Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6211173	6211173	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:6211173T>A	uc001amb.1	-	7	1013	c.913A>T	c.(913-915)AGC>TGC	p.S305C		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	305					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTGTGGATGCTGGCGCTGTCG	0.597			NA											9	38					0	0	0.010729	0	0
NOL9	79707	broad.mit.edu	37	1	6586755	6586755	+	Splice_Site	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:6586755C>A	uc001ans.2	-	11	1978	c.1959_splice	c.e11+1	p.Q653_splice	NOL9_uc010nzs.1_Splice_Site	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9						maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGGCTCACCTGGCACTTA	0.577			NA											12	75					4.36969e-10	6.07798e-10	0.001855	1	0
SLC45A1	50651	broad.mit.edu	37	1	8395557	8395557	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:8395557C>T	uc001apb.2	+	5	1504	c.1504C>T	c.(1504-1506)CGC>TGC	p.R502C	SLC45A1_uc001apc.2_Missense_Mutation_p.R200C	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	502					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCAGCGAGCGCGCGGAGCA	0.642			NA											4	61					0	0	0.009096	0	0
APITD1	378708	broad.mit.edu	37	1	10511509	10511509	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:10511509C>G	uc001arf.2	+	5	768	c.352C>G	c.(352-354)CAG>GAG	p.Q118E	APITD1_uc001arg.2_3'UTR|CORT_uc001ari.2_Missense_Mutation_p.Q109E	NM_198544	NP_940946	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	Error:Variant_position_missing_in_Q8N2Z9_after_alignment					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GTGGACCTCCCAGGCCAGTGC	0.607			NA											3	40					0	0	0.000602	0	0
TARDBP	23435	broad.mit.edu	37	1	11078853	11078853	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:11078853G>A	uc001art.2	+	4	600	c.466G>A	c.(466-468)GAA>AAA	p.E156K	TARDBP_uc010oap.1_Missense_Mutation_p.E40K	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	156	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		TACGGAATATGAAACACAAGT	0.398			NA											20	91					0	0	0.012319	0	0
LUZP1	7798	broad.mit.edu	37	1	23418999	23418999	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:23418999T>G	uc001bgk.2	-	4	2140	c.1756A>C	c.(1756-1758)AAT>CAT	p.N586H	LUZP1_uc010odv.1_Missense_Mutation_p.N586H|LUZP1_uc001bgl.2_Missense_Mutation_p.N586H|LUZP1_uc001bgm.1_Missense_Mutation_p.N586H	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	586						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TCAAGGCCATTGGCAGCCTTT	0.498			NA											10	55					0	0	0.008291	0	0
MYOM3	127294	broad.mit.edu	37	1	24421445	24421445	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:24421445C>A	uc001bin.3	-	9	989	c.826G>T	c.(826-828)GTG>TTG	p.V276L	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.V276L|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	276	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGCTTCAGCACCGAGGTGAAT	0.537			NA											10	23					3.86212e-05	4.46541e-05	0.008291	1	0
COL16A1	1307	broad.mit.edu	37	1	32119252	32119252	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:32119252T>C	uc001btk.1	-	70	4925	c.4560A>G	c.(4558-4560)AAA>AAG	p.K1520K	COL16A1_uc001bti.1_Silent_p.K134K|COL16A1_uc001btj.1_Silent_p.K1318K	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1520	Triple-helical region 1 (COL1) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CAATGTCCCCTTTTTCACCTT	0.448	Colon(143;498 1786 21362 25193 36625)		NA											2	40					0	0	0.004672	0	0
DLGAP3	58512	broad.mit.edu	37	1	35334520	35334520	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:35334520G>T	uc001byc.2	-	7	2171	c.2171C>A	c.(2170-2172)ACC>AAC	p.T724N		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	724					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				GACTGAGTAGGTGGGGGCCCG	0.687			NA											7	40					1.12685e-05	1.33642e-05	0.004482	1	0
EPHA10	284656	broad.mit.edu	37	1	38227478	38227478	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:38227478C>T	uc009vvi.2	-	3	535	c.449G>A	c.(448-450)CGC>CAC	p.R150H	EPHA10_uc001cbw.3_Missense_Mutation_p.R150H	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	150	Extracellular (Potential).		R -> H (in a gastric adenocarcinoma sample; somatic mutation).			extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity	p.R150H(1)		breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTCGATTTTGCGGGGCCGGCT	0.667			NA											7	29					0	0	0.001984	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713140	48713140	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:48713140C>T	uc001cro.2	+	14	2023	c.1971C>T	c.(1969-1971)CTC>CTT	p.L657L	SLC5A9_uc001crn.2_Silent_p.L682L|SLC5A9_uc010omt.1_Silent_p.L671L|SLC5A9_uc001crp.2_Silent_p.L324L|SLC5A9_uc010omu.1_Silent_p.L324L|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	657	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						AGGAGCCACTCTGGAGACATG	0.547			NA											4	75					0	0	0.000602	0	0
C8B	732	broad.mit.edu	37	1	57420395	57420395	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:57420395A>G	uc001cyp.2	-	4	564	c.497T>C	c.(496-498)ATG>ACG	p.M166T	C8B_uc010oon.1_Missense_Mutation_p.M104T|C8B_uc010ooo.1_Missense_Mutation_p.M114T	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	166	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						GTATTGGTCCATTTCATGCTG	0.448			NA											12	88					0	0	0.001855	0	0
SGIP1	84251	broad.mit.edu	37	1	67147567	67147567	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:67147567C>A	uc001dcr.2	+	15	1047	c.830C>A	c.(829-831)GCC>GAC	p.A277D	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.A44D	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	277	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding	p.A277D(1)		ovary(3)	3						GACCAGTCAGCCACAGAGGTC	0.403			NA											17	100					9.16793e-09	1.22387e-08	0.00499	1	0
IL23R	149233	broad.mit.edu	37	1	67724488	67724488	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:67724488A>T	uc001ddo.2	+	11	1652	c.1567A>T	c.(1567-1569)AGG>TGG	p.R523W	IL23R_uc009waz.2_Missense_Mutation_p.R320W|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Missense_Mutation_p.R121W|IL23R_uc010opk.1_3'UTR|IL23R_uc010opl.1_Missense_Mutation_p.R105W|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Missense_Mutation_p.R269W|IL23R_uc010opn.1_Missense_Mutation_p.R368W|IL23R_uc001ddr.2_RNA|IL23R_uc010ops.1_Missense_Mutation_p.R320W|IL23R_uc010opt.1_Missense_Mutation_p.R164W|IL23R_uc010opu.1_Missense_Mutation_p.R219W|IL23R_uc010opv.1_Missense_Mutation_p.R281W|IL23R_uc010opw.1_Missense_Mutation_p.R158W|IL23R_uc010opx.1_Missense_Mutation_p.R164W|IL23R_uc010opy.1_Missense_Mutation_p.R290W|IL23R_uc010opz.1_Missense_Mutation_p.R164W|IL23R_uc010oqa.1_Missense_Mutation_p.R164W|IL23R_uc010oqb.1_Missense_Mutation_p.R352W|IL23R_uc010oqc.1_Missense_Mutation_p.R239W|IL23R_uc010oqd.1_Missense_Mutation_p.R158W|IL23R_uc010oqe.1_Missense_Mutation_p.R121W|IL23R_uc010oqf.1_Missense_Mutation_p.R121W|IL23R_uc010oqg.1_Missense_Mutation_p.R121W|IL23R_uc010oqh.1_Missense_Mutation_p.R164W|IL23R_uc001dds.2_Missense_Mutation_p.R268W|IL23R_uc001ddt.2_Missense_Mutation_p.R121W	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	523	Cytoplasmic (Potential).				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						AAATAATCCCAGGTTACAAAA	0.343			NA											13	25					0	0	0.001855	0	0
PTGFR	5737	broad.mit.edu	37	1	78958727	78958727	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:78958727G>T	uc001din.2	+	2	565	c.299G>T	c.(298-300)CGC>CTC	p.R100L	PTGFR_uc001dim.2_Missense_Mutation_p.R100L	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	100	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GAATGGATCCGCTTTGACCAA	0.448			NA											6	81					3.59834e-05	4.18376e-05	0.001168	1	0
GBP5	115362	broad.mit.edu	37	1	89735212	89735212	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:89735212G>T	uc001dnc.2	-	3	564	c.27C>A	c.(25-27)GAC>GAA	p.D9E	GBP5_uc001dnd.2_Missense_Mutation_p.D9E|GBP5_uc001dne.1_Missense_Mutation_p.D9E	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	9						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		GGCACATGGGGTCTGACATGT	0.453			NA											15	116					1.15088e-07	1.46331e-07	0.004007	1	0
LPPR4	9890	broad.mit.edu	37	1	99764761	99764761	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:99764761G>C	uc001dse.2	+	4	815	c.709G>C	c.(709-711)GAC>CAC	p.D237H	LPPR4_uc010oue.1_Missense_Mutation_p.D237H	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	237							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTCAGGATCTGACCTCACAGT	0.378			NA											10	34					0	0	0.013537	0	0
WDR47	22911	broad.mit.edu	37	1	109538225	109538225	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:109538225C>A	uc001dwj.2	-	8	2044	c.1668G>T	c.(1666-1668)GAG>GAT	p.E556D	WDR47_uc001dwl.2_Missense_Mutation_p.E564D|WDR47_uc001dwi.2_Missense_Mutation_p.E557D|WDR47_uc001dwk.2_Missense_Mutation_p.E528D|WDR47_uc010ovf.1_Missense_Mutation_p.E483D	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	556										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		AAGGTGATTCCTCCAGAAAAG	0.383			NA											18	151					9.7654e-05	0.000110444	0.007413	1	0
CYB561D1	284613	broad.mit.edu	37	1	110038606	110038606	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:110038606G>A	uc010ovn.1	+	3	476	c.415G>A	c.(415-417)GCT>ACT	p.A139T	CYB561D1_uc010ovl.1_Missense_Mutation_p.A82T|CYB561D1_uc010ovm.1_Missense_Mutation_p.A81T|CYB561D1_uc001dxu.2_3'UTR|CYB561D1_uc001dxw.2_3'UTR|CYB561D1_uc010ovo.1_Missense_Mutation_p.A161T|CYB561D1_uc009wfd.2_Missense_Mutation_p.A88T|CYB561D1_uc010ovp.1_Missense_Mutation_p.A73T	NM_182580	NP_872386	Q8N8Q1	C56D1_HUMAN	cytochrome b-561 domain containing 1 isoform 2	139	Cytochrome b561.|Helical; (Potential).				electron transport chain|transport	integral to membrane	metal ion binding				0		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0422)|Epithelial(280;0.0655)|all cancers(265;0.0685)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCTGGCCACTGCTGTCCAGGC	0.632			NA											8	58					0	0	0.006214	0	0
MAN1A2	10905	broad.mit.edu	37	1	118065453	118065453	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:118065453G>A	uc001ehd.1	+	13	2521	c.1800G>A	c.(1798-1800)TTG>TTA	p.L600L		NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	600	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TCAGATATTTGTATCTGCTGT	0.403	Ovarian(33;199 881 8228 13687 31538)		NA											8	70					0	0	0.006214	0	0
SPAG17	200162	broad.mit.edu	37	1	118635849	118635849	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:118635849C>G	uc001ehk.2	-	8	1171	c.1103G>C	c.(1102-1104)AGC>ACC	p.S368T		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	368						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAGCTGCATGCTTTCCAAATA	0.418			NA											9	27					0	0	0.010729	0	0
NOTCH2	4853	broad.mit.edu	37	1	120466285	120466285	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:120466285C>T	uc001eik.2	-	26	5090	c.4834G>A	c.(4834-4836)GGT>AGT	p.G1612S		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1612	Negative regulatory region (NRR).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTGTTCACCAGGAAGGGAT	0.468			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				14	77					0	0	0.003163	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882694	144882694	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:144882694G>T	uc001elw.3	-	24	3616	c.3325C>A	c.(3325-3327)CTG>ATG	p.L1109M	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.L116M	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1109	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCATTCTTCAGTTTTCCCTGG	0.473			NA	T	PDGFRB	MPD								61	188					6.5469e-37	1.19021e-36	0.01441	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244			NA											5	89					0	0	0.000602	0	0
BCL9	607	broad.mit.edu	37	1	147096596	147096596	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:147096596G>A	uc001epq.2	+	10	4857	c.4117G>A	c.(4117-4119)GGG>AGG	p.G1373R	BCL9_uc010ozr.1_Missense_Mutation_p.G1287R	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1373	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CACCCACCCTGGGCCTGTGGG	0.637			NA	T	IGH@|IGL@	B-ALL								7	52					0	0	0.00308	0	0
SF3B4	10262	broad.mit.edu	37	1	149895789	149895789	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:149895789G>C	uc001etj.1	-	5	1082	c.1031C>G	c.(1030-1032)CCT>CGT	p.P344R	SF3B4_uc001eti.1_Missense_Mutation_p.P108R|SF3B4_uc001etk.1_Missense_Mutation_p.P344R	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	344						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AGGAGGTCCAGGATGAGGCAT	0.632			NA											4	25					0	0	0.000602	0	0
VPS72	6944	broad.mit.edu	37	1	151157999	151157999	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:151157999T>A	uc001exe.1	-	3	411	c.368A>T	c.(367-369)CAA>CTA	p.Q123L	VPS72_uc001exf.1_Missense_Mutation_p.Q123L	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	123					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCGTCATCTTGTAGTTCTAA	0.328	Pancreas(109;1131 2287 3209 24201)		NA											58	373					0	0	0.01441	0	0
SELENBP1	8991	broad.mit.edu	37	1	151337030	151337030	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:151337030T>G	uc001exx.2	-	12	1455	c.1408A>C	c.(1408-1410)ATC>CTC	p.I470L	SELENBP1_uc010pcy.1_Missense_Mutation_p.I512L|SELENBP1_uc001exy.2_Missense_Mutation_p.I367L|SELENBP1_uc001exz.2_Missense_Mutation_p.I367L|SELENBP1_uc010pcz.1_Missense_Mutation_p.I408L|SELENBP1_uc009wms.2_Missense_Mutation_p.I306L|SELENBP1_uc009wmt.2_Missense_Mutation_p.I367L|SELENBP1_uc001eya.2_Missense_Mutation_p.I406L|SELENBP1_uc009wmu.2_3'UTR	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	470					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAAATCCAGATGTCAGAGCTA	0.587			NA											25	147					0	0	0.005443	0	0
HRNR	388697	broad.mit.edu	37	1	152191695	152191695	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152191695A>T	uc001ezt.1	-	3	2486	c.2410T>A	c.(2410-2412)TGT>AGT	p.C804S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	804	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAATGGCCACAGCTGGAAGAA	0.582			NA											14	67					0	0	0.00245	0	0
FLG	2312	broad.mit.edu	37	1	152281967	152281967	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152281967C>T	uc001ezu.1	-	3	5431	c.5395G>A	c.(5395-5397)GAC>AAC	p.D1799N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1799	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTCGTGCCTGC	0.602			NA							Ichthyosis				35	543					0	0	0.004878	0	0
FLG	2312	broad.mit.edu	37	1	152282329	152282329	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152282329C>G	uc001ezu.1	-	3	5069	c.5033G>C	c.(5032-5034)GGA>GCA	p.G1678A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1678	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCTTTCTCCTGGACTTGA	0.557			NA							Ichthyosis				16	806					0	0	0.008871	0	0
FLG	2312	broad.mit.edu	37	1	152283290	152283290	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152283290C>T	uc001ezu.1	-	3	4108	c.4072G>A	c.(4072-4074)GGA>AGA	p.G1358R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1358	Ser-rich.|Filaggrin 8.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCGGGATCCATGTCTTTCT	0.547			NA							Ichthyosis				109	735					0	0	0.01441	0	0
FLG2	388698	broad.mit.edu	37	1	152328162	152328162	+	Silent	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152328162T>G	uc001ezw.3	-	3	2173	c.2100A>C	c.(2098-2100)TCA>TCC	p.S700S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	700	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGATTGACTTGAGCCAAAAC	0.468			NA											83	583					0	0	0.01441	0	0
LCE1C	353133	broad.mit.edu	37	1	152777708	152777708	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152777708G>A	uc001fap.1	-	2	298	c.247C>T	c.(247-249)CGT>TGT	p.R83C		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	83	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGGACCTACGGCGCCTGTGG	0.701			NA											11	94					0	0	0.00245	0	0
LCE1C	353133	broad.mit.edu	37	1	152777762	152777762	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:152777762C>A	uc001fap.1	-	2	244	c.193G>T	c.(193-195)GGG>TGG	p.G65W		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	65	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGCATCCCCCAGAGCTGGAG	0.612			NA											12	149					4.36969e-10	6.07798e-10	0.001855	1	0
ASH1L	55870	broad.mit.edu	37	1	155330133	155330133	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:155330133T>A	uc009wqq.2	-	13	7249	c.6769A>T	c.(6769-6771)ACT>TCT	p.T2257S	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.T2252S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2257	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TAATCATAAGTGAGTTCAGTC	0.368			NA											7	122					0	0	0.010729	0	0
SMG5	23381	broad.mit.edu	37	1	156222835	156222835	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:156222835T>A	uc001foc.3	-	18	2686	c.2537A>T	c.(2536-2538)CAG>CTG	p.Q846L	SMG5_uc009wrv.2_Missense_Mutation_p.Q331L	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	846					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GGCCTTGGGCTGCTGCAGGCT	0.672			NA											3	19					0	0	0.004672	0	0
NES	10763	broad.mit.edu	37	1	156642334	156642334	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:156642334A>G	uc001fpq.2	-	4	1779	c.1646T>C	c.(1645-1647)CTG>CCG	p.L549P		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	549	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCCTCTCCCAGAGACTTCAG	0.458			NA											23	31					0	0	0.003954	0	0
CD1E	913	broad.mit.edu	37	1	158325717	158325717	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:158325717G>A	uc001fse.2	+	4	965	c.726G>A	c.(724-726)GTG>GTA	p.V242V	CD1E_uc010pid.1_Silent_p.V240V|CD1E_uc010pie.1_Silent_p.V143V|CD1E_uc010pif.1_Silent_p.V53V|CD1E_uc001fsd.2_Silent_p.V242V|CD1E_uc001fsk.2_Silent_p.V152V|CD1E_uc001fsj.2_Silent_p.V152V|CD1E_uc001fsc.2_Silent_p.V53V|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Silent_p.V53V|CD1E_uc001fsf.2_Silent_p.V242V|CD1E_uc001fry.2_Silent_p.V242V|CD1E_uc001fsg.2_Silent_p.V53V|CD1E_uc001fsh.2_Silent_p.V53V|CD1E_uc001fsi.2_Silent_p.V242V|CD1E_uc009wsv.2_Silent_p.V143V|CD1E_uc001frz.2_Silent_p.V152V|CD1E_uc009wsw.2_5'UTR	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	242	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CCGTGTGGGTGATGTGGATGC	0.627			NA											15	182					0	0	0.00499	0	0
SPTA1	6708	broad.mit.edu	37	1	158623125	158623125	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:158623125G>A	uc001fst.1	-	22	3326	c.3127C>T	c.(3127-3129)CCA>TCA	p.P1043S		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1043					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CGCCGCTGTGGGAGCATCGGG	0.552			NA											25	123					0	0	0.00632	0	0
VSIG8	391123	broad.mit.edu	37	1	159832278	159832278	+	Missense_Mutation	SNP	C	C	A	rs142337981		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:159832278C>A	uc001fuh.2	-	1	170	c.34G>T	c.(34-36)GTG>TTG	p.V12L		NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	12						integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CTCAGGCACACGAGTAGAAGG	0.627			NA											15	210					1.64113e-05	1.92161e-05	0.010504	1	0
CASQ1	844	broad.mit.edu	37	1	160164819	160164819	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:160164819G>A	uc010pja.1	+	4	740	c.483G>A	c.(481-483)GTG>GTA	p.V161V		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	161						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGACCCTGTGGAATTGATTG	0.478			NA											7	67					0	0	0.004482	0	0
LY9	4063	broad.mit.edu	37	1	160797585	160797585	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:160797585T>A	uc001fwu.2	+	10	1997	c.1947T>A	c.(1945-1947)CCT>CCA	p.P649P	LY9_uc001fwv.2_Silent_p.P635P|LY9_uc001fww.2_Silent_p.P559P|LY9_uc001fwx.2_Silent_p.P536P|LY9_uc001fwz.2_Silent_p.P264P	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	649	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTGAAAGTCCTACCTATGAAA	0.493			NA											18	158					0	0	0.012319	0	0
NOS1AP	9722	broad.mit.edu	37	1	162337182	162337182	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:162337182G>T	uc001gbv.2	+	10	1833	c.1446G>T	c.(1444-1446)GAG>GAT	p.E482D	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.E477D|NOS1AP_uc009wut.1_Missense_Mutation_p.E187D	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	482					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GGTCCCAGGAGGAGCTGCCGC	0.647			NA											9	6					1.58986e-06	1.94395e-06	0.008291	1	0
LMX1A	4009	broad.mit.edu	37	1	165322350	165322350	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:165322350G>T	uc001gcy.1	-	2	447	c.226C>A	c.(226-228)CGG>AGG	p.R76R	LMX1A_uc001gcz.1_Silent_p.R76R	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	76	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R76L(1)		central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TTCTTGTCCCGGTAGAAGCAG	0.602			NA											14	121					6.72482e-11	9.67861e-11	0.003163	1	0
MAEL	84944	broad.mit.edu	37	1	166985467	166985467	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:166985467G>C	uc001gdy.1	+	9	925	c.854G>C	c.(853-855)TGG>TCG	p.W285S	MAEL_uc001gdz.1_Missense_Mutation_p.W254S|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	285					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AGGTGCAAGTGGCATGAAGAA	0.328			NA											33	53					0	0	0.007835	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509543	171509543	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:171509543G>A	uc010pmg.1	+	16	3198	c.2932G>A	c.(2932-2934)GGA>AGA	p.G978R	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	978							protein C-terminus binding				0						ATCTTCTGAAGGACCAAAACC	0.403			NA											6	6					0	0	0.001168	0	0
RC3H1	149041	broad.mit.edu	37	1	173949963	173949963	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:173949963T>A	uc001gju.3	-	5	1040	c.953A>T	c.(952-954)CAG>CTG	p.Q318L	RC3H1_uc010pms.1_Missense_Mutation_p.Q318L|RC3H1_uc001gjv.2_Missense_Mutation_p.Q318L|RC3H1_uc010pmt.1_Missense_Mutation_p.Q318L	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	318					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AATAATGGACTGCATATGAGA	0.388			NA											14	26					0	0	0.001855	0	0
TNR	7143	broad.mit.edu	37	1	175375626	175375626	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:175375626C>A	uc001gkp.1	-	1	306	c.225G>T	c.(223-225)TTG>TTT	p.L75F	TNR_uc009wwu.1_Missense_Mutation_p.L75F|TNR_uc010pmz.1_Missense_Mutation_p.L75F	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	75					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AGAGGTTGTCCAAGGGCACGT	0.562			NA											16	129					2.23348e-06	2.71888e-06	0.004007	1	0
ASTN1	460	broad.mit.edu	37	1	177001936	177001936	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:177001936A>T	uc001glc.2	-	3	733	c.521T>A	c.(520-522)CTG>CAG	p.L174Q	ASTN1_uc001glb.1_Missense_Mutation_p.L174Q|ASTN1_uc001gld.1_Missense_Mutation_p.L174Q|ASTN1_uc009wwx.1_Missense_Mutation_p.L174Q|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	174	Helical; (Potential).				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GCGAGTATACAGGATCATCAC	0.582			NA											9	85					0	0	0.006214	0	0
FAM5B	57795	broad.mit.edu	37	1	177242683	177242683	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:177242683C>T	uc001glf.2	+	5	1041	c.729C>T	c.(727-729)GTC>GTT	p.V243V	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Silent_p.V138V	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	243						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGGACTCAGTCAGTTCTGTCT	0.443			NA											11	54					0	0	0.013537	0	0
FAM5B	57795	broad.mit.edu	37	1	177250364	177250364	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:177250364G>T	uc001glf.2	+	8	2364	c.2052G>T	c.(2050-2052)CAG>CAT	p.Q684H	FAM5B_uc001glg.2_Missense_Mutation_p.Q579H	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	684						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ACACCTTGCAGGTCTTTGGCT	0.478			NA											21	128					2.32416e-17	3.8381e-17	0.014323	1	0
C1orf125	126859	broad.mit.edu	37	1	179504063	179504064	+	Missense_Mutation	DNP	GT	GT	TA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:179504063_179504064GT>TA	uc001gmo.2	+	25	3124_3125	c.2997_2998GT>TA	c.(2995-3000)AGGTCA>AGTACA	p.999_1000RS>ST	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.925_926RS>ST|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	999_1000	Glu-rich.										0						aagaagTCAGGTCAGCAGAAAA	0.238			NA											5	51					0	0	0.004672	0	0
CACNA1E	777	broad.mit.edu	37	1	181705478	181705478	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:181705478G>T	uc001gow.2	+	22	3495	c.3330G>T	c.(3328-3330)GAG>GAT	p.E1110D	CACNA1E_uc009wxs.2_Missense_Mutation_p.E998D|CACNA1E_uc001gox.1_Missense_Mutation_p.E336D|CACNA1E_uc009wxt.2_Missense_Mutation_p.E336D	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1110	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						atgaggaggaggtggagaaga	0.398			NA											7	20					3.09899e-07	3.88075e-07	0.004482	1	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:186276981A>G	uc001gru.3	+	7	2181	c.2130A>G	c.(2128-2130)AAA>AAG	p.K710K	PRG4_uc001grt.3_Silent_p.K669K|PRG4_uc009wyl.2_Silent_p.K617K|PRG4_uc009wym.2_Silent_p.K576K|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|43; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTACCCCTAAAGGGACTGCTC	0.582			NA											4	181					0	0	0.009096	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186909147	186909147	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:186909147A>T	uc001gsc.2	+	10	1159	c.954A>T	c.(952-954)AAA>AAT	p.K318N	PLA2G4A_uc010pos.1_Missense_Mutation_p.K258N	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	318	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TGAAGGAAAAAGTTAATACTG	0.373			NA											20	111					0	0	0.00278	0	0
FAM5C	339479	broad.mit.edu	37	1	190068084	190068084	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:190068084G>T	uc001gse.1	-	8	1597	c.1365C>A	c.(1363-1365)GAC>GAA	p.D455E	FAM5C_uc010pot.1_Missense_Mutation_p.D353E	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	455						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GGGTGCGGTTGTCTGGTGCGC	0.627			NA											34	56					2.46105e-21	4.25044e-21	0.010818	1	0
RGS18	64407	broad.mit.edu	37	1	192153519	192153519	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:192153519T>A	uc001gsg.2	+	5	719	c.543T>A	c.(541-543)TAT>TAA	p.Y181*		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	181	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						GCAGAGTGTATCAGCTCATGG	0.398			NA											14	106					0	0	0.00499	0	0
KCNT2	343450	broad.mit.edu	37	1	196227384	196227384	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:196227384C>A	uc001gtd.1	-	26	3211	c.3151G>T	c.(3151-3153)GAG>TAG	p.E1051*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.E984*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.E1027*|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Nonsense_Mutation_p.E555*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1051	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCAGCAAGCTCTTGTCTTTCT	0.423			NA											39	44					5.7616e-29	1.03161e-28	0.01441	1	0
ASPM	259266	broad.mit.edu	37	1	197070775	197070775	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:197070775C>A	uc001gtu.2	-	18	7863	c.7606G>T	c.(7606-7608)GTT>TTT	p.V2536F	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.V384F	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2536	IQ 27.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GCCTGAATAACCACAGCAGAA	0.343			NA											5	96					5.18039e-06	6.22398e-06	0.00308	1	0
ASPM	259266	broad.mit.edu	37	1	197073662	197073662	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:197073662T>C	uc001gtu.2	-	18	4976	c.4719A>G	c.(4717-4719)AGA>AGG	p.R1573R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1573					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTCTGTCTTGTCTCATTCTCC	0.338			NA											7	27					0	0	0.006214	0	0
CRB1	23418	broad.mit.edu	37	1	197390932	197390932	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:197390932C>A	uc001gtz.2	+	6	2109	c.1974C>A	c.(1972-1974)ATC>ATA	p.I658I	CRB1_uc010poz.1_Silent_p.I589I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.I546I|CRB1_uc010ppb.1_Silent_p.I658I|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Silent_p.I139I|CRB1_uc001gub.1_Silent_p.I307I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	658	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TGGAGAACATCTCGTCTGGCT	0.443			NA											20	160					9.86323e-18	1.6386e-17	0.003954	1	0
PTPRC	5788	broad.mit.edu	37	1	198721820	198721820	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:198721820T>C	uc001gur.1	+	31	3602	c.3422T>C	c.(3421-3423)GTC>GCC	p.V1141A	PTPRC_uc001gus.1_Missense_Mutation_p.V1093A|PTPRC_uc001gut.1_Missense_Mutation_p.V980A	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1141	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ATGATTCAGGTCGTCAAACAA	0.448			NA											19	34					0	0	0.006122	0	0
KIF14	9928	broad.mit.edu	37	1	200522757	200522757	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:200522757T>A	uc010ppk.1	-	30	5145	c.4706A>T	c.(4705-4707)CAG>CTG	p.Q1569L	KIF14_uc010ppj.1_Missense_Mutation_p.Q1078L	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1569	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCTAGTTCCTGGTGGACAAT	0.398			NA											35	37					0	0	0.005524	0	0
LMOD1	25802	broad.mit.edu	37	1	201869373	201869373	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:201869373T>C	uc001gxb.2	-	2	1016	c.768A>G	c.(766-768)AAA>AAG	p.K256K	LMOD1_uc010ppu.1_Silent_p.K205K	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	256	8 X approximate tandem repeats.|6.				muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						CAGTTCCTCTTTTTACCTTCT	0.408			NA											9	25					0	0	0.010729	0	0
CDK18	5129	broad.mit.edu	37	1	205495550	205495550	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:205495550C>T	uc001hcr.2	+	7	936	c.717C>T	c.(715-717)ATC>ATT	p.I239I	CDK18_uc010pri.1_3'UTR|CDK18_uc001hcp.2_Silent_p.I209I|CDK18_uc001hcq.2_Silent_p.I209I|CDK18_uc010prj.1_Silent_p.I120I|CDK18_uc001hcs.2_Silent_p.I120I|CDK18_uc009xbm.1_Silent_p.I120I|CDK18_uc001hct.2_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	207	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						ATGACCTCATCCACACAGATC	0.587	Pancreas(180;489 2072 28461 40831 44265)		NA											9	271					0	0	0.004482	0	0
C1orf116	79098	broad.mit.edu	37	1	207198390	207198390	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:207198390A>C	uc001hfd.2	-	3	384	c.125T>G	c.(124-126)TTC>TGC	p.F42C	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	42						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					AGTGGACAGGAAGTCGTAGCT	0.363			NA											28	47					0	0	0.009535	0	0
C4BPB	725	broad.mit.edu	37	1	207265092	207265092	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:207265092C>T	uc001hfj.2	+	4	466	c.336C>T	c.(334-336)ATC>ATT	p.I112I	C4BPB_uc001hfi.2_Silent_p.I111I|C4BPB_uc001hfk.2_Silent_p.I111I|C4BPB_uc001hfl.2_Silent_p.I112I|C4BPB_uc009xcd.2_Silent_p.I102I|C4BPB_uc001hfm.2_Silent_p.I112I|C4BPB_uc010pse.1_Silent_p.I102I	NM_001017365	NP_001017365	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	112	Sushi 2.				blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				ovary(1)	1						ACCACTACATCCTCAAGGGCA	0.488			NA											9	92					0	0	0.004482	0	0
HHAT	55733	broad.mit.edu	37	1	210761424	210761424	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:210761424C>T	uc009xcx.2	+	10	1392	c.1226C>T	c.(1225-1227)CCC>CTC	p.P409L	HHAT_uc010psq.1_Missense_Mutation_p.P272L|HHAT_uc001hhz.3_Missense_Mutation_p.P409L|HHAT_uc010psr.1_Missense_Mutation_p.P410L|HHAT_uc010pss.1_Missense_Mutation_p.P364L|HHAT_uc009xcy.2_Missense_Mutation_p.P344L|HHAT_uc010pst.1_Missense_Mutation_p.P346L|HHAT_uc010psu.1_Missense_Mutation_p.P344L|HHAT_uc001hia.3_Missense_Mutation_p.P99L	NM_001122834	NP_001116306	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	409					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		GTGGAGACTCCCTGCATCCAG	0.577			NA											12	12					0	0	0.013537	0	0
KCNH1	3756	broad.mit.edu	37	1	210971016	210971016	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:210971016C>A	uc001hib.2	-	9	1919	c.1749G>T	c.(1747-1749)CGG>CGT	p.R583R	KCNH1_uc001hic.2_Silent_p.R556R	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	583	Cytoplasmic (Potential).|cNMP.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CACTGGCCAGCCGGAAGGCCG	0.622			NA											36	39					9.17885e-22	1.59523e-21	0.003271	1	0
INTS7	25896	broad.mit.edu	37	1	212180034	212180034	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:212180034G>A	uc001hiw.1	-	7	931	c.826C>T	c.(826-828)CTG>TTG	p.L276L	INTS7_uc009xdb.1_Silent_p.L276L|INTS7_uc001hix.1_Silent_p.L152L|INTS7_uc001hiy.1_Silent_p.L276L|INTS7_uc010pta.1_Silent_p.L227L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	276					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		AGTAATTTCAGATCTTGAATA	0.303			NA											5	75					0	0	0.001168	0	0
KCNK2	3776	broad.mit.edu	37	1	215368369	215368369	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:215368369C>A	uc001hkq.2	+	6	1066	c.897C>A	c.(895-897)TAC>TAA	p.Y299*	KCNK2_uc001hko.2_Nonsense_Mutation_p.Y295*|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Nonsense_Mutation_p.Y284*	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	299	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	GGCTTGCTTACTTTGCTGCTG	0.398			NA											27	237					6.00712e-18	1.00401e-17	0.012213	1	0
USH2A	7399	broad.mit.edu	37	1	216500977	216500977	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:216500977T>A	uc001hku.1	-	5	1191	c.804A>T	c.(802-804)GGA>GGT	p.G268G	USH2A_uc001hkv.2_Silent_p.G268G	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	268	Extracellular (Potential).		G -> R (in USH2A; uncertain pathogenicity).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTGCATTCTTCCGACAAACT	0.363			NA								HNSCC(13;0.011)			55	93					0	0	0.01441	0	0
ESRRG	2104	broad.mit.edu	37	1	216850617	216850617	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:216850617C>A	uc001hkw.1	-	2	439	c.273G>T	c.(271-273)CTG>CTT	p.L91L	ESRRG_uc001hky.1_Silent_p.L68L|ESRRG_uc009xdp.1_Silent_p.L68L|ESRRG_uc001hkz.1_Silent_p.L68L|ESRRG_uc010puc.1_Silent_p.L68L|ESRRG_uc001hla.1_Silent_p.L68L|ESRRG_uc001hlb.1_Silent_p.L68L|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.L68L|ESRRG_uc001hld.1_Silent_p.L68L|ESRRG_uc001hkx.1_Silent_p.L96L|ESRRG_uc009xdo.1_Silent_p.L68L|ESRRG_uc001hle.1_Silent_p.L68L	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	91					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CACTACCTCCCAGGATAGGAG	0.532			NA											20	132					7.87624e-14	1.21364e-13	0.00278	1	0
PRSS38	339501	broad.mit.edu	37	1	228033677	228033677	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:228033677T>C	uc001hrh.2	+	5	749	c.749T>C	c.(748-750)GTC>GCC	p.V250A		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	250	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						GGCCCACTTGTCTGTGAATTC	0.582			NA											6	99					0	0	0.001984	0	0
URB2	9816	broad.mit.edu	37	1	229773083	229773083	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:229773083G>T	uc001hts.1	+	4	2859	c.2723G>T	c.(2722-2724)AGC>ATC	p.S908I	URB2_uc009xfd.1_Missense_Mutation_p.S908I	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	908						nucleolus				central_nervous_system(2)|ovary(1)	3						CAGCTGGACAGCCTCTTGCCA	0.512			NA											30	285					1.414e-09	1.92165e-09	0.003755	1	0
ERO1LB	56605	broad.mit.edu	37	1	236399088	236399088	+	Splice_Site	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:236399088C>A	uc001hxt.2	-	8	929	c.673_splice	c.e8+1	p.G225_splice		NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta						electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GAAAAACCTACCTCGGCTAGG	0.294			NA											27	29					1.1423e-28	2.04088e-28	0.009535	1	0
RYR2	6262	broad.mit.edu	37	1	237947492	237947492	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:237947492G>T	uc001hyl.1	+	90	12600	c.12480G>T	c.(12478-12480)TGG>TGT	p.W4160C	RYR2_uc010pya.1_Missense_Mutation_p.W575C	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4160					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAACCCAGTGGGAGAAGCCCC	0.498			NA											13	152					6.72482e-11	9.67861e-11	0.003163	1	0
FMN2	56776	broad.mit.edu	37	1	240371243	240371243	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:240371243C>A	uc010pyd.1	+	5	3356	c.3131C>A	c.(3130-3132)CCG>CAG	p.P1044Q	FMN2_uc010pye.1_Missense_Mutation_p.P1048Q	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1044	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATACCCCCTCCGCCCCCACTT	0.731			NA											45	108					5.02462e-34	9.11469e-34	0.01441	1	0
OR2B11	127623	broad.mit.edu	37	1	247614852	247614852	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:247614852A>C	uc010pyx.1	-	1	433	c.433T>G	c.(433-435)TGT>GGT	p.C145G		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGCTGCTGACAGAGAGCACGG	0.642			NA											8	81					0	0	0.008291	0	0
OR2W5	441932	broad.mit.edu	37	1	247654948	247654948	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:247654948G>T	uc001icz.1	+	1	519	c.519G>T	c.(517-519)AGG>AGT	p.R173S		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GACGTCGCAGGGTGGACCACT	0.567			NA											26	131					7.01153e-11	1.00738e-10	0.007291	1	0
OR2C3	81472	broad.mit.edu	37	1	247694880	247694880	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:247694880C>A	uc009xgy.2	-	2	1296	c.934G>T	c.(934-936)GGC>TGC	p.G312C	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CCTGCAGAGCCACAGCAGTTC	0.522			NA											10	47					0.000673444	0.000743389	0.008291	1	0
OR2G2	81470	broad.mit.edu	37	1	247751915	247751915	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:247751915T>A	uc010pyy.1	+	1	254	c.254T>A	c.(253-255)CTG>CAG	p.L85Q		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCCCAGCTCCTGGTAAACCTG	0.517			NA											4	135					0	0	0.009096	0	0
TRIM58	25893	broad.mit.edu	37	1	248039556	248039556	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248039556G>T	uc001ido.2	+	6	1274	c.1226G>T	c.(1225-1227)CGC>CTC	p.R409L	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	409	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAAAGTCCTCGCTGCATTGGG	0.478			NA											37	303					2.1956e-27	3.89754e-27	0.004289	1	0
OR2W3	343171	broad.mit.edu	37	1	248059502	248059502	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248059502G>T	uc001idp.1	+	3	883	c.614G>T	c.(613-615)GGT>GTT	p.G205V	OR2W3_uc010pzb.1_Missense_Mutation_p.G205V	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTGGCGGTGGGTGTTGTGCTG	0.577			NA											23	270					1.66031e-10	2.34479e-10	0.003954	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129115	248129115	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248129115C>A	uc010pzd.1	+	1	482	c.482C>A	c.(481-483)GCA>GAA	p.A161E	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTCATGGTTGCATGTGCATGG	0.413	Melanoma(45;390 1181 23848 28461 41504)		NA											26	320					1.04121e-07	1.34032e-07	0.005443	1	0
OR2L2	26246	broad.mit.edu	37	1	248201698	248201698	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248201698C>A	uc001idw.2	+	1	225	c.129C>A	c.(127-129)TCC>TCA	p.S43S	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GAAATCTATCCATGATTCTTC	0.388			NA											42	388					7.88023e-25	1.38994e-24	0.01441	1	0
OR2L13	284521	broad.mit.edu	37	1	248263103	248263103	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248263103G>T	uc001ids.2	+	3	763	c.426G>T	c.(424-426)AAG>AAT	p.K142N		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGTGTGTGAAGATGATTGGAG	0.488			NA											30	383					9.65021e-13	1.4572e-12	0.010818	1	0
OR2L13	284521	broad.mit.edu	37	1	248263467	248263467	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248263467C>A	uc001ids.2	+	3	1127	c.790C>A	c.(790-792)CTC>ATC	p.L264I		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GCCCAGGAATCTCCGCTCACC	0.468			NA											71	157					3.20846e-33	5.80746e-33	0.01441	1	0
OR2M2	391194	broad.mit.edu	37	1	248344072	248344072	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248344072C>A	uc010pzf.1	+	1	785	c.785C>A	c.(784-786)CCC>CAC	p.P262H		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACATACGGCCCACATCTGAT	0.517			NA											30	258					1.26612e-14	1.99926e-14	0.003271	1	0
OR2M2	391194	broad.mit.edu	37	1	248344078	248344078	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248344078C>A	uc010pzf.1	+	1	791	c.791C>A	c.(790-792)TCT>TAT	p.S264Y		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CGGCCCACATCTGATCACTCC	0.522			NA											32	251					1.47244e-24	2.58614e-24	0.00623	1	0
OR2M3	127062	broad.mit.edu	37	1	248366722	248366722	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248366722T>A	uc010pzg.1	+	1	353	c.353T>A	c.(352-354)ATG>AAG	p.M118K		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTGGCTGTTATGGCTTATGAC	0.453			NA											45	285					0	0	0.01441	0	0
OR2T2	401992	broad.mit.edu	37	1	248616713	248616714	+	Missense_Mutation	DNP	GC	GC	TA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:248616713_248616714GC>TA	uc001iek.1	+	1	615_616	c.615_616GC>TA	c.(613-618)GTGCTG>GTTATG	p.L206M		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTGCGTGCTGATGCTGCT	0.53			NA											30	67					0	0	0.004672	0	0
AKR1E2	83592	broad.mit.edu	37	10	4872896	4872896	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:4872896G>A	uc001ihi.2	+	2	184	c.69G>A	c.(67-69)GTG>GTA	p.V23V	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Silent_p.V23V|AKR1E2_uc001ihh.1_Silent_p.V23V|AKR1E2_uc009xhw.2_Silent_p.V23V|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Silent_p.V23V	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	23						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CCGAGGCAGTGAAAGAGGCCA	0.502	NSCLC(43;343 1097 20371 28813 45509)		NA											7	87					0	0	0.004482	0	0
ITIH5	80760	broad.mit.edu	37	10	7683904	7683904	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:7683904G>A	uc001ijq.2	-	3	364	c.285C>T	c.(283-285)ATC>ATT	p.I95I	ITIH5_uc001ijr.1_Silent_p.I95I	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	95	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TGAAGTTGGTGATGAAAGCTG	0.507			NA											6	103					0	0	0.006214	0	0
ITGA8	8516	broad.mit.edu	37	10	15559227	15559227	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:15559227C>A	uc001ioc.1	-	30	3122	c.3122G>T	c.(3121-3123)AGA>ATA	p.R1041I	ITGA8_uc010qcb.1_Missense_Mutation_p.R1026I	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	1041	Cytoplasmic (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AGGTCTGGCTCTGTCAAAGAA	0.433			NA											9	35					4.68919e-08	6.06449e-08	0.008291	1	0
CACNB2	783	broad.mit.edu	37	10	18787304	18787304	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:18787304G>C	uc001ipr.2	+	4	414	c.354G>C	c.(352-354)GCG>GCC	p.A118A	CACNB2_uc009xjz.1_Silent_p.A118A|CACNB2_uc001ips.2_Silent_p.A118A|CACNB2_uc001ipt.2_Silent_p.A118A|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Silent_p.A90A|CACNB2_uc001ipv.2_Silent_p.A90A|CACNB2_uc009xka.1_Silent_p.A90A|CACNB2_uc001ipw.2_Silent_p.A63A|CACNB2_uc001ipx.2_Silent_p.A63A|CACNB2_uc009xkb.1_Silent_p.A64A|CACNB2_uc010qcm.1_Silent_p.A64A|CACNB2_uc001ipz.2_Silent_p.A64A|CACNB2_uc001ipy.2_Silent_p.A64A|CACNB2_uc010qcn.1_Silent_p.A70A|CACNB2_uc010qco.1_Silent_p.A70A|CACNB2_uc001iqa.2_Silent_p.A70A	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	118	SH3.				axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTGCATTTGCGGTTCGGACAA	0.448			NA											7	34					0	0	0.004482	0	0
BMI1	648	broad.mit.edu	37	10	22615878	22615878	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:22615878G>T	uc001irh.2	+	3	811	c.172G>T	c.(172-174)GTC>TTC	p.V58F	BMI1_uc009xkg.2_Missense_Mutation_p.V201F	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	58					hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						TATTTGTGATGTCCAAGTTCA	0.343			NA											24	111					9.80776e-20	1.65931e-19	0.00632	1	0
KIAA1217	56243	broad.mit.edu	37	10	24832540	24832540	+	Missense_Mutation	SNP	C	C	G	rs140457046	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:24832540C>G	uc001iru.3	+	19	4744	c.4341C>G	c.(4339-4341)TTC>TTG	p.F1447L	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.F1130L|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.F283L	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1447					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TCATCATTTTCGATGAGCCCA	0.413			NA											20	68					0	0	0.00632	0	0
SVIL	6840	broad.mit.edu	37	10	29813479	29813479	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:29813479C>T	uc001iut.1	-	14	3261	c.2508G>A	c.(2506-2508)CGG>CGA	p.R836R	SVIL_uc010qdw.1_5'Flank|SVIL_uc001iuu.1_Silent_p.R410R	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	836					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CTATTCTGTTCCGGGTAGAAA	0.498			NA											19	73					0	0	0.012319	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508039	37508039	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:37508039T>G	uc001iza.1	+	34	3330	c.3231T>G	c.(3229-3231)TTT>TTG	p.F1077L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1133	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATAAATACTTTGAGGACATTA	0.338			NA											22	67					0	0	0.00278	0	0
RASSF4	83937	broad.mit.edu	37	10	45488724	45488724	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:45488724G>T	uc001jbo.2	+	11	1047	c.913G>T	c.(913-915)GCC>TCC	p.A305S	RASSF4_uc001jbp.2_Missense_Mutation_p.A336S|RASSF4_uc009xmn.2_Missense_Mutation_p.A235S|RASSF4_uc001jbq.2_Missense_Mutation_p.A202S|RASSF4_uc001jbt.2_Missense_Mutation_p.A262S	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	305	SARAH.				cell cycle|signal transduction		protein binding			large_intestine(1)	1						CAGGTTCCAAGCCCTGCGTCT	0.627			NA											7	27					1.76689e-08	2.31765e-08	0.006214	1	0
RBP3	5949	broad.mit.edu	37	10	48390663	48390663	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:48390663C>A	uc001jez.2	-	1	329	c.215G>T	c.(214-216)AGT>ATT	p.S72I		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	72	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TGTCAGCACACTGGCCAGCGT	0.622			NA											10	64					0.000442599	0.000490528	0.006214	1	0
FRMPD2	143162	broad.mit.edu	37	10	49393668	49393668	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:49393668T>A	uc001jgi.2	-	18	2394	c.2287A>T	c.(2287-2289)AAG>TAG	p.K763*	FRMPD2_uc001jgh.2_Nonsense_Mutation_p.K731*|FRMPD2_uc001jgj.2_Nonsense_Mutation_p.K741*	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	763					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		ATAAAGCTCTTCCTCCTATTA	0.463			NA											13	61					0	0	0.004007	0	0
PCDH15	65217	broad.mit.edu	37	10	55782702	55782702	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:55782702C>G	uc001jju.1	-	19	2871	c.2476G>C	c.(2476-2478)GTC>CTC	p.V826L	PCDH15_uc010qhq.1_Missense_Mutation_p.V831L|PCDH15_uc010qhr.1_Missense_Mutation_p.V826L|PCDH15_uc010qhs.1_Missense_Mutation_p.V838L|PCDH15_uc010qht.1_Missense_Mutation_p.V833L|PCDH15_uc010qhu.1_Missense_Mutation_p.V826L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.V826L|PCDH15_uc010qhw.1_Missense_Mutation_p.V789L|PCDH15_uc010qhx.1_Missense_Mutation_p.V755L|PCDH15_uc010qhy.1_Missense_Mutation_p.V831L|PCDH15_uc010qhz.1_Missense_Mutation_p.V826L|PCDH15_uc010qia.1_Missense_Mutation_p.V804L|PCDH15_uc010qib.1_Missense_Mutation_p.V804L|PCDH15_uc001jjw.2_Missense_Mutation_p.V826L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	826	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCAACAAGGACAGTGTATGTT	0.418			NA								HNSCC(58;0.16)			28	111					0	0	0.009535	0	0
BICC1	80114	broad.mit.edu	37	10	60588583	60588583	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:60588583G>T	uc001jki.1	+	21	2857	c.2857G>T	c.(2857-2859)GGT>TGT	p.G953C		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	953					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TTTCCTGGAAGGTGGAGCGAG	0.493			NA											8	49					4.68919e-08	6.06449e-08	0.008291	1	0
ZNF365	22891	broad.mit.edu	37	10	64136238	64136238	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:64136238C>A	uc001jmc.2	+	2	601	c.286C>A	c.(286-288)CCG>ACG	p.P96T	ZNF365_uc001jly.3_Missense_Mutation_p.P111T|ZNF365_uc001jmb.3_Missense_Mutation_p.P96T|ZNF365_uc001jlz.3_Missense_Mutation_p.P96T|ZNF365_uc001jma.3_Intron	NM_199451	NP_955523	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform C	55										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					AAAGCAGAAACCGAGCTATGT	0.483			NA											15	62					2.31682e-05	2.70133e-05	0.003163	1	0
CTNNA3	29119	broad.mit.edu	37	10	69407230	69407230	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:69407230C>A	uc009xpn.1	-	2	165	c.42G>T	c.(40-42)CAG>CAT	p.Q14H	CTNNA3_uc001jmw.2_Missense_Mutation_p.Q14H|CTNNA3_uc001jmx.3_Missense_Mutation_p.Q14H|CTNNA3_uc009xpo.1_Translation_Start_Site|CTNNA3_uc001jna.2_Missense_Mutation_p.Q26H	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	14					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CCTGCAGATCCTGAGGATCGA	0.388			NA											25	81					2.81731e-10	3.95187e-10	0.010818	1	0
DLG5	9231	broad.mit.edu	37	10	79616594	79616594	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:79616594C>T	uc001jzk.2	-	3	500	c.430G>A	c.(430-432)GAG>AAG	p.E144K	DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	144					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCCACCTTCTCATTCACTTGC	0.522			NA											11	13					0	0	0.013537	0	0
NRG3	10718	broad.mit.edu	37	10	83635516	83635516	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:83635516C>A	uc001kco.2	+	1	447	c.420C>A	c.(418-420)CCC>CCA	p.P140P	NRG3_uc010qlz.1_Silent_p.P140P|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	140	Ser/Thr-rich.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ccgccaccccctccgccGGGG	0.527			NA											11	13					6.40141e-05	7.33993e-05	0.010729	1	0
BTAF1	9044	broad.mit.edu	37	10	93723909	93723909	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:93723909A>G	uc001khr.2	+	13	1578	c.1480A>G	c.(1480-1482)ATG>GTG	p.M494V	BTAF1_uc001khs.1_Missense_Mutation_p.M164V|BTAF1_uc001kht.1_5'Flank	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	494					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AAATAGTATTATGACTCTCCT	0.333			NA											19	66					0	0	0.012319	0	0
PLCE1	51196	broad.mit.edu	37	10	96006295	96006295	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:96006295C>G	uc001kjk.2	+	8	3647	c.3013C>G	c.(3013-3015)CTC>GTC	p.L1005V	PLCE1_uc010qnx.1_Missense_Mutation_p.L1005V|PLCE1_uc001kjm.2_Missense_Mutation_p.L697V	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1005					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATTATTGGAACTCACTAGAGC	0.478			NA											13	79					0	0	0.00245	0	0
C10orf129	142827	broad.mit.edu	37	10	96967138	96967138	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:96967138T>A	uc001kke.2	+	4	702	c.577T>A	c.(577-579)TAT>AAT	p.Y193N	C10orf129_uc009xuu.1_Missense_Mutation_p.Y103N	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	acyl-coenzyme A synthetase ACSM6, mitochondrial	193					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		AGATAAGAGCTATGATGGGTG	0.433			NA											17	64					0	0	0.008871	0	0
CPN1	1369	broad.mit.edu	37	10	101841176	101841176	+	Silent	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:101841176A>G	uc001kql.2	-	1	467	c.207T>C	c.(205-207)CCT>CCC	p.P69P		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	69	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CGTGGATTCCAGGGTGGTCGC	0.577			NA											10	19					0	0	0.013537	0	0
C10orf26	54838	broad.mit.edu	37	10	104572912	104572912	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:104572912G>T	uc001kwe.3	+	4	1113	c.853G>T	c.(853-855)GAC>TAC	p.D285Y	C10orf26_uc001kwf.3_Missense_Mutation_p.D306Y|C10orf26_uc009xxg.1_Intron	NM_017787	NP_060257	Q9NX94	OPA1L_HUMAN	hypothetical protein LOC54838 isoform 2	285						integral to membrane				central_nervous_system(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;6.14e-09)|all cancers(201;1.66e-07)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGACTTCTGCGACAGCTGCCA	0.612			NA											14	65					1.52009e-12	2.28289e-12	0.003163	1	0
ATRNL1	26033	broad.mit.edu	37	10	117093890	117093890	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:117093890G>A	uc001lcg.2	+	19	3522	c.3136G>A	c.(3136-3138)GGT>AGT	p.G1046S	ATRNL1_uc010qsm.1_Intron|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1046	Laminin EGF-like 1.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGTATGCCAGGTTATTATGG	0.373			NA											10	60					0	0	0.013537	0	0
INPP5F	22876	broad.mit.edu	37	10	121563689	121563689	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:121563689T>C	uc001leo.2	+	10	1287	c.1121T>C	c.(1120-1122)ATT>ACT	p.I374T		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	374	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TTATAGGTTATTATTAACTTG	0.338			NA											3	60					0	0	0.004672	0	0
DHX32	55760	broad.mit.edu	37	10	127569112	127569112	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:127569112C>A	uc001ljf.1	-	1	773	c.282G>T	c.(280-282)CAG>CAT	p.Q94H	DHX32_uc001ljg.1_Missense_Mutation_p.Q94H	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	94	Helicase ATP-binding.					mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GGTTACTCACCTGAGCGCTCT	0.328			NA											10	35					1.08611e-07	1.38734e-07	0.010729	1	0
ADAM8	101	broad.mit.edu	37	10	135086508	135086508	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:135086508G>C	uc010qva.1	-	6	523	c.472C>G	c.(472-474)CGA>GGA	p.R158G	ADAM8_uc010quz.1_Missense_Mutation_p.R197G|ADAM8_uc009ybi.2_Missense_Mutation_p.R197G|ADAM8_uc010qvb.1_Missense_Mutation_p.R172G|ADAM8_uc009ybj.1_RNA			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	158					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CGGGTCTCTCGGGATGGCAGA	0.682			NA											19	102					0	0	0.012319	0	0
PDDC1	347862	broad.mit.edu	37	11	773602	773602	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:773602G>C	uc001lrc.2	-	4	300	c.275C>G	c.(274-276)CCC>CGC	p.P92R	PDDC1_uc010qwm.1_Missense_Mutation_p.P42R|PDDC1_uc001lrd.2_Missense_Mutation_p.P92R|PDDC1_uc001lrf.1_Intron|PDDC1_uc001lrg.1_Intron|PDDC1_uc009ycg.2_Missense_Mutation_p.P42R|PDDC1_uc010qwn.1_RNA|PDDC1_uc010qwo.1_RNA|PDDC1_uc010qwp.1_Intron|PDDC1_uc010qwq.1_Intron|PDDC1_uc010qwr.1_Missense_Mutation_p.P92R|PDDC1_uc010qws.1_Missense_Mutation_p.P42R	NM_182612	NP_872418	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	92						extracellular region					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGACAGCTGGGGATCAGGAG	0.647			NA											7	21					0	0	0.006214	0	0
MUC5B	727897	broad.mit.edu	37	11	1266056	1266056	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:1266056C>A	uc009ycr.1	+	48	9986	c.9860C>A	c.(9859-9861)CCC>CAC	p.P3287H	MUC5B_uc001ltb.2_Missense_Mutation_p.P2652H	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2649	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACGGTGACCCCCTCCTCCATC	0.632			NA											29	55					3.67414e-24	6.43946e-24	0.012213	1	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606012	1606012	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:1606012G>A	uc001ltu.1	-	1	502	c.468C>T	c.(466-468)GGC>GGT	p.G156G	LOC338651_uc009ycx.1_Intron|LOC338651_uc001ltt.1_Intron	NM_001005922	NP_001005922	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	156	8 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGGAGCCACAGCCCCCTTTGC	0.652			NA											32	232					0	0	0.004289	0	0
OR52K1	390036	broad.mit.edu	37	11	4510775	4510775	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:4510775T>G	uc001lza.1	+	1	645	c.645T>G	c.(643-645)TTT>TTG	p.F215L		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACCTGCTCTTTGTTATCCTGT	0.498			NA											28	203					0	0	0.008361	0	0
OR51L1	119682	broad.mit.edu	37	11	5020422	5020422	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:5020422G>T	uc010qyu.1	+	1	210	c.210G>T	c.(208-210)GTG>GTT	p.V70V		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTAGCAGTGAATGACCTGG	0.453			NA											26	72					3.99451e-17	6.57033e-17	0.009535	1	0
HBE1	3046	broad.mit.edu	37	11	5291054	5291054	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:5291054C>T	uc001mal.1	-	1	320	c.67G>A	c.(67-69)GAG>AAG	p.E23K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Missense_Mutation_p.E23K	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	23					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCCAGCCTCTTCCACATTC	0.502			NA											4	60					0	0	0.001168	0	0
UBQLN3	50613	broad.mit.edu	37	11	5528910	5528911	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:5528910_5528911CC>GA	uc001may.1	-	2	1964_1965	c.1878_1879GG>TC	c.(1876-1881)ATGGGC>ATTCGC	p.626_627MG>IR	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	626_627	UBA.									ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCAGAAAGCCCATGGACCGCA	0.54	Ovarian(72;684 1260 12332 41642 52180)		NA											28	73					0	0	0.004672	0	0
OR52N2	390077	broad.mit.edu	37	11	5841574	5841574	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:5841574G>T	uc010qzp.1	+	1	9	c.9G>T	c.(7-9)GGG>GGT	p.G3G	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G3E(1)		ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATGTCTGGGGACAACAGCT	0.502			NA											6	90					0.00198382	0.00215825	0.001984	1	0
CCKBR	887	broad.mit.edu	37	11	6291332	6291332	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:6291332G>T	uc001mcp.2	+	3	611	c.418G>T	c.(418-420)GTG>TTG	p.V140L	CCKBR_uc001mcq.2_Missense_Mutation_p.V68L|CCKBR_uc001mcr.2_Missense_Mutation_p.V140L|CCKBR_uc001mcs.2_Missense_Mutation_p.V140L	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	140	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GTCTGTGAGTGTGTCCACGCT	0.602			NA											10	42					1.08611e-07	1.38734e-07	0.010729	1	0
TUB	7275	broad.mit.edu	37	11	8060537	8060537	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:8060537G>T	uc001mfy.2	+	1	358	c.117G>T	c.(115-117)AGG>AGT	p.R39S	TUB_uc010rbk.1_Intron	NM_003320	NP_003311	P50607	TUB_HUMAN	tubby isoform a	Error:Variant_position_missing_in_P50607_after_alignment					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGCAGCACAGGAAACCTGGGC	0.557			NA											5	57					2.0095e-06	2.44981e-06	0.001984	1	0
GALNTL4	374378	broad.mit.edu	37	11	11362386	11362386	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:11362386C>A	uc001mjo.2	-	7	1679	c.1258G>T	c.(1258-1260)GCA>TCA	p.A420S		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	420	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		ATGTTCCATGCCATGTAGACG	0.522			NA											23	247					4.26978e-12	6.30953e-12	0.00333	1	0
PDE3B	5140	broad.mit.edu	37	11	14882866	14882866	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:14882866T>A	uc001mln.2	+	14	3193	c.2840T>A	c.(2839-2841)TTG>TAG	p.L947*	PDE3B_uc010rcr.1_Nonsense_Mutation_p.L896*	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	947	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GTTCGAGACTTGCATTTGAAA	0.413			NA											14	125					0	0	0.003163	0	0
PDE3B	5140	broad.mit.edu	37	11	14882896	14882896	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:14882896A>T	uc001mln.2	+	14	3223	c.2870A>T	c.(2869-2871)AAT>ATT	p.N957I	PDE3B_uc010rcr.1_Missense_Mutation_p.N906I	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	957	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GGCATTGTCAATGAATTTTAT	0.413			NA											13	120					0	0	0.001855	0	0
SAAL1	113174	broad.mit.edu	37	11	18103035	18103035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:18103035C>A	uc001mnq.2	-	11	1305	c.1255G>T	c.(1255-1257)GGA>TGA	p.G419*	SAAL1_uc001mnr.2_Nonsense_Mutation_p.G418*|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Nonsense_Mutation_p.G421*	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	419					acute-phase response	extracellular region	binding				0						TCCTTTACTCCCTGAGCCACC	0.358			NA											8	69					7.48243e-07	9.27195e-07	0.006214	1	0
TMEM86A	144110	broad.mit.edu	37	11	18722737	18722737	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:18722737C>T	uc001moz.1	+	2	362	c.279C>T	c.(277-279)TTC>TTT	p.F93F		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	93	Helical; (Potential).					integral to membrane				ovary(1)	1						AAGGATACTTCGTGCATGGTC	0.587			NA											8	97					0	0	0.004482	0	0
KCNA4	3739	broad.mit.edu	37	11	30033634	30033634	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:30033634G>A	uc001msk.2	-	2	1744	c.592C>T	c.(592-594)CCA>TCA	p.P198S		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	198						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAGTCTCTGGAAACTGGGCC	0.483			NA											3	34					0	0	0.004672	0	0
KCNA4	3739	broad.mit.edu	37	11	30033738	30033738	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:30033738C>A	uc001msk.2	-	2	1640	c.488G>T	c.(487-489)GGT>GTT	p.G163V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	163	Poly-Gly.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTAGCCGCCACCGCCCTCATC	0.443			NA											8	77					0.000978159	0.00107832	0.010729	1	0
KCNA4	3739	broad.mit.edu	37	11	30033974	30033974	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:30033974C>T	uc001msk.2	-	2	1404	c.252G>A	c.(250-252)AGG>AGA	p.R84R		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	84				RRRRQ -> EEEAT (in Ref. 1; AAA60034).		voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTCGCCTCCTCCTCCGACTAC	0.632			NA											24	41					0	0	0.005443	0	0
ALKBH3	221120	broad.mit.edu	37	11	43940636	43940636	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:43940636G>T	uc001mxs.2	+	9	1161	c.718G>T	c.(718-720)GAT>TAT	p.D240Y	ALKBH3_uc009ykp.2_RNA|ALKBH3_uc001mxt.2_RNA|ALKBH3_uc009ykq.2_Missense_Mutation_p.D93Y|uc001mxu.1_Intron	NM_139178	NP_631917	Q96Q83	ALKB3_HUMAN	AlkB homolog 3	240	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	GATACCCTTGGATCATGGGAC	0.423			NA						Direct_reversal_of_damage					35	108					5.20837e-25	9.20626e-25	0.00874	1	0
ACCS	84680	broad.mit.edu	37	11	44105101	44105101	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:44105101C>G	uc009yks.1	+	14	1526	c.1382C>G	c.(1381-1383)TCA>TGA	p.S461*	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Nonsense_Mutation_p.S461*	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	461							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						TTTGTCTTCTCAGACCAGGTC	0.572	Esophageal Squamous(158;148 1889 8077 23160 41213)		NA											4	80					0	0	0.000602	0	0
LRP4	4038	broad.mit.edu	37	11	46916274	46916274	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:46916274T>C	uc001ndn.3	-	12	1552	c.1406A>G	c.(1405-1407)AAT>AGT	p.N469S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	469	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GGCAATGGCATTCTCCAGGTT	0.597			NA											33	69					0	0	0.004289	0	0
OR4C13	283092	broad.mit.edu	37	11	49974514	49974514	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:49974514C>A	uc010rhz.1	+	1	540	c.540C>A	c.(538-540)TAC>TAA	p.Y180*		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						GTGATCTCTACACTTTGATCA	0.438			NA											14	122					1.33834e-09	1.82181e-09	0.007413	1	0
TRIM48	79097	broad.mit.edu	37	11	55032584	55032584	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55032584C>T	uc010rid.1	+	2	339	c.253C>T	c.(253-255)CGA>TGA	p.R85*		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	69						intracellular	zinc ion binding				0						AACTAACATTCGATTGAAGAA	0.448			NA											4	59					0	0	0.000602	0	0
OR5D13	390142	broad.mit.edu	37	11	55541053	55541053	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55541053T>G	uc010ril.1	+	1	140	c.140T>G	c.(139-141)ATG>AGG	p.M47R		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				AACTTGGGCATGATAATAATC	0.388			NA											25	84					0	0	0.005443	0	0
OR5D18	219438	broad.mit.edu	37	11	55587535	55587535	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55587535C>T	uc010rin.1	+	1	430	c.430C>T	c.(430-432)CTG>TTG	p.L144L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				ACTCTGCGTGCTGCTGGTTGT	0.463			NA											11	121					0	0	0.00245	0	0
OR5D18	219438	broad.mit.edu	37	11	55587957	55587957	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55587957C>T	uc010rin.1	+	1	852	c.852C>T	c.(850-852)CCC>CCT	p.P284P		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TGGTGATCCCCATGTTGAATC	0.468			NA											8	46					0	0	0.004482	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735790	55735790	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55735790C>A	uc010rit.1	-	1	150	c.150G>T	c.(148-150)ATG>ATT	p.M50I		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	50	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GAAAAAAATACATGGGAGTCT	0.323			NA											15	62					9.16793e-09	1.22387e-08	0.00499	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735793	55735793	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:55735793G>C	uc010rit.1	-	1	147	c.147C>G	c.(145-147)CCC>CCG	p.P49P		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	49	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAAAATACATGGGAGTCTGGA	0.333			NA											15	67					0	0	0.00499	0	0
OR5T2	219464	broad.mit.edu	37	11	56000021	56000021	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:56000021C>A	uc010rjc.1	-	1	641	c.641G>T	c.(640-642)AGG>ATG	p.R214M		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	214	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAAGACACGCCTAATTTCATT	0.428			NA											17	129					1.45105e-14	2.26539e-14	0.006122	1	0
OR5M9	390162	broad.mit.edu	37	11	56230691	56230691	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:56230691G>T	uc010rjj.1	-	1	187	c.187C>A	c.(187-189)CAT>AAT	p.H63N		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					AAAGACAGATGACTCAGGAAA	0.423			NA											7	28					5.18039e-06	6.22398e-06	0.00308	1	0
OR5M3	219482	broad.mit.edu	37	11	56237247	56237247	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:56237247G>A	uc010rjk.1	-	1	727	c.727C>T	c.(727-729)CTG>TTG	p.L243L		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACAGCTGTCAGATGGGACCCA	0.468			NA											7	31					0	0	0.001984	0	0
OR5M10	390167	broad.mit.edu	37	11	56345137	56345137	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:56345137G>A	uc001niz.1	-	1	61	c.61C>T	c.(61-63)CCA>TCA	p.P21S		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTAGCACTGGGTCGTCTGTC	0.458			NA											25	69					0	0	0.010818	0	0
OR1S2	219958	broad.mit.edu	37	11	57970762	57970762	+	Missense_Mutation	SNP	T	T	A	rs139372504		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:57970762T>A	uc010rkb.1	-	1	892	c.892A>T	c.(892-894)ATG>TTG	p.M298L		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	298	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AAGGGGTTCATCATGGGTGTC	0.468			NA											9	116					0	0	0.004482	0	0
OR5B2	390190	broad.mit.edu	37	11	58190619	58190619	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:58190619C>A	uc010rkg.1	-	1	116	c.116G>T	c.(115-117)GGG>GTG	p.G39V		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCCCAGGTTCCCACACAGAGT	0.478			NA											34	78					4.62619e-21	7.95666e-21	0.004289	1	0
CD6	923	broad.mit.edu	37	11	60785403	60785403	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:60785403C>A	uc001nqq.2	+	11	1978	c.1755C>A	c.(1753-1755)CCC>CCA	p.P585P	CD6_uc001nqp.2_Silent_p.P585P|CD6_uc001nqr.2_Silent_p.P553P|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.P544P	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	585	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CATGGAACCCCCAGGTGTTTT	0.582	Pancreas(169;904 2017 4767 38890 42505)		NA											11	97					4.36969e-10	6.07798e-10	0.001855	1	0
TMEM223	79064	broad.mit.edu	37	11	62558318	62558318	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:62558318C>A	uc001nve.2	-	2	406	c.386G>T	c.(385-387)GGA>GTA	p.G129V		NM_001080501	NP_001073970	A0PJW6	TM223_HUMAN	transmembrane protein 223	129						integral to membrane					0						CTGCTGCCCTCCAGCTCGAAG	0.612			NA											6	10					0.00116845	0.00128127	0.001168	1	0
FAU	2197	broad.mit.edu	37	11	64888175	64888175	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:64888175T>A	uc001ocx.2	-	5	487	c.380A>T	c.(379-381)AAG>ATG	p.K127M	FAU_uc001ocy.1_3'UTR|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	Error:Variant_position_missing_in_P35544_after_alignment											0						ATTGGGGCCCTTCTTCTTGCC	0.463			NA											24	36					0	0	0.005443	0	0
ODZ4	26011	broad.mit.edu	37	11	78412943	78412943	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:78412943G>T	uc001ozl.3	-	28	5178	c.4715C>A	c.(4714-4716)ACC>AAC	p.T1572N	ODZ4_uc009yvb.1_Missense_Mutation_p.T156N	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1572	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CATGTTCTGGGTGTTGAGGAA	0.527			NA											25	70					1.39806e-14	2.2034e-14	0.008361	1	0
EED	8726	broad.mit.edu	37	11	85989472	85989472	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:85989472G>C	uc001pbp.2	+	12	1688	c.1231G>C	c.(1231-1233)GCT>CCT	p.A411P	EED_uc001pbq.2_3'UTR|EED_uc001pbr.2_Missense_Mutation_p.A436P|EED_uc001pbs.2_Missense_Mutation_p.A331P	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	411	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.|WD 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				TAAATGTGGTGCTGCTATTCG	0.418			NA											22	76					0	0	0.005443	0	0
CNTN5	53942	broad.mit.edu	37	11	99941257	99941257	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:99941257C>A	uc001pga.2	+	11	1603	c.1264C>A	c.(1264-1266)CGT>AGT	p.R422S	CNTN5_uc009ywv.1_Missense_Mutation_p.R422S|CNTN5_uc001pfz.2_Missense_Mutation_p.R422S|CNTN5_uc001pgb.2_Missense_Mutation_p.R348S	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	422	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACCCACGTATCGTTGGCTGAA	0.468			NA											10	20					1.05317e-09	1.44549e-09	0.00245	1	0
ATM	472	broad.mit.edu	37	11	108183144	108183144	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:108183144T>A	uc001pkb.1	+	40	6310	c.5925T>A	c.(5923-5925)CTT>CTA	p.L1975L	ATM_uc009yxr.1_Silent_p.L1975L|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Silent_p.L627L|ATM_uc001pkg.1_Silent_p.L332L|ATM_uc009yxt.1_Silent_p.L89L	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1975	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ACAGAAGTCTTGCATTTGAAG	0.323			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			9	76					0	0	0.006214	0	0
DDX10	1662	broad.mit.edu	37	11	108594087	108594087	+	Silent	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:108594087A>T	uc001pkm.2	+	13	1928	c.1863A>T	c.(1861-1863)ACA>ACT	p.T621T	DDX10_uc001pkl.1_Silent_p.T621T	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	621							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAGTTCCTACACAGTTCTTGG	0.413			NA	T	NUP98	AML*								14	30					0	0	0.00499	0	0
NCAM1	4684	broad.mit.edu	37	11	113102941	113102941	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:113102941C>A	uc009yyq.1	+	12	1708	c.1014C>A	c.(1012-1014)AAC>AAA	p.N338K		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	430	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GGGAGGGGAACCAGGTGAACA	0.512			NA											6	23					3.59834e-05	4.18376e-05	0.001168	1	0
VPS11	55823	broad.mit.edu	37	11	118944508	118944508	+	Splice_Site	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:118944508A>T	uc010ryx.1	+	8	1129	c.1087_splice	c.e8-2	p.M363_splice	VPS11_uc010ryy.1_Splice_Site_p.M209_splice	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11						protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CTTCCCTTCTAGATGCTGTTT	0.448			NA											3	20					0	0	0.009096	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120348935	120348935	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:120348935G>A	uc001pxl.1	+	37	3610	c.3603G>A	c.(3601-3603)GGG>GGA	p.G1201G	ARHGEF12_uc009zat.2_Silent_p.G1182G|ARHGEF12_uc009zau.1_Silent_p.G1098G	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1201					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GTACCTCTGGGAAATCAGAGG	0.403			NA	T	MLL	AML								5	48					0	0	0.001168	0	0
OR6T1	219874	broad.mit.edu	37	11	123814296	123814296	+	Missense_Mutation	SNP	C	C	A	rs148288062		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:123814296C>A	uc010sab.1	-	1	250	c.250G>T	c.(250-252)GTC>TTC	p.V84F		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGAGGATGACGACAAGCATC	0.502			NA											9	62					3.07112e-06	3.72761e-06	0.010729	1	0
JAM3	83700	broad.mit.edu	37	11	134014219	134014219	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:134014219C>A	uc001qhb.1	+	4	499	c.475C>A	c.(475-477)CGC>AGC	p.R159S	JAM3_uc009zcz.1_Intron	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	114	Extracellular (Potential).|Ig-like V-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		AGCCCTTTATCGCTGTGAGGT	0.498			NA											17	66					7.45023e-12	1.09314e-11	0.010504	1	0
WNK1	65125	broad.mit.edu	37	12	994776	994776	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:994776C>T	uc001qio.3	+	19	5313	c.4806C>T	c.(4804-4806)CCC>CCT	p.P1602P	WNK1_uc001qip.3_Silent_p.P1355P|WNK1_uc001qir.3_Silent_p.P775P	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1602					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTATCCCACCCTTGGTACAGC	0.483	Colon(19;451 567 6672 12618 28860)		NA											27	83					0	0	0.004656	0	0
TEAD4	7004	broad.mit.edu	37	12	3129840	3129840	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:3129840G>T	uc010sej.1	+	9	898	c.621G>T	c.(619-621)GCG>GCT	p.A207A	TEAD4_uc010sek.1_Silent_p.A164A|TEAD4_uc001qln.2_Silent_p.A79A	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	208					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CGCCCTCTGCGCCCCCGGCAC	0.677			NA											21	47					1.96292e-10	2.75807e-10	0.010504	1	0
GALNT8	26290	broad.mit.edu	37	12	4835915	4835915	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:4835915C>T	uc001qne.1	+	2	521	c.429C>T	c.(427-429)CTC>CTT	p.L143L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	143	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CCCAGGACCTCTTCCGGAAGT	0.557	Colon(108;631 1558 7270 20097 39846)		NA											6	79					0	0	0.00308	0	0
KLHDC5	57542	broad.mit.edu	37	12	27944681	27944681	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:27944681G>T	uc001rij.2	+	2	990	c.913G>T	c.(913-915)GCC>TCC	p.A305S	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	305	Kelch 3.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					AAAACTCTATGCCATCGGAGG	0.468			NA											50	141					8.28887e-21	1.41973e-20	0.01441	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43770388	43770389	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:43770388_43770389GG>TT	uc010skx.1	-	33	5063_5064	c.5063_5064CC>AA	c.(5062-5064)TCC>TAA	p.S1688*		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1688	TSP type-1 15.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATAAGTCACTGGACAAACCATG	0.347			NA											7	24					0	0	0.004672	0	0
TUBA1B	10376	broad.mit.edu	37	12	49523382	49523382	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:49523382C>A	uc001rtm.2	-	2	348	c.127G>T	c.(127-129)GGG>TGG	p.G43W	TUBA1B_uc001rto.2_Intron|TUBA1B_uc001rtk.2_Missense_Mutation_p.G8W|TUBA1B_uc001rtl.2_Missense_Mutation_p.G8W|TUBA1B_uc001rtn.2_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	43					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						TCTCCTCCCCCAATGGTCTTG	0.587			NA											15	115					4.14922e-12	6.15331e-12	0.004007	1	0
KCNH3	23416	broad.mit.edu	37	12	49951315	49951315	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:49951315C>T	uc001ruh.1	+	15	3091	c.2831C>T	c.(2830-2832)GCA>GTA	p.A944V	KCNH3_uc010smj.1_Missense_Mutation_p.A884V	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	944	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GACACTGGGGCATCCTCCTAC	0.711			NA											17	39					0	0	0.010504	0	0
FAM186B	84070	broad.mit.edu	37	12	49994704	49994704	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:49994704A>G	uc001ruo.2	-	4	892	c.719T>C	c.(718-720)GTG>GCG	p.V240A	FAM186B_uc010smk.1_Missense_Mutation_p.V150A	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	240						protein complex				ovary(1)	1						GAGGTTCTCCACCACAGTGGC	0.572			NA											4	24					0	0	0.001168	0	0
FMNL3	91010	broad.mit.edu	37	12	50062266	50062266	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:50062266C>T	uc001ruv.1	-	2	432	c.198G>A	c.(196-198)CTG>CTA	p.L66L	FMNL3_uc001ruw.1_Silent_p.L66L	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	66	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						GGTCACAGATCAGATCCCATT	0.552			NA											31	116					0	0	0.003271	0	0
CSRNP2	81566	broad.mit.edu	37	12	51458021	51458021	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:51458021G>A	uc001rxu.1	-	5	1438	c.1140C>T	c.(1138-1140)CTC>CTT	p.L380L		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	380					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGCCTGGATGAGAATGGGGG	0.597			NA											7	90					0	0	0.004482	0	0
SLC4A8	9498	broad.mit.edu	37	12	51863459	51863459	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:51863459C>A	uc001rys.1	+	12	1589	c.1411C>A	c.(1411-1413)CGA>AGA	p.R471R	SLC4A8_uc010sni.1_Silent_p.R418R|SLC4A8_uc001rym.2_Silent_p.R418R|SLC4A8_uc001ryn.2_Silent_p.R418R|SLC4A8_uc001ryo.2_Silent_p.R418R|SLC4A8_uc010snj.1_Silent_p.R498R|SLC4A8_uc001ryq.3_Silent_p.R471R|SLC4A8_uc001ryr.2_Silent_p.R471R|SLC4A8_uc010snk.1_Silent_p.R418R	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	471	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GAGCGACTACCGAGATGCACT	0.542			NA											9	87					0.00829132	0.00888049	0.008291	1	0
KRT85	3891	broad.mit.edu	37	12	52757119	52757119	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:52757119T>C	uc001sag.2	-	5	982	c.862A>G	c.(862-864)ATG>GTG	p.M288V		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	288	Rod.|Coil 2.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		ATGCAGTCCATGTTCAGGTCT	0.577			NA											9	54					0	0	0.004482	0	0
KRT75	9119	broad.mit.edu	37	12	52827880	52827880	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:52827880C>A	uc001saj.2	-	1	231	c.209G>T	c.(208-210)CGG>CTG	p.R70L		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	70	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GATGGAGACCCGCTTGGCACC	0.632			NA											14	79					6.81908e-15	1.08503e-14	0.00245	1	0
KRT74	121391	broad.mit.edu	37	12	52962019	52962019	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:52962019C>T	uc001sap.1	-	7	1337	c.1289G>A	c.(1288-1290)AGC>AAC	p.S430N		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	430	Rod.|Coil 2.					keratin filament	structural molecule activity	p.S430S(1)		ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		CAGTTTCAGGCTCATGAGCTC	0.637			NA											24	84					0	0	0.008361	0	0
KRT2	3849	broad.mit.edu	37	12	53045387	53045387	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:53045387C>T	uc001sat.2	-	1	573	c.540G>A	c.(538-540)GAG>GAA	p.E180E		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	180	Coil 1A.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TTTTGATCTGCTCACGCTCTT	0.522			NA											10	77					0	0	0.008291	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420403	55420403	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:55420403G>A	uc001sgp.3	+	2	558	c.180G>A	c.(178-180)GAG>GAA	p.E60E		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	60	Asp/Glu-rich (acidic).				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						aagaagaagaggaagaagaTG	0.418			NA											3	16					0	0	0.004672	0	0
OR10A7	121364	broad.mit.edu	37	12	55615705	55615705	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:55615705G>T	uc010spf.1	+	1	897	c.897G>T	c.(895-897)GGG>GGT	p.G299G		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						AAGTGAAAGGGGCTGTCAAGA	0.438			NA											11	54					1.5842e-08	2.09458e-08	0.001855	1	0
INHBE	83729	broad.mit.edu	37	12	57850300	57850300	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:57850300A>T	uc001snw.2	+	2	946	c.722A>T	c.(721-723)GAG>GTG	p.E241V		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	241					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						CCCACCTGTGAGCCTGCGACC	0.607	GBM(191;1808 2166 15720 36624 50371)		NA									OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	104					0	0	0.008361	0	0
GEFT	115557	broad.mit.edu	37	12	58008550	58008550	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:58008550C>A	uc001spb.2	+	9	1355	c.895C>A	c.(895-897)CAG>AAG	p.Q299K	GEFT_uc009zpy.2_Missense_Mutation_p.Q338K|GEFT_uc001soz.1_Missense_Mutation_p.Q173K|GEFT_uc001spa.2_Missense_Mutation_p.Q193K|uc001spc.2_Intron|GEFT_uc001spd.2_Missense_Mutation_p.Q4K	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	299	Important for binding to Rho GTPases.|DH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					CATGAAATACCAGCTGCTGCT	0.612			NA											3	19					0.004672	0.00504308	0.004672	1	0
MSRB3	253827	broad.mit.edu	37	12	65672556	65672556	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:65672556C>A	uc001ssn.2	+	1	69	c.8C>A	c.(7-9)CCG>CAG	p.P3Q	MSRB3_uc001ssm.2_5'UTR|MSRB3_uc009zqp.2_5'UTR	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	3					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		TCCATGAGCCCGCGGCGGACC	0.612			NA											5	9					1.6384e-10	2.32177e-10	0.001984	1	0
NAV3	89795	broad.mit.edu	37	12	78516155	78516155	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:78516155G>C	uc001syp.2	+	16	4358	c.4185G>C	c.(4183-4185)GAG>GAC	p.E1395D	NAV3_uc001syo.2_Missense_Mutation_p.E1395D|NAV3_uc010sub.1_Missense_Mutation_p.E895D|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1395	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCACTCACGAGGTCCAGAGCC	0.552			NA								HNSCC(70;0.22)			15	79					0	0	0.004007	0	0
MYF5	4617	broad.mit.edu	37	12	81112163	81112163	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:81112163C>A	uc001szg.2	+	2	663	c.528C>A	c.(526-528)TCC>TCA	p.S176S		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	176					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CTGTCTGGTCCAGAAAGAGCA	0.398			NA											20	166					9.04412e-07	1.11571e-06	0.004656	1	0
TMTC3	160418	broad.mit.edu	37	12	88586476	88586476	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:88586476A>T	uc001tau.2	+	13	2022	c.1802A>T	c.(1801-1803)TAC>TTC	p.Y601F		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	601	TPR 6.					integral to membrane	binding			skin(1)	1						GATCTTTGGTACAACTTGGCA	0.338			NA											12	47					0	0	0.010729	0	0
KERA	11081	broad.mit.edu	37	12	91449195	91449195	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:91449195G>A	uc001tbl.2	-	2	1483	c.864C>T	c.(862-864)CAC>CAT	p.H288H		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	288	LRR 10.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TATGATCAAGGTGAAGGTGCT	0.373			NA											5	68					0	0	0.001984	0	0
UTP20	27340	broad.mit.edu	37	12	101760420	101760420	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:101760420G>T	uc001tia.1	+	47	6366	c.6210G>T	c.(6208-6210)CAG>CAT	p.Q2070H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2070					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GAGGTGGACAGAAAGCTGTTG	0.498			NA											36	126					1.836e-18	3.08106e-18	0.003755	1	0
ACACB	32	broad.mit.edu	37	12	109654631	109654632	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:109654631_109654632GG>TT	uc001tob.2	+	24	3589_3590	c.3470_3471GG>TT	c.(3469-3471)AGG>ATT	p.R1157I	ACACB_uc001toc.2_Missense_Mutation_p.R1157I	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1157					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	ATAAACCTCAGGGAGCAGTTCA	0.554			NA											12	92					0	0	0.004672	0	0
CUX2	23316	broad.mit.edu	37	12	111785442	111785442	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:111785442G>T	uc001tsa.1	+	22	3927	c.3774G>T	c.(3772-3774)CCG>CCT	p.P1258P		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1258						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						ACCCCACCCCGCAGAGCCCTG	0.637			NA											5	59					5.18039e-06	6.22398e-06	0.00308	1	0
PLBD2	196463	broad.mit.edu	37	12	113812710	113812710	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:113812710G>T	uc001tve.2	+	5	792	c.757G>T	c.(757-759)GGC>TGC	p.G253C	PLBD2_uc001tvf.2_Missense_Mutation_p.G253C	NM_173542	NP_775813	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2 isoform 1	253					lipid catabolic process	lysosomal lumen	hydrolase activity				0						GCTGCTCCCTGGCCAGAGTGA	0.582			NA											5	65					8.12818e-05	9.20528e-05	0.001984	1	0
COQ5	84274	broad.mit.edu	37	12	120966774	120966774	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:120966774C>A	uc001tyn.2	-	1	191	c.171G>T	c.(169-171)GAG>GAT	p.E57D	COQ5_uc001tyo.2_5'UTR|COQ5_uc010szj.1_Missense_Mutation_p.E57D	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	57					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGACACAGTCTCAAACCCAA	0.602			NA											30	153					2.51541e-25	4.45572e-25	0.004878	1	0
VPS33A	65082	broad.mit.edu	37	12	122734456	122734456	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:122734456T>C	uc001ucd.2	-	6	850	c.737A>G	c.(736-738)TAT>TGT	p.Y246C	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	246					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		GAGTCCTTCATATGTCAGCTG	0.358			NA											19	103					0	0	0.00278	0	0
GOLGA3	2802	broad.mit.edu	37	12	133384862	133384862	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:133384862C>A	uc001ukz.1	-	5	1352	c.793G>T	c.(793-795)GCT>TCT	p.A265S	GOLGA3_uc001ula.1_Missense_Mutation_p.A265S|GOLGA3_uc001ulb.2_Missense_Mutation_p.A265S	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	265					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GAATCGGGAGCCGGGACATTT	0.527			NA											34	152					1.59361e-14	2.47861e-14	0.006999	1	0
GJB2	2706	broad.mit.edu	37	13	20763189	20763189	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:20763189C>T	uc001umy.2	-	2	747	c.532G>A	c.(532-534)GTG>ATG	p.V178M		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	178	Extracellular (Potential).		V -> A (in DFNB1A).		cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		AAGCAGTCCACAGTGTTGGGA	0.522			NA							Keratitis_Ichthyosis_and_Deafness_syndrome				7	39					0	0	0.00308	0	0
TNFRSF19	55504	broad.mit.edu	37	13	24200868	24200868	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:24200868G>T	uc001uov.1	+	5	446	c.382G>T	c.(382-384)GTC>TTC	p.V128F	TNFRSF19_uc001uot.2_Missense_Mutation_p.V128F|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.V128F	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	128	Extracellular (Potential).|TNFR-Cys 3.				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		GACGAAACTTGTCGGCTTTCA	0.463			NA											6	28					1.12685e-05	1.33642e-05	0.004482	1	0
NBEA	26960	broad.mit.edu	37	13	35619507	35619507	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:35619507C>T	uc001uvb.2	+	5	898	c.692C>T	c.(691-693)ACT>ATT	p.T231I		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	231						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGTCCTGATACTTTTTTCAAT	0.294			NA											2	14					0	0	0.004672	0	0
DCLK1	9201	broad.mit.edu	37	13	36700173	36700173	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:36700173C>T	uc001uvf.2	-	2	335	c.102G>A	c.(100-102)ACG>ACA	p.T34T		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	34					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GGGCGCTGTGCGTCGGGCTCG	0.612			NA											5	89					0	0	0.001168	0	0
ENOX1	55068	broad.mit.edu	37	13	43935525	43935525	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:43935525T>C	uc001uza.3	-	6	572	c.272A>G	c.(271-273)AAC>AGC	p.N91S	ENOX1_uc001uzb.3_Missense_Mutation_p.N91S|ENOX1_uc001uzc.3_Missense_Mutation_p.N91S|ENOX1_uc010tfm.1_5'Flank	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	91	Pro-rich.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TATCATTGGGTTAATGGGGGT	0.443			NA											19	61					0	0	0.008871	0	0
RCBTB1	55213	broad.mit.edu	37	13	50123718	50123718	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:50123718C>A	uc001vde.1	-	9	1182	c.921G>T	c.(919-921)GTG>GTT	p.V307V		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	307	RCC1 6.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		CCCACATGTACACGTGCCCAC	0.577			NA											10	61					4.93089e-13	7.50038e-13	0.00245	1	0
THSD1	55901	broad.mit.edu	37	13	52960220	52960220	+	Missense_Mutation	SNP	G	G	T	rs138873579	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:52960220G>T	uc001vgo.2	-	4	1668	c.1123C>A	c.(1123-1125)CCT>ACT	p.P375T	THSD1_uc001vgp.2_Intron|THSD1_uc010tgz.1_5'UTR|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	375	Extracellular (Potential).|TSP type-1.					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGGCAGACAGGACTGGAGGGG	0.582			NA											17	70					2.35188e-11	3.42054e-11	0.006122	1	0
OLFM4	10562	broad.mit.edu	37	13	53616110	53616110	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:53616110T>A	uc001vhl.2	+	3	423	c.423T>A	c.(421-423)ATT>ATA	p.I141I	OLFM4_uc001vhk.1_Silent_p.I141I	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	141					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CTGTCCGAATTGACATCATGG	0.393			NA											10	68					0	0	0.008291	0	0
OLFM4	10562	broad.mit.edu	37	13	53624337	53624337	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:53624337C>A	uc001vhl.2	+	5	964	c.964C>A	c.(964-966)CGG>AGG	p.R322R	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	322	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TCGAGAGTTGCGGATCACCTA	0.438			NA											10	69					0.000442599	0.000490528	0.006214	1	0
KLHL1	57626	broad.mit.edu	37	13	70535441	70535441	+	Silent	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:70535441T>G	uc001vip.2	-	3	1610	c.816A>C	c.(814-816)ACA>ACC	p.T272T	KLHL1_uc010thm.1_Silent_p.T211T	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	272	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGCCATACCTGTATATGCAA	0.343			NA											9	49					0	0	0.00245	0	0
ABCC4	10257	broad.mit.edu	37	13	95705394	95705394	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:95705394G>A	uc001vmd.3	-	27	3530	c.3411C>T	c.(3409-3411)CCC>CCT	p.P1137P	ABCC4_uc010afj.2_Silent_p.P21P|ABCC4_uc010afk.2_Silent_p.P1090P	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1137	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GCTCATTAAAGGGATCCAGGT	0.378			NA											9	57					0	0	0.013537	0	0
ABCC4	10257	broad.mit.edu	37	13	95840711	95840711	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:95840711C>A	uc001vmd.3	-	10	1468	c.1349G>T	c.(1348-1350)GGG>GTG	p.G450V	ABCC4_uc010afk.2_Missense_Mutation_p.G450V|ABCC4_uc001vme.2_Missense_Mutation_p.G450V|ABCC4_uc010tih.1_Missense_Mutation_p.G375V|ABCC4_uc001vmf.2_Missense_Mutation_p.G407V|ABCC4_uc010afl.1_Missense_Mutation_p.G407V|ABCC4_uc010afm.1_Missense_Mutation_p.G463V	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	450	ATP 1 (Potential).|ABC transporter 1.|Helical; (Potential).				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ACTCACCTTCCCTGCTCCCAC	0.473			NA											16	97					1.28384e-07	1.62737e-07	0.012319	1	0
NALCN	259232	broad.mit.edu	37	13	101759851	101759851	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:101759851C>A	uc001vox.1	-	22	2755	c.2566G>T	c.(2566-2568)GCA>TCA	p.A856S		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	856	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGAAGCGTGCTCGGACCACC	0.498			NA											14	67					1.99824e-07	2.52521e-07	0.00499	1	0
C13orf39	196541	broad.mit.edu	37	13	103346735	103346735	+	Silent	SNP	G	G	T	rs144831458		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr13:103346735G>T	uc001vpj.2	-	1	120	c.114C>A	c.(112-114)ACC>ACA	p.T38T	C13orf39_uc001vpk.2_Silent_p.T38T	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	38							methyltransferase activity				0						GGACTCCCCCGGTGCTGTCTT	0.557			NA											9	43					7.48243e-07	9.27195e-07	0.006214	1	0
OR4K17	390436	broad.mit.edu	37	14	20586231	20586231	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:20586231C>T	uc001vwo.1	+	1	666	c.666C>T	c.(664-666)GAC>GAT	p.D222D		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCTGTATAGACATATATTTTG	0.408			NA											14	102					0	0	0.00245	0	0
FLJ10357	55701	broad.mit.edu	37	14	21550064	21550064	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:21550064G>A	uc001vzp.2	+	14	3066	c.3037G>A	c.(3037-3039)GGA>AGA	p.G1013R	FLJ10357_uc001vzo.1_Missense_Mutation_p.G92R|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.G299R	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	1013					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GGCCCCATGTGGAGAGGACTA	0.687			NA											3	13					0	0	0.004672	0	0
SUPT16H	11198	broad.mit.edu	37	14	21826513	21826513	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:21826513T>C	uc001wao.2	-	20	2714	c.2375A>G	c.(2374-2376)AAG>AGG	p.K792R	SUPT16H_uc001wan.2_5'UTR	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	792					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CAGTTCCTCCTTAGTTAGAGC	0.348			NA											4	40					0	0	0.000602	0	0
LRRC16B	90668	broad.mit.edu	37	14	24527173	24527173	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:24527173G>T	uc001wlj.2	+	16	1379	c.1222G>T	c.(1222-1224)GGT>TGT	p.G408C		NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	408	LRR 6.									ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CCACAGGAAGGGTCGAGAGGC	0.652			NA									OREG0022615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	109					1.12685e-05	1.33642e-05	0.004482	1	0
STRN3	29966	broad.mit.edu	37	14	31376229	31376229	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:31376229G>A	uc001wqu.2	-	14	1958	c.1742C>T	c.(1741-1743)ACT>ATT	p.T581I	STRN3_uc001wqv.2_Missense_Mutation_p.T497I|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	581					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ACCAACTAAAGTGCCAGCTAG	0.343			NA											14	45					0	0	0.004007	0	0
CTAGE5	4253	broad.mit.edu	37	14	39764137	39764137	+	Missense_Mutation	SNP	G	G	T	rs142653668	by1000genomes	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:39764137G>T	uc001wvg.3	+	8	912	c.576G>T	c.(574-576)ATG>ATT	p.M192I	CTAGE5_uc010tqe.1_Missense_Mutation_p.M154I|CTAGE5_uc001wuz.3_Missense_Mutation_p.M180I|CTAGE5_uc001wuy.3_Missense_Mutation_p.M112I|CTAGE5_uc001wvb.3_Missense_Mutation_p.M163I|CTAGE5_uc001wvc.3_Missense_Mutation_p.M137I|CTAGE5_uc001wva.3_Missense_Mutation_p.M163I|CTAGE5_uc001wve.1_Missense_Mutation_p.M168I|CTAGE5_uc001wvh.3_Missense_Mutation_p.M192I|CTAGE5_uc001wvf.3_Missense_Mutation_p.M117I|CTAGE5_uc001wvi.3_Missense_Mutation_p.M197I|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Missense_Mutation_p.M163I	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	192	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		AGGCCAAAATGACCTTCAAGA	0.308			NA											12	56					9.31168e-06	1.1107e-05	0.001855	1	0
LRFN5	145581	broad.mit.edu	37	14	42373362	42373362	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:42373362G>T	uc001wvm.2	+	6	3342	c.2144G>T	c.(2143-2145)AGG>ATG	p.R715M	LRFN5_uc010ana.2_3'UTR	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	715	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		tcatttcAGAGGCTGGAGTTA	0.249			NA								HNSCC(30;0.082)			8	18					3.09899e-07	3.88075e-07	0.004482	1	0
PPIL5	122769	broad.mit.edu	37	14	50081051	50081051	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:50081051G>C	uc001wwn.2	+	4	1406	c.1082G>C	c.(1081-1083)AGA>ACA	p.R361T	SDCCAG1_uc010anj.1_Intron|PPIL5_uc001wwo.2_Missense_Mutation_p.K120N|PPIL5_uc010ank.2_Missense_Mutation_p.R302T|PPIL5_uc001wwp.2_RNA	NM_152329	NP_689542	Q96L50	LLR1_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 5	361											0	all_epithelial(31;0.0021)|Breast(41;0.0124)					GTTTGTGGAAGATTCTGTCTG	0.383			NA											3	48					0	0	0.009096	0	0
NID2	22795	broad.mit.edu	37	14	52508872	52508872	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:52508872C>A	uc001wzo.2	-	7	2010	c.1776G>T	c.(1774-1776)TGG>TGT	p.W592C	NID2_uc010tqs.1_Missense_Mutation_p.W592C|NID2_uc010tqt.1_Missense_Mutation_p.W592C|NID2_uc001wzp.2_Missense_Mutation_p.W592C	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	592	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGCAAAGAGCCAGCCAAACA	0.587			NA											18	103					1.33834e-09	1.82181e-09	0.007413	1	0
KTN1	3895	broad.mit.edu	37	14	56139388	56139388	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:56139388G>T	uc001xcb.2	+	39	3874	c.3572G>T	c.(3571-3573)CGA>CTA	p.R1191L	KTN1_uc001xce.2_Missense_Mutation_p.R1162L|KTN1_uc001xcc.2_Missense_Mutation_p.R1191L|KTN1_uc001xcd.2_Missense_Mutation_p.R1168L|KTN1_uc010trb.1_Missense_Mutation_p.R1191L|KTN1_uc001xcf.1_Missense_Mutation_p.R1168L|KTN1_uc010aoq.2_Missense_Mutation_p.R457L|KTN1_uc010trc.1_Missense_Mutation_p.R196L|KTN1_uc001xcg.2_Missense_Mutation_p.R152L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	1191	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						GAGCTAGAGCGATTAAGAAGC	0.333			NA	T	RET	papillary thryoid								11	21					1.3612e-06	1.67424e-06	0.003163	1	0
RTN1	6252	broad.mit.edu	37	14	60212731	60212731	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:60212731C>A	uc001xen.1	-	2	919	c.710G>T	c.(709-711)CGT>CTT	p.R237L		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	237					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GTCAGGTTCACGGACTCCTTC	0.423			NA											24	114					5.45024e-15	8.70568e-15	0.00333	1	0
KCNH5	27133	broad.mit.edu	37	14	63174819	63174819	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:63174819G>T	uc001xfx.2	-	11	2425	c.2374C>A	c.(2374-2376)CAA>AAA	p.Q792K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	792	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AGACATTTTTGGTCAGCACCG	0.463			NA											4	47					1.23904e-05	1.45697e-05	0.000602	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68251821	68251821	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:68251821T>C	uc001xka.2	-	19	3617	c.3478A>G	c.(3478-3480)AGC>GGC	p.S1160G	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.S1160G	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1160					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCAAGGGTGCTGCAGTAACTG	0.527			NA											19	156					0	0	0.008871	0	0
ADAM20	8748	broad.mit.edu	37	14	70990477	70990477	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:70990477A>T	uc001xme.2	-	2	1393	c.1148T>A	c.(1147-1149)TTG>TAG	p.L383*		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	333	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		AAAAACGACCAACCTGTTGTC	0.423			NA											13	42					0	0	0.001855	0	0
MAP3K9	4293	broad.mit.edu	37	14	71197334	71197334	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:71197334T>A	uc001xmm.2	-	12	3078	c.3078A>T	c.(3076-3078)ACA>ACT	p.T1026T	MAP3K9_uc010ttk.1_Silent_p.T754T|MAP3K9_uc001xmk.2_Silent_p.T759T|MAP3K9_uc001xml.2_Silent_p.T1040T	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	1026	Ser-rich.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGGGCGTCTCTGTGCTGGAGC	0.662	GBM(114;411 1587 13539 28235 50070)		NA											10	46					0	0	0.008291	0	0
PCNX	22990	broad.mit.edu	37	14	71518724	71518724	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:71518724C>G	uc001xmo.2	+	24	5018	c.4572C>G	c.(4570-4572)GAC>GAG	p.D1524E	PCNX_uc010are.1_Missense_Mutation_p.D1413E|PCNX_uc010arf.1_Missense_Mutation_p.D384E	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1524						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGGAGAGAGACTATAAGTGAG	0.363			NA											14	39					0	0	0.004007	0	0
PCNX	22990	broad.mit.edu	37	14	71576284	71576284	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:71576284G>T	uc001xmo.2	+	35	7306	c.6860G>T	c.(6859-6861)AGT>ATT	p.S2287I	PCNX_uc010are.1_Missense_Mutation_p.S2176I|PCNX_uc010arf.1_Missense_Mutation_p.S1075I|PCNX_uc001xmp.2_Missense_Mutation_p.S371I	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2287						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAAGACTGGAGTCCGCAGGAG	0.488			NA											5	46					0.000274275	0.000306434	0.004482	1	0
DPF3	8110	broad.mit.edu	37	14	73181194	73181194	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:73181194C>T	uc001xnc.2	-	6	554	c.541G>A	c.(541-543)GGG>AGG	p.G181R	DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.G181R|DPF3_uc010ttq.1_Missense_Mutation_p.G191R	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	181					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CTCCTGCCCCCTGCAGAGCCG	0.602			NA											19	48					0	0	0.00278	0	0
MLH3	27030	broad.mit.edu	37	14	75514922	75514922	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:75514922T>C	uc001xrd.1	-	2	1653	c.1437A>G	c.(1435-1437)TCA>TCG	p.S479S	MLH3_uc001xre.1_Silent_p.S479S|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	479					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		CTCCAGCTTCTGATGCTACAA	0.378			NA						MMR					7	48					0	0	0.00308	0	0
TMEM63C	57156	broad.mit.edu	37	14	77709290	77709290	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:77709290T>C	uc001xtf.2	+	15	1444	c.1232T>C	c.(1231-1233)ATC>ACC	p.I411T	TMEM63C_uc010asq.1_Missense_Mutation_p.I411T	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	411	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GCCCGCTTTATCGCAATCAAC	0.517			NA											13	54					0	0	0.00245	0	0
SERPINA13	388007	broad.mit.edu	37	14	95110002	95110002	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:95110002G>T	uc001ydt.2	+	3	1039	c.951G>T	c.(949-951)AGG>AGT	p.R317S		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						TCCCCAACAGGGGCAAGATGA	0.602			NA											9	23					0.00621372	0.0066725	0.006214	1	0
RCOR1	23186	broad.mit.edu	37	14	103174805	103174805	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:103174805C>A	uc001ymb.2	+	6	655	c.655C>A	c.(655-657)CCA>ACA	p.P219T		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	219	Interaction with HDAC1.|SANT 1.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						TGTTTAGCTTCCAGATAAATC	0.259			NA											35	119					3.43241e-23	6.00311e-23	0.009718	1	0
AHNAK2	113146	broad.mit.edu	37	14	105417135	105417135	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:105417135C>T	uc010axc.1	-	7	4773	c.4653G>A	c.(4651-4653)GAG>GAA	p.E1551E	AHNAK2_uc001ypx.2_Silent_p.E1451E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1551						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGCCTGGACCTCCAGGTCAG	0.642			NA											38	140					0	0	0.010771	0	0
NIPA1	123606	broad.mit.edu	37	15	23049045	23049045	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:23049045C>A	uc001yvc.2	-	5	799	c.774G>T	c.(772-774)TCG>TCT	p.S258S	NIPA1_uc001yvd.2_Silent_p.S88S|NIPA1_uc001yve.2_Silent_p.S183S	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	258	Cytoplasmic (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		CCCCGAACACCGAGGAGTCGA	0.612			NA											8	33					0.000157383	0.00017703	0.00308	1	0
SNURF	8926	broad.mit.edu	37	15	25207298	25207298	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:25207298G>T	uc001ywu.2	+	2	178	c.52G>T	c.(52-54)GTA>TTA	p.V18L	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_5'UTR|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_RNA|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Missense_Mutation_p.V18L	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	18						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		AGAACAGCACGTACCAGAGGT	0.443			NA											13	68					1.5739e-10	2.24572e-10	0.004007	1	0
UBE3A	7337	broad.mit.edu	37	15	25616900	25616900	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:25616900C>A	uc001zaq.2	-	4	430	c.430G>T	c.(430-432)GAG>TAG	p.E144*	uc001zae.2_Intron|UBE3A_uc001zar.2_Nonsense_Mutation_p.E121*|UBE3A_uc001zas.2_Nonsense_Mutation_p.E141*|UBE3A_uc001zat.2_Nonsense_Mutation_p.E121*	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	144					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GAATAATCCTCTCTTTCTCTA	0.343			NA											4	31					0.00909568	0.00967948	0.009096	1	0
GABRB3	2562	broad.mit.edu	37	15	26806156	26806156	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:26806156C>T	uc001zaz.2	-	8	1145	c.1003G>A	c.(1003-1005)GGC>AGC	p.G335S	GABRB3_uc010uae.1_Missense_Mutation_p.G250S|GABRB3_uc001zba.2_Missense_Mutation_p.G335S|GABRB3_uc001zbb.2_Missense_Mutation_p.G391S	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	335	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTTTGAGGGCCTCTTCCAAAG	0.488			NA											9	49					0	0	0.004482	0	0
GABRB3	2562	broad.mit.edu	37	15	26812798	26812798	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:26812798T>A	uc001zaz.2	-	7	907	c.765A>T	c.(763-765)ATA>ATT	p.I255I	GABRB3_uc010uae.1_Silent_p.I170I|GABRB3_uc001zba.2_Silent_p.I255I|GABRB3_uc001zbb.2_Silent_p.I311I	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	255	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCGTTATCAGTATAGAGGGCA	0.418			NA											10	51					0	0	0.008291	0	0
GABRB3	2562	broad.mit.edu	37	15	26812836	26812836	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:26812836T>C	uc001zaz.2	-	7	869	c.727A>G	c.(727-729)ATT>GTT	p.I243V	GABRB3_uc010uae.1_Missense_Mutation_p.I158V|GABRB3_uc001zba.2_Missense_Mutation_p.I243V|GABRB3_uc001zbb.2_Missense_Mutation_p.I299V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	243	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGTATCCAATGTTCCTCTTC	0.433			NA											12	46					0	0	0.00245	0	0
GABRB3	2562	broad.mit.edu	37	15	27184577	27184577	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:27184577G>T	uc001zbb.2	-	1	110	c.7C>A	c.(7-9)CAG>AAG	p.Q3K	GABRA5_uc001zbd.1_Intron	NM_021912	NP_068712	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	Error:Variant_position_missing_in_P28472_after_alignment					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTCCTGAGCTGCTGCATCTCA	0.597			NA											7	15					0.00307968	0.00334607	0.00308	1	0
RYR3	6263	broad.mit.edu	37	15	33833039	33833039	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:33833039G>C	uc001zhi.2	+	7	664	c.594G>C	c.(592-594)ATG>ATC	p.M198I	RYR3_uc010bar.2_Missense_Mutation_p.M198I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	198	MIR 2.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCCTTTATGCAAACACTCT	0.443			NA											21	64					0	0	0.00333	0	0
RYR3	6263	broad.mit.edu	37	15	33835886	33835886	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:33835886C>A	uc001zhi.2	+	8	780	c.710C>A	c.(709-711)CCA>CAA	p.P237Q	RYR3_uc010bar.2_Missense_Mutation_p.P237Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	237	MIR 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGACGATACCATCTACAGAC	0.403			NA											16	132					1.56452e-12	2.34537e-12	0.007413	1	0
RYR3	6263	broad.mit.edu	37	15	34137231	34137231	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:34137231C>A	uc001zhi.2	+	93	13535	c.13465C>A	c.(13465-13467)CTA>ATA	p.L4489I	RYR3_uc010bar.2_Missense_Mutation_p.L4484I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4489	Helical; Name=M6; (Potential).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATCATCTCTCTAGTCTGTGT	0.517			NA											12	96					1.15088e-07	1.46331e-07	0.004007	1	0
C15orf55	256646	broad.mit.edu	37	15	34647285	34647286	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:34647285_34647286CC>AA	uc001zif.2	+	6	1497_1498	c.1342_1343CC>AA	c.(1342-1344)CCC>AAC	p.P448N	C15orf55_uc010ucc.1_Missense_Mutation_p.P476N|C15orf55_uc010ucd.1_Missense_Mutation_p.P466N	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	448						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		ACAGAGAGATCCCTTGGCCTTA	0.455			NA	T	BRD3|BRD4	lethal midline carcinoma								11	62					0	0	0.004672	0	0
GPR176	11245	broad.mit.edu	37	15	40093898	40093898	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:40093898C>A	uc001zkj.1	-	3	1849	c.983G>T	c.(982-984)CGC>CTC	p.R328L	GPR176_uc010uck.1_Missense_Mutation_p.R268L	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	328	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		CAAGCACTTGCGGACAGATTT	0.552			NA									OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	55					6.40141e-05	7.33993e-05	0.010729	1	0
ZFP106	64397	broad.mit.edu	37	15	42727683	42727683	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:42727683T>A	uc001zpw.2	-	11	5046	c.4711A>T	c.(4711-4713)ACC>TCC	p.T1571S	ZFP106_uc001zpu.2_Missense_Mutation_p.T669S|ZFP106_uc001zpv.2_Missense_Mutation_p.T756S|ZFP106_uc001zpx.2_Missense_Mutation_p.T799S	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	1571	WD 2.					nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		ACTTTGGAGGTATGACCCTCA	0.423			NA											21	70					0	0	0.00278	0	0
DUOX2	50506	broad.mit.edu	37	15	45396433	45396433	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:45396433A>T	uc010bea.2	-	19	2668	c.2465T>A	c.(2464-2466)ATG>AAG	p.M822K	DUOX2_uc001zun.2_Missense_Mutation_p.M822K	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	822	Cytoplasmic (Potential).|EF-hand 1.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTCCACAAACATGTCCTGGGG	0.602			NA											4	30					0	0	0.001984	0	0
DUOX2	50506	broad.mit.edu	37	15	45402891	45402891	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:45402891C>T	uc010bea.2	-	8	1103	c.900G>A	c.(898-900)GAG>GAA	p.E300E	DUOX2_uc001zun.2_Silent_p.E300E	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	300	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TGGGCAGCCACTCATACACAG	0.612			NA											7	65					0	0	0.006214	0	0
VPS13C	54832	broad.mit.edu	37	15	62300902	62300902	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:62300902T>C	uc002agz.2	-	14	1144	c.1070A>G	c.(1069-1071)TAT>TGT	p.Y357C	VPS13C_uc002aha.2_Missense_Mutation_p.Y314C|VPS13C_uc002ahb.1_Missense_Mutation_p.Y357C|VPS13C_uc002ahc.1_Missense_Mutation_p.Y314C	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	357					protein localization					ovary(2)	2						GTATTTCCTATAAGGCGCATT	0.274			NA											10	34					0	0	0.013537	0	0
PAQR5	54852	broad.mit.edu	37	15	69682101	69682101	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:69682101G>T	uc002arz.2	+	6	872	c.494G>T	c.(493-495)GGC>GTC	p.G165V	PAQR5_uc002asa.2_Missense_Mutation_p.G165V	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	165	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						CTCAGCACAGGCCTCTCCTGC	0.582			NA											16	66					1.45105e-14	2.26539e-14	0.006122	1	0
STRA6	64220	broad.mit.edu	37	15	74472534	74472534	+	Missense_Mutation	SNP	C	C	A	rs144308388	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:74472534C>A	uc002axk.2	-	19	2073	c.1891G>T	c.(1891-1893)GGG>TGG	p.G631W	STRA6_uc002axi.2_Missense_Mutation_p.G440W|STRA6_uc010ulh.1_Missense_Mutation_p.G669W|STRA6_uc002axj.2_Missense_Mutation_p.G670W|STRA6_uc010bji.2_Missense_Mutation_p.G631W|STRA6_uc002axl.2_Missense_Mutation_p.G563W|STRA6_uc002axm.2_Missense_Mutation_p.G631W|STRA6_uc002axn.2_Missense_Mutation_p.G622W|STRA6_uc010uli.1_Missense_Mutation_p.G668W	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	631	Cytoplasmic (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						CGGCTGGCCCCGGGCCTAGCT	0.632			NA											39	145					5.34276e-22	9.30492e-22	0.01441	1	0
C15orf26	161502	broad.mit.edu	37	15	81440257	81440257	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:81440257G>T	uc002bgb.2	+	6	722	c.695G>T	c.(694-696)CGG>CTG	p.R232L		NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	232											0						GCAGCCCACCGGCATCTTTTC	0.388			NA											4	62					0.00116845	0.00128127	0.001168	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84488657	84488657	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:84488657G>A	uc002bjz.3	+	6	682	c.458G>A	c.(457-459)CGA>CAA	p.R153Q	ADAMTSL3_uc002bjy.1_Missense_Mutation_p.R153Q|ADAMTSL3_uc010bmt.1_Missense_Mutation_p.R153Q|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.R153Q	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	153						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGCTTCCACGATATAATGAT	0.522			NA											5	40					0	0	0.000602	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651167	84651167	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:84651167C>A	uc002bjz.3	+	21	3011	c.2787C>A	c.(2785-2787)TCC>TCA	p.S929S	ADAMTSL3_uc010bmt.1_Silent_p.S929S|ADAMTSL3_uc010bmu.1_Silent_p.S929S	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	929	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCAACACATCCGTGATTATTA	0.512			NA											19	86					1.33834e-09	1.82181e-09	0.007413	1	0
NTRK3	4916	broad.mit.edu	37	15	88576128	88576128	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:88576128C>A	uc002bme.1	-	13	1707	c.1545G>T	c.(1543-1545)CAG>CAT	p.Q515H	NTRK3_uc002bmh.2_Missense_Mutation_p.Q507H|NTRK3_uc002bmf.1_Missense_Mutation_p.Q515H|NTRK3_uc010upl.1_Missense_Mutation_p.Q417H|NTRK3_uc010bnh.1_Missense_Mutation_p.Q507H|NTRK3_uc002bmg.2_Missense_Mutation_p.Q515H|NTRK3_uc010bni.2_RNA	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	515	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GACGGAAGTACTGGGGGTTCT	0.592			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			6	55					2.7689e-08	3.60914e-08	0.001984	1	0
PRC1	9055	broad.mit.edu	37	15	91510376	91510376	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:91510376G>C	uc002bqm.2	-	15	2005	c.1848C>G	c.(1846-1848)ACC>ACG	p.T616T	PRC1_uc002bqn.2_Silent_p.T602T|PRC1_uc002bqo.2_3'UTR|PRC1_uc010uqs.1_3'UTR	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	616	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					ACTGGATGTTGGTTGAATTGA	0.438			NA											10	80					0	0	0.001855	0	0
VPS33B	26276	broad.mit.edu	37	15	91551121	91551121	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:91551121T>A	uc002bqp.1	-	7	831	c.477A>T	c.(475-477)GAA>GAT	p.E159D	VPS33B_uc002bqq.1_Missense_Mutation_p.E68D|VPS33B_uc010uqu.1_Missense_Mutation_p.E132D	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	159					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CCCTGAAAAATTCTGGTAGTT	0.493			NA											22	106					0	0	0.004656	0	0
SYNM	23336	broad.mit.edu	37	15	99669845	99669845	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:99669845C>A	uc002bup.2	+	6	1400	c.1280C>A	c.(1279-1281)ACT>AAT	p.T427N	SYNM_uc002buo.2_Missense_Mutation_p.T427N|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	427	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						AACGTCAGAACTTTCTCTCCA	0.498	Pancreas(125;1071 1762 21750 40003 40381)		NA											8	53					5.4927e-09	7.39197e-09	0.004482	1	0
NARFL	64428	broad.mit.edu	37	16	787273	787273	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:787273C>A	uc002cjr.2	-	3	231	c.219G>T	c.(217-219)GCG>GCT	p.A73A	NARFL_uc002cjp.2_5'UTR|NARFL_uc002cjq.2_5'UTR|NARFL_uc002cjs.2_5'UTR|NARFL_uc010brc.1_Silent_p.A73A|NARFL_uc010uur.1_Silent_p.A73A	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	73					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				AGCCGCTGCACGCCAGGCAGT	0.617			NA											25	109					7.26314e-15	1.15348e-14	0.007291	1	0
MSLN	10232	broad.mit.edu	37	16	817446	817446	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:817446G>C	uc002cjw.1	+	15	1647	c.1596G>C	c.(1594-1596)ATG>ATC	p.M532I	MSLN_uc002cjt.1_Missense_Mutation_p.M524I|MSLN_uc002cju.1_Missense_Mutation_p.M524I|MSLN_uc010brd.1_Missense_Mutation_p.M523I|MSLN_uc002cjv.1_Missense_Mutation_p.M524I|MSLN_uc002cjx.1_Missense_Mutation_p.M524I|MSLN_uc002cjy.1_Missense_Mutation_p.M189I|MIR662_hsa-mir-662|MI0003670_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	532					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CCACGTTCATGAAGCTGCGGA	0.443			NA											4	141					0	0	0.000602	0	0
PDPK1	5170	broad.mit.edu	37	16	2636732	2636732	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:2636732C>T	uc002cqs.2	+	11	1325	c.1181C>T	c.(1180-1182)TCA>TTA	p.S394L	PDPK1_uc002cqt.2_Missense_Mutation_p.S267L|PDPK1_uc010bsn.2_Missense_Mutation_p.S394L|PDPK1_uc002cqu.2_Missense_Mutation_p.S367L	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	394	Poly-Ser.				actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	TCCTCCTCCTCACACTCCCTG	0.552			NA											4	123					0	0	0.000602	0	0
NUBP1	4682	broad.mit.edu	37	16	10851880	10851880	+	Missense_Mutation	SNP	C	C	T	rs148166867		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:10851880C>T	uc002daa.1	+	7	625	c.602C>T	c.(601-603)CCC>CTC	p.P201L	NUBP1_uc010bum.1_Missense_Mutation_p.P66L|NUBP1_uc002dab.1_Missense_Mutation_p.P190L	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	201					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding	p.P201L(1)		ovary(1)|skin(1)	2						ATCACCACTCCCCAGGTGAGC	0.577			NA											16	64					0	0	0.00499	0	0
ERCC4	2072	broad.mit.edu	37	16	14015915	14015915	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:14015915G>A	uc002dce.2	+	2	244	c.235G>A	c.(235-237)GAA>AAA	p.E79K	ERCC4_uc010bva.2_Missense_Mutation_p.E79K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	79					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						GCTGAAGATAGAAGGAGTTGA	0.358			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	26					0	0	0.001984	0	0
ERCC4	2072	broad.mit.edu	37	16	14029376	14029376	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:14029376T>G	uc002dce.2	+	8	1596	c.1587T>G	c.(1585-1587)ATT>ATG	p.I529M	ERCC4_uc010uyz.1_Missense_Mutation_p.I79M	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	529			I -> T (in XP-F).		double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CGGAAGAAATTAAGCATGAAG	0.458			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				3	87					0	0	0.004672	0	0
NTAN1	123803	broad.mit.edu	37	16	15141948	15141948	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:15141948G>T	uc002ddd.2	-	2	95	c.90C>A	c.(88-90)GCC>GCA	p.A30A	PDXDC1_uc002ddc.2_Intron|NTAN1_uc010uzo.1_Intron	NM_173474	NP_775745	Q96AB6	NTAN1_HUMAN	N-terminal Asn amidase	30						cytoplasm					0						TGAGAAGTCTGGCTCTTTCCT	0.438			NA											23	56					1.22574e-08	1.63104e-08	0.014323	1	0
GPR139	124274	broad.mit.edu	37	16	20043438	20043438	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:20043438G>T	uc002dgu.1	-	2	843	c.681C>A	c.(679-681)ACC>ACA	p.T227T	GPR139_uc010vaw.1_Silent_p.T134T	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	227	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						ACAAGATGGCGGTGGTCTTCC	0.522			NA											10	85					6.72482e-11	9.67861e-11	0.003163	1	0
ACSM1	116285	broad.mit.edu	37	16	20696590	20696590	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:20696590G>A	uc002dhm.1	-	2	396	c.328C>T	c.(328-330)CAG>TAG	p.Q110*	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Nonsense_Mutation_p.Q110*	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	110					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TGGTCTCCCTGTTGTAGGCCA	0.572			NA											12	99					0	0	0.00245	0	0
DNAH3	55567	broad.mit.edu	37	16	21145668	21145668	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:21145668C>T	uc010vbe.1	-	7	994	c.994G>A	c.(994-996)GTC>ATC	p.V332I	DNAH3_uc002die.2_Missense_Mutation_p.V303I	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	332	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTCCTGTAGACACTGTGCCAG	0.542			NA											28	143					0	0	0.012213	0	0
OTOA	146183	broad.mit.edu	37	16	21728345	21728345	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:21728345G>T	uc002djh.2	+	14	1607	c.1606G>T	c.(1606-1608)GAT>TAT	p.D536Y	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.D457Y|OTOA_uc002dji.2_Missense_Mutation_p.D212Y|OTOA_uc010vbk.1_Missense_Mutation_p.D184Y	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	550					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		AGTCCTGAAGGATAAGGAACT	0.438			NA											19	62					1.90627e-21	3.30606e-21	0.012319	1	0
SCNN1B	6338	broad.mit.edu	37	16	23359988	23359988	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:23359988A>T	uc002dln.2	+	2	244	c.68A>T	c.(67-69)AAG>ATG	p.K23M		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	23	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TACACGTACAAGGAGCTGCTG	0.602			NA											10	36					0	0	0.008291	0	0
PRKCB	5579	broad.mit.edu	37	16	24202491	24202491	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:24202491G>T	uc002dmd.2	+	16	2000	c.1803G>T	c.(1801-1803)CGG>CGT	p.R601R	PRKCB_uc002dme.2_Silent_p.R601R	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	601	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CATTTTTCCGGTATATTGATT	0.463			NA											13	63					7.93312e-07	9.80113e-07	0.00245	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29909229	29909229	+	Silent	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:29909229A>T	uc002duq.3	-	2	396	c.156T>A	c.(154-156)GCT>GCA	p.A52A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.A52A|SEZ6L2_uc002dur.3_Silent_p.A52A|SEZ6L2_uc002dus.3_Silent_p.A52A|SEZ6L2_uc010vec.1_Silent_p.A52A|SEZ6L2_uc010ved.1_Intron|ASPHD1_uc002dut.2_5'Flank|ASPHD1_uc002duu.3_5'Flank|ASPHD1_uc010bzi.2_5'Flank	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	52	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GAAGCAGTTCAGCCAGGGCCT	0.637			NA											15	48					0	0	0.004007	0	0
SEPT1	1731	broad.mit.edu	37	16	30390500	30390500	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:30390500C>T	uc002dxy.2	-	10	952	c.765G>A	c.(763-765)GAG>GAA	p.E255E	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Silent_p.E80E	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	255					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			GATGTGGGTTCTCCACTGGAG	0.617			NA											4	72					0	0	0.009096	0	0
ITGAM	3684	broad.mit.edu	37	16	31282309	31282309	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:31282309G>T	uc002ebq.2	+	6	560	c.462G>T	c.(460-462)TTG>TTT	p.L154F	ITGAM_uc002ebr.2_Missense_Mutation_p.L154F	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	154	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TTGCCTTCTTGATTGATGGCT	0.433			NA											36	205					2.00842e-17	3.32331e-17	0.010771	1	0
ITGAX	3687	broad.mit.edu	37	16	31388167	31388167	+	Silent	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:31388167A>T	uc002ebu.1	+	21	2623	c.2556A>T	c.(2554-2556)CCA>CCT	p.P852P	ITGAX_uc002ebt.2_Silent_p.P852P	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	852	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACAGCGCCCCAGTTGGGAGCC	0.532			NA											14	60					0	0	0.003163	0	0
ZNF267	10308	broad.mit.edu	37	16	31885291	31885291	+	Splice_Site	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:31885291G>A	uc002ecs.3	+	1	212	c.3_splice	c.e1+1	p.M1_splice		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						CTGGGAAATGGTGAGTGTGCG	0.647			NA											14	86					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	16	33784689	33784689	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:33784689G>C	uc010vgb.1	+	2	98	c.78G>C	c.(76-78)CCG>CCC	p.P26P						RecName: Full=Transporter;												NA						ACTACGAGCCGCTGGTCTACA	0.478			NA											5	112					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	16	33784709	33784709	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:33784709A>T	uc010vgb.1	+	2	118	c.98A>T	c.(97-99)AAC>ATC	p.N33I						RecName: Full=Transporter;												NA						AACAACACCAACGTGTACCCG	0.547			NA											9	96					0	0	0.010729	0	0
GPT2	84706	broad.mit.edu	37	16	46958355	46958355	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:46958355C>A	uc002eel.2	+	10	1361	c.1267C>A	c.(1267-1269)CTG>ATG	p.L423M	GPT2_uc002eem.2_Missense_Mutation_p.L323M|GPT2_uc002een.2_Missense_Mutation_p.L66M	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	423					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GACGGAAGACCTGTTTAACCA	0.517			NA											15	62					8.60227e-14	1.32061e-13	0.004007	1	0
NETO2	81831	broad.mit.edu	37	16	47117479	47117479	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:47117479C>A	uc002eer.1	-	9	1616	c.1231G>T	c.(1231-1233)GAC>TAC	p.D411Y	NETO2_uc002eeq.1_Missense_Mutation_p.D146Y|NETO2_uc010vgf.1_Missense_Mutation_p.D268Y	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	411	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TCTGCCAGGTCTGCAGAAATC	0.512			NA								HNSCC(25;0.065)			9	50					0.00448238	0.00485104	0.004482	1	0
ZNF423	23090	broad.mit.edu	37	16	49764838	49764838	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:49764838C>A	uc002efs.2	-	4	419	c.121G>T	c.(121-123)GCG>TCG	p.A41S		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	41					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TCTTCCAGCGCACGGCTGGTT	0.502			NA											28	213					1.30897e-18	2.20556e-18	0.009535	1	0
CYLD	1540	broad.mit.edu	37	16	50818357	50818357	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:50818357G>C	uc002egp.1	+	12	2359	c.1944G>C	c.(1942-1944)CTG>CTC	p.L648L	CYLD_uc002ego.2_Silent_p.L645L|CYLD_uc010cbs.1_Silent_p.L645L|CYLD_uc002egq.1_Silent_p.L645L|CYLD_uc002egr.1_Silent_p.L645L|CYLD_uc002egs.1_Silent_p.L645L	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	648					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TTAATCCTCTGAGAATGTAAG	0.333			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				7	41					0	0	0.006214	0	0
NLRC5	84166	broad.mit.edu	37	16	57073725	57073725	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:57073725C>G	uc002ekk.1	+	16	3059	c.2834C>G	c.(2833-2835)GCC>GGC	p.A945G	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.A694G|NLRC5_uc002ekl.2_Missense_Mutation_p.A750G|NLRC5_uc002ekm.2_Missense_Mutation_p.A750G|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_5'Flank|NLRC5_uc002ekp.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	945	LRR 7.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TTCATGTTTGCCCAGGAGCCA	0.517			NA											25	129					0	0	0.007291	0	0
POLR2C	5432	broad.mit.edu	37	16	57505025	57505025	+	Silent	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:57505025A>T	uc002elt.1	+	9	908	c.822A>T	c.(820-822)ATA>ATT	p.I274I		NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	274					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						TGCTAACCATAAATTAACTGC	0.453			NA											15	56					0	0	0.006122	0	0
KCTD19	146212	broad.mit.edu	37	16	67327654	67327654	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:67327654G>T	uc002esu.2	-	12	2062	c.2011C>A	c.(2011-2013)CCC>ACC	p.P671T	KCTD19_uc002est.2_Missense_Mutation_p.P443T|KCTD19_uc010vjj.1_Missense_Mutation_p.P414T	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	671						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTTCCCAAGGGGAGCTGCAGG	0.617			NA											22	84					9.95505e-16	1.60872e-15	0.014323	1	0
TSNAXIP1	55815	broad.mit.edu	37	16	67854847	67854847	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:67854847C>A	uc002euj.2	+	3	485	c.91C>A	c.(91-93)CGA>AGA	p.R31R	TSNAXIP1_uc010cep.2_5'UTR|TSNAXIP1_uc010vjz.1_Intron|TSNAXIP1_uc002euf.3_Intron|TSNAXIP1_uc010vka.1_Silent_p.R85R|TSNAXIP1_uc010vkb.1_Intron|TSNAXIP1_uc002eug.3_Intron|TSNAXIP1_uc002euh.3_Intron|TSNAXIP1_uc002eui.3_Intron|TSNAXIP1_uc002euk.2_5'Flank	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	31					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CTACCGGAAGCGAGTAGGGTA	0.592			NA											48	165					1.89013e-27	3.36248e-27	0.01441	1	0
Unknown	0	broad.mit.edu	37	16	74425572	74425572	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:74425572C>T	uc010vmt.1	+	6	744	c.743C>T	c.(742-744)TCT>TTT	p.S248F						RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;												NA						CTTCCACCCTCTCCTCTTCCA	0.498			NA											5	300					0	0	0.004482	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76592451	76592451	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:76592451G>T	uc002feu.1	+	26	4183	c.3798G>T	c.(3796-3798)CAG>CAT	p.Q1266H	CNTNAP4_uc002fev.1_Missense_Mutation_p.Q1130H|CNTNAP4_uc010chb.1_Missense_Mutation_p.Q1193H|CNTNAP4_uc002fex.1_Missense_Mutation_p.Q1269H	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1266	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GCATTTATCAGCAGAAAAGGT	0.363			NA											10	39					0.00010058	0.000113598	0.013537	1	0
NUDT7	283927	broad.mit.edu	37	16	77775776	77775776	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:77775776C>T	uc010chd.2	+	4	715	c.646C>T	c.(646-648)CTT>TTT	p.L216F	NUDT7_uc010vnj.1_Missense_Mutation_p.L163F	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	216					nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						TCAATTTAATCTTAATGATGT	0.378			NA											3	30					0	0	0.009096	0	0
PKD1L2	114780	broad.mit.edu	37	16	81232518	81232518	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:81232518C>A	uc002fgh.1	-	7	1292	c.1292G>T	c.(1291-1293)GGC>GTC	p.G431V	PKD1L2_uc002fgj.2_Missense_Mutation_p.G431V	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	431	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGTGGTGTTGCCGGTGGCTTG	0.567			NA											34	158					4.14481e-20	7.05554e-20	0.00623	1	0
CDH13	1012	broad.mit.edu	37	16	83711848	83711848	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:83711848G>T	uc002fgx.2	+	10	1440	c.1320G>T	c.(1318-1320)CTG>CTT	p.L440L	CDH13_uc010vns.1_Silent_p.L487L|CDH13_uc010vnt.1_Silent_p.L186L|CDH13_uc010vnu.1_Silent_p.L401L	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	440	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCCACACCCTGCTGATCAAAG	0.537			NA											11	40					2.27111e-07	2.85698e-07	0.013537	1	0
IRF8	3394	broad.mit.edu	37	16	85946800	85946800	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:85946800A>T	uc002fjh.2	+	5	568	c.511A>T	c.(511-513)AGT>TGT	p.S171C	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	171					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				GGCCTGTCGGAGTCAGCTCCT	0.612			NA											19	104					0	0	0.012319	0	0
ZNF232	7775	broad.mit.edu	37	17	5009656	5009656	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:5009656C>T	uc002gas.2	-	5	1471	c.717G>A	c.(715-717)CTG>CTA	p.L239L	ZNF232_uc002gar.1_Silent_p.L257L|ZNF232_uc002gat.2_Silent_p.L266L	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	239					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCTCTGCTGCAGTTCTAAGG	0.488			NA											16	42					0	0	0.008871	0	0
TP53	7157	broad.mit.edu	37	17	7578431	7578431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:7578431G>A	uc002gim.2	-	5	693	c.499C>T	c.(499-501)CAG>TAG	p.Q167*	TP53_uc002gig.1_Nonsense_Mutation_p.Q167*|TP53_uc002gih.2_Nonsense_Mutation_p.Q167*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q35*|TP53_uc010cng.1_Nonsense_Mutation_p.Q35*|TP53_uc002gii.1_Nonsense_Mutation_p.Q35*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q167*|TP53_uc010cni.1_Nonsense_Mutation_p.Q167*|TP53_uc002gij.2_Nonsense_Mutation_p.Q167*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q74*|TP53_uc002gio.2_Nonsense_Mutation_p.Q35*|TP53_uc010vug.1_Nonsense_Mutation_p.Q128*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	167	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		QH -> HD (in a sporadic cancer; somatic mutation).|Q -> K (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|QH -> YL (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q167*(19)|p.Q167fs*14(8)|p.0?(7)|p.Q167R(4)|p.Q167L(3)|p.Q167H(3)|p.Q167Q(3)|p.Q167fs*13(3)|p.Q167fs*3(3)|p.K164fs*3(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.Q167K(1)|p.Y163fs*1(1)|p.P151_V173del23(1)|p.Q167E(1)|p.Q167del(1)|p.Q167fs*12(1)|p.S149fs*72(1)|p.Q167_H168>HD(1)|p.Q167_H168>YL(1)|p.Q167fs*4(1)|p.Q165_M169delQSQHM(1)|p.A159_Q167delAMAIYKQSQ(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATGTGCTGTGACTGCTTG	0.642	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	47					0	0	0.004007	0	0
MAP2K4	6416	broad.mit.edu	37	17	12016657	12016657	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:12016657G>T	uc002gnj.2	+	7	862	c.793G>T	c.(793-795)GGC>TGC	p.G265C	MAP2K4_uc002gnk.2_Missense_Mutation_p.G276C|MAP2K4_uc010vvi.1_Missense_Mutation_p.G147C|MAP2K4_uc010vvj.1_Missense_Mutation_p.G137C	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	265	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		AAGAGATGCTGGCTGTAGGCC	0.463			NA	D|Mis|N		pancreatic|breast|colorectal								11	49					1.61879e-10	2.29791e-10	0.013537	1	0
KSR1	8844	broad.mit.edu	37	17	25938579	25938579	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:25938579C>T	uc010crg.2	+	19	2517	c.2072C>T	c.(2071-2073)GCA>GTA	p.A691V	KSR1_uc002gzm.2_Missense_Mutation_p.A470V|KSR1_uc002gzn.2_Missense_Mutation_p.A42V	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	826	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.I691I(1)		lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GCTGCAGAGGCATCCATCTGG	0.567	Esophageal Squamous(88;1120 1336 6324 10502 16832)		NA											11	36					0	0	0.00245	0	0
RAB34	83871	broad.mit.edu	37	17	27044007	27044007	+	Silent	SNP	C	C	G	rs146560008		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:27044007C>G	uc002hce.2	-	2	684	c.60G>C	c.(58-60)CTG>CTC	p.L20L	RAB34_uc002hcg.2_Silent_p.L20L|RAB34_uc002hcf.2_Silent_p.L20L|RAB34_uc010was.1_Silent_p.L77L|RAB34_uc010wat.1_Silent_p.L77L|RAB34_uc002hch.2_Silent_p.L20L|RAB34_uc010wau.1_Silent_p.L20L|RAB34_uc010wav.1_Silent_p.L77L|RPL23A_uc002hci.2_5'Flank	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	20					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					CCTCCTTCCTCAGGCACTTAG	0.647	Pancreas(175;216 2049 29940 32498 41589)		NA											14	27					0	0	0.00245	0	0
TIAF1	9220	broad.mit.edu	37	17	27401169	27401169	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:27401169C>A	uc002hdv.1	-	1	1459	c.49G>T	c.(49-51)GCT>TCT	p.A17S	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	17					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCGTCTCCAGCTGCACAGAGA	0.597			NA											9	62					0.000442599	0.000490528	0.006214	1	0
NF1	4763	broad.mit.edu	37	17	29663414	29663414	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:29663414G>T	uc002hgg.2	+	41	6403	c.6070G>T	c.(6070-6072)GGA>TGA	p.G2024*	NF1_uc002hgh.2_Nonsense_Mutation_p.G2003*|NF1_uc010cso.2_Nonsense_Mutation_p.G212*|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2024					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGGTGGCTTGGGATCAATAAA	0.383			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			10	69					1.61879e-10	2.29791e-10	0.013537	1	0
TMEM132E	124842	broad.mit.edu	37	17	32953535	32953535	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:32953535T>A	uc002hif.2	+	2	785	c.457T>A	c.(457-459)TGG>AGG	p.W153R		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	153	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CGGCCGGGACTGGGACGACTT	0.697			NA											12	21					0	0	0.004007	0	0
C17orf78	284099	broad.mit.edu	37	17	35733069	35733069	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:35733069C>A	uc002hns.2	+	1	85	c.35C>A	c.(34-36)GCA>GAA	p.A12E	ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc002hnq.2_Intron|C17orf78_uc010cva.1_Missense_Mutation_p.A12E	NM_173625	NP_775896	Q8N4C9	CQ078_HUMAN	hypothetical protein LOC284099	12						integral to membrane					0		Breast(25;0.00295)|Ovarian(249;0.15)				CTAATCATTGCATCCTATGAT	0.458			NA											7	47					0.00448238	0.00485104	0.004482	1	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305839	39305839	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:39305839A>T	uc002hwb.2	-	1	216	c.181T>A	c.(181-183)TGC>AGC	p.C61S		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	61	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|9.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ctggagatgcagcagctaggg	0.274			NA											3	61					0	0	0.000602	0	0
SC65	10609	broad.mit.edu	37	17	39967431	39967432	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:39967431_39967432CC>AA	uc002hxt.2	-	2	851_852	c.567_568GG>TT	c.(565-570)CTGGAC>CTTTAC	p.D190Y	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.D281Y	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	190					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		TCGGCGACGTCCAGCATCCCCT	0.639			NA											12	316					0	0	0.004672	0	0
AOC3	8639	broad.mit.edu	37	17	41004815	41004815	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:41004815A>G	uc002ibv.2	+	1	1615	c.1455A>G	c.(1453-1455)ATA>ATG	p.I485M		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	485	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GTGGGGCCATAGAAATACGAT	0.547	NSCLC(3;192 220 10664 11501 16477)		NA											16	91					0	0	0.008871	0	0
FZD2	2535	broad.mit.edu	37	17	42635099	42635099	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:42635099C>A	uc002igx.1	+	1	175	c.43C>A	c.(43-45)CTG>ATG	p.L15M		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	15					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		gctgccgctgctgctgctgcC	0.453			NA											4	20					0.00909568	0.00967948	0.009096	1	0
NPEPPS	9520	broad.mit.edu	37	17	45669330	45669330	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:45669330G>T	uc002ilr.3	+	11	1492	c.1269G>T	c.(1267-1269)GTG>GTT	p.V423V	NPEPPS_uc010wkt.1_Silent_p.V419V|NPEPPS_uc010wku.1_Silent_p.V387V|NPEPPS_uc010wkv.1_5'UTR	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	423					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						AGGTCAGTGTGGGCCATCCAT	0.423			NA											3	63					0.00909568	0.00967948	0.009096	1	0
TBX21	30009	broad.mit.edu	37	17	45811281	45811281	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:45811281A>T	uc002ilv.1	+	1	672	c.461A>T	c.(460-462)CAG>CTG	p.Q154L		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	154	T-box.				lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						AATCAGCACCAGACAGAGATG	0.617			NA											7	46					0	0	0.004482	0	0
MRPL10	124995	broad.mit.edu	37	17	45904472	45904472	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:45904472C>A	uc002ilz.2	-	3	347	c.321G>T	c.(319-321)GAG>GAT	p.E107D	MRPL10_uc010wky.1_Missense_Mutation_p.E68D|MRPL10_uc002ily.2_Missense_Mutation_p.E117D	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	107					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GAAGCTTGTCCTCTGCACTCA	0.557			NA											18	104					3.62473e-10	5.07585e-10	0.012319	1	0
BZRAP1	9256	broad.mit.edu	37	17	56384267	56384267	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:56384267G>A	uc002ivx.3	-	25	5917	c.5046C>T	c.(5044-5046)TAC>TAT	p.Y1682Y	BZRAP1_uc002ivv.2_5'Flank|BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Silent_p.Y1622Y|BZRAP1_uc010wnt.1_Silent_p.Y1682Y	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1682	SH3 2.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGCAGGGAATGTAGCCTGTCC	0.587			NA											24	82					0	0	0.004656	0	0
TEX14	56155	broad.mit.edu	37	17	56663276	56663276	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:56663276C>G	uc010dcz.1	-	18	3092	c.2974G>C	c.(2974-2976)GAG>CAG	p.E992Q	TEX14_uc002iwr.1_Missense_Mutation_p.E986Q|TEX14_uc002iws.1_Missense_Mutation_p.E986Q|TEX14_uc010dda.1_Missense_Mutation_p.E766Q	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	992						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTATGATACTCAATAACTCGC	0.527			NA											4	113					0	0	0.001168	0	0
TRIM37	4591	broad.mit.edu	37	17	57105837	57105837	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:57105837C>A	uc002iwy.3	-	19	2640	c.2196G>T	c.(2194-2196)TTG>TTT	p.L732F	TRIM37_uc002iwz.3_Missense_Mutation_p.L732F|TRIM37_uc002ixa.3_Missense_Mutation_p.L610F|TRIM37_uc010woc.1_Missense_Mutation_p.L698F	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	732						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CCAAATCCTGCAATCTGCCAG	0.453			NA							Mulibrey_Nanism				12	46					1.52009e-12	2.28289e-12	0.003163	1	0
BCAS3	54828	broad.mit.edu	37	17	59067346	59067346	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:59067346C>T	uc002iyv.3	+	15	1345	c.1236C>T	c.(1234-1236)TGC>TGT	p.C412C	BCAS3_uc010wow.1_Silent_p.C199C|BCAS3_uc002iyu.3_Silent_p.C412C|BCAS3_uc002iyw.3_Silent_p.C408C|BCAS3_uc002iyx.1_Silent_p.C227C|BCAS3_uc002iyy.3_Silent_p.C183C|BCAS3_uc002iyz.3_5'UTR|BCAS3_uc002iza.3_5'UTR	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	412	WD 3.					nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGGACATCTGCTTCAGCCATG	0.433			NA											12	83					0	0	0.003163	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128429	68128429	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:68128429C>T	uc002jin.2	+	5	687	c.201C>T	c.(199-201)GAC>GAT	p.D67D	KCNJ16_uc002jio.2_Silent_p.D67D|KCNJ16_uc002jip.2_Silent_p.D67D|KCNJ16_uc002jiq.2_Silent_p.D99D	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	67	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CTCTTGTGGACACCAAGTGGC	0.418			NA											21	90					0	0	0.00333	0	0
DNAI2	64446	broad.mit.edu	37	17	72297275	72297275	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:72297275G>T	uc002jkf.2	+	8	1054	c.955G>T	c.(955-957)GGG>TGG	p.G319W	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	319					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AAATGCCTTGGGGGCCATCTC	0.542			NA							Kartagener_syndrome				47	176					1.54886e-18	2.60447e-18	0.01441	1	0
TMEM104	54868	broad.mit.edu	37	17	72832430	72832430	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:72832430C>T	uc002jls.3	+	10	1257	c.1095C>T	c.(1093-1095)ATC>ATT	p.I365I	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.I365I	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	365	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)					TCTTCACCATCAGCACCAACT	0.627			NA											24	279					0	0	0.010818	0	0
OTOP3	347741	broad.mit.edu	37	17	72943385	72943385	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:72943385G>C	uc010wrr.1	+	6	1435	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	OTOP3_uc010wrq.1_Missense_Mutation_p.E461Q	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	479						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCACTCTGGGAGACAGTTCC	0.667			NA											3	17					0	0	0.004672	0	0
MIF4GD	57409	broad.mit.edu	37	17	73263692	73263692	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:73263692A>T	uc002jnr.2	-	5	497	c.368T>A	c.(367-369)ATG>AAG	p.M123K	MIF4GD_uc002jno.2_Missense_Mutation_p.M164K|MIF4GD_uc002jnp.2_Missense_Mutation_p.M157K|MIF4GD_uc002jnq.2_Missense_Mutation_p.M164K			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	123	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CACCAGGGCCATCATGGGCAT	0.617			NA											20	87					0	0	0.00278	0	0
WBP2	23558	broad.mit.edu	37	17	73847686	73847686	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:73847686C>A	uc002jps.2	-	2	254	c.131G>T	c.(130-132)GGG>GTG	p.G44V	WBP2_uc002jpr.2_Missense_Mutation_p.G10V|WBP2_uc010wsl.1_Missense_Mutation_p.G10V|WBP2_uc002jpt.2_Missense_Mutation_p.G44V|WBP2_uc002jpu.1_RNA|WBP2_uc010wsm.1_Missense_Mutation_p.G44V|WBP2_uc010wsn.1_Missense_Mutation_p.G44V	NM_012478	NP_036610	Q969T9	WBP2_HUMAN	WW domain binding protein 2	44	GRAM.						protein binding				0			all cancers(21;2.61e-06)|Epithelial(20;2.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTTCTTGGTCCCTTTGAAGGC	0.488			NA											33	146					1.59361e-14	2.47861e-14	0.006999	1	0
QRICH2	84074	broad.mit.edu	37	17	74287225	74287225	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:74287225C>G	uc002jrd.1	-	4	3265	c.3085G>C	c.(3085-3087)GAG>CAG	p.E1029Q	QRICH2_uc010wsz.1_Missense_Mutation_p.E955Q|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1029							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TGAAATGTCTCCACTGCCGTG	0.527			NA											7	130					0	0	0.006214	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79943454	79943454	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr17:79943454G>C	uc002kcx.2	+	4	442	c.345G>C	c.(343-345)TGG>TGC	p.W115C	ASPSCR1_uc002kcw.1_Missense_Mutation_p.W115C|ASPSCR1_uc002kcy.2_Missense_Mutation_p.W115C|ASPSCR1_uc002kcz.2_Missense_Mutation_p.W115C|ASPSCR1_uc002kda.2_Missense_Mutation_p.W38C|ASPSCR1_uc002kdb.1_Missense_Mutation_p.W38C	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	115							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AGACCCTCTGGGAGCTTCTCA	0.557			NA	T	TFE3	alveolar soft part sarcoma								12	43					0	0	0.001855	0	0
ESCO1	114799	broad.mit.edu	37	18	19147950	19147950	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:19147950T>A	uc002kth.1	-	5	2570	c.1636A>T	c.(1636-1638)AAA>TAA	p.K546*	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	546					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						CCTGGAAATTTATTCTCTCCT	0.348			NA											24	39					0	0	0.003954	0	0
ESCO1	114799	broad.mit.edu	37	18	19153945	19153945	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:19153945T>C	uc002kth.1	-	4	1794	c.860A>G	c.(859-861)CAA>CGA	p.Q287R	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	287					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						ATTATCACTTTGTTCAGGCAC	0.428			NA											19	37					0	0	0.006122	0	0
DSC2	1824	broad.mit.edu	37	18	28654794	28654794	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:28654794T>A	uc002kwl.3	-	12	2197	c.1743A>T	c.(1741-1743)ACA>ACT	p.T581T	DSC2_uc002kwk.3_Silent_p.T581T	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	581	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AGATGATCACTGTCTTTTTAG	0.438			NA											10	20					0	0	0.010729	0	0
RIT2	6014	broad.mit.edu	37	18	40503687	40503687	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:40503687C>T	uc002lav.2	-	4	449	c.276G>A	c.(274-276)GGG>GGA	p.G92G	RIT2_uc010dnf.2_Silent_p.G92G	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	92					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						TGAAGCCTTCCCCACCTCGCA	0.433			NA											49	167					0	0	0.01441	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560930	44560930	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:44560930G>T	uc002lcr.1	-	1	1059	c.706C>A	c.(706-708)CCC>ACC	p.P236T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	236				P -> L (in Ref. 1; BAA90665).	regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GCACACAAGGGGCGTTTTTCC	0.617			NA											7	20					5.18039e-06	6.22398e-06	0.00308	1	0
CCDC11	220136	broad.mit.edu	37	18	47769339	47769339	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:47769339C>G	uc002lee.2	-	6	1235	c.1144G>C	c.(1144-1146)GAA>CAA	p.E382Q		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	382	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCCTCCTTTTCAAGTCTCAGC	0.403			NA											4	158					0	0	0.001168	0	0
SMAD4	4089	broad.mit.edu	37	18	48575104	48575104	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:48575104A>T	uc010xdp.1	+	3	836	c.298A>T	c.(298-300)AGG>TGG	p.R100W	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	100	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)|p.R100T(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CCGTCTCTGGAGGTGGCCTGA	0.308			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				20	49					0	0	0.003954	0	0
HMSD	284293	broad.mit.edu	37	18	61620700	61620700	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:61620700C>T	uc010dqj.2	+	2	160	c.11C>T	c.(10-12)TCA>TTA	p.S4L		NM_001123366	NP_001116838	A8MTL9	HMSD_HUMAN	histocompatibility (minor) serpin domain	4						extracellular region	serine-type endopeptidase inhibitor activity				0						ATGAGCATATCATCAGCCTTG	0.418			NA											5	22					0	0	0.001168	0	0
CTDP1	9150	broad.mit.edu	37	18	77474845	77474845	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr18:77474845G>C	uc002lnh.1	+	8	1532	c.1385G>C	c.(1384-1386)AGT>ACT	p.S462T	CTDP1_uc002lni.1_Missense_Mutation_p.S462T|CTDP1_uc010drd.1_Missense_Mutation_p.S462T	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	462	Ser-rich.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GAGAGCAGCAGTGAGTCCGAG	0.677			NA											3	5					0	0	0.004672	0	0
CCDC94	55702	broad.mit.edu	37	19	4249230	4249230	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:4249230C>G	uc002lzv.3	+	2	63	c.30C>G	c.(28-30)TAC>TAG	p.Y10*		NM_018074	NP_060544	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	10											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		TGCAGAAATACTACCCGCCGG	0.542			NA											11	25					0	0	0.001855	0	0
CD70	970	broad.mit.edu	37	19	6590996	6590996	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:6590996C>A	uc002mfi.2	-	1	168	c.18G>T	c.(16-18)TCG>TCT	p.S6S	CD70_uc010xjf.1_Silent_p.S6S	NM_001252	NP_001243	P32970	CD70_HUMAN	tumor necrosis factor ligand superfamily, member	6	Cytoplasmic (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding				0						CCGAGCAGCCCGAACCCTCCT	0.692	Pancreas(183;2617 2876 10173 34193)		NA											15	33					4.14922e-12	6.15331e-12	0.004007	1	0
XAB2	56949	broad.mit.edu	37	19	7688058	7688058	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:7688058C>T	uc002mgx.2	-	9	1263	c.1237G>A	c.(1237-1239)GAT>AAT	p.D413N		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	413					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						GTGCTCACATCGTCCAGCTGT	0.338			NA						Direct_reversal_of_damage|NER					6	73					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9003616	9003616	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:9003616G>A	uc002mkp.2	-	49	40228	c.40024C>T	c.(40024-40026)CGC>TGC	p.R13342C	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.R159C|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13344	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCCAGGGCGACGCATGTCC	0.552			NA											11	249					0	0	0.010729	0	0
MUC16	94025	broad.mit.edu	37	19	9077685	9077685	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:9077685C>A	uc002mkp.2	-	3	9965	c.9761G>T	c.(9760-9762)AGT>ATT	p.S3254I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3255	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGCTGCCACTTCCTAGGGC	0.522			NA											23	128					3.73988e-18	6.26336e-18	0.00632	1	0
CDC37	11140	broad.mit.edu	37	19	10505933	10505933	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:10505933T>C	uc002mof.1	-	4	690	c.574A>G	c.(574-576)ATT>GTT	p.I192V	CDC37_uc002moe.1_Missense_Mutation_p.I147V|CDC37_uc010dxf.1_Missense_Mutation_p.I29V|CDC37_uc002mog.1_Missense_Mutation_p.I192V|CDC37_uc002moh.2_Missense_Mutation_p.I192V	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	192					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		ATGCACCAAATGACCAGGTAA	0.582			NA											34	175					0	0	0.00874	0	0
ZNF20	7568	broad.mit.edu	37	19	12243512	12243512	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:12243512C>A	uc002mtf.1	-	4	1632	c.1489G>T	c.(1489-1491)GAA>TAA	p.E497*	ZNF20_uc002mte.1_Nonsense_Mutation_p.E462*|ZNF20_uc002mtg.1_Nonsense_Mutation_p.E497*	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	497	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGTCCTTTCATGATATCGA	0.413			NA											31	119					2.61193e-14	4.03972e-14	0.009535	1	0
OR7C2	26658	broad.mit.edu	37	19	15052757	15052757	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:15052757G>T	uc010xoc.1	+	1	457	c.457G>T	c.(457-459)GTC>TTC	p.V153F		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					GTGCATCAGTGTCATGGGTTC	0.517			NA											23	150					1.55469e-16	2.52714e-16	0.00333	1	0
MAP1S	55201	broad.mit.edu	37	19	17844205	17844205	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:17844205G>T	uc002nhe.1	+	6	3001	c.2992G>T	c.(2992-2994)GCC>TCC	p.A998S	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Missense_Mutation_p.A246S|MAP1S_uc010xpv.1_Missense_Mutation_p.A972S	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	998	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						CGCGCTACTGGCCAGCAAGCA	0.627			NA											3	16					1.23904e-05	1.45697e-05	0.000602	1	0
NCAN	1463	broad.mit.edu	37	19	19339151	19339151	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:19339151C>T	uc002nlz.2	+	8	2821	c.2722C>T	c.(2722-2724)CAG>TAG	p.Q908*	NCAN_uc010ecc.1_Nonsense_Mutation_p.Q472*	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	908					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGTGGAGACCCAGGGAACATC	0.622			NA											13	76					0	0	0.004007	0	0
ZNF100	163227	broad.mit.edu	37	19	21926894	21926894	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:21926894C>A	uc002nqi.2	-	4	446	c.247G>T	c.(247-249)GAC>TAC	p.D83Y	ZNF100_uc002nqh.2_Missense_Mutation_p.D19Y	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	83	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGATCAGGTCTGGCTTAGTG	0.408			NA											14	109					1.99824e-07	2.52521e-07	0.00499	1	0
ZNF98	148198	broad.mit.edu	37	19	22574916	22574916	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:22574916C>A	uc002nqt.2	-	4	1243	c.1121G>T	c.(1120-1122)GGA>GTA	p.G374V		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGGTTTCTCTCCAGAATGAAT	0.373			NA											4	21					1.06961e-07	1.37474e-07	0.00308	1	0
ZNF99	7652	broad.mit.edu	37	19	22940385	22940385	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:22940385G>A	uc010xrh.1	-	5	2053	c.2053C>T	c.(2053-2055)CTT>TTT	p.L685F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTTTTCTAAGGGCTGAGAAA	0.353			NA											7	42					0	0	0.00308	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768982	31768983	+	Silent	DNP	GG	GG	AT			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:31768982_31768983GG>AT	uc002nsy.3	-	2	1781_1782	c.1716_1717CC>AT	c.(1714-1719)CCCCTG>CCATTG	p.572_573PL>PL		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	572_573					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ATGGGTTTCAGGGGCGTGCTCT	0.589			NA											20	96					0	0	0.004672	0	0
CHST8	64377	broad.mit.edu	37	19	34263536	34263536	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:34263536G>A	uc002nus.3	+	5	1348	c.843G>A	c.(841-843)CCG>CCA	p.P281P	CHST8_uc002nut.3_Silent_p.P281P|CHST8_uc002nuu.2_Silent_p.P281P	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	281	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					ACTATCACCCGGTCTTCGGCA	0.632			NA											22	83					0	0	0.012319	0	0
ZBTB32	27033	broad.mit.edu	37	19	36205655	36205655	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:36205655C>G	uc002oay.2	+	2	337	c.127C>G	c.(127-129)CAC>GAC	p.H43D	ZBTB32_uc002oaz.2_RNA	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	43	BTB.				DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTTCCCCGCCCACAGCCTGGT	0.637			NA											9	38					0	0	0.008291	0	0
C19orf55	148137	broad.mit.edu	37	19	36259083	36259083	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:36259083G>T	uc002obq.1	+	10	1320	c.1247G>T	c.(1246-1248)CGA>CTA	p.R416L		NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	Error:Variant_position_missing_in_Q2NL68_after_alignment										ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTTCCAGGACGATCCCGTGCT	0.632			NA											9	31					0.00185496	0.00203139	0.001855	1	0
NPHS1	4868	broad.mit.edu	37	19	36340164	36340164	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:36340164G>T	uc002oby.2	-	7	814	c.814C>A	c.(814-816)CCC>ACC	p.P272T		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	272	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTGGCTAAGGGATTACCCCCT	0.677			NA											7	51					0.00198382	0.00215825	0.001984	1	0
ZNF382	84911	broad.mit.edu	37	19	37117284	37117284	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:37117284G>C	uc002oek.2	+	5	598	c.485G>C	c.(484-486)GGT>GCT	p.G162A	ZNF382_uc010efa.2_Missense_Mutation_p.G113A|ZNF382_uc010efb.2_Missense_Mutation_p.G161A|ZNF382_uc002oel.2_Missense_Mutation_p.G161A	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	162	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAGAAGTTTGGTGACAGTACT	0.343			NA											25	102					0	0	0.005443	0	0
RYR1	6261	broad.mit.edu	37	19	39003104	39003104	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:39003104G>T	uc002oit.2	+	63	9583	c.9453G>T	c.(9451-9453)CAG>CAT	p.Q3151H	RYR1_uc002oiu.2_Missense_Mutation_p.Q3151H|RYR1_uc002oiv.1_Missense_Mutation_p.Q71H|RYR1_uc010xuf.1_Missense_Mutation_p.Q71H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3151					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCAGCACCAGTTCGGAGATG	0.642			NA											19	78					7.45023e-12	1.09314e-11	0.010504	1	0
LGALS4	3960	broad.mit.edu	37	19	39303124	39303124	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:39303124G>C	uc002ojg.2	-	2	295	c.81C>G	c.(79-81)CTC>CTG	p.L27L	LGALS4_uc010xuj.1_Silent_p.L27L	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	27	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			TTCCCACGTTGAGCCCGCCCG	0.612			NA											7	87					0	0	0.006214	0	0
SIRT2	22933	broad.mit.edu	37	19	39369807	39369807	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:39369807C>G	uc002ojt.1	-	16	1358	c.1158G>C	c.(1156-1158)GAG>GAC	p.E386D	RINL_uc002ojq.2_5'Flank|RINL_uc010xuo.1_5'Flank|SIRT2_uc010egh.1_3'UTR|SIRT2_uc010egi.1_Missense_Mutation_p.E349D|SIRT2_uc002ojs.1_Missense_Mutation_p.E366D|SIRT2_uc002oju.1_Missense_Mutation_p.E349D|SIRT2_uc010egj.1_Missense_Mutation_p.E349D|SIRT2_uc002ojv.1_Missense_Mutation_p.E384D	NM_012237	NP_036369	Q8IXJ6	SIRT2_HUMAN	sirtuin 2 isoform 1	386					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			ACTGGGGTTTCTCCCTCTCTG	0.657			NA											3	72					0	0	0.009096	0	0
IL28B	282617	broad.mit.edu	37	19	39735580	39735580	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:39735580C>G	uc010xut.1	-	1	32	c.28G>C	c.(28-30)GTG>CTG	p.V10L	IL28B_uc010xuu.1_Missense_Mutation_p.V10L	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	10					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GCCATCAGCACCAGCACTGGC	0.637			NA											18	67					0	0	0.012319	0	0
SPTBN4	57731	broad.mit.edu	37	19	40978613	40978613	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:40978613G>A	uc002ony.2	+	2	171	c.85G>A	c.(85-87)GAT>AAT	p.D29N	SPTBN4_uc002onx.2_Missense_Mutation_p.D29N|SPTBN4_uc002onz.2_Missense_Mutation_p.D29N	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	29	Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAGAGTCCGGATCGGGGCTG	0.657			NA											3	22					0	0	0.004672	0	0
CD79A	973	broad.mit.edu	37	19	42383065	42383065	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:42383065G>A	uc002orv.2	+	2	270	c.85G>A	c.(85-87)GGG>AGG	p.G29R	CD79A_uc002oru.2_Missense_Mutation_p.G29R	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor	29					B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3						CACAGGCCCTGGGTGCCAGGC	0.627			NA	O|S		DLBCL								5	31					0	0	0.001168	0	0
ZNF526	116115	broad.mit.edu	37	19	42728695	42728695	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:42728695C>T	uc002osz.1	+	3	296	c.140C>T	c.(139-141)GCC>GTC	p.A47V		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GAGGCCCTTGCCTCATCCCTC	0.537			NA											34	106					0	0	0.004289	0	0
CADM4	199731	broad.mit.edu	37	19	44129230	44129230	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:44129230C>A	uc002oxc.1	-	7	977	c.928G>T	c.(928-930)GAC>TAC	p.D310Y		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	310	Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				CTGCTCTCACCGTAGACCACA	0.502			NA											9	27					3.86212e-05	4.46541e-05	0.008291	1	0
ZNF229	7772	broad.mit.edu	37	19	44933973	44933973	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:44933973C>A	uc002oze.1	-	6	1417	c.983G>T	c.(982-984)CGG>CTG	p.R328L	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Missense_Mutation_p.R322L	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TCTGACGCCCCGACCACGCTC	0.498			NA											7	32					8.12818e-05	9.20528e-05	0.001984	1	0
BCAM	4059	broad.mit.edu	37	19	45322685	45322685	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:45322685G>T	uc002ozu.2	+	12	1600	c.1556G>T	c.(1555-1557)GGC>GTC	p.G519V	BCAM_uc002ozt.1_Missense_Mutation_p.G519V	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	519	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				AGCCGCGATGGCATCTCCTGT	0.642			NA											16	68					4.96729e-08	6.41415e-08	0.008871	1	0
PPFIA3	8541	broad.mit.edu	37	19	49643283	49643283	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:49643283G>A	uc002pmr.2	+	18	2638	c.2306G>A	c.(2305-2307)CGT>CAT	p.R769H	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.R637H|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	769						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TCCATAGGCCGTCTCTTTGGC	0.488			NA											19	76					0	0	0.014323	0	0
KLK3	354	broad.mit.edu	37	19	51361545	51361545	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:51361545G>T	uc002pts.1	+	3	508	c.467G>T	c.(466-468)GGC>GTC	p.G156V	KLK3_uc010ycj.1_Intron|KLK3_uc002ptr.1_Missense_Mutation_p.G113V|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	156	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		TACGCCTCAGGCTGGGGCAGC	0.423	Colon(185;1767 2023 13025 30120 37630)		NA											8	30					2.17888e-05	2.54407e-05	0.006214	1	0
ZNF534	147658	broad.mit.edu	37	19	52941259	52941259	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:52941259G>A	uc002pzk.2	+	4	646	c.585G>A	c.(583-585)AGG>AGA	p.R195R	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Silent_p.R182R	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACACATTAGGGAAAAGCCTT	0.328			NA											5	61					0	0	0.001984	0	0
ZNF578	147660	broad.mit.edu	37	19	53013861	53013861	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:53013861C>A	uc002pzp.3	+	6	471	c.227C>A	c.(226-228)TCA>TAA	p.S76*		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:Variant_position_missing_in_Q96N58_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GAGGTCTTGTCAACAGGGCAA	0.383			NA											39	159					2.51966e-14	3.91161e-14	0.01441	1	0
ZNF320	162967	broad.mit.edu	37	19	53384015	53384015	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:53384015T>G	uc002qag.2	-	4	1555	c.1364A>C	c.(1363-1365)CAC>CCC	p.H455P	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.H401P|ZNF320_uc002qai.2_Missense_Mutation_p.H455P	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	455	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		CCTAATAAGGTGTGAAGGTGA	0.418			NA											11	36					0	0	0.010729	0	0
VN1R2	317701	broad.mit.edu	37	19	53762294	53762294	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:53762294G>A	uc002qbi.2	+	1	750	c.666G>A	c.(664-666)CTG>CTA	p.L222L		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	222	Helical; Name=4; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		TCCACATGCTGGTAAATGCCA	0.448			NA											4	32					0	0	0.001168	0	0
VN1R4	317703	broad.mit.edu	37	19	53770608	53770608	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:53770608A>G	uc010ydu.1	-	1	311	c.311T>C	c.(310-312)TTC>TCC	p.F104S		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	104	Helical; Name=3; (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		GATCACCTGGAAGACACTCAA	0.493			NA								HNSCC(26;0.072)			3	36					0	0	0.009096	0	0
NLRP7	199713	broad.mit.edu	37	19	55451341	55451341	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:55451341G>T	uc002qih.3	-	4	922	c.846C>A	c.(844-846)CTC>CTA	p.L282L	NLRP7_uc002qig.3_Silent_p.L282L|NLRP7_uc002qii.3_Silent_p.L282L|NLRP7_uc010esk.2_Silent_p.L282L|NLRP7_uc010esl.2_Silent_p.L310L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	282	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AACTCCCCAGGAGGACGGGCA	0.632			NA											7	54					1.76689e-08	2.31765e-08	0.006214	1	0
UBE2S	27338	broad.mit.edu	37	19	55918297	55918297	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:55918297T>A	uc002qkx.1	-	2	405	c.37A>T	c.(37-39)ATC>TTC	p.I13F	uc002qky.2_5'Flank	NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	13					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		ACCAGGCGGATGATGTGCGGG	0.602			NA											12	75					0	0	0.00245	0	0
NLRP8	126205	broad.mit.edu	37	19	56467274	56467274	+	Missense_Mutation	SNP	G	G	T	rs75924528	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:56467274G>T	uc002qmh.2	+	3	1921	c.1850G>T	c.(1849-1851)CGG>CTG	p.R617L	NLRP8_uc010etg.2_Missense_Mutation_p.R617L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	617						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CATGAAATCCGGGAGGAAGCC	0.448			NA											12	66					4.36969e-10	6.07798e-10	0.001855	1	0
ZNF71	58491	broad.mit.edu	37	19	57133482	57133482	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:57133482G>T	uc002qnm.3	+	3	1065	c.827G>T	c.(826-828)GGG>GTG	p.G276V		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	276	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CCCGAGTGCGGGCGAGCCTTC	0.662			NA											10	74					4.68919e-08	6.06449e-08	0.008291	1	0
ZNF749	388567	broad.mit.edu	37	19	57955885	57955885	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:57955885C>G	uc002qoq.2	+	3	1623	c.1369C>G	c.(1369-1371)CAG>GAG	p.Q457E	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		AGTTCAGCACCAGAAAATCCA	0.423			NA											3	64					0	0	0.009096	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190216	58190216	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:58190216G>A	uc002qpu.2	+	5	1942	c.1245G>A	c.(1243-1245)ATG>ATA	p.M415I		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	415	C2H2-type 4.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCGCCATATGAGGACTCATG	0.453			NA											9	73					0	0	0.006214	0	0
ZNF551	90233	broad.mit.edu	37	19	58198259	58198259	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:58198259C>T	uc002qpw.3	+	3	791	c.568C>T	c.(568-570)CAC>TAC	p.H190Y	ZNF551_uc002qpv.3_Missense_Mutation_p.H133Y|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGAGGAGCCACACAGTAGCAG	0.483			NA											30	94					0	0	0.00632	0	0
ZNF154	7710	broad.mit.edu	37	19	58213959	58213959	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:58213959T>A	uc010euf.2	-	3	598	c.358A>T	c.(358-360)AGC>TGC	p.S120C	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	120						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCACCGTCGCTTTTGCTATTT	0.502			NA											30	106					0	0	0.00632	0	0
C19orf18	147685	broad.mit.edu	37	19	58485792	58485792	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:58485792C>A	uc002qqv.2	-	1	113	c.9G>T	c.(7-9)AAG>AAT	p.K3N		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	3						integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CACTCTGAACCTTGTCCATCA	0.383			NA											8	51					0.00621372	0.0066725	0.006214	1	0
NT5C1B	93034	broad.mit.edu	37	2	18766133	18766133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:18766133G>A	uc002rcz.2	-	5	654	c.550C>T	c.(550-552)CAG>TAG	p.Q184*	NT5C1B_uc002rcy.2_Nonsense_Mutation_p.Q184*|NT5C1B_uc010exr.2_Nonsense_Mutation_p.Q126*|NT5C1B_uc010yju.1_Nonsense_Mutation_p.Q124*|NT5C1B_uc002rda.2_Nonsense_Mutation_p.Q124*|NT5C1B_uc010yjv.1_Nonsense_Mutation_p.Q201*|NT5C1B_uc010yjw.1_Nonsense_Mutation_p.Q167*|NT5C1B_uc010exs.2_Nonsense_Mutation_p.Q186*|NT5C1B_uc002rdb.1_5'UTR	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	184	Pro-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CGGGGCAGCTGGGGCGACGCG	0.721			NA											6	17					0	0	0.004482	0	0
APOB	338	broad.mit.edu	37	2	21233305	21233305	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:21233305G>T	uc002red.2	-	26	6563	c.6435C>A	c.(6433-6435)CTC>CTA	p.L2145L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2145	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACTTTTTTGTGAGAGCAGTCA	0.358			NA											6	12					8.12818e-05	9.20528e-05	0.001984	1	0
PFN4	375189	broad.mit.edu	37	2	24342519	24342519	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:24342519G>C	uc002rfa.1	-	4	465	c.289C>G	c.(289-291)CTG>GTG	p.L97V	LOC375190_uc002rew.2_Intron	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	97					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAAGATACAGATGGGTCTTC	0.468			NA											3	59					0	0	0.009096	0	0
NCOA1	8648	broad.mit.edu	37	2	24981020	24981020	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:24981020G>C	uc002rfk.2	+	19	4318	c.4060G>C	c.(4060-4062)GAG>CAG	p.E1354Q	NCOA1_uc010eye.2_Missense_Mutation_p.E1354Q|NCOA1_uc002rfi.2_Missense_Mutation_p.E1203Q|NCOA1_uc002rfj.2_Missense_Mutation_p.E1354Q|NCOA1_uc002rfl.2_Missense_Mutation_p.E1354Q|NCOA1_uc010eyf.2_Missense_Mutation_p.E247Q	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1354									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGTGCCCTGAGCAGGTAAG	0.473			NA	T	PAX3	alveolar rhadomyosarcoma								4	110					0	0	0.000602	0	0
OTOF	9381	broad.mit.edu	37	2	26706361	26706361	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:26706361G>T	uc002rhk.2	-	13	1488	c.1361C>A	c.(1360-1362)CCC>CAC	p.P454H		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	454	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCACGTAGGGGTCCACGAG	0.542	GBM(102;732 1451 20652 24062 31372)		NA											15	55					1.15088e-07	1.46331e-07	0.004007	1	0
PREB	10113	broad.mit.edu	37	2	27354694	27354694	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:27354694G>A	uc002rix.1	-	8	1258	c.1005C>T	c.(1003-1005)CTC>CTT	p.L335L	PREB_uc002riy.1_Silent_p.L263L|PREB_uc002riz.1_RNA|PREB_uc002rja.1_Silent_p.L277L	NM_013388	NP_037520	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding protein	335	Cytoplasmic (Potential).|WD 3.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACGTAGTAGAGGCACTGTG	0.562			NA											6	149					0	0	0.001984	0	0
CCDC121	79635	broad.mit.edu	37	2	27850292	27850292	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:27850292C>G	uc002rle.2	-	2	556	c.375G>C	c.(373-375)CAG>CAC	p.Q125H	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.Q289H|CCDC121_uc002rld.2_Missense_Mutation_p.Q287H|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	125	Potential.										0	Acute lymphoblastic leukemia(172;0.155)					TTGTCTCCTCCTGTAATGTCT	0.438			NA											7	138					0	0	0.00308	0	0
LTBP1	4052	broad.mit.edu	37	2	33413810	33413810	+	Silent	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:33413810C>G	uc002ros.2	+	7	1593	c.1593C>G	c.(1591-1593)ACC>ACG	p.T531T	LTBP1_uc002rot.2_Silent_p.T205T|LTBP1_uc002rou.2_Silent_p.T205T|LTBP1_uc002rov.2_Silent_p.T205T|LTBP1_uc010ymz.1_Silent_p.T205T|LTBP1_uc010yna.1_Silent_p.T205T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	531					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCCAGAAGACCCAGACCATAC	0.527			NA											30	85					0	0	0.010818	0	0
LTBP1	4052	broad.mit.edu	37	2	33500974	33500974	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:33500974G>T	uc002ros.2	+	18	2979	c.2979G>T	c.(2977-2979)CAG>CAT	p.Q993H	LTBP1_uc002rot.2_Missense_Mutation_p.Q667H|LTBP1_uc002rou.2_Missense_Mutation_p.Q666H|LTBP1_uc002rov.2_Missense_Mutation_p.Q613H|LTBP1_uc010ymz.1_Missense_Mutation_p.Q666H|LTBP1_uc010yna.1_Missense_Mutation_p.Q613H	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	992	EGF-like 6; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GCATGACTCAGAGAGGCCGTT	0.577			NA											13	85					1.05317e-09	1.44549e-09	0.00245	1	0
EML4	27436	broad.mit.edu	37	2	42556062	42556062	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:42556062A>G	uc002rsi.2	+	22	2640	c.2378A>G	c.(2377-2379)AAT>AGT	p.N793S	EML4_uc010fap.2_Missense_Mutation_p.N735S|EML4_uc002rsj.2_Missense_Mutation_p.N482S|EML4_uc010faq.2_Missense_Mutation_p.N138S|EML4_uc010ynv.1_Missense_Mutation_p.N57S	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	793					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						ACAGATATCAATGCACTGGTG	0.418			NA	T	ALK	NSCLC								13	61					0	0	0.006122	0	0
BCL11A	53335	broad.mit.edu	37	2	60687738	60687738	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:60687738T>C	uc002sae.1	-	4	2537	c.2309A>G	c.(2308-2310)TAT>TGT	p.Y770C	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.Y736C|BCL11A_uc002sad.1_Missense_Mutation_p.Y618C|BCL11A_uc002saf.1_Missense_Mutation_p.Y736C	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	770	C2H2-type 5.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CTCGCATTTATAAGGCCTTTC	0.522			NA	T	IGH@	B-CLL								14	68					0	0	0.003163	0	0
XPO1	7514	broad.mit.edu	37	2	61712950	61712950	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:61712950G>C	uc002sbj.2	-	20	3189	c.2461C>G	c.(2461-2463)CAA>GAA	p.Q821E	XPO1_uc010fcl.2_Missense_Mutation_p.Q817E|XPO1_uc010ypn.1_Missense_Mutation_p.Q817E|XPO1_uc002sbk.2_Missense_Mutation_p.Q382E|XPO1_uc002sbg.2_Missense_Mutation_p.Q18E|XPO1_uc002sbh.2_Missense_Mutation_p.Q468E	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	821					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TCAAATATTTGAGGTATTTCA	0.358			NA											9	81					0	0	0.006214	0	0
PROKR1	10887	broad.mit.edu	37	2	68873314	68873314	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:68873314G>A	uc010yqj.1	+	1	361	c.361G>A	c.(361-363)GAC>AAC	p.D121N	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	121	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						CTTTGAGATGGACTACTATGT	0.577			NA											32	180					0	0	0.00623	0	0
FAM136A	84908	broad.mit.edu	37	2	70524579	70524579	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:70524579T>A	uc002sgq.3	-	3	336	c.259A>T	c.(259-261)AAC>TAC	p.N87Y	FAM136A_uc010fdp.2_RNA	NM_032822	NP_116211	Q96C01	F136A_HUMAN	hypothetical protein LOC84908	87						mitochondrion	protein binding				0						GCTTTGTCGTTGCAATGCATG	0.428			NA											20	80					0	0	0.003954	0	0
DYSF	8291	broad.mit.edu	37	2	71780294	71780294	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:71780294C>G	uc002sie.2	+	20	2282	c.1906C>G	c.(1906-1908)CAG>GAG	p.Q636E	DYSF_uc010feg.2_Missense_Mutation_p.Q667E|DYSF_uc010feh.2_Missense_Mutation_p.Q622E|DYSF_uc002sig.3_Missense_Mutation_p.Q622E|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.Q636E|DYSF_uc010fef.2_Missense_Mutation_p.Q653E|DYSF_uc010fei.2_Missense_Mutation_p.Q653E|DYSF_uc010fek.2_Missense_Mutation_p.Q654E|DYSF_uc010fej.2_Missense_Mutation_p.Q623E|DYSF_uc010fel.2_Missense_Mutation_p.Q623E|DYSF_uc010feo.2_Missense_Mutation_p.Q668E|DYSF_uc010fem.2_Missense_Mutation_p.Q637E|DYSF_uc010fen.2_Missense_Mutation_p.Q654E|DYSF_uc002sif.2_Missense_Mutation_p.Q637E	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	636	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTCCACCACTCAGTACAGCCG	0.592			NA											6	132					0	0	0.00308	0	0
SMYD5	10322	broad.mit.edu	37	2	73441427	73441427	+	Missense_Mutation	SNP	C	C	G	rs114057959	by1000genomes	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:73441427C>G	uc002siw.2	+	1	62	c.33C>G	c.(31-33)TTC>TTG	p.F11L	SMYD5_uc010yre.1_5'UTR	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	11							metal ion binding				0						TGTTCTCCTTCTGCGTGGGCG	0.697			NA											7	193					0	0	0.00245	0	0
DQX1	165545	broad.mit.edu	37	2	74745595	74745595	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:74745595C>T	uc010yrw.1	-	12	2297	c.2132G>A	c.(2131-2133)AGA>AAA	p.R711K	DQX1_uc002smc.2_Missense_Mutation_p.R272K	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	711						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						ACAGGGATCTCTGAACTCCTG	0.522			NA											16	65					0	0	0.00499	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746718	77746718	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:77746718C>G	uc002snr.2	-	3	692	c.277G>C	c.(277-279)GAC>CAC	p.D93H	LRRTM4_uc002snq.2_Missense_Mutation_p.D93H|LRRTM4_uc002sns.2_Missense_Mutation_p.D93H|LRRTM4_uc002snt.2_Missense_Mutation_p.D94H	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	93	LRR 2.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TAATTATGGTCAAGATAAAGC	0.388			NA											9	47					0	0	0.008291	0	0
REG3A	5068	broad.mit.edu	37	2	79385829	79385829	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:79385829C>A	uc002sod.1	-	2	398	c.143G>T	c.(142-144)GGC>GTC	p.G48V	REG3A_uc002soe.1_Missense_Mutation_p.G48V|REG3A_uc002sof.1_Missense_Mutation_p.G48V	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	48	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GCAGTGGGAGCCATAGGCCTT	0.552			NA											13	43					0.000308642	0.000343903	0.003163	1	0
SLC9A2	6549	broad.mit.edu	37	2	103299909	103299909	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:103299909G>T	uc002tca.2	+	4	1336	c.1194G>T	c.(1192-1194)CTG>CTT	p.L398L		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	398	Helical; Name=K/M9; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GCTTCACCCTGGCCTTCTGCC	0.502			NA											10	35					1.58986e-06	1.94395e-06	0.008291	1	0
MFSD9	84804	broad.mit.edu	37	2	103335097	103335097	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:103335097C>T	uc002tcb.2	-	6	1275	c.1207G>A	c.(1207-1209)GGC>AGC	p.G403S	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	403					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						TGGGCCCCGCCCACAGTCAGC	0.657			NA											7	39					0	0	0.004482	0	0
GPR45	11250	broad.mit.edu	37	2	105858977	105858977	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:105858977C>T	uc002tco.1	+	1	778	c.662C>T	c.(661-663)ACG>ATG	p.T221M		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	221	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						ATCCTCAACACGGTCCGCAAG	0.677			NA											7	32					0	0	0.001984	0	0
GPR45	11250	broad.mit.edu	37	2	105858998	105858998	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:105858998G>T	uc002tco.1	+	1	799	c.683G>T	c.(682-684)CGC>CTC	p.R228L		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	228	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AACGCCGTGCGCGTGCACAAC	0.652			NA											8	57					5.18039e-06	6.22398e-06	0.00308	1	0
SLC5A7	60482	broad.mit.edu	37	2	108622574	108622574	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:108622574C>A	uc002tdv.2	+	7	1087	c.811C>A	c.(811-813)CAA>AAA	p.Q271K	SLC5A7_uc010ywm.1_Missense_Mutation_p.Q24K|SLC5A7_uc010fjj.2_Missense_Mutation_p.Q271K|SLC5A7_uc010ywn.1_Missense_Mutation_p.Q158K	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	271	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CACCTATGCTCAAGTGCTGTC	0.537			NA											23	78					7.92952e-12	1.15732e-11	0.003954	1	0
RANBP2	5903	broad.mit.edu	37	2	109352623	109352623	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:109352623G>T	uc002tem.3	+	6	826	c.700G>T	c.(700-702)GAC>TAC	p.D234Y		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	234					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AACCAATACAGACTTACTGCT	0.388			NA											18	78					4.35082e-09	5.87431e-09	0.010504	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125555898	125555898	+	Splice_Site	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:125555898G>T	uc002tno.2	+	19	3578	c.3214_splice	c.e19+1	p.G1072_splice	CNTNAP5_uc010flu.2_Splice_Site_p.G1073_splice	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCAAGAATGGTGAGTGTGAT	0.502			NA											4	22					0.00909568	0.00967948	0.009096	1	0
SMPD4	55627	broad.mit.edu	37	2	130931107	130931107	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:130931107C>A	uc002tqq.1	-	4	886	c.366G>T	c.(364-366)GTG>GTT	p.V122V	SMPD4_uc002tqp.1_5'Flank|SMPD4_uc010yzy.1_Intron|SMPD4_uc010yzz.1_Intron|SMPD4_uc002tqr.1_Silent_p.V122V|SMPD4_uc002tqs.1_Intron|SMPD4_uc002tqt.1_5'UTR|SMPD4_uc010zaa.1_Missense_Mutation_p.D35Y|SMPD4_uc010zab.1_Intron|SMPD4_uc010zac.1_Intron|SMPD4_uc010zad.1_Intron	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	83					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GAAATTCCATCACGATGCTGT	0.527			NA											9	42					1.76689e-08	2.31765e-08	0.006214	1	0
LOC401010	401010	broad.mit.edu	37	2	132201296	132201296	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:132201296G>C	uc002tst.2	-	1	1172	c.706C>G	c.(706-708)CTG>GTG	p.L236V		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						GCATTGTGCAGGTGTATGGCG	0.607			NA											13	43					0	0	0.00245	0	0
MCM6	4175	broad.mit.edu	37	2	136630325	136630325	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:136630325C>T	uc002tuw.2	-	2	272	c.196G>A	c.(196-198)GTG>ATG	p.V66M		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	66					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCAGGTCCACAAAACTCACA	0.403	Ovarian(196;141 2104 8848 24991 25939)		NA											16	71					0	0	0.003163	0	0
NEB	4703	broad.mit.edu	37	2	152507090	152507090	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:152507090C>G	uc010fnx.2	-	53	7416	c.7225G>C	c.(7225-7227)GAG>CAG	p.E2409Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2409	Nebulin 64.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAACTGACCTCACTTTGCAGT	0.338			NA											5	92					0	0	0.001984	0	0
TBR1	10716	broad.mit.edu	37	2	162273430	162273430	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:162273430C>T	uc002ubw.1	+	1	811	c.509C>T	c.(508-510)CCC>CTC	p.P170L	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CAGGGATACCCCACGGCCGGC	0.647			NA											30	129					0	0	0.013726	0	0
ITGA6	3655	broad.mit.edu	37	2	173333936	173333936	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:173333936G>T	uc002uhp.1	+	4	674	c.471G>T	c.(469-471)CTG>CTT	p.L157L	ITGA6_uc010fqk.1_Silent_p.L43L|ITGA6_uc010zdy.1_Silent_p.L43L|ITGA6_uc002uho.1_Silent_p.L157L|ITGA6_uc010fql.2_5'Flank	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	157	Extracellular (Potential).|FG-GAP 2.				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			GTTATGTCCTGAGTCAGAATC	0.478			NA											36	98					4.14481e-20	7.05554e-20	0.00623	1	0
ITGA6	3655	broad.mit.edu	37	2	173340351	173340351	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:173340351G>A	uc002uhp.1	+	8	1410	c.1207G>A	c.(1207-1209)GAC>AAC	p.D403N	ITGA6_uc010zdy.1_Missense_Mutation_p.D284N|ITGA6_uc002uho.1_Missense_Mutation_p.D403N|ITGA6_uc010fqm.1_Missense_Mutation_p.D49N	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	442	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TCCGTATGATGACTTGGGAAA	0.348			NA											4	135					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179404688	179404688	+	Missense_Mutation	SNP	G	G	T	rs74984787		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:179404688G>T	uc010zfg.1	-	301	90624	c.90400C>A	c.(90400-90402)CCT>ACT	p.P30134T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P23829T|TTN_uc010zfi.1_Missense_Mutation_p.P23762T|TTN_uc010zfj.1_Missense_Mutation_p.P23637T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31061							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATAATCAGGATATTCTGGA	0.373			NA											6	36					0.00116845	0.00128127	0.001168	1	0
TTN	7273	broad.mit.edu	37	2	179458737	179458737	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:179458737C>A	uc010zfg.1	-	246	50903	c.50679G>T	c.(50677-50679)GTG>GTT	p.V16893V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V10588V|TTN_uc010zfi.1_Silent_p.V10521V|TTN_uc010zfj.1_Silent_p.V10396V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17820							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTGTTCTCCACAACCACAC	0.398			NA											30	87					2.08457e-15	3.36208e-15	0.010818	1	0
TTN	7273	broad.mit.edu	37	2	179575482	179575482	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:179575482G>T	uc010zfg.1	-	95	24834	c.24610C>A	c.(24610-24612)CTG>ATG	p.L8204M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L4865M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9131							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTTTTCCAGATAACTAATC	0.478			NA											13	65					4.3838e-07	5.4814e-07	0.001855	1	0
TTN	7273	broad.mit.edu	37	2	179641604	179641605	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:179641604_179641605GG>AA	uc010zfg.1	-	28	5210_5211	c.4986_4987CC>TT	c.(4984-4989)ATCCCA>ATTTCA	p.P1663S	TTN_uc010zfh.1_Missense_Mutation_p.P1617S|TTN_uc010zfi.1_Missense_Mutation_p.P1617S|TTN_uc010zfj.1_Missense_Mutation_p.P1617S|TTN_uc002unb.2_Missense_Mutation_p.P1663S|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1663							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCCCCGTGGGATGATTAACT	0.47			NA											14	46					0	0	0.004672	0	0
FAM171B	165215	broad.mit.edu	37	2	187626597	187626597	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:187626597G>T	uc002ups.2	+	8	1640	c.1528G>T	c.(1528-1530)GAT>TAT	p.D510Y	FAM171B_uc002upr.1_Missense_Mutation_p.D477Y|FAM171B_uc002upt.2_5'UTR	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	510	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TGATGCTCAAGATGAAAAGAG	0.423			NA											4	14					0.00909568	0.00967948	0.009096	1	0
FAM171B	165215	broad.mit.edu	37	2	187627401	187627401	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:187627401G>T	uc002ups.2	+	8	2444	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*	FAM171B_uc002upr.1_Nonsense_Mutation_p.E745*|FAM171B_uc002upt.2_Nonsense_Mutation_p.E247*	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	778	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						CCCTGGAGAAGAGTCGCCAGG	0.512			NA											7	30					8.12818e-05	9.20528e-05	0.001984	1	0
HECW2	57520	broad.mit.edu	37	2	197184311	197184311	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:197184311T>A	uc002utm.1	-	9	1486	c.1303A>T	c.(1303-1305)ACC>TCC	p.T435S	HECW2_uc002utl.1_Missense_Mutation_p.T79S	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	435					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						TCAGAGCAGGTCGCTGTCCCC	0.502			NA											11	44					0	0	0.00245	0	0
INO80D	54891	broad.mit.edu	37	2	206869966	206869966	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:206869966C>G	uc002vaz.3	-	11	2615	c.2210G>C	c.(2209-2211)CGT>CCT	p.R737P		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	737					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GGTAGCAGAACGGAGCAGGTT	0.527			NA											16	47					0	0	0.006122	0	0
INO80D	54891	broad.mit.edu	37	2	206911327	206911327	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:206911327C>G	uc002vaz.3	-	5	1379	c.974G>C	c.(973-975)TGG>TCG	p.W325S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	325					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTCTTCAGACCAGTCCAAACC	0.433			NA											11	44					0	0	0.013537	0	0
INO80D	54891	broad.mit.edu	37	2	206921201	206921201	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:206921201C>G	uc002vaz.3	-	4	1090	c.685G>C	c.(685-687)GTC>CTC	p.V229L		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	229					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GACTTGCAGACTGAACCCTGC	0.562			NA											7	29					0	0	0.008291	0	0
MDH1B	130752	broad.mit.edu	37	2	207620124	207620124	+	Silent	SNP	C	C	T	rs111448923		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:207620124C>T	uc002vbs.2	-	5	574	c.519G>A	c.(517-519)GCG>GCA	p.A173A	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.A173A|MDH1B_uc010fuj.2_Silent_p.A75A|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	173					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GATGTTCTTCCGCCTGCTTGT	0.522	Pancreas(76;29 1355 28675 37177 51207)		NA											3	72					0	0	0.004672	0	0
CRYGC	1420	broad.mit.edu	37	2	208994205	208994205	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:208994205C>A	uc002vco.3	-	2	250	c.212G>T	c.(211-213)GGC>GTC	p.G71V		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	71	Beta/gamma crystallin 'Greek key' 2.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GTCGCTGAGGCCCATCCATTG	0.552			NA											23	90					4.26978e-12	6.30953e-12	0.00333	1	0
MAP2	4133	broad.mit.edu	37	2	210560504	210560504	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:210560504A>T	uc002vde.1	+	7	3858	c.3610A>T	c.(3610-3612)AGC>TGC	p.S1204C	MAP2_uc002vdc.1_Missense_Mutation_p.S1204C|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S1200C	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1204					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AAAAGAAGAAAGCAAAGAGAC	0.463	Pancreas(27;423 979 28787 29963)		NA											5	21					0	0	0.000602	0	0
PNKD	25953	broad.mit.edu	37	2	219136165	219136165	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:219136165C>G	uc002vhn.2	+	2	273	c.129C>G	c.(127-129)AGC>AGG	p.S43R	AAMP_uc002vhj.2_5'Flank|AAMP_uc002vhk.2_5'Flank|AAMP_uc010fvo.2_5'Flank|AAMP_uc002vhl.2_5'Flank|PNKD_uc002vhm.1_Missense_Mutation_p.S43R	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	43						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTGCAAAGCCACAGCTCCC	0.557			NA											4	99					0	0	0.009096	0	0
DNPEP	23549	broad.mit.edu	37	2	220247885	220247885	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:220247885C>A	uc010zlg.1	-	10	1010	c.928G>T	c.(928-930)GTG>TTG	p.V310L	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.V302L|DNPEP_uc002vlf.1_Missense_Mutation_p.V288L|DNPEP_uc002vlh.2_Missense_Mutation_p.V249L|DNPEP_uc002vli.1_Missense_Mutation_p.V249L	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	292					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	ACCATGCGCACGTGAGGCTCT	0.572			NA											20	75					1.42536e-11	2.07666e-11	0.004656	1	0
DOCK10	55619	broad.mit.edu	37	2	225639826	225639826	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:225639826G>T	uc010fwz.1	-	52	6048	c.5809C>A	c.(5809-5811)CCC>ACC	p.P1937T	DOCK10_uc002vob.2_Missense_Mutation_p.P1931T|DOCK10_uc002voa.2_Missense_Mutation_p.P593T	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1937	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AAATCCTTGGGGTTTACCTGT	0.502			NA											7	21					0.00198382	0.00215825	0.001984	1	0
KIAA1486	57624	broad.mit.edu	37	2	226378343	226378343	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:226378343A>T	uc002voe.2	+	3	653	c.478A>T	c.(478-480)AGC>TGC	p.S160C	KIAA1486_uc010fxa.1_Intron	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	160										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GACAGTCAGCAGCACTGCAGC	0.532			NA											6	42					0	0	0.00308	0	0
ANKMY1	51281	broad.mit.edu	37	2	241463418	241463418	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:241463418C>A	uc002vyz.1	-	7	1678	c.1449G>T	c.(1447-1449)CAG>CAT	p.Q483H	ANKMY1_uc002vza.1_Missense_Mutation_p.Q342H|ANKMY1_uc010fzd.1_Missense_Mutation_p.Q572H|ANKMY1_uc002vzb.1_Missense_Mutation_p.Q244H|ANKMY1_uc002vzc.1_Missense_Mutation_p.Q342H|ANKMY1_uc002vzd.1_Missense_Mutation_p.Q342H|ANKMY1_uc010fze.1_Missense_Mutation_p.Q152H|ANKMY1_uc002vze.2_Missense_Mutation_p.Q244H	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	483							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCAGCATGGCCTGCGAGAGCT	0.592			NA											26	99					3.99451e-17	6.57033e-17	0.009535	1	0
ANKMY1	51281	broad.mit.edu	37	2	241468821	241468821	+	Missense_Mutation	SNP	T	T	A	rs141100581		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:241468821T>A	uc002vyz.1	-	4	548	c.319A>T	c.(319-321)ACC>TCC	p.T107S	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Missense_Mutation_p.T196S|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	107							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGGATCTGGGTGCACAGCTTG	0.592			NA											12	39					0	0	0.013537	0	0
GPR35	2859	broad.mit.edu	37	2	241569781	241569781	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:241569781G>T	uc002vzs.1	+	1	987	c.412G>T	c.(412-414)GCG>TCG	p.A138S	GPR35_uc010fzh.1_Missense_Mutation_p.A169S|GPR35_uc010fzi.1_Missense_Mutation_p.A169S	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	138	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GGCCGTGTGCGCGGTCCTCTG	0.706			NA											3	31					6.4e-05	7.33993e-05	0.004672	1	0
ATG4B	23192	broad.mit.edu	37	2	242590432	242590432	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:242590432G>T	uc002wbv.2	+	2	121	c.18G>T	c.(16-18)CTG>CTT	p.L6L	ATG4B_uc002wbu.2_5'UTR|ATG4B_uc002wbw.2_Silent_p.L6L|ATG4B_uc010zox.1_5'UTR|ATG4B_uc010zoy.1_5'UTR|ATG4B_uc010fzp.2_Silent_p.L6L|ATG4B_uc010zoz.1_5'Flank	NM_013325	NP_037457	Q9Y4P1	ATG4B_HUMAN	APG4 autophagy 4 homolog B isoform a	6					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		CAGCTACTCTGACCTACGACA	0.418	Melanoma(78;458 1323 6342 12171 39523)		NA											6	20					5.18039e-06	6.22398e-06	0.00308	1	0
SIRPA	140885	broad.mit.edu	37	20	1902288	1902288	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:1902288C>A	uc002wfq.2	+	4	1044	c.684C>A	c.(682-684)TGC>TGA	p.C228*	SIRPA_uc010zps.1_Nonsense_Mutation_p.C208*|SIRPA_uc002wfr.2_Nonsense_Mutation_p.C228*|SIRPA_uc002wfs.2_Nonsense_Mutation_p.C228*|SIRPA_uc002wft.2_Nonsense_Mutation_p.C228*	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	228	Ig-like C1-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		AAGTCATCTGCGAGGTGGCCC	0.612	GBM(155;1668 1920 5945 42733 48121)		NA											13	63					2.5808e-16	4.17867e-16	0.006122	1	0
SLC4A11	83959	broad.mit.edu	37	20	3211846	3211846	+	Silent	SNP	G	G	T	rs138137682	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:3211846G>T	uc002wig.2	-	8	1087	c.1039C>A	c.(1039-1041)CGG>AGG	p.R347R	SLC4A11_uc010zqe.1_Silent_p.R374R|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.R331R	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	347	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						ATGTCCTCCCGGATGCCCTTC	0.632	NSCLC(190;922 2139 10266 10292 38692)		NA											18	89					1.40151e-16	2.28262e-16	0.010504	1	0
SLC4A11	83959	broad.mit.edu	37	20	3211888	3211888	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:3211888G>A	uc002wig.2	-	8	1045	c.997C>T	c.(997-999)CCC>TCC	p.P333S	SLC4A11_uc010zqe.1_Missense_Mutation_p.P360S|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.P317S	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	333	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CACTTTGGGGGCTGGAGGAGA	0.647	NSCLC(190;922 2139 10266 10292 38692)		NA											16	33					0	0	0.004007	0	0
CHGB	1114	broad.mit.edu	37	20	5903076	5903076	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:5903076C>A	uc002wmg.2	+	4	592	c.286C>A	c.(286-288)CAC>AAC	p.H96N	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	96						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CTCGGAAGCCCACGAGTCCTC	0.517			NA											11	38					1.08611e-07	1.38734e-07	0.010729	1	0
PLCB1	23236	broad.mit.edu	37	20	8713960	8713960	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:8713960T>C	uc002wnb.2	+	19	1967	c.1964T>C	c.(1963-1965)ATG>ACG	p.M655T	PLCB1_uc010zrb.1_Missense_Mutation_p.M554T|PLCB1_uc002wna.2_Missense_Mutation_p.M655T|PLCB1_uc002wnc.1_Missense_Mutation_p.M554T|PLCB1_uc002wnd.1_Missense_Mutation_p.M232T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	655	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCAGAGTTCATGAGGAGGCCT	0.423			NA											19	84					0	0	0.010504	0	0
PAK7	57144	broad.mit.edu	37	20	9561032	9561032	+	Silent	SNP	C	C	T	rs144202772	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:9561032C>T	uc002wnl.2	-	5	1295	c.750G>A	c.(748-750)CTG>CTA	p.L250L	PAK7_uc002wnk.2_Silent_p.L250L|PAK7_uc002wnj.2_Silent_p.L250L|PAK7_uc010gby.1_Silent_p.L250L	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	250	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CACTGTACGCCAGGCTCTCCT	0.552			NA											10	63					0	0	0.008291	0	0
JAG1	182	broad.mit.edu	37	20	10644641	10644641	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:10644641C>A	uc002wnw.2	-	3	925	c.409G>T	c.(409-411)GAG>TAG	p.E137*		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	137	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TCCCACGCCTCCACAAGCAAC	0.473			NA							Alagille_Syndrome				16	64					1.67942e-08	2.21694e-08	0.006122	1	0
TASP1	55617	broad.mit.edu	37	20	13610663	13610663	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:13610663C>A	uc002woi.2	-	2	180	c.63G>T	c.(61-63)TCG>TCT	p.S21S	TASP1_uc010zri.1_RNA|TASP1_uc002woh.2_Silent_p.S21S|TASP1_uc010zrj.1_RNA|TASP1_uc010zrk.1_Silent_p.S21S	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	21					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						TTTTACCAGCCGAAACCTGAG	0.468			NA											12	78					1.5842e-08	2.09458e-08	0.001855	1	0
FLRT3	23767	broad.mit.edu	37	20	14307371	14307371	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:14307371C>A	uc002wov.1	-	3	1249	c.782G>T	c.(781-783)CGG>CTG	p.R261L	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R261L	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	261	Extracellular (Potential).|LRR 9.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TGGGGGCACCCGATTGATGTG	0.443			NA											7	39					8.12818e-05	9.20528e-05	0.001984	1	0
KIF16B	55614	broad.mit.edu	37	20	16485072	16485072	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:16485072C>A	uc002wpg.1	-	10	1279	c.1121G>T	c.(1120-1122)CGT>CTT	p.R374L	KIF16B_uc010gch.1_Missense_Mutation_p.R374L|KIF16B_uc010gci.1_Missense_Mutation_p.R374L|KIF16B_uc010gcj.1_Missense_Mutation_p.R374L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	374	Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TCGCAGCTCACGGATAAGTTT	0.408			NA											27	121					3.1745e-13	4.83761e-13	0.008361	1	0
TMEM90B	79953	broad.mit.edu	37	20	24646039	24646039	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:24646039G>T	uc002wtw.1	+	4	1309	c.676G>T	c.(676-678)GCC>TCC	p.A226S		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	226	Extracellular (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CTCCCGGCGGGCCCTATTCCT	0.587			NA											28	155					1.30988e-24	2.3055e-24	0.010818	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353			NA											3	52					0	0	0.004672	0	0
ITCH	83737	broad.mit.edu	37	20	33068418	33068418	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:33068418G>T	uc010geu.1	+	20	2148	c.1956G>T	c.(1954-1956)GGG>GGT	p.G652G	ITCH_uc002xak.2_Silent_p.G611G|ITCH_uc010zuj.1_Silent_p.G501G	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	652	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TGTTCCATGGGAAATTCATAG	0.308			NA											17	64					7.41877e-09	9.93564e-09	0.012319	1	0
NCOA6	23054	broad.mit.edu	37	20	33345462	33345462	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:33345462T>G	uc002xav.2	-	8	3660	c.1089A>C	c.(1087-1089)TTA>TTC	p.L363F	NCOA6_uc002xaw.2_Missense_Mutation_p.L363F|NCOA6_uc010gew.1_Missense_Mutation_p.L320F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	363	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GTACCGTGGCTAAGGATGGTC	0.582			NA											22	92					0	0	0.00632	0	0
CEP250	11190	broad.mit.edu	37	20	34090820	34090820	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:34090820G>C	uc002xcm.2	+	31	5294	c.4623G>C	c.(4621-4623)CAG>CAC	p.Q1541H	CEP250_uc010zve.1_Missense_Mutation_p.Q909H	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1541	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TTGAGTCCCAGAGAGGACAGG	0.493			NA											5	58					0	0	0.000602	0	0
DHX35	60625	broad.mit.edu	37	20	37634934	37634934	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:37634934C>T	uc002xjh.2	+	12	1168	c.1157C>T	c.(1156-1158)TCA>TTA	p.S386L	DHX35_uc010zwa.1_Missense_Mutation_p.S231L|DHX35_uc010zwb.1_Missense_Mutation_p.S231L|DHX35_uc010zwc.1_Missense_Mutation_p.S355L	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	386	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TCCCAGGCATCAGCTAATCAG	0.502			NA											5	242					0	0	0.000602	0	0
SEMG2	6407	broad.mit.edu	37	20	43851221	43851221	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:43851221C>A	uc010ggz.2	+	2	1005	c.948C>A	c.(946-948)ATC>ATA	p.I316I	SEMG2_uc002xnk.2_Silent_p.I316I|SEMG2_uc002xnl.2_Silent_p.I316I	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	316	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GCATTTCTATCCAAACTGAAG	0.363			NA											11	42					0.000673444	0.000743389	0.008291	1	0
ZSWIM3	140831	broad.mit.edu	37	20	44507109	44507109	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:44507109C>A	uc002xqd.2	+	2	2115	c.1912C>A	c.(1912-1914)CTG>ATG	p.L638M	ZSWIM3_uc010zxg.1_Missense_Mutation_p.L632M|ZSWIM1_uc010zxh.1_5'Flank|ZSWIM1_uc010ghi.2_5'Flank	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	638							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				GGGGCCAGAGCTGGAGGAACG	0.572			NA											20	194					2.89027e-11	4.1962e-11	0.014323	1	0
PCIF1	63935	broad.mit.edu	37	20	44567633	44567633	+	Translation_Start_Site	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:44567633G>A	uc002xqs.2	+	3	309	c.-5G>A	c.(-7--3)GTGTG>GTATG			NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1							nucleus				skin(1)	1						CTGTGTGGGTGTGGAGATGGC	0.612			NA											18	135					0	0	0.010504	0	0
NCOA3	8202	broad.mit.edu	37	20	46279833	46279833	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:46279833G>A	uc002xtk.2	+	20	3964	c.3759G>A	c.(3757-3759)CAG>CAA	p.Q1253Q	NCOA3_uc010ght.1_Silent_p.Q1244Q|NCOA3_uc002xtl.2_Silent_p.Q1249Q|NCOA3_uc002xtm.2_Silent_p.Q1248Q|NCOA3_uc002xtn.2_Silent_p.Q1252Q|NCOA3_uc010zyc.1_Silent_p.Q1048Q	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1253	Poly-Gln.|Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						agcagcagcagcaacagcagc	0.289			NA											3	38					0	0	0.004672	0	0
CYP24A1	1591	broad.mit.edu	37	20	52773741	52773741	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:52773741G>A	uc002xwv.2	-	11	1920	c.1522C>T	c.(1522-1524)CCC>TCC	p.P508S	CYP24A1_uc002xwu.1_Missense_Mutation_p.P366S|CYP24A1_uc002xww.2_Missense_Mutation_p.P442S	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	508					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	AACGCGATGGGGAGTTCCCGG	0.448			NA											6	29					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	20	56063859	56063859	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:56063859C>T	uc010zzl.1	-	1	225	c.225G>A	c.(223-225)ATG>ATA	p.M75I		NM_001008735	NP_001008735			high-mobility group box 1-like 1												NA						TATAGGTTTTCATTTGTCTTT	0.458			NA											11	96					0	0	0.013537	0	0
ZNF831	128611	broad.mit.edu	37	20	57769423	57769423	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:57769423G>T	uc002yan.2	+	1	3349	c.3349G>T	c.(3349-3351)GGG>TGG	p.G1117W		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1117						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCCTTCTTCAGGGCCCCTGGT	0.667			NA											11	54					5.50884e-06	6.60901e-06	0.013537	1	0
LAMA5	3911	broad.mit.edu	37	20	60885062	60885062	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:60885062G>A	uc002ycq.2	-	78	10877	c.10810C>T	c.(10810-10812)CAG>TAG	p.Q3604*		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3604	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGTGCCACTGGCCATCACAC	0.697			NA											6	48					0	0	0.00308	0	0
NTSR1	4923	broad.mit.edu	37	20	61391515	61391515	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:61391515G>T	uc002ydf.2	+	4	1524	c.1153G>T	c.(1153-1155)GTG>TTG	p.V385L		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	385	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CCTCTGCCCGGTGTGGCGGCG	0.622	GBM(37;400 780 6403 19663 35669)		NA											25	118					1.2476e-16	2.03594e-16	0.00632	1	0
COL20A1	57642	broad.mit.edu	37	20	61957465	61957465	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:61957465G>T	uc011aau.1	+	30	3520	c.3420G>T	c.(3418-3420)GAG>GAT	p.E1140D	COL20A1_uc011aav.1_Missense_Mutation_p.E961D	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1140	Collagen-like 2.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GAGGCCTGGAGGGAACTGCTG	0.667			NA											11	71					0.000308642	0.000343903	0.003163	1	0
APP	351	broad.mit.edu	37	21	27328036	27328036	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr21:27328036C>T	uc002ylz.2	-	12	1692	c.1492G>A	c.(1492-1494)GTC>ATC	p.V498I	APP_uc011acg.1_Missense_Mutation_p.V6I|APP_uc010glk.2_Missense_Mutation_p.V474I|APP_uc002yma.2_Missense_Mutation_p.V479I|APP_uc011ach.1_Missense_Mutation_p.V442I|APP_uc002ymb.2_Missense_Mutation_p.V423I|APP_uc010glj.2_Missense_Mutation_p.V367I|APP_uc011aci.1_Missense_Mutation_p.V388I	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	498	Heparin-binding.|Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TCTGCGCGGACATACTTCTTT	0.483			NA											26	57					0	0	0.012213	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410681	32410681	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr21:32410681C>A	uc010glt.2	-	1	115	c.82G>T	c.(82-84)GGC>TGC	p.G28C		NM_001099219	NP_001092689	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	28						intermediate filament				upper_aerodigestive_tract(1)	1						CTGCCATAGCCGCAGCCATAG	0.537			NA											26	146					3.65163e-15	5.84402e-15	0.00632	1	0
TIAM1	7074	broad.mit.edu	37	21	32526654	32526654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr21:32526654G>A	uc002yow.1	-	18	3554	c.3082C>T	c.(3082-3084)CAG>TAG	p.Q1028*	TIAM1_uc011adk.1_Nonsense_Mutation_p.Q1028*|TIAM1_uc011adl.1_Nonsense_Mutation_p.Q968*	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1028					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GTCGCCAGCTGAGGCCCCGTG	0.567			NA											6	83					0	0	0.001984	0	0
RIPK4	54101	broad.mit.edu	37	21	43166827	43166827	+	Missense_Mutation	SNP	G	G	T	rs149749209		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr21:43166827G>T	uc002yzn.1	-	5	826	c.778C>A	c.(778-780)CGC>AGC	p.R260S		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	260						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGCATGAGGCGTATCAGGTGG	0.672			NA											4	92					0.00024832	0.000278186	0.009096	1	0
ITGB2	3689	broad.mit.edu	37	21	46319066	46319066	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr21:46319066C>T	uc002zgd.2	-	7	953	c.909G>A	c.(907-909)TCG>TCA	p.S303S	ITGB2_uc002zge.2_Silent_p.S303S|ITGB2_uc002zgf.3_Silent_p.S303S|ITGB2_uc011afl.1_Silent_p.S225S|ITGB2_uc010gpw.2_Silent_p.S246S|ITGB2_uc002zgg.2_Silent_p.S303S	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	303	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCTGGCCCACCGATGGGTAGT	0.622			NA											8	39					0	0	0.004482	0	0
OR11H1	81061	broad.mit.edu	37	22	16449068	16449068	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:16449068C>A	uc011agd.1	-	1	737	c.737G>T	c.(736-738)AGC>ATC	p.S246I		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	246	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		TCTCCCAGTGCTTGAAGGCAT	0.428			NA											36	128					1.15181e-12	1.73609e-12	0.01441	1	0
CECR5	27440	broad.mit.edu	37	22	17619447	17619447	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:17619447C>A	uc002zmf.2	-	7	956	c.928G>T	c.(928-930)GCT>TCT	p.A310S	CECR5_uc002zmd.2_Missense_Mutation_p.A121S|CECR5_uc002zme.2_Missense_Mutation_p.A102S|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.A280S	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	310							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				TACCCCACAGCATAGAGCTTC	0.577			NA											24	130					1.1804e-14	1.86746e-14	0.003954	1	0
CCDC116	164592	broad.mit.edu	37	22	21991000	21991000	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:21991000C>T	uc002zve.2	+	5	1576	c.1483C>T	c.(1483-1485)CGG>TGG	p.R495W		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	495										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GGAGACCCACCGGAGCTGCCT	0.622			NA											17	68					0	0	0.014323	0	0
SMARCB1	6598	broad.mit.edu	37	22	24145550	24145550	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:24145550G>T	uc002zyb.2	+	5	776	c.569G>T	c.(568-570)CGG>CTG	p.R190L	SMARCB1_uc002zya.2_Missense_Mutation_p.R190L|SMARCB1_uc002zyc.2_Missense_Mutation_p.R181L|SMARCB1_uc002zyd.2_Missense_Mutation_p.R199L|SMARCB1_uc002zye.1_Missense_Mutation_p.R116L|SMARCB1_uc002zyf.1_RNA|SMARCB1_uc010gue.1_RNA	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	190	HIV-1 integrase-binding.|1.|2 X approximate tandem repeats.|MYC-binding.				cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(6)|p.V185_M193del(1)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				GTCCCCATCCGGCTGGACATG	0.582			NA	D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				22	89					9.62636e-23	1.68005e-22	0.014323	1	0
MYO18B	84700	broad.mit.edu	37	22	26423231	26423231	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:26423231C>A	uc003abz.1	+	43	7541	c.7291C>A	c.(7291-7293)CTC>ATC	p.L2431I	MYO18B_uc003aca.1_Missense_Mutation_p.L2312I|MYO18B_uc010guy.1_Missense_Mutation_p.L2313I|MYO18B_uc010guz.1_Missense_Mutation_p.L2311I|MYO18B_uc011aka.1_Missense_Mutation_p.L1585I|MYO18B_uc011akb.1_Missense_Mutation_p.L1944I|MYO18B_uc010gva.1_Missense_Mutation_p.L414I|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2431						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						ACTCCCAAGCCTCGACTACGA	0.557			NA											24	103					9.86323e-18	1.6386e-17	0.003954	1	0
TFIP11	24144	broad.mit.edu	37	22	26899709	26899709	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:26899709C>T	uc003acr.2	-	6	945	c.571G>A	c.(571-573)GGG>AGG	p.G191R	TFIP11_uc003acs.2_Missense_Mutation_p.G191R|TFIP11_uc003act.2_Missense_Mutation_p.G191R	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	191	G-patch.				biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCATAAGCCCCCACAGCACCT	0.468			NA											9	49					0	0	0.006214	0	0
CCDC157	550631	broad.mit.edu	37	22	30762169	30762169	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:30762169C>T	uc011aku.1	+	3	840	c.180C>T	c.(178-180)GAC>GAT	p.D60D	CCDC157_uc011akv.1_Silent_p.D60D	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	60										central_nervous_system(1)	1						AGCACTATGACCATGTTCCGG	0.637			NA											26	180					0	0	0.00632	0	0
SEC14L3	266629	broad.mit.edu	37	22	30863060	30863060	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:30863060C>A	uc003ahy.2	-	6	517	c.428G>T	c.(427-429)GGG>GTG	p.G143V	SEC14L3_uc003ahz.2_Missense_Mutation_p.G66V|SEC14L3_uc003aia.2_Missense_Mutation_p.G84V|SEC14L3_uc003aib.2_Missense_Mutation_p.G84V	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	143	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	AATCTTCTTCCCTAGCTGCAA	0.488	Esophageal Squamous(108;290 1516 3584 23771 37333)		NA											30	109					8.4185e-14	1.29479e-13	0.012213	1	0
SMTN	6525	broad.mit.edu	37	22	31491288	31491288	+	Splice_Site	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:31491288G>C	uc003ajl.1	+	12	1851	c.1633_splice	c.e12-1	p.M545_splice	SMTN_uc003ajk.1_Splice_Site_p.M545_splice|SMTN_uc003ajm.1_Splice_Site_p.M545_splice|SMTN_uc011ale.1_Splice_Site_p.M630_splice|SMTN_uc011alf.1_Splice_Site_p.M601_splice|SMTN_uc003ajn.1_Splice_Site_p.M568_splice|SMTN_uc011alg.1_Splice_Site_p.M1_splice|SMTN_uc003ajo.1_Splice_Site_p.M144_splice|SMTN_uc011alh.1_Splice_Site|SMTN_uc010gwe.1_Splice_Site_p.M1_splice	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c						muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						CCACCCTGCAGATGGAAGCAG	0.592			NA											3	47					0	0	0.000602	0	0
PICK1	9463	broad.mit.edu	37	22	38465057	38465057	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:38465057C>T	uc003auq.2	+	6	757	c.367C>T	c.(367-369)CAC>TAC	p.H123Y	PICK1_uc003aur.2_Missense_Mutation_p.H123Y|PICK1_uc003aus.2_Missense_Mutation_p.H123Y|PICK1_uc003aut.2_Missense_Mutation_p.H123Y	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	123					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					GAAAGTCAAGCACCGGCTGGT	0.627			NA											4	22					0	0	0.000602	0	0
TCF20	6942	broad.mit.edu	37	22	42605808	42605808	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:42605808C>A	uc003bcj.1	-	1	5638	c.5504G>T	c.(5503-5505)GGC>GTC	p.G1835V	TCF20_uc003bck.1_Missense_Mutation_p.G1835V|TCF20_uc003bnt.2_Missense_Mutation_p.G1835V	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CAGCTCAGGGCCACCTTCTGA	0.517			NA											46	135					4.53422e-39	8.26124e-39	0.01441	1	0
SCUBE1	80274	broad.mit.edu	37	22	43735195	43735195	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:43735195G>A	uc003bdt.1	-	2	223	c.135C>T	c.(133-135)CAC>CAT	p.H45H	SCUBE1_uc003bdu.1_Silent_p.H45H	NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	45	EGF-like 1; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				TGGCATCGATGTGGCAGTCAT	0.592			NA											8	70					0	0	0.00308	0	0
WNT7B	7477	broad.mit.edu	37	22	46345813	46345813	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:46345813T>A	uc003bgo.2	-	2	659	c.285A>T	c.(283-285)CAA>CAT	p.Q95H	WNT7B_uc010haa.2_Missense_Mutation_p.Q99H	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	95					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGGAGCTCTTGCCCGAAGA	0.662			NA											9	38					0	0	0.006214	0	0
PLXNB2	23654	broad.mit.edu	37	22	50716158	50716158	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:50716158G>A	uc003bkv.3	-	33	5164	c.5058C>T	c.(5056-5058)CTC>CTT	p.L1686L	PLXNB2_uc003bkt.1_Silent_p.L478L|PLXNB2_uc003bku.1_Silent_p.L671L	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1686	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCCAGAACCGGAGCGGTAAGC	0.647			NA											8	129					0	0	0.00308	0	0
CHL1	10752	broad.mit.edu	37	3	439977	439977	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:439977G>T	uc003bou.2	+	24	3385	c.3114G>T	c.(3112-3114)GAG>GAT	p.E1038D	CHL1_uc003bot.2_Missense_Mutation_p.E1054D|CHL1_uc003bow.1_Missense_Mutation_p.E1038D|CHL1_uc011asi.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1038	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGGTATTTGAGCCGGGAGCTG	0.378			NA											12	38					2.27111e-07	2.85698e-07	0.013537	1	0
SRGAP3	9901	broad.mit.edu	37	3	9034648	9034648	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:9034648C>T	uc003brf.1	-	20	3176	c.2500G>A	c.(2500-2502)GAC>AAC	p.D834N	SRGAP3_uc003brg.1_Missense_Mutation_p.D810N	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	834					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GACTGGAGGTCGTTTTTGGAA	0.582			NA	T	RAF1	pilocytic astrocytoma								3	49					0	0	0.004672	0	0
RAF1	5894	broad.mit.edu	37	3	12645693	12645693	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:12645693G>A	uc003bxf.3	-	7	1191	c.776C>T	c.(775-777)TCC>TTC	p.S259F	RAF1_uc011aut.1_Missense_Mutation_p.S44F|RAF1_uc011auu.1_Missense_Mutation_p.S177F	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	259			S -> A (in an ovarian serous carcinoma sample; somatic mutation).|S -> F (in NS5).	S->A: Increased ERK activation.	activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.S259A(1)	ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	ATTAGGTGTGGATGTCGACCT	0.517			NA	T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				6	76					0	0	0.001984	0	0
NUP210	23225	broad.mit.edu	37	3	13438872	13438872	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:13438872C>A	uc003bxv.1	-	3	504	c.421G>T	c.(421-423)GCC>TCC	p.A141S		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	141	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GAGTCCAGGGCCTGGATCTTC	0.597			NA											8	33					3.09899e-07	3.88075e-07	0.004482	1	0
C3orf20	84077	broad.mit.edu	37	3	14798905	14798905	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:14798905C>A	uc003byy.2	+	13	2372	c.1968C>A	c.(1966-1968)CCC>CCA	p.P656P	C3orf20_uc003byz.2_Silent_p.P534P|C3orf20_uc003bza.2_Silent_p.P534P|C3orf20_uc003bzb.1_Silent_p.P157P|C3orf20_uc011avj.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	656						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GGCGCAGCCCCACCAGGTGGG	0.672			NA											5	18					1.23904e-05	1.45697e-05	0.000602	1	0
ARPP21	10777	broad.mit.edu	37	3	35835217	35835217	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:35835217G>A	uc003cgb.2	+	20	2470	c.2206G>A	c.(2206-2208)GGA>AGA	p.G736R	ARPP21_uc003cga.2_Missense_Mutation_p.G717R|ARPP21_uc011axy.1_Missense_Mutation_p.G737R|ARPP21_uc003cgf.2_Missense_Mutation_p.G572R|ARPP21_uc003cgg.2_Missense_Mutation_p.G259R	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	736	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGGTTCTCAAGGACTGCCCCA	0.438			NA											6	57					0	0	0.001168	0	0
SLC22A14	9389	broad.mit.edu	37	3	38348825	38348825	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:38348825C>T	uc010hhc.1	+	3	639	c.597C>T	c.(595-597)CTC>CTT	p.L199L	SLC22A14_uc003cia.2_Silent_p.L199L|SLC22A14_uc003cib.2_Silent_p.L199L|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	199	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		TAGGCTCTCTCATCTTCAGGC	0.542			NA											13	99					0	0	0.004007	0	0
SCN5A	6331	broad.mit.edu	37	3	38639443	38639443	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:38639443C>T	uc003cio.2	-	14	2233	c.2039G>A	c.(2038-2040)CGC>CAC	p.R680H	SCN5A_uc003cin.2_Missense_Mutation_p.R680H|SCN5A_uc003cil.3_Missense_Mutation_p.R680H|SCN5A_uc010hhi.2_Missense_Mutation_p.R680H|SCN5A_uc010hhk.2_Missense_Mutation_p.R680H|SCN5A_uc011ayr.1_Missense_Mutation_p.R680H|SCN5A_uc010hhj.1_Missense_Mutation_p.R291H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	680			R -> H (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACACTTGTGGCGAGACTCCTC	0.507			NA											13	77					0	0	0.00245	0	0
SCN10A	6336	broad.mit.edu	37	3	38770075	38770075	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:38770075G>T	uc003ciq.2	-	15	2598	c.2598C>A	c.(2596-2598)TGC>TGA	p.C866*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	866	II.|Helical; Name=S6 of repeat II; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AAAGGATGAGGCATATGGATT	0.527			NA											13	45					2.32078e-09	3.14368e-09	0.003163	1	0
SCN10A	6336	broad.mit.edu	37	3	38835477	38835477	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:38835477C>T	uc003ciq.2	-	1	25	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	9					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGTTAGTTTCGAGGGATCCA	0.453			NA											18	130					0	0	0.014323	0	0
HHATL	57467	broad.mit.edu	37	3	42734344	42734344	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:42734344T>A	uc003clw.2	-	13	1561	c.1414A>T	c.(1414-1416)ATC>TTC	p.I472F	HHATL_uc003clx.2_Missense_Mutation_p.I472F	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	472	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		ACAAACAGGATGGACAGCGTG	0.582			NA											4	54					0	0	0.009096	0	0
ZNF167	55888	broad.mit.edu	37	3	44612228	44612228	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:44612228G>T	uc010hin.2	+	6	2014	c.1626G>T	c.(1624-1626)CAG>CAT	p.Q542H	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.Q542H|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	542	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TTGACCATCAGAGAATCCACA	0.463	Esophageal Squamous(121;907 1626 38429 48584 52774)		NA											7	74					0.000157383	0.00017703	0.00308	1	0
TGM4	7047	broad.mit.edu	37	3	44929264	44929264	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:44929264C>A	uc003coc.3	+	3	350	c.277C>A	c.(277-279)CTT>ATT	p.L93I	TGM4_uc003coa.2_Missense_Mutation_p.L93I|TGM4_uc003cob.2_Intron	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	93					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GCAGGCAACCCTTCAAAATGA	0.612			NA											18	59					1.33834e-09	1.82181e-09	0.007413	1	0
TGM4	7047	broad.mit.edu	37	3	44952822	44952822	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:44952822C>A	uc003coc.3	+	13	1910	c.1837C>A	c.(1837-1839)CTG>ATG	p.L613M		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	613					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CAAGAATACCCTGGCCATCCC	0.493			NA											10	116					1.58986e-06	1.94395e-06	0.008291	1	0
FBXW12	285231	broad.mit.edu	37	3	48421036	48421036	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:48421036T>C	uc003csr.2	+	7	948	c.762T>C	c.(760-762)CGT>CGC	p.R254R	FBXW12_uc010hjv.2_Silent_p.R235R|FBXW12_uc003css.2_Silent_p.R184R|FBXW12_uc010hjw.2_Silent_p.R153R	NM_207102	NP_996985	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12 isoform	254											0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATACAGTCGTACCTTGCCAC	0.418			NA											13	140					0	0	0.003163	0	0
COL7A1	1294	broad.mit.edu	37	3	48619155	48619155	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:48619155C>A	uc003ctz.2	-	48	4707	c.4706G>T	c.(4705-4707)GGA>GTA	p.G1569V	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1569	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCTTGGACTCCGGTAGCTCC	0.592			NA											28	115					1.16021e-09	1.58977e-09	0.007291	1	0
COL7A1	1294	broad.mit.edu	37	3	48628112	48628112	+	Missense_Mutation	SNP	G	G	A	rs147470888		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:48628112G>A	uc003ctz.2	-	13	1775	c.1774C>T	c.(1774-1776)CGC>TGC	p.R592C		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	592	Fibronectin type-III 4.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCACCCCGGCGGACAGTGAGG	0.597			NA											26	59					0	0	0.004656	0	0
UBA7	7318	broad.mit.edu	37	3	49847796	49847796	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:49847796C>A	uc003cxr.2	-	13	1704	c.1533G>T	c.(1531-1533)CCG>CCT	p.P511P		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	511	1-2.|2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGTAGGTGAGCGGGATCACCT	0.597			NA											26	116					2.24059e-21	3.87777e-21	0.00632	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64633707	64633707	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:64633707C>A	uc003dmg.2	-	11	1651	c.1619G>T	c.(1618-1620)CGG>CTG	p.R540L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R512L|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R369L|ADAMTS9_uc003dmk.1_Missense_Mutation_p.R540L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	540	Disintegrin.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCACCAGAGCCGTCTGCACTG	0.473			NA											23	89					7.92952e-12	1.15732e-11	0.003954	1	0
OR5H2	79310	broad.mit.edu	37	3	98001766	98001766	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:98001766C>T	uc003dsj.1	+	1	35	c.35C>T	c.(34-36)ACA>ATA	p.T12I		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GATAATACAACATTGCTGACA	0.408			NA											24	130					0	0	0.004656	0	0
CCDC54	84692	broad.mit.edu	37	3	107096967	107096967	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:107096967C>A	uc003dwi.1	+	1	780	c.533C>A	c.(532-534)ACT>AAT	p.T178N		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	178											0						CAACCAGCAACTCTGAAGAAC	0.423			NA											23	54					2.39556e-15	3.84124e-15	0.00278	1	0
DZIP3	9666	broad.mit.edu	37	3	108363053	108363053	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:108363053A>T	uc003dxd.2	+	14	1606	c.1184A>T	c.(1183-1185)CAT>CTT	p.H395L	DZIP3_uc003dxf.1_Missense_Mutation_p.H395L|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.H395L|DZIP3_uc003dxg.1_Missense_Mutation_p.H118L	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	395					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TATTTCTATCATCTGCTTCAT	0.308			NA											8	25					0	0	0.004482	0	0
GUCA1C	9626	broad.mit.edu	37	3	108672552	108672552	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:108672552G>T	uc003dxj.2	-	1	126	c.58C>A	c.(58-60)CAT>AAT	p.H20N	GUCA1C_uc003dxk.2_Missense_Mutation_p.H20N	NM_005459	NP_005450	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	20	EF-hand 1.				signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						TACCACACATGGGTCTCTTGT	0.433	NSCLC(157;1360 1999 30631 40189 44208)		NA											8	65					0.00621372	0.0066725	0.006214	1	0
C3orf30	152405	broad.mit.edu	37	3	118870133	118870133	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:118870133G>T	uc003ecb.1	+	3	1645	c.1605G>T	c.(1603-1605)CAG>CAT	p.Q535H	C3orf30_uc011biw.1_Missense_Mutation_p.Q534H	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	535										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		TGCTGTGCCAGGTATAGAATT	0.259			NA											15	139					0.00400662	0.0043475	0.004007	1	0
POPDC2	64091	broad.mit.edu	37	3	119367326	119367326	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:119367326G>A	uc003ecx.1	-	3	924	c.790C>T	c.(790-792)CTT>TTT	p.L264F	POPDC2_uc010hqw.1_Missense_Mutation_p.L264F|POPDC2_uc003ecy.1_Missense_Mutation_p.L82F	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	264						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		AGGCTGGGAAGGCGGATGTCA	0.557			NA											9	65					0	0	0.004482	0	0
SEMA5B	54437	broad.mit.edu	37	3	122645471	122645471	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:122645471G>T	uc003efz.1	-	9	1208	c.904C>A	c.(904-906)CGG>AGG	p.R302R	SEMA5B_uc011bju.1_Silent_p.R244R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.R302R|SEMA5B_uc010hro.1_Silent_p.R244R|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	302	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GCGTTCTCCCGCAGGAAGAAG	0.612			NA											14	40					0.000151284	0.000170632	0.001855	1	0
KALRN	8997	broad.mit.edu	37	3	124438088	124438088	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:124438088C>A	uc003ehg.2	+	60	8859	c.8732C>A	c.(8731-8733)GCC>GAC	p.A2911D	KALRN_uc003ehk.2_Missense_Mutation_p.A1214D	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2910	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGCAATGCTGCCAGAGATTTC	0.512			NA											7	42					0.00829132	0.00888049	0.008291	1	0
PIK3R4	30849	broad.mit.edu	37	3	130400427	130400428	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:130400427_130400428CC>AA	uc003enj.2	-	17	4196_4197	c.3615_3616GG>TT	c.(3613-3618)CAGGGC>CATTGC	p.1205_1206QG>HC		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1205_1206	WD 5.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TCGTTGTTGCCCTGAACAGCTA	0.436			NA											5	54					0	0	0.004672	0	0
NPHP3	27031	broad.mit.edu	37	3	132416140	132416140	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:132416140T>A	uc003epe.1	-	14	2129	c.2052A>T	c.(2050-2052)GAA>GAT	p.E684D	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	684					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CAGAGTGGCATTCTGCAATTA	0.308			NA											17	59					0	0	0.012319	0	0
RBP1	5947	broad.mit.edu	37	3	139257718	139257718	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:139257718G>A	uc003eti.2	-	2	454	c.343C>T	c.(343-345)CGC>TGC	p.R115C	RBP1_uc011bmx.1_Missense_Mutation_p.R115C|RBP1_uc010huj.2_RNA|RBP1_uc011bmy.1_Missense_Mutation_p.R115C	NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	53						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CTCAGCGTGCGGATGATCATA	0.522			NA											10	92					0	0	0.006214	0	0
ACPL2	92370	broad.mit.edu	37	3	141011153	141011153	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:141011153C>T	uc003etu.2	+	8	848	c.549C>T	c.(547-549)ATC>ATT	p.I183I	ACPL2_uc003etv.2_Silent_p.I183I|ACPL2_uc011bna.1_Silent_p.I145I|ACPL2_uc011bnb.1_Silent_p.I166I	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	183						extracellular region	acid phosphatase activity			skin(1)	1						TGAGGGATATCTATCTAAAGA	0.478			NA											20	59					0	0	0.00278	0	0
ZIC1	7545	broad.mit.edu	37	3	147128661	147128661	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:147128661G>T	uc003ewe.2	+	1	1481	c.762G>T	c.(760-762)ACG>ACT	p.T254T		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	254	C2H2-type 1; atypical.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGCTAGTTACGCACGTCACCG	0.557			NA											5	78					8.12818e-05	9.20528e-05	0.001984	1	0
IGSF10	285313	broad.mit.edu	37	3	151156248	151156248	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:151156248C>A	uc011bod.1	-	6	6101	c.6101G>T	c.(6100-6102)AGA>ATA	p.R2034I	IGSF10_uc011bob.1_Missense_Mutation_p.R61I|IGSF10_uc011boc.1_Missense_Mutation_p.R13I	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2034	Ig-like C2-type 6.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGTTTCAGTCTTAGGCTAAC	0.428			NA											14	86					1.49906e-05	1.75774e-05	0.00245	1	0
IGSF10	285313	broad.mit.edu	37	3	151161241	151161241	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:151161241G>A	uc011bod.1	-	5	5494	c.5494C>T	c.(5494-5496)CTG>TTG	p.L1832L	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1832	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTTTAACCAGCAGTGAATCC	0.473			NA											5	26					0	0	0.001984	0	0
BCHE	590	broad.mit.edu	37	3	165547998	165547998	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:165547998G>T	uc003fem.3	-	2	984	c.824C>A	c.(823-825)GCT>GAT	p.A275D	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	275					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AGTCAATTTAGCTAAGTTCAA	0.388			NA											6	80					0.00198382	0.00215825	0.001984	1	0
SAMD7	344658	broad.mit.edu	37	3	169637306	169637306	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:169637306T>A	uc003fgd.2	+	3	287	c.20T>A	c.(19-21)TTG>TAG	p.L7*	SAMD7_uc003fge.2_Nonsense_Mutation_p.L7*|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	7										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AACCCTTTATTGACACCAACA	0.423			NA											20	93					0	0	0.00333	0	0
ACTL6A	86	broad.mit.edu	37	3	179292203	179292203	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:179292203G>C	uc003fjw.2	+	5	597	c.424G>C	c.(424-426)GAA>CAA	p.E142Q	ACTL6A_uc003fjx.2_Missense_Mutation_p.E100Q|ACTL6A_uc003fjy.2_Missense_Mutation_p.E100Q	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	142					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			GTTAATGTTTGAACACTACAA	0.358			NA											19	121					0	0	0.012319	0	0
ECE2	9718	broad.mit.edu	37	3	183975374	183975374	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:183975374G>T	uc003fni.3	+	2	348	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ECE2_uc003fnh.3_Missense_Mutation_p.V104L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	104	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCATGCCCATGTGCCGCAGCT	0.602			NA											18	45					5.35267e-07	6.68277e-07	0.007413	1	0
IGF2BP2	10644	broad.mit.edu	37	3	185376161	185376161	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:185376161G>A	uc003fpo.2	-	11	1316	c.1237C>T	c.(1237-1239)CAC>TAC	p.H413Y	IGF2BP2_uc010hyi.2_Missense_Mutation_p.H356Y|IGF2BP2_uc010hyj.2_Missense_Mutation_p.H350Y|IGF2BP2_uc010hyk.2_Missense_Mutation_p.H277Y|IGF2BP2_uc010hyl.2_Missense_Mutation_p.H307Y|IGF2BP2_uc003fpp.2_Missense_Mutation_p.H370Y|IGF2BP2_uc003fpq.2_Missense_Mutation_p.H418Y	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	413					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CCAAACTGGTGATGGGGGTAC	0.612			NA											13	114					0	0	0.004007	0	0
RFC4	5984	broad.mit.edu	37	3	186512499	186512499	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:186512499G>A	uc003fqz.2	-	5	581	c.358C>T	c.(358-360)CGA>TGA	p.R120*	RFC4_uc011bsc.1_Nonsense_Mutation_p.R120*|RFC4_uc011bsd.1_Nonsense_Mutation_p.R120*	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	120					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		ACTTTCTCTCGAACTACTTGT	0.348			NA											8	36					0	0	0.006214	0	0
CPN2	1370	broad.mit.edu	37	3	194062715	194062715	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr3:194062715C>T	uc003fts.2	-	2	807	c.717G>A	c.(715-717)CAG>CAA	p.Q239Q		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	239	LRR 6.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GGCAGAAGAGCTGGGAGAACA	0.597			NA											8	44					0	0	0.004482	0	0
OTOP1	133060	broad.mit.edu	37	4	4204256	4204256	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:4204256C>A	uc003ghp.1	-	4	679	c.649G>T	c.(649-651)GGC>TGC	p.G217C		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	217					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGAGGACGCCATTGGCCCAC	0.522			NA											22	106					7.07758e-08	9.1249e-08	0.004656	1	0
D4S234E	27065	broad.mit.edu	37	4	4418977	4418977	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:4418977C>A	uc011bvz.1	+	8	1654	c.373C>A	c.(373-375)CCA>ACA	p.P125T	D4S234E_uc011bwa.1_Missense_Mutation_p.P86T|D4S234E_uc003ghz.2_Missense_Mutation_p.P125T|D4S234E_uc003gia.2_Missense_Mutation_p.P125T|D4S234E_uc003gib.2_Missense_Mutation_p.P125T	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	125	Lumenal (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		CCAGTGCATCCCAGAAGGCTT	0.507			NA											11	60					1.61879e-10	2.29791e-10	0.013537	1	0
PCDH7	5099	broad.mit.edu	37	4	30732382	30732382	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:30732382T>C	uc003gsk.1	+	2	4190	c.3182T>C	c.(3181-3183)CTA>CCA	p.L1061P	PCDH7_uc011bxw.1_Intron|PCDH7_uc011bxx.1_Intron	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1061	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CAGATGCGTCTACATCCATAC	0.378			NA											10	72					0	0	0.008291	0	0
ATP8A1	10396	broad.mit.edu	37	4	42576725	42576725	+	Splice_Site	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:42576725C>A	uc003gwr.2	-	14	1439	c.1207_splice	c.e14-1	p.V403_splice	ATP8A1_uc003gws.2_Splice_Site_p.V403_splice|ATP8A1_uc011byz.1_Splice_Site_p.V403_splice	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TGTATTTAACCTAAAAAAGTT	0.338			NA											6	17					8.12818e-05	9.20528e-05	0.001984	1	0
GABRG1	2565	broad.mit.edu	37	4	46053597	46053597	+	Silent	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:46053597A>T	uc003gxb.2	-	8	1127	c.975T>A	c.(973-975)CCT>CCA	p.P325P		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	325					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AAGAAACCTTAGGTAAAGACT	0.358			NA											6	38					0	0	0.004482	0	0
MUC7	4589	broad.mit.edu	37	4	71346837	71346837	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:71346837C>T	uc011cat.1	+	4	664	c.376C>T	c.(376-378)CTT>TTT	p.L126F	MUC7_uc011cau.1_Missense_Mutation_p.L126F|MUC7_uc003hfj.2_Missense_Mutation_p.L126F|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	126	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AATTACTACCCTTCCAAATGT	0.418			NA											24	101					0	0	0.00632	0	0
SLC4A4	8671	broad.mit.edu	37	4	72338512	72338512	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:72338512G>T	uc003hfy.2	+	14	1845	c.1728G>T	c.(1726-1728)TTG>TTT	p.L576F	SLC4A4_uc010iic.2_Missense_Mutation_p.L576F|SLC4A4_uc010iib.2_Missense_Mutation_p.L576F|SLC4A4_uc003hfz.2_Missense_Mutation_p.L576F|SLC4A4_uc003hgc.3_Missense_Mutation_p.L532F|SLC4A4_uc010iid.2_Intron|SLC4A4_uc003hga.2_Missense_Mutation_p.L454F|SLC4A4_uc003hgb.3_Missense_Mutation_p.L532F	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	576	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCAGCTTCTTGGTTCAATACT	0.438			NA											27	87					1.2476e-16	2.03594e-16	0.00632	1	0
PPBP	5473	broad.mit.edu	37	4	74853810	74853810	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:74853810C>A	uc003hhj.2	-	1	91	c.11G>T	c.(10-12)AGA>ATA	p.R4I		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	4					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GGTATCAAGTCTGAGGCTCAT	0.537			NA											18	76					8.04996e-18	1.34274e-17	0.012319	1	0
BMP2K	55589	broad.mit.edu	37	4	79792103	79792103	+	Silent	SNP	G	G	A	rs141745080		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:79792103G>A	uc003hlk.2	+	11	1564	c.1398G>A	c.(1396-1398)CAG>CAA	p.Q466Q	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Silent_p.Q466Q|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	466	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						agcagcagcagcagcaacagc	0.214			NA											3	32					0	0	0.009096	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86863276	86863276	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:86863276G>T	uc003hpk.2	+	5	898	c.449G>T	c.(448-450)CGT>CTT	p.R150L	ARHGAP24_uc003hpj.2_Missense_Mutation_p.R150L|ARHGAP24_uc003hpl.2_Missense_Mutation_p.R55L|ARHGAP24_uc010ikf.2_Missense_Mutation_p.R65L|ARHGAP24_uc003hpm.2_Missense_Mutation_p.R57L	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	150	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		TATGGGAACCGTCTGGCTCCG	0.453			NA											10	37					1.76689e-08	2.31765e-08	0.006214	1	0
Unknown	0	broad.mit.edu	37	4	88813075	88813075	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:88813075C>A	uc010iko.1	+	1	81	c.81C>A	c.(79-81)CTC>CTA	p.L27L						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;												NA						TCATATCCCTCATCATCAATA	0.458			NA											11	53					6.40141e-05	7.33993e-05	0.010729	1	0
ANK2	287	broad.mit.edu	37	4	114153409	114153409	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:114153409T>A	uc003ibe.3	+	5	577	c.477T>A	c.(475-477)GCT>GCA	p.A159A	ANK2_uc003ibd.3_Silent_p.A138A|ANK2_uc003ibf.3_Silent_p.A159A|ANK2_uc003ibc.2_Silent_p.A135A|ANK2_uc011cgb.1_Silent_p.A174A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	159					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAGCACTGCTACAGAGGTAA	0.383			NA											8	31					0	0	0.004482	0	0
UGT8	7368	broad.mit.edu	37	4	115544068	115544068	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:115544068T>C	uc003ibs.2	+	2	554	c.32T>C	c.(31-33)CTG>CCG	p.L11P	UGT8_uc003ibt.2_Missense_Mutation_p.L11P|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	11					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TTCATTCTCCTGTGGAGTGCT	0.403			NA											4	29					0	0	0.009096	0	0
TMEM155	132332	broad.mit.edu	37	4	122681519	122681519	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:122681519G>A	uc003idx.1	-	6	882	c.323C>T	c.(322-324)CCA>CTA	p.P108L	TMEM155_uc003idy.1_Missense_Mutation_p.P108L	NM_152399	NP_689612	Q4W5P6	TM155_HUMAN	transmembrane protein 155 precursor	108						extracellular region					0						aaaagttattgggctgctgag	0			NA											4	11					0	0	0.009096	0	0
KIAA1109	84162	broad.mit.edu	37	4	123226112	123226112	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:123226112G>A	uc003ieh.2	+	54	9691	c.9646G>A	c.(9646-9648)GCA>ACA	p.A3216T	KIAA1109_uc003iel.1_Missense_Mutation_p.A1151T	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3216					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTTAAATCTGGCATTAGGACA	0.368			NA											6	56					0	0	0.00308	0	0
NUDT6	11162	broad.mit.edu	37	4	123814181	123814181	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:123814181G>A	uc003iew.2	-	5	785	c.753C>T	c.(751-753)CTC>CTT	p.L251L	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Silent_p.L82L	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	251	Nudix hydrolase.					mitochondrion|nucleus	growth factor activity|hydrolase activity				0						CCAGGTCATTGAGATCCATCC	0.433			NA											6	92					0	0	0.001168	0	0
PCDH10	57575	broad.mit.edu	37	4	134073227	134073227	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:134073227C>A	uc003iha.2	+	1	2758	c.1932C>A	c.(1930-1932)GTC>GTA	p.V644V	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.V644V	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	644	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CACGCCGAGTCCCGGCCAAGC	0.667			NA											18	47					1.15919e-05	1.37281e-05	0.008871	1	0
NAA15	80155	broad.mit.edu	37	4	140299929	140299929	+	Silent	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:140299929A>G	uc003ihu.1	+	17	2332	c.2076A>G	c.(2074-2076)CTA>CTG	p.L692L		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	692	TPR 8.				angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						TTTTGATGCTACAATCAGTAA	0.343			NA											9	39					0	0	0.006214	0	0
FGB	2244	broad.mit.edu	37	4	155490699	155490699	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:155490699A>T	uc003ioa.3	+	7	1031	c.992A>T	c.(991-993)CAG>CTG	p.Q331L	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.Q269L|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.Q112L	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	331	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AAAATTAGCCAGCTTACCAGG	0.353	NSCLC(106;1133 1613 21870 46110 52656)		NA											13	61					0	0	0.001855	0	0
FAM198B	51313	broad.mit.edu	37	4	159091673	159091673	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:159091673G>T	uc003ipp.3	-	2	1307	c.855C>A	c.(853-855)ATC>ATA	p.I285I	uc003ipu.1_5'Flank|FAM198B_uc003ipq.3_Silent_p.I285I|FAM198B_uc003ipr.3_Silent_p.I285I|FAM198B_uc003ips.2_Silent_p.I285I|uc003ipt.1_5'Flank	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	285	Extracellular (Potential).					Golgi membrane|integral to membrane					0						TGAGCCCCAGGATCCTGTCTA	0.567			NA									OREG0016378	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	73					1.22574e-08	1.63104e-08	0.014323	1	0
ADAM29	11086	broad.mit.edu	37	4	175896699	175896699	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:175896699A>T	uc003iuc.2	+	5	693	c.23A>T	c.(22-24)CAT>CTT	p.H8L	ADAM29_uc003iud.2_Missense_Mutation_p.H8L|ADAM29_uc010irr.2_Missense_Mutation_p.H8L|ADAM29_uc011cki.1_Missense_Mutation_p.H8L	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	8					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTCCTGCTGCATTGCCTTGGG	0.493	Ovarian(140;1727 1835 21805 25838 41440)		NA											13	74					0	0	0.00499	0	0
VEGFC	7424	broad.mit.edu	37	4	177608410	177608410	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:177608410G>T	uc003ius.1	-	6	1506	c.1076C>A	c.(1075-1077)GCC>GAC	p.A359D		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	359	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|4.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		ACATTCACAGGCACATTTTCC	0.408			NA											38	145					8.20599e-20	1.39116e-19	0.011902	1	0
CEP72	55722	broad.mit.edu	37	5	640713	640713	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:640713G>T	uc003jbf.2	+	9	1605	c.1533G>T	c.(1531-1533)AAG>AAT	p.K511N		NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	511	Potential.				G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			ACACACACAAGGAGCTGGTGA	0.622			NA											11	41					1.58986e-06	1.94395e-06	0.008291	1	0
SLC6A19	340024	broad.mit.edu	37	5	1216921	1216921	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:1216921T>A	uc003jbw.3	+	8	1090	c.1034T>A	c.(1033-1035)ATC>AAC	p.I345N		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	345	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGACCCTCATCAACGGGTTC	0.657			NA											23	184					0	0	0.00278	0	0
PAPD7	11044	broad.mit.edu	37	5	6751171	6751171	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:6751171G>T	uc003jdx.1	+	11	1259	c.1130G>T	c.(1129-1131)TGC>TTC	p.C377F	PAPD7_uc011cmn.1_Missense_Mutation_p.C368F|PAPD7_uc010itl.1_Missense_Mutation_p.C197F	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	377					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						ACACCGCCCTGCACAACGCCC	0.522	NSCLC(7;212 333 5667 23379 46547)		NA											25	184					1.22384e-17	2.02912e-17	0.013726	1	0
TAS2R1	50834	broad.mit.edu	37	5	9630012	9630012	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:9630012C>A	uc003jem.1	-	1	452	c.133G>T	c.(133-135)GAT>TAT	p.D45Y		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	45	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AGAAGGAGATCCAGCGGAGCC	0.383			NA											14	86					1.45105e-14	2.26539e-14	0.006122	1	0
DAP	1611	broad.mit.edu	37	5	10681215	10681215	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:10681215T>A	uc003jez.3	-	4	469	c.262A>T	c.(262-264)AAG>TAG	p.K88*	DAP_uc011cmw.1_Silent_p.T73T	NM_004394	NP_004385	P51397	DAP1_HUMAN	death-associated protein	88					activation of caspase activity|cellular response to amino acid starvation|induction of apoptosis by extracellular signals|negative regulation of autophagy|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent		death domain binding				0		Ovarian(839;1.34e-05)|Breast(839;0.0634)|Lung NSC(810;0.0804)				GAAGGATGCTTGTCCATGGAG	0.597			NA											4	17					0	0	0.009096	0	0
CDH10	1008	broad.mit.edu	37	5	24509859	24509859	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:24509859G>T	uc003jgr.1	-	7	1404	c.1072C>A	c.(1072-1074)CGT>AGT	p.R358S	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	358	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAATAAAAACGGGGATCTACA	0.368			NA								HNSCC(23;0.051)			26	31					9.90768e-06	1.1801e-05	0.004656	1	0
CDH9	1007	broad.mit.edu	37	5	26886125	26886125	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:26886125G>T	uc003jgs.1	-	10	1749	c.1580C>A	c.(1579-1581)CCA>CAA	p.P527Q	CDH9_uc011cnv.1_Missense_Mutation_p.P120Q	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	527	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTCTGGCACTGGTTCAAAAAA	0.308	Melanoma(8;187 585 15745 40864 52829)		NA											16	182					5.26018e-13	7.98661e-13	0.012319	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33549360	33549360	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:33549360G>T	uc003jia.1	-	21	4417	c.4254C>A	c.(4252-4254)AGC>AGA	p.S1418R	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S1333R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1418	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCGGGTTACAGCTCATGCTCA	0.607			NA								HNSCC(64;0.19)			12	97					0.000219431	0.000246155	0.00245	1	0
RICTOR	253260	broad.mit.edu	37	5	39003687	39003687	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:39003687C>G	uc003jlp.2	-	4	257	c.233G>C	c.(232-234)GGC>GCC	p.G78A	RICTOR_uc003jlo.2_Missense_Mutation_p.G78A|RICTOR_uc010ivf.2_5'UTR|RICTOR_uc003jlq.1_Missense_Mutation_p.G62A|RICTOR_uc011cpk.1_Missense_Mutation_p.G78A	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	78					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					ATAGTGAAAGCCCAGTTTTTC	0.313			NA											13	112					0	0	0.004007	0	0
DAB2	1601	broad.mit.edu	37	5	39394384	39394384	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:39394384C>G	uc003jlx.2	-	2	570	c.39G>C	c.(37-39)CAG>CAC	p.Q13H	DAB2_uc003jlw.2_Missense_Mutation_p.Q13H	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	13					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GTTGGTCGGGCTGACCATTGG	0.502			NA											38	59					0	0	0.007835	0	0
NNT	23530	broad.mit.edu	37	5	43656846	43656846	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:43656846C>T	uc003joe.2	+	16	2640	c.2385C>T	c.(2383-2385)TTC>TTT	p.F795F	NNT_uc003jof.2_Silent_p.F795F	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	795	Helical; (Potential).				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	TAATCCCATTCATGGTGGACC	0.498			NA											10	144					0	0	0.008291	0	0
HCN1	348980	broad.mit.edu	37	5	45262383	45262383	+	Silent	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:45262383C>G	uc003jok.2	-	8	2338	c.2313G>C	c.(2311-2313)ACG>ACC	p.T771T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	771	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GAAGCGCCTGCGTGCTCTTGT	0.502			NA											51	53					0	0	0.01441	0	0
CENPH	64946	broad.mit.edu	37	5	68505620	68505620	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:68505620G>T	uc003jvp.2	+	9	825	c.738G>T	c.(736-738)ATG>ATT	p.M246I	CENPH_uc010ixc.2_Missense_Mutation_p.M227I	NM_022909	NP_075060	Q9H3R5	CENPH_HUMAN	centromere protein H	246					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			large_intestine(1)	1		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		ATGTTGACATGATGTAATAAG	0.353			NA											8	22					3.86212e-05	4.46541e-05	0.008291	1	0
ACOT12	134526	broad.mit.edu	37	5	80631601	80631601	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:80631601C>T	uc003khl.3	-	12	1303	c.1248G>A	c.(1246-1248)TGG>TGA	p.W416*	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	416	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AATGGGGGTCCCACAAAGGTC	0.393			NA											15	41					0	0	0.00499	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782695	115782695	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:115782695G>A	uc010jck.2	-	19	3416	c.2707C>T	c.(2707-2709)CGG>TGG	p.R903W	SEMA6A_uc003krx.3_Missense_Mutation_p.R920W|SEMA6A_uc011cwe.1_Missense_Mutation_p.R282W|SEMA6A_uc003krv.3_Missense_Mutation_p.R330W|SEMA6A_uc003krw.3_Missense_Mutation_p.R380W|SEMA6A_uc010jcj.2_Missense_Mutation_p.R447W	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	903	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		ATTTCCAGCCGCTTGCTTAGA	0.612			NA											3	65					0	0	0.009096	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324337	128324337	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:128324337G>T	uc003kuy.2	+	4	1126	c.730G>T	c.(730-732)GGT>TGT	p.G244C	SLC27A6_uc003kuz.2_Missense_Mutation_p.G244C	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	244					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GGTTTTAAGGGGTTCTGCTGT	0.368			NA											26	44					7.38237e-10	1.02e-09	0.00632	1	0
CAMLG	819	broad.mit.edu	37	5	134074471	134074471	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:134074471G>A	uc003kzt.2	+	1	266	c.161G>A	c.(160-162)GGG>GAG	p.G54E	CAMLG_uc003kzu.2_Missense_Mutation_p.G54E	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	54	Cytoplasmic (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	CACAGGCCCGGGAGCGGCGCG	0.617			NA											6	26					0	0	0.00308	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433173	140433173	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:140433173C>T	uc003lik.1	+	1	2195	c.2118C>T	c.(2116-2118)GTC>GTT	p.V706V		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	706	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTCTCTGTCATAGTGATCT	0.348			NA											7	85					0	0	0.001984	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564276	140564276	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:140564276C>T	uc003liv.2	+	1	3297	c.2142C>T	c.(2140-2142)TGC>TGT	p.C714C	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	714	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCGGCTGTGCAGGAGGAGCA	0.677			NA											35	105					0	0	0.01441	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574319	140574319	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:140574319G>T	uc003lix.2	+	1	2368	c.2194G>T	c.(2194-2196)GGT>TGT	p.G732C		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	732	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGCCCGAGGGTCCTTTTCC	0.667			NA											30	74					8.16277e-20	1.38667e-19	0.006999	1	0
RBM27	54439	broad.mit.edu	37	5	145643186	145643186	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:145643186G>C	uc003lnz.3	+	14	2489	c.2323G>C	c.(2323-2325)GAT>CAT	p.D775H	RBM27_uc003lny.2_Missense_Mutation_p.D720H	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	775					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCTGGAGAAGATTGCCAGGT	0.348			NA											10	129					0	0	0.001855	0	0
FAM114A2	10827	broad.mit.edu	37	5	153382473	153382473	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:153382473C>T	uc003lvb.2	-	10	1638	c.1050G>A	c.(1048-1050)GAG>GAA	p.E350E	FAM114A2_uc003lvc.2_Silent_p.E350E|FAM114A2_uc003lvd.2_Silent_p.E350E|FAM114A2_uc003lve.2_Silent_p.E166E|FAM114A2_uc011dda.1_Silent_p.E280E	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	350							purine nucleotide binding				0						CTTCTTCATTCTCTGCTAATG	0.373			NA											7	94					0	0	0.001984	0	0
SLIT3	6586	broad.mit.edu	37	5	168135054	168135054	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:168135054G>T	uc003mab.2	-	26	3191	c.2771C>A	c.(2770-2772)CCG>CAG	p.P924Q	SLIT3_uc010jjg.2_Missense_Mutation_p.P931Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	924	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTCTTGCACGGGCTGGAGAG	0.602	Ovarian(29;311 847 10864 17279 24903)		NA											22	77					1.1804e-14	1.86746e-14	0.003954	1	0
DOCK2	1794	broad.mit.edu	37	5	169230097	169230097	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:169230097G>T	uc003maf.2	+	26	2670	c.2590G>T	c.(2590-2592)GAG>TAG	p.E864*	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Nonsense_Mutation_p.E356*	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	864					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATCACCAAAGAGCTGAAGGA	0.438			NA											18	43					2.94398e-08	3.83134e-08	0.007413	1	0
DOCK2	1794	broad.mit.edu	37	5	169507231	169507231	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:169507231A>T	uc003maf.2	+	50	5311	c.5231A>T	c.(5230-5232)AAG>ATG	p.K1744M	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.K1236M|DOCK2_uc003mah.2_Missense_Mutation_p.K300M	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1744					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCCCCTCAAGGCGTCTGTC	0.557			NA											22	48					0	0	0.012319	0	0
FAM153B	202134	broad.mit.edu	37	5	175530281	175530281	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:175530281A>T	uc003mdk.2	+	13	773	c.716A>T	c.(715-717)GAG>GTG	p.E239V		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	239										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		GGCGAGGAGGAGGACCCAGAG	0.453			NA											24	248					0	0	0.00632	0	0
FGFR4	2264	broad.mit.edu	37	5	176520169	176520169	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:176520169C>A	uc003mfl.2	+	9	1255	c.1088C>A	c.(1087-1089)CCC>CAC	p.P363H	FGFR4_uc003mfm.2_Missense_Mutation_p.P363H|FGFR4_uc011dfu.1_Missense_Mutation_p.P363H|FGFR4_uc011dfw.1_3'UTR|FGFR4_uc003mfo.2_Intron	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	363	Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCAGCAGCGCCCGAGGCCAGG	0.662			NA								TSP Lung(9;0.080)			13	33					1.5842e-08	2.09458e-08	0.001855	1	0
ZNF354A	6940	broad.mit.edu	37	5	178154111	178154111	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:178154111C>G	uc003mjj.2	-	3	247	c.49G>C	c.(49-51)GAG>CAG	p.E17Q		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	17	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		GCCACATCCTCAAACGTCAGT	0.552			NA											12	63					0	0	0.001855	0	0
DUSP22	56940	broad.mit.edu	37	6	348210	348210	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:348210G>T	uc003msx.2	+	6	810	c.371G>T	c.(370-372)TGT>TTT	p.C124F	DUSP22_uc011dhn.1_Missense_Mutation_p.C124F|DUSP22_uc003msy.1_Missense_Mutation_p.C81F	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	124	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GGGAGATCCTGTGCCAACCCC	0.572			NA											20	162					1.28384e-07	1.62737e-07	0.012319	1	0
IRF4	3662	broad.mit.edu	37	6	401567	401567	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:401567G>T	uc003msz.3	+	7	1002	c.889G>T	c.(889-891)GAC>TAC	p.D297Y	IRF4_uc010jne.1_Missense_Mutation_p.D297Y|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.D296Y|IRF4_uc003mtc.1_Missense_Mutation_p.D127Y	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	297					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CTACCCAGAGGACAATGGCCA	0.607			NA	T	IGH@	MM 								5	50					2.7689e-08	3.60914e-08	0.001984	1	0
NEDD9	4739	broad.mit.edu	37	6	11190713	11190713	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:11190713G>A	uc003mzv.2	-	5	1556	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	NEDD9_uc010joz.2_Silent_p.L463L|NEDD9_uc003mzw.3_Silent_p.L317L	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	463					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			TGACAAAGTGGAGGTACTCCT	0.522			NA											7	26					0	0	0.00308	0	0
MYLIP	29116	broad.mit.edu	37	6	16145422	16145422	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:16145422G>A	uc003nbq.2	+	6	1359	c.1122G>A	c.(1120-1122)CTG>CTA	p.L374L	MYLIP_uc003nbr.2_Silent_p.L193L	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	374					cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			CCCGGGTGCTGCAGGAGAAGC	0.587			NA											4	94					0	0	0.009096	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056117	26056117	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:26056117C>T	uc003nfw.2	-	1	583	c.540G>A	c.(538-540)GCG>GCA	p.A180A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	180					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TCTTGGGCTTCGCAACCTTGG	0.542			NA											4	101					0	0	0.001984	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225393	26225393	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:26225393C>G	uc003nhb.2	+	2	371	c.11C>G	c.(10-12)ACT>AGT	p.T4S	HIST1H3E_uc003nhc.3_Missense_Mutation_p.T4S	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	4					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				ATGGCGCGTACTAAGCAGACG	0.532			NA											24	84					0	0	0.010818	0	0
BTN1A1	696	broad.mit.edu	37	6	26509394	26509394	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:26509394G>C	uc003nif.3	+	7	1593	c.1573G>C	c.(1573-1575)GCA>CCA	p.A525P		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	525	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						CAGCCAAGGGGCACCTTAAGG	0.517			NA											21	84					0	0	0.004656	0	0
FKSG83	83954	broad.mit.edu	37	6	27293197	27293197	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:27293197G>A	uc010jqt.2	+	1	620	c.136G>A	c.(136-138)GGT>AGT	p.G46S	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	46						integral to membrane	pheromone receptor activity				0						GTTTACTCAAGGTTTCCTCTT	0.343			NA											10	66					0	0	0.008291	0	0
ZNF165	7718	broad.mit.edu	37	6	28053504	28053504	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:28053504C>T	uc003nkg.2	+	3	1330	c.246C>T	c.(244-246)ATC>ATT	p.I82I	ZNF165_uc003nkh.2_Silent_p.I82I|ZNF165_uc003nki.3_Silent_p.I82I	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	82	SCAN box.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCAGAGATCCATACCAAGG	0.557			NA											4	37					0	0	0.000602	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571350	30571350	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:30571350G>A	uc003nqn.1	-	16	2218	c.1666C>T	c.(1666-1668)CCA>TCA	p.P556S	PPP1R10_uc010jsc.1_Missense_Mutation_p.P210S	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	556	Gly-rich.|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GCCAGAACTGGAGGCAACTTG	0.562			NA											7	162					0	0	0.001984	0	0
C6orf125	84300	broad.mit.edu	37	6	33669173	33669173	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:33669173G>A	uc003ofa.1	-	2	204	c.163C>T	c.(163-165)CAG>TAG	p.Q55*	C6orf125_uc003oez.1_5'Flank|C6orf125_uc010jve.1_RNA	NM_032340	NP_115716	Q9BRT2	CF125_HUMAN	hypothetical protein LOC84300	55											0						TCGTACATCTGATCACAGGCC	0.493			NA											4	118					0	0	0.009096	0	0
SLC26A8	116369	broad.mit.edu	37	6	35928847	35928847	+	Silent	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:35928847T>G	uc003olm.2	-	13	1602	c.1491A>C	c.(1489-1491)TCA>TCC	p.S497S	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Silent_p.S79S|SLC26A8_uc003oln.2_Silent_p.S497S|SLC26A8_uc003oll.2_Silent_p.S392S	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	497	Extracellular (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						CCAGGAAAATTGAAGATGAGA	0.393			NA											13	48					0	0	0.003163	0	0
USP49	25862	broad.mit.edu	37	6	41774562	41774562	+	Missense_Mutation	SNP	C	C	T	rs144313199		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:41774562C>T	uc003ori.2	-	4	382	c.160G>A	c.(160-162)GCC>ACC	p.A54T		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	54	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGTTTCAGGGCGTGGTCCTCA	0.577			NA											11	134					0	0	0.013537	0	0
C6orf138	442213	broad.mit.edu	37	6	48036130	48036130	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:48036130C>A	uc011dwm.1	-	1	296	c.211G>T	c.(211-213)GCC>TCC	p.A71S	C6orf138_uc011dwn.1_Intron|C6orf138_uc003ozf.2_Missense_Mutation_p.A88S	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	88						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						AGGCTGCTGGCCAGGCTGCGC	0.657			NA											14	69					4.7546e-09	6.40905e-09	0.004007	1	0
CRISP3	10321	broad.mit.edu	37	6	49704215	49704215	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:49704215G>T	uc003ozs.2	-	3	93	c.78C>A	c.(76-78)CCC>CCA	p.P26P		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	26					innate immune response	proteinaceous extracellular matrix|specific granule		p.P26P(1)		skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CAGTAAAAGCGGGATCCTAAG	0.368			NA											41	128					8.94452e-30	1.61196e-29	0.01441	1	0
TFAP2B	7021	broad.mit.edu	37	6	50810857	50810857	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:50810857G>A	uc003pag.2	+	7	1301	c.1135G>A	c.(1135-1137)GGG>AGG	p.G379R		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	379				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GACACCGATAGGGAACAGCCG	0.607	Pancreas(116;1373 2332 5475 10752)		NA											35	127					0	0	0.00623	0	0
LMBRD1	55788	broad.mit.edu	37	6	70423557	70423557	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:70423557C>A	uc003pfa.2	-	9	1010	c.895G>T	c.(895-897)GGC>TGC	p.G299C	LMBRD1_uc003pey.2_Missense_Mutation_p.G95C|LMBRD1_uc003pez.2_Missense_Mutation_p.G226C|LMBRD1_uc010kal.2_Missense_Mutation_p.G226C|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	299	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						CGCAGAGCGCCACAAAATTTT	0.393			NA											10	57					9.31168e-06	1.1107e-05	0.001855	1	0
IMPG1	3617	broad.mit.edu	37	6	76660317	76660317	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:76660317G>C	uc003pik.1	-	13	1916	c.1786C>G	c.(1786-1788)CTG>GTG	p.L596V		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	596	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CGGTACTCCAGAGAGCTCTTG	0.478	Pancreas(37;839 1141 2599 26037)		NA											4	38					0	0	0.000602	0	0
ELOVL4	6785	broad.mit.edu	37	6	80634702	80634702	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:80634702A>C	uc003pja.3	-	3	655	c.336T>G	c.(334-336)AGT>AGG	p.S112R	ELOVL4_uc011dyt.1_Intron	NM_022726	NP_073563	Q9GZR5	ELOV4_HUMAN	elongation of very long chain fatty acids-like	112					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			ovary(1)|skin(1)	2		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	AATAATCCACACTCTGGCAAA	0.308			NA											9	53					0	0	0.010729	0	0
TBX18	9096	broad.mit.edu	37	6	85446962	85446962	+	Missense_Mutation	SNP	C	C	A	rs149770046	byFrequency	TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:85446962C>A	uc003pkl.1	-	8	1265	c.1265G>T	c.(1264-1266)CGC>CTC	p.R422L	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	422					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GAGGCCTGAGCGGGCACAGGC	0.602			NA											16	76					3.99206e-14	6.16278e-14	0.007413	1	0
MDN1	23195	broad.mit.edu	37	6	90388457	90388457	+	Silent	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:90388457C>G	uc003pnn.1	-	75	12389	c.12273G>C	c.(12271-12273)GTG>GTC	p.V4091V		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4091					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CAGAGGAAATCACTTCACCTG	0.398			NA											3	53					0	0	0.009096	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577735	90577735	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:90577735G>T	uc003pnr.2	+	8	4922	c.4726G>T	c.(4726-4728)GCT>TCT	p.A1576S	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.A1576S|CASP8AP2_uc011dzz.1_Missense_Mutation_p.A1576S	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1576					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TGGAAAGGAAGCTGATGAAGG	0.393	Colon(187;1656 2025 17045 31481 39901)		NA											18	118					1.96292e-10	2.75807e-10	0.010504	1	0
FUT9	10690	broad.mit.edu	37	6	96651491	96651491	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:96651491C>A	uc003pop.3	+	3	801	c.460C>A	c.(460-462)CTG>ATG	p.L154M		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	154	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CTTGTTTAACCTGACTCTGAC	0.463	Melanoma(98;1369 1476 6592 22940 26587)		NA											10	39					7.03913e-09	9.44245e-09	0.013537	1	0
FBXL4	26235	broad.mit.edu	37	6	99322155	99322155	+	Nonstop_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:99322155C>A	uc003ppf.1	-	9	2223	c.1865G>T	c.(1864-1866)TGA>TTA	p.*622L	FBXL4_uc003ppg.1_Nonstop_Mutation_p.*622L|FBXL4_uc003pph.1_Nonstop_Mutation_p.*224L	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	622					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		TATATTAAGTCACTGAGTAAA	0.323			NA											6	30					8.12818e-05	9.20528e-05	0.001984	1	0
PRDM1	639	broad.mit.edu	37	6	106555151	106555151	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:106555151G>A	uc003prd.2	+	7	2502	c.2268G>A	c.(2266-2268)GAG>GAA	p.E756E	PRDM1_uc003pre.2_Silent_p.E622E	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	756					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CTGTAGTGGAGAAGGAAATTC	0.478			NA	D|N|Mis|F|S		DLBCL								19	55					0	0	0.010504	0	0
BEND3	57673	broad.mit.edu	37	6	107391278	107391278	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:107391278C>G	uc003prs.2	-	5	1767	c.1117G>C	c.(1117-1119)GAC>CAC	p.D373H		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	373										ovary(3)	3						TCCTCCTGGTCTTTGTTGTCC	0.642			NA											18	81					0	0	0.008871	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379204	114379204	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:114379204C>A	uc003pwg.3	-	2	290	c.258G>T	c.(256-258)CTG>CTT	p.L86L	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Silent_p.L86L	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	86	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GCTGCTGGACCAGGTCATGGA	0.577			NA											11	47					1.5842e-08	2.09458e-08	0.001855	1	0
NT5DC1	221294	broad.mit.edu	37	6	116542282	116542282	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:116542282G>T	uc003pwj.2	+	7	690	c.595G>T	c.(595-597)GAA>TAA	p.E199*	NT5DC1_uc003pwk.2_Nonsense_Mutation_p.E191*|NT5DC1_uc003pwl.2_Nonsense_Mutation_p.E149*	NM_152729	NP_689942	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase, cytosolic II-like 1 protein	199							hydrolase activity|metal ion binding				0		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		TAGTTGTCCTGAATCTGTGAA	0.323	Colon(128;1440 1664 38087 41475 42869)		NA											8	55					5.68852e-11	8.22999e-11	0.004482	1	0
GPRC6A	222545	broad.mit.edu	37	6	117128171	117128171	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:117128171C>T	uc003pxj.1	-	3	719	c.697G>A	c.(697-699)GAA>AAA	p.E233K	GPRC6A_uc003pxk.1_Missense_Mutation_p.E233K|GPRC6A_uc003pxl.1_Missense_Mutation_p.E233K	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	233	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TTATTTGCTTCAGCCTGAATT	0.403			NA											6	56					0	0	0.001168	0	0
GOPC	57120	broad.mit.edu	37	6	117896503	117896503	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:117896503C>G	uc003pxu.2	-	4	717	c.487G>C	c.(487-489)GAG>CAG	p.E163Q	GOPC_uc003pxq.1_5'Flank|GOPC_uc003pxv.2_Missense_Mutation_p.E155Q|GOPC_uc010keg.1_RNA	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	163	Potential.				apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TTGTTTGCCTCAAGCTCTCTT	0.323			NA	O	ROS1	glioblastoma								2	12					0	0	0.004672	0	0
LAMA2	3908	broad.mit.edu	37	6	129785585	129785585	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:129785585C>A	uc003qbn.2	+	49	7248	c.7143C>A	c.(7141-7143)GCC>GCA	p.A2381A	LAMA2_uc003qbo.2_Silent_p.A2381A	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2381	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGTATCTTGCCACACGAGACC	0.418			NA											24	143					9.65021e-13	1.4572e-12	0.010818	1	0
SAMD3	154075	broad.mit.edu	37	6	130465927	130465927	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:130465927A>G	uc003qbv.2	-	13	1627	c.1301T>C	c.(1300-1302)TTG>TCG	p.L434S	SAMD3_uc003qbx.2_Missense_Mutation_p.L434S|SAMD3_uc003qbw.2_Missense_Mutation_p.L434S	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	434										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TTTAACTTCCAACACAGGTGT	0.383			NA											4	22					0	0	0.009096	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349965	134349965	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:134349965G>A	uc003qem.1	-	2	1169	c.998C>T	c.(997-999)CCT>CTT	p.P333L		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	333	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		AAGAGTGGCAGGGATGGTGCT	0.502	Melanoma(122;1663 1672 14489 35294 41228)		NA											20	69					0	0	0.012319	0	0
MAP7	9053	broad.mit.edu	37	6	136704871	136704871	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:136704871T>C	uc003qgz.2	-	6	821	c.575A>G	c.(574-576)GAT>GGT	p.D192G	MAP7_uc011edf.1_Missense_Mutation_p.D177G|MAP7_uc011edg.1_Missense_Mutation_p.D214G|MAP7_uc010kgu.2_Missense_Mutation_p.D214G|MAP7_uc011edh.1_Intron|MAP7_uc010kgv.2_Missense_Mutation_p.D214G|MAP7_uc010kgs.2_Missense_Mutation_p.D46G|MAP7_uc011edi.1_Missense_Mutation_p.D46G|MAP7_uc010kgq.1_Missense_Mutation_p.D98G|MAP7_uc003qha.1_Intron|MAP7_uc010kgr.2_Missense_Mutation_p.D46G|MAP7_uc010kgt.2_Missense_Mutation_p.D214G	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	192					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AATGACGGGATCAACATATTT	0.393			NA											18	43					0	0	0.00278	0	0
KIAA1244	57221	broad.mit.edu	37	6	138576768	138576768	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:138576768C>G	uc003qhu.2	+	10	966	c.966C>G	c.(964-966)ATC>ATG	p.I322M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	322					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTCGGACTATCTATTACATCG	0.652			NA											6	53					0	0	0.001984	0	0
ECT2L	345930	broad.mit.edu	37	6	139222088	139222088	+	Silent	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:139222088C>G	uc003qif.1	+	19	2521	c.2418C>G	c.(2416-2418)CTC>CTG	p.L806L	ECT2L_uc011edq.1_Silent_p.L660L	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	806					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						AACACAGGCTCTATGAACACA	0.393			NA											4	22					0	0	0.000602	0	0
UTRN	7402	broad.mit.edu	37	6	144812227	144812227	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:144812227G>C	uc003qkt.2	+	31	4518	c.4426G>C	c.(4426-4428)GAC>CAC	p.D1476H		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1476	Spectrin 10.|Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GACGCACCTGGACAAGTGTAT	0.522			NA											14	72					0	0	0.004007	0	0
ARID1B	57492	broad.mit.edu	37	6	157528080	157528080	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:157528080G>T	uc003qqn.2	+	20	5903	c.5751G>T	c.(5749-5751)GCG>GCT	p.A1917A	ARID1B_uc003qqo.2_Silent_p.A1877A|ARID1B_uc003qqp.2_Silent_p.A1864A	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1922					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTACCATCGCGCACTGGCAGG	0.537			NA											19	112					1.2644e-06	1.55749e-06	0.010504	1	0
WIPI2	26100	broad.mit.edu	37	7	5266859	5266859	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:5266859C>T	uc003snv.2	+	10	1113	c.897C>T	c.(895-897)CTC>CTT	p.L299L	WIPI2_uc003snw.2_Silent_p.L299L|WIPI2_uc003snx.2_Silent_p.L281L|WIPI2_uc003sny.2_Silent_p.L281L|WIPI2_uc010ksv.2_Silent_p.L155L|WIPI2_uc003soa.2_Silent_p.L240L|WIPI2_uc003sob.2_Silent_p.L42L	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	299					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		GGAAAGTGCTCATGGCCTCCA	0.612			NA											10	120					0	0	0.010729	0	0
TNRC18	84629	broad.mit.edu	37	7	5355642	5355642	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:5355642C>A	uc003soi.3	-	25	7156	c.6807G>T	c.(6805-6807)ACG>ACT	p.T2269T		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2269							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGATCCTGCCCGTGTCTCCGT	0.617			NA											9	44					3.86212e-05	4.46541e-05	0.008291	1	0
FBXL18	80028	broad.mit.edu	37	7	5541559	5541559	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:5541559T>G	uc003soo.2	-	3	435	c.341A>C	c.(340-342)CAC>CCC	p.H114P	FBXL18_uc003son.3_Missense_Mutation_p.H114P	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	114	LRR 2.									central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCGGGCCACGTGTTCCACGGT	0.657			NA											10	13					0	0	0.008291	0	0
THSD7A	221981	broad.mit.edu	37	7	11521485	11521485	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:11521485G>T	uc003ssf.3	-	7	2199	c.1947C>A	c.(1945-1947)ACC>ACA	p.T649T		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	649	TSP type-1 6.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCCCTGAGCAGGTGTGTGAGC	0.567			NA								HNSCC(18;0.044)			34	91					6.2361e-21	1.07034e-20	0.007835	1	0
HDAC9	9734	broad.mit.edu	37	7	18705890	18705890	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:18705890G>T	uc003suh.2	+	11	1554	c.1513G>T	c.(1513-1515)GCA>TCA	p.A505S	HDAC9_uc003sue.2_Missense_Mutation_p.A505S|HDAC9_uc011jyd.1_Missense_Mutation_p.A505S|HDAC9_uc003sui.2_Missense_Mutation_p.A508S|HDAC9_uc003suj.2_Missense_Mutation_p.A464S|HDAC9_uc011jya.1_Missense_Mutation_p.A502S|HDAC9_uc003sua.1_Missense_Mutation_p.A483S|HDAC9_uc011jyb.1_Missense_Mutation_p.A461S|HDAC9_uc003sud.1_Missense_Mutation_p.A505S|HDAC9_uc011jyc.1_Missense_Mutation_p.A464S|HDAC9_uc003suf.1_Missense_Mutation_p.A536S|HDAC9_uc010kud.1_Missense_Mutation_p.A508S|HDAC9_uc011jye.1_Missense_Mutation_p.A477S|HDAC9_uc011jyf.1_Missense_Mutation_p.A428S|HDAC9_uc010kue.1_Intron	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	505					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTTGAGGAAGCAGAGGAAGA	0.512			NA									OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	102					1.1362e-29	2.04318e-29	0.01441	1	0
CLK2P	1197	broad.mit.edu	37	7	23625385	23625385	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:23625385G>C	uc003swk.2	-	1	762	c.112C>G	c.(112-114)CAA>GAA	p.Q38E		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						TGGTGCACTTGGTGGATGGGG	0.507			NA											4	42					0	0	0.009096	0	0
GLI3	2737	broad.mit.edu	37	7	42004379	42004379	+	Missense_Mutation	SNP	G	G	T	rs144128064		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:42004379G>T	uc011kbh.1	-	15	4383	c.4292C>A	c.(4291-4293)CCG>CAG	p.P1431Q	GLI3_uc011kbg.1_Missense_Mutation_p.P1372Q	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1431					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						AGAGCACAGCGGATGGGGCTG	0.512			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				17	132					1.5739e-10	2.24572e-10	0.004007	1	0
MRPL32	64983	broad.mit.edu	37	7	42972003	42972003	+	Silent	SNP	G	G	T	rs113789800		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:42972003G>T	uc003tia.2	+	1	65	c.18G>T	c.(16-18)CTG>CTT	p.L6L	C7orf25_uc010kxr.2_5'Flank|PSMA2_uc003thy.2_5'Flank|PSMA2_uc010kxt.2_5'Flank|PSMA2_uc003thz.1_5'Flank|MRPL32_uc003tib.2_RNA|MRPL32_uc003tic.2_5'UTR	NM_031903	NP_114109	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32 precursor	6					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome				0						TGGCCATGCTGGTCTTGGTGG	0.642			NA											19	65					7.45023e-12	1.09314e-11	0.010504	1	0
ADCY1	107	broad.mit.edu	37	7	45743283	45743283	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:45743283G>A	uc003tne.3	+	16	2674	c.2656G>A	c.(2656-2658)GGC>AGC	p.G886S		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	886	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGAGCTGGACGGCAACAACAT	0.567			NA											5	275					0	0	0.001168	0	0
EGFR	1956	broad.mit.edu	37	7	55227989	55227989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:55227989C>T	uc003tqk.2	+	12	1702	c.1456C>T	c.(1456-1458)CAG>TAG	p.Q486*	EGFR_uc003tqi.2_Nonsense_Mutation_p.Q486*|EGFR_uc003tqj.2_Nonsense_Mutation_p.Q486*|EGFR_uc010kzg.1_Nonsense_Mutation_p.Q441*|EGFR_uc011kco.1_Nonsense_Mutation_p.Q433*|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	486	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GACCTCCGGTCAGAAAACCAA	0.373			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			6	35					0	0	0.001168	0	0
NCF1B	654816	broad.mit.edu	37	7	72640002	72640002	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:72640002T>A	uc011kes.1	+	3	237	c.233T>A	c.(232-234)CTG>CAG	p.L78Q	FKBP6_uc003twz.2_Intron|NCF1B_uc011ker.1_Missense_Mutation_p.L80Q	NM_000265	NP_000256			neutrophil cytosolic factor 1												0						CTCATGAGCCTGCCCACCAAG	0.597			NA											4	26					0	0	0.001984	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72662628	72662628	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:72662628C>A	uc003txs.1	-	12	989	c.61G>T	c.(61-63)GGG>TGG	p.G21W	FKBP6_uc003twz.2_Intron	NR_002164				RecName: Full=General transcription factor II-I repeat domain-containing protein 2B; AltName: Full=GTF2I repeat domain-containing protein 2B; AltName: Full=Transcription factor GTF2IRD2-beta;												0						AGCTCAAGCCCTGGAAGCGGC	0.438			NA											27	218					1.02591e-13	1.56914e-13	0.010771	1	0
PCLO	27445	broad.mit.edu	37	7	82474737	82474737	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:82474737T>A	uc003uhx.2	-	13	14185	c.13896A>T	c.(13894-13896)TCA>TCT	p.S4632S	PCLO_uc003uhv.2_Silent_p.S4632S|PCLO_uc003uht.1_Silent_p.S83S|PCLO_uc003uhu.1_Silent_p.S62S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4520					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGCTGTAGTGAAACCTTCT	0.468			NA											6	19					0	0	0.001984	0	0
SEMA3D	223117	broad.mit.edu	37	7	84651838	84651838	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:84651838T>G	uc003uic.2	-	11	1323	c.1283A>C	c.(1282-1284)TAT>TCT	p.Y428S	SEMA3D_uc010led.2_Missense_Mutation_p.Y428S|SEMA3D_uc003uib.2_Missense_Mutation_p.Y67S	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	428	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TACGGACTTATACATCACAGA	0.428	Ovarian(63;442 1191 17318 29975 31528)		NA											25	193					0	0	0.00632	0	0
CDK6	1021	broad.mit.edu	37	7	92244469	92244469	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:92244469C>A	uc011khw.1	-	8	1378	c.966G>T	c.(964-966)GAG>GAT	p.E322D	CDK6_uc010lez.2_Missense_Mutation_p.E322D	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	322					cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CTGTATTCAGCTCCGAGGTGT	0.577			NA	T	MLLT10	ALL								12	27					1.05317e-09	1.44549e-09	0.00245	1	0
NPTX2	4885	broad.mit.edu	37	7	98249103	98249103	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:98249103C>T	uc003upl.2	+	2	752	c.575C>T	c.(574-576)TCG>TTG	p.S192L		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	192					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AATGAGACCTCGGCTCACCGG	0.652			NA											3	41					0	0	0.004672	0	0
SMURF1	57154	broad.mit.edu	37	7	98654860	98654860	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:98654860G>C	uc003upu.1	-	5	691	c.371C>G	c.(370-372)TCA>TGA	p.S124*	SMURF1_uc003upv.1_Nonsense_Mutation_p.S124*|SMURF1_uc003upt.2_Nonsense_Mutation_p.S124*	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	124					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			ATCAGTATCTGAGGGGTTTAG	0.433			NA											5	163					0	0	0.000602	0	0
MUC17	140453	broad.mit.edu	37	7	100682521	100682521	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:100682521T>A	uc003uxp.1	+	3	7877	c.7824T>A	c.(7822-7824)TCT>TCA	p.S2608S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2608	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCACCACTTCTACTGAAACCA	0.443			NA											65	415					0	0	0.01441	0	0
SH2B2	10603	broad.mit.edu	37	7	101952100	101952100	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:101952100G>C	uc011kko.1	+	4	1009	c.964G>C	c.(964-966)GAG>CAG	p.E322Q		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	279	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						TCCCCAGGTAGAGAATGGAGC	0.592			NA											12	219					0	0	0.001855	0	0
PUS7	54517	broad.mit.edu	37	7	105148818	105148818	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:105148818G>A	uc003vcx.2	-	2	361	c.142C>T	c.(142-144)CAG>TAG	p.Q48*	PUS7_uc010lji.2_Nonsense_Mutation_p.Q48*|PUS7_uc003vcy.2_Nonsense_Mutation_p.Q48*|PUS7_uc003vcz.1_Nonsense_Mutation_p.Q48*	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	48					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						AAGTCATTCTGTAGCCCATCT	0.478	Colon(138;2387 3051 17860)		NA											22	123					0	0	0.014323	0	0
GPR22	2845	broad.mit.edu	37	7	107115750	107115750	+	Silent	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:107115750C>G	uc003vef.2	+	3	2591	c.1245C>G	c.(1243-1245)ACC>ACG	p.T415T	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	415	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						AAAAAATTACCTTTGAAGATA	0.343			NA											9	31					0	0	0.006214	0	0
LAMB4	22798	broad.mit.edu	37	7	107756451	107756451	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:107756451C>A	uc010ljo.1	-	3	274	c.190G>T	c.(190-192)GAG>TAG	p.E64*	LAMB4_uc003vey.2_Nonsense_Mutation_p.E64*	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	64	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CAACCCACCTCCAGGTAACTG	0.478			NA											13	63					1.05317e-09	1.44549e-09	0.00245	1	0
CFTR	1080	broad.mit.edu	37	7	117149133	117149133	+	Silent	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:117149133T>A	uc003vjd.2	+	3	342	c.210T>A	c.(208-210)ATT>ATA	p.I70I	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	70	Cytoplasmic (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTAAACTCATTAATGCCCTTC	0.338			NA							Cystic_Fibrosis				32	77					0	0	0.00874	0	0
ING3	54556	broad.mit.edu	37	7	120606714	120606714	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:120606714G>T	uc003vjn.2	+	6	533	c.399G>T	c.(397-399)GTG>GTT	p.V133V	ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Silent_p.V133V|ING3_uc011kns.1_Silent_p.V118V	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	133					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					CACAGCCAGTGAACAATCACC	0.388			NA											41	104					3.7469e-33	6.76728e-33	0.01441	1	0
WNT16	51384	broad.mit.edu	37	7	120971841	120971841	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:120971841C>A	uc003vjw.2	+	3	713	c.456C>A	c.(454-456)ACC>ACA	p.T152T	WNT16_uc003vjv.2_Silent_p.T142T|WNT16_uc010lkl.2_Intron	NM_057168	NP_476509	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	152					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)					GTGACACCACCTTGCAGAACG	0.537			NA											17	49					6.44725e-10	8.95272e-10	0.014323	1	0
AASS	10157	broad.mit.edu	37	7	121766473	121766473	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:121766473C>A	uc003vka.2	-	3	524	c.428G>T	c.(427-429)AGA>ATA	p.R143I	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.R143I|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	143	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCGTACTCCTCTATGATCCAC	0.413			NA											47	295					1.56989e-16	2.54685e-16	0.01441	1	0
ZNF800	168850	broad.mit.edu	37	7	127014540	127014540	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:127014540G>C	uc003vlx.1	-	5	1113	c.850C>G	c.(850-852)CCA>GCA	p.P284A	ZNF800_uc003vlw.1_Missense_Mutation_p.P187A|ZNF800_uc003vly.1_Missense_Mutation_p.P284A|ZNF800_uc010lla.2_Missense_Mutation_p.P284A	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTACTTAATGGAACTAGAACA	0.358			NA											5	85					0	0	0.001168	0	0
FSCN3	29999	broad.mit.edu	37	7	127235648	127235648	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:127235648C>A	uc003vmd.1	+	2	651	c.432C>A	c.(430-432)GTC>GTA	p.V144V	FSCN3_uc003vmc.1_Silent_p.V99V|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Silent_p.V10V|FSCN3_uc010llc.1_Silent_p.V144V	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	144						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CCCTCCATGTCCACGTGATCC	0.602			NA											11	79					9.31168e-06	1.1107e-05	0.001855	1	0
CHRM2	1129	broad.mit.edu	37	7	136700977	136700977	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:136700977C>T	uc003vtf.1	+	4	1988	c.1365C>T	c.(1363-1365)CTC>CTT	p.L455L	CHRM2_uc003vtg.1_Silent_p.L455L|CHRM2_uc003vtj.1_Silent_p.L455L|CHRM2_uc003vtk.1_Silent_p.L455L|CHRM2_uc003vtl.1_Silent_p.L455L|CHRM2_uc003vtm.1_Silent_p.L455L|CHRM2_uc003vti.1_Silent_p.L455L|CHRM2_uc003vto.1_Silent_p.L455L|CHRM2_uc003vtn.1_Silent_p.L455L|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	455	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	AACACCTTCTCATGTGTCATT	0.408			NA											7	84					0	0	0.006214	0	0
DENND2A	27147	broad.mit.edu	37	7	140255507	140255507	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:140255507C>T	uc010lnj.2	-	10	2111	c.1966G>A	c.(1966-1968)GGC>AGC	p.G656S	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.G656S|DENND2A_uc003vvw.2_Missense_Mutation_p.G656S|DENND2A_uc003vvx.2_Missense_Mutation_p.G656S	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	656										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TTCCCTTTGCCTCCAGGCTTT	0.488			NA											11	48					0	0	0.001855	0	0
BRAF	673	broad.mit.edu	37	7	140481402	140481402	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:140481402C>A	uc003vwc.3	-	11	1467	c.1406G>T	c.(1405-1407)GGA>GTA	p.G469V		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	469	ATP (By similarity).|Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(12)|p.G469S(6)|p.G469R(6)|p.G469E(5)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCC	0.373	Colon(40;35 892 2973 5743 27438)	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				25	120					1.7881e-09	2.42608e-09	0.008361	1	0
TRPV5	56302	broad.mit.edu	37	7	142622697	142622697	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:142622697C>T	uc003wby.1	-	8	1313	c.1049G>A	c.(1048-1050)CGC>CAC	p.R350H	TRPV5_uc003wbz.2_Missense_Mutation_p.R350H	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	350	Extracellular (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CTTAAGGGGGCGGTAGACGCA	0.527			NA											3	112					0	0	0.004672	0	0
KEL	3792	broad.mit.edu	37	7	142639549	142639549	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:142639549T>G	uc003wcb.2	-	18	2219	c.2009A>C	c.(2008-2010)CAG>CCG	p.Q670P		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	670	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GAAGATCTGCTGGGGGCTGAG	0.577			NA											3	18					0	0	0.009096	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147815224	147815224	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:147815224G>A	uc003weu.1	+	16	2914	c.2398G>A	c.(2398-2400)GCC>ACC	p.A800T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	800	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTATTGGAATGCCGCCTCTTT	0.428			NA								HNSCC(39;0.1)			5	128					0	0	0.001984	0	0
ABCB8	11194	broad.mit.edu	37	7	150732998	150732998	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:150732998G>T	uc003wil.3	+	8	1101	c.1008G>T	c.(1006-1008)GAG>GAT	p.E336D	ABCB8_uc003wii.2_Missense_Mutation_p.E356D|ABCB8_uc003wij.3_Missense_Mutation_p.E319D|ABCB8_uc010lpw.1_Missense_Mutation_p.G185C|ABCB8_uc010lpx.2_Missense_Mutation_p.E319D|ABCB8_uc011kvd.1_Missense_Mutation_p.E231D|ABCB8_uc003wim.3_Missense_Mutation_p.E114D|ABCB8_uc003wik.3_Missense_Mutation_p.E319D	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	336	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TAGCAGACGAGGCCCTGGGCA	0.612			NA											6	55					2.7689e-08	3.60914e-08	0.001984	1	0
DPP6	1804	broad.mit.edu	37	7	154598741	154598741	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:154598741T>C	uc003wlk.2	+	16	1714	c.1585T>C	c.(1585-1587)TCC>CCC	p.S529P	DPP6_uc003wli.2_Missense_Mutation_p.S465P|DPP6_uc003wlm.2_Missense_Mutation_p.S467P|DPP6_uc011kvq.1_Missense_Mutation_p.S422P	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	529	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GCAGTGCCTCTCCTGTGACCT	0.592	NSCLC(125;1384 1783 2490 7422 34254)		NA											22	163					0	0	0.007291	0	0
DPP6	1804	broad.mit.edu	37	7	154679441	154679441	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:154679441C>A	uc003wlk.2	+	23	2430	c.2301C>A	c.(2299-2301)TAC>TAA	p.Y767*	DPP6_uc003wli.2_Nonsense_Mutation_p.Y703*|DPP6_uc003wlm.2_Nonsense_Mutation_p.Y705*|DPP6_uc011kvq.1_Nonsense_Mutation_p.Y660*	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	767	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ACAGAGCATACGAGGTGTGTA	0.582	NSCLC(125;1384 1783 2490 7422 34254)		NA											37	250					2.58029e-29	4.62999e-29	0.009718	1	0
HTR5A	3361	broad.mit.edu	37	7	154875864	154875864	+	Splice_Site	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:154875864G>T	uc003wlu.1	+	2	806	c.742_splice	c.e2-1	p.V248_splice		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A							integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTCTTTTACAGGTGAAGGACT	0.592			NA											8	19					0.000673444	0.000743389	0.008291	1	0
NOM1	64434	broad.mit.edu	37	7	156752856	156752857	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr7:156752856_156752857GG>TT	uc003wmy.2	+	4	1635_1636	c.1620_1621GG>TT	c.(1618-1623)CAGGAC>CATTAC	p.540_541QD>HY	NOM1_uc010lqp.1_5'Flank	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	540_541	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GCGAGTTTCAGGACCAGACCAG	0.47			NA											20	63					0	0	0.004672	0	0
MYOM2	9172	broad.mit.edu	37	8	2000343	2000343	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:2000343A>T	uc003wpx.3	+	3	313	c.175A>T	c.(175-177)AGC>TGC	p.S59C	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	59					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GAGAGCCTCCAGCCAGACGTC	0.572			NA											35	101					0	0	0.003755	0	0
RP1L1	94137	broad.mit.edu	37	8	10466309	10466309	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:10466309C>A	uc003wtc.2	-	4	5528	c.5299G>T	c.(5299-5301)GCA>TCA	p.A1767S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1767					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGAGCCATTGCATCTCCCTCT	0.587			NA											33	200					6.70999e-13	1.01692e-12	0.004289	1	0
RP1L1	94137	broad.mit.edu	37	8	10466530	10466530	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:10466530A>G	uc003wtc.2	-	4	5307	c.5078T>C	c.(5077-5079)CTG>CCG	p.L1693P		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1693					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTTCCTCTGCAGAATCTGCTG	0.607			NA											33	117					0	0	0.003271	0	0
TEX15	56154	broad.mit.edu	37	8	30703740	30703740	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:30703740G>A	uc003xil.2	-	1	2794	c.2794C>T	c.(2794-2796)CAT>TAT	p.H932Y		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	932										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAATCTTTATGTGGTATGTTC	0.343			NA											22	94					0	0	0.004656	0	0
PXDNL	137902	broad.mit.edu	37	8	52387622	52387622	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:52387622C>A	uc003xqu.3	-	7	705	c.604G>T	c.(604-606)GGC>TGC	p.G202C		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	202	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGGGTGTGGCCGTGTTGGGCA	0.537			NA											9	24					0.000442599	0.000490528	0.006214	1	0
MOS	4342	broad.mit.edu	37	8	57025614	57025614	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:57025614C>A	uc011leb.1	-	1	928	c.928G>T	c.(928-930)GGG>TGG	p.G310W		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	310	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			AGGCGCTGCCCGGGGAGCGAG	0.687	Esophageal Squamous(124;373 2870 4778)		NA											4	27					1.23904e-05	1.45697e-05	0.000602	1	0
CSPP1	79848	broad.mit.edu	37	8	67986491	67986491	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:67986491G>C	uc003xxi.2	+	2	143	c.112G>C	c.(112-114)GCT>CCT	p.A38P	CSPP1_uc003xxg.1_Missense_Mutation_p.A38P|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.A38P	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	38	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			CTGCAAAATGGCTGATAATTT	0.338			NA											6	60					0	0	0.001984	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70674028	70674029	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:70674028_70674029GG>TT	uc003xyl.2	-	3	1696_1697	c.989_990CC>AA	c.(988-990)CCC>CAA	p.P330Q	SLCO5A1_uc010lzb.2_Missense_Mutation_p.P330Q|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.P330Q|SLCO5A1_uc010lzc.2_Missense_Mutation_p.P330Q	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	330	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CAGGATTTCTGGGATCAACATA	0.386			NA											11	29					0	0	0.004672	0	0
PRDM14	63978	broad.mit.edu	37	8	70970913	70970913	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:70970913G>T	uc003xym.2	-	6	1550	c.1348C>A	c.(1348-1350)CAC>AAC	p.H450N		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	450	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TGAAGAATGTGGATCCGAAGC	0.517	NSCLC(129;99 1813 5906 40656 46114)		NA											12	54					1.49906e-05	1.75774e-05	0.00245	1	0
PRDM14	63978	broad.mit.edu	37	8	70978595	70978595	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:70978595C>A	uc003xym.2	-	5	1260	c.1058G>T	c.(1057-1059)TGC>TTC	p.C353F		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	353	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GATCTCTTTGCAGCTCTCATA	0.502	NSCLC(129;99 1813 5906 40656 46114)		NA											13	41					7.93312e-07	9.80113e-07	0.00245	1	0
XKR9	389668	broad.mit.edu	37	8	71619381	71619381	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:71619381C>G	uc003xyq.2	+	4	1020	c.486C>G	c.(484-486)TTC>TTG	p.F162L	XKR9_uc010lze.2_Missense_Mutation_p.F162L|XKR9_uc010lzd.2_Missense_Mutation_p.F30L	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	162						integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			AAGCGAATTTCAGTCAGTGTA	0.383			NA											3	89					0	0	0.004672	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767937	77767937	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:77767937C>A	uc003yav.2	+	10	9032	c.8645C>A	c.(8644-8646)CCG>CAG	p.P2882Q	ZFHX4_uc003yau.1_Missense_Mutation_p.P2927Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2882Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2882						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATGATCGGCCGGGTCACAAG	0.498			NA								HNSCC(33;0.089)			6	23					0.00198382	0.00215825	0.001984	1	0
NBN	4683	broad.mit.edu	37	8	90958458	90958458	+	Silent	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:90958458T>C	uc003yej.1	-	13	2090	c.1980A>G	c.(1978-1980)AGA>AGG	p.R660R	NBN_uc003yei.1_Silent_p.R578R|NBN_uc011lgb.1_Silent_p.R660R	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	660					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TCACCAGTGATCTAAATTCAG	0.323			NA						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				14	59					0	0	0.004007	0	0
RBM12B	389677	broad.mit.edu	37	8	94746577	94746577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:94746577G>A	uc003yfz.2	-	3	2255	c.2062C>T	c.(2062-2064)CAG>TAG	p.Q688*		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	688							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CATTCTCCCTGAAGAGGCCGC	0.622			NA											6	209					0	0	0.001168	0	0
SYBU	55638	broad.mit.edu	37	8	110631080	110631080	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:110631080C>A	uc003ynj.3	-	3	581	c.418G>T	c.(418-420)GTG>TTG	p.V140L	SYBU_uc003yni.3_Missense_Mutation_p.V137L|SYBU_uc003ynk.3_Missense_Mutation_p.V21L|SYBU_uc010mco.2_Missense_Mutation_p.V139L|SYBU_uc003ynl.3_Missense_Mutation_p.V139L|SYBU_uc010mcp.2_Missense_Mutation_p.V140L|SYBU_uc010mcq.2_Missense_Mutation_p.V140L|SYBU_uc003yno.3_Missense_Mutation_p.V21L|SYBU_uc010mcr.2_Missense_Mutation_p.V140L|SYBU_uc003ynm.3_Missense_Mutation_p.V139L|SYBU_uc003ynn.3_Missense_Mutation_p.V139L|SYBU_uc010mcs.2_Missense_Mutation_p.V21L|SYBU_uc010mct.2_Missense_Mutation_p.V140L|SYBU_uc010mcu.2_Missense_Mutation_p.V139L|SYBU_uc003ynp.3_Missense_Mutation_p.V72L|SYBU_uc010mcv.2_Missense_Mutation_p.V140L	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	140	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CCTGGTTTCACAAGGCCTGAC	0.418			NA											33	147					2.59497e-14	4.02099e-14	0.007835	1	0
CSMD3	114788	broad.mit.edu	37	8	113358410	113358410	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:113358410C>G	uc003ynu.2	-	41	6517	c.6358G>C	c.(6358-6360)GGT>CGT	p.G2120R	CSMD3_uc003yns.2_Missense_Mutation_p.G1322R|CSMD3_uc003ynt.2_Missense_Mutation_p.G2080R|CSMD3_uc011lhx.1_Missense_Mutation_p.G2016R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2120	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGATCACACCACTGAAGTCT	0.373			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	61					0	0	0.004482	0	0
CSMD3	114788	broad.mit.edu	37	8	113585852	113585852	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:113585852A>G	uc003ynu.2	-	24	4079	c.3920T>C	c.(3919-3921)CTA>CCA	p.L1307P	CSMD3_uc003yns.2_Missense_Mutation_p.L579P|CSMD3_uc003ynt.2_Missense_Mutation_p.L1267P|CSMD3_uc011lhx.1_Missense_Mutation_p.L1203P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1307	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAAGCACCTAGTAGATGAGT	0.333			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	68					0	0	0.00499	0	0
CSMD3	114788	broad.mit.edu	37	8	114186078	114186078	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:114186078G>A	uc003ynu.2	-	4	741	c.582C>T	c.(580-582)TTC>TTT	p.F194F	CSMD3_uc003ynt.2_Silent_p.F154F|CSMD3_uc011lhx.1_Silent_p.F194F|CSMD3_uc010mcx.1_Silent_p.F194F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	194	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCCCGACGTCGAATCTTGTGC	0.453			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	77					0	0	0.000602	0	0
WDYHV1	55093	broad.mit.edu	37	8	124448714	124448714	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:124448714C>T	uc003yqn.1	+	4	381	c.256C>T	c.(256-258)CAT>TAT	p.H86Y	WDYHV1_uc011lij.1_Missense_Mutation_p.H26Y|WDYHV1_uc003yqo.1_Intron	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	86					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						TGTTTTGCTTCATGTTTCAAG	0.368			NA											5	34					0	0	0.000602	0	0
ADCY8	114	broad.mit.edu	37	8	131916178	131916178	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:131916178G>C	uc003ytd.3	-	7	2007	c.1751C>G	c.(1750-1752)ACT>AGT	p.T584S	ADCY8_uc010mds.2_Missense_Mutation_p.T584S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	584	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AATTAAGTAAGTTTCGATATT	0.483			NA								HNSCC(32;0.087)			12	103					0	0	0.003163	0	0
ADCY8	114	broad.mit.edu	37	8	132002707	132002707	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:132002707G>T	uc003ytd.3	-	2	1298	c.1042C>A	c.(1042-1044)CAA>AAA	p.Q348K	ADCY8_uc010mds.2_Missense_Mutation_p.Q348K	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	348	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGGAAAGCTTGGCGCTGGGCC	0.517			NA								HNSCC(32;0.087)			30	138					8.16721e-17	1.34072e-16	0.010818	1	0
BOP1	23246	broad.mit.edu	37	8	145512941	145512941	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:145512941G>T	uc003zbr.1	-	2	212	c.144C>A	c.(142-144)AGC>AGA	p.S48R	HSF1_uc003zbt.3_5'Flank|HSF1_uc003zbu.3_5'Flank	NM_015201	NP_056016	Q14137	BOP1_HUMAN	block of proliferation 1	48					cell proliferation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	nucleoplasm|PeBoW complex	protein binding				0	all_cancers(97;4.06e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;2.61e-39)|all cancers(56;1.37e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.087)			CGCCAGAATCGCTGCCGGTGC	0.617			NA											13	32					9.31168e-06	1.1107e-05	0.001855	1	0
ZNF16	7564	broad.mit.edu	37	8	146157370	146157370	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr8:146157370C>A	uc003zet.2	-	4	990	c.803G>T	c.(802-804)AGC>ATC	p.S268I	ZNF16_uc003zeu.2_Missense_Mutation_p.S268I	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	268	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CCCACATTCGCTGCACTGGTA	0.458			NA											24	104					1.2476e-16	2.03594e-16	0.00632	1	0
GLDC	2731	broad.mit.edu	37	9	6540061	6540061	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:6540061G>T	uc003zkc.2	-	22	2848	c.2655C>A	c.(2653-2655)CTC>CTA	p.L885L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	885					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CATAATCCTGGAGTCTCTTGG	0.458			NA											15	82					1.45105e-14	2.26539e-14	0.006122	1	0
PTPRD	5789	broad.mit.edu	37	9	8465638	8465638	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:8465638C>G	uc003zkk.2	-	31	4253	c.3542G>C	c.(3541-3543)CGT>CCT	p.R1181P	PTPRD_uc003zkp.2_Missense_Mutation_p.R770P|PTPRD_uc003zkq.2_Missense_Mutation_p.R770P|PTPRD_uc003zkr.2_Missense_Mutation_p.R765P|PTPRD_uc003zks.2_Missense_Mutation_p.R760P|PTPRD_uc003zkl.2_Missense_Mutation_p.R1172P|PTPRD_uc003zkm.2_Missense_Mutation_p.R1168P|PTPRD_uc003zkn.2_Missense_Mutation_p.R770P|PTPRD_uc003zko.2_Missense_Mutation_p.R767P	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1181	Extracellular (Potential).	Cleavage (Probable).		R->A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178.	transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCTCCCATAACGGATGCTTCT	0.403			NA								TSP Lung(15;0.13)			14	58					0	0	0.004007	0	0
SLC24A2	25769	broad.mit.edu	37	9	19573416	19573416	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:19573416G>T	uc003zoa.1	-	6	1342	c.1280C>A	c.(1279-1281)TCC>TAC	p.S427Y	SLC24A2_uc003zob.1_Missense_Mutation_p.S410Y	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	427	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		AGCATCACTGGATGGTGTCAT	0.353			NA											20	74					1.96895e-08	2.57861e-08	0.00278	1	0
MOBKL2B	79817	broad.mit.edu	37	9	27455202	27455202	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:27455202T>A	uc003zqn.2	-	2	843	c.347A>T	c.(346-348)CAG>CTG	p.Q116L		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	MOB1, Mps One Binder kinase activator-like 2B	116							metal ion binding|protein binding			ovary(1)|pleura(1)	2		all_neural(11;9.12e-11)		Lung(218;6.54e-05)|LUSC - Lung squamous cell carcinoma(38;0.000397)		GTTCATGTACTGGGGAGCTGG	0.478			NA											3	69					0	0	0.009096	0	0
RGP1	9827	broad.mit.edu	37	9	35751401	35751401	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:35751401G>T	uc011lpf.1	+	6	767	c.626G>T	c.(625-627)CGC>CTC	p.R209L	GBA2_uc011lpb.1_5'Flank|GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.R249L	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	209										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACATCCTGCCGCAGCCTCCGT	0.532			NA											11	54					4.68919e-08	6.06449e-08	0.008291	1	0
FRMPD1	22844	broad.mit.edu	37	9	37746729	37746729	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:37746729G>C	uc004aag.1	+	16	4744	c.4700G>C	c.(4699-4701)TGT>TCT	p.C1567S	FRMPD1_uc004aah.1_Missense_Mutation_p.C1567S	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1567						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GCCGTGTTCTGTTTGACCCAG	0.607			NA											28	121					0	0	0.010818	0	0
PRUNE2	158471	broad.mit.edu	37	9	79469073	79469073	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:79469073A>T	uc010mpk.2	-	2	212	c.88T>A	c.(88-90)TGT>AGT	p.C30S	PRUNE2_uc004akn.2_Missense_Mutation_p.C30S	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	30					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TCCAAGTCACACGATTTAGGC	0.358			NA											4	45					0	0	0.000602	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609203	84609203	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:84609203G>T	uc004amn.2	+	4	3865	c.3818G>T	c.(3817-3819)AGG>ATG	p.R1273M		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1273						integral to membrane					0						CAGGAGCCCAGGGTCCCTACC	0.542			NA											12	75					1.08611e-07	1.38734e-07	0.010729	1	0
AUH	549	broad.mit.edu	37	9	93979560	93979560	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:93979560T>C	uc004arf.3	-	8	928	c.893A>G	c.(892-894)GAG>GGG	p.E298G	AUH_uc004arg.3_Missense_Mutation_p.E269G	NM_001698	NP_001689	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-Coenzyme A	298					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding				0						GGAACCTACCTCCATCCCTTG	0.303			NA											16	34					0	0	0.006122	0	0
ANKRD19	138649	broad.mit.edu	37	9	95576207	95576207	+	Missense_Mutation	SNP	G	G	A	rs41273376		TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:95576207G>A	uc011lua.1	+	3	427	c.373G>A	c.(373-375)GCC>ACC	p.A125T	ANKRD19_uc004ass.2_RNA|ANKRD19_uc004asr.3_RNA					SubName: Full=ANKRD19 protein; SubName: Full=cDNA FLJ77364, highly similar to Homo sapiens ankyrin repeat domain 19 (ANKRD19), mRNA; SubName: Full=Ankyrin repeat domain 19, isoform CRA_a;												0						GGAACATGGCGCCAATCCAAA	0.413			NA											3	45					0	0	0.000602	0	0
PTCH1	5727	broad.mit.edu	37	9	98248113	98248113	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:98248113C>G	uc004avk.3	-	3	626	c.438G>C	c.(436-438)AAG>AAC	p.K146N	PTCH1_uc010mro.2_5'UTR|PTCH1_uc010mrp.2_5'UTR|PTCH1_uc010mrq.2_5'UTR|PTCH1_uc004avl.3_5'UTR|PTCH1_uc010mrr.2_Missense_Mutation_p.K80N|PTCH1_uc004avm.3_Missense_Mutation_p.K145N|PTCH1_uc010mrt.1_RNA|PTCH1_uc010mru.1_Intron|PTCH1_uc004avo.2_Missense_Mutation_p.K80N|PTCH1_uc010mrv.1_RNA|PTCH1_uc010mrw.1_RNA	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	146	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTTCTCCAATCTTCTGGCGAG	0.403			NA							Basal_Cell_Nevus_syndrome				4	138					0	0	0.009096	0	0
BAAT	570	broad.mit.edu	37	9	104125069	104125069	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:104125069C>T	uc010mtd.2	-	4	1007	c.898G>A	c.(898-900)GAG>AAG	p.E300K	BAAT_uc004bbd.3_Missense_Mutation_p.E300K	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	300					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TGAGTTGTCTCAAAAGTGCGA	0.453			NA											9	68					0	0	0.008291	0	0
RAD23B	5887	broad.mit.edu	37	9	110074006	110074006	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:110074006A>G	uc004bde.2	+	5	908	c.541A>G	c.(541-543)ACG>GCG	p.T181A	RAD23B_uc011lwa.1_Missense_Mutation_p.T181A|RAD23B_uc011lwb.1_Missense_Mutation_p.T160A	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	181					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						TGAAGATGCAACGAGTGCACT	0.284			NA						Direct_reversal_of_damage|NER					6	28					0	0	0.004482	0	0
ASTN2	23245	broad.mit.edu	37	9	119770372	119770372	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:119770372G>T	uc004bjs.1	-	7	1691	c.1590C>A	c.(1588-1590)ACC>ACA	p.T530T	ASTN2_uc004bjr.1_Silent_p.T530T|ASTN2_uc004bjt.1_Silent_p.T479T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	530	Extracellular (Potential).|EGF-like 1.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						ATGGCTCACCGGTTTCTGGGT	0.557			NA											18	53					1.01871e-10	1.46109e-10	0.008871	1	0
TLR4	7099	broad.mit.edu	37	9	120476891	120476891	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:120476891A>C	uc004bjz.2	+	3	2776	c.2485A>C	c.(2485-2487)ACA>CCA	p.T829P	TLR4_uc004bka.2_Missense_Mutation_p.T789P|TLR4_uc004bkb.2_Missense_Mutation_p.T629P	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	829	Cytoplasmic (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AACAGTGGGTACAGGATGCAA	0.468			NA											9	77					0	0	0.008291	0	0
PTGS1	5742	broad.mit.edu	37	9	125154703	125154703	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:125154703G>T	uc004bmg.1	+	11	1815	c.1680G>T	c.(1678-1680)ACG>ACT	p.T560T	PTGS1_uc011lys.1_Silent_p.T498T|PTGS1_uc010mwb.1_Silent_p.T414T|PTGS1_uc004bmf.1_Silent_p.T523T|PTGS1_uc004bmh.1_Silent_p.T451T|PTGS1_uc011lyt.1_Silent_p.T451T	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	560					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TTGTCAAGACGGCCACACTGA	0.567			NA											19	66					2.4624e-09	3.33006e-09	0.008871	1	0
RALGPS1	9649	broad.mit.edu	37	9	129975264	129975264	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:129975264G>T	uc004bqo.1	+	17	1755	c.1488G>T	c.(1486-1488)TGG>TGT	p.W496C	RALGPS1_uc011mac.1_Missense_Mutation_p.W454C|RALGPS1_uc004bqq.3_Missense_Mutation_p.W446C	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	496	Required for stimulation of nucleotide exchange by RALA.|PH.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TCGTGGGCTGGATGGTGCAGC	0.592			NA											13	55					6.94344e-10	9.60954e-10	0.006122	1	0
BAT2L1	84726	broad.mit.edu	37	9	134360124	134360124	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:134360124A>T	uc004can.3	+	23	5567	c.5512A>T	c.(5512-5514)AGG>TGG	p.R1838W	BAT2L1_uc004cao.3_Missense_Mutation_p.R1195W|BAT2L1_uc004cap.3_5'Flank|SNORD62A_uc004caq.2_5'Flank	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1838							protein binding				0						TCACATCCAGAGGGCCATCGG	0.577			NA											33	160					0	0	0.00623	0	0
SHOX	6473	broad.mit.edu	37	X	601756	601756	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:601756C>A	uc004cph.1	+	5	1258	c.567C>A	c.(565-567)AAC>AAA	p.N189K	SHOX_uc004cpi.2_Missense_Mutation_p.N189K	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	189					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCACAGCCAACCACCTAGACG	0.582	Ovarian(95;18 1419 12424 14056 28266)		NA											11	58					6.40141e-05	7.33993e-05	0.010729	1	0
SLC25A6	293	broad.mit.edu	37	X	1505553	1505553	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:1505553C>A	uc004cpt.2	-	4	935	c.839G>T	c.(838-840)CGG>CTG	p.R280L	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	280	Helical; Name=6; (By similarity).|Solcar 3.				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CCCCATGCCCCGCAGGACGTT	0.612			NA											32	186					1.36161e-19	2.29894e-19	0.004289	1	0
NLGN4X	57502	broad.mit.edu	37	X	5810940	5810940	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:5810940T>A	uc010ndh.2	-	6	2870	c.2369A>T	c.(2368-2370)CAG>CTG	p.Q790L	NLGN4X_uc004crp.2_Missense_Mutation_p.Q810L|NLGN4X_uc004crq.2_Missense_Mutation_p.Q790L|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q827L|NLGN4X_uc004crr.2_Missense_Mutation_p.Q790L|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q790L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	790	Cytoplasmic (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GTGCAAAGGCTGCATCCCCGT	0.507			NA											14	34					0	0	0.004007	0	0
DMD	1756	broad.mit.edu	37	X	32867934	32867934	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:32867934C>A	uc004dda.1	-	3	341	c.97G>T	c.(97-99)GGG>TGG	p.G33W	DMD_uc004dcz.2_5'UTR|DMD_uc004dcy.1_Missense_Mutation_p.G29W|DMD_uc004ddb.1_Missense_Mutation_p.G25W|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.G25W|DMD_uc010ngq.1_RNA|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	33	CH 1.|Actin-binding.		Missing (in BMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCTGCTTCCCAAACTGAAAT	0.403			NA											10	29					2.17888e-05	2.54407e-05	0.006214	1	0
ZNF81	347344	broad.mit.edu	37	X	47774711	47774711	+	Silent	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:47774711G>T	uc010nhy.1	+	6	1034	c.666G>T	c.(664-666)GGG>GGT	p.G222G		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	222						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				AAACTATTGGGCATGGTCAAG	0.358			NA											17	29					1.00905e-13	1.54621e-13	0.008871	1	0
FGD1	2245	broad.mit.edu	37	X	54492140	54492140	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:54492140G>C	uc004dtg.2	-	7	2220	c.1486C>G	c.(1486-1488)CAT>GAT	p.H496D	FGD1_uc011moi.1_Missense_Mutation_p.H254D	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	496	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TGCACCTCATGGATGATGACT	0.552			NA											15	30					0	0	0.007413	0	0
ZXDA	7789	broad.mit.edu	37	X	57934461	57934461	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:57934461C>A	uc004dve.2	-	1	2607	c.2394G>T	c.(2392-2394)TTG>TTT	p.L798F		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	798					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGCTTCATACCAAAAATGAGC	0.393			NA											16	24					1.5739e-10	2.24572e-10	0.004007	1	0
MSN	4478	broad.mit.edu	37	X	64958875	64958875	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:64958875T>A	uc004dwf.2	+	12	1586	c.1388T>A	c.(1387-1389)CTG>CAG	p.L463Q		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	463					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CGTGCTGAGCTGAAGACTGCC	0.537			NA	T	ALK	ALCL								4	27					0	0	0.009096	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912661	77912661	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:77912661G>T	uc004edc.1	-	2	1553	c.1257C>A	c.(1255-1257)AAC>AAA	p.N419K		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	419							nucleic acid binding|zinc ion binding			ovary(1)	1						GCATAGGTTGGTTTTCAGCTG	0.527			NA											19	26					2.39187e-15	3.84124e-15	0.008871	1	0
Unknown	0	broad.mit.edu	37	X	80185775	80185775	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:80185775C>T	uc004eec.1	+	1	848	c.674C>T	c.(673-675)TCA>TTA	p.S225L						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;												NA						CTGACACTGTCAGCTCTTCTG	0.438			NA											4	19					0	0	0.004482	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090999	91090999	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:91090999C>A	uc004efk.1	+	1	1341	c.496C>A	c.(496-498)CCT>ACT	p.P166T	PCDH11X_uc004efl.1_Missense_Mutation_p.P166T|PCDH11X_uc004efo.1_Missense_Mutation_p.P166T|PCDH11X_uc010nmv.1_Missense_Mutation_p.P166T|PCDH11X_uc004efm.1_Missense_Mutation_p.P166T|PCDH11X_uc004efn.1_Missense_Mutation_p.P166T|PCDH11X_uc004efh.1_Missense_Mutation_p.P166T|PCDH11X_uc004efj.1_Missense_Mutation_p.P166T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	166	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGCTGTTGATCCTGACGTAGG	0.343	NSCLC(38;925 1092 2571 38200 45895)		NA											13	19					4.14922e-12	6.15331e-12	0.004007	1	0
DIAPH2	1730	broad.mit.edu	37	X	96369870	96369870	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:96369870G>A	uc004efu.3	+	21	2891	c.2495G>A	c.(2494-2496)AGA>AAA	p.R832K	DIAPH2_uc004eft.3_Missense_Mutation_p.R832K	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	832	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AGCTTTAACAGACTTTTAGAG	0.368			NA											13	11					0	0	0.001855	0	0
PAK3	5063	broad.mit.edu	37	X	110390965	110390965	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:110390965G>T	uc004epa.2	+	4	349	c.322G>T	c.(322-324)GGA>TGA	p.G108*	PAK3_uc010npt.1_Nonsense_Mutation_p.G93*|PAK3_uc010npu.1_Nonsense_Mutation_p.G93*|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Nonsense_Mutation_p.G93*|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Nonsense_Mutation_p.G129*|PAK3_uc010npw.1_Nonsense_Mutation_p.G114*	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	108	Autoregulatory region (By similarity).|Linker.|GTPase-binding (By similarity).				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						TTGTCCACAGGGAATTCCAGA	0.418			NA								TSP Lung(19;0.15)			24	18					2.12542e-12	3.18045e-12	0.00632	1	0
ZCCHC16	340595	broad.mit.edu	37	X	111698592	111698592	+	Silent	SNP	C	C	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:111698592C>T	uc004epo.1	+	3	1077	c.636C>T	c.(634-636)TGC>TGT	p.C212C		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	212							nucleic acid binding|zinc ion binding			ovary(1)	1						TCACTCAGTGCATTCAGTTGG	0.483			NA											37	49					0	0	0.005524	0	0
GRIA3	2892	broad.mit.edu	37	X	122387356	122387356	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:122387356G>T	uc004etq.3	+	4	764	c.471G>T	c.(469-471)AAG>AAT	p.K157N	GRIA3_uc004etr.3_Missense_Mutation_p.K157N|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.K141N	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	157	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GTCATTACAAGTGGGAGAAGT	0.478			NA											21	31					1.66031e-10	2.34479e-10	0.003954	1	0
SAGE1	55511	broad.mit.edu	37	X	134992256	134992256	+	Silent	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:134992256C>A	uc004ezh.2	+	15	1958	c.1791C>A	c.(1789-1791)GTC>GTA	p.V597V	SAGE1_uc010nry.1_Silent_p.V566V|SAGE1_uc011mvv.1_Silent_p.V221V	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	597										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCGATAATGTCTTCTCGACTG	0.403			NA											35	37					4.62619e-21	7.95666e-21	0.004289	1	0
GPR112	139378	broad.mit.edu	37	X	135469964	135469964	+	Silent	SNP	G	G	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:135469964G>A	uc004ezu.1	+	16	8133	c.7842G>A	c.(7840-7842)ACG>ACA	p.T2614T	GPR112_uc010nsb.1_Silent_p.T2409T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2614	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AATCACTGACGGAGAGAATTC	0.388			NA											31	56					0	0	0.010818	0	0
GPR112	139378	broad.mit.edu	37	X	135482015	135482015	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:135482015G>T	uc004ezu.1	+	21	8606	c.8315G>T	c.(8314-8316)CGA>CTA	p.R2772L	GPR112_uc010nsb.1_Missense_Mutation_p.R2567L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2772	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGCAAACTTCGAAAAGATTAT	0.318			NA											14	24					0.000219431	0.000246155	0.00245	1	0
GPR50	9248	broad.mit.edu	37	X	150348612	150348612	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:150348612C>A	uc010ntg.1	+	2	692	c.557C>A	c.(556-558)CCT>CAT	p.P186H	uc004fes.1_5'Flank|GPR50_uc011myc.1_Missense_Mutation_p.P186H	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	186	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTGAACAACCCTGTCTTCACT	0.542			NA											45	63					2.9001e-28	5.17029e-28	0.01441	1	0
GABRQ	55879	broad.mit.edu	37	X	151815612	151815612	+	Silent	SNP	G	G	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chrX:151815612G>C	uc004ffp.1	+	4	530	c.510G>C	c.(508-510)ACG>ACC	p.T170T		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	170	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATGGAACGGTGCGGTACG	0.522			NA											14	20					0	0	0.004007	0	0
RGS1	5996	broad.mit.edu	37	1	192545941	192545942	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:192545941_192545942insT	uc001gsi.1	+	3	322_323	c.256_257insT	c.(256-258)CTGfs	p.L86fs	RGS1_uc010pou.1_Frame_Shift_Ins_p.L86fs	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	86	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				GTCTCAATCTCTGGAAAAACTT	0.322			NA											11	120	---	---	---	---	NA	NA	NA	NA	NA
SHISA4	149345	broad.mit.edu	37	1	201859666	201859667	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr1:201859666_201859667insT	uc001gxa.2	+	3	421_422	c.330_331insT	c.(328-333)TCCTGTfs	p.S110fs		NM_198149	NP_937792	Q96DD7	SHSA4_HUMAN	shisa homolog 4 precursor	110_111	Cytoplasmic (Potential).					integral to membrane					0						TCCTCTGTTCCTGTTGCTACCT	0.559			NA											36	518	---	---	---	---	NA	NA	NA	NA	NA
SFMBT2	57713	broad.mit.edu	37	10	7212995	7212997	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr10:7212995_7212997delCTC	uc009xio.1	-	20	2528_2530	c.2437_2439delGAG	c.(2437-2439)GAGdel	p.E813del	SFMBT2_uc001ijn.1_In_Frame_Del_p.E813del|SFMBT2_uc010qay.1_In_Frame_Del_p.E648del	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	813					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GAACCAGTCTCTCCTCCTCCTCC	0.596			NA											7	297	---	---	---	---	NA	NA	NA	NA	NA
UBASH3B	84959	broad.mit.edu	37	11	122647758	122647759	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr11:122647758_122647759insC	uc001pyi.3	+	3	602_603	c.242_243insC	c.(241-243)TTCfs	p.F81fs		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	81						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		GGTGACCCCTTCCTGGATGACC	0.535			NA											8	111	---	---	---	---	NA	NA	NA	NA	NA
OVCH1	341350	broad.mit.edu	37	12	29617589	29617589	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr12:29617589delA	uc001rix.1	-	18	1976	c.1976delT	c.(1975-1977)CTAfs	p.L659fs		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	659	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GTCATAACTTAGTGTGTTAAA	0.453			NA											21	107	---	---	---	---	NA	NA	NA	NA	NA
C14orf39	317761	broad.mit.edu	37	14	60933712	60933712	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:60933712delC	uc001xez.3	-	10	928	c.818delG	c.(817-819)AGTfs	p.S273fs	C14orf39_uc010apo.2_5'UTR	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	273										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		AAATAATTGACTGCTTTGAGT	0.274			NA											7	22	---	---	---	---	NA	NA	NA	NA	NA
VIPAR	63894	broad.mit.edu	37	14	77919680	77919691	+	In_Frame_Del	DEL	TCATCATCGTCA	TCATCATCGTCA	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	TCATCATCGTCA	TCATCATCGTCA	-	-	TCATCATCGTCA	TCATCATCGTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr14:77919680_77919691delTCATCATCGTCA	uc001xtt.1	-	4	485_496	c.147_158delTGACGATGATGA	c.(145-159)GATGACGATGATGAC>GAC	p.49_53DDDDD>D	VIPAR_uc001xtu.1_In_Frame_Del_p.49_53DDDDD>D|VIPAR_uc010tvj.1_In_Frame_Del_p.49_53DDDDD>D|VIPAR_uc001xtv.1_In_Frame_Del_p.49_53DDDDD>D	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	49_53					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1						TCGCTCCAGGTCATCATCGTCATCATCATCCA	0.519			NA											17	487	---	---	---	---	NA	NA	NA	NA	NA
RYR3	6263	broad.mit.edu	37	15	33988537	33988538	+	Frame_Shift_Ins	INS	-	-	G			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr15:33988537_33988538insG	uc001zhi.2	+	39	6049_6050	c.5979_5980insG	c.(5977-5982)ATTGGGfs	p.I1993fs	RYR3_uc010bar.2_Frame_Shift_Ins_p.I1993fs	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1993_1994	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATGACAGCATTGGGGAGCTGCT	0.589			NA											9	95	---	---	---	---	NA	NA	NA	NA	NA
SMG1	23049	broad.mit.edu	37	16	18847728	18847730	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	TGT	TGT	-	-	TGT	TGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr16:18847728_18847730delTGT	uc002dfm.2	-	47	8092_8094	c.7729_7731delACA	c.(7729-7731)ACAdel	p.T2577del	SMG1_uc010bwb.2_In_Frame_Del_p.T2437del|SMG1_uc010bwa.2_In_Frame_Del_p.T1308del	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2577					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TTGCAAGCTGTGTTGCTTCTAAA	0.379			NA											9	46	---	---	---	---	NA	NA	NA	NA	NA
ZNF536	9745	broad.mit.edu	37	19	31025863	31025864	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:31025863_31025864delCC	uc002nsu.1	+	3	2418_2419	c.2280_2281delCC	c.(2278-2283)TTCCGGfs	p.F760fs	ZNF536_uc010edd.1_Frame_Shift_Del_p.F760fs	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	760_761	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGAAAACTTTCCGGACATCCCA	0.604			NA											19	131	---	---	---	---	NA	NA	NA	NA	NA
PRODH2	58510	broad.mit.edu	37	19	36293929	36293929	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr19:36293929delG	uc002obx.1	-	9	1299	c.1281delC	c.(1279-1281)CCCfs	p.P427fs		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	427					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGTGGCACATGGGGCCATGGC	0.602			NA											5	10	---	---	---	---	NA	NA	NA	NA	NA
PUM2	23369	broad.mit.edu	37	2	20482888	20482899	+	In_Frame_Del	DEL	GCTGCTGTTGCT	GCTGCTGTTGCT	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GCTGCTGTTGCT	GCTGCTGTTGCT	-	-	GCTGCTGTTGCT	GCTGCTGTTGCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr2:20482888_20482899delGCTGCTGTTGCT	uc002rds.1	-	11	1552_1563	c.1529_1540delAGCAACAGCAGC	c.(1528-1542)CAGCAACAGCAGCCA>CCA	p.QQQQ510del	PUM2_uc002rdt.1_In_Frame_Del_p.QQQQ510del|PUM2_uc002rdr.2_In_Frame_Del_p.QQQQ449del|PUM2_uc010yjy.1_In_Frame_Del_p.QQQQ510del|PUM2_uc002rdu.1_In_Frame_Del_p.QQQQ510del|PUM2_uc010yjz.1_In_Frame_Del_p.QQQQ449del	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	510_513					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTAGTGCTTGGCTGCTGTTGCTGCTGCTGTGG	0.476			NA											7	97	---	---	---	---	NA	NA	NA	NA	NA
NINL	22981	broad.mit.edu	37	20	25456791	25456791	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:25456791delC	uc002wux.1	-	17	3210	c.3136delG	c.(3136-3138)GAGfs	p.E1046fs	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1046	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding	p.E1046E(1)		ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						ATTTTGGTCTCCCCCTCTTCT	0.567			NA											22	98	---	---	---	---	NA	NA	NA	NA	NA
SPO11	23626	broad.mit.edu	37	20	55910890	55910890	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr20:55910890delA	uc002xye.2	+	8	764	c.671delA	c.(670-672)GAAfs	p.E224fs	SPO11_uc002xyf.2_Frame_Shift_Del_p.E186fs	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	224					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			TTAATTGTAGAAAAAGATGCA	0.308			NA						Editing_and_processing_nucleases					12	48	---	---	---	---	NA	NA	NA	NA	NA
ADSL	158	broad.mit.edu	37	22	40745905	40745905	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr22:40745905delA	uc003ayp.3	+	2	282	c.223delA	c.(223-225)AAGfs	p.K75fs	ADSL_uc003ays.3_Frame_Shift_Del_p.K75fs|ADSL_uc003ayq.3_Frame_Shift_Del_p.K75fs|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Frame_Shift_Del_p.K75fs	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	75					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						CATCGACTTCAAGATGGCAGC	0.428	Colon(4;65 130 1097 1516)		NA											15	53	---	---	---	---	NA	NA	NA	NA	NA
DGKQ	1609	broad.mit.edu	37	4	960278	960279	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:960278_960279insA	uc003gbw.2	-	12	1477_1478	c.1403_1404insT	c.(1402-1404)CTGfs	p.L468fs	DGKQ_uc010ibn.2_Frame_Shift_Ins_p.L468fs	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	468	Ras-associating.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GTAGCCGGTCCAGCAGGGGCTG	0.688	Esophageal Squamous(17;537 645 4447 26373)		NA											14	79	---	---	---	---	NA	NA	NA	NA	NA
ATOH1	474	broad.mit.edu	37	4	94750174	94750174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr4:94750174delC	uc003hta.1	+	1	97	c.97delC	c.(97-99)CCGfs	p.P33fs		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	33	Poly-Pro.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GCAACCGCCGCCGCCGCCGCA	0.667			NA											9	39	---	---	---	---	NA	NA	NA	NA	NA
CDH18	1016	broad.mit.edu	37	5	19747127	19747127	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:19747127delC	uc003jgc.2	-	3	824	c.447delG	c.(445-447)GTGfs	p.V149fs	CDH18_uc003jgd.2_Frame_Shift_Del_p.V149fs|CDH18_uc011cnm.1_Frame_Shift_Del_p.V149fs	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	149	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGATGTCTTGCACTTTGATGA	0.398			NA											54	107	---	---	---	---	NA	NA	NA	NA	NA
HMGCS1	3157	broad.mit.edu	37	5	43297103	43297103	+	Splice_Site	DEL	C	C	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr5:43297103delC	uc003jnr.3	-	5	946	c.739_splice	c.e5+1	p.E247_splice	HMGCS1_uc003jnp.3_5'Flank|HMGCS1_uc003jnq.3_Splice_Site_p.E247_splice	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1						cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						GTAAAACTTACCTTTCTGCCA	0.418			NA											20	185	---	---	---	---	NA	NA	NA	NA	NA
OR11A1	26531	broad.mit.edu	37	6	29394923	29394923	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:29394923delG	uc003nmg.2	-	1	587	c.496delC	c.(496-498)CAGfs	p.Q166fs		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AACCTCAGCTGGGCCACCAGG	0.577			NA											13	50	---	---	---	---	NA	NA	NA	NA	NA
MRAP2	112609	broad.mit.edu	37	6	84772665	84772665	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr6:84772665delT	uc003pkg.3	+	3	371	c.181delT	c.(181-183)TTTfs	p.F61fs	MRAP2_uc010kbo.2_Intron	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	61					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						GATTTTTATGTTTTTTGTGCT	0.408			NA											23	70	---	---	---	---	NA	NA	NA	NA	NA
DBH	1621	broad.mit.edu	37	9	136517382	136517384	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-69-7765-01A-11D-2167-08	TCGA-69-7765-10A-01D-2167-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0ba008c9-dc81-4721-92b2-793b2cef0ae6	2ba9f976-7e53-4ad6-b833-9f2b78225272	g.chr9:136517382_136517384delGAA	uc004cel.2	+	8	1359_1361	c.1350_1352delGAA	c.(1348-1353)TTGAAG>TTG	p.K452del		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	452	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TCCGCATGTTGAAGAAGGTCGTG	0.66			NA											7	203	---	---	---	---	NA	NA	NA	NA	NA
