Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC440563	440563	broad.mit.edu	37	1	13183742	13183742	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:13183742G>A	uc010obg.1	-	1	226	c.131C>T	c.(130-132)GCG>GTG	p.A44V		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	44						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						AGAGCAGCCCGCAATTTTGCC	0.478			NA											9	55					0	0	0.069234	0	0
PI4KB	5298	broad.mit.edu	37	1	151271344	151271344	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:151271344T>C	uc001ext.2	-	9	2370	c.1955A>G	c.(1954-1956)AAT>AGT	p.N652S	PI4KB_uc001exr.2_Missense_Mutation_p.N664S|PI4KB_uc001exs.2_Missense_Mutation_p.N637S|PI4KB_uc001exu.2_Missense_Mutation_p.N637S|PI4KB_uc010pcw.1_Missense_Mutation_p.N320S	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	652	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTGCACAAAATTGCGCTGTGC	0.507	Colon(154;765 1838 9854 28443 37492)		NA											18	201					0	0	0.0333	0	0
USH2A	7399	broad.mit.edu	37	1	216419957	216419957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:216419957G>A	uc001hku.1	-	13	3166	c.2779C>T	c.(2779-2781)CAA>TAA	p.Q927*	USH2A_uc001hkv.2_Nonsense_Mutation_p.Q927*	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	927	Laminin EGF-like 8.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTCTTCCTTGACGATTAGGC	0.433			NA								HNSCC(13;0.011)			6	117					0	0	0.02938	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24896491	24896491	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:24896491G>A	uc001isb.2	-	11	3108	c.2621C>T	c.(2620-2622)TCA>TTA	p.S874L	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.S874L|ARHGAP21_uc010qdc.1_Missense_Mutation_p.S709L	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	873					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTCTGTCTTTGAGTTGGGCTG	0.358			NA											4	114					0	0	0.014758	0	0
CREM	1390	broad.mit.edu	37	10	35468111	35468111	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:35468111G>C	uc001iyb.2	+	5	478	c.316G>C	c.(316-318)GAA>CAA	p.E106Q	CREM_uc001ixx.2_Missense_Mutation_p.E90Q|CREM_uc001ixy.2_Intron|CREM_uc001ixz.2_Intron|CREM_uc001iya.2_Missense_Mutation_p.E106Q|CREM_uc001iyc.2_Missense_Mutation_p.E90Q|CREM_uc001iyd.2_Missense_Mutation_p.E106Q|CREM_uc001iye.2_Missense_Mutation_p.E106Q|CREM_uc001iyf.2_Missense_Mutation_p.E76Q|CREM_uc001iyg.2_Missense_Mutation_p.E76Q|CREM_uc001iyh.2_Missense_Mutation_p.E51Q|CREM_uc001iyi.2_Missense_Mutation_p.E51Q|CREM_uc001iyj.2_5'UTR|CREM_uc001iyk.2_5'UTR	NM_181571	NP_853549	Q03060	CREM_HUMAN	cAMP responsive element modulator isoform a	155	KID.				cell differentiation|multicellular organismal development|signal transduction|spermatogenesis	nucleus	cAMP response element binding protein binding|protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCCAAGATTGAAGAAGAGAG	0.393			NA											3	76					0	0	0.004672	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	A	G	rs2257765		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453			NA											3	65					0	0	0.004672	0	0
RTKN2	219790	broad.mit.edu	37	10	64000899	64000899	+	Splice_Site	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:64000899A>G	uc001jlw.2	-	4	467	c.370_splice	c.e4+1	p.R124_splice	RTKN2_uc001jlx.2_Splice_Site_p.R124_splice	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2						signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					AATCATACATACGTTCTTTAT	0.289			NA											3	35					0	0	0.004672	0	0
DEAF1	10522	broad.mit.edu	37	11	679720	679720	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:679720G>A	uc001lqq.1	-	8	1787	c.1094C>T	c.(1093-1095)CCG>CTG	p.P365L	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	365					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GCCCTGGGCCGGACTCTCTGA	0.637			NA											6	41					0	0	0.02938	0	0
NUP98	4928	broad.mit.edu	37	11	3704561	3704561	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:3704561G>A	uc001lyh.2	-	30	5078	c.4787C>T	c.(4786-4788)GCC>GTC	p.A1596V	NUP98_uc001lyi.2_Missense_Mutation_p.A1522V|NUP98_uc001lyg.2_Missense_Mutation_p.A561V	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1613					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GATCCATTTGGCAGGTACACG	0.537			NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								22	71					0	0	0.083992	0	0
OR1S1	219959	broad.mit.edu	37	11	57982677	57982677	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:57982677G>A	uc010rkc.1	+	1	461	c.461G>A	c.(460-462)GGC>GAC	p.G154D		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				CCCAGGTTCGGCATTTTGCTC	0.468			NA											4	235					0	0	0.009096	0	0
FERMT3	83706	broad.mit.edu	37	11	63990575	63990575	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:63990575C>T	uc001nyl.2	+	14	1887	c.1738C>T	c.(1738-1740)CGC>TGC	p.R580C	FERMT3_uc001nym.2_Missense_Mutation_p.R576C	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	580					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						CCGACTGATCCGCATCGACTT	0.627			NA											6	61					0	0	0.021553	0	0
ABCC9	10060	broad.mit.edu	37	12	22068751	22068751	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:22068751G>A	uc001rfi.1	-	5	687	c.667C>T	c.(667-669)CTG>TTG	p.L223L	ABCC9_uc001rfh.2_Silent_p.L223L|ABCC9_uc001rfj.1_Silent_p.L223L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	223	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCTTTTGACAGCAAATTCACA	0.393			NA											3	79					0	0	0.004672	0	0
LRRK2	120892	broad.mit.edu	37	12	40761481	40761481	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:40761481C>G	uc001rmg.3	+	51	7619	c.7498C>G	c.(7498-7500)CTT>GTT	p.L2500V	LRRK2_uc009zjw.2_Missense_Mutation_p.L1338V|LRRK2_uc001rmi.2_3'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2500					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGACATCAATCTTCCACATGA	0.303			NA											3	72					0	0	0.004672	0	0
PRIM1	5557	broad.mit.edu	37	12	57128024	57128024	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:57128024T>A	uc001smd.2	-	12	1214	c.1150A>T	c.(1150-1152)AAG>TAG	p.K384*		NM_000946	NP_000937	P49642	PRI1_HUMAN	DNA primase polypeptide 1	384					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding				0						CTGGTCTTCTTATAATCTAAA	0.299			NA											6	25					0	0	0.02938	0	0
C14orf73	91828	broad.mit.edu	37	14	103574737	103574737	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr14:103574737C>G	uc001ymk.2	+	10	1935	c.1859C>G	c.(1858-1860)TCC>TGC	p.S620C		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	620											0		Melanoma(154;0.155)	Epithelial(46;0.221)			TCGCAGGGTTCCGAGGCCACA	0.637			NA											10	117					0	0	0.058154	0	0
FAM81A	145773	broad.mit.edu	37	15	59801128	59801128	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:59801128C>G	uc002agc.2	+	6	797	c.610C>G	c.(610-612)CAC>GAC	p.H204D		NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	204										ovary(1)	1						GAAGATGTCTCACAGAGACAG	0.338			NA											3	53					0	0	0.004672	0	0
TRIP4	9325	broad.mit.edu	37	15	64717779	64717779	+	Silent	SNP	G	G	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:64717779G>T	uc002anm.2	+	11	1567	c.1524G>T	c.(1522-1524)CTG>CTT	p.L508L		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	508					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTGTCTTCTGGGCTGTGTGG	0.323			NA											35	106					9.73076e-26	1.0866e-25	0.092188	1	0
FANCI	55215	broad.mit.edu	37	15	89824490	89824490	+	Silent	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:89824490C>T	uc010bnp.1	+	15	1561	c.1471C>T	c.(1471-1473)CTG>TTG	p.L491L	FANCI_uc002bnm.1_Silent_p.L491L|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Silent_p.L312L|FANCI_uc002bnq.1_5'UTR	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	491					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTTGTCCTTTCTGCCCCTTCA	0.413			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				4	160					0	0	0.009096	0	0
MLST8	64223	broad.mit.edu	37	16	2258828	2258828	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr16:2258828C>T	uc002coz.2	+	9	1050	c.931C>T	c.(931-933)CAC>TAC	p.H311Y	MLST8_uc002cpa.2_Missense_Mutation_p.H127Y|MLST8_uc002cpb.2_Missense_Mutation_p.H310Y|MLST8_uc010uvx.1_Missense_Mutation_p.H245Y|MLST8_uc002cpc.2_Missense_Mutation_p.H311Y|MLST8_uc002cpd.2_Missense_Mutation_p.H245Y|MLST8_uc002cpe.2_Missense_Mutation_p.H311Y|MLST8_uc002cpg.2_Missense_Mutation_p.H330Y|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Missense_Mutation_p.H311Y	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	311					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						GTATGGCGGCCACCAGAAGGC	0.622			NA											16	197					0	0	0.038395	0	0
ABCC12	94160	broad.mit.edu	37	16	48145805	48145805	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr16:48145805T>A	uc002efc.1	-	14	2352	c.2006A>T	c.(2005-2007)GAT>GTT	p.D669V	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	669	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AATAACTTCATCACAAGACTC	0.398			NA											9	19					0	0	0.069234	0	0
SERPINF1	5176	broad.mit.edu	37	17	1675167	1675167	+	Silent	SNP	G	G	A	rs138341386	byFrequency	TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:1675167G>A	uc002ftl.2	+	5	598	c.441G>A	c.(439-441)AAG>AAA	p.K147K	SERPINF1_uc010cjw.2_5'UTR	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	147					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						TCTTCTCAGAGCTGCGCATAA	0.562			NA											12	12					0	0	0.024245	0	0
ATP1B2	482	broad.mit.edu	37	17	7557469	7557469	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:7557469C>T	uc002gif.1	+	4	1029	c.446C>T	c.(445-447)GCC>GTC	p.A149V		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	149	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		CCCAAACGTGCCTGCCAATTC	0.542			NA											43	174					0	0	0.042209	0	0
SLFN12	55106	broad.mit.edu	37	17	33749738	33749738	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:33749738G>C	uc002hji.3	-	2	687	c.310C>G	c.(310-312)CTG>GTG	p.L104V	SLFN12_uc002hjj.3_Missense_Mutation_p.L104V|SLFN12_uc010cts.2_Missense_Mutation_p.L104V	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	104							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACAAAAATCAGAAAGTAGTTA	0.358			NA											6	66					0	0	0.021553	0	0
ARL17A	51326	broad.mit.edu	37	17	44594493	44594493	+	Silent	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:44594493G>C	uc002iko.3	-	4	505	c.366C>G	c.(364-366)CTC>CTG	p.L122L	LRRC37A2_uc002ikn.1_Intron	NM_016632	NP_057716	Q8IVW1	ARL17_HUMAN	hypothetical protein LOC51326 isoform b	Error:Variant_position_missing_in_Q8IVW1_after_alignment					protein transport|vesicle-mediated transport	Golgi apparatus	GTP binding				0						ATCTGTCCAAGAGATGGGATG	0.343			NA											7	80					0	0	0.02938	0	0
SPOP	8405	broad.mit.edu	37	17	47688764	47688764	+	Missense_Mutation	SNP	A	A	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:47688764A>C	uc010dbk.2	-	7	1168	c.536T>G	c.(535-537)GTA>GGA	p.V179G	SPOP_uc002ipb.2_Missense_Mutation_p.V179G|SPOP_uc002ipc.2_Missense_Mutation_p.V179G|SPOP_uc002ipd.2_Missense_Mutation_p.V179G|SPOP_uc002ipe.2_Missense_Mutation_p.V179G|SPOP_uc002ipf.2_Missense_Mutation_p.V179G|SPOP_uc002ipg.2_Missense_Mutation_p.V179G	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	179	Required for nuclear localization.|BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						AGGAACCTTTACCATGTTCAT	0.493			NA								Prostate(2;0.17)			6	179					0	0	0.038147	0	0
EME1	146956	broad.mit.edu	37	17	48452594	48452594	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:48452594T>C	uc002iqs.1	+	2	98	c.25T>C	c.(25-27)TCA>CCA	p.S9P	MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_Missense_Mutation_p.S9P	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1	9					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GTCATCACCCTCACTGGATTC	0.428			NA						Direct_reversal_of_damage|Homologous_recombination					6	98					0	0	0.021553	0	0
LPIN2	9663	broad.mit.edu	37	18	2954540	2954540	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr18:2954540C>G	uc002klo.2	-	3	489	c.250G>C	c.(250-252)GGA>CGA	p.G84R		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	84	N-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		AAAGCTTCTCCGTTATCACCC	0.433			NA											7	75					0	0	0.047766	0	0
PTBP1	5725	broad.mit.edu	37	19	803570	803570	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:803570G>A	uc002lpr.2	+	3	155	c.49G>A	c.(49-51)GAC>AAC	p.D17N	PTBP1_uc002lpp.2_Missense_Mutation_p.D17N|PTBP1_uc002lpq.2_Missense_Mutation_p.D17N|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_5'UTR	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	17					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGGATCTGACGAGCTTTT	0.627			NA											6	70					0	0	0.047766	0	0
MUC16	94025	broad.mit.edu	37	19	9066642	9066642	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:9066642G>A	uc002mkp.2	-	3	21008	c.20804C>T	c.(20803-20805)TCC>TTC	p.S6935F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6937	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCTCAGAGGAAACAGACAT	0.458			NA											70	219					0	0	0.048971	0	0
ZNF780A	284323	broad.mit.edu	37	19	40581559	40581559	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:40581559G>A	uc002omy.2	-	6	1015	c.790C>T	c.(790-792)CTT>TTT	p.L264F	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.L264F|ZNF780A_uc010xvh.1_Missense_Mutation_p.L265F	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	264	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTTGAACAAGGTTTGAGCTA	0.398			NA											45	154					0	0	0.048971	0	0
NTF4	4909	broad.mit.edu	37	19	49564708	49564708	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:49564708C>T	uc002pmf.3	-	2	688	c.547G>A	c.(547-549)GAT>AAT	p.D183N	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	183					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		CCCTGGGCATCAGCGGTCAAT	0.667			NA											6	34					0	0	0.021553	0	0
ZNF331	55422	broad.mit.edu	37	19	54074859	54074859	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:54074859G>A	uc002qbx.1	+	6	1445	c.11G>A	c.(10-12)GGT>GAT	p.G4D	ZNF331_uc002qby.1_Missense_Mutation_p.G4D|ZNF331_uc002qbz.1_Missense_Mutation_p.G4D|ZNF331_uc002qca.1_Missense_Mutation_p.G4D|ZNF331_uc010eqr.1_Missense_Mutation_p.G4D|ZNF331_uc002qcb.1_Missense_Mutation_p.G4D|ZNF331_uc002qcc.1_Missense_Mutation_p.G4D|ZNF331_uc002qcd.1_Missense_Mutation_p.G4D	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CTGTTTCAGGGTTTGGTGACG	0.542			NA	T	?	follicular thyroid adenoma								41	503					0	0	0.048971	0	0
LILRB2	10288	broad.mit.edu	37	19	54780707	54780707	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:54780707G>A	uc002qfb.2	-	10	1703	c.1437C>T	c.(1435-1437)CTC>CTT	p.L479L	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.L479L|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.L478L|LILRB2_uc010yet.1_Silent_p.L363L	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	479	Helical; (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggagga	0.483			NA											4	111					0	0	0.009096	0	0
COL4A4	1286	broad.mit.edu	37	2	227886814	227886814	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr2:227886814C>T	uc010zlt.1	-	43	4820	c.4166G>A	c.(4165-4167)GGA>GAA	p.G1389E		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1389	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCTTCTGGTCCTCTCATGCC	0.547			NA											7	200					0	0	0.02938	0	0
SNRPB2	6629	broad.mit.edu	37	20	16717952	16717952	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr20:16717952G>T	uc002wph.1	+	4	500	c.284G>T	c.(283-285)CGT>CTT	p.R95L	SNRPB2_uc002wpi.1_Missense_Mutation_p.R95L	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	95						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						TCAAAAATGCGTGGAACTTTT	0.323			NA											3	28					0.004672	0.00481575	0.004672	1	0
NFS1	9054	broad.mit.edu	37	20	34260738	34260738	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr20:34260738C>G	uc002xdw.1	-	12	1313	c.1249G>C	c.(1249-1251)GAG>CAG	p.E417Q	CPNE1_uc002xdn.1_RNA|CPNE1_uc002xdo.1_RNA|CPNE1_uc002xdp.1_RNA|NFS1_uc002xdt.1_Missense_Mutation_p.E357Q|NFS1_uc002xdu.1_Missense_Mutation_p.E357Q|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_Missense_Mutation_p.E215Q|NFS1_uc010zvl.1_Missense_Mutation_p.E366Q	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	417					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TCCACTTCCTCCTCTGTAGTG	0.453			NA											3	55					0	0	0.004672	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012195	27012195	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr22:27012195C>T	uc003acy.1	-	2	159	c.89G>A	c.(88-90)GGA>GAA	p.G30E		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	30	N-terminal arm.				visual perception		structural constituent of eye lens			ovary(1)	1						AGGGGATGTTCCTGCAGGTGG	0.657			NA											5	86					0	0	0.02938	0	0
SETD2	29072	broad.mit.edu	37	3	47103747	47103747	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr3:47103747T>A	uc003cqs.2	-	14	6252	c.6199A>T	c.(6199-6201)AAG>TAG	p.K2067*	SETD2_uc003cqv.2_Nonsense_Mutation_p.K2134*|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2067					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGAGTTTGCTTGTCTGGGTCT	0.478			NA	N|F|S|Mis		clear cell renal carcinoma								123	304					0	0	0.048971	0	0
QRICH1	54870	broad.mit.edu	37	3	49095083	49095083	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr3:49095083C>A	uc010hkq.2	-	4	846	c.550G>T	c.(550-552)GAA>TAA	p.E184*	QRICH1_uc003cvu.2_Nonsense_Mutation_p.E184*|QRICH1_uc003cvv.2_Nonsense_Mutation_p.E184*	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	184	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TCCGGGATTTCTGCAGCCTGG	0.602			NA											5	66					0.00116845	0.00126267	0.021553	1	0
KIAA1211	57482	broad.mit.edu	37	4	57189582	57189582	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr4:57189582C>G	uc003hbk.2	+	9	3618	c.3227C>G	c.(3226-3228)TCC>TGC	p.S1076C	KIAA1211_uc010iha.2_Missense_Mutation_p.S1069C	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1076										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					TTAGATGGCTCCAAACTTACA	0.507			NA											4	40					0	0	0.014758	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54711811	54711811	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr5:54711811G>C	uc003jpy.3	+	25	3088	c.2822G>C	c.(2821-2823)AGA>ACA	p.R941T	SKIV2L2_uc011cqi.1_Missense_Mutation_p.R840T	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	941					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGTGCTAAAAGAATTGCAAAA	0.343	Melanoma(2;92 134 23744 29976 33782)		NA											3	51					0	0	0.004672	0	0
HMGCR	3156	broad.mit.edu	37	5	74646703	74646703	+	Silent	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr5:74646703A>G	uc003kdp.2	+	9	1026	c.870A>G	c.(868-870)TCA>TCG	p.S290S	HMGCR_uc011cst.1_Silent_p.S310S|HMGCR_uc003kdq.2_Silent_p.S290S|HMGCR_uc010izn.1_Silent_p.S91S	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	290					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CTAAGGTTTCATTAGGACTGG	0.383			NA											7	103					0	0	0.038147	0	0
SHPRH	257218	broad.mit.edu	37	6	146266576	146266576	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr6:146266576T>A	uc003qlf.2	-	8	1918	c.1519A>T	c.(1519-1521)ACT>TCT	p.T507S	SHPRH_uc003qld.2_Missense_Mutation_p.T507S|SHPRH_uc003qle.2_Missense_Mutation_p.T507S|SHPRH_uc003qlg.1_Missense_Mutation_p.T63S|SHPRH_uc003qlj.1_Missense_Mutation_p.T396S	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	507	H15.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AATGTAAAAGTCCCAGAAAAA	0.358			NA											6	74					0	0	0.021553	0	0
MYCT1	80177	broad.mit.edu	37	6	153043209	153043209	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr6:153043209C>T	uc003qpd.3	+	2	537	c.529C>T	c.(529-531)CCT>TCT	p.P177S	MYCT1_uc010kjc.1_Missense_Mutation_p.P129S|MYCT1_uc003qpc.3_Missense_Mutation_p.P177S	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	177						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TCCACCACTTCCTGTGGAAAC	0.493			NA											10	58					0	0	0.080935	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86526912	86526912	+	Missense_Mutation	SNP	G	G	T	rs147564059		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr7:86526912G>T	uc011kha.1	-	19	2780	c.2595C>A	c.(2593-2595)TTC>TTA	p.F865L	KIAA1324L_uc003uif.1_Missense_Mutation_p.F625L|KIAA1324L_uc011kgz.1_Missense_Mutation_p.F751L|KIAA1324L_uc003uie.2_Missense_Mutation_p.F698L	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	865	Extracellular (Potential).					integral to membrane		p.F625F(1)		ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					ACAGGAAATAGAACGTACACC	0.458			NA											5	53					0.00198382	0.00207681	0.02938	1	0
CROT	54677	broad.mit.edu	37	7	86998766	86998766	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr7:86998766G>A	uc003uit.2	+	7	867	c.622G>A	c.(622-624)GAA>AAA	p.E208K	CROT_uc003uiu.2_Missense_Mutation_p.E236K	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	208					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGTAATACATGAAGGATGTTT	0.423			NA											11	150					0	0	0.105934	0	0
LRP12	29967	broad.mit.edu	37	8	105509340	105509340	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr8:105509340G>A	uc003yma.2	-	5	1535	c.1440C>T	c.(1438-1440)AGC>AGT	p.S480S	LRP12_uc003ymb.2_Silent_p.S461S|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	480	Extracellular (Potential).|LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTTCTTCATCGCTGCCATCAC	0.448			NA											5	89					0	0	0.021553	0	0
EFR3A	23167	broad.mit.edu	37	8	132996391	132996391	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr8:132996391G>A	uc003yte.2	+	15	1782	c.1581G>A	c.(1579-1581)GGG>GGA	p.G527G		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	527						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CTCAGAATGGGCAACAGCTGT	0.348			NA											3	60					0	0	0.004672	0	0
KANK1	23189	broad.mit.edu	37	9	732583	732583	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr9:732583G>A	uc003zgl.1	+	10	3860	c.3211G>A	c.(3211-3213)GAA>AAA	p.E1071K	KANK1_uc003zgm.2_3'UTR|KANK1_uc003zgn.1_Missense_Mutation_p.E1071K|KANK1_uc003zgs.1_Missense_Mutation_p.E913K|KANK1_uc010mgx.1_Missense_Mutation_p.E26K|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1071					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GCAGGTTCAAGAATGTGAACC	0.488			NA											4	64					0	0	0.009096	0	0
DAPK1	1612	broad.mit.edu	37	9	90220046	90220046	+	Silent	SNP	C	C	T	rs36207429		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr9:90220046C>T	uc004apc.2	+	3	378	c.240C>T	c.(238-240)CAC>CAT	p.H80H	DAPK1_uc004ape.2_Silent_p.H80H|DAPK1_uc004apd.2_Silent_p.H80H|DAPK1_uc011ltg.1_Silent_p.H80H|DAPK1_uc011lth.1_Translation_Start_Site	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	80	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TCACCCTGCACGAGGTCTATG	0.622			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				12	32					0	0	0.09319	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644506	74644506	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chrX:74644506G>C	uc004ecg.2	-	8	1195	c.717C>G	c.(715-717)AGC>AGG	p.S239R	ZDHHC15_uc004ech.2_Missense_Mutation_p.S230R|ZDHHC15_uc011mqo.1_RNA	NM_144969	NP_659406	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15 isoform 1	239						integral to membrane	zinc ion binding			ovary(2)	2						TTTTGTTTCTGCTGACAAGCC	0.378			NA											6	43					0	0	0.047766	0	0
ALG13	79868	broad.mit.edu	37	X	110961491	110961491	+	Silent	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chrX:110961491A>G	uc011msy.1	+	10	1273	c.1239A>G	c.(1237-1239)TCA>TCG	p.S413S	ALG13_uc011msx.1_Silent_p.S309S|ALG13_uc011msz.1_Silent_p.S335S|ALG13_uc011mta.1_Silent_p.S309S|ALG13_uc011mtb.1_Silent_p.S309S			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	413					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						ACAAGAGTTCAAATCAGAATA	0.249			NA											2	13					0	0	0.009096	0	0
ATF6	22926	broad.mit.edu	37	1	161816357	161816357	+	Frame_Shift_Del	DEL	A	A	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:161816357delA	uc001gbr.2	+	10	1373	c.1306delA	c.(1306-1308)AAAfs	p.K436fs	ATF6_uc001gbq.1_Frame_Shift_Del_p.K436fs	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	436	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TATTATCCAGAAAAACAGCTA	0.403			NA											42	117	---	---	---	---	NA	NA	NA	NA	NA
PPPDE1	51029	broad.mit.edu	37	1	244868886	244868886	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:244868886delG	uc001iao.2	+	5	644	c.380delG	c.(379-381)TGGfs	p.W127fs	PPPDE1_uc001iap.2_Frame_Shift_Del_p.W94fs|PPPDE1_uc001iaq.1_RNA	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	127	PPPDE peptidase.									breast(3)	3						ATTCCTCGCTGGATCAATCGA	0.507			NA											8	131	---	---	---	---	NA	NA	NA	NA	NA
CC2D2B	387707	broad.mit.edu	37	10	97776014	97776017	+	Frame_Shift_Del	DEL	TTTC	TTTC	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	TTTC	TTTC	-	-	TTTC	TTTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:97776014_97776017delTTTC	uc001kll.2	+	6	664_667	c.465_468delTTTC	c.(463-468)AATTTCfs	p.N155fs	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Frame_Shift_Del_p.N155fs	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	155_156										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TTCTCTGTAATTTCTTTCTGTATT	0.382			NA											7	69	---	---	---	---	NA	NA	NA	NA	NA
ACACB	32	broad.mit.edu	37	12	109698333	109698333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:109698333delT	uc001tob.2	+	48	6664	c.6545delT	c.(6544-6546)CTTfs	p.L2182fs	ACACB_uc001toc.2_Frame_Shift_Del_p.L2182fs|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Frame_Shift_Del_p.L848fs	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2182	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GTGGACGGCCTTAGACAATAC	0.552			NA											49	119	---	---	---	---	NA	NA	NA	NA	NA
APEX1	328	broad.mit.edu	37	14	20925518	20925520	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	ATG	ATG	-	-	ATG	ATG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr14:20925518_20925520delATG	uc001vxg.2	+	5	1140_1142	c.808_810delATG	c.(808-810)ATGdel	p.M271del	OSGEP_uc001vxf.2_5'Flank|APEX1_uc001vxh.2_In_Frame_Del_p.M271del|APEX1_uc001vxi.2_In_Frame_Del_p.M271del|APEX1_uc001vxj.2_In_Frame_Del_p.M271del	NM_001641	NP_001632	P27695	APEX1_HUMAN	APEX nuclease 1	271					base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			ovary(2)|breast(2)	4	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	TTGGACTTATATGATGAATGCTC	0.502			NA						Direct_reversal_of_damage|Other_BER_factors					51	164	---	---	---	---	NA	NA	NA	NA	NA
ZNF675	171392	broad.mit.edu	37	19	23845871	23845872	+	Frame_Shift_Ins	INS	-	-	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:23845871_23845872insT	uc002nri.2	-	2	274_275	c.92_93insA	c.(91-93)AATfs	p.N31fs		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	31	KRAB.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTAAAATCACATTTTTATATAA	0.327			NA											7	189	---	---	---	---	NA	NA	NA	NA	NA
