Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ENO1	2023	broad.mit.edu	37	1	8934896	8934896	+	Silent	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:8934896G>C	uc001apj.1	-	2	223	c.72C>G	c.(70-72)CTC>CTG	p.L24L	ENO1_uc001apk.1_5'UTR|ENO1_uc001apl.1_Silent_p.L24L|ENO1_uc009vmi.1_Silent_p.L24L|ENO1_uc009vmj.1_Silent_p.L24L|ENO1_uc009vmk.1_Missense_Mutation_p.S18C|ENO1_uc009vml.1_Silent_p.L24L|ENO1_uc009vmm.1_RNA	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	24					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TTGAGGTGAAGAGATCAACCT	0.438	Esophageal Squamous(21;302 608 19946 22210 33560)		NA											11	79					0	0	0.004007	0	0
C1QB	713	broad.mit.edu	37	1	22986043	22986043	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:22986043A>C	uc001bgd.2	+	2	226	c.94A>C	c.(94-96)ACC>CCC	p.T32P		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	32					complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCTCAGCTGCACCGGGCCCCC	0.597			NA											15	130					0	0	0.007413	0	0
IQCC	55721	broad.mit.edu	37	1	32672200	32672200	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:32672200G>A	uc001bum.2	+	3	324	c.277G>A	c.(277-279)GAG>AAG	p.E93K	IQCC_uc009vua.2_Missense_Mutation_p.E173K|IQCC_uc010ogz.1_5'UTR|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	93										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGAAGAGTCTGAGGGAGAGGC	0.532			NA											10	64					0	0	0.006214	0	0
GRIK3	2899	broad.mit.edu	37	1	37346391	37346391	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:37346391G>T	uc001caz.2	-	3	529	c.394C>A	c.(394-396)CAC>AAC	p.H132N	GRIK3_uc001cba.1_Missense_Mutation_p.H132N	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	132	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGCTGGATGTGGGGCACCTCC	0.622			NA											16	137					1.15088e-07	1.23538e-07	0.004007	1	0
CYP4B1	1580	broad.mit.edu	37	1	47278291	47278291	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:47278291T>C	uc001cqm.3	+	4	575	c.491T>C	c.(490-492)ATG>ACG	p.M164T	CYP4B1_uc009vyl.1_Missense_Mutation_p.M1T|CYP4B1_uc001cqn.3_Missense_Mutation_p.M164T|CYP4B1_uc009vym.2_Missense_Mutation_p.M149T|CYP4B1_uc010omk.1_Missense_Mutation_p.M1T|CYP4B1_uc010oml.1_Missense_Mutation_p.M1T	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	164					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					ACACGTATCATGCTGGTGAGC	0.577			NA											52	271					0	0	0.01441	0	0
NFIA	4774	broad.mit.edu	37	1	61818168	61818168	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:61818168G>C	uc001czw.2	+	5	1231	c.747G>C	c.(745-747)TTG>TTC	p.L249F	NFIA_uc001czy.2_Missense_Mutation_p.L241F|NFIA_uc010oos.1_Missense_Mutation_p.L294F|NFIA_uc001czv.2_Missense_Mutation_p.L249F	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	249					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						TCTCAGATTTGGAAAGTTCTT	0.378			NA											12	117					0	0	0.004007	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70819665	70819665	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:70819665G>C	uc001dex.3	-	1	753	c.427C>G	c.(427-429)CAC>GAC	p.H143D	ANKRD13C_uc009wbk.2_Missense_Mutation_p.H143D|ANKRD13C_uc001dey.3_Missense_Mutation_p.H143D|HHLA3_uc010oqp.1_5'Flank|HHLA3_uc001dfa.2_5'Flank|HHLA3_uc001dfb.2_5'Flank|HHLA3_uc001dfc.2_5'Flank	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	143	ANK 2.				protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						TCCTCACCGTGATTATCTTTC	0.602			NA											5	34					0	0	0.001168	0	0
ELTD1	64123	broad.mit.edu	37	1	79412033	79412033	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:79412033C>T	uc001diq.3	-	3	407	c.251G>A	c.(250-252)TGT>TAT	p.C84Y		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	84	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TACACACATACAATAATAACT	0.363			NA											9	59					0	0	0.006214	0	0
EXTL2	2135	broad.mit.edu	37	1	101339615	101339615	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:101339615C>A	uc001dtk.1	-	5	1213	c.876G>T	c.(874-876)CAG>CAT	p.Q292H	EXTL2_uc001dtl.1_Missense_Mutation_p.Q292H|EXTL2_uc010ouk.1_Missense_Mutation_p.Q279H|EXTL2_uc001dtm.1_Missense_Mutation_p.Q291H	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	292	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		AATAAGACCTCTGCAGAGCGT	0.393			NA											17	152					1.15919e-05	1.23138e-05	0.008871	1	0
KIAA1324	57535	broad.mit.edu	37	1	109716178	109716178	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:109716178T>C	uc001dwq.2	+	7	915	c.779T>C	c.(778-780)CTG>CCG	p.L260P	KIAA1324_uc009wex.1_Missense_Mutation_p.L260P|KIAA1324_uc009wey.2_Missense_Mutation_p.L260P|KIAA1324_uc010ovg.1_Missense_Mutation_p.L158P	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	260	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		AAGCCTGTGCTGGTGAGAAAC	0.493			NA											5	152					0	0	0.001984	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244			NA											4	48					0	0	0.009096	0	0
TCHH	7062	broad.mit.edu	37	1	152083948	152083948	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:152083948T>A	uc001ezp.2	-	2	1745	c.1745A>T	c.(1744-1746)GAG>GTG	p.E582V	TCHH_uc009wne.1_Missense_Mutation_p.E582V	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	582	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCTCCTCCTCGCGCTTCAG	0.667			NA											7	43					0	0	0.004482	0	0
HRNR	388697	broad.mit.edu	37	1	152190895	152190895	+	Silent	SNP	T	T	G	rs144504025	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:152190895T>G	uc001ezt.1	-	3	3286	c.3210A>C	c.(3208-3210)TCA>TCC	p.S1070S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1070	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGAATGACCTGAGCTAGATC	0.562			NA											8	310					0	0	0.008291	0	0
FLG2	388698	broad.mit.edu	37	1	152323126	152323126	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:152323126G>C	uc001ezw.3	-	3	7209	c.7136C>G	c.(7135-7137)TCA>TGA	p.S2379*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2379							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTCTGTTGACCATGAAAG	0.438			NA											44	270					0	0	0.01441	0	0
IL6R	3570	broad.mit.edu	37	1	154420621	154420621	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:154420621G>C	uc001fez.1	+	7	1407	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	IL6R_uc001ffa.1_Missense_Mutation_p.E324Q	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	324	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCTCCAGCTGAGAACGAGGT	0.463			NA											20	133					0	0	0.021523	0	0
DCST2	127579	broad.mit.edu	37	1	155001740	155001740	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:155001740C>T	uc001fgm.2	-	8	1391	c.1311G>A	c.(1309-1311)CGG>CGA	p.R437R	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	437	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCAGCTGGTGCCGGGCCAGGT	0.587			NA											8	98					0	0	0.008291	0	0
SCAMP3	10067	broad.mit.edu	37	1	155230148	155230148	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:155230148G>A	uc001fjs.2	-	4	614	c.361C>T	c.(361-363)CAG>TAG	p.Q121*	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'UTR|SCAMP3_uc001fju.2_Nonsense_Mutation_p.Q121*|SCAMP3_uc001fjv.2_Nonsense_Mutation_p.Q121*|SCAMP3_uc001fjt.2_Nonsense_Mutation_p.Q95*	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	121	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCAGCATGCTGCAGCTCTCGC	0.582			NA											21	126					0	0	0.021523	0	0
FCRL3	115352	broad.mit.edu	37	1	157665172	157665172	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:157665172G>T	uc001frb.2	-	8	1650	c.1358C>A	c.(1357-1359)GCA>GAA	p.A453E	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.A453E|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.A179E|FCRL3_uc001frc.1_Missense_Mutation_p.A453E	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	453	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GCCATTGTCTGCATCACAGGA	0.537			NA											54	633					1.93748e-29	2.40812e-29	0.01441	1	0
ATP1A4	480	broad.mit.edu	37	1	160141394	160141394	+	Silent	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:160141394G>C	uc001fve.3	+	12	2180	c.1701G>C	c.(1699-1701)CTG>CTC	p.L567L	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Silent_p.L70L	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	567	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTTGAATCTGCCTAGCAGCT	0.458			NA											5	213					0	0	0.001168	0	0
RALGPS2	55103	broad.mit.edu	37	1	178745932	178745932	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:178745932C>G	uc001glz.2	+	2	371	c.33C>G	c.(31-33)GTC>GTG	p.V11V	RALGPS2_uc001gly.1_Silent_p.V11V|RALGPS2_uc010pnb.1_Silent_p.V11V	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	11					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						CAAGCAGTGTCAATATTGCAG	0.433			NA											28	241					0	0	0.015359	0	0
FAM5C	339479	broad.mit.edu	37	1	190195450	190195450	+	Splice_Site	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:190195450T>A	uc001gse.1	-	6	957	c.725_splice	c.e6-1	p.G242_splice	FAM5C_uc010pot.1_Splice_Site_p.G140_splice	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C							extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTGAAGCCCTTGAAGAACAA	0.299			NA											14	57					0	0	0.004007	0	0
C1orf186	440712	broad.mit.edu	37	1	206241647	206241647	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:206241647C>A	uc001hdt.1	-	4	781	c.142G>T	c.(142-144)GCC>TCC	p.A48S		NM_001007544	NP_001007545	Q6ZWK4	CA186_HUMAN	hypothetical protein LOC440712	48						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.0754)			TGGAGACTGGCCGCTTTCAGT	0.448			NA											6	57					0.00198382	0.00205754	0.001984	1	0
C1orf74	148304	broad.mit.edu	37	1	209956824	209956824	+	Silent	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:209956824T>A	uc001hhp.1	-	2	399	c.156A>T	c.(154-156)CCA>CCT	p.P52P		NM_152485	NP_689698	Q96LT6	CA074_HUMAN	hypothetical protein LOC148304	52										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		AGAGCACAGCTGGCTTCAGTC	0.577			NA											27	203					0	0	0.005443	0	0
ESRRG	2104	broad.mit.edu	37	1	216824354	216824354	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:216824354G>T	uc001hkw.1	-	3	716	c.550C>A	c.(550-552)CGC>AGC	p.R184S	ESRRG_uc001hky.1_Missense_Mutation_p.R161S|ESRRG_uc009xdp.1_Missense_Mutation_p.R161S|ESRRG_uc001hkz.1_Intron|ESRRG_uc010puc.1_Missense_Mutation_p.R161S|ESRRG_uc001hla.1_Missense_Mutation_p.R161S|ESRRG_uc001hlb.1_Missense_Mutation_p.R161S|ESRRG_uc010pud.1_5'UTR|ESRRG_uc001hlc.1_Missense_Mutation_p.R161S|ESRRG_uc001hld.1_Missense_Mutation_p.R161S|ESRRG_uc001hkx.1_Missense_Mutation_p.R189S|ESRRG_uc009xdo.1_Missense_Mutation_p.R161S|ESRRG_uc001hle.1_Missense_Mutation_p.R161S	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	184	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TTCATGAAGCGGCAAGCCTGG	0.448			NA											42	104					2.46787e-29	3.05499e-29	0.01441	1	0
ABCB10	23456	broad.mit.edu	37	1	229683401	229683401	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:229683401G>C	uc001htp.3	-	3	809	c.766C>G	c.(766-768)CTG>GTG	p.L256V		NM_012089	NP_036221	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B, member 10	256	Mitochondrial intermembrane (Potential).|Mitochondrial intermembrane (Potential).|ABC transmembrane type-1.					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(2)	2	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				TCCTGCCTCAGAATGGAGGAG	0.478			NA											16	74					0	0	0.00499	0	0
HEATR1	55127	broad.mit.edu	37	1	236755306	236755306	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:236755306C>A	uc001hyd.1	-	11	1534	c.1409G>T	c.(1408-1410)GGA>GTA	p.G470V		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	470					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATACTTTCCTCCACTTGTAGA	0.368			NA											25	100					3.90053e-15	4.51872e-15	0.012213	1	0
OR2M4	26245	broad.mit.edu	37	1	248402705	248402705	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:248402705G>A	uc010pzh.1	+	1	475	c.475G>A	c.(475-477)GTG>ATG	p.V159M		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGGATCATAGTGCTTGCAGC	0.453			NA											90	264					0	0	0.01441	0	0
OR2T4	127074	broad.mit.edu	37	1	248525348	248525348	+	Missense_Mutation	SNP	G	G	A	rs141849195	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:248525348G>A	uc001ieh.1	+	1	466	c.466G>A	c.(466-468)GTG>ATG	p.V156M		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	156	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGACCGCTACGTGGCCATCTG	0.527			NA											46	498					0	0	0.01441	0	0
ANKRD16	54522	broad.mit.edu	37	10	5922263	5922263	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:5922263G>C	uc010qat.1	-	6	1469	c.926C>G	c.(925-927)TCA>TGA	p.S309*	ANKRD16_uc009xie.2_Intron|ANKRD16_uc009xif.2_Nonsense_Mutation_p.S309*|ANKRD16_uc001iiq.2_Intron	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	309	ANK 9.										0						AACGGTACCTGATCGATTTTT	0.284			NA											3	35					0	0	0.001168	0	0
TAF3	83860	broad.mit.edu	37	10	8007006	8007006	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:8007006G>A	uc010qbd.1	+	3	1533	c.1533G>A	c.(1531-1533)GAG>GAA	p.E511E		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	511	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						TGTATGAGGAGAAAACCAAGC	0.378			NA											20	200					0	0	0.01892	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819359	50819359	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:50819359C>T	uc001jhw.2	+	1	1013	c.573C>T	c.(571-573)TTC>TTT	p.F191F	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	191	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTCAGCCTTCGCCGACACGT	0.657			NA											8	17					0	0	0.006214	0	0
DUPD1	338599	broad.mit.edu	37	10	76818123	76818123	+	Silent	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:76818123G>C	uc001jwq.1	-	1	150	c.150C>G	c.(148-150)CCC>CCG	p.P50P		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	50						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GGGTGTACTGGGGACTGCCCT	0.637			NA											7	71					0	0	0.004482	0	0
ZNF503	84858	broad.mit.edu	37	10	77160865	77160865	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:77160865C>T	uc001jxg.2	-	1	649	c.313G>A	c.(313-315)GAG>AAG	p.E105K	C10orf41_uc010qlf.1_5'Flank|C10orf41_uc010qlg.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					GTCCTTACCTCGATGGGGCTG	0.627			NA											3	16					0	0	0.004672	0	0
PPIF	10105	broad.mit.edu	37	10	81112122	81112122	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:81112122C>T	uc001kai.2	+	5	547	c.462C>T	c.(460-462)TTC>TTT	p.F154F	PPIF_uc001kaj.2_Intron	NM_005729	NP_005720	P30405	PPIF_HUMAN	peptidylprolyl isomerase F precursor	154	PPIase cyclophilin-type.				protein folding	membrane fraction|mitochondrial matrix	peptidyl-prolyl cis-trans isomerase activity			skin(1)	1	all_cancers(46;0.0893)|Breast(12;8.52e-05)|all_epithelial(25;0.00449)|Prostate(51;0.00985)		Epithelial(14;0.00242)|all cancers(16;0.0069)|Colorectal(32;0.229)		Dimethyl sulfoxide(DB01093)|L-Proline(DB00172)	GCTCCCAGTTCTTCATCTGCA	0.592			NA											7	99					0	0	0.006214	0	0
IFIT1B	439996	broad.mit.edu	37	10	91144396	91144396	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:91144396C>T	uc001kgh.2	+	2	1406	c.1326C>T	c.(1324-1326)CTC>CTT	p.L442L	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	442	TPR 8.						binding				0						GTGTCAGCCTCCTTGGGCTTA	0.428			NA											102	408					0	0	0.01441	0	0
MMS19	64210	broad.mit.edu	37	10	99238086	99238086	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:99238086G>C	uc001kns.3	-	4	548	c.323C>G	c.(322-324)TCT>TGT	p.S108C	MMS19_uc009xvt.2_Translation_Start_Site|MMS19_uc001knr.2_Translation_Start_Site|MMS19_uc010qox.1_Missense_Mutation_p.S129C|MMS19_uc001knt.2_Missense_Mutation_p.S108C|MMS19_uc001knu.1_5'Flank	NM_022362	NP_071757	Q96T76	MMS19_HUMAN	MMS19 nucleotide excision repair homolog	108					chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)		CTGCAGGACAGATGGGATCAC	0.463			NA						Direct_reversal_of_damage|NER					9	41					0	0	0.006214	0	0
CHUK	1147	broad.mit.edu	37	10	101978567	101978567	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:101978567C>T	uc001kqp.2	-	8	760	c.705G>A	c.(703-705)AAG>AAA	p.K235K		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	235	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		GATCCTTCTTCTTAATCTTCT	0.323	Ovarian(159;52 1904 10536 35305 37148)		NA											6	165					0	0	0.001168	0	0
NRAP	4892	broad.mit.edu	37	10	115364439	115364439	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:115364439G>C	uc001laj.2	-	35	4320	c.4156C>G	c.(4156-4158)CAC>GAC	p.H1386D	NRAP_uc009xyb.2_Missense_Mutation_p.H175D|NRAP_uc001lak.2_Missense_Mutation_p.H1351D|NRAP_uc001lal.3_Missense_Mutation_p.H1386D	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1386	Nebulin 36.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTGAACTTGTGATACTGTGTC	0.587			NA											10	113					0	0	0.013537	0	0
INPP5F	22876	broad.mit.edu	37	10	121510631	121510631	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:121510631G>C	uc001leo.2	+	2	307	c.141G>C	c.(139-141)TTG>TTC	p.L47F	INPP5F_uc001len.3_Missense_Mutation_p.L47F	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	47							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GTTTGGGGTTGGTAGAAGGTG	0.328			NA									OREG0020583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	100					0	0	0.001984	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122334782	122334782	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:122334782C>T	uc001lev.1	+	6	937	c.585C>T	c.(583-585)TCC>TCT	p.S195S	PPAPDC1A_uc010qtd.1_Silent_p.S195S|PPAPDC1A_uc009xzl.1_Silent_p.S132S|PPAPDC1A_uc001lew.1_3'UTR|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Silent_p.S74S	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	195	Phosphatase sequence motif III.|Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TTGCCCTGTCCCGCATGTGCG	0.617			NA											24	261					0	0	0.00632	0	0
OR51A2	401667	broad.mit.edu	37	11	4976704	4976705	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:4976704_4976705CA>AT	uc010qyt.1	-	1	239_240	c.239_240TG>AT	c.(238-240)CTG>CAT	p.L80H		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACACAGTGGGCAGAGATGATAA	0.436			NA											120	140					0	0	0.004672	0	0
OVCH2	341277	broad.mit.edu	37	11	7718296	7718296	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:7718296G>T	uc010rbf.1	-	9	976	c.976C>A	c.(976-978)CAC>AAC	p.H326N		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TCTGGGAAGTGCAGCTTCCCC	0.552			NA											13	35					6.94344e-10	7.69544e-10	0.006122	1	0
AMPD3	272	broad.mit.edu	37	11	10527398	10527398	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:10527398G>C	uc001mio.1	+	15	2606	c.2271G>C	c.(2269-2271)ATG>ATC	p.M757I	AMPD3_uc010rbz.1_Missense_Mutation_p.M598I|AMPD3_uc001min.1_Missense_Mutation_p.M766I|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.M764I|AMPD3_uc009yfy.2_Missense_Mutation_p.M757I	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	757					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CTGATGCTATGAAATCAGAAG	0.428			NA											5	241					0	0	0.001168	0	0
CTR9	9646	broad.mit.edu	37	11	10800443	10800443	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:10800443G>A	uc001mja.2	+	25	3462	c.3313G>A	c.(3313-3315)GAA>AAA	p.E1105K		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	1105	Ser-rich.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTCTGACAATGAATCTGTGCA	0.557			NA											38	85					0	0	0.006999	0	0
SLC17A6	57084	broad.mit.edu	37	11	22387212	22387212	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:22387212G>A	uc001mqk.2	+	7	1281	c.868G>A	c.(868-870)GCA>ACA	p.A290T		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	290	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGGAGAGAGTGCAAATCTTTT	0.378			NA											30	192					0	0	0.021022	0	0
IMMP1L	196294	broad.mit.edu	37	11	31477921	31477921	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:31477921C>A	uc001msy.1	-	5	403	c.207G>T	c.(205-207)GTG>GTT	p.V69V	IMMP1L_uc001msz.1_Silent_p.V69V|IMMP1L_uc009yjo.2_Silent_p.V69V|IMMP1L_uc009yjp.2_RNA	NM_144981	NP_659418	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane	69					proteolysis	mitochondrial inner membrane	serine-type peptidase activity				0	Lung SC(675;0.225)					TTTTTGCAATCACAATGTCAC	0.343			NA											21	82					6.32553e-13	7.24604e-13	0.004656	1	0
C11orf41	25758	broad.mit.edu	37	11	33565250	33565250	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:33565250C>G	uc001mup.3	+	1	1374	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C	C11orf41_uc001mun.1_Missense_Mutation_p.S417C	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	417						integral to membrane				ovary(2)	2						TCAATAATATCTGGCTTGCAG	0.398			NA									OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	69					0	0	0.019004	0	0
RAG1	5896	broad.mit.edu	37	11	36596881	36596881	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:36596881G>C	uc001mwu.3	+	2	2151	c.2027G>C	c.(2026-2028)AGT>ACT	p.S676T	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	676					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GCCATCCTGAGTCCTCTCATT	0.512	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				55	105					0	0	0.01441	0	0
OR4A5	81318	broad.mit.edu	37	11	51411989	51411989	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:51411989C>A	uc001nhi.1	-	1	407	c.407G>T	c.(406-408)CGA>CTA	p.R136L		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GCAAACCTGTCGATTCATGAT	0.478			NA											39	300					1.06522e-23	1.29771e-23	0.013114	1	0
OR5D18	219438	broad.mit.edu	37	11	55587679	55587679	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:55587679G>T	uc010rin.1	+	1	574	c.574G>T	c.(574-576)GAT>TAT	p.D192Y		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TTCTTGCTCTGATACTTACAT	0.403			NA											59	616					1.55545e-33	1.94907e-33	0.01441	1	0
RAB3IL1	5866	broad.mit.edu	37	11	61674928	61674928	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:61674928C>A	uc001nso.2	-	4	533	c.375G>T	c.(373-375)ATG>ATT	p.M125I	RAB3IL1_uc001nsp.2_Missense_Mutation_p.M172I	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	125	Potential.						protein binding			skin(2)|central_nervous_system(1)	3						CTTCTCGAACCATCTTGTGAG	0.627			NA											6	33					0.000274275	0.00028738	0.004482	1	0
SPTBN2	6712	broad.mit.edu	37	11	66472402	66472402	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:66472402G>A	uc001ojd.2	-	14	2417	c.2345C>T	c.(2344-2346)ACG>ATG	p.T782M		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	782	Spectrin 5.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TAGAGCCTGCGTGGAGAACTC	0.662			NA											14	40					0	0	0.006122	0	0
CPT1A	1374	broad.mit.edu	37	11	68549256	68549256	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:68549256G>A	uc001oog.3	-	11	1505	c.1335C>T	c.(1333-1335)CAC>CAT	p.H445H	CPT1A_uc001oof.3_Silent_p.H445H|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	445	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	AACATCGGCCGTGTAGTAGAG	0.488			NA											15	776					0	0	0.003163	0	0
FOLR4	390243	broad.mit.edu	37	11	94040706	94040706	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:94040706C>T	uc010rud.1	+	4	580	c.580C>T	c.(580-582)CGG>TGG	p.R194W		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	201						extracellular region	folic acid binding|receptor activity			ovary(1)	1						CCCTGAGCGACGGAACAGTGG	0.612			NA											74	654					0	0	0.01441	0	0
AASDHPPT	60496	broad.mit.edu	37	11	105948530	105948530	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:105948530C>G	uc001pjc.1	+	1	239	c.93C>G	c.(91-93)GCC>GCG	p.A31A	KBTBD3_uc001pja.2_5'Flank|KBTBD3_uc001pjb.2_5'Flank|KBTBD3_uc009yxm.2_5'Flank|AASDHPPT_uc010rvn.1_RNA	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	31					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		CGAGCCGAGCCGAATGGCTGC	0.607			NA											10	63					0	0	0.008871	0	0
SIK2	23235	broad.mit.edu	37	11	111583037	111583037	+	Missense_Mutation	SNP	C	C	G	rs139007229	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:111583037C>G	uc001plt.2	+	9	1322	c.1204C>G	c.(1204-1206)CCA>GCA	p.P402A		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	402					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						CTTTTCATTTCCAGCATCTGG	0.547			NA											5	102					0	0	0.014758	0	0
ARCN1	372	broad.mit.edu	37	11	118468445	118468445	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:118468445T>C	uc001ptq.2	+	9	1426	c.1265T>C	c.(1264-1266)ATC>ACC	p.I422T	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Missense_Mutation_p.I334T|ARCN1_uc009zag.2_Missense_Mutation_p.I463T	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	422	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GCGCCTGTTATCGGTGAGATC	0.512			NA											10	55					0	0	0.008291	0	0
NCAPD3	23310	broad.mit.edu	37	11	134048744	134048744	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr11:134048744G>T	uc001qhd.1	-	21	3253	c.2647C>A	c.(2647-2649)CTG>ATG	p.L883M	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	883					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GACGAAGCCAGGACGGACTGA	0.478			NA											4	105					3.59834e-05	3.78318e-05	0.001168	1	0
PHB2	11331	broad.mit.edu	37	12	7077178	7077178	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:7077178G>A	uc001qsd.2	-	5	694	c.484C>T	c.(484-486)CTG>TTG	p.L162L	PHB2_uc010sft.1_Silent_p.L162L|PHB2_uc010sfu.1_Silent_p.L162L|PHB2_uc001qse.1_5'Flank|PHB2_uc001qsf.1_5'Flank|PHB2_uc009zfn.1_5'Flank|SCARNA12_uc001qsg.2_5'Flank	NM_001144831	NP_001138303	Q99623	PHB2_HUMAN	prohibitin 2 isoform 1	162	Necessary for transcriptional repression.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CGGATCAACAGGGATACCTga	0.378			NA											10	23					0	0	0.008291	0	0
KLRC2	3822	broad.mit.edu	37	12	10583765	10583765	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:10583765G>C	uc001qyk.2	-	6	654	c.647C>G	c.(646-648)TCA>TGA	p.S216*	KLRC3_uc001qyh.2_Intron|KLRC2_uc010she.1_Nonsense_Mutation_p.S216*	NM_002260	NP_002251	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C,	216	Extracellular (Potential).|C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						ACACTGGGCTGATTTAAGTCG	0.323			NA											4	112					0	0	0.00308	0	0
KLRC1	3821	broad.mit.edu	37	12	10599199	10599199	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:10599199G>C	uc001qyl.2	-	7	817	c.653C>G	c.(652-654)TCA>TGA	p.S218*	KLRC1_uc009zhm.1_Nonsense_Mutation_p.S218*|KLRC1_uc001qym.2_Nonsense_Mutation_p.S200*|KLRC1_uc001qyn.2_Nonsense_Mutation_p.S218*|KLRC1_uc001qyo.2_Nonsense_Mutation_p.S200*	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	218	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						ACACTGGGCTGATTTAAGTCG	0.323			NA											62	238					0	0	0.01441	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21242939	21242939	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:21242939G>T	uc010sil.1	+	16	2211	c.2146G>T	c.(2146-2148)GAT>TAT	p.D716Y	LST-3TM12_uc010sim.1_Missense_Mutation_p.D655Y|LST-3TM12_uc010sin.1_Missense_Mutation_p.D608Y			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	655	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCATGGAAAGGATACCAAAGT	0.343			NA											26	75					2.48779e-11	2.80792e-11	0.005443	1	0
ST8SIA1	6489	broad.mit.edu	37	12	22354963	22354963	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:22354963G>A	uc001rfo.3	-	5	1076	c.594C>T	c.(592-594)AAC>AAT	p.N198N	ST8SIA1_uc009zix.2_Silent_p.N55N	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	198	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						ACCACAGAAGGTTCTGAAACC	0.388			NA											16	74					0	0	0.006122	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945637	43945637	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:43945637G>T	uc010skx.1	-	1	88	c.88C>A	c.(88-90)CAA>AAA	p.Q30K		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	30						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTTTACCTTGCCTGGGGTGG	0.647			NA											24	97					4.72057e-08	5.08497e-08	0.021523	1	0
CALCOCO1	57658	broad.mit.edu	37	12	54119004	54119004	+	Missense_Mutation	SNP	C	C	A	rs149998353	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:54119004C>A	uc001sef.2	-	2	167	c.23G>T	c.(22-24)CGG>CTG	p.R8L	CALCOCO1_uc010som.1_Missense_Mutation_p.R8L|CALCOCO1_uc010son.1_5'UTR|CALCOCO1_uc001seh.2_Missense_Mutation_p.R8L|CALCOCO1_uc009znd.2_Missense_Mutation_p.R8L|CALCOCO1_uc001seg.2_5'UTR|CALCOCO1_uc010soo.1_Missense_Mutation_p.R8L	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	8	p300 KIX-binding (By similarity).|N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GGATGGTGCCCGGCTTAGTGG	0.532			NA											20	45					4.35082e-09	4.75338e-09	0.010504	1	0
SUOX	6821	broad.mit.edu	37	12	56397873	56397873	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:56397873G>A	uc001six.2	+	6	1026	c.700G>A	c.(700-702)GTA>ATA	p.V234I	SUOX_uc001siy.2_Missense_Mutation_p.V234I|SUOX_uc001siz.2_Missense_Mutation_p.V234I|SUOX_uc001sja.2_Missense_Mutation_p.V234I	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	234	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			TCGCTTACACGTAGTAGGAGC	0.522			NA											15	60					0	0	0.006122	0	0
KCNC2	3747	broad.mit.edu	37	12	75442065	75442065	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:75442065G>T	uc001sxg.1	-	4	2192	c.1648C>A	c.(1648-1650)CCG>ACG	p.P550T	KCNC2_uc009zry.2_Missense_Mutation_p.P550T|KCNC2_uc001sxe.2_Missense_Mutation_p.P550T|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Intron	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	550	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.P550L(1)		breast(2)|pancreas(2)|skin(1)|lung(1)	6						GATAGTGGCGGCTCACTTCCT	0.478			NA											31	160					1.08312e-15	1.26433e-15	0.009535	1	0
NAV3	89795	broad.mit.edu	37	12	78452814	78452814	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:78452814G>T	uc001syp.2	+	12	2728	c.2555G>T	c.(2554-2556)AGT>ATT	p.S852I	NAV3_uc001syo.2_Missense_Mutation_p.S852I|NAV3_uc010sub.1_Missense_Mutation_p.S352I	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	852						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TATACTAGAAGTCTGAACCGA	0.398			NA								HNSCC(70;0.22)			25	201					4.59853e-10	5.15237e-10	0.005443	1	0
MGAT4C	25834	broad.mit.edu	37	12	86373302	86373302	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:86373302C>G	uc001tai.3	-	8	2452	c.1202G>C	c.(1201-1203)CGG>CCG	p.R401P	MGAT4C_uc001tal.3_Missense_Mutation_p.R401P|MGAT4C_uc001taj.3_Missense_Mutation_p.R401P|MGAT4C_uc001tak.3_Missense_Mutation_p.R401P|MGAT4C_uc010sum.1_Missense_Mutation_p.R425P|MGAT4C_uc001tah.3_Missense_Mutation_p.R401P	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	401	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						ATCATTTTGCCGATCTTCTGT	0.343			NA											18	64					0	0	0.014323	0	0
POLR3B	55703	broad.mit.edu	37	12	106890582	106890582	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:106890582G>T	uc001tlp.2	+	25	3092	c.2870G>T	c.(2869-2871)AGA>ATA	p.R957I	POLR3B_uc001tlq.2_Missense_Mutation_p.R899I	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	957					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CTGGACGGCAGATTCCACTAC	0.527			NA											47	284					6.31075e-24	7.71873e-24	0.01441	1	0
CORO1C	23603	broad.mit.edu	37	12	109051145	109051145	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:109051145C>T	uc001tnj.2	-	6	781	c.685G>A	c.(685-687)GAT>AAT	p.D229N	CORO1C_uc009zva.2_Missense_Mutation_p.D282N|CORO1C_uc010sxf.1_Missense_Mutation_p.D192N	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	229					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						ACATTGCCATCGGCCAGGAAG	0.547			NA											5	31					0	0	0.014758	0	0
ATXN2	6311	broad.mit.edu	37	12	111893881	111893881	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:111893881G>T	uc001tsj.2	-	23	3858	c.3696C>A	c.(3694-3696)CAC>CAA	p.H1232Q	ATXN2_uc001tsh.2_Missense_Mutation_p.H967Q|ATXN2_uc001tsi.2_Missense_Mutation_p.H925Q|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.H420Q|ATXN2_uc001tsl.1_Missense_Mutation_p.H233Q	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1232					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CCGGCTGAACGTGAGAAGGAT	0.532			NA											87	315					1.03567e-68	1.32479e-68	0.01441	1	0
C12orf51	283450	broad.mit.edu	37	12	112600871	112600871	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:112600871C>T	uc009zwc.2	-	68	11847	c.11829G>A	c.(11827-11829)AAG>AAA	p.K3943K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGGGGGCGATCTTCATGGGGT	0.617			NA											23	141					0	0	0.00632	0	0
C12orf51	283450	broad.mit.edu	37	12	112600874	112600874	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:112600874C>T	uc009zwc.2	-	68	11844	c.11826G>A	c.(11824-11826)ATG>ATA	p.M3942I		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGGCGATCTTCATGGGGTACG	0.612			NA											22	143					0	0	0.007291	0	0
PXN	5829	broad.mit.edu	37	12	120650309	120650309	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:120650309G>A	uc001txt.2	-	12	1715	c.1584C>T	c.(1582-1584)CAC>CAT	p.H528H	uc001txs.1_RNA|PXN_uc001txu.2_Silent_p.H340H|PXN_uc001txv.2_Silent_p.H409H|PXN_uc001txx.2_Silent_p.H361H|PXN_uc001txy.2_Silent_p.H494H|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	528	LIM zinc-binding 3.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGCGCCGCTCGTGGTAGTGCA	0.642			NA											5	28					0	0	0.001168	0	0
POLE	5426	broad.mit.edu	37	12	133257827	133257827	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:133257827C>A	uc001uks.1	-	2	145	c.101G>T	c.(100-102)CGC>CTC	p.R34L	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R34L	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	34					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCGTTCCAGGCGCTTGAGTGC	0.507			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					24	94					2.70662e-09	2.96762e-09	0.009535	1	0
ANKLE2	23141	broad.mit.edu	37	12	133318046	133318046	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:133318046T>C	uc001ukx.2	-	7	1446	c.1379A>G	c.(1378-1380)AAA>AGA	p.K460R	ANKLE2_uc001uky.3_Missense_Mutation_p.K398R	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	460						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TTCCACAGATTTATTTTTGCT	0.413			NA											28	66					0	0	0.009535	0	0
RXFP2	122042	broad.mit.edu	37	13	32349457	32349457	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr13:32349457A>G	uc001utt.2	+	7	643	c.572A>G	c.(571-573)TAT>TGT	p.Y191C	RXFP2_uc010aba.2_Missense_Mutation_p.Y174C	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	191	LRR 3.|Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		ATTTGTAGATATCTCAACCAC	0.368			NA											43	241					0	0	0.01441	0	0
CUL4A	8451	broad.mit.edu	37	13	113883759	113883759	+	Splice_Site	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr13:113883759G>C	uc010tjy.1	+	6	450	c.439_splice	c.e6-1	p.I147_splice	CUL4A_uc010tjx.1_Splice_Site_p.I47_splice|CUL4A_uc010agu.2_Splice_Site|CUL4A_uc001vth.2_Splice_Site|CUL4A_uc001vtj.2_Splice_Site	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1						cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			CTGCTGGTCAGATCATGATCA	0.473			NA											13	82					0	0	0.020292	0	0
CUL4A	8451	broad.mit.edu	37	13	113897452	113897452	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr13:113897452C>T	uc010tjy.1	+	12	1217	c.1206C>T	c.(1204-1206)CCC>CCT	p.P402P	CUL4A_uc010tjx.1_Silent_p.P302P|CUL4A_uc010agu.2_Silent_p.P263P|CUL4A_uc010tjz.1_Silent_p.P81P	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	402					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			ACAAGAGACCCAACAAGCCTG	0.418			NA											17	185					0	0	0.008871	0	0
POTEG	404785	broad.mit.edu	37	14	19563533	19563533	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:19563533T>G	uc001vuz.1	+	5	1099	c.1047T>G	c.(1045-1047)CAT>CAG	p.H349Q	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	349				H -> R (in Ref. 1; AAS58868/AAS58871).						ovary(1)	1						TTTCTAGTCATCATAATGTGT	0.348			NA											26	798					0	0	0.013726	0	0
MMP14	4323	broad.mit.edu	37	14	23311752	23311752	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:23311752G>C	uc001whc.2	+	4	748	c.514G>C	c.(514-516)GAG>CAG	p.E172Q		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	172	Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TGAGGGCCATGAGAAGCAGGC	0.622			NA											10	33					0	0	0.008291	0	0
LRFN5	145581	broad.mit.edu	37	14	42360651	42360651	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:42360651C>G	uc001wvm.2	+	4	2782	c.1584C>G	c.(1582-1584)ACC>ACG	p.T528T	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	528	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGGGAGGCACCATGATTATTA	0.428			NA								HNSCC(30;0.082)			68	562					0	0	0.01441	0	0
MAP4K5	11183	broad.mit.edu	37	14	50935437	50935437	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:50935437C>A	uc001wya.2	-	10	926	c.606G>T	c.(604-606)TGG>TGT	p.W202C	MAP4K5_uc001wyb.2_Missense_Mutation_p.W202C|MAP4K5_uc010anv.1_Missense_Mutation_p.W202C	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	202	Protein kinase.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					TTCCTACTGCCCAGATATCAC	0.393			NA											15	63					8.60227e-14	9.891e-14	0.004007	1	0
TRMT5	57570	broad.mit.edu	37	14	61446167	61446167	+	Missense_Mutation	SNP	G	G	C	rs146315661		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:61446167G>C	uc001xff.3	-	2	540	c.449C>G	c.(448-450)TCC>TGC	p.S150C	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	150						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		TTTCTCAAAGGAATCATGAGT	0.373			NA											27	104					0	0	0.008361	0	0
PPP2R5E	5529	broad.mit.edu	37	14	63888788	63888788	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:63888788G>C	uc001xgd.1	-	4	969	c.379C>G	c.(379-381)CTC>GTC	p.L127V	PPP2R5E_uc010tsf.1_Missense_Mutation_p.L51V|PPP2R5E_uc010tsg.1_Missense_Mutation_p.L51V|PPP2R5E_uc001xge.2_Missense_Mutation_p.L127V|PPP2R5E_uc010tsh.1_Missense_Mutation_p.L127V|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	127					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CTAGGAGGGAGAGTTCTGAAT	0.423			NA											21	181					0	0	0.014323	0	0
AKAP5	9495	broad.mit.edu	37	14	64935712	64935712	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:64935712C>T	uc001xhd.3	+	2	978	c.600C>T	c.(598-600)AGC>AGT	p.S200S	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	200					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		CAAATGTGAGCAATAGCACAA	0.418			NA											17	76					0	0	0.010504	0	0
HSPA2	3306	broad.mit.edu	37	14	65008589	65008589	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:65008589G>T	uc001xhj.2	+	2	1098	c.1022G>T	c.(1021-1023)GGC>GTC	p.G341V	HSPA2_uc001xhk.3_Missense_Mutation_p.G341V	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	341					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GTGCTGGTGGGCGGCTCCACT	0.617	Pancreas(136;1211 1835 24894 31984 38227)		NA											7	33					0.00307968	0.00317269	0.00308	1	0
FUT8	2530	broad.mit.edu	37	14	66208847	66208847	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:66208847C>T	uc001xin.2	+	11	2644	c.1447C>T	c.(1447-1449)CAT>TAT	p.H483Y	FUT8_uc001xio.2_Missense_Mutation_p.H483Y|FUT8_uc010tsp.1_Missense_Mutation_p.H320Y|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.H483Y|FUT8_uc001xiq.2_Missense_Mutation_p.H354Y|FUT8_uc001xis.2_Missense_Mutation_p.H77Y	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	483	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GCAAACACTACATCCTGATGC	0.388			NA											32	219					0	0	0.00623	0	0
LIN52	91750	broad.mit.edu	37	14	74551687	74551687	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:74551687C>G	uc001xpp.2	+	1	32	c.22C>G	c.(22-24)CCC>GCC	p.P8A	LIN52_uc010asb.2_RNA|ALDH6A1_uc001xpo.2_5'Flank|ALDH6A1_uc010asa.2_5'Flank|ALDH6A1_uc010tuq.1_5'Flank	NM_001024674	NP_001019845	Q52LA3	LIN52_HUMAN	lin-52 homolog	8										breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00471)		GATGGCGTCTCCCACAGACGG	0.552			NA											22	227					0	0	0.012213	0	0
KIAA0317	9870	broad.mit.edu	37	14	75142464	75142464	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:75142464C>T	uc001xqb.2	-	8	1523	c.1018G>A	c.(1018-1020)GAG>AAG	p.E340K	KIAA0317_uc010tut.1_Missense_Mutation_p.E179K|KIAA0317_uc001xqc.2_Missense_Mutation_p.E340K	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	340					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		GTGTGGCACTCAGAGGGCGAG	0.547			NA											27	501					0	0	0.010818	0	0
C14orf178	283579	broad.mit.edu	37	14	78235900	78235900	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:78235900C>G	uc001xug.1	+	4	706	c.248C>G	c.(247-249)TCT>TGT	p.S83C	C14orf178_uc001xuh.1_RNA	NM_174943	NP_777603	Q8N769	CN178_HUMAN	hypothetical protein LOC283579	83										ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0273)		GTGAAAGATTCTACCTTTCTA	0.07			NA											5	17					0	0	0.014758	0	0
PPP4R4	57718	broad.mit.edu	37	14	94733329	94733329	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:94733329C>G	uc001ycs.1	+	23	2566	c.2412C>G	c.(2410-2412)GTC>GTG	p.V804V		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	804						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						CAACTTCTGTCTCAGGGTTAG	0.303			NA											8	78					0	0	0.010729	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419327	105419327	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:105419327G>A	uc010axc.1	-	7	2581	c.2461C>T	c.(2461-2463)CTG>TTG	p.L821L	AHNAK2_uc001ypx.2_Silent_p.L721L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	821						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGTCGGCCAGGGACAGGTCC	0.602			NA											26	135					0	0	0.00632	0	0
CASC5	57082	broad.mit.edu	37	15	40902476	40902476	+	Silent	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:40902476G>C	uc010bbs.1	+	6	392	c.231G>C	c.(229-231)GTG>GTC	p.V77V	CASC5_uc010ucq.1_5'UTR|CASC5_uc001zme.2_Silent_p.V77V|CASC5_uc010bbt.1_Silent_p.V77V	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	77	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGAAAATAGTGAGAAAGTCAG	0.294			NA											12	48					0	0	0.004007	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42108784	42108784	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:42108784G>C	uc001zok.3	+	14	1825	c.1539G>C	c.(1537-1539)GAG>GAC	p.E513D	MAPKBP1_uc001zoj.3_Missense_Mutation_p.E507D|MAPKBP1_uc010bcj.2_Missense_Mutation_p.E14D|MAPKBP1_uc010bci.2_Missense_Mutation_p.E507D|MAPKBP1_uc010udb.1_Missense_Mutation_p.E346D|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.E14D	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	513	WD 7.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCTGAGTGAGATGCTGAAGG	0.582			NA											5	32					0	0	0.014758	0	0
CAPN3	825	broad.mit.edu	37	15	42678468	42678468	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:42678468G>A	uc001zpn.1	+	3	789	c.483G>A	c.(481-483)GGG>GGA	p.G161G	CAPN3_uc001zpk.1_5'UTR|CAPN3_uc001zpl.1_Silent_p.G74G|CAPN3_uc010udf.1_Silent_p.G74G|CAPN3_uc010udg.1_Silent_p.G74G|CAPN3_uc001zpo.1_Silent_p.G161G|CAPN3_uc001zpp.1_Silent_p.G161G	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	161	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		ACTACGCAGGGATCTTCCACT	0.547			NA									OREG0023085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	150					0	0	0.013114	0	0
DMXL2	23312	broad.mit.edu	37	15	51792347	51792347	+	Missense_Mutation	SNP	C	C	T	rs138911498		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:51792347C>T	uc002abf.2	-	18	3299	c.3074G>A	c.(3073-3075)CGC>CAC	p.R1025H	DMXL2_uc010ufy.1_Missense_Mutation_p.R1025H|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1025	WD 8.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTTCCAGAAGCGTACTTTATT	0.363			NA											22	178					0	0	0.016522	0	0
SMAD3	4088	broad.mit.edu	37	15	67473637	67473637	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:67473637G>A	uc002aqj.2	+	6	1015	c.717G>A	c.(715-717)GAG>GAA	p.E239E	SMAD3_uc010ujr.1_Silent_p.E134E|SMAD3_uc010ujs.1_Silent_p.E195E|SMAD3_uc010ujt.1_Silent_p.E44E	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	239	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCTACTACGAGCTGAACCAGC	0.612			NA											13	85					0	0	0.004007	0	0
GLCE	26035	broad.mit.edu	37	15	69548421	69548421	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr15:69548421T>A	uc002ary.1	+	3	504	c.276T>A	c.(274-276)AAT>AAA	p.N92K		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	92	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						GGGGCTTCAATAGCAATGTGG	0.453			NA											75	410					0	0	0.01441	0	0
PARN	5073	broad.mit.edu	37	16	14645891	14645891	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr16:14645891C>T	uc010uzd.1	-	21	1609	c.1467G>A	c.(1465-1467)GAG>GAA	p.E489E	PARN_uc010uzc.1_Silent_p.E428E|PARN_uc010uze.1_Silent_p.E443E|PARN_uc010uzf.1_Silent_p.E314E	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	489					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						TCTTTACTTGCTCGGGCTGGC	0.403			NA											88	429					0	0	0.01441	0	0
ABCC1	4363	broad.mit.edu	37	16	16225762	16225762	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr16:16225762C>T	uc010bvi.2	+	27	4111	c.3936C>T	c.(3934-3936)CAC>CAT	p.H1312H	ABCC1_uc010bvj.2_Silent_p.H1253H|ABCC1_uc010bvk.2_Silent_p.H1256H|ABCC1_uc010bvl.2_Silent_p.H1312H|ABCC1_uc010bvm.2_Silent_p.H1197H|ABCC1_uc002del.3_Silent_p.H1206H	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1312	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCTCAGGCACATCAATGTCA	0.612			NA											26	187					0	0	0.008361	0	0
IL21R	50615	broad.mit.edu	37	16	27457349	27457349	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr16:27457349C>A	uc002doq.1	+	8	1040	c.807C>A	c.(805-807)GCC>GCA	p.A269A	IL21R_uc002dor.1_Silent_p.A269A|IL21R_uc002dos.1_Silent_p.A269A	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	269	Cytoplasmic (Potential).|Box 1 motif.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						AGATATGGGCCGTCCCCAGCC	0.637			NA	T	BCL6	NHL								10	51					0.00136819	0.00142385	0.013537	1	0
CES4	51716	broad.mit.edu	37	16	55806409	55806409	+	Missense_Mutation	SNP	T	T	C	rs28366434	by1000genomes	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr16:55806409T>C	uc002eik.2	+	5	711	c.260T>C	c.(259-261)GTG>GCG	p.V87A	CES4_uc010cce.2_Missense_Mutation_p.V87A	NR_003276				RecName: Full=Inactive carboxylesterase 4; AltName: Full=Placental carboxylesterase 3;          Short=PCE-3; Flags: Precursor;												0						GGAGGGTCAGTGGGAGGAGAA	0.567			NA											3	37					0	0	0.004672	0	0
KIFC3	3801	broad.mit.edu	37	16	57805461	57805461	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr16:57805461G>C	uc002emp.2	-	5	716	c.519C>G	c.(517-519)CAC>CAG	p.H173Q	KIFC3_uc010vhw.1_Missense_Mutation_p.H71Q|KIFC3_uc002emn.2_RNA|KIFC3_uc002emm.2_Missense_Mutation_p.H34Q|KIFC3_uc010vhx.1_Missense_Mutation_p.H34Q|KIFC3_uc010cdf.2_Missense_Mutation_p.H34Q|KIFC3_uc002emo.3_Missense_Mutation_p.H34Q|KIFC3_uc010vhy.1_Missense_Mutation_p.H115Q|KIFC3_uc002emq.2_Missense_Mutation_p.H173Q|KIFC3_uc010vhz.1_Missense_Mutation_p.H195Q|KIFC3_uc002emr.1_Intron|KIFC3_uc010cdg.1_RNA	NM_005550	NP_005541	Q9BVG8	KIFC3_HUMAN	kinesin family member C3 isoform 1	173	Potential.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			central_nervous_system(2)|ovary(1)	3		all_neural(199;0.224)				TCACCTGGCTGTGCTCACAAC	0.642			NA											7	50					0	0	0.001984	0	0
PELP1	27043	broad.mit.edu	37	17	4575522	4575522	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:4575522C>G	uc002fyi.3	-	16	2990	c.2764G>C	c.(2764-2766)GAA>CAA	p.E922Q	PELP1_uc010vsf.1_Missense_Mutation_p.E775Q	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	922	Glu-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						tcttcctcttcaaaatattcc	0			NA											3	4					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:7578455C>G	uc002gim.2	-	5	669	c.475G>C	c.(475-477)GCC>CCC	p.A159P	TP53_uc002gig.1_Missense_Mutation_p.A159P|TP53_uc002gih.2_Missense_Mutation_p.A159P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27P|TP53_uc010cng.1_Missense_Mutation_p.A27P|TP53_uc002gii.1_Missense_Mutation_p.A27P|TP53_uc010cnh.1_Missense_Mutation_p.A159P|TP53_uc010cni.1_Missense_Mutation_p.A159P|TP53_uc002gij.2_Missense_Mutation_p.A159P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66P|TP53_uc002gio.2_Missense_Mutation_p.A27P|TP53_uc010vug.1_Missense_Mutation_p.A120P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R158fs*11(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	162					0	0	0.006999	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8219171	8219171	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:8219171A>T	uc002glc.2	+	8	1641	c.1520A>T	c.(1519-1521)TAT>TTT	p.Y507F	ARHGEF15_uc002gld.2_Missense_Mutation_p.Y507F|ARHGEF15_uc010vuw.1_Missense_Mutation_p.Y396F	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	507	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TTCTCGGTGTATGTGGATTAT	0.597			NA											19	40					0	0	0.016522	0	0
MYH13	8735	broad.mit.edu	37	17	10212691	10212691	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:10212691T>C	uc002gmk.1	-	35	5119	c.5029A>G	c.(5029-5031)ATC>GTC	p.I1677V		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1677	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CGCTCCACGATGGCCAGCTGC	0.642			NA											6	25					0	0	0.00308	0	0
MYH1	4619	broad.mit.edu	37	17	10409227	10409227	+	Silent	SNP	A	A	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:10409227A>T	uc002gmo.2	-	19	2170	c.2076T>A	c.(2074-2076)CTT>CTA	p.L692L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	692	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GATGCAGGACAAGCTCATGCT	0.478			NA											18	136					0	0	0.008871	0	0
CCDC144NL	339184	broad.mit.edu	37	17	20799042	20799042	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:20799042G>T	uc002gyf.2	-	1	412	c.292C>A	c.(292-294)CAC>AAC	p.H98N	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	98											0						GCCAAGACGTGCTCCACCCCA	0.642			NA											29	191					1.05386e-31	1.31518e-31	0.01441	1	0
LIG3	3980	broad.mit.edu	37	17	33328387	33328387	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:33328387G>C	uc002hik.1	+	17	2551	c.2443G>C	c.(2443-2445)GAC>CAC	p.D815H	LIG3_uc002hij.2_Missense_Mutation_p.D815H	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	815					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	AGATGATAAGGACTGGAAATC	0.537			NA						Other_BER_factors					3	90					0	0	0.014758	0	0
TADA2A	6871	broad.mit.edu	37	17	35830621	35830621	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:35830621G>A	uc002hnt.2	+	13	1170	c.1013G>A	c.(1012-1014)CGC>CAC	p.R338H	TADA2A_uc002hnv.2_Missense_Mutation_p.R338H|TADA2A_uc002hnw.2_Missense_Mutation_p.R237H|TADA2A_uc010cvb.2_Missense_Mutation_p.R134H	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	338					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						CAGTGGCTCCGCCGGCAAGCT	0.517			NA											6	239					0	0	0.001984	0	0
RPL19	6143	broad.mit.edu	37	17	37358692	37358692	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:37358692G>T	uc002hrq.1	+	3	297	c.235G>T	c.(235-237)GGT>TGT	p.G79C	RPL19_uc002hrr.1_Missense_Mutation_p.G77C	NM_000981	NP_000972	P84098	RL19_HUMAN	ribosomal protein L19	79					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CATGGGCATAGGTAAGTGTGG	0.512			NA											17	78					7.87624e-14	9.09025e-14	0.016522	1	0
MED1	5469	broad.mit.edu	37	17	37564803	37564803	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:37564803G>A	uc002hrv.3	-	17	3883	c.3671C>T	c.(3670-3672)CCT>CTT	p.P1224L	MED1_uc010wee.1_Missense_Mutation_p.P1052L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1224	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGAACTGATAGGGGACTTGGC	0.507	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			11	48					0	0	0.008291	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39191008	39191009	+	Missense_Mutation	DNP	GG	GG	AT	rs71300033		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:39191008_39191009GG>AT	uc002hvv.2	-	1	99_100	c.65_66CC>AT	c.(64-66)TCC>TAT	p.S22Y		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	22						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGCAGCAGCTGGAGCCGCATGT	0.589			NA											8	94					0	0	0.004672	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39191048	39191048	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:39191048C>G	uc002hvv.2	-	1	60	c.26G>C	c.(25-27)TGT>TCT	p.C9S		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	9						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGGATATCCACAGAAGCTGGT	0.592			NA											13	96					0	0	0.006122	0	0
KRT38	8687	broad.mit.edu	37	17	39595502	39595503	+	Nonsense_Mutation	DNP	CC	CC	AG			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:39595502_39595503CC>AG	uc002hwq.1	-	3	1107_1108	c.684_685GG>CT	c.(682-687)CAGGAG>CACTAG	p.228_229QE>H*		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	228_229	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				TTCAGGGACTCCTGCTGGGCCT	0.658			NA											14	84					0	0	0.004672	0	0
BRIP1	83990	broad.mit.edu	37	17	59760881	59760881	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:59760881T>G	uc002izk.1	-	20	3667	c.3526A>C	c.(3526-3528)ATA>CTA	p.I1176L		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1176					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ACTTCTTTTATAGTTCTAATT	0.318			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				16	45					0	0	0.006122	0	0
SRP68	6730	broad.mit.edu	37	17	74046574	74046574	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:74046574C>G	uc002jqk.1	-	9	1047	c.1012G>C	c.(1012-1014)GAA>CAA	p.E338Q	SRP68_uc010wsu.1_Missense_Mutation_p.E237Q|SRP68_uc002jql.1_Missense_Mutation_p.E300Q|SRP68_uc002jqj.1_5'UTR	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	338					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						AGCATTGATTCAAACAGGCGC	0.527			NA											32	170					0	0	0.005524	0	0
SRP68	6730	broad.mit.edu	37	17	74046604	74046604	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:74046604C>A	uc002jqk.1	-	9	1017	c.982G>T	c.(982-984)GAA>TAA	p.E328*	SRP68_uc010wsu.1_Nonsense_Mutation_p.E227*|SRP68_uc002jql.1_Nonsense_Mutation_p.E290*|SRP68_uc002jqj.1_5'UTR	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	328					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding	p.E328K(1)		ovary(1)	1						TCTTCGCTTTCAGCCTAAACA	0.512			NA											24	128					1.17739e-12	1.34372e-12	0.005443	1	0
CIDEA	1149	broad.mit.edu	37	18	12274208	12274208	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr18:12274208C>A	uc002kqt.3	+	4	512	c.447C>A	c.(445-447)GCC>GCA	p.A149A	CIDEA_uc002kqu.3_Silent_p.A183A|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	149					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						ACGTGAAGGCCACCATGTATG	0.592			NA											33	151					6.53348e-20	7.89676e-20	0.017118	1	0
DSG1	1828	broad.mit.edu	37	18	28934418	28934418	+	Silent	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr18:28934418T>A	uc002kwp.2	+	15	2471	c.2259T>A	c.(2257-2259)CCT>CCA	p.P753P	DSG1_uc010xbp.1_Silent_p.P112P	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	753	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CCCTGGGACCTAAATTTAAGA	0.473			NA											61	271					0	0	0.01441	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143772	55143772	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr18:55143772C>G	uc002lgo.2	+	2	1364	c.1332C>G	c.(1330-1332)ATC>ATG	p.I444M		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	444	Homeobox.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TCTTCGCCATCTTCAAGGAGA	0.527			NA											18	73					0	0	0.006122	0	0
CDH20	28316	broad.mit.edu	37	18	59212284	59212284	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr18:59212284G>T	uc010dps.1	+	9	1567	c.1555G>T	c.(1555-1557)GAC>TAC	p.D519Y	CDH20_uc002lif.2_Missense_Mutation_p.D513Y	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	519	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GAGTGCGGTGGACCAAGATGA	0.512			NA											37	215					2.2871e-25	2.81983e-25	0.007835	1	0
XAB2	56949	broad.mit.edu	37	19	7692716	7692716	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:7692716G>A	uc002mgx.2	-	3	248	c.222C>T	c.(220-222)TAC>TAT	p.Y74Y	uc010dvi.1_5'Flank	NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	74	HAT 2.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						GCGCCTTCAGGTATCGGTACC	0.552			NA						Direct_reversal_of_damage|NER					7	47					0	0	0.00308	0	0
ARRDC2	27106	broad.mit.edu	37	19	18120660	18120660	+	Missense_Mutation	SNP	G	G	A	rs147746417		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:18120660G>A	uc002nhv.2	+	5	804	c.661G>A	c.(661-663)GTG>ATG	p.V221M	ARRDC2_uc002nhu.2_Missense_Mutation_p.V216M	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	221										pancreas(1)	1						TCGGGCAGCCGTGGTGCAGAC	0.682			NA											3	33					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	19	23405580	23405580	+	Silent	SNP	T	T	C	rs10412126	by1000genomes	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:23405580T>C	uc010xri.1	-	4	1585	c.1467A>G	c.(1465-1467)CTA>CTG	p.L489L						SubName: Full=cDNA FLJ56866, moderately similar to Zinc finger protein 43;												NA						GGTGTGAGGATAGGTTAAAAG	0.383			NA											3	62					0	0	0.009096	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767488	31767488	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:31767488G>T	uc002nsy.3	-	2	3276	c.3211C>A	c.(3211-3213)CAC>AAC	p.H1071N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1071					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TACAGAAGGTGGTCTTCCGGA	0.473			NA											17	127					8.34094e-07	8.89121e-07	0.008871	1	0
KIAA0355	9710	broad.mit.edu	37	19	34833289	34833289	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:34833289C>G	uc002nvd.3	+	10	3309	c.2450C>G	c.(2449-2451)ACC>AGC	p.T817S		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	817										ovary(1)	1	Esophageal squamous(110;0.162)					AGAAATAACACCTGGCCCAAC	0.522			NA											6	303					0	0	0.004482	0	0
ZNF568	374900	broad.mit.edu	37	19	37441464	37441464	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:37441464G>C	uc002ofc.2	+	7	1924	c.1409G>C	c.(1408-1410)GGA>GCA	p.G470A	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.G394A|ZNF568_uc010efe.2_Missense_Mutation_p.G394A|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCACACTGGAGAGAAACCT	0.398			NA											14	67					0	0	0.00499	0	0
ZNF571	51276	broad.mit.edu	37	19	38055625	38055625	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:38055625G>A	uc002ogt.2	-	4	1806	c.1705C>T	c.(1705-1707)CGT>TGT	p.R569C	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Missense_Mutation_p.R569C	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	569	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGAGCCACGACTAAAGGCC	0.443			NA											58	268					0	0	0.01441	0	0
HIPK4	147746	broad.mit.edu	37	19	40886395	40886395	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:40886395G>T	uc002onp.2	-	3	1788	c.1503C>A	c.(1501-1503)TTC>TTA	p.F501L		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	501						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGAGGTTGCTGAAGTTGGAGT	0.667			NA											25	212					2.41591e-17	2.86365e-17	0.004656	1	0
CCDC97	90324	broad.mit.edu	37	19	41828552	41828552	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:41828552G>A	uc002oqg.2	+	5	1086	c.964G>A	c.(964-966)GAG>AAG	p.E322K	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	322											0						GGCACGGGATGAGGAGGAGAG	0.627			NA											63	442					0	0	0.01441	0	0
CCDC97	90324	broad.mit.edu	37	19	41828555	41828555	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:41828555G>A	uc002oqg.2	+	5	1089	c.967G>A	c.(967-969)GAG>AAG	p.E323K	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	323											0						ACGGGATGAGGAGGAGAGGTA	0.632			NA											62	434					0	0	0.01441	0	0
PRR19	284338	broad.mit.edu	37	19	42813884	42813884	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:42813884C>T	uc002oti.2	+	2	526	c.148C>T	c.(148-150)CGG>TGG	p.R50W	PRR19_uc002oth.1_Missense_Mutation_p.R50W|PRR19_uc002otj.2_Missense_Mutation_p.R50W	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	50											0		Prostate(69;0.00682)				TGTGGCCATTCGGGATCCACC	0.637			NA											6	28					0	0	0.004482	0	0
ZNF225	7768	broad.mit.edu	37	19	44622435	44622435	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:44622435T>A	uc002oyj.1	+	3	353	c.110T>A	c.(109-111)ATG>AAG	p.M37K	ZNF225_uc010eje.1_5'UTR|ZNF225_uc010ejf.1_Missense_Mutation_p.M37K	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CGAGAAGTGATGCTGGAGAAC	0.537			NA											128	766					0	0	0.01441	0	0
ZFP112	7771	broad.mit.edu	37	19	44831777	44831777	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:44831777G>A	uc010ejj.2	-	5	2664	c.2551C>T	c.(2551-2553)CAC>TAC	p.H851Y	ZFP112_uc002ozc.3_Missense_Mutation_p.H845Y|ZFP112_uc010xwy.1_Missense_Mutation_p.H868Y|ZFP112_uc010xwz.1_Missense_Mutation_p.H850Y	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	851	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ACTCTCTGGTGAGCCTGAAGA	0.458	Melanoma(53;975 1202 7512 15993 27273)		NA											42	375					0	0	0.01441	0	0
EML2	24139	broad.mit.edu	37	19	46133262	46133262	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:46133262G>A	uc002pcn.2	-	7	588	c.553C>T	c.(553-555)CAC>TAC	p.H185Y	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Missense_Mutation_p.H69Y|EML2_uc010xxl.1_Missense_Mutation_p.H332Y|EML2_uc010xxm.1_Missense_Mutation_p.H386Y|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Missense_Mutation_p.H185Y|EML2_uc010ekj.2_Missense_Mutation_p.H185Y|EML2_uc010ekk.1_RNA	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	185	WD 2.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GAGAGCATGTGATCATTGGAT	0.582			NA											15	80					0	0	0.004007	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51633160	51633160	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:51633160G>T	uc002pvu.2	+	7	1283	c.1216G>T	c.(1216-1218)GAA>TAA	p.E406*	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	406	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GCCCCTGACTGAACCTTGGGC	0.478			NA											24	100					8.88839e-20	1.06591e-19	0.010818	1	0
ZNF525	170958	broad.mit.edu	37	19	53884192	53884192	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:53884192G>T	uc010eqn.2	+	4	445	c.252G>T	c.(250-252)ATG>ATT	p.M84I	ZNF525_uc002qbl.2_Intron|ZNF765_uc010ydx.1_Intron	NR_003699				Homo sapiens cDNA FLJ39718 fis, clone SMINT2013695.												0						AAAAATTGATGGGTAGTACAG	0.373			NA											19	138					8.34094e-07	8.89121e-07	0.008871	1	0
NLRP2	55655	broad.mit.edu	37	19	55481465	55481465	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:55481465T>A	uc002qij.2	+	2	168	c.82T>A	c.(82-84)TAT>AAT	p.Y28N	NLRP2_uc010yfp.1_Missense_Mutation_p.Y28N|NLRP2_uc010esn.2_Missense_Mutation_p.Y28N|NLRP2_uc010eso.2_Missense_Mutation_p.Y28N|NLRP2_uc010esp.2_Missense_Mutation_p.Y28N	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	28	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CAAGTTCAAGTATCTGATCAC	0.557			NA											14	126					0	0	0.003163	0	0
NLRP8	126205	broad.mit.edu	37	19	56467063	56467063	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:56467063G>C	uc002qmh.2	+	3	1710	c.1639G>C	c.(1639-1641)GGA>CGA	p.G547R	NLRP8_uc010etg.2_Missense_Mutation_p.G547R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	547						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGTCCCAGAGGAAGCAAAAG	0.468			NA											20	119					0	0	0.010504	0	0
ZNF444	55311	broad.mit.edu	37	19	56669884	56669884	+	Missense_Mutation	SNP	G	G	A	rs61736532	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:56669884G>A	uc002qmm.2	+	4	686	c.319G>A	c.(319-321)GGG>AGG	p.G107R	ZNF444_uc002qmn.1_Missense_Mutation_p.G107R	NM_018337	NP_060807	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	107					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		CTCCCCCGATGGGTCGTCAGC	0.597			NA											4	89					0	0	0.001168	0	0
PEG3	5178	broad.mit.edu	37	19	57327147	57327147	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:57327147T>A	uc002qnu.2	-	7	3014	c.2663A>T	c.(2662-2664)AAT>ATT	p.N888I	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.N859I|PEG3_uc002qnv.2_Missense_Mutation_p.N888I|PEG3_uc002qnw.2_Missense_Mutation_p.N764I|PEG3_uc002qnx.2_Missense_Mutation_p.N762I|PEG3_uc010etr.2_Missense_Mutation_p.N888I	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	888					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAGTTGCGATTCTTACTGCC	0.448			NA											30	179					0	0	0.009535	0	0
ZIM3	114026	broad.mit.edu	37	19	57646337	57646337	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:57646337G>A	uc002qnz.1	-	5	1754	c.1368C>T	c.(1366-1368)TTC>TTT	p.F456F		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	456	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCTGTCAGCGAAGGCTTTAC	0.403			NA											7	274					0	0	0.008291	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699059	17699059	+	Silent	SNP	A	A	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:17699059A>T	uc002rcl.1	-	1	648	c.624T>A	c.(622-624)ATT>ATA	p.I208I	RAD51AP2_uc010exn.1_Silent_p.I199I	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	208										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ATCTGTTCTTAATTTCATGAA	0.308			NA											23	99					0	0	0.004656	0	0
C2orf39	92749	broad.mit.edu	37	2	26678013	26678013	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:26678013A>T	uc002rhg.2	+	16	2152	c.2078A>T	c.(2077-2079)CAG>CTG	p.Q693L		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	693	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCTGACCCAGAGGGCCAAG	0.562			NA											40	119					0	0	0.01441	0	0
ALK	238	broad.mit.edu	37	2	29498008	29498008	+	Silent	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:29498008G>T	uc002rmy.2	-	11	2905	c.1998C>A	c.(1996-1998)CCC>CCA	p.P666P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	666	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.P666L(1)	NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AATTTTCCCCGGGTTTCAGCT	0.463			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				23	45					2.27525e-19	2.71791e-19	0.021523	1	0
TTC7A	57217	broad.mit.edu	37	2	47221537	47221537	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:47221537G>A	uc002rvo.2	+	7	1253	c.885G>A	c.(883-885)CTG>CTA	p.L295L	TTC7A_uc002rvm.2_Silent_p.L261L|TTC7A_uc002rvn.1_Silent_p.L176L|TTC7A_uc010fbb.2_Silent_p.L295L|TTC7A_uc010fbc.2_Intron|TTC7A_uc002rvp.2_Silent_p.L176L|TTC7A_uc002rvq.2_Silent_p.L35L|TTC7A_uc002rvr.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	295							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGCACTCCCTGAGTGAGGAGT	0.632			NA											6	239					0	0	0.00308	0	0
DYSF	8291	broad.mit.edu	37	2	71839841	71839841	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:71839841G>T	uc002sie.2	+	39	4614	c.4238G>T	c.(4237-4239)CGC>CTC	p.R1413L	DYSF_uc010feg.2_Missense_Mutation_p.R1444L|DYSF_uc010feh.2_Missense_Mutation_p.R1399L|DYSF_uc002sig.3_Missense_Mutation_p.R1399L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1413L|DYSF_uc010fef.2_Missense_Mutation_p.R1430L|DYSF_uc010fei.2_Missense_Mutation_p.R1430L|DYSF_uc010fek.2_Missense_Mutation_p.R1431L|DYSF_uc010fej.2_Missense_Mutation_p.R1400L|DYSF_uc010fel.2_Missense_Mutation_p.R1400L|DYSF_uc010feo.2_Missense_Mutation_p.R1445L|DYSF_uc010fem.2_Missense_Mutation_p.R1414L|DYSF_uc010fen.2_Missense_Mutation_p.R1431L|DYSF_uc002sif.2_Missense_Mutation_p.R1414L|DYSF_uc010yqy.1_Missense_Mutation_p.R294L|DYSF_uc010yqz.1_Missense_Mutation_p.R153L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1413	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CAGTTTGGCCGCCGGCCTGTG	0.647			NA											16	19					5.45727e-16	6.41909e-16	0.008361	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745477	77745477	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:77745477G>A	uc002snr.2	-	3	1933	c.1518C>T	c.(1516-1518)TGC>TGT	p.C506C	LRRTM4_uc002snq.2_Silent_p.C506C|LRRTM4_uc002sns.2_Silent_p.C506C|LRRTM4_uc002snt.2_Silent_p.C507C	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	506	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TGGTATATGTGCAGGGCCCAG	0.448			NA											9	49					0	0	0.016723	0	0
GPR148	344561	broad.mit.edu	37	2	131486979	131486979	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:131486979C>A	uc002trv.1	+	1	257	c.255C>A	c.(253-255)CAC>CAA	p.H85Q		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	85	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					AGGAGCCCCACTACCTGCTCC	0.632			NA											8	80					5.4927e-09	5.97965e-09	0.004482	1	0
LRP1B	53353	broad.mit.edu	37	2	141299477	141299477	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:141299477A>G	uc002tvj.1	-	44	8230	c.7258T>C	c.(7258-7260)TGG>CGG	p.W2420R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2420	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTCCGACCAGAATATATAA	0.383	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			47	78					0	0	0.01441	0	0
TBR1	10716	broad.mit.edu	37	2	162273111	162273111	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:162273111G>C	uc002ubw.1	+	1	492	c.190G>C	c.(190-192)GAT>CAT	p.D64H	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	64						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GAATCAGTCAGATACAGACAA	0.483			NA											9	124					0	0	0.004482	0	0
PDE11A	50940	broad.mit.edu	37	2	178762821	178762821	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:178762821G>A	uc002ulq.2	-	4	1584	c.1266C>T	c.(1264-1266)CGC>CGT	p.R422R	PDE11A_uc002ulr.2_Silent_p.R172R|PDE11A_uc002uls.1_Silent_p.R64R|PDE11A_uc002ult.1_Silent_p.R172R|PDE11A_uc002ulu.1_Silent_p.R64R	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	422	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			AAACAGAACAGCGTTCACATT	0.373			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				20	197					0	0	0.01892	0	0
DNAH7	56171	broad.mit.edu	37	2	196866436	196866436	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:196866436G>A	uc002utj.3	-	11	1237	c.1136C>T	c.(1135-1137)TCC>TTC	p.S379F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	379	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATCTTGCATGGAGACTAAAGT	0.378			NA											57	189					0	0	0.01441	0	0
CCDC150	284992	broad.mit.edu	37	2	197531457	197531457	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:197531457G>C	uc002utp.1	+	7	912	c.777G>C	c.(775-777)CAG>CAC	p.Q259H	CCDC150_uc002uto.1_Missense_Mutation_p.Q259H|CCDC150_uc010zgq.1_Intron|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	259	Potential.										0						ACATTTTGCAGCAAAACTGCA	0.378			NA											4	27					0	0	0.001168	0	0
CPS1	1373	broad.mit.edu	37	2	211518752	211518752	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:211518752C>T	uc002vee.3	+	29	3616	c.3484C>T	c.(3484-3486)CAC>TAC	p.H1162Y	CPS1_uc010fur.2_Missense_Mutation_p.H1168Y|CPS1_uc010fus.2_Missense_Mutation_p.H711Y	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1162	ATP-grasp 2.			EH -> AT (in Ref. 1; BAA14328).	carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTGACAGGAGCACCCAGTGGT	0.433			NA											84	186					0	0	0.01441	0	0
PRR21	643905	broad.mit.edu	37	2	240982137	240982137	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:240982137G>A	uc010zod.1	-	1	263	c.263C>T	c.(262-264)TCA>TTA	p.S88L		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	88	Pro-rich.									ovary(1)|skin(1)	2						AGGCATGGATGAAGGACTGTG	0.607			NA											99	248					0	0	0.01441	0	0
STK25	10494	broad.mit.edu	37	2	242438432	242438432	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr2:242438432T>A	uc002wbm.2	-	6	1014	c.743A>T	c.(742-744)GAG>GTG	p.E248V	STK25_uc002wbk.2_Missense_Mutation_p.E67V|STK25_uc002wbl.2_Missense_Mutation_p.E67V|STK25_uc002wbn.2_Missense_Mutation_p.E248V|STK25_uc002wbo.2_Missense_Mutation_p.E171V|STK25_uc010zos.1_Missense_Mutation_p.E154V|STK25_uc010zot.1_Missense_Mutation_p.E174V|STK25_uc002wbp.2_Missense_Mutation_p.E248V|STK25_uc010fzo.2_Missense_Mutation_p.E171V|STK25_uc010zou.1_Missense_Mutation_p.E154V|STK25_uc010zov.1_Missense_Mutation_p.E154V	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	248	Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		GAGGCAGGCCTCCACGAACTC	0.637	NSCLC(99;1100 1566 7679 28647 48345)		NA											3	10					0	0	0.004672	0	0
TGM3	7053	broad.mit.edu	37	20	2290900	2290900	+	Silent	SNP	G	G	A	rs140997555		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr20:2290900G>A	uc002wfx.3	+	3	355	c.258G>A	c.(256-258)GCG>GCA	p.A86A		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	86					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GCTGGAGTGCGGTGCTTCAGG	0.562			NA											70	234					0	0	0.01441	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990047	39990047	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr20:39990047C>T	uc002xjy.1	-	4	2386	c.2162G>A	c.(2161-2163)AGA>AAA	p.R721K		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	721						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CAGGCCCTCTCTGGGCCTCAG	0.672			NA											9	15					0	0	0.004482	0	0
MOCS3	27304	broad.mit.edu	37	20	49575810	49575810	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr20:49575810C>T	uc002xvy.1	+	1	448	c.431C>T	c.(430-432)TCG>TTG	p.S144L	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	144					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GCCGCCGCCTCGCTGCGCCGC	0.637			NA											12	45					0	0	0.010504	0	0
DOK5	55816	broad.mit.edu	37	20	53205055	53205055	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr20:53205055C>G	uc002xwy.2	+	3	428	c.208C>G	c.(208-210)CGA>GGA	p.R70G	DOK5_uc010gin.2_5'UTR|DOK5_uc002xwz.2_5'UTR	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5	70	PH.						insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			GAACGTAGCTCGATTGCCAAA	0.408			NA											10	699					0	0	0.016723	0	0
PCK1	5105	broad.mit.edu	37	20	56138667	56138667	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr20:56138667C>A	uc002xyn.3	+	6	1008	c.845C>A	c.(844-846)GCC>GAC	p.A282D	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	282					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TACCTGGCGGCCGCATTTCCC	0.557			NA											20	35					1.64113e-05	1.73734e-05	0.010504	1	0
GRIK1	2897	broad.mit.edu	37	21	30949386	30949386	+	Silent	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr21:30949386T>A	uc002yno.1	-	14	2492	c.2028A>T	c.(2026-2028)GTA>GTT	p.V676V	GRIK1_uc002ynn.2_Silent_p.V661V|GRIK1_uc011acs.1_Silent_p.V676V|GRIK1_uc011act.1_Silent_p.V537V	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	676	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCATTCTCTCTACTGTCAAGA	0.453			NA											17	125					0	0	0.00499	0	0
DSCAM	1826	broad.mit.edu	37	21	41741116	41741116	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr21:41741116C>T	uc002yyq.1	-	4	1017	c.565G>A	c.(565-567)GAA>AAA	p.E189K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	189	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AATCCATCTTCATTCTGTACA	0.428	Melanoma(134;970 1778 1785 21664 32388)		NA											9	75					0	0	0.004482	0	0
P2RX6	9127	broad.mit.edu	37	22	21377428	21377428	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr22:21377428C>A	uc010gsu.1	+	6	579	c.579C>A	c.(577-579)GCC>GCA	p.A193A	P2RX6_uc002ztz.2_Silent_p.A167A|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	193	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TGGCCCAGGCCCAGAACTTCA	0.582			NA											19	57					1.50039e-11	1.6997e-11	0.012319	1	0
CSPG5	10675	broad.mit.edu	37	3	47610668	47610668	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:47610668T>C	uc003crp.3	-	4	1608	c.1432A>G	c.(1432-1434)ACC>GCC	p.T478A	CSPG5_uc003crn.2_Missense_Mutation_p.T340A|CSPG5_uc003cro.3_Missense_Mutation_p.T478A|CSPG5_uc011bbb.1_Missense_Mutation_p.T340A	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	478	Cytoplasmic (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCGGCAATGGTGGAGAGGGAG	0.498			NA											12	51					0	0	0.020292	0	0
SLC9A10	285335	broad.mit.edu	37	3	111870756	111870756	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:111870756C>A	uc003dyu.2	-	28	3694	c.3472G>T	c.(3472-3474)GGG>TGG	p.G1158W	SLC9A10_uc011bhu.1_Missense_Mutation_p.G421W|SLC9A10_uc010hqc.2_Missense_Mutation_p.G1110W	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1158					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						AACTTTGTCCCCAGCAGGGAG	0.502			NA											73	176					2.75442e-36	3.47986e-36	0.01441	1	0
SLC35A5	55032	broad.mit.edu	37	3	112299565	112299565	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:112299565A>G	uc003dze.2	+	6	846	c.601A>G	c.(601-603)AGA>GGA	p.R201G		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	201						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						TGAGTGTCCCAGAAAAGACAA	0.453			NA											21	175					0	0	0.016522	0	0
ZDHHC23	254887	broad.mit.edu	37	3	113673059	113673059	+	Missense_Mutation	SNP	C	C	T	rs147787442		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:113673059C>T	uc003eau.2	+	3	973	c.674C>T	c.(673-675)CCT>CTT	p.P225L	ZDHHC23_uc003eav.2_Missense_Mutation_p.P219L	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	225						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						AAAGGGTTCCCTGGGGCAGAC	0.572			NA											5	131					0	0	0.014758	0	0
ATR	545	broad.mit.edu	37	3	142171996	142171996	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:142171996C>T	uc003eux.3	-	46	7857	c.7735G>A	c.(7735-7737)GAA>AAA	p.E2579K	ATR_uc003euy.1_Missense_Mutation_p.E465K	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2579					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCTCCAGTTTCATTCAGTGGC	0.368			NA						Other_conserved_DNA_damage_response_genes					34	82					0	0	0.00874	0	0
IGSF10	285313	broad.mit.edu	37	3	151164737	151164737	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:151164737C>A	uc011bod.1	-	4	3032	c.3032G>T	c.(3031-3033)GGG>GTG	p.G1011V		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1011					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTCTGCCTCCCAAAGCGTCT	0.498			NA											29	160					1.08312e-15	1.26433e-15	0.009535	1	0
GHSR	2693	broad.mit.edu	37	3	172165759	172165759	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:172165759G>T	uc003fib.1	-	1	445	c.445C>A	c.(445-447)CTC>ATC	p.L149I	GHSR_uc011bpv.1_Missense_Mutation_p.L149I	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	149	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TTGGCCCGGAGTGGGAAGCAG	0.617	Esophageal Squamous(93;641 1401 20883 29581 34638)		NA											80	91					3.48759e-61	4.4427e-61	0.01441	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	Colon(199;1504 1750 3362 26421 31210 32040)	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			28	21					0	0	0.010818	0	0
MAEA	10296	broad.mit.edu	37	4	1309203	1309203	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:1309203G>A	uc003gda.2	+	3	301	c.271G>A	c.(271-273)GCC>ACC	p.A91T	MAEA_uc010ibs.1_Missense_Mutation_p.A91T|MAEA_uc003gdb.2_Missense_Mutation_p.A91T|MAEA_uc011bvb.1_Intron|MAEA_uc003gdc.2_Missense_Mutation_p.A91T|MAEA_uc003gdd.2_RNA|MAEA_uc011bvc.1_Missense_Mutation_p.A90T|MAEA_uc011bvd.1_Missense_Mutation_p.A43T|MAEA_uc010ibt.2_5'UTR	NM_001017405	NP_001017405	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher isoform 1	91	Extracellular and involved in cell to cell contact.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			ATCCATCCAGGCCGAGGACGA	0.662			NA											14	48					0	0	0.003163	0	0
GABRA2	2555	broad.mit.edu	37	4	46314600	46314600	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:46314600T>G	uc003gxc.3	-	4	1062	c.389A>C	c.(388-390)AAT>ACT	p.N130T	GABRA2_uc010igc.2_Missense_Mutation_p.N130T|GABRA2_uc011bzc.1_Missense_Mutation_p.N75T|GABRA2_uc003gxe.2_Missense_Mutation_p.N130T	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	130	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTTTTCCCATTGTGAAAAAA	0.353			NA											34	238					0	0	0.005524	0	0
LPHN3	23284	broad.mit.edu	37	4	62812790	62812790	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:62812790A>C	uc010ihh.2	+	13	2547	c.2374A>C	c.(2374-2376)AAC>CAC	p.N792H	LPHN3_uc003hcq.3_Missense_Mutation_p.N792H|LPHN3_uc003hct.2_Missense_Mutation_p.N185H	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	779	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGAGTTCAGTAACAAGGTTTA	0.348			NA											29	280					0	0	0.008361	0	0
HELQ	113510	broad.mit.edu	37	4	84352854	84352854	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:84352854C>T	uc003hom.2	-	11	2437	c.2258G>A	c.(2257-2259)GGA>GAA	p.G753E	HELQ_uc010ikb.2_Missense_Mutation_p.G686E|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	753	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						TGTTTGGATTCCCTTGGTGAA	0.308			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					14	49					0	0	0.007413	0	0
FAM13A	10144	broad.mit.edu	37	4	89660226	89660226	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:89660226C>T	uc003hse.1	-	20	2725	c.2517G>A	c.(2515-2517)CGG>CGA	p.R839R	FAM13A_uc011cdp.1_5'Flank|FAM13A_uc003hsa.1_Silent_p.R310R|FAM13A_uc003hsb.1_Silent_p.R513R|FAM13A_uc003hsd.1_Silent_p.R513R|FAM13A_uc003hsc.1_Silent_p.R499R|FAM13A_uc011cdq.1_Silent_p.R485R|FAM13A_uc003hsf.1_Silent_p.R425R|FAM13A_uc003hsg.1_Silent_p.R310R	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	839					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GTTTGACCAGCCGGTACCTGT	0.507			NA											9	81					0	0	0.008291	0	0
INTS12	57117	broad.mit.edu	37	4	106616825	106616825	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:106616825C>G	uc003hxw.2	-	4	415	c.157G>C	c.(157-159)GAT>CAT	p.D53H	INTS12_uc010ilr.2_Missense_Mutation_p.D53H	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	53					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GGCTCCACATCCTAAAAGATG	0.294			NA											15	184					0	0	0.004007	0	0
SPATA5	166378	broad.mit.edu	37	4	123900467	123900467	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:123900467C>G	uc003iez.3	+	10	1868	c.1795C>G	c.(1795-1797)CTG>GTG	p.L599V	SPATA5_uc003iey.2_Missense_Mutation_p.L598V	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	599					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GAAGATTACTCTGAAGGATTT	0.443			NA											96	267					0	0	0.01441	0	0
GYPA	2993	broad.mit.edu	37	4	145038046	145038046	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:145038046C>G	uc003ijo.3	-	5	434	c.318G>C	c.(316-318)ACG>ACC	p.T106T	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Silent_p.T73T|GYPA_uc003ijp.3_Silent_p.T74T|GYPA_uc010ioq.2_Silent_p.T93T|GYPA_uc010ior.2_Silent_p.T41T|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	106	Helical.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					TTAAGAGGATCGTTCCAATAA	0.358			NA											6	237					0	0	0.004482	0	0
SORBS2	8470	broad.mit.edu	37	4	186544260	186544260	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr4:186544260T>A	uc003iyl.2	-	13	3169	c.2311A>T	c.(2311-2313)AGG>TGG	p.R771W	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.R871W|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.R675W|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.R885W|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	771						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GATGAGTTCCTCTCGGGAACA	0.562	Esophageal Squamous(153;41 2433 9491 36028)		NA											4	120					0	0	0.001984	0	0
CDH12	1010	broad.mit.edu	37	5	21751993	21751993	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:21751993G>A	uc010iuc.2	-	12	2696	c.2238C>T	c.(2236-2238)TCC>TCT	p.S746S	CDH12_uc011cno.1_Silent_p.S706S|CDH12_uc003jgk.2_Silent_p.S746S|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	746	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ACTCTGCCACGGACCCACTCC	0.512			NA								HNSCC(59;0.17)			43	161					0	0	0.01441	0	0
UGT3A2	167127	broad.mit.edu	37	5	36037956	36037956	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:36037956T>C	uc003jjz.1	-	6	1331	c.1238A>G	c.(1237-1239)AAG>AGG	p.K413R	UGT3A2_uc011cos.1_Missense_Mutation_p.K379R|UGT3A2_uc011cot.1_Missense_Mutation_p.K111R	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	413	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTGAGCTTCTTTAACTGAAT	0.463			NA											96	506					0	0	0.01441	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54649065	54649065	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:54649065G>A	uc003jpy.3	+	14	1767	c.1501G>A	c.(1501-1503)GCC>ACC	p.A501T	SKIV2L2_uc011cqi.1_Missense_Mutation_p.A400T	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	501	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				ATTTACAAATGCCCGCAAATT	0.323	Melanoma(2;92 134 23744 29976 33782)		NA											9	75					0	0	0.008291	0	0
POLK	51426	broad.mit.edu	37	5	74865234	74865234	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:74865234G>A	uc003kdw.2	+	4	421	c.325G>A	c.(325-327)GAT>AAT	p.D109N	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kdz.2_Missense_Mutation_p.D109N|POLK_uc003kea.2_Missense_Mutation_p.D109N|POLK_uc003keb.2_Missense_Mutation_p.D109N|POLK_uc010izq.2_Missense_Mutation_p.D109N|POLK_uc003kec.2_Missense_Mutation_p.D19N|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.D19N|POLK_uc003kee.2_Missense_Mutation_p.D109N|POLK_uc003kef.2_Missense_Mutation_p.D19N	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	109	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		CATTGACATGGATGCTTTCTA	0.343			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	112					0	0	0.004007	0	0
POC5	134359	broad.mit.edu	37	5	74981288	74981288	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:74981288T>G	uc003keh.3	-	10	1348	c.1151A>C	c.(1150-1152)AAA>ACA	p.K384T	POC5_uc010izu.2_Missense_Mutation_p.K267T|POC5_uc003keg.3_Missense_Mutation_p.K359T	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	384					cell cycle	centriole				lung(1)	1						CTCTTCCTTTTTATTATTTGT	0.383			NA											16	202					0	0	0.008871	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80608439	80608439	+	Silent	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:80608439G>T	uc003khj.2	+	6	907	c.774G>T	c.(772-774)CCG>CCT	p.P258P	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.P258P|ZCCHC9_uc003khi.2_Silent_p.P258P	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	258							nucleic acid binding|zinc ion binding	p.P258L(1)		ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		TACCTAAACCGCAAAAACCCA	0.388			NA											27	107					2.12542e-12	2.41668e-12	0.00632	1	0
GPR98	84059	broad.mit.edu	37	5	89943510	89943510	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:89943510C>G	uc003kju.2	+	17	3314	c.3218C>G	c.(3217-3219)TCC>TGC	p.S1073C	GPR98_uc003kjt.2_Translation_Start_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1073	Calx-beta 8.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAGAGCATATCCATATTTGTT	0.383			NA											37	255					0	0	0.009718	0	0
RHOBTB3	22836	broad.mit.edu	37	5	95091260	95091260	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:95091260C>T	uc003klm.2	+	6	1380	c.843C>T	c.(841-843)TTC>TTT	p.F281F	RHOBTB3_uc003klk.1_Silent_p.F75F	NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	281	BTB 1.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		GCCATGTTTTCATGCTGCTTT	0.433			NA											39	139					0	0	0.009718	0	0
TCF7	6932	broad.mit.edu	37	5	133477970	133477970	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:133477970G>A	uc003kyt.2	+	6	926	c.730G>A	c.(730-732)GAG>AAG	p.E244K	TCF7_uc003kyu.1_Missense_Mutation_p.E129K|TCF7_uc003kyv.2_Missense_Mutation_p.E129K|TCF7_uc003kyw.2_Missense_Mutation_p.E129K|TCF7_uc003kyx.2_Missense_Mutation_p.E42K|TCF7_uc003kyy.2_Missense_Mutation_p.E129K|TCF7_uc003kyz.2_Missense_Mutation_p.E129K|TCF7_uc003kza.2_Missense_Mutation_p.E129K|TCF7_uc003kzb.2_Missense_Mutation_p.E58K|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	244					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGGAAGCAGGAGCTGCAGCC	0.607			NA											11	85					0	0	0.020292	0	0
KLHL3	26249	broad.mit.edu	37	5	137056262	137056262	+	Missense_Mutation	SNP	C	C	G	rs138386996		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:137056262C>G	uc010jek.2	-	2	470	c.26G>C	c.(25-27)AGC>ACC	p.S9T	MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Intron	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	9						cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		AGTCTGGGAGCTCAGCTTGAC	0.488			NA											125	412					0	0	0.01441	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236393	140236393	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:140236393C>T	uc003lhx.2	+	1	760	c.760C>T	c.(760-762)CAA>TAA	p.Q254*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Nonsense_Mutation_p.Q254*|PCDHA10_uc011dad.1_Nonsense_Mutation_p.Q254*	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	254	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTATGAAAATCAAGTGAACCA	0.403			NA											6	65					0	0	0.001984	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481829	140481829	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:140481829C>T	uc003lio.2	+	1	1596	c.1596C>T	c.(1594-1596)GGC>GGT	p.G532G	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	532	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGCGTGGGCGCCACAGACC	0.672			NA											8	41					0	0	0.006214	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801351	140801351	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:140801351G>A	uc003lkq.1	+	1	815	c.557G>A	c.(556-558)AGA>AAA	p.R186K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.R186K|PCDHGA11_uc003lkp.1_Missense_Mutation_p.R186K	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	186	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGGGGCAGAACGGATGGG	0.542			NA											5	44					0	0	0.001168	0	0
PANK3	79646	broad.mit.edu	37	5	167995708	167995708	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:167995708C>G	uc003lzz.1	-	2	624	c.324G>C	c.(322-324)CAG>CAC	p.Q108H		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	108					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		ATAGCACCGTCTGCAATGTTG	0.398			NA											6	93					0	0	0.00308	0	0
NUP153	9972	broad.mit.edu	37	6	17632972	17632972	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:17632972G>C	uc003ncd.1	-	17	2768	c.2568C>G	c.(2566-2568)GAC>GAG	p.D856E	NUP153_uc011dje.1_Missense_Mutation_p.D887E|NUP153_uc010jpl.1_Missense_Mutation_p.D814E	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	856	RanBP2-type 4.				carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ACAATTCACAGTCCCAGCTTC	0.478			NA											51	601					0	0	0.01441	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726495	25726495	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:25726495C>T	uc003nfc.2	-	1	296	c.261G>A	c.(259-261)GCG>GCA	p.A87A	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	87					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CATTGCGGATCGCTAGCTGCA	0.527			NA											36	194					0	0	0.006999	0	0
SCAND3	114821	broad.mit.edu	37	6	28542753	28542753	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:28542753C>T	uc003nlo.2	-	3	2347	c.1729G>A	c.(1729-1731)GAT>AAT	p.D577N		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	577					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCTTCAATATCACTACTGTCT	0.373			NA											8	73					0	0	0.004482	0	0
CCHCR1	54535	broad.mit.edu	37	6	31110851	31110851	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:31110851G>A	uc003nsr.3	-	17	2236	c.2113C>T	c.(2113-2115)CTT>TTT	p.L705F	CCHCR1_uc011dne.1_Missense_Mutation_p.L691F|CCHCR1_uc003nsq.3_Missense_Mutation_p.L758F|CCHCR1_uc003nsp.3_Missense_Mutation_p.L794F	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	705					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						AGGGAAGGAAGAACTGTCAAC	0.567			NA											121	320					0	0	0.01441	0	0
TCF19	6941	broad.mit.edu	37	6	31129531	31129531	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:31129531C>A	uc003nss.2	+	3	1070	c.546C>A	c.(544-546)CTC>CTA	p.L182L	TCF19_uc003nst.2_Silent_p.L182L	NM_001077511	NP_001070979	Q9Y242	TCF19_HUMAN	transcription factor 19	182					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TAGGCAGCCTCAGCAAGCTCC	0.657			NA											5	40					3.59834e-05	3.78318e-05	0.001168	1	0
TRERF1	55809	broad.mit.edu	37	6	42224500	42224500	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:42224500A>C	uc003osd.2	-	12	3109	c.2546T>G	c.(2545-2547)TTG>TGG	p.L849W	TRERF1_uc011duq.1_Missense_Mutation_p.L766W|TRERF1_uc003osb.2_Missense_Mutation_p.L605W|TRERF1_uc003osc.2_Missense_Mutation_p.L605W|TRERF1_uc003ose.2_Missense_Mutation_p.L869W	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	849	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CAGAGAGTGCAAAGCAAATTC	0.418			NA											18	213					0	0	0.014323	0	0
FAM83B	222584	broad.mit.edu	37	6	54806253	54806253	+	Silent	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:54806253T>C	uc003pck.2	+	5	2600	c.2484T>C	c.(2482-2484)CCT>CCC	p.P828P		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	828										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ATTCATCTCCTAGAAGAAAGC	0.393			NA											19	70					0	0	0.012319	0	0
COL19A1	1310	broad.mit.edu	37	6	70852699	70852699	+	Missense_Mutation	SNP	C	C	A	rs143251981	byFrequency	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:70852699C>A	uc003pfc.1	+	23	1730	c.1613C>A	c.(1612-1614)CCG>CAG	p.P538Q	COL19A1_uc010kam.1_Missense_Mutation_p.P434Q	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	538	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CCCAGAGGACCGCCAGGAGAT	0.358			NA											24	68					5.61819e-17	6.63378e-17	0.005443	1	0
BCLAF1	9774	broad.mit.edu	37	6	136582459	136582459	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:136582459C>T	uc003qgx.1	-	12	2954	c.2701G>A	c.(2701-2703)GAA>AAA	p.E901K	BCLAF1_uc011edb.1_Missense_Mutation_p.E180K|BCLAF1_uc003qgw.1_Missense_Mutation_p.E728K|BCLAF1_uc003qgy.1_Missense_Mutation_p.E850K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.E899K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	901					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTCTCTTCTTCATCTTCAACA	0.368	Colon(142;1534 1789 5427 7063 28491)		NA											14	369					0	0	0.00499	0	0
C6orf97	80129	broad.mit.edu	37	6	151859248	151859248	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:151859248G>A	uc003qol.2	+	3	344	c.255G>A	c.(253-255)GAG>GAA	p.E85E		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	85	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		CTGAAATGGAGAGCTACAAGG	0.383			NA											21	187					0	0	0.016522	0	0
SYNE1	23345	broad.mit.edu	37	6	152680536	152680536	+	Missense_Mutation	SNP	C	C	A	rs139823841	by1000genomes	TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:152680536C>A	uc010kiw.2	-	65	10959	c.10357G>T	c.(10357-10359)GGG>TGG	p.G3453W	SYNE1_uc003qot.3_Missense_Mutation_p.G3460W|SYNE1_uc003qou.3_Missense_Mutation_p.G3453W|SYNE1_uc010kja.1_Missense_Mutation_p.G158W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3453	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGCCAGCCCCTTTGACTTCG	0.468			NA								HNSCC(10;0.0054)			34	107					1.414e-09	1.56151e-09	0.017118	1	0
TCP1	6950	broad.mit.edu	37	6	160206484	160206484	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:160206484T>C	uc003qsr.2	-	5	657	c.422A>G	c.(421-423)GAT>GGT	p.D141G	TCP1_uc003qss.2_5'UTR|TCP1_uc010kjz.2_Missense_Mutation_p.D141G|TCP1_uc003qst.2_Intron	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	141					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TCCCAGTTCATCTGTGTTAAC	0.368			NA											46	123					0	0	0.01441	0	0
TCP10L2	401285	broad.mit.edu	37	6	167587449	167587449	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:167587449A>G	uc010kkp.2	+	3	484	c.353A>G	c.(352-354)CAC>CGC	p.H118R		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	118											0						CGAGAATCACACACTCTGGTA	0.572			NA											12	50					0	0	0.017118	0	0
THBS2	7058	broad.mit.edu	37	6	169629774	169629774	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:169629774C>T	uc003qwt.2	-	15	2400	c.2152G>A	c.(2152-2154)GAT>AAT	p.D718N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	718	TSP type-3 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGGCAGTTATCCTGCAATTGG	0.493	Esophageal Squamous(91;219 1934 18562 44706)		NA											8	72					0	0	0.004482	0	0
SDK1	221935	broad.mit.edu	37	7	4116733	4116733	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:4116733C>A	uc003smx.2	+	21	3253	c.3114C>A	c.(3112-3114)CTC>CTA	p.L1038L	SDK1_uc010kso.2_Silent_p.L314L	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1038	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCTCATCTCTCACCACCTACA	0.567			NA											12	107					3.27435e-08	3.53953e-08	0.020292	1	0
SDK1	221935	broad.mit.edu	37	7	4198173	4198173	+	Silent	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:4198173G>C	uc003smx.2	+	31	4858	c.4719G>C	c.(4717-4719)ACG>ACC	p.T1573T	SDK1_uc010kso.2_Silent_p.T849T|SDK1_uc003smy.2_Silent_p.T60T	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1573					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGGTGACCACGCTGCAGGATG	0.602			NA											20	94					0	0	0.008871	0	0
TWISTNB	221830	broad.mit.edu	37	7	19738310	19738310	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:19738310C>T	uc003sup.1	-	4	667	c.646G>A	c.(646-648)GAA>AAA	p.E216K		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	216						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						GTGCCATTTTCTGTAACTTCT	0.333			NA											8	101					0	0	0.006214	0	0
TWISTNB	221830	broad.mit.edu	37	7	19739839	19739839	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:19739839G>C	uc003sup.1	-	3	482	c.461C>G	c.(460-462)TCC>TGC	p.S154C		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	154						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						TTTAGGAATGGAGGCATTGAA	0.408			NA											39	245					0	0	0.011902	0	0
DNAH11	8701	broad.mit.edu	37	7	21630855	21630855	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:21630855C>T	uc003svc.2	+	14	2358	c.2327C>T	c.(2326-2328)ACG>ATG	p.T776M		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	776	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTCAAACAGACGCTCCTGGAA	0.448			NA							Kartagener_syndrome				12	80					0	0	0.003163	0	0
HIBADH	11112	broad.mit.edu	37	7	27565834	27565834	+	Nonstop_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:27565834C>A	uc003szf.2	-	8	1205	c.1010G>T	c.(1009-1011)TGA>TTA	p.*337L	HIBADH_uc003szg.2_Nonstop_Mutation_p.*288L|HIBADH_uc003szh.2_Nonstop_Mutation_p.*236L	NM_152740	NP_689953	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase precursor	337					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	AGGGCACACTCAGAAGGTCTC	0.488			NA											20	48					6.44725e-10	7.1714e-10	0.014323	1	0
PCLO	27445	broad.mit.edu	37	7	82595703	82595703	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:82595703G>A	uc003uhx.2	-	4	3690	c.3401C>T	c.(3400-3402)GCA>GTA	p.A1134V	PCLO_uc003uhv.2_Missense_Mutation_p.A1134V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1073					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CATAGGAGATGCTTTGGGTCC	0.423			NA											20	166					0	0	0.014323	0	0
LRRN3	54674	broad.mit.edu	37	7	110764566	110764566	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:110764566C>T	uc003vft.3	+	4	2784	c.1738C>T	c.(1738-1740)CTT>TTT	p.L580F	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.L580F|LRRN3_uc003vfs.3_Missense_Mutation_p.L580F	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	580	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGTATATAATCTTACTCATCT	0.348			NA											6	77					0	0	0.001168	0	0
GPR85	54329	broad.mit.edu	37	7	112724255	112724255	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:112724255G>T	uc010ljv.2	-	2	1039	c.522C>A	c.(520-522)TTC>TTA	p.F174L	GPR85_uc003vgp.1_Missense_Mutation_p.F174L|GPR85_uc003vgq.2_Missense_Mutation_p.F174L|GPR85_uc010ljw.1_Missense_Mutation_p.F174L	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	174	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						AGCGGTGTTGGAAGGTGCATT	0.478			NA											14	136					6.72482e-11	7.56235e-11	0.003163	1	0
FSCN3	29999	broad.mit.edu	37	7	127234028	127234028	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:127234028G>T	uc003vmd.1	+	1	340	c.121G>T	c.(121-123)GCG>TCG	p.A41S	FSCN3_uc003vmc.1_Intron|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_5'UTR|FSCN3_uc010llc.1_Missense_Mutation_p.A41S	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	41						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CACTGCAACTGCGAAGAGTTT	0.458			NA											6	18					0.00307968	0.00317269	0.00308	1	0
ZNF425	155054	broad.mit.edu	37	7	148801601	148801601	+	Silent	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:148801601C>T	uc003wfj.2	-	4	1435	c.1362G>A	c.(1360-1362)AGG>AGA	p.R454R		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	454	C2H2-type 9.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCATGGCGTTCCTCCAGAAGA	0.657			NA											4	32					0	0	0.009096	0	0
RHEB	6009	broad.mit.edu	37	7	151174480	151174480	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:151174480G>C	uc003wkh.1	-	4	627	c.214C>G	c.(214-216)CAG>GAG	p.Q72E		NM_005614	NP_005605	Q15382	RHEB_HUMAN	Ras homolog enriched in brain precursor	72					cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding			large_intestine(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		GAGTATGTCTGAGGAAAGATA	0.338	Pancreas(98;671 892 8111 15140 36556 39178 39939 44184)		NA											5	151					0	0	0.001168	0	0
MLL3	58508	broad.mit.edu	37	7	151917783	151917783	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:151917783C>G	uc003wla.2	-	23	3756	c.3537G>C	c.(3535-3537)TTG>TTC	p.L1179F	MLL3_uc003wkz.2_Missense_Mutation_p.L240F	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1179					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTGATTCAGTCAAACACACAC	0.348	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								6	60					0	0	0.006214	0	0
PCM1	5108	broad.mit.edu	37	8	17813044	17813044	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:17813044C>T	uc003wyi.3	+	10	1776	c.1354C>T	c.(1354-1356)CCG>TCG	p.P452S	PCM1_uc011kyh.1_Missense_Mutation_p.P452S|PCM1_uc003wyj.3_Missense_Mutation_p.P452S|PCM1_uc003wyh.2_Missense_Mutation_p.P491S|PCM1_uc010lta.1_Missense_Mutation_p.P491S	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	452					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		AGGCTTGGCACCGGTTGTCAA	0.438			NA	T	RET|JAK2	papillary thyroid|CML|MPD								9	75					0	0	0.008291	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19363303	19363303	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:19363303C>A	uc011kyn.1	-	4	1107	c.43G>T	c.(43-45)GTG>TTG	p.V15L	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.V15L|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.V14L|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	15	Helical; Signal-anchor for type II membrane protein; (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		AAAACCACCACCCGGGAAATC	0.617			NA											41	164					1.35964e-18	1.61786e-18	0.01441	1	0
ERLIN2	11160	broad.mit.edu	37	8	37607085	37607085	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:37607085G>C	uc003xke.3	+	7	548	c.433G>C	c.(433-435)GAT>CAT	p.D145H	LOC728024_uc010lvx.1_5'Flank	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	145	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			AGATCAGATTGATGAAAATCT	0.478			NA											16	96					0	0	0.007413	0	0
CHRNB3	1142	broad.mit.edu	37	8	42552716	42552716	+	Silent	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:42552716C>A	uc003xpi.1	+	1	155	c.27C>A	c.(25-27)CTC>CTA	p.L9L		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	9					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGCTGGTTCTCATCGTCCTTG	0.413			NA											16	157					3.08376e-08	3.34528e-08	0.01892	1	0
HGSNAT	138050	broad.mit.edu	37	8	43016642	43016642	+	Silent	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:43016642C>G	uc003xpx.3	+	5	603	c.555C>G	c.(553-555)CTC>CTG	p.L185L		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	213	Cytoplasmic (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TTCTGAGGCTCTTGTTGAGGT	0.438			NA											27	64					0	0	0.021022	0	0
TRPA1	8989	broad.mit.edu	37	8	72967797	72967797	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:72967797T>A	uc003xza.2	-	12	1578	c.1403A>T	c.(1402-1404)GAC>GTC	p.D468V		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	468	ANK 11.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ATCACTTATGTCTTGTAGGAG	0.388			NA											56	206					0	0	0.01441	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619868	77619868	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:77619868C>G	uc003yav.2	+	3	2987	c.2600C>G	c.(2599-2601)TCA>TGA	p.S867*	ZFHX4_uc003yat.1_Nonsense_Mutation_p.S867*|ZFHX4_uc003yau.1_Nonsense_Mutation_p.S893*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.S867*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	867						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GGAGAGCTGTCACCTTATATC	0.502			NA								HNSCC(33;0.089)			7	81					0	0	0.004482	0	0
TMEM67	91147	broad.mit.edu	37	8	94767165	94767165	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:94767165G>T	uc011lgk.1	+	1	94	c.23G>T	c.(22-24)GGG>GTG	p.G8V	TMEM67_uc010mau.2_Missense_Mutation_p.G8V|TMEM67_uc010mav.2_Missense_Mutation_p.G8V|TMEM67_uc010mat.1_Intron|TMEM67_uc010maw.2_Missense_Mutation_p.G8V|TMEM67_uc003yga.3_Intron	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	8					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GGTGGGGCTGGGGTGGCAATG	0.642			NA											16	74					2.49675e-24	3.06601e-24	0.007291	1	0
RIMS2	9699	broad.mit.edu	37	8	104922405	104922405	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:104922405C>A	uc003yls.2	+	3	1243	c.1002C>A	c.(1000-1002)AGC>AGA	p.S334R	RIMS2_uc003ylp.2_Missense_Mutation_p.S556R|RIMS2_uc003ylw.2_Missense_Mutation_p.S364R|RIMS2_uc003ylq.2_Missense_Mutation_p.S364R|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGGCATAGCAGTGAGGCAT	0.403			NA								HNSCC(12;0.0054)			65	231					7.427e-35	9.34462e-35	0.01441	1	0
KLHL38	340359	broad.mit.edu	37	8	124665152	124665152	+	Silent	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:124665152T>C	uc003yqs.1	-	1	39	c.15A>G	c.(13-15)TCA>TCG	p.S5S		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	5											0						GCCCATCTAGTGACTCCTCGT	0.522			NA											42	221					0	0	0.01441	0	0
FAM91A1	157769	broad.mit.edu	37	8	124797966	124797966	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:124797966C>T	uc003yqv.2	+	11	1008	c.947C>T	c.(946-948)TCC>TTC	p.S316F	FAM91A1_uc011lik.1_Missense_Mutation_p.S316F|FAM91A1_uc011lil.1_Missense_Mutation_p.S74F	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	316										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AATGTTCCATCCGTAAACAGA	0.294			NA											7	115					0	0	0.00308	0	0
MTSS1	9788	broad.mit.edu	37	8	125580618	125580618	+	Splice_Site	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:125580618A>G	uc003yrk.2	-	7	1152	c.618_splice	c.e7+1	p.I206_splice	NDUFB9_uc011lim.1_3'UTR|MTSS1_uc011lin.1_5'Flank|MTSS1_uc011lio.1_Intron|MTSS1_uc003yri.2_Splice_Site_p.I6_splice|MTSS1_uc003yrj.2_Splice_Site_p.I206_splice|MTSS1_uc003yrl.2_Splice_Site_p.I210_splice	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1						actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCATTAACTTACAATCACTGG	0.438	Esophageal Squamous(160;622 1893 3862 8546 12509)		NA											52	187					0	0	0.01441	0	0
PHF20L1	51105	broad.mit.edu	37	8	133848837	133848837	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:133848837G>A	uc003ytt.2	+	16	2287	c.1962G>A	c.(1960-1962)CTG>CTA	p.L654L	PHF20L1_uc011lja.1_Silent_p.L628L	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	654							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GTTTGCTTCTGAGTGGGGATG	0.343			NA											24	188					0	0	0.007291	0	0
PLEC	5339	broad.mit.edu	37	8	144994218	144994218	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:144994218G>A	uc003zaf.1	-	32	10352	c.10182C>T	c.(10180-10182)ATC>ATT	p.I3394I	PLEC_uc003zab.1_Silent_p.I3257I|PLEC_uc003zac.1_Silent_p.I3261I|PLEC_uc003zad.2_Silent_p.I3257I|PLEC_uc003zae.1_Silent_p.I3225I|PLEC_uc003zag.1_Silent_p.I3235I|PLEC_uc003zah.2_Silent_p.I3243I|PLEC_uc003zaj.2_Silent_p.I3284I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3394	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACTCAGAGCTGATGAGCTCCC	0.587			NA											11	36					0	0	0.016723	0	0
C8orf33	65265	broad.mit.edu	37	8	146278275	146278275	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr8:146278275G>A	uc003zfc.3	+	2	364	c.310G>A	c.(310-312)GAG>AAG	p.E104K	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	104											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		CCTAAGCGCTGAGGCCCAGGC	0.602			NA											4	11					0	0	0.009096	0	0
KIF27	55582	broad.mit.edu	37	9	86502017	86502017	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr9:86502017C>G	uc004ana.2	-	9	2322	c.2178G>C	c.(2176-2178)ATG>ATC	p.M726I	KIF27_uc010mpw.2_Missense_Mutation_p.M726I|KIF27_uc010mpx.2_Missense_Mutation_p.M726I	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	726	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TAAGTTCTCTCATTTTTTGTT	0.284			NA											6	42					0	0	0.001168	0	0
RNF20	56254	broad.mit.edu	37	9	104323505	104323505	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr9:104323505G>C	uc004bbn.2	+	18	2732	c.2642G>C	c.(2641-2643)CGA>CCA	p.R881P		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	881	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AATTTCAAACGAGCCCAGGTA	0.373			NA											122	300					0	0	0.01441	0	0
NTNG2	84628	broad.mit.edu	37	9	135073529	135073530	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr9:135073529_135073530CG>AA	uc004cbh.2	+	3	1166_1167	c.390_391CG>AA	c.(388-393)ACCGTG>ACAATG	p.V131M		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	131	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GGAACAAGACCGTGGAGCTGAC	0.639			NA											6	29					0	0	0.004672	0	0
LCN12	286256	broad.mit.edu	37	9	139847406	139847406	+	Silent	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr9:139847406G>A	uc004ckb.2	+	2	189	c.177G>A	c.(175-177)GCG>GCA	p.A59A	LCN12_uc004ckc.2_Silent_p.A59A	NM_178536	NP_848631	Q6JVE5	LCN12_HUMAN	lipocalcin 12 precursor	59					lipid metabolic process	extracellular region	binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		AGCACAGGGCGCTGCTGAACG	0.627			NA											7	53					0	0	0.006214	0	0
KAL1	3730	broad.mit.edu	37	X	8536381	8536381	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:8536381C>T	uc004csf.2	-	8	1249	c.1099G>A	c.(1099-1101)GAC>AAC	p.D367N		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	367	Fibronectin type-III 2.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						TAGTCACAGTCTGGCTGGAGT	0.443			NA											25	191					0	0	0.007291	0	0
TCEANC	170082	broad.mit.edu	37	X	13680667	13680667	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:13680667A>G	uc004cvk.2	+	2	270	c.40A>G	c.(40-42)ATT>GTT	p.I14V	TCEANC_uc010nee.1_Missense_Mutation_p.I14V|TCEANC_uc010nef.1_Missense_Mutation_p.I14V|TCEANC_uc010neg.1_Missense_Mutation_p.I44V|TCEANC_uc004cvl.2_RNA	NM_152634	NP_689847	Q8N8B7	TEANC_HUMAN	TFIIS central domain-containing protein 1	14	TFIIS N-terminal.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1						AGCTTCTCTTATTGAGCAACT	0.418			NA											32	244					0	0	0.00623	0	0
CDKL5	6792	broad.mit.edu	37	X	18606111	18606111	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:18606111G>T	uc004cym.2	+	9	845	c.592G>T	c.(592-594)GGC>TGC	p.G198C	CDKL5_uc004cyn.2_Missense_Mutation_p.G198C	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	198	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GTGGTCGGTGGGCTGTATTCT	0.408			NA											96	589					2.96273e-59	3.75851e-59	0.01441	1	0
MAP7D2	256714	broad.mit.edu	37	X	20043822	20043822	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:20043822C>T	uc004czr.1	-	8	1152	c.1133G>A	c.(1132-1134)GGA>GAA	p.G378E	MAP7D2_uc004czq.1_Missense_Mutation_p.G263E|MAP7D2_uc011mji.1_Missense_Mutation_p.G326E|MAP7D2_uc010nfo.1_Missense_Mutation_p.G419E|MAP7D2_uc011mjj.1_Missense_Mutation_p.G333E	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	378										ovary(2)|breast(1)	3						GGCTTTCCCTCCTGCGGCAGC	0.582			NA											34	255					0	0	0.012213	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414538	29414538	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:29414538G>C	uc004dby.2	+	4	1034	c.526G>C	c.(526-528)GAA>CAA	p.E176Q		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	176	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GCCAACCAGAGAACCTGAAAT	0.368			NA											32	135					0	0	0.00874	0	0
KDM5C	8242	broad.mit.edu	37	X	53245042	53245042	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:53245042G>C	uc004drz.2	-	7	1431	c.898C>G	c.(898-900)CAC>GAC	p.H300D	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.H233D|KDM5C_uc004dsa.2_Missense_Mutation_p.H299D	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	300					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TCTGGGCTGTGACTCAGCTCC	0.552			NA	N|F|S		clear cell renal carcinoma								34	139					0	0	0.021022	0	0
OPHN1	4983	broad.mit.edu	37	X	67518843	67518843	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:67518843C>A	uc004dww.3	-	3	544	c.250G>T	c.(250-252)GCT>TCT	p.A84S	OPHN1_uc011mpg.1_Missense_Mutation_p.A84S|OPHN1_uc004dwx.2_Missense_Mutation_p.A84S	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	84					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						GAAGACTTACCGATGTTAATT	0.413			NA											34	159					1.47197e-15	1.71172e-15	0.007835	1	0
P2RY4	5030	broad.mit.edu	37	X	69478529	69478529	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:69478529G>C	uc004dxz.1	-	1	1126	c.946C>G	c.(946-948)CAG>GAG	p.Q316E		NM_002565	NP_002556	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y4	316	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1						TGACGGAGCTGACGTCGATAT	0.607			NA											11	63					0	0	0.010729	0	0
DACH2	117154	broad.mit.edu	37	X	86067861	86067861	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:86067861G>A	uc004eew.2	+	8	1413	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	DACH2_uc004eex.2_Missense_Mutation_p.E402K|DACH2_uc010nmq.2_Missense_Mutation_p.E281K|DACH2_uc011mra.1_Missense_Mutation_p.E248K|DACH2_uc010nmr.2_Missense_Mutation_p.E196K|DACH2_uc004eey.2_Missense_Mutation_p.E98K|DACH2_uc004eez.2_Missense_Mutation_p.E98K	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						TTTTGCAGAAGAGGTACCAGT	0.408			NA											8	85					0	0	0.013537	0	0
CENPI	2491	broad.mit.edu	37	X	100382593	100382593	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:100382593C>T	uc004egx.2	+	10	1283	c.1013C>T	c.(1012-1014)TCA>TTA	p.S338L	CENPI_uc011mrg.1_Missense_Mutation_p.S338L|CENPI_uc004egy.2_Missense_Mutation_p.S338L	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	338					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						AGAAGTGGATCATTTCCACTA	0.378			NA											31	150					0	0	0.010818	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450161	105450161	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:105450161G>C	uc004emf.1	+	4	1385	c.736G>C	c.(736-738)GAT>CAT	p.D246H	MUM1L1_uc004emg.1_Missense_Mutation_p.D246H	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	246										ovary(2)|pancreas(1)|skin(1)	4						TTTGTCATCAGATATGCTCAT	0.433			NA											12	104					0	0	0.013537	0	0
RIPPLY1	92129	broad.mit.edu	37	X	106144762	106144762	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:106144762C>G	uc004emr.1	-	3	282	c.238G>C	c.(238-240)GGT>CGT	p.G80R	MORC4_uc004emp.3_Intron|CLDN2_uc004emq.1_Intron|RIPPLY1_uc004ems.1_Intron	NM_138382	NP_612391	Q0D2K3	RIPP1_HUMAN	ripply1 homolog	80					negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus					0						GTTGCCCCACCAGCAGCCTGT	0.478			NA											32	464					0	0	0.013114	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995615	140995615	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:140995615C>G	uc004fbt.2	+	4	2711	c.2425C>G	c.(2425-2427)CCT>GCT	p.P809A	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	809							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCCAGTCTCCTCTCCAGAG	0.557			NA								HNSCC(15;0.026)			91	234					0	0	0.01441	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905709	144905709	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:144905709T>A	uc004fcd.2	+	5	2756	c.1766T>A	c.(1765-1767)GTC>GAC	p.V589D	SLITRK2_uc010nsp.2_Missense_Mutation_p.V589D|SLITRK2_uc010nso.2_Missense_Mutation_p.V589D|SLITRK2_uc011mwq.1_Missense_Mutation_p.V589D|SLITRK2_uc011mwr.1_Missense_Mutation_p.V589D|SLITRK2_uc011mws.1_Missense_Mutation_p.V589D|SLITRK2_uc004fcg.2_Missense_Mutation_p.V589D|SLITRK2_uc011mwt.1_Missense_Mutation_p.V589D	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	589	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GATGGAACCGTCTTGTCAATG	0.468			NA											8	62					0	0	0.004482	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013937	149013937	+	Silent	SNP	T	T	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:149013937T>C	uc004fdw.1	+	3	1106	c.891T>C	c.(889-891)AAT>AAC	p.N297N		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	297	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGGTCAATGCAAGAGTTC	0.567			NA											7	303					0	0	0.008291	0	0
PNCK	139728	broad.mit.edu	37	X	152937028	152937028	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:152937028C>T	uc011myu.1	-	6	949	c.763G>A	c.(763-765)GCC>ACC	p.A255T	PNCK_uc011myt.1_Missense_Mutation_p.A189T|PNCK_uc004fia.2_Missense_Mutation_p.A184T|PNCK_uc004fhz.3_Missense_Mutation_p.A70T|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_Missense_Mutation_p.A199T|PNCK_uc011myw.1_Missense_Mutation_p.A199T	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	172	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCCCACAGGCGGTGCCTAGC	0.602			NA											11	61					0	0	0.003163	0	0
KCNQ4	9132	broad.mit.edu	37	1	41289922	41289923	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:41289922_41289923insG	uc001cgh.1	+	9	1366_1367	c.1284_1285insG	c.(1282-1287)CCTGGGfs	p.P428fs	KCNQ4_uc001cgi.1_Intron	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	428_429	Cytoplasmic.				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CCTTCTGCCCTGGGGAAAGGTA	0.678			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
GON4L	54856	broad.mit.edu	37	1	155734980	155734981	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:155734980_155734981insG	uc001flz.2	-	21	4380_4381	c.4283_4284insC	c.(4282-4284)CCAfs	p.P1428fs	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Frame_Shift_Ins_p.P1428fs|GON4L_uc009wrh.1_Frame_Shift_Ins_p.P1428fs|GON4L_uc001fma.1_Frame_Shift_Ins_p.P1428fs|GON4L_uc001fmb.3_Frame_Shift_Ins_p.P624fs|GON4L_uc001fmc.2_Frame_Shift_Ins_p.P1428fs|GON4L_uc001fmd.3_Frame_Shift_Ins_p.P1428fs|GON4L_uc009wri.2_Frame_Shift_Ins_p.P1014fs	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1428					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTGGCTTCCCTGGGGGGCTACT	0.515			NA											7	251	---	---	---	---	NA	NA	NA	NA	NA
C1orf49	84066	broad.mit.edu	37	1	178489899	178489899	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr1:178489899delG	uc001glt.1	+	7	545	c.433delG	c.(433-435)GGAfs	p.G145fs	C1orf49_uc001glu.1_Frame_Shift_Del_p.G145fs|C1orf49_uc001glv.1_RNA|C1orf49_uc001glw.1_Frame_Shift_Del_p.G153fs	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	145						microtubule cytoskeleton					0						GAAAATGGATGGAGCCAGTGG	0.532			NA											45	321	---	---	---	---	NA	NA	NA	NA	NA
C10orf47	254427	broad.mit.edu	37	10	11911725	11911726	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:11911725_11911726insA	uc001ikx.2	+	4	782_783	c.628_629insA	c.(628-630)GCCfs	p.A210fs	uc001iky.1_Intron	NM_153256	NP_694988	Q86WR7	CJ047_HUMAN	hypothetical protein LOC254427	210	Pro-rich.									central_nervous_system(1)	1						GGGGAACGAAGCCCTCTCGCCC	0.738			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
GDF2	2658	broad.mit.edu	37	10	48414131	48414131	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr10:48414131delG	uc001jfa.1	-	2	900	c.737delC	c.(736-738)CCAfs	p.P246fs		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	246					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TCTGGAACCTGGGGGGACACT	0.567			NA											7	26	---	---	---	---	NA	NA	NA	NA	NA
SLCO1C1	53919	broad.mit.edu	37	12	20874949	20874949	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:20874949delG	uc001rej.3	+	9	1342	c.987delG	c.(985-987)CAGfs	p.Q329fs	SLCO1C1_uc010sii.1_Frame_Shift_Del_p.Q329fs|SLCO1C1_uc010sij.1_Frame_Shift_Del_p.Q280fs|SLCO1C1_uc009zip.2_Frame_Shift_Del_p.Q163fs|SLCO1C1_uc001rei.2_Frame_Shift_Del_p.Q329fs|SLCO1C1_uc010sik.1_Frame_Shift_Del_p.Q211fs	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	329	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AAACACCCCAGGGAGAAAATG	0.299			NA											34	46	---	---	---	---	NA	NA	NA	NA	NA
MYL2	4633	broad.mit.edu	37	12	111348950	111348951	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:111348950_111348951insG	uc001try.3	-	7	502_503	c.431_432insC	c.(430-432)CCTfs	p.P144fs	MYL2_uc001trx.3_Frame_Shift_Ins_p.P125fs	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	144	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						CAGTCACGTCAGGGGGGAAGGC	0.624	GBM(14;268 426 18829 21617 25540)		NA											7	643	---	---	---	---	NA	NA	NA	NA	NA
KIAA0564	23078	broad.mit.edu	37	13	42407556	42407560	+	Frame_Shift_Del	DEL	GCAGG	GCAGG	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	GCAGG	GCAGG	-	-	GCAGG	GCAGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr13:42407556_42407560delGCAGG	uc001uyj.2	-	13	1603_1607	c.1533_1537delCCTGC	c.(1531-1539)GTCCTGCTGfs	p.V511fs	KIAA0564_uc001uyk.2_Frame_Shift_Del_p.V511fs	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	511_513						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		ATGCCATCCAGCAGGACCAGCTTGC	0.546			NA											10	259	---	---	---	---	NA	NA	NA	NA	NA
C14orf180	400258	broad.mit.edu	37	14	105054102	105054103	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr14:105054102_105054103insC	uc001yow.1	+	3	429_430	c.128_129insC	c.(127-129)TGCfs	p.C43fs	C14orf180_uc010tyh.1_Frame_Shift_Ins_p.C43fs|C14orf180_uc010awy.1_Frame_Shift_Ins_p.C43fs	NM_001008404	NP_001008404	Q8N912	CN180_HUMAN	hypothetical protein LOC400258	43						integral to membrane					0		Melanoma(154;0.226)	all cancers(16;0.00405)|OV - Ovarian serous cystadenocarcinoma(23;0.0319)|Epithelial(46;0.0784)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.127)		AACAGGAAGTGCCCCCCCTCCA	0.703			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579536	7579545	+	Frame_Shift_Del	DEL	CAATATCGTC	CAATATCGTC	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	CAATATCGTC	CAATATCGTC	-	-	CAATATCGTC	CAATATCGTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:7579536_7579545delCAATATCGTC	uc002gim.2	-	4	336_345	c.142_151delGACGATATTG	c.(142-153)GACGATATTGAAfs	p.D48fs	TP53_uc002gig.1_Frame_Shift_Del_p.D48fs|TP53_uc002gih.2_Frame_Shift_Del_p.D48fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.D48fs|TP53_uc010cni.1_Frame_Shift_Del_p.D48fs|TP53_uc002gij.2_Frame_Shift_Del_p.D48fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.D9fs|TP53_uc010cnk.1_Frame_Shift_Del_p.D63fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	48_51	TADII.|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E51*(6)|p.D49H(4)|p.D49Y(2)|p.E51fs*59(1)|p.I50fs*4(1)|p.D48fs*55(1)|p.I50fs*1(1)|p.E51fs*72(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D48D(1)|p.S46_D49delSPDD(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACCATTGTTCAATATCGTCCGGGGACAGC	0.543	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			91	1353	---	---	---	---	NA	NA	NA	NA	NA
STXBP4	252983	broad.mit.edu	37	17	53155556	53155559	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	GTAA	GTAA	-	-	GTAA	GTAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr17:53155556_53155559delGTAA	uc002iuf.1	+	14	1512	c.1305_splice	c.e14+1	p.E435_splice	STXBP4_uc010dcd.1_Splice_Site_p.E413_splice	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4							cytoplasm	calcium ion binding			ovary(1)	1						TTTTGTAGAGGTAAGTTTTTCTGT	0.328			NA											9	53	---	---	---	---	NA	NA	NA	NA	NA
CHERP	10523	broad.mit.edu	37	19	16646370	16646371	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr19:16646370_16646371insG	uc002nei.1	-	3	350_351	c.276_277insC	c.(274-279)CCCGCCfs	p.P92fs	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_Frame_Shift_Ins_p.P60fs	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	92_93					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						ATGGGCGCGGCGGGGGCCAGCG	0.713			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
SLC15A2	6565	broad.mit.edu	37	3	121648154	121648154	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:121648154delG	uc003eep.2	+	17	1665	c.1512delG	c.(1510-1512)AAGfs	p.K504fs	SLC15A2_uc011bjn.1_Frame_Shift_Del_p.K473fs	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	504					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TGTAGGTAAAGGATACAGAAA	0.388			NA											43	604	---	---	---	---	NA	NA	NA	NA	NA
PHC3	80012	broad.mit.edu	37	3	169896635	169896637	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	TGG	TGG	-	-	TGG	TGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:169896635_169896637delTGG	uc010hws.1	-	2	132_134	c.68_70delCCA	c.(67-72)ACCATC>ATC	p.T23del	PHC3_uc003fgl.2_In_Frame_Del_p.T35del|PHC3_uc011bpq.1_In_Frame_Del_p.T35del|PHC3_uc011bpr.1_In_Frame_Del_p.T35del|PHC3_uc003fgm.2_In_Frame_Del_p.T35del|PHC3_uc003fgo.1_In_Frame_Del_p.T23del|PHC3_uc003fgp.3_In_Frame_Del_p.T35del|PHC3_uc003fgq.3_In_Frame_Del_p.T35del|PHC3_uc003fgr.1_RNA	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	23	Poly-Thr.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAAgtggtgatggtggtggtggt	0.424			NA											8	1367	---	---	---	---	NA	NA	NA	NA	NA
FNDC3B	64778	broad.mit.edu	37	3	172096209	172096210	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:172096209_172096210insC	uc003fhy.2	+	24	3330_3331	c.3158_3159insC	c.(3157-3159)GTCfs	p.V1053fs	FNDC3B_uc003fhz.3_Frame_Shift_Ins_p.V1053fs	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1053						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACCAAAAGTGTCCCCCCCACCA	0.47			NA											7	222	---	---	---	---	NA	NA	NA	NA	NA
TNFSF10	8743	broad.mit.edu	37	3	172241148	172241149	+	Frame_Shift_Ins	INS	-	-	C	rs138912628		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr3:172241148_172241149insC	uc003fid.2	-	1	121_122	c.26_27insG	c.(25-27)GGAfs	p.G9fs	TNFSF10_uc003fie.2_Frame_Shift_Ins_p.G9fs|TNFSF10_uc010hwu.1_RNA	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	9	Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCAGGCTGGGTCCCCCCTGGAC	0.535			NA											7	797	---	---	---	---	NA	NA	NA	NA	NA
SEMA6A	57556	broad.mit.edu	37	5	115782764	115782765	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:115782764_115782765insG	uc010jck.2	-	19	3346_3347	c.2637_2638insC	c.(2635-2640)CCCAAAfs	p.P879fs	SEMA6A_uc003krx.3_Frame_Shift_Ins_p.P896fs|SEMA6A_uc011cwe.1_Frame_Shift_Ins_p.P258fs|SEMA6A_uc003krv.3_Frame_Shift_Ins_p.P306fs|SEMA6A_uc003krw.3_Frame_Shift_Ins_p.P356fs|SEMA6A_uc010jcj.2_Frame_Shift_Ins_p.P423fs	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	879_880	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGTGGAACTTTGGGGGGCAGGC	0.604			NA											9	311	---	---	---	---	NA	NA	NA	NA	NA
IK	3550	broad.mit.edu	37	5	140032593	140032594	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr5:140032593_140032594delGA	uc003lgq.2	+	5	378_379	c.268_269delGA	c.(268-270)GAGfs	p.E90fs	IK_uc011czk.1_Frame_Shift_Del_p.E90fs	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	90					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAGAAATTGAGAGAGAGAGA	0.46			NA											7	219	---	---	---	---	NA	NA	NA	NA	NA
BTN2A3	54718	broad.mit.edu	37	6	26426748	26426748	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr6:26426748delC	uc011dkl.1	+	3	733	c.703delC	c.(703-705)CCAfs	p.P235fs	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						CATTTTTATTCCAGGTTAGTT	0.527			NA											78	365	---	---	---	---	NA	NA	NA	NA	NA
TRRAP	8295	broad.mit.edu	37	7	98548545	98548546	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:98548545_98548546insG	uc003upp.2	+	38	5569_5570	c.5360_5361insG	c.(5359-5361)AAGfs	p.K1787fs	TRRAP_uc011kis.1_Frame_Shift_Ins_p.K1769fs|TRRAP_uc003upr.2_Frame_Shift_Ins_p.K1486fs	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1787					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTTTGAGAAGGGGGAAGGAG	0.411			NA											7	821	---	---	---	---	NA	NA	NA	NA	NA
EPHB6	2051	broad.mit.edu	37	7	142562397	142562398	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr7:142562397_142562398insC	uc011kst.1	+	7	1626_1627	c.839_840insC	c.(838-840)AGCfs	p.S280fs	EPHB6_uc011ksu.1_Frame_Shift_Ins_p.S280fs|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	280	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GCAGGAGGCAGCCCCCCCAGGC	0.688			NA											7	60	---	---	---	---	NA	NA	NA	NA	NA
FRMPD4	9758	broad.mit.edu	37	X	12734936	12734937	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:12734936_12734937insC	uc004cuz.1	+	15	2864_2865	c.2358_2359insC	c.(2356-2361)CTGCCCfs	p.L786fs	FRMPD4_uc011mij.1_Frame_Shift_Ins_p.L778fs	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	786_787					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TCACATCCCTGCCCCCTCCAGA	0.564			NA											7	834	---	---	---	---	NA	NA	NA	NA	NA
DLG3	1741	broad.mit.edu	37	X	69665334	69665335	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:69665334_69665335insC	uc004dyi.1	+	1	611_612	c.283_284insC	c.(283-285)ACCfs	p.T95fs		NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	95					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					GGGCAAGAGCACCCCCAAACTC	0.698			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
XPNPEP2	7512	broad.mit.edu	37	X	128890517	128890518	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chrX:128890517_128890518insG	uc004eut.1	+	14	1597_1598	c.1353_1354insG	c.(1351-1356)TCTGGGfs	p.S451fs		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	451_452					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						TGCTGGACTCTGGGGGGCAGTA	0.545			NA											8	165	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-64-1677-01A-01W-0928-08	TCGA-64-1677-10A-01W-0928-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	559017d8-4b22-4313-abdd-d3526c889d7f	1da1a9f9-7411-4230-b1ff-3e46a7b88efc	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	36	NA	NA	NA	NA	1	1	0.004482	1	1
