	0.00361	1	0
PCLO	27445	broad.mit.edu	37	7	82581394	82581394	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:82581394C>A	uc003uhx.2	-	5	9164	c.8875G>T	c.(8875-8877)GCA>TCA	p.A2959S	PCLO_uc003uhv.2_Missense_Mutation_p.A2959S|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2890					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGAGTAGTTGCAGGCTGCTGT	0.463			NA											42	163					3.09479e-21	5.1558e-21	0.006999	1	0
ZNF804B	219578	broad.mit.edu	37	7	88965693	88965693	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:88965693G>T	uc011khi.1	+	4	3935	c.3397G>T	c.(3397-3399)GAA>TAA	p.E1133*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1133						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGACGGATTAGAAATGTGTCA	0.363			NA								HNSCC(36;0.09)			24	88					7.33532e-06	8.08424e-06	0.003954	1	0
SLC25A13	10165	broad.mit.edu	37	7	95818951	95818951	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:95818951C>A	uc003uof.3	-	8	981	c.790G>T	c.(790-792)GTT>TTT	p.V264F	SLC25A13_uc003uog.3_Missense_Mutation_p.V264F|SLC25A13_uc011kik.1_Missense_Mutation_p.V156F	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	264					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	ATGGGTGTAACCTGACCAAAT	0.353			NA											40	180					6.04917e-29	1.11633e-28	0.006999	1	0
EPHB4	2050	broad.mit.edu	37	7	100417356	100417356	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:100417356C>A	uc003uwn.1	-	6	1611	c.1120G>T	c.(1120-1122)GGG>TGG	p.G374W	EPHB4_uc003uwm.1_Missense_Mutation_p.G281W|EPHB4_uc010lhj.1_Missense_Mutation_p.G374W|EPHB4_uc011kkf.1_Missense_Mutation_p.G374W|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Missense_Mutation_p.G374W	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	374	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGGTCTCCCCCGCAGGGCGCA	0.677	GBM(200;2113 3072 25865 52728)		NA											12	28					0.00185496	0.00194118	0.001855	1	0
MUC17	140453	broad.mit.edu	37	7	100675547	100675547	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:100675547G>A	uc003uxp.1	+	3	903	c.850G>A	c.(850-852)GTG>ATG	p.V284M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	284	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCTCTCAGCGTGATGCTGGT	0.507			NA											37	251					0	0	0.003755	0	0
MUC17	140453	broad.mit.edu	37	7	100678561	100678561	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:100678561G>T	uc003uxp.1	+	3	3917	c.3864G>T	c.(3862-3864)ACG>ACT	p.T1288T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1288	Extracellular (Potential).|Ser-rich.|19.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACCACGCTGGTGACCA	0.473			NA											89	409					2.68325e-40	5.286e-40	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100683947	100683947	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:100683947A>G	uc003uxp.1	+	3	9303	c.9250A>G	c.(9250-9252)AGT>GGT	p.S3084G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3084	Extracellular (Potential).|Ser-rich.|50.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTGAAGTCAGTTCATCTCC	0.507			NA											98	422					0	0	0.00361	0	0
SH2B2	10603	broad.mit.edu	37	7	101944560	101944560	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:101944560C>T	uc011kko.1	+	2	900	c.855C>T	c.(853-855)CCC>CCT	p.P285P		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	242	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						TCGTGCCGCCCAAAGTGAGTT	0.687			NA											4	16					0	0	0.009096	0	0
RELN	5649	broad.mit.edu	37	7	103275876	103275876	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:103275876G>T	uc003vca.2	-	19	2621	c.2461C>A	c.(2461-2463)CCC>ACC	p.P821T	RELN_uc010liz.2_Missense_Mutation_p.P821T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	821					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACATACCTGGGCTCATGATAG	0.368	NSCLC(146;835 1944 15585 22231 52158)		NA											29	90					1.55811e-20	2.57399e-20	0.008361	1	0
PIK3CG	5294	broad.mit.edu	37	7	106513259	106513259	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:106513259G>T	uc003vdv.3	+	4	2248	c.2163G>T	c.(2161-2163)CTG>CTT	p.L721L	PIK3CG_uc003vdu.2_Silent_p.L721L|PIK3CG_uc003vdw.2_Silent_p.L721L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	721					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AAGCCTATCTGAGGGGCTGTG	0.453			NA											39	107					2.19358e-23	3.77411e-23	0.005524	1	0
NRCAM	4897	broad.mit.edu	37	7	107834586	107834586	+	Missense_Mutation	SNP	A	A	T	rs146218985	byFrequency	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:107834586A>T	uc003vfb.2	-	17	2131	c.1660T>A	c.(1660-1662)TAT>AAT	p.Y554N	NRCAM_uc003vfc.2_Missense_Mutation_p.Y548N|NRCAM_uc011kmk.1_Missense_Mutation_p.Y549N|NRCAM_uc003vfd.2_Missense_Mutation_p.Y530N|NRCAM_uc003vfe.2_Missense_Mutation_p.Y530N	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	554	Ig-like 6.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						ACAACTGCATATTCGGGCTGT	0.413			NA											28	134					0	0	0.006999	0	0
ING3	54556	broad.mit.edu	37	7	120608099	120608099	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:120608099G>C	uc003vjn.2	+	8	802	c.668G>C	c.(667-669)GGG>GCG	p.G223A	ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Missense_Mutation_p.G223A|ING3_uc011kns.1_Missense_Mutation_p.G208A	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	223					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					ACTGGTGCAGGGGCAATTACC	0.433			NA											24	66					0	0	0.00278	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652315	121652315	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:121652315C>A	uc003vjy.2	+	12	3610	c.3215C>A	c.(3214-3216)CCC>CAC	p.P1072H	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1072	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACAGTCATGCCCAACATGTAT	0.388			NA											29	105					4.43304e-23	7.56111e-23	0.00632	1	0
GRM8	2918	broad.mit.edu	37	7	126173167	126173167	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:126173167T>C	uc003vlr.2	-	8	2580	c.2269A>G	c.(2269-2271)ATC>GTC	p.I757V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.I757V|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	757	Helical; Name=5; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ATCAAGAGGATACTGTATCCA	0.443			NA								HNSCC(24;0.065)			15	59					0	0	0.00245	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864655	131864655	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:131864655G>T	uc003vra.3	-	20	3894	c.3665C>A	c.(3664-3666)TCC>TAC	p.S1222Y		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1222	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CATCCCCGGGGAGTACTCCAT	0.647			NA											8	21					3.09899e-07	3.51873e-07	0.004482	1	0
PLXNA4	91584	broad.mit.edu	37	7	132192299	132192299	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:132192299C>A	uc003vra.3	-	2	1383	c.1154G>T	c.(1153-1155)TGG>TTG	p.W385L	PLXNA4_uc003vrc.2_Missense_Mutation_p.W385L|PLXNA4_uc003vrb.2_Missense_Mutation_p.W385L	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	385	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACCTTGAGCCAGGCCAGGTC	0.602			NA											23	96					1.96895e-08	2.31572e-08	0.00278	1	0
CALD1	800	broad.mit.edu	37	7	134552466	134552466	+	Translation_Start_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:134552466C>A	uc003vrz.2	+	3	441	c.-18C>A	c.(-20--16)CCCTG>CCATG		CALD1_uc003vry.2_Translation_Start_Site|CALD1_uc003vsa.2_Translation_Start_Site|CALD1_uc003vsb.2_Translation_Start_Site|CALD1_uc010lmm.2_Translation_Start_Site|CALD1_uc011kpt.1_Translation_Start_Site	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1						cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						TCTGGTCTCCCTGAACCTGAA	0.458			NA											6	34					3.59834e-05	3.8949e-05	0.001168	1	0
DGKI	9162	broad.mit.edu	37	7	137151659	137151659	+	Splice_Site	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:137151659C>T	uc003vtt.2	-	26	2499	c.2498_splice	c.e26-1	p.D833_splice	DGKI_uc003vtu.2_Missense_Mutation_p.D543N	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						TGAGATCTGTCTATTCGATAA	0.308			NA											9	62					0	0	0.006214	0	0
DGKI	9162	broad.mit.edu	37	7	137172361	137172361	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:137172361G>A	uc003vtt.2	-	23	2378	c.2377C>T	c.(2377-2379)CAG>TAG	p.Q793*	DGKI_uc003vtu.2_Nonsense_Mutation_p.Q493*	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	793					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTCACCTCCTGTAGGCGGTCT	0.388			NA											41	192					0	0	0.00361	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138768597	138768597	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:138768597G>A	uc003vun.2	-	3	1014	c.626C>T	c.(625-627)CCC>CTC	p.P209L	ZC3HAV1_uc003vup.2_Missense_Mutation_p.P209L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	209					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						GACCACGTCGGGGTTCAGCCC	0.547			NA											32	88					0	0	0.008361	0	0
EPHB6	2051	broad.mit.edu	37	7	142566456	142566456	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:142566456G>T	uc011kst.1	+	15	3032	c.2245G>T	c.(2245-2247)GAG>TAG	p.E749*	EPHB6_uc011ksu.1_Nonsense_Mutation_p.E749*|EPHB6_uc003wbs.2_Nonsense_Mutation_p.E457*|EPHB6_uc003wbt.2_Nonsense_Mutation_p.E223*|EPHB6_uc003wbu.2_Nonsense_Mutation_p.E457*|EPHB6_uc003wbv.2_Nonsense_Mutation_p.E133*	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	749	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGTGCTGACGGAGTTCATGGA	0.647			NA											23	76					1.85244e-09	2.26314e-09	0.00333	1	0
TAS2R60	338398	broad.mit.edu	37	7	143141256	143141256	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:143141256C>G	uc011ktg.1	+	1	711	c.711C>G	c.(709-711)CCC>CCG	p.P237P	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	237	Helical; Name=6; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCCGAGAGCCCAGTGTGCAGG	0.483			NA											53	158					0	0	0.00361	0	0
ZNF282	8427	broad.mit.edu	37	7	148921335	148921335	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:148921335C>T	uc003wfm.2	+	8	1717	c.1612C>T	c.(1612-1614)CGC>TGC	p.R538C	ZNF282_uc011kun.1_Intron|ZNF282_uc003wfo.2_Silent_p.T214T	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	538	C2H2-type 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CATCCACCACCGCAGCCACAC	0.682			NA											11	30					0	0	0.000978	0	0
SSPO	23145	broad.mit.edu	37	7	149486458	149486458	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:149486458G>T	uc010lpk.2	+	30	4434	c.4434G>T	c.(4432-4434)CTG>CTT	p.L1478L		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1478	LDL-receptor class A 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGACTGTCTGGATGCCGCCG	0.687			NA											6	30					5.18039e-06	5.7495e-06	0.00308	1	0
GIMAP8	155038	broad.mit.edu	37	7	150174417	150174417	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:150174417G>T	uc003whj.2	+	5	1877	c.1547G>T	c.(1546-1548)CGC>CTC	p.R516L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	516						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GAGGTCAAGCGCTGTTTGTCC	0.522			NA											29	70					2.48779e-11	3.27276e-11	0.005443	1	0
NCAPG2	54892	broad.mit.edu	37	7	158494630	158494630	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:158494630C>A	uc003wnv.1	-	2	107	c.-38_splice	c.e2-1		NCAPG2_uc003wnw.1_Splice_Site|NCAPG2_uc003wnx.1_Splice_Site|NCAPG2_uc011kwe.1_Splice_Site	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5						cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		TTTTGTAACCCTAATGGAAAA	0.358			NA											18	60					1.02788e-11	1.38221e-11	0.00499	1	0
ESYT2	57488	broad.mit.edu	37	7	158531731	158531731	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:158531731C>G	uc003wob.1	-	18	2397	c.2331G>C	c.(2329-2331)GTG>GTC	p.V777V	ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Silent_p.V216V|ESYT2_uc003woa.1_Silent_p.V354V	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	805	C2 3.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						CATGCACGACCACGATAAGCT	0.607			NA											25	112					0	0	0.00333	0	0
DLGAP2	9228	broad.mit.edu	37	8	1513999	1513999	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:1513999G>T	uc003wpl.2	+	3	1238	c.1141G>T	c.(1141-1143)GCA>TCA	p.A381S	DLGAP2_uc003wpm.2_Missense_Mutation_p.A381S	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	460					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACCAAAGTCGGCAATCCTACC	0.557			NA											9	13					1.76689e-08	2.0843e-08	0.006214	1	0
CSMD1	64478	broad.mit.edu	37	8	2808659	2808659	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:2808659G>T	uc011kwk.1	-	66	10571	c.10181C>A	c.(10180-10182)TCG>TAG	p.S3394*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.S2708*|CSMD1_uc010lrg.2_Nonsense_Mutation_p.S1285*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3394	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCACTGGCGAGGCTTCGCT	0.458			NA											7	36					1.08611e-07	1.25308e-07	0.000978	1	0
FGF20	26281	broad.mit.edu	37	8	16850805	16850805	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:16850805T>A	uc003wxc.1	-	3	545	c.412A>T	c.(412-414)ATC>TTC	p.I138F	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Missense_Mutation_p.H103L	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	138					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TCCCTAAAGATGCATTCGGAA	0.328			NA											16	221					0	0	0.003163	0	0
DOK2	9046	broad.mit.edu	37	8	21768283	21768283	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:21768283C>G	uc003wzy.1	-	4	612	c.519G>C	c.(517-519)CGG>CGC	p.R173R	DOK2_uc003wzx.1_Silent_p.R173R|DOK2_uc003wzz.1_Silent_p.R19R|DOK2_uc010lth.1_Silent_p.R19R	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	173	IRS-type PTB.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TCTCCCCAGCCCGGAGGGTAT	0.642			NA											9	22					0	0	0.004482	0	0
ADRA1A	148	broad.mit.edu	37	8	26721658	26721658	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:26721658C>G	uc003xfh.1	-	1	1265	c.829G>C	c.(829-831)GTG>CTG	p.V277L	ADRA1A_uc003xfc.1_Missense_Mutation_p.V277L|ADRA1A_uc010lul.1_Missense_Mutation_p.V277L|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.V277L|ADRA1A_uc010lum.1_Missense_Mutation_p.V277L|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.V277L	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	277	Helical; Name=6; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CAGCCGACCACGATGCCCAGC	0.572			NA											14	31					0	0	0.004007	0	0
CSPP1	79848	broad.mit.edu	37	8	68030483	68030483	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:68030483G>C	uc003xxi.2	+	14	1618	c.1587G>C	c.(1585-1587)AGG>AGC	p.R529S	CSPP1_uc003xxg.1_Missense_Mutation_p.R521S|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R494S|CSPP1_uc003xxk.2_Missense_Mutation_p.R200S	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	529	Pro-rich.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TTTCATACAGGATTGCACCTC	0.353			NA											53	128					0	0	0.00361	0	0
PRDM14	63978	broad.mit.edu	37	8	70981552	70981552	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:70981552G>T	uc003xym.2	-	2	746	c.544C>A	c.(544-546)CCC>ACC	p.P182T		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GAGGGTTTGGGACCATCCTCT	0.577	NSCLC(129;99 1813 5906 40656 46114)		NA											33	68					3.80469e-20	6.20724e-20	0.009535	1	0
TRPA1	8989	broad.mit.edu	37	8	72968044	72968044	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:72968044C>G	uc003xza.2	-	11	1416	c.1241G>C	c.(1240-1242)TGT>TCT	p.C414S		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	414	ANK 10.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TAGAGGAGTACACCCATCGTT	0.363			NA											10	64					0	0	0.00245	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763833	77763833	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:77763833A>T	uc003yav.2	+	10	4928	c.4541A>T	c.(4540-4542)CAC>CTC	p.H1514L	ZFHX4_uc003yau.1_Missense_Mutation_p.H1559L|ZFHX4_uc003yaw.1_Missense_Mutation_p.H1514L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1514	C2H2-type 12.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCTTGGTCCACTATAATTCA	0.408			NA								HNSCC(33;0.089)			15	43					0	0	0.00245	0	0
PAG1	55824	broad.mit.edu	37	8	81905543	81905543	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:81905543C>A	uc003ybz.2	-	4	632	c.-79_splice	c.e4-1			NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid						epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GAGCTGTGTCCTGCAAAGAGA	0.572			NA											10	18					7.48243e-07	8.41106e-07	0.006214	1	0
PSKH2	85481	broad.mit.edu	37	8	87076322	87076322	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:87076322C>A	uc011lfy.1	-	2	724	c.724G>T	c.(724-726)GCA>TCA	p.A242S		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	242	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			ATGTCCACTGCACTGGTATAA	0.463			NA											25	71					1.42536e-11	1.9037e-11	0.004656	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885855	88885855	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:88885855G>T	uc003ydz.2	-	1	442	c.345C>A	c.(343-345)TAC>TAA	p.Y115*		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	115										ovary(1)	1						TTTTGTGCGGGTATACCCGGA	0.552			NA											44	157					1.34996e-11	1.80606e-11	0.009718	1	0
RUNX1T1	862	broad.mit.edu	37	8	93004039	93004039	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:93004039G>T	uc003yfd.2	-	6	903	c.819C>A	c.(817-819)GGC>GGA	p.G273G	RUNX1T1_uc003yfc.1_Silent_p.G246G|RUNX1T1_uc003yfe.1_Silent_p.G236G|RUNX1T1_uc010mao.2_Silent_p.G246G|RUNX1T1_uc011lgi.1_Silent_p.G284G|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.G236G	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	273					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGTACCGCTGGCCTGGGCTAA	0.507			NA											36	97					2.48696e-23	4.26027e-23	0.003271	1	0
RAD54B	25788	broad.mit.edu	37	8	95412526	95412526	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:95412526C>T	uc003ygk.2	-	7	1208	c.1110G>A	c.(1108-1110)TGG>TGA	p.W370*	RAD54B_uc010may.1_Nonsense_Mutation_p.W177*|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ATTCTTTCTTCCAATTATTCA	0.378			NA						Direct_reversal_of_damage|Homologous_recombination					42	71					0	0	0.00874	0	0
PGCP	10404	broad.mit.edu	37	8	97797421	97797421	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:97797421G>T	uc003yhw.2	+	2	462	c.296G>T	c.(295-297)GGG>GTG	p.G99V	PGCP_uc010mbe.2_Missense_Mutation_p.G99V	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	99					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					CAGCAAGATGGGCTGGAGAAA	0.488			NA											33	66					1.08312e-15	1.62262e-15	0.009535	1	0
PGCP	10404	broad.mit.edu	37	8	97892084	97892084	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:97892084A>T	uc003yhw.2	+	4	866	c.700A>T	c.(700-702)ATT>TTT	p.I234F	PGCP_uc010mbe.2_Missense_Mutation_p.I234F	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	234					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					AACAGCCTGTATTACGGTGGA	0.453			NA											122	198					0	0	0.00361	0	0
VPS13B	157680	broad.mit.edu	37	8	100791128	100791128	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:100791128G>T	uc003yiv.2	+	42	7834	c.7723G>T	c.(7723-7725)GGG>TGG	p.G2575W	VPS13B_uc003yiw.2_Missense_Mutation_p.G2550W	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2575					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAGCATCTTCGGGCAGATGGC	0.453	Colon(161;2205 2542 7338 31318)		NA											42	165					3.38236e-24	5.89668e-24	0.006999	1	0
SPAG1	6674	broad.mit.edu	37	8	101253240	101253240	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:101253240A>G	uc003yjh.1	+	19	2857	c.2771A>G	c.(2770-2772)TAT>TGT	p.Y924C	SPAG1_uc003yji.1_Missense_Mutation_p.Y924C	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	924					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		AAAAGGCAGTATGAGCTTTAA	0.368			NA											37	54					0	0	0.004878	0	0
CSMD3	114788	broad.mit.edu	37	8	113504881	113504881	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:113504881G>T	uc003ynu.2	-	31	5274	c.5115C>A	c.(5113-5115)GGC>GGA	p.G1705G	CSMD3_uc003yns.2_Silent_p.G977G|CSMD3_uc003ynt.2_Silent_p.G1665G|CSMD3_uc011lhx.1_Silent_p.G1601G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1705	Extracellular (Potential).|Sushi 9.					integral to membrane|plasma membrane		p.G1705G(1)		ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCATTATATTGCCTGGATCAA	0.308			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			61	104					2.69953e-25	4.7803e-25	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113529424	113529424	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:113529424C>A	uc003ynu.2	-	28	4754	c.4595G>T	c.(4594-4596)GGG>GTG	p.G1532V	CSMD3_uc003yns.2_Missense_Mutation_p.G804V|CSMD3_uc003ynt.2_Missense_Mutation_p.G1492V|CSMD3_uc011lhx.1_Missense_Mutation_p.G1428V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1532	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATGGGGACCCCTGGGTCACG	0.428			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			53	75					2.84144e-21	4.75383e-21	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113988231	113988231	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:113988231C>A	uc003ynu.2	-	7	1336	c.1177G>T	c.(1177-1179)GAA>TAA	p.E393*	CSMD3_uc003ynt.2_Nonsense_Mutation_p.E353*|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	393	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTCGCTGTTCCTCGGAAAGT	0.502			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			46	227					4.25531e-23	7.27373e-23	0.00361	1	0
SLC30A8	169026	broad.mit.edu	37	8	118174010	118174010	+	Silent	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:118174010C>A	uc003yoh.2	+	5	836	c.606C>A	c.(604-606)GGC>GGA	p.G202G	SLC30A8_uc010mcz.2_Silent_p.G153G|SLC30A8_uc011lia.1_Silent_p.G153G|SLC30A8_uc003yog.2_Silent_p.G153G	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	202	HXXXXX[HY]NH-motif.|Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			GATGCCTTGGCCACAATCACA	0.448	Ovarian(162;1202 1922 6011 16223 52092)		NA											16	112					4.7546e-09	5.77292e-09	0.004007	1	0
COL14A1	7373	broad.mit.edu	37	8	121220515	121220515	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:121220515G>A	uc003yox.2	+	11	1501	c.1236G>A	c.(1234-1236)TTG>TTA	p.L412L	COL14A1_uc003yoy.2_Silent_p.L90L|COL14A1_uc010mde.1_Silent_p.L90L	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	412	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGAAAAACTTGATGTCTTTAA	0.388			NA											32	62					0	0	0.009535	0	0
FER1L6	654463	broad.mit.edu	37	8	125109517	125109517	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:125109517C>T	uc003yqw.2	+	36	4907	c.4701C>T	c.(4699-4701)CGC>CGT	p.R1567R	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1567	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACAAGGGCCGCCTGCAGATGT	0.468			NA											92	144					0	0	0.00361	0	0
ADCY8	114	broad.mit.edu	37	8	131964130	131964130	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:131964130G>C	uc003ytd.3	-	3	1481	c.1225C>G	c.(1225-1227)CGC>GGC	p.R409G	ADCY8_uc010mds.2_Missense_Mutation_p.R409G	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	409	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTCTCATAGCGATGGATGTAG	0.517			NA								HNSCC(32;0.087)			32	83					0	0	0.002096	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994002	143994002	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:143994002G>T	uc003yxk.1	-	8	1345	c.1342C>A	c.(1342-1344)CGC>AGC	p.R448S		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	448					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	AGGCACTGGCGCATGCCAAAG	0.682			NA							Familial_Hyperaldosteronism_type_I				27	166					9.78306e-22	1.64723e-21	0.009535	1	0
INSL4	3641	broad.mit.edu	37	9	5231684	5231684	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:5231684C>T	uc003ziy.2	+	1	266	c.161C>T	c.(160-162)CCA>CTA	p.P54L		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	54					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		ACCACCACCCCAGGAGGGTGG	0.527			NA											39	44					0	0	0.007835	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18639359	18639359	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:18639359A>C	uc003zne.3	+	7	911	c.784A>C	c.(784-786)AAA>CAA	p.K262Q	ADAMTSL1_uc003znb.2_Missense_Mutation_p.K262Q|ADAMTSL1_uc003znc.3_Missense_Mutation_p.K262Q	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	262						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		ATTTCCAGACAAAGAGATACT	0.443			NA											4	48					0	0	0.001168	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744666	37744666	+	Silent	SNP	A	A	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:37744666A>C	uc004aag.1	+	16	2681	c.2637A>C	c.(2635-2637)GCA>GCC	p.A879A	FRMPD1_uc004aah.1_Silent_p.A879A	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	879						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CCCTTGGTGCACCCTCCCCAA	0.607			NA											12	69					0	0	0.003163	0	0
FRMPD1	22844	broad.mit.edu	37	9	37746032	37746032	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:37746032A>T	uc004aag.1	+	16	4047	c.4003A>T	c.(4003-4005)AGC>TGC	p.S1335C	FRMPD1_uc004aah.1_Missense_Mutation_p.S1335C	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1335						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GGACCAGTGCAGCTGTCAGTT	0.577			NA											37	233					0	0	0.004289	0	0
TRPM3	80036	broad.mit.edu	37	9	73253977	73253977	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:73253977G>T	uc004aid.2	-	11	1824	c.1580C>A	c.(1579-1581)ACG>AAG	p.T527K	TRPM3_uc004ahu.2_Missense_Mutation_p.T357K|TRPM3_uc004ahv.2_Intron|TRPM3_uc004ahw.2_Missense_Mutation_p.T399K|TRPM3_uc004ahx.2_Missense_Mutation_p.T374K|TRPM3_uc004ahy.2_Missense_Mutation_p.T399K|TRPM3_uc004ahz.2_Missense_Mutation_p.T374K|TRPM3_uc004aia.2_Missense_Mutation_p.T374K|TRPM3_uc004aib.2_Missense_Mutation_p.T374K|TRPM3_uc004aic.2_Missense_Mutation_p.T527K|TRPM3_uc010mor.2_Missense_Mutation_p.T527K	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	552	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TGGCCCTACCGTATTGTACAA	0.418			NA											23	104					1.66031e-10	2.1136e-10	0.003954	1	0
TMEM2	23670	broad.mit.edu	37	9	74327059	74327059	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:74327059C>A	uc011lsa.1	-	16	3249	c.2709G>T	c.(2707-2709)ATG>ATT	p.M903I	TMEM2_uc010mos.2_Missense_Mutation_p.M840I|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	903						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGAATTCTTCATGAGGAAGC	0.428			NA											23	109					5.26018e-13	7.44169e-13	0.001882	1	0
TMC1	117531	broad.mit.edu	37	9	75387409	75387409	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:75387409G>A	uc004aiz.1	+	13	1362	c.822G>A	c.(820-822)CCG>CCA	p.P274P	TMC1_uc010moz.1_Silent_p.P232P|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.P128P|TMC1_uc010mpa.1_Silent_p.P128P	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	274	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TCAGGTTGCCGCTCTCCTATT	0.383	Pancreas(75;173 1345 14232 34245 43413)		NA											52	211					0	0	0.00361	0	0
TRPM6	140803	broad.mit.edu	37	9	77378052	77378052	+	Splice_Site	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:77378052T>C	uc004ajl.1	-	26	3775	c.3537_splice	c.e26-1	p.R1179_splice	TRPM6_uc004ajk.1_Splice_Site_p.R1174_splice|TRPM6_uc010mpb.1_Splice_Site|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Splice_Site_p.R135_splice	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TCTGTAACCCTAGTGGTGAAG	0.458			NA											9	44					0	0	0.004482	0	0
TRPM6	140803	broad.mit.edu	37	9	77423091	77423091	+	Splice_Site	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:77423091C>A	uc004ajl.1	-	14	1736	c.1498_splice	c.e14-1	p.H500_splice	TRPM6_uc004ajk.1_Splice_Site_p.H495_splice|TRPM6_uc010mpb.1_Splice_Site|TRPM6_uc010mpc.1_Splice_Site_p.H500_splice|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GAAGGGTATGCTGCAACAAAA	0.358			NA											21	78					1.50039e-11	1.99377e-11	0.001882	1	0
FRMD3	257019	broad.mit.edu	37	9	85905627	85905627	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:85905627C>G	uc004ams.1	-	13	1288	c.1086G>C	c.(1084-1086)CAG>CAC	p.Q362H	FRMD3_uc004amr.1_Missense_Mutation_p.Q348H	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	362						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						AACTGCGGCTCTGAGTAATGT	0.527			NA											28	92					0	0	0.007291	0	0
C9orf64	84267	broad.mit.edu	37	9	86559805	86559805	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:86559805T>A	uc004anb.2	-	3	945	c.697A>T	c.(697-699)AGT>TGT	p.S233C	C9orf64_uc004anc.2_Missense_Mutation_p.S92C	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	233											0						ATGGTGATACTGGAGATGTCC	0.428			NA											9	86					0	0	0.004482	0	0
TGFBR1	7046	broad.mit.edu	37	9	101904899	101904899	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:101904899C>T	uc004azc.2	+	5	963	c.887C>T	c.(886-888)ACA>ATA	p.T296I	TGFBR1_uc004azd.2_Missense_Mutation_p.T219I|TGFBR1_uc011lvc.1_Missense_Mutation_p.T227I	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	296	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				AACAGATACACAGTTACTGTG	0.418			NA											8	132					0	0	0.004482	0	0
ALG2	85365	broad.mit.edu	37	9	101980430	101980430	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:101980430G>A	uc004azf.2	-	2	1107	c.1037C>T	c.(1036-1038)TCG>TTG	p.S346L	ALG2_uc004azg.2_Missense_Mutation_p.S253L	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	346					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				GGGTCCACCCGAATTAACAGC	0.507			NA											11	104					0	0	0.008291	0	0
OR13F1	138805	broad.mit.edu	37	9	107267441	107267441	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:107267441G>T	uc011lvm.1	+	1	898	c.898G>T	c.(898-900)GCC>TCC	p.A300S		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						GGTGAAAGTGGCCTTGAAAAA	0.358			NA											9	69					1.12685e-05	1.23671e-05	0.004482	1	0
OR13C8	138802	broad.mit.edu	37	9	107332060	107332060	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:107332060G>T	uc011lvo.1	+	1	612	c.612G>T	c.(610-612)CTG>CTT	p.L204L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGTCGAATCTGATTGTTCTGG	0.353			NA											31	131					3.1745e-13	4.51535e-13	0.008361	1	0
SVEP1	79987	broad.mit.edu	37	9	113221313	113221313	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:113221313C>A	uc010mtz.2	-	19	3740	c.3403G>T	c.(3403-3405)GCA>TCA	p.A1135S	SVEP1_uc010mua.1_Missense_Mutation_p.A1135S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1135					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GCCTTCCCTGCATTAGGTTGG	0.463			NA											35	229					2.20262e-25	3.92684e-25	0.002836	1	0
OR2K2	26248	broad.mit.edu	37	9	114090287	114090287	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:114090287G>T	uc011lwp.1	-	1	427	c.427C>A	c.(427-429)CGG>AGG	p.R143R		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	172	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTAGCCATCCGTGCACAGACG	0.547			NA											93	79					6.08224e-66	1.26126e-65	0.00361	1	0
AKNA	80709	broad.mit.edu	37	9	117139580	117139580	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:117139580C>A	uc004biq.3	-	2	642	c.507G>T	c.(505-507)AGG>AGT	p.R169S	AKNA_uc004bio.3_5'Flank|AKNA_uc004bip.3_Missense_Mutation_p.R88S|AKNA_uc004bir.3_Missense_Mutation_p.R169S|AKNA_uc004bis.3_Missense_Mutation_p.R169S|AKNA_uc010mve.2_Missense_Mutation_p.R50S|AKNA_uc004biu.1_Intron|AKNA_uc004biv.1_Missense_Mutation_p.R169S|AKNA_uc004biw.1_Missense_Mutation_p.R169S	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						CCACCCAGCCCCTGGCCTGAC	0.592			NA											37	62					2.79145e-41	5.54071e-41	0.00361	1	0
PAPPA	5069	broad.mit.edu	37	9	118969862	118969862	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:118969862G>A	uc004bjn.2	+	3	1987	c.1606G>A	c.(1606-1608)GAG>AAG	p.E536K	PAPPA_uc011lxp.1_Missense_Mutation_p.E329K|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	536	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ATGGGACAAGGAGGCCCTGAT	0.433			NA											42	56					0	0	0.002522	0	0
PAPPA	5069	broad.mit.edu	37	9	118982315	118982315	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:118982315C>A	uc004bjn.2	+	5	2399	c.2018C>A	c.(2017-2019)GCG>GAG	p.A673E	PAPPA_uc011lxp.1_Missense_Mutation_p.A368E|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	673					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AGGAAACCAGCGCCTGTTGCC	0.572			NA											127	284					2.68169e-52	5.48876e-52	0.00361	1	0
CIZ1	25792	broad.mit.edu	37	9	130941545	130941545	+	Missense_Mutation	SNP	C	C	G	rs111464781		TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:130941545C>G	uc004btt.2	-	8	1104	c.941G>C	c.(940-942)CGG>CCG	p.R314P	CIZ1_uc004btr.2_Missense_Mutation_p.R314P|CIZ1_uc004bts.2_Missense_Mutation_p.R285P|CIZ1_uc011maq.1_Missense_Mutation_p.R309P|CIZ1_uc004btu.2_Missense_Mutation_p.R290P|CIZ1_uc011mar.1_Missense_Mutation_p.R213P|CIZ1_uc011mas.1_Missense_Mutation_p.R344P|CIZ1_uc004btw.2_Missense_Mutation_p.R314P|CIZ1_uc004btv.2_Missense_Mutation_p.R314P|CIZ1_uc004btx.2_Missense_Mutation_p.R290P	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	314	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						CTGCAGGACCCGTGGCTGGAA	0.632			NA											32	86					0	0	0.00623	0	0
SETX	23064	broad.mit.edu	37	9	135206746	135206746	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:135206746C>T	uc004cbk.2	-	8	1111	c.928G>A	c.(928-930)GAT>AAT	p.D310N	SETX_uc004cbj.2_5'Flank|SETX_uc010mzt.2_5'Flank	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	310					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ACAATAGGATCCATAAGTTGA	0.423			NA											15	63					0	0	0.00245	0	0
KIAA0649	9858	broad.mit.edu	37	9	138378101	138378101	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:138378101T>G	uc004cfr.1	+	4	2294	c.1745T>G	c.(1744-1746)CTC>CGC	p.L582R		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	582						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		AAGACCCCTCTCTCTAAAACA	0.612			NA											57	109					0	0	0.00361	0	0
SOHLH1	402381	broad.mit.edu	37	9	138586907	138586907	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:138586907C>T	uc004cgl.2	-	6	925	c.864G>A	c.(862-864)GCG>GCA	p.A288A	SOHLH1_uc010nbe.2_Silent_p.A288A	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	288					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CGGCCTCCTGCGCCAGCATGG	0.697			NA											3	22					0	0	0.004672	0	0
CACNA1B	774	broad.mit.edu	37	9	140972591	140972591	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:140972591G>T	uc004cog.2	+	35	5120	c.4975G>T	c.(4975-4977)GAG>TAG	p.E1659*	CACNA1B_uc004coi.2_Nonsense_Mutation_p.E871*|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Nonsense_Mutation_p.E14*	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1659	IV.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGCCTGGCACGAGATCATGCT	0.607			NA											9	69					5.4927e-09	6.64862e-09	0.004482	1	0
SFRS17A	8227	broad.mit.edu	37	X	1719992	1719992	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:1719992G>T	uc004cqa.2	+	5	1789	c.1593G>T	c.(1591-1593)GTG>GTT	p.V531V	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	531					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTGTCGTGTGGTCCCCGAGG	0.667			NA											6	47					3.59834e-05	3.8949e-05	0.001168	1	0
ARSH	347527	broad.mit.edu	37	X	2936699	2936699	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:2936699G>T	uc011mhj.1	+	5	889	c.889G>T	c.(889-891)GAT>TAT	p.D297Y		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	297						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGAAGAAATGGATTGGATGGT	0.398			NA											7	27					0.00198382	0.00206506	0.001984	1	0
MXRA5	25878	broad.mit.edu	37	X	3228247	3228247	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:3228247T>A	uc004crg.3	-	7	8154	c.7997A>T	c.(7996-7998)CAG>CTG	p.Q2666L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2666	Ig-like C2-type 11.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAAACGTCCCTGCCCAGCCCC	0.592			NA											28	72					0	0	0.00632	0	0
MXRA5	25878	broad.mit.edu	37	X	3235361	3235361	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:3235361C>T	uc004crg.3	-	6	6518	c.6361G>A	c.(6361-6363)GAG>AAG	p.E2121K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2121	Ig-like C2-type 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCACGCACTCATAGCGCCCG	0.672			NA											3	8					0	0	0.004672	0	0
MXRA5	25878	broad.mit.edu	37	X	3248432	3248432	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:3248432G>T	uc004crg.3	-	4	493	c.336C>A	c.(334-336)TAC>TAA	p.Y112*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	112	LRR 3.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCAGCTTGTTGTAGCTGAACT	0.428			NA											7	13					8.12818e-05	8.70246e-05	0.001984	1	0
FRMPD4	9758	broad.mit.edu	37	X	12734443	12734443	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:12734443A>G	uc004cuz.1	+	15	2371	c.1865A>G	c.(1864-1866)TAC>TGC	p.Y622C	FRMPD4_uc011mij.1_Missense_Mutation_p.Y614C	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	622					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GAGGCAGACTACAGAAGTCTA	0.512			NA											29	71					0	0	0.007291	0	0
DDX53	168400	broad.mit.edu	37	X	23018528	23018528	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:23018528C>T	uc004daj.2	+	1	442	c.354C>T	c.(352-354)AGC>AGT	p.S118S		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	118						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						AACAAGAAAGCTACAACTCAG	0.403			NA											23	52					0	0	0.00278	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254905	30254905	+	Silent	SNP	C	C	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:30254905C>T	uc004dca.1	+	5	1601	c.864C>T	c.(862-864)GTC>GTT	p.V288V		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	288	MAGE.										0						AGATGAAGGTCCTGGAGTTTT	0.493			NA											11	44					0	0	0.008291	0	0
RPGR	6103	broad.mit.edu	37	X	38146132	38146132	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:38146132C>G	uc004ded.1	-	15	2288	c.2120G>C	c.(2119-2121)GGG>GCG	p.G707A	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						ctgctcttccccatccctctt	0			NA											4	11					0	0	0.009096	0	0
RBM10	8241	broad.mit.edu	37	X	47032551	47032551	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:47032551G>T	uc004dhf.2	+	5	836	c.457G>T	c.(457-459)GGC>TGC	p.G153C	RBM10_uc004dhe.1_Missense_Mutation_p.G143C|RBM10_uc004dhg.2_Missense_Mutation_p.G76C|RBM10_uc004dhh.2_Missense_Mutation_p.G153C|RBM10_uc010nhq.2_Missense_Mutation_p.G76C|RBM10_uc004dhi.2_Missense_Mutation_p.G218C	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	153	RRM 1.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GCAGTCGCACGGCGTGCAAGC	0.607	Melanoma(171;120 2705 19495 39241)		NA											11	14					1.08611e-07	1.25308e-07	0.000978	1	0
ARAF	369	broad.mit.edu	37	X	47426307	47426307	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:47426307G>T	uc011mlq.1	+	8	857	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	ARAF_uc011mln.1_Intron|ARAF_uc011mlo.1_Missense_Mutation_p.D108Y|ARAF_uc011mlp.1_Missense_Mutation_p.D242Y|ARAF_uc004dic.1_Missense_Mutation_p.D23Y	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	242					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	TTTCAGCACTGATGGTGAGTC	0.587			NA											29	59					1.7881e-09	2.19133e-09	0.008361	1	0
PJA1	64219	broad.mit.edu	37	X	68381607	68381607	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:68381607T>A	uc004dxh.2	-	2	1761	c.1475A>T	c.(1474-1476)GAT>GTT	p.D492V	PJA1_uc011mpi.1_Missense_Mutation_p.D210V|PJA1_uc004dxg.2_Missense_Mutation_p.D304V|PJA1_uc004dxi.2_Missense_Mutation_p.D437V	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	492							zinc ion binding				0						GTTGTTTCCATCCAGCATGAA	0.478			NA											50	78					0	0	0.00361	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961382	73961382	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:73961382T>C	uc004eby.2	-	3	3627	c.3010A>G	c.(3010-3012)AGT>GGT	p.S1004G		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1004					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CAATAATTACTTGAGCTGACA	0.473			NA											17	71					0	0	0.00499	0	0
ATP7A	538	broad.mit.edu	37	X	77245130	77245130	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:77245130G>T	uc004ecx.3	+	4	1172	c.1012G>T	c.(1012-1014)GTA>TTA	p.V338L	ATP7A_uc004ecw.2_Missense_Mutation_p.V338L	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	338	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AATAGAGGCTGTATCACCGGG	0.418			NA											171	113					7.43762e-64	1.53425e-63	0.00361	1	0
PCDH11X	27328	broad.mit.edu	37	X	91131866	91131866	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:91131866G>T	uc004efk.1	+	2	1472	c.627G>T	c.(625-627)AGG>AGT	p.R209S	PCDH11X_uc004efl.1_Missense_Mutation_p.R209S|PCDH11X_uc004efo.1_Missense_Mutation_p.R209S|PCDH11X_uc010nmv.1_Missense_Mutation_p.R209S|PCDH11X_uc004efm.1_Missense_Mutation_p.R209S|PCDH11X_uc004efn.1_Missense_Mutation_p.R209S|PCDH11X_uc004efh.1_Missense_Mutation_p.R209S|PCDH11X_uc004efj.1_Missense_Mutation_p.R209S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	209	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AGTTAGATAGGGAAGAGAAGG	0.403	NSCLC(38;925 1092 2571 38200 45895)		NA											102	54					2.2063e-47	4.49241e-47	0.00361	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873373	91873373	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:91873373C>A	uc004efk.1	+	7	4323	c.3478C>A	c.(3478-3480)CAT>AAT	p.H1160N	PCDH11X_uc004efl.1_Missense_Mutation_p.H1150N|PCDH11X_uc004efo.1_Missense_Mutation_p.H1123N|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.H1152N|PCDH11X_uc004efn.1_Missense_Mutation_p.H1142N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1160	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATCTCTGGATCATTCCAGCTC	0.542	NSCLC(38;925 1092 2571 38200 45895)		NA											70	59					2.23852e-25	3.98185e-25	0.00361	1	0
ZMAT1	84460	broad.mit.edu	37	X	101152935	101152935	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:101152935C>A	uc011mrl.1	-	5	722	c.411G>T	c.(409-411)CAG>CAT	p.Q137H	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						CATAGTGAGACTGAGCAATAA	0.413			NA											93	48					2.46799e-47	5.0123e-47	0.00361	1	0
ZMAT1	84460	broad.mit.edu	37	X	101153123	101153123	+	Translation_Start_Site	SNP	T	T	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:101153123T>A	uc004ein.2	-	3	489	c.-891A>T	c.(-893--889)TAAGA>TATGA		ZMAT1_uc011mrl.1_Missense_Mutation_p.K100M|ZMAT1_uc011mrm.1_Translation_Start_Site	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3							nucleus	zinc ion binding			ovary(1)	1						CTTCATTTTCTTACCAGGCAC	0.318			NA											20	39					0	0	0.010504	0	0
TEX13A	56157	broad.mit.edu	37	X	104465059	104465059	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:104465059G>C	uc004ema.2	-	2	135	c.23C>G	c.(22-24)CCC>CGC	p.P8R	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P8R	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	8						intracellular	zinc ion binding			ovary(2)	2						CCCGCTACTGGGGTCCTCAGG	0.537			NA											18	21					0	0	0.007413	0	0
KIAA1210	57481	broad.mit.edu	37	X	118284406	118284406	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:118284406C>A	uc004era.3	-	1	137	c.137G>T	c.(136-138)TGT>TTT	p.C46F		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	46										ovary(4)|skin(1)	5						ACAACTGCAACAGCCTTGGGA	0.572			NA											24	27					2.27525e-19	3.66646e-19	0.003954	1	0
THOC2	57187	broad.mit.edu	37	X	122755273	122755273	+	Silent	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:122755273G>A	uc004etu.2	-	31	3983	c.3951C>T	c.(3949-3951)ACC>ACT	p.T1317T	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Silent_p.T138T	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1317	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTCTTTCCTTGGTCTCTCTTG	0.408			NA											93	72					0	0	0.00361	0	0
OR13H1	347468	broad.mit.edu	37	X	130678094	130678094	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:130678094G>T	uc011muw.1	+	1	47	c.47G>T	c.(46-48)GGC>GTC	p.G16V	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					CTCCTTATTGGCATTTCTAAC	0.383			NA											27	122					1.77063e-15	2.63754e-15	0.005443	1	0
GPC4	2239	broad.mit.edu	37	X	132439938	132439938	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:132439938C>A	uc004exc.1	-	6	1229	c.1017G>T	c.(1015-1017)CAG>CAT	p.Q339H	GPC4_uc011mvg.1_Missense_Mutation_p.Q269H	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	339					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTCCACATCCCTGGAAAACCT	0.582			NA											154	262					1.27947e-65	2.64626e-65	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135428122	135428122	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:135428122G>T	uc004ezu.1	+	6	2548	c.2257G>T	c.(2257-2259)GAA>TAA	p.E753*	GPR112_uc010nsb.1_Nonsense_Mutation_p.E548*|GPR112_uc010nsc.1_Nonsense_Mutation_p.E520*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	753	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CAATATGCCTGAATTTAAACT	0.373			NA											51	31					2.69774e-35	5.23602e-35	0.00361	1	0
CD40LG	959	broad.mit.edu	37	X	135730460	135730460	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:135730460C>G	uc004faa.2	+	1	125	c.53C>G	c.(52-54)CCC>CGC	p.P18R	CD40LG_uc010nsd.2_Missense_Mutation_p.P18R|CD40LG_uc010nse.1_5'Flank	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	18	Cytoplasmic (Potential).				anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	ACTGGACTGCCCATCAGCATG	0.423			NA							Immune_Deficiency_with_Hyper-IgM				99	52					0	0	0.00361	0	0
FGF13	2258	broad.mit.edu	37	X	137715045	137715045	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:137715045C>G	uc004fam.2	-	5	1366	c.704G>C	c.(703-705)GGA>GCA	p.G235A	FGF13_uc004fan.2_Missense_Mutation_p.G182A|FGF13_uc011mwi.1_Missense_Mutation_p.G216A|FGF13_uc004faq.2_Missense_Mutation_p.G245A|FGF13_uc004far.2_Missense_Mutation_p.G216A|FGF13_uc011mwj.1_Missense_Mutation_p.G245A|FGF13_uc011mwk.1_Missense_Mutation_p.G189A	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	235					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GGATTTGCCTCCGTTCAGCAC	0.527			NA											150	92					0	0	0.00361	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969330	140969330	+	Silent	SNP	G	G	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:140969330G>T	uc011mwp.1	+	4	657	c.657G>T	c.(655-657)ACG>ACT	p.T219T		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	219	MAGE 1.							p.T219M(1)		skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACACATACACGGGCTACTTTC	0.438			NA											44	177					1.23103e-26	2.20466e-26	0.003214	1	0
MAGEC3	139081	broad.mit.edu	37	X	140985421	140985421	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:140985421C>A	uc011mwp.1	+	8	1735	c.1735C>A	c.(1735-1737)CAG>AAG	p.Q579K	MAGEC3_uc004fbs.2_Nonsense_Mutation_p.S328*|MAGEC3_uc010nsj.2_Nonsense_Mutation_p.S328*	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	579	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGCCCATTCAGAGGCCAGC	0.473			NA											104	44					3.06722e-38	6.02735e-38	0.00361	1	0
SPANXN3	139067	broad.mit.edu	37	X	142596702	142596702	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:142596702T>C	uc004fbw.2	-	2	456	c.368A>G	c.(367-369)CAG>CGG	p.Q123R		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	123										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCATCCTCCTGTGAGGATCC	0.453			NA											61	91					0	0	0.00361	0	0
PASD1	139135	broad.mit.edu	37	X	150840994	150840994	+	Missense_Mutation	SNP	G	G	T	rs147522572	byFrequency	TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:150840994G>T	uc004fev.3	+	14	2109	c.1777G>T	c.(1777-1779)GTA>TTA	p.V593L		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	593						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCCACGTGACGTATCTGTGCC	0.393			NA											58	83					1.61742e-36	3.17046e-36	0.00361	1	0
CNGA2	1260	broad.mit.edu	37	X	150912077	150912077	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:150912077G>A	uc004fey.1	+	7	1326	c.1102G>A	c.(1102-1104)GTG>ATG	p.V368M		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	368	Helical; Name=H5; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCACCATCGTGGGAAATGT	0.507			NA											81	76					0	0	0.00361	0	0
HCFC1	3054	broad.mit.edu	37	X	153227748	153227748	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:153227748G>A	uc004fjp.2	-	5	1250	c.722C>T	c.(721-723)ACG>ATG	p.T241M		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	241	Kelch 4.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTATTCCACGTCAGGGTGTC	0.567			NA											14	27					0	0	0.00245	0	0
CLIC2	1193	broad.mit.edu	37	X	154509358	154509358	+	Splice_Site	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:154509358C>G	uc004fnf.2	-	4	544	c.294_splice	c.e4-1	p.R98_splice	CLIC2_uc010nvj.1_Splice_Site_p.R116_splice	NM_001289	NP_001280	O15247	CLIC2_HUMAN	chloride intracellular channel 2						signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity			large_intestine(1)|ovary(1)|skin(1)	3	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTGAGGGTACCTTAAAAAGAA	0.418	Melanoma(108;581 1592 2289 21669 28822)		NA											20	46					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	X	155255036	155255036	+	Silent	SNP	C	C	G			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chrX:155255036C>G	uc004fnx.3	+	9	1246	c.792C>G	c.(790-792)TCC>TCG	p.S264S		NM_182905	NP_878908			WAS protein family homolog 1												NA						ACTGGGAATCCTAGGGGGCTC	0.642			NA											3	17					0	0	0.009096	0	0
SPATA17	128153	broad.mit.edu	37	1	217955584	217955584	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr1:217955584delG	uc001hlh.1	+	8	818	c.792delG	c.(790-792)GTGfs	p.V264fs	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Frame_Shift_Del_p.V264fs	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	264						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		CGTTGCGGGTGGCAGAACCAA	0.448			NA											48	91	---	---	---	---	NA	NA	NA	NA	NA
OR56A4	120793	broad.mit.edu	37	11	6023930	6023930	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:6023930delG	uc010qzv.1	-	1	449	c.449delC	c.(448-450)CCAfs	p.P150fs		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGCAGGCTGGGAAGCTGAT	0.547			NA											36	71	---	---	---	---	NA	NA	NA	NA	NA
DCHS1	8642	broad.mit.edu	37	11	6643491	6643491	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:6643491delC	uc001mem.1	-	21	9826	c.9416delG	c.(9415-9417)GGCfs	p.G3139fs	TPP1_uc001mek.1_5'Flank|TPP1_uc001mel.1_5'Flank|TPP1_uc010rar.1_5'Flank	NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	3139	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATGGCTTGCCATCTGCTGG	0.652			NA											6	13	---	---	---	---	NA	NA	NA	NA	NA
LRRC4C	57689	broad.mit.edu	37	11	40137020	40137020	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:40137020delC	uc001mxa.1	-	2	2787	c.823delG	c.(823-825)GCAfs	p.A275fs	LRRC4C_uc001mxc.1_Frame_Shift_Del_p.A271fs|LRRC4C_uc001mxd.1_Frame_Shift_Del_p.A271fs|LRRC4C_uc001mxb.1_Frame_Shift_Del_p.A271fs	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	275	LRR 9.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTATTGTGTGCCAGGTTGATC	0.428			NA											52	126	---	---	---	---	NA	NA	NA	NA	NA
ALKBH8	91801	broad.mit.edu	37	11	107424656	107424661	+	In_Frame_Del	DEL	ACCATG	ACCATG	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	ACCATG	ACCATG	-	-	ACCATG	ACCATG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr11:107424656_107424661delACCATG	uc010rvr.1	-	4	486_491	c.411_416delCATGGT	c.(409-417)CTCATGGTA>CTA	p.MV138del	ALKBH8_uc001pjk.2_5'Flank|ALKBH8_uc010rvq.1_Translation_Start_Site|ALKBH8_uc009yxp.2_In_Frame_Del_p.MV138del|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	138_139					response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		TTCTTCTACTACCATGAGTCCTGGTG	0.364			NA											9	56	---	---	---	---	NA	NA	NA	NA	NA
WDR25	79446	broad.mit.edu	37	14	100934506	100934507	+	Splice_Site	INS	-	-	T			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr14:100934506_100934507insT	uc010avx.2	+	3	1063	c.970_splice	c.e3+1	p.G324_splice	WDR25_uc001yhm.2_Splice_Site_p.G316_splice|WDR25_uc001yhn.2_Splice_Site_p.G324_splice|WDR25_uc010avy.2_Intron|WDR25_uc001yho.2_Splice_Site_p.G67_splice	NM_001161476	NP_001154948	Q64LD2	WDR25_HUMAN	WD repeat domain 25												0		Melanoma(154;0.212)				CTTGAAACAGGTGCGTTTCTTG	0.629			NA											27	148	---	---	---	---	NA	NA	NA	NA	NA
FAM81A	145773	broad.mit.edu	37	15	59808843	59808843	+	Splice_Site	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr15:59808843delG	uc002agc.2	+	8	974	c.787_splice	c.e8-1	p.G263_splice		NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773											ovary(1)	1						ATGGATCTCAGGGAGCCAGTG	0.408			NA											19	46	---	---	---	---	NA	NA	NA	NA	NA
CASKIN1	57524	broad.mit.edu	37	16	2236767	2236767	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr16:2236767delC	uc010bsg.1	-	10	1021	c.989delG	c.(988-990)GGCfs	p.G330fs		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	330	SH3.				signal transduction	cytoplasm				skin(2)	2						CCGGTCATTGCCCGTCCGGTT	0.672			NA											26	78	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7577594	7577595	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr17:7577594_7577595delAC	uc002gim.2	-	7	880_881	c.686_687delGT	c.(685-687)TGTfs	p.C229fs	TP53_uc002gig.1_Frame_Shift_Del_p.C229fs|TP53_uc002gih.2_Frame_Shift_Del_p.C229fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C97fs|TP53_uc010cng.1_Frame_Shift_Del_p.C97fs|TP53_uc002gii.1_Frame_Shift_Del_p.C97fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C229fs|TP53_uc010cni.1_Frame_Shift_Del_p.C229fs|TP53_uc002gij.2_Frame_Shift_Del_p.C229fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C136fs|TP53_uc002gio.2_Frame_Shift_Del_p.C97fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	229	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> Y (in sporadic cancers; somatic mutation).|C -> G (in a sporadic cancer; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C229fs*10(10)|p.0?(7)|p.C229*(3)|p.C229S(2)|p.C229R(2)|p.C229Y(2)|p.C229_H233delCTTIH(2)|p.T230fs*9(1)|p.C229fs*1(1)|p.C229fs*18(1)|p.C229_T230insX(1)|p.C229C(1)|p.V225fs*23(1)|p.D228fs*12(1)|p.C229G(1)|p.C229_I232del(1)|p.S227_I232delSDCTTI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGATGGTGGTACAGTCAGAGCC	0.525	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	47	---	---	---	---	NA	NA	NA	NA	NA
PTPRA	5786	broad.mit.edu	37	20	2945550	2945550	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr20:2945550delG	uc010zqb.1	+	5	510	c.117delG	c.(115-117)ACGfs	p.T39fs	PTPRA_uc002whj.2_Frame_Shift_Del_p.T39fs|PTPRA_uc010zqc.1_Intron|PTPRA_uc002whk.2_Frame_Shift_Del_p.T39fs|PTPRA_uc010zqd.1_Frame_Shift_Del_p.T50fs|PTPRA_uc002whl.2_Frame_Shift_Del_p.T39fs|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Frame_Shift_Del_p.T39fs			P18433	PTPRA_HUMAN	SubName: Full=cDNA FLJ60525, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48);	39	Extracellular (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						ACTCATCAACGGCAGAACCAG	0.388			NA											36	68	---	---	---	---	NA	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187627867	187627868	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr4:187627867_187627868insA	uc003izf.2	-	2	3302_3303	c.3114_3115insT	c.(3112-3117)GTGGAAfs	p.V1038fs	FAT1_uc010iso.1_Frame_Shift_Ins_p.V1038fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1038_1039	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTCCCCTTTTCCACAAAGCTGG	0.485	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			52	167	---	---	---	---	NA	NA	NA	NA	NA
CDH18	1016	broad.mit.edu	37	5	19747207	19747207	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr5:19747207delG	uc003jgc.2	-	3	744	c.367delC	c.(367-369)CACfs	p.H123fs	CDH18_uc003jgd.2_Frame_Shift_Del_p.H123fs|CDH18_uc011cnm.1_Frame_Shift_Del_p.H123fs	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	123	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGCACATAGTGGGTCTTCTGC	0.443			NA											26	174	---	---	---	---	NA	NA	NA	NA	NA
ZNF746	155061	broad.mit.edu	37	7	149191498	149191499	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr7:149191498_149191499insC	uc003wfw.2	-	2	391_392	c.120_121insG	c.(118-123)GGGATGfs	p.G40fs	ZNF746_uc010lpi.2_Frame_Shift_Ins_p.G40fs	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	40_41	Potential.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TTCTCGGCCATCCCGGTTCGAC	0.594			NA											39	186	---	---	---	---	NA	NA	NA	NA	NA
ZFHX4	79776	broad.mit.edu	37	8	77761315	77761315	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr8:77761315delC	uc003yav.2	+	7	3848	c.3461delC	c.(3460-3462)GCAfs	p.A1154fs	ZFHX4_uc003yau.1_Frame_Shift_Del_p.A1199fs|ZFHX4_uc003yaw.1_Frame_Shift_Del_p.A1154fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1154						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAGGATGTTGCAACAAAAAGG	0.393			NA								HNSCC(33;0.089)			4	4	---	---	---	---	NA	NA	NA	NA	NA
CEL	1056	broad.mit.edu	37	9	135940095	135940095	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1676-01A-01D-0969-08	TCGA-64-1676-10A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12a3245e-f3d7-470a-a755-3160de5cd48a	080c8d6b-3003-415a-a33d-8695a3011adb	g.chr9:135940095delG	uc010naa.1	+	3	311	c.295delG	c.(295-297)GGGfs	p.G99fs		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	96	Heparin-binding.				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CAGCACCTACGGGGATGAAGA	0.602			NA											35	115	---	---	---	---	NA	NA	NA	NA	NA
