Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SAMD11	148398	broad.mit.edu	37	1	877627	877627	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:877627C>A	uc001abw.1	+	9	1061	c.981C>A	c.(979-981)ACC>ACA	p.T327T	SAMD11_uc001abx.1_Silent_p.T190T	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	327						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGTGCCAGACCCCAGGTGAGG	0.741			NA											4	11					2.56e-06	2.88608e-06	0.009096	1	0
MXRA8	54587	broad.mit.edu	37	1	1290476	1290476	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:1290476C>T	uc001aew.2	-	5	566	c.535G>A	c.(535-537)GGC>AGC	p.G179S	MXRA8_uc001aex.3_Missense_Mutation_p.G179S|MXRA8_uc001aey.3_Missense_Mutation_p.G179S|MXRA8_uc010nyl.1_Missense_Mutation_p.G179S|MXRA8_uc001aez.2_Missense_Mutation_p.G78S|MXRA8_uc001afa.2_Missense_Mutation_p.G170S	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	179	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCGGGTGCGCCGCGCGCCACC	0.502			NA											8	3					0	0	0.004482	0	0
CCNL2	81669	broad.mit.edu	37	1	1325635	1325635	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:1325635C>T	uc001afi.2	-	8	1013	c.981G>A	c.(979-981)TCG>TCA	p.S327S	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Silent_p.S105S|CCNL2_uc001afg.1_Silent_p.S105S|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	327					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		GAGAGAACCCCGAGGTACCAT	0.592			NA											31	89					0	0	0.002445	0	0
Unknown	0	broad.mit.edu	37	1	1857248	1857248	+	Missense_Mutation	SNP	C	C	T	rs140276373		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:1857248C>T	uc001aik.2	-	5	926	c.76G>A	c.(76-78)GGA>AGA	p.G26R	uc001ail.2_Missense_Mutation_p.G26R					RecName: Full=Uncharacterized protein C1orf222;												NA						ACAGACTCTCCGGCAATCACA	0.622			NA											3	68					0	0	0.009096	0	0
LRRC47	57470	broad.mit.edu	37	1	3701738	3701738	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:3701738C>A	uc001akx.1	-	3	1135	c.1107G>T	c.(1105-1107)AAG>AAT	p.K369N		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	369					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CAGCCGTCCTCTTCTCACAGA	0.617			NA											38	63					3.05275e-18	4.30199e-18	0.003214	1	0
UBE4B	10277	broad.mit.edu	37	1	10197236	10197236	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:10197236G>C	uc001aqs.3	+	17	3049	c.2336G>C	c.(2335-2337)AGA>ACA	p.R779T	UBE4B_uc001aqr.3_Missense_Mutation_p.R650T|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.R234T|UBE4B_uc001aqt.1_Missense_Mutation_p.R119T	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	779					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TATATCCGCAGACTCCGGGCT	0.522			NA											28	159					0	0	0.004289	0	0
CASZ1	54897	broad.mit.edu	37	1	10713921	10713921	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:10713921C>A	uc001aro.2	-	11	2513	c.2193G>T	c.(2191-2193)CTG>CTT	p.L731L	CASZ1_uc001arp.1_Silent_p.L731L|CASZ1_uc009vmx.2_Silent_p.L755L	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCTTGCTGCTCAGGGCGGAGA	0.701			NA											33	58					1.76056e-25	2.63561e-25	0.002852	1	0
MTOR	2475	broad.mit.edu	37	1	11298459	11298459	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:11298459C>A	uc001asd.2	-	12	2123	c.2002G>T	c.(2002-2004)GAC>TAC	p.D668Y		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	668	HEAT 2.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CAAGCCTTACCAGGATCTGTT	0.507			NA											42	81					4.01344e-20	5.75221e-20	0.00361	1	0
MTOR	2475	broad.mit.edu	37	1	11300539	11300539	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:11300539T>G	uc001asd.2	-	11	1728	c.1607A>C	c.(1606-1608)CAA>CCA	p.Q536P		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	536					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TAGCCCATCTTGAATGTCCTT	0.577			NA											39	85					0	0	0.00361	0	0
VPS13D	55187	broad.mit.edu	37	1	12336868	12336868	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:12336868G>A	uc001atv.2	+	19	3364	c.3223G>A	c.(3223-3225)GAG>AAG	p.E1075K	VPS13D_uc001atw.2_Missense_Mutation_p.E1075K|VPS13D_uc001atx.2_Missense_Mutation_p.E263K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1075					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCTTACCAAAGAGCAAGAGTC	0.438			NA									OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	154					0	0	0.00632	0	0
DHRS3	9249	broad.mit.edu	37	1	12677211	12677211	+	Missense_Mutation	SNP	C	C	T	rs147390617		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:12677211C>T	uc001auc.2	-	1	610	c.143G>A	c.(142-144)AGA>AAA	p.R48K	DHRS3_uc001aub.2_5'Flank|DHRS3_uc009vnm.2_Missense_Mutation_p.R48K|DHRS3_uc001aud.3_Missense_Mutation_p.R48K	NM_004753	NP_004744	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	48					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			skin(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	CCCGATGCCTCTCCCGCCGCC	0.701			NA											15	76					0	0	0.007413	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954896	12954896	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:12954896C>T	uc001auo.2	-	3	460	c.387G>A	c.(385-387)ATG>ATA	p.M129I		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	129											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCTCTTACTCATGGCCTCTG	0.522			NA											5	110					0	0	0.001168	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001282	13001283	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:13001282_13001283GG>TT	uc001auq.2	-	3	486_487	c.400_401CC>AA	c.(400-402)CCA>AAA	p.P134K	PRAMEF5_uc001aur.2_Intron	NM_001010889	NP_001010889	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	134											0	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCTGCACTGGTGTTTTGTTC	0.505			NA											36	701					0	0	0.004672	0	0
NBPF1	55672	broad.mit.edu	37	1	16902836	16902836	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:16902836T>A	uc009vos.1	-	19	2933	c.2045A>T	c.(2044-2046)CAG>CTG	p.Q682L	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.Q140L|NBPF1_uc010oce.1_Missense_Mutation_p.Q411L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	682						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GTCCTGCCCCTGGGACTTGTC	0.577			NA											16	722					0	0	0.006122	0	0
C1QA	712	broad.mit.edu	37	1	22965874	22965875	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:22965874_22965875GG>AT	uc001bfy.2	+	3	797_798	c.712_713GG>AT	c.(712-714)GGC>ATC	p.G238I	C1QA_uc001bfz.2_Missense_Mutation_p.G238I	NM_015991	NP_057075	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	238	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CGTCTTCAGCGGCTTCCTCATC	0.589			NA											4	40					0	0	0.004672	0	0
E2F2	1870	broad.mit.edu	37	1	23845603	23845603	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:23845603G>A	uc001bhe.1	-	5	1185	c.757C>T	c.(757-759)CAG>TAG	p.Q253*		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	253	Dimerization (Potential).				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CGGATATCCTGGTAAGTCACA	0.547			NA											18	106					0	0	0.001882	0	0
TCEB3	6924	broad.mit.edu	37	1	24077613	24077613	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:24077613A>C	uc001bho.2	+	4	656	c.596A>C	c.(595-597)GAT>GCT	p.D199A		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	199					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GAGTCTTCTGATTATGGCCAT	0.493			NA									OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	131					0	0	0.00361	0	0
SEPN1	57190	broad.mit.edu	37	1	26139212	26139212	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:26139212G>A	uc010oer.1	+	12	1371	c.1316G>A	c.(1315-1317)CGA>CAA	p.R439Q	SEPN1_uc010oes.1_Missense_Mutation_p.R405Q	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	439						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GCCTTCGACCGAGCCAAGGCT	0.632			NA											8	33					0	0	0.000978	0	0
FCN3	8547	broad.mit.edu	37	1	27695848	27695848	+	Missense_Mutation	SNP	C	C	A	rs143244488		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:27695848C>A	uc001boa.2	-	8	785	c.779G>T	c.(778-780)CGA>CTA	p.R260L	MAP3K6_uc001bny.1_5'Flank|MAP3K6_uc009vsw.1_5'Flank|FCN3_uc001bob.2_Missense_Mutation_p.R249L	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	260	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GAGATTTGATCGGTAACAGGA	0.567			NA											20	124					6.21321e-17	8.58785e-17	0.00278	1	0
TMEM39B	55116	broad.mit.edu	37	1	32560511	32560511	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:32560511G>T	uc010ogv.1	+	7	1200	c.1054G>T	c.(1054-1056)GCC>TCC	p.A352S	TMEM39B_uc010ogt.1_RNA|TMEM39B_uc010ogu.1_Missense_Mutation_p.A225S|TMEM39B_uc001bue.3_Missense_Mutation_p.A353S|TMEM39B_uc001buf.3_Missense_Mutation_p.A153S|TMEM39B_uc010ogw.1_Missense_Mutation_p.A153S	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	352						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CAAGGCCGCCGCCCATCTGGG	0.622			NA											4	50					0.00909568	0.00941286	0.009096	1	0
KIAA1522	57648	broad.mit.edu	37	1	33236708	33236708	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:33236708C>G	uc001bvv.2	+	6	1887	c.1751C>G	c.(1750-1752)TCA>TGA	p.S584*	KIAA1522_uc001bvu.1_Nonsense_Mutation_p.S643*|KIAA1522_uc010ohm.1_Nonsense_Mutation_p.S595*|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	584	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGCCCCCTCAGACCGCTCT	0.622			NA											20	160					0	0	0.004656	0	0
TMEM54	113452	broad.mit.edu	37	1	33361010	33361010	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:33361010G>A	uc001bwi.1	-	5	604	c.490C>T	c.(490-492)CTA>TTA	p.L164L	TMEM54_uc001bwj.1_Silent_p.L111L|TMEM54_uc001bwk.1_Silent_p.L144L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	164	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CAGAGCACTAGGGCGATGCCC	0.647			NA											5	51					0	0	0.000602	0	0
CSMD2	114784	broad.mit.edu	37	1	34037242	34037242	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:34037242G>T	uc001bxn.1	-	52	7882	c.7853C>A	c.(7852-7854)GCC>GAC	p.A2618D	CSMD2_uc001bxm.1_Missense_Mutation_p.A2616D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2618	Sushi 16.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATCAGCTGGGCCTGGAACTG	0.547			NA											73	72					1.32003e-40	2.10081e-40	0.00361	1	0
ZMYM4	9202	broad.mit.edu	37	1	35854605	35854605	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:35854605A>G	uc001byt.2	+	14	2438	c.2358A>G	c.(2356-2358)GTA>GTG	p.V786V	ZMYM4_uc009vuu.2_Silent_p.V754V|ZMYM4_uc001byu.2_Silent_p.V462V|ZMYM4_uc009vuv.2_Silent_p.V525V	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	786	MYM-type 8.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCAAATTGGTACAGAATAATT	0.353			NA											5	137					0	0	0.001984	0	0
INPP5B	3633	broad.mit.edu	37	1	38334220	38334220	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:38334220C>G	uc001ccg.1	-	20	2348	c.2254G>C	c.(2254-2256)GAG>CAG	p.E752Q	INPP5B_uc009vvk.1_Intron|INPP5B_uc001ccf.1_Missense_Mutation_p.E588Q	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	832	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATCCAGAGCTCTTTGGGGATT	0.493			NA											15	95					0	0	0.006122	0	0
NT5C1A	84618	broad.mit.edu	37	1	40124910	40124910	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:40124910C>A	uc001cdq.1	-	6	990	c.990G>T	c.(988-990)CAG>CAT	p.Q330H		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	330					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CATGGAACATCTGGTCATCAA	0.607			NA											10	53					1.33987e-11	1.70268e-11	0.008291	1	0
RNF220	55182	broad.mit.edu	37	1	44878028	44878028	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:44878028G>T	uc001clv.1	+	2	619	c.259G>T	c.(259-261)GAT>TAT	p.D87Y	RNF220_uc001clw.1_Missense_Mutation_p.D87Y	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	87					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGCCAATCGTGATTTCCCCCC	0.498			NA											81	331					1.30168e-36	2.04898e-36	0.00361	1	0
PRDX1	5052	broad.mit.edu	37	1	45977049	45977049	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:45977049G>C	uc001cnz.2	-	5	584	c.552C>G	c.(550-552)ATC>ATG	p.I184M	PRDX1_uc001coa.2_Missense_Mutation_p.I184M|PRDX1_uc001cob.2_Missense_Mutation_p.I184M|PRDX1_uc001coc.2_Missense_Mutation_p.I184M	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	184					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					CATCAGGCTTGATGGTATCAC	0.488			NA											56	219					0	0	0.00361	0	0
POMGNT1	55624	broad.mit.edu	37	1	46655023	46655023	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:46655023C>A	uc001cpe.2	-	22	2066	c.1902G>T	c.(1900-1902)AAG>AAT	p.K634N	POMGNT1_uc010olx.1_Missense_Mutation_p.K612N|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Missense_Mutation_p.K491N|POMGNT1_uc001cpg.2_Nonsense_Mutation_p.E626*|POMGNT1_uc001cpf.2_Missense_Mutation_p.K301N	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	634	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGGGTGGCTTCTTCACTCTGG	0.532			NA											21	55					3.6726e-16	5.02803e-16	0.003954	1	0
RAD54L	8438	broad.mit.edu	37	1	46714216	46714216	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:46714216G>C	uc009vye.2	+	3	150	c.36G>C	c.(34-36)AAG>AAC	p.K12N	RAD54L_uc001cpl.2_Missense_Mutation_p.K12N	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	12					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AGCTGGCCAAGAGAAAACCTG	0.562			NA						Direct_reversal_of_damage|Homologous_recombination					7	36					0	0	0.00308	0	0
LRRC42	115353	broad.mit.edu	37	1	54427715	54427715	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:54427715G>A	uc001cwj.1	+	5	933	c.733G>A	c.(733-735)GAG>AAG	p.E245K	LRRC42_uc001cwl.1_Missense_Mutation_p.E245K|LRRC42_uc001cwk.1_Missense_Mutation_p.E245K|LRRC42_uc009vzm.1_Missense_Mutation_p.E245K	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	245	LRR 4.										0						AGGTAACCCTGAGATCACAGA	0.398			NA											11	71					0	0	0.000978	0	0
SSBP3	23648	broad.mit.edu	37	1	54722799	54722799	+	Splice_Site	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:54722799C>A	uc001cxe.2	-	7	805	c.507_splice	c.e7+1	p.Q169_splice	SSBP3_uc001cxf.2_Intron|SSBP3_uc001cxg.2_Splice_Site_p.Q142_splice	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						AGGTACAGTACCTGGTTTCCC	0.512			NA											9	14					9.31168e-06	1.03818e-05	0.001855	1	0
DAB1	1600	broad.mit.edu	37	1	57602315	57602315	+	Splice_Site	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:57602315C>A	uc001cys.1	-	6	882	c.208_splice	c.e6-1	p.G70_splice	DAB1_uc001cyt.1_Splice_Site_p.G70_splice|DAB1_uc001cyq.1_Splice_Site_p.G70_splice|DAB1_uc001cyr.1_Splice_Site_p.G70_splice|DAB1_uc009vzw.1_Splice_Site_p.G70_splice|DAB1_uc009vzx.1_Splice_Site_p.G70_splice	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1						cell differentiation|nervous system development					skin(2)|ovary(1)	3						CAACAACGCCCTGTTGAAAGG	0.413			NA											4	21					3.59834e-05	3.95073e-05	0.001168	1	0
PTGER3	5733	broad.mit.edu	37	1	71478037	71478037	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:71478037G>A	uc001dfg.1	-	2	1259	c.1028C>T	c.(1027-1029)CCT>CTT	p.P343L	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.P343L|PTGER3_uc001dfl.1_Missense_Mutation_p.P343L|PTGER3_uc009wbm.1_Missense_Mutation_p.P343L|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.P343L|PTGER3_uc009wbn.1_Missense_Mutation_p.P343L|PTGER3_uc009wbo.2_Missense_Mutation_p.P343L|PTGER3_uc001dfo.2_Missense_Mutation_p.P343L|PTGER3_uc001dfp.1_Missense_Mutation_p.P343L|PTGER3_uc001dfq.2_Missense_Mutation_p.P343L	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	343	Helical; Name=7; (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	GTAAACCCAAGGATCCAAGAT	0.463			NA											16	11					0	0	0.006122	0	0
SLC44A5	204962	broad.mit.edu	37	1	75699726	75699726	+	Silent	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:75699726T>G	uc001dgu.2	-	12	942	c.798A>C	c.(796-798)ATA>ATC	p.I266I	SLC44A5_uc001dgt.2_Silent_p.I266I|SLC44A5_uc001dgs.2_Silent_p.I224I|SLC44A5_uc001dgr.2_Silent_p.I224I|SLC44A5_uc010oqz.1_Silent_p.I305I|SLC44A5_uc010ora.1_Silent_p.I260I|SLC44A5_uc010orb.1_Silent_p.I136I	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	266	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						GGCATCCAGCTATGAACCTCA	0.393			NA											17	48					0	0	0.010504	0	0
BCAR3	8412	broad.mit.edu	37	1	94041662	94041662	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:94041662C>G	uc001dpz.2	-	8	1986	c.1711G>C	c.(1711-1713)GAA>CAA	p.E571Q	BCAR3_uc001dqa.2_Missense_Mutation_p.E571Q|BCAR3_uc001dqb.2_Missense_Mutation_p.E571Q|BCAR3_uc001dpx.3_Missense_Mutation_p.E247Q|BCAR3_uc001dpy.2_Missense_Mutation_p.E480Q|BCAR3_uc009wdm.1_Missense_Mutation_p.E247Q	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	571	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTCATCTCTTCAGAGACTCCA	0.493			NA											4	72					0	0	0.000602	0	0
ABCA4	24	broad.mit.edu	37	1	94512642	94512642	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:94512642G>T	uc001dqh.2	-	19	2855	c.2751C>A	c.(2749-2751)TTC>TTA	p.F917L	ABCA4_uc010otn.1_Missense_Mutation_p.F843L	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	917	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CACGTTCAAAGAAGGAGTCTT	0.488			NA											29	66					3.90053e-15	5.26154e-15	0.002445	1	0
OLFM3	118427	broad.mit.edu	37	1	102290757	102290757	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:102290757C>A	uc001duf.2	-	4	548	c.477G>T	c.(475-477)GTG>GTT	p.V159V	OLFM3_uc001dug.2_Silent_p.V139V|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Silent_p.V64V|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	159	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		ACTGTTCCAGCACGGGGATCA	0.443			NA											9	23					7.03913e-09	8.45533e-09	0.001368	1	0
PRMT6	55170	broad.mit.edu	37	1	107599563	107599563	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:107599563C>T	uc010ous.1	+	1	297	c.226C>T	c.(226-228)CGG>TGG	p.R76W		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	76					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		GGGTATCCTTCGGAACTGGGC	0.657			NA											14	43					0	0	0.006122	0	0
EPS8L3	79574	broad.mit.edu	37	1	110302000	110302000	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:110302000C>G	uc001dyr.1	-	5	410	c.265G>C	c.(265-267)GAC>CAC	p.D89H	EPS8L3_uc001dys.1_Missense_Mutation_p.D89H|EPS8L3_uc001dyq.1_Missense_Mutation_p.D89H|EPS8L3_uc009wfm.1_Missense_Mutation_p.D55H|EPS8L3_uc009wfn.1_Missense_Mutation_p.D55H|EPS8L3_uc009wfo.1_Missense_Mutation_p.D36H	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	89						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CGGTAAGAGTCCAGCTCCTCC	0.602			NA											20	87					0	0	0.010504	0	0
SPAG17	200162	broad.mit.edu	37	1	118574335	118574335	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:118574335G>T	uc001ehk.2	-	25	3657	c.3589C>A	c.(3589-3591)CCA>ACA	p.P1197T		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1197						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCTTCTTTTGGGTGTTCTTCT	0.358			NA											10	32					2.80697e-09	3.38784e-09	0.000978	1	0
PHGDH	26227	broad.mit.edu	37	1	120284452	120284452	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:120284452G>C	uc001ehz.2	+	10	1368	c.1141G>C	c.(1141-1143)GAG>CAG	p.E381Q	PHGDH_uc009whm.2_Missense_Mutation_p.E279Q|PHGDH_uc001eia.2_Missense_Mutation_p.E380Q|PHGDH_uc009whn.2_Intron|PHGDH_uc001eib.2_Missense_Mutation_p.E347Q|PHGDH_uc001eic.2_5'Flank	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	381					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	CCTCCTGAAAGAGGCTTCCAA	0.577			NA											12	45					0	0	0.003163	0	0
NOTCH2	4853	broad.mit.edu	37	1	120458346	120458346	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:120458346C>A	uc001eik.2	-	34	7255	c.6999G>T	c.(6997-6999)GCG>GCT	p.A2333A		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2333	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGGGGGCCCGCAACAGCTG	0.627			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				45	71					2.56175e-15	3.46024e-15	0.00361	1	0
PIAS3	10401	broad.mit.edu	37	1	145580549	145580549	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:145580549A>G	uc001eoc.1	+	7	940	c.849A>G	c.(847-849)GGA>GGG	p.G283G	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_3'UTR|PIAS3_uc001eod.1_5'UTR	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	283					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGACTGCAGGAACCCTTCTAC	0.522			NA											15	74					0	0	0.010504	0	0
GPR89A	653519	broad.mit.edu	37	1	145826927	145826927	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:145826927C>G	uc001eot.2	-	1	177	c.3G>C	c.(1-3)ATG>ATC	p.M1I	NBPF10_uc001emp.3_Intron|GPR89A_uc010ozb.1_5'Flank|GPR89A_uc001eos.2_5'UTR|GPR89A_uc010ozc.1_5'UTR|GPR89A_uc010ozd.1_5'UTR|GPR89A_uc010oze.1_Missense_Mutation_p.M1I	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	1					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TGAGGAAACTCATGGCGAAGT	0.642			NA											8	57					0	0	0.000978	0	0
HRNR	388697	broad.mit.edu	37	1	152188343	152188343	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:152188343G>A	uc001ezt.1	-	3	5838	c.5762C>T	c.(5761-5763)TCC>TTC	p.S1921F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1921	21.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCATAGCTGGAAGATGAACC	0.577			NA											78	814					0	0	0.00361	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122394	153122394	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:153122394G>T	uc009wod.1	-	2	314	c.193C>A	c.(193-195)CAG>AAG	p.Q65K		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	65					keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TACTTCTGCTGGCAGGGTGGG	0.527			NA											26	74					9.90768e-06	1.10341e-05	0.004656	1	0
CRTC2	200186	broad.mit.edu	37	1	153924717	153924717	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:153924717C>A	uc010ped.1	-	10	844	c.774G>T	c.(772-774)CAG>CAT	p.Q258H	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	258					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CATTGGCAGGCTGGTCAGGAG	0.577			NA											43	54					8.00217e-19	1.13242e-18	0.00361	1	0
HAX1	10456	broad.mit.edu	37	1	154247910	154247910	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:154247910G>T	uc001fes.2	+	6	866	c.705G>T	c.(703-705)CGG>CGT	p.R235R	HAX1_uc001fet.2_Silent_p.R187R|HAX1_uc010peo.1_Silent_p.R243R|HAX1_uc009wou.2_Silent_p.R160R|HAX1_uc009wov.2_Silent_p.R209R	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	235	Involved in PKD2 binding.|Involved in ATP2A2 binding.|Involved in HCLS1 binding.|Involved in GNA13 binding.|Required for localization in sarcoplasmic reticulum (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTGAGGGCCGGACAGAGACTA	0.493			NA							Kostmann_syndrome				43	135					3.7469e-33	5.80741e-33	0.00361	1	0
C1orf182	128229	broad.mit.edu	37	1	156316642	156316642	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:156316642C>G	uc001foo.2	+	4	609	c.247C>G	c.(247-249)CAG>GAG	p.Q83E	C1orf182_uc009wry.2_Missense_Mutation_p.Q83E|C1orf182_uc001fop.3_Missense_Mutation_p.Q83E	NM_144627	NP_653228	Q96A04	CA182_HUMAN	SSTK-interacting protein	83											0	Hepatocellular(266;0.158)					CGCCCAACAACAGATGGCTGT	0.488			NA											11	207					0	0	0.003163	0	0
C1orf61	10485	broad.mit.edu	37	1	156386590	156386590	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:156386590G>T	uc001fou.1	-	3	159	c.42C>A	c.(40-42)AAC>AAA	p.N14K	C1orf61_uc001fov.1_Intron|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_Intron|C1orf61_uc001foy.1_Intron	NM_006365	NP_006356	Q13536	CROC4_HUMAN	transcriptional activator of the c-fos promoter	14						nucleus				skin(1)	1	Hepatocellular(266;0.158)					AAAGGAGGAAGTTCCTCAAGT	0.463			NA											61	93					2.40655e-23	3.55522e-23	0.00361	1	0
IQGAP3	128239	broad.mit.edu	37	1	156507059	156507059	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:156507059C>G	uc001fpf.2	-	27	3411	c.3336G>C	c.(3334-3336)CAG>CAC	p.Q1112H		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1112	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCAGTCGTCTCTGGACCTCGG	0.552			NA											9	70					0	0	0.004482	0	0
INSRR	3645	broad.mit.edu	37	1	156815791	156815791	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:156815791C>A	uc010pht.1	-	9	2185	c.1931G>T	c.(1930-1932)CGG>CTG	p.R644L	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	644	Fibronectin type-III 2.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTCTGCCAGCCGCTGCCACAG	0.677			NA											24	31					7.41945e-09	8.90158e-09	0.005443	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156914953	156914953	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:156914953C>A	uc001fqo.2	-	29	3769	c.2729G>T	c.(2728-2730)CGG>CTG	p.R910L	ARHGEF11_uc010phu.1_Missense_Mutation_p.R326L|ARHGEF11_uc001fqn.2_Missense_Mutation_p.R950L	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	910	DH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCACTGGTCCCGGGCCCGGCA	0.562			NA											43	77					2.17126e-26	3.27474e-26	0.00361	1	0
KIRREL	55243	broad.mit.edu	37	1	158045998	158045998	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:158045998A>T	uc001frn.3	+	2	552	c.148A>T	c.(148-150)ATT>TTT	p.I50F	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_5'UTR	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	50	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CTACTCTGGAATTGTGCAATG	0.637			NA											34	93					0	0	0.006999	0	0
MNDA	4332	broad.mit.edu	37	1	158817648	158817648	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:158817648A>C	uc001fsz.1	+	6	1318	c.1118A>C	c.(1117-1119)CAA>CCA	p.Q373P		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	373	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TTCTGCCTTCAACTGAGAACA	0.443			NA											6	143					0	0	0.001984	0	0
NCSTN	23385	broad.mit.edu	37	1	160324062	160324062	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:160324062C>T	uc001fvx.2	+	11	1458	c.1334C>T	c.(1333-1335)TCT>TTT	p.S445F	NCSTN_uc001fvy.2_Missense_Mutation_p.S425F|NCSTN_uc010pjf.1_Missense_Mutation_p.S307F|NCSTN_uc001fvz.2_Missense_Mutation_p.S225F|NCSTN_uc010pjg.1_Missense_Mutation_p.S187F	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	445	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTGACCACTCTGGTGCCTTC	0.532			NA											18	114					0	0	0.002299	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161168182	161168182	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:161168182G>T	uc001fyt.3	-	1	664	c.236C>A	c.(235-237)GCC>GAC	p.A79D	ADAMTS4_uc001fyu.2_Missense_Mutation_p.A79D|NDUFS2_uc001fyv.2_5'Flank	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	79					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAACAGCCTGGCAGGGGCGCC	0.677			NA											10	8					6.40141e-05	6.99029e-05	0.000978	1	0
UHMK1	127933	broad.mit.edu	37	1	162470701	162470701	+	Splice_Site	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:162470701A>T	uc001gcc.1	+	3	698	c.562_splice	c.e3-2	p.D188_splice	UHMK1_uc001gcb.1_Splice_Site_p.D114_splice|UHMK1_uc009wuu.1_Splice_Site_p.D188_splice	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin						cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CATCTTTTTTAGGATGTAAAG	0.423			NA											23	28					0	0	0.003954	0	0
DDR2	4921	broad.mit.edu	37	1	162740159	162740159	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:162740159T>A	uc001gcf.2	+	13	1826	c.1361T>A	c.(1360-1362)TTC>TAC	p.F454Y	DDR2_uc001gcg.2_Missense_Mutation_p.F454Y	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	454	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCTAGCATGTTCAACAATAAC	0.512	NSCLC(161;314 2006 8283 19651 23192)		NA											87	111					0	0	0.00361	0	0
C1orf110	339512	broad.mit.edu	37	1	162825131	162825131	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:162825131C>A	uc001gck.2	-	4	508	c.333G>T	c.(331-333)ATG>ATT	p.M111I	C1orf110_uc009wuw.1_Intron|C1orf110_uc009wux.1_Missense_Mutation_p.M110I	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	111											0						TGTCTTGGGCCATACGGGTTG	0.443			NA											73	121					1.55023e-36	2.43642e-36	0.00361	1	0
TADA1	117143	broad.mit.edu	37	1	166839042	166839042	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:166839042C>T	uc001gdw.2	-	2	308	c.124G>A	c.(124-126)GAG>AAG	p.E42K	TADA1_uc009wve.2_Missense_Mutation_p.E42K	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	42					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						AGGTCAAACTCCTCTTTGCTG	0.383			NA											34	135					0	0	0.002522	0	0
ADCY10	55811	broad.mit.edu	37	1	167865910	167865910	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:167865910G>T	uc001ger.2	-	7	960	c.662C>A	c.(661-663)CCC>CAC	p.P221H	ADCY10_uc009wvk.2_Missense_Mutation_p.P129H|ADCY10_uc010plj.1_Missense_Mutation_p.P68H|ADCY10_uc009wvl.2_Missense_Mutation_p.P220H|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	221					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAAATTGGGGGGTGGTTTTAA	0.328			NA											103	95					2.66069e-56	4.34407e-56	0.00361	1	0
ASTN1	460	broad.mit.edu	37	1	176905466	176905466	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:176905466C>A	uc001glc.2	-	15	2630	c.2418G>T	c.(2416-2418)CTG>CTT	p.L806L	ASTN1_uc001glb.1_Silent_p.L806L|ASTN1_uc001gld.1_Silent_p.L806L|ASTN1_uc009wwx.1_Silent_p.L806L	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	814					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCAGTGCTGCAGCACAGGGT	0.498			NA											32	61					7.61001e-30	1.16341e-29	0.005524	1	0
RASAL2	9462	broad.mit.edu	37	1	178414696	178414696	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:178414696G>T	uc001glr.2	+	7	1207	c.1082G>T	c.(1081-1083)GGA>GTA	p.G361V	RASAL2_uc001glq.2_Missense_Mutation_p.G509V	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	361	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GATCGTTGTGGAGAGCATGAT	0.413			NA											44	109					7.34454e-26	1.10442e-25	0.00361	1	0
ANGPTL1	9068	broad.mit.edu	37	1	178834850	178834850	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:178834850C>A	uc001gma.2	-	3	538	c.62G>T	c.(61-63)TGC>TTC	p.C21F	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Missense_Mutation_p.C21F|ANGPTL1_uc010pnc.1_5'UTR	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	21						extracellular space	receptor binding				0						TCCACCTCTGCAATGTCCAGT	0.383			NA											10	97					1.61879e-10	2.01649e-10	0.001368	1	0
C1orf125	126859	broad.mit.edu	37	1	179460858	179460858	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:179460858C>A	uc001gmo.2	+	19	2404	c.2277C>A	c.(2275-2277)TCC>TCA	p.S759S	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Silent_p.S759S|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	759											0						ACCAATACTCCAGCTATTTGA	0.413			NA											46	130					2.17126e-26	3.27474e-26	0.00361	1	0
CACNA1E	777	broad.mit.edu	37	1	181767606	181767606	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:181767606C>G	uc001gow.2	+	47	6614	c.6449C>G	c.(6448-6450)TCC>TGC	p.S2150C	CACNA1E_uc009wxs.2_Missense_Mutation_p.S2038C|CACNA1E_uc009wxt.2_Missense_Mutation_p.S1419C	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2193	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAGGAGGGCTCCCCGCTGACC	0.647			NA											11	60					0	0	0.008291	0	0
GLUL	2752	broad.mit.edu	37	1	182353781	182353781	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:182353781A>G	uc001gpa.1	-	7	1093	c.881T>C	c.(880-882)CTG>CCG	p.L294P	GLUL_uc010pnt.1_Missense_Mutation_p.L81P|GLUL_uc001gpb.1_Missense_Mutation_p.L294P|GLUL_uc001gpc.1_Missense_Mutation_p.L294P|GLUL_uc001gpd.1_Missense_Mutation_p.L294P	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	294					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	GGCATTGTCCAGGCCTCCCTT	0.522			NA											29	72					0	0	0.005524	0	0
NCF2	4688	broad.mit.edu	37	1	183529285	183529285	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:183529285G>C	uc001gqj.3	-	14	1689	c.1414C>G	c.(1414-1416)CAA>GAA	p.Q472E	NCF2_uc010pod.1_Missense_Mutation_p.Q427E|NCF2_uc010poe.1_Missense_Mutation_p.Q391E|NCF2_uc001gqk.3_Missense_Mutation_p.Q472E	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	472	SH3 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						TCCTCTGGTTGGGTAGCCTCA	0.438			NA											19	156					0	0	0.002299	0	0
GLT25D2	23127	broad.mit.edu	37	1	183913414	183913414	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:183913414T>A	uc001gqr.2	-	10	1685	c.1313A>T	c.(1312-1314)GAT>GTT	p.D438V	GLT25D2_uc010poj.1_Missense_Mutation_p.D438V|GLT25D2_uc001gqp.2_Missense_Mutation_p.D46V|GLT25D2_uc001gqq.2_Missense_Mutation_p.D175V|GLT25D2_uc001gqs.2_Missense_Mutation_p.D318V	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	438					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						AAAACGCACATCGTCTTCAAT	0.403	Esophageal Squamous(10;42 606 18489 38825)		NA											27	44					0	0	0.009535	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186908349	186908349	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:186908349C>A	uc001gsc.2	+	9	1110	c.905C>A	c.(904-906)ACA>AAA	p.T302K	PLA2G4A_uc010pos.1_Missense_Mutation_p.T242K	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	302	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATAGGAGAAACACTAATTCAT	0.274			NA											18	26					1.56452e-12	2.0161e-12	0.007413	1	0
RGS18	64407	broad.mit.edu	37	1	192127878	192127878	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:192127878C>A	uc001gsg.2	+	1	287	c.111C>A	c.(109-111)GCC>GCA	p.A37A		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	37					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						GCAAAGAAGCCAAAATCAGGT	0.289			NA											21	39					6.32553e-13	8.21423e-13	0.004656	1	0
RGS2	5997	broad.mit.edu	37	1	192780233	192780233	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:192780233A>G	uc001gsl.2	+	4	430	c.397A>G	c.(397-399)AGG>GGG	p.R133G		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	133	RGS.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						CTCAAAAGCAAGGAAAATATA	0.363	Pancreas(71;51 2183 4981)		NA											30	79					0	0	0.004878	0	0
CFH	3075	broad.mit.edu	37	1	196716404	196716404	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:196716404G>T	uc001gtj.3	+	22	3897	c.3657G>T	c.(3655-3657)TGG>TGT	p.W1219C		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1219	Sushi 20.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CAACATGTTGGGATGGGAAAC	0.368			NA											46	64					1.60673e-49	2.5939e-49	0.00361	1	0
ELF3	1999	broad.mit.edu	37	1	201981192	201981192	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:201981192G>A	uc001gxg.3	+	2	3463	c.271G>A	c.(271-273)GAC>AAC	p.D91N	ELF3_uc001gxi.3_Missense_Mutation_p.D91N|ELF3_uc001gxh.3_Missense_Mutation_p.D91N	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	91	PNT.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						AAGCGCCATTGACTTCTCACG	0.577			NA											25	89					0	0	0.00632	0	0
SYT2	127833	broad.mit.edu	37	1	202571541	202571541	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:202571541G>T	uc001gye.2	-	5	791	c.598C>A	c.(598-600)CTG>ATG	p.L200M	SYT2_uc010pqb.1_Missense_Mutation_p.L200M|SYT2_uc009xaf.2_Missense_Mutation_p.L30M	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	200	Phospholipid binding (By similarity).|C2 1.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GCAGGGTTCAGTGTCTTCCGA	0.522			NA											51	114					3.21867e-24	4.77594e-24	0.00361	1	0
ATP2B4	493	broad.mit.edu	37	1	203669355	203669355	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:203669355G>A	uc001gzw.2	+	5	1555	c.671G>A	c.(670-672)GGA>GAA	p.G224E	ATP2B4_uc001gzv.2_Missense_Mutation_p.G224E|ATP2B4_uc009xaq.2_Missense_Mutation_p.G224E	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	224	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGCAGATGGAATCCTGATC	0.512			NA											7	148					0	0	0.001984	0	0
CNTN2	6900	broad.mit.edu	37	1	205042860	205042860	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:205042860G>A	uc001hbr.2	+	23	3359	c.3090G>A	c.(3088-3090)GCG>GCA	p.A1030A	CNTN2_uc001hbs.2_Silent_p.A818A	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	1030					axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACTCCGTGGCGATGCTGATCC	0.622	Melanoma(183;2548 2817 37099 41192)		NA											10	54					0	0	0.001855	0	0
TMCC2	9911	broad.mit.edu	37	1	205197741	205197741	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:205197741G>A	uc001hbz.1	+	2	493	c.49G>A	c.(49-51)GAT>AAT	p.D17N	TMCC2_uc010prf.1_5'Flank	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	17						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGGCGAGGAGGATGGAGCTGG	0.647			NA											23	48					0	0	0.002096	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779211	205779211	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:205779211A>G	uc001hdh.1	-	2	1231	c.359T>C	c.(358-360)TTG>TCG	p.L120S		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	120	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			CACGATGTCCAACACCATGCC	0.582			NA											13	53					0	0	0.001368	0	0
CTSE	1510	broad.mit.edu	37	1	206317609	206317610	+	Silent	DNP	CC	CC	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:206317609_206317610CC>TT	uc001hdu.2	+	1	151_152	c.33_34CC>TT	c.(31-36)CTCCTG>CTTTTG	p.11_12LL>LL	CTSE_uc001hdv.2_Silent_p.11_12LL>LL|CTSE_uc010prs.1_5'UTR	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	11_12					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			TGCTGGTGCTCCTGGAGCTGGG	0.599			NA											17	55					0	0	0.004672	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213277908	213277908	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:213277908C>T	uc010ptr.1	+	4	534	c.375C>T	c.(373-375)TTC>TTT	p.F125F	RPS6KC1_uc001hkd.2_Silent_p.F113F|RPS6KC1_uc010pts.1_5'UTR|RPS6KC1_uc010ptt.1_5'UTR|RPS6KC1_uc010ptu.1_5'UTR|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc001hke.2_5'UTR	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	125	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AAGACTTTTTCAAGGTTTGGT	0.303			NA											11	65					0	0	0.000978	0	0
USH2A	7399	broad.mit.edu	37	1	216173749	216173749	+	Missense_Mutation	SNP	T	T	C	rs146282882	by1000genomes	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:216173749T>C	uc001hku.1	-	33	6868	c.6481A>G	c.(6481-6483)ATA>GTA	p.I2161V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2161	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTTACTGTATGTGTATAGTT	0.433			NA								HNSCC(13;0.011)			8	85					0	0	0.008291	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717462	222717462	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:222717462C>A	uc001hnh.1	-	2	449	c.391G>T	c.(391-393)GGC>TGC	p.G131C		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	131					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GAGCAGAGGCCCGGGAGATTC	0.582			NA											77	179					4.21773e-46	6.75507e-46	0.00361	1	0
TLR5	7100	broad.mit.edu	37	1	223283956	223283956	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:223283956G>A	uc001hnv.1	-	4	2864	c.2418C>T	c.(2416-2418)ATC>ATT	p.I806I	TLR5_uc001hnw.1_Silent_p.I806I	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	806	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CAAAGCCTCTGATGGATTGAT	0.458			NA											24	29					0	0	0.004656	0	0
GJC2	57165	broad.mit.edu	37	1	228346354	228346354	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:228346354C>A	uc001hsk.2	+	2	1070	c.895C>A	c.(895-897)CGC>AGC	p.R299S		NM_020435	NP_065168	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	299	Cytoplasmic (Potential).				cell death	connexon complex|integral to membrane					0		Prostate(94;0.0405)				GGACGCGGTGCGCGGCCGCCG	0.572			NA											9	4					0.000274275	0.000295982	0.004482	1	0
RYR2	6262	broad.mit.edu	37	1	237777705	237777705	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:237777705A>T	uc001hyl.1	+	37	5397	c.5277A>T	c.(5275-5277)CCA>CCT	p.P1759P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1759	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCCTCAGGCCACGGATGCAGT	0.512			NA											13	29					0	0	0.004007	0	0
RYR2	6262	broad.mit.edu	37	1	237817625	237817625	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:237817625G>C	uc001hyl.1	+	52	7996	c.7876G>C	c.(7876-7878)GGG>CGG	p.G2626R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2626	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTGCCTGGAGGGTGGGGAAA	0.383			NA											24	44					0	0	0.008361	0	0
ZP4	57829	broad.mit.edu	37	1	238046086	238046086	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:238046086G>T	uc001hym.2	-	11	1451	c.1451C>A	c.(1450-1452)CCC>CAC	p.P484H	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	484	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAGAATCATGGGGCCTTTGCT	0.398	NSCLC(166;160 2029 11600 18754 19936)		NA											23	53					2.41591e-17	3.35303e-17	0.004656	1	0
ZP4	57829	broad.mit.edu	37	1	238048129	238048129	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:238048129C>A	uc001hym.2	-	10	1330	c.1330G>T	c.(1330-1332)GTG>TTG	p.V444L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	444	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAGACTGACACGCTGCAGTGC	0.507	NSCLC(166;160 2029 11600 18754 19936)		NA											14	29					1.33834e-09	1.63683e-09	0.007413	1	0
FMN2	56776	broad.mit.edu	37	1	240255781	240255781	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:240255781G>C	uc010pyd.1	+	1	597	c.372G>C	c.(370-372)TCG>TCC	p.S124S	FMN2_uc010pye.1_Silent_p.S124S	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	124					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.E124E(1)		ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCAGCCTCTCGGCGGACGAGG	0.692			NA											4	1					0	0	0.000602	0	0
OR2T12	127064	broad.mit.edu	37	1	248458101	248458102	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:248458101_248458102GG>TT	uc010pzj.1	-	1	779_780	c.779_780CC>AA	c.(778-780)CCC>CAA	p.P260Q		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGTGGGATTTGGGTCTCATATA	0.485			NA											37	64					0	0	0.004672	0	0
OR2T10	127069	broad.mit.edu	37	1	248756939	248756939	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:248756939G>T	uc010pzn.1	-	1	131	c.131C>A	c.(130-132)ACA>AAA	p.T44K		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGTATCAATGTAATATTCCA	0.413			NA											19	63					5.26018e-13	6.83959e-13	0.001882	1	0
LARP4B	23185	broad.mit.edu	37	10	860887	860887	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:860887C>A	uc001ifs.1	-	15	1860	c.1819G>T	c.(1819-1821)GAT>TAT	p.D607Y		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	607							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						AATACTCACTCGGGTAAATGA	0.517			NA											17	42					7.87624e-14	1.04293e-13	0.00278	1	0
AKR1E2	83592	broad.mit.edu	37	10	4877928	4877928	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:4877928G>T	uc001ihi.2	+	4	501	c.386G>T	c.(385-387)CGA>CTA	p.R129L	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Missense_Mutation_p.R90L|AKR1E2_uc001ihh.1_Missense_Mutation_p.R129L|AKR1E2_uc009xhw.2_Missense_Mutation_p.R129L|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.R129L	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	129						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						TCACATCCTCGAGTGCAGGAC	0.522	NSCLC(43;343 1097 20371 28813 45509)		NA											33	37					1.30998e-17	1.82565e-17	0.005524	1	0
FBXO18	84893	broad.mit.edu	37	10	5969492	5969492	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:5969492G>A	uc001iis.2	+	19	2912	c.2817G>A	c.(2815-2817)TTG>TTA	p.L939L	FBXO18_uc001iir.2_Silent_p.L882L|FBXO18_uc009xig.2_Silent_p.L865L|FBXO18_uc001iit.2_Silent_p.L990L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	939					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AAAACATTTTGACTTTGGCTG	0.448			NA											15	59					0	0	0.002299	0	0
C1QL3	389941	broad.mit.edu	37	10	16563060	16563060	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:16563060A>G	uc001ioj.1	-	1	945	c.5T>C	c.(4-6)GTG>GCG	p.V2A		NM_001010908	NP_001010908	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	2						collagen				ovary(1)	1						CAGCAGCAGCACCATCACCAC	0.682			NA											6	6					0	0	0.008291	0	0
TRDMT1	1787	broad.mit.edu	37	10	17199678	17199678	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:17199678C>G	uc001iop.2	-	8	697	c.649G>C	c.(649-651)GAT>CAT	p.D217H	TRDMT1_uc001ioq.2_Missense_Mutation_p.D193H|TRDMT1_uc001ior.2_Missense_Mutation_p.D171H|TRDMT1_uc001ios.2_Missense_Mutation_p.D146H|TRDMT1_uc009xjt.2_Missense_Mutation_p.D136H|TRDMT1_uc010qcc.1_Missense_Mutation_p.D146H|TRDMT1_uc010qcd.1_Missense_Mutation_p.D94H	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	217					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						ATGCTGCCATCAAAGCTAATA	0.343			NA											5	2					0	0	0.000602	0	0
CACNB2	783	broad.mit.edu	37	10	18803262	18803263	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:18803262_18803263CC>AT	uc001ipr.2	+	7	828_829	c.768_769CC>AT	c.(766-771)CCCCAC>CCATAC	p.H257Y	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Intron|CACNB2_uc001ipt.2_Intron|CACNB2_uc010qcl.1_Intron|CACNB2_uc001ipu.2_Missense_Mutation_p.H229Y|CACNB2_uc001ipv.2_Intron|CACNB2_uc009xka.1_Intron|CACNB2_uc001ipw.2_Intron|CACNB2_uc001ipx.2_Missense_Mutation_p.H202Y|CACNB2_uc009xkb.1_Intron|CACNB2_uc010qcm.1_Missense_Mutation_p.H203Y|CACNB2_uc001ipz.2_Intron|CACNB2_uc001ipy.2_Missense_Mutation_p.H203Y|CACNB2_uc010qcn.1_Intron|CACNB2_uc010qco.1_Intron|CACNB2_uc001iqa.2_Missense_Mutation_p.H209Y|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	257					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TAACGTCACCCCACTCCAAAGA	0.45			NA											15	41					0	0	0.004672	0	0
MYO3A	53904	broad.mit.edu	37	10	26465695	26465695	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:26465695G>T	uc001isn.2	+	31	4719	c.4359G>T	c.(4357-4359)CAG>CAT	p.Q1453H	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1453					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TTTTGTCACAGCAACTGAAGT	0.358			NA											24	27					6.38683e-12	8.1677e-12	0.008361	1	0
ASAH2	56624	broad.mit.edu	37	10	52005175	52005175	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:52005175G>T	uc001jjd.2	-	2	167	c.167C>A	c.(166-168)CCA>CAA	p.P56Q	ASAH2_uc009xos.2_Missense_Mutation_p.P56Q	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	56	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						CTGGGTGGCTGGAGGGCTTTG	0.488			NA											5	13					0.000602214	0.00064368	0.000602	1	0
IPMK	253430	broad.mit.edu	37	10	59956230	59956230	+	Silent	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:59956230T>A	uc001jkb.2	-	6	1181	c.858A>T	c.(856-858)ACA>ACT	p.T286T		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	286						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						CTAGTACTTCTGTGTCTGACA	0.378			NA											12	19					0	0	0.001368	0	0
TET1	80312	broad.mit.edu	37	10	70405772	70405772	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:70405772G>C	uc001jok.3	+	4	3791	c.3286G>C	c.(3286-3288)GAG>CAG	p.E1096Q		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1096					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TATAAAACCAGAGGACAAAAA	0.378			NA											6	49					0	0	0.001984	0	0
MYST4	23522	broad.mit.edu	37	10	76780503	76780503	+	Silent	SNP	G	G	C	rs140113295	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:76780503G>C	uc001jwn.1	+	14	3286	c.2793G>C	c.(2791-2793)ACG>ACC	p.T931T	MYST4_uc001jwm.1_Silent_p.T639T|MYST4_uc001jwo.1_Silent_p.T639T|MYST4_uc001jwp.1_Silent_p.T748T	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	931	Catalytic.|Interaction with BRPF1.			TGM -> RHV (in Ref. 2; AAL56647).	histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GCAGAGCGACGGGCATGTGCC	0.567			NA	T	CREBBP	AML								10	51					0	0	0.00245	0	0
KCNMA1	3778	broad.mit.edu	37	10	78651358	78651358	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:78651358C>T	uc001jxn.2	-	26	3444	c.3267G>A	c.(3265-3267)CCG>CCA	p.P1089P	KCNMA1_uc001jxj.2_Silent_p.P1035P|KCNMA1_uc001jxk.1_Silent_p.P707P|KCNMA1_uc009xrt.1_Silent_p.P880P|KCNMA1_uc001jxl.1_Silent_p.P714P|KCNMA1_uc001jxo.2_Silent_p.P1072P|KCNMA1_uc001jxm.2_Silent_p.P1031P|KCNMA1_uc001jxq.2_Silent_p.P1061P|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1089	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CCAGTGTCTGCGGGGTGCTGT	0.632			NA											7	33					0	0	0.00308	0	0
KCNMA1	3778	broad.mit.edu	37	10	78674762	78674762	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:78674762G>T	uc001jxn.2	-	24	3125	c.2948C>A	c.(2947-2949)CCA>CAA	p.P983Q	KCNMA1_uc001jxj.2_Missense_Mutation_p.P929Q|KCNMA1_uc001jxk.1_Missense_Mutation_p.P601Q|KCNMA1_uc009xrt.1_Missense_Mutation_p.P774Q|KCNMA1_uc001jxl.1_Missense_Mutation_p.P608Q|KCNMA1_uc001jxo.2_Missense_Mutation_p.P966Q|KCNMA1_uc001jxm.2_Missense_Mutation_p.P925Q|KCNMA1_uc001jxq.2_Missense_Mutation_p.P928Q	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	983	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CCCGTGCACTGGGCTGTTATC	0.478			NA											127	70					3.69866e-55	6.029e-55	0.00361	1	0
FAM190B	54462	broad.mit.edu	37	10	86259650	86259650	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:86259650C>G	uc001kdh.1	+	10	2539	c.2345C>G	c.(2344-2346)TCC>TGC	p.S782C	FAM190B_uc010qmd.1_Intron|FAM190B_uc001kdi.1_Intron|FAM190B_uc010qme.1_Missense_Mutation_p.S209C	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	782										ovary(3)|skin(1)	4						TCTGCTCCCTCCTTCTCTCCT	0.507			NA											11	87					0	0	0.001368	0	0
OPN4	94233	broad.mit.edu	37	10	88418396	88418396	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:88418396G>A	uc001kdq.2	+	4	807	c.580G>A	c.(580-582)GTT>ATT	p.V194I	OPN4_uc001kdp.2_Missense_Mutation_p.V205I|OPN4_uc010qmk.1_Missense_Mutation_p.V205I|OPN4_uc009xsx.1_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	194	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CCTGCTGGGCGTTTGGCTCTA	0.647			NA											4	91					0	0	0.001168	0	0
LIPF	8513	broad.mit.edu	37	10	90427398	90427398	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:90427398G>C	uc001kfg.1	+	3	344	c.178G>C	c.(178-180)GAA>CAA	p.E60Q	LIPF_uc009xtk.2_Missense_Mutation_p.E60Q|LIPF_uc001kfh.1_Missense_Mutation_p.E70Q|LIPF_uc010qmt.1_Missense_Mutation_p.E70Q|LIPF_uc010qmu.1_Missense_Mutation_p.E60Q	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	60					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TTATATTCTTGAAGTCAATAG	0.259			NA											3	80					0	0	0.001168	0	0
TNKS2	80351	broad.mit.edu	37	10	93619378	93619378	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:93619378A>G	uc001khp.2	+	25	3551	c.3254A>G	c.(3253-3255)AAA>AGA	p.K1085R		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1085	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				CCAGTTCACAAAGACAGATCT	0.388			NA											32	23					0	0	0.006999	0	0
DNTT	1791	broad.mit.edu	37	10	98064330	98064330	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:98064330T>A	uc001kmf.2	+	1	246	c.76T>A	c.(76-78)TCT>ACT	p.S26T	DNTT_uc001kmg.2_Missense_Mutation_p.S26T	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	26					DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		GATGGCCTCCTCTCCTCAAGA	0.567			NA											12	27					0	0	0.001855	0	0
ANKRD2	26287	broad.mit.edu	37	10	99338071	99338071	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:99338071C>A	uc001knw.2	+	3	554	c.345C>A	c.(343-345)CTC>CTA	p.L115L	ANKRD2_uc009xvu.2_Silent_p.L115L	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	115					muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		TCCAGAACCTCATCGAGCTGC	0.667			NA											13	19					1.5739e-10	1.96786e-10	0.004007	1	0
PAX2	5076	broad.mit.edu	37	10	102587431	102587431	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:102587431C>G	uc001krk.3	+	12	1837	c.1287C>G	c.(1285-1287)GTC>GTG	p.V429V	PAX2_uc001krl.3_3'UTR|PAX2_uc001krm.3_3'UTR|PAX2_uc001kro.3_3'UTR|PAX2_uc001krn.3_Silent_p.V406V|PAX2_uc010qps.1_3'UTR	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	Error:Variant_position_missing_in_Q02962_after_alignment					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TCCACATCGTCCCCGTCTGAC	0.711			NA											7	21					0	0	0.001984	0	0
PDCD11	22984	broad.mit.edu	37	10	105182844	105182844	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:105182844G>T	uc001kwy.1	+	18	2684	c.2597G>T	c.(2596-2598)GGG>GTG	p.G866V		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	866					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTATTCAGTGGGGGTCCAGTG	0.567			NA											24	38					3.7963e-18	5.33492e-18	0.00333	1	0
SLK	9748	broad.mit.edu	37	10	105779539	105779539	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:105779539G>C	uc001kxo.1	+	16	3214	c.3180G>C	c.(3178-3180)TTG>TTC	p.L1060F	SLK_uc001kxp.1_Missense_Mutation_p.L1029F	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1060	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTGAGGAATTGAAAAACAGAC	0.393	NSCLC(111;540 1651 1927 4474 17706)		NA											15	93					0	0	0.00499	0	0
ATRNL1	26033	broad.mit.edu	37	10	117607386	117607386	+	Splice_Site	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:117607386A>T	uc001lcg.2	+	28	4290	c.3904_splice	c.e28-2	p.G1302_splice	ATRNL1_uc010qsm.1_Splice_Site_p.G431_splice|ATRNL1_uc010qsn.1_Splice_Site	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor							integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTTCTTTTTCAGGGGGCACCC	0.433			NA											5	21					0	0	0.00308	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118236601	118236601	+	Splice_Site	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:118236601G>A	uc001lcl.3	+	12	1442	c.1341_splice	c.e12-1	p.K447_splice		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor						lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AAAACTTTCAGATCTACCTTC	0.358			NA											9	30					0	0	0.004482	0	0
ADAM12	8038	broad.mit.edu	37	10	127724787	127724787	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:127724787G>T	uc001ljk.2	-	21	2879	c.2466C>A	c.(2464-2466)CTC>CTA	p.L822L	ADAM12_uc010qul.1_Silent_p.L773L	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	822	Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GAGCCCGGTGGAGGGGAGGAA	0.582			NA											48	64					9.90819e-18	1.38468e-17	0.00361	1	0
ADAM12	8038	broad.mit.edu	37	10	127731628	127731628	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:127731628G>A	uc001ljk.2	-	18	2507	c.2094C>T	c.(2092-2094)AGC>AGT	p.S698S	ADAM12_uc010qul.1_Silent_p.S649S|ADAM12_uc001ljm.2_Silent_p.S698S|ADAM12_uc001ljn.2_Silent_p.S695S|ADAM12_uc001ljl.3_Silent_p.S695S	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	698	Extracellular (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GGATGGGGCCGCTGTCTGTGC	0.637			NA											3	38					0	0	0.009096	0	0
EBF3	253738	broad.mit.edu	37	10	131639150	131639150	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:131639150G>A	uc001lki.1	-	14	1551	c.1492C>T	c.(1492-1494)CCT>TCT	p.P498S		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	507	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AGAAATCCAGGCGAGCCAGGG	0.522			NA											10	91					0	0	0.00245	0	0
GLRX3	10539	broad.mit.edu	37	10	131973129	131973129	+	Splice_Site	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:131973129A>T	uc001lkm.1	+	9	847	c.825_splice	c.e9-2	p.G275_splice	GLRX3_uc001lkn.1_Splice_Site_p.G275_splice|GLRX3_uc001lko.2_Splice_Site	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3						cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TCTTTTTTGCAGTGTTGAATA	0.318			NA											38	26					0	0	0.002852	0	0
EPS8L2	64787	broad.mit.edu	37	11	724778	724778	+	Silent	SNP	C	C	T	rs149900433		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:724778C>T	uc001lqt.2	+	16	1756	c.1509C>T	c.(1507-1509)TTC>TTT	p.F503F	EPS8L2_uc001lqu.2_Silent_p.F503F|EPS8L2_uc010qwk.1_Silent_p.F519F|EPS8L2_uc001lqv.2_Silent_p.F458F|EPS8L2_uc001lqw.2_Silent_p.F115F|EPS8L2_uc001lqx.2_Silent_p.F115F|EPS8L2_uc001lqy.2_Silent_p.F11F	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	503	SH3.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGTATGACTTCACAGCCCGAA	0.607			NA											12	77					0	0	0.007413	0	0
NUP98	4928	broad.mit.edu	37	11	3794932	3794932	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:3794932A>C	uc001lyh.2	-	6	824	c.533T>G	c.(532-534)GTT>GGT	p.V178G	NUP98_uc001lyi.2_Missense_Mutation_p.V178G|NUP98_uc001lyj.1_Missense_Mutation_p.V178G|NUP98_uc001lyk.1_Missense_Mutation_p.V178G|NUP98_uc010qxv.1_Missense_Mutation_p.V141G	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	178	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GTTAGTGCTAACTCCAGCTTT	0.378			NA	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								42	21					0	0	0.00361	0	0
OR51T1	401665	broad.mit.edu	37	11	4904000	4904000	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:4904000C>A	uc010qyp.1	+	1	952	c.952C>A	c.(952-954)CCT>ACT	p.P318T		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTGCTGAACCCTATCATTTA	0.512			NA											44	72					2.55665e-31	3.9324e-31	0.00361	1	0
OR51B6	390058	broad.mit.edu	37	11	5372961	5372961	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:5372961C>T	uc010qzb.1	+	1	224	c.224C>T	c.(223-225)ACA>ATA	p.T75I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	75	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATTGACCACAATGCCCACA	0.463			NA											28	59					0	0	0.00632	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537381	5537381	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:5537381G>C	uc001maz.3	-	1	576	c.291C>G	c.(289-291)TAC>TAG	p.Y97*	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	97	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TGATGACCAAGTAGATGGTGT	0.537			NA											60	24					0	0	0.00361	0	0
OR52E4	390081	broad.mit.edu	37	11	5906244	5906244	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:5906244C>A	uc010qzs.1	+	1	722	c.722C>A	c.(721-723)ACC>AAC	p.T241N	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCTTCAATACCTGTGGTTCT	0.403			NA											50	76					9.52127e-25	1.41905e-24	0.00361	1	0
CNGA4	1262	broad.mit.edu	37	11	6260485	6260485	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:6260485C>A	uc001mco.2	+	1	156	c.49C>A	c.(49-51)CCA>ACA	p.P17T	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Intron	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	17	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCCCCAGCCCCATCCAAGGC	0.557			NA											15	39					9.16793e-09	1.09863e-08	0.00499	1	0
SYT9	143425	broad.mit.edu	37	11	7334683	7334683	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:7334683G>A	uc001mfe.2	+	3	792	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	185	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ATATCCAGCAGCTTCAAAAAC	0.393			NA											8	57					0	0	0.008291	0	0
LDHA	3939	broad.mit.edu	37	11	18427047	18427047	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:18427047C>G	uc001mok.3	+	7	1034	c.762C>G	c.(760-762)CTC>CTG	p.L254L	LDHA_uc010rdc.1_Silent_p.L196L|LDHA_uc009yhn.2_Silent_p.L253L|LDHA_uc009yho.2_Silent_p.L81L|LDHA_uc001mol.3_Intron|LDHA_uc010rdd.1_Silent_p.L283L	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	254					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	CTATTGGACTCTCTGTAGCAG	0.448			NA											4	91					0	0	0.009096	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637123	18637123	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:18637123G>C	uc001moy.2	-	3	914	c.698C>G	c.(697-699)TCT>TGT	p.S233C	SPTY2D1_uc010rdi.1_Missense_Mutation_p.S233C	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	233										breast(1)	1						TTCTTTCTGAGAGGGTGCCTT	0.443			NA											24	113					0	0	0.007291	0	0
KCNA4	3739	broad.mit.edu	37	11	30032313	30032313	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:30032313G>C	uc001msk.2	-	2	3065	c.1913C>G	c.(1912-1914)ACA>AGA	p.T638R		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	638						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTTTTTATCTGTCTCACTGTC	0.458			NA											32	71					0	0	0.004878	0	0
PAX6	5080	broad.mit.edu	37	11	31824340	31824340	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:31824340C>A	uc001mtd.3	-	4	943	c.53G>T	c.(52-54)GGG>GTG	p.G18V	PAX6_uc001mte.3_Missense_Mutation_p.G18V|PAX6_uc001mtg.3_Missense_Mutation_p.G18V|PAX6_uc001mtf.3_Missense_Mutation_p.G18V|PAX6_uc001mth.3_Missense_Mutation_p.G18V|PAX6_uc009yjr.2_Missense_Mutation_p.G18V	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	18	Paired.		G -> W (in AN).		blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					CAGTGGCCGCCCGTTGACAAA	0.483			NA							Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				16	21					2.89027e-11	3.64535e-11	0.002299	1	0
TRAF6	7189	broad.mit.edu	37	11	36511633	36511633	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:36511633C>A	uc001mwr.1	-	8	1664	c.1324G>T	c.(1324-1326)GTA>TTA	p.V442L	uc001mwq.1_5'Flank|TRAF6_uc001mws.1_Missense_Mutation_p.V442L	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	442	MATH.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				TTTTGCCTTACAGGTGCTTCA	0.483			NA											21	24					3.8784e-16	5.30259e-16	0.001882	1	0
RAG1	5896	broad.mit.edu	37	11	36597395	36597395	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:36597395A>G	uc001mwu.3	+	2	2665	c.2541A>G	c.(2539-2541)AAA>AAG	p.K847K	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	847					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TGAACCTCAAACCAATCATGA	0.478	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				8	44					0	0	0.006214	0	0
EXT2	2132	broad.mit.edu	37	11	44265763	44265763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:44265763C>T	uc001mxz.2	+	14	2417	c.2083C>T	c.(2083-2085)CGA>TGA	p.R695*	EXT2_uc010rfo.1_Nonsense_Mutation_p.R723*|EXT2_uc001mxy.2_Nonsense_Mutation_p.R708*|EXT2_uc009ykt.2_Nonsense_Mutation_p.R705*|EXT2_uc001mya.2_Nonsense_Mutation_p.R728*	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	695	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GGTGGAACACCGAGCTGACCC	0.517			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				5	99					0	0	0.001168	0	0
SYT13	57586	broad.mit.edu	37	11	45274040	45274040	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:45274040G>C	uc001myq.2	-	4	904	c.778C>G	c.(778-780)CTG>GTG	p.L260V	SYT13_uc009yku.1_Missense_Mutation_p.L116V	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	260	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						TCCAGGCCCAGGCGGAGCTCC	0.657			NA									OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	60					0	0	0.008871	0	0
OR5L2	26338	broad.mit.edu	37	11	55595525	55595525	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:55595525C>G	uc001nhy.1	+	1	831	c.831C>G	c.(829-831)TTC>TTG	p.F277L		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CCACCGTGTTCTACACAGTTG	0.468			NA								HNSCC(27;0.073)			7	49					0	0	0.001984	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735431	55735431	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:55735431C>A	uc010rit.1	-	1	509	c.509G>T	c.(508-510)TGT>TTT	p.C170F		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					CGGGATGTCACAAAAGAAATG	0.408			NA											10	39					6.42651e-13	8.33464e-13	0.000978	1	0
OR5F1	338674	broad.mit.edu	37	11	55761839	55761839	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:55761839T>C	uc010riv.1	-	1	263	c.263A>G	c.(262-264)GAG>GGG	p.E88G		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GGTTTTCTTCTCTGATAATAA	0.448			NA											16	57					0	0	0.006122	0	0
OR8I2	120586	broad.mit.edu	37	11	55860955	55860955	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:55860955C>A	uc010rix.1	+	1	172	c.172C>A	c.(172-174)CCT>ACT	p.P58T		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GCTTCACACCCCTATGTACTT	0.378			NA											68	112					3.27973e-32	5.06775e-32	0.00361	1	0
OR8I2	120586	broad.mit.edu	37	11	55861147	55861147	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:55861147C>A	uc010rix.1	+	1	364	c.364C>A	c.(364-366)CGC>AGC	p.R122S		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GGCCTACAATCGCTACATAGC	0.433			NA											63	34					3.94896e-32	6.09251e-32	0.00361	1	0
OR5T2	219464	broad.mit.edu	37	11	56000397	56000397	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:56000397T>A	uc010rjc.1	-	1	265	c.265A>T	c.(265-267)ATT>TTT	p.I89F		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	89	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I89I(1)		ovary(2)	2	Esophageal squamous(21;0.00448)					GAATCCCTAATGACCACTAAA	0.403			NA											6	33					0	0	0.000978	0	0
CD6	923	broad.mit.edu	37	11	60777208	60777209	+	Missense_Mutation	DNP	AA	AA	TG			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:60777208_60777209AA>TG	uc001nqq.2	+	5	1169_1170	c.946_947AA>TG	c.(946-948)AAG>TGG	p.K316W	CD6_uc009yni.2_Intron|CD6_uc009ynj.2_Intron|CD6_uc001nqp.2_Missense_Mutation_p.K316W|CD6_uc001nqr.2_Missense_Mutation_p.K316W|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.K316W	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	316	SRCR 3.|Extracellular (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TGAGAGGCCCAAGGGGCTGCCC	0.604	Pancreas(169;904 2017 4767 38890 42505)		NA											14	56					0	0	0.004672	0	0
INCENP	3619	broad.mit.edu	37	11	61917542	61917542	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:61917542C>G	uc001nsw.1	+	18	2607	c.2405C>G	c.(2404-2406)ACC>AGC	p.T802S	INCENP_uc001nsx.1_Missense_Mutation_p.T798S|INCENP_uc001nsy.1_Missense_Mutation_p.T216S	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	802					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						CCAGCTTGTACCTCATATCAG	0.557			NA											12	75					0	0	0.004007	0	0
BSCL2	26580	broad.mit.edu	37	11	62472928	62472928	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:62472928G>A	uc001nuo.1	-	2	481	c.57C>T	c.(55-57)GTC>GTT	p.V19V	BSCL2_uc009yoc.1_Silent_p.V19V|BSCL2_uc001nup.2_Silent_p.V19V|BSCL2_uc001nuq.1_Silent_p.V19V|BSCL2_uc001nur.3_Silent_p.V83V|BSCL2_uc009yod.2_Silent_p.V83V|BSCL2_uc001nut.3_Silent_p.V83V|HNRNPUL2_uc001nuu.1_RNA|GNG3_uc001nuv.2_5'Flank	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	19	Cytoplasmic (Potential).				cell death	integral to endoplasmic reticulum membrane					0						GGCCTGCCAAGACTTGGCCCA	0.622			NA											11	38					0	0	0.001368	0	0
STX5	6811	broad.mit.edu	37	11	62598658	62598658	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:62598658G>C	uc001nvh.2	-	2	212	c.58C>G	c.(58-60)CTC>GTC	p.L20V	STX5_uc010rmi.1_Intron|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Intron|STX5_uc010rmj.1_Missense_Mutation_p.L20V|STX5_uc001nvj.2_5'UTR	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	20	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						GTCTTTGAGAGACCCAGGTAG	0.607			NA											2	8					0	0	0.004672	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74915622	74915622	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:74915622G>A	uc001owb.2	+	14	2514	c.2127G>A	c.(2125-2127)GTG>GTA	p.V709V	SLCO2B1_uc010rrr.1_Silent_p.V565V|SLCO2B1_uc010rrs.1_Silent_p.V593V|SLCO2B1_uc001owc.2_Silent_p.V482V|SLCO2B1_uc001owd.2_Silent_p.V687V	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	709	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	ATTCCCGAGTGTGAGCTGTCT	0.502			NA											9	33					0	0	0.008291	0	0
FAT3	120114	broad.mit.edu	37	11	92543184	92543184	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:92543184T>C	uc001pdj.3	+	12	9440	c.9423T>C	c.(9421-9423)TAT>TAC	p.Y3141Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3141	Cadherin 29.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTGTGTCTATGAGAACACAG	0.527			NA								TCGA Ovarian(4;0.039)			25	40					0	0	0.00632	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714731	92714732	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:92714731_92714732GG>TT	uc001pdk.1	+	2	445_446	c.342_343GG>TT	c.(340-345)AAGGCC>AATTCC	p.114_115KA>NS		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	114_115	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AGCACTGCAAGGCCAGCGCCTT	0.589			NA											14	84					0	0	0.004672	0	0
MMP20	9313	broad.mit.edu	37	11	102487653	102487653	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:102487653G>T	uc001phc.2	-	2	277	c.264C>A	c.(262-264)GAC>GAA	p.D88E		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	88					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		TTGTGGTCTGGTCTAACTTCC	0.463			NA											18	22					2.89027e-11	3.64535e-11	0.002299	1	0
GRIA4	2893	broad.mit.edu	37	11	105781191	105781191	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:105781191G>T	uc001pix.2	+	10	1635	c.1189G>T	c.(1189-1191)GTC>TTC	p.V397F	GRIA4_uc001piu.1_Missense_Mutation_p.V397F|GRIA4_uc001piw.2_Missense_Mutation_p.V397F|GRIA4_uc009yxk.1_Missense_Mutation_p.V397F	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	397	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GGATAAGTTAGTCTTGATTCA	0.358			NA											10	63					1.08611e-07	1.26254e-07	0.000978	1	0
DDX10	1662	broad.mit.edu	37	11	108562632	108562632	+	Silent	SNP	G	G	A	rs144415130		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:108562632G>A	uc001pkm.2	+	8	1070	c.1005G>A	c.(1003-1005)CGG>CGA	p.R335R	DDX10_uc001pkl.1_Silent_p.R335R	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	335	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGTTTTGCCGGCTACGTCCTG	0.418			NA	T	NUP98	AML*								48	32					0	0	0.00361	0	0
PIH1D2	120379	broad.mit.edu	37	11	111943723	111943723	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:111943723A>T	uc001pmq.3	-	2	258	c.176T>A	c.(175-177)CTG>CAG	p.L59Q	PIH1D2_uc009yyl.2_Missense_Mutation_p.L59Q|PIH1D2_uc001pmp.3_Missense_Mutation_p.L59Q|PIH1D2_uc010rws.1_Missense_Mutation_p.L59Q|C11orf57_uc001pmu.2_5'Flank|C11orf57_uc001pmw.3_5'Flank|C11orf57_uc001pmt.3_5'Flank|C11orf57_uc001pmr.3_5'Flank|C11orf57_uc001pmv.3_5'Flank|C11orf57_uc001pms.3_5'Flank	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2 isoform 1	59										ovary(1)	1		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		TCGACATACCAGAATCCTGGT	0.448			NA											29	25					0	0	0.004878	0	0
DRD2	1813	broad.mit.edu	37	11	113281511	113281511	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:113281511T>C	uc001pnz.2	-	7	1591	c.1270A>G	c.(1270-1272)ATC>GTC	p.I424V	DRD2_uc010rwv.1_Missense_Mutation_p.I423V|DRD2_uc001poa.3_Missense_Mutation_p.I424V|DRD2_uc001pob.3_Missense_Mutation_p.I395V	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	424	Helical; Name=7; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GTGTAGATGATGGGGTTCACG	0.567			NA											30	100					0	0	0.002445	0	0
DRD2	1813	broad.mit.edu	37	11	113283453	113283453	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:113283453G>T	uc001pnz.2	-	6	1284	c.963C>A	c.(961-963)AGC>AGA	p.S321R	DRD2_uc010rwv.1_Missense_Mutation_p.S320R|DRD2_uc001poa.3_Missense_Mutation_p.S321R|DRD2_uc001pob.3_Missense_Mutation_p.S292R	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	321	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GTTTGGCGGGGCTGTCGGGAG	0.622			NA											17	46					1.56442e-22	2.30102e-22	0.002445	1	0
DRD2	1813	broad.mit.edu	37	11	113283469	113283469	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:113283469T>G	uc001pnz.2	-	6	1268	c.947A>C	c.(946-948)CAC>CCC	p.H316P	DRD2_uc010rwv.1_Missense_Mutation_p.H315P|DRD2_uc001poa.3_Missense_Mutation_p.H316P|DRD2_uc001pob.3_Missense_Mutation_p.H287P	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	316	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGAGTGCTGTGGAGACCATG	0.617			NA											20	55					0	0	0.003271	0	0
UBE4A	9354	broad.mit.edu	37	11	118239392	118239392	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:118239392G>C	uc001psw.2	+	3	297	c.168G>C	c.(166-168)GAG>GAC	p.E56D	UBE4A_uc001psv.2_Missense_Mutation_p.E56D	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	56					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GCGTGTCAGAGAGCCTGGATG	0.443			NA											6	295					0	0	0.001984	0	0
DPAGT1	1798	broad.mit.edu	37	11	118971834	118971834	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:118971834C>T	uc001pvi.2	-	2	596	c.176G>A	c.(175-177)GGA>GAA	p.G59E	DPAGT1_uc001pvj.2_Intron|DPAGT1_uc009zaq.2_RNA|DPAGT1_uc001pvk.2_5'UTR|DPAGT1_uc010ryz.1_Missense_Mutation_p.G59E|DPAGT1_uc001pvm.1_5'Flank|DPAGT1_uc010rza.1_Intron	NM_001382	NP_001373	Q9H3H5	GPT_HUMAN	UDP-N-acetylglucosamine-dolichyl-phosphate	59	Helical; (Potential).				dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|ovary(1)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GCTGATCACTCCCTGGGATTC	0.557			NA									OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	36					0	0	0.00308	0	0
CBL	867	broad.mit.edu	37	11	119103165	119103165	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:119103165G>T	uc001pwe.2	+	2	341	c.203G>T	c.(202-204)CGG>CTG	p.R68L		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	68	Cbl-PTB.|4H.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CAGGTGGTGCGGTTGTGTCAG	0.408			NA							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				5	41					2.0095e-06	2.27053e-06	0.001984	1	0
CRTAM	56253	broad.mit.edu	37	11	122738263	122738263	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:122738263G>C	uc001pyj.2	+	8	964	c.964G>C	c.(964-966)GAA>CAA	p.E322Q	CRTAM_uc001pyk.2_Missense_Mutation_p.E123Q	NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	322	Cytoplasmic (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		ATGGAAGAAAGGTCAGTGGGC	0.458			NA											6	38					0	0	0.001168	0	0
ASAM	79827	broad.mit.edu	37	11	123065631	123065631	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:123065631G>T	uc001pyt.2	-	1	377	c.18C>A	c.(16-18)CTC>CTA	p.L6L		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	6						integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		CTAGCAAGAGGAGAAGGAGGA	0.711			NA											4	28					0.00116845	0.00123451	0.001168	1	0
OR6T1	219874	broad.mit.edu	37	11	123813849	123813849	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:123813849C>A	uc010sab.1	-	1	697	c.697G>T	c.(697-699)GAG>TAG	p.E233*		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TTCCTTCGCTCAGCAGCTGTA	0.507			NA											30	15					7.11191e-15	9.52977e-15	0.002836	1	0
OR10G7	390265	broad.mit.edu	37	11	123909520	123909520	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:123909520G>T	uc001pzq.1	-	1	189	c.189C>A	c.(187-189)AAC>AAA	p.N63K		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGAAGGACAGGTTGGTGAGGA	0.552			NA											4	74					2.32078e-09	2.82811e-09	0.003163	1	0
OR8G2	26492	broad.mit.edu	37	11	124096007	124096007	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:124096007A>T	uc010saf.1	+	1	610	c.610A>T	c.(610-612)AGC>TGC	p.S204C		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	204						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CTCCTGCTCCAGCACCTACAT	0.423			NA											24	66					0	0	0.004656	0	0
ROBO3	64221	broad.mit.edu	37	11	124743218	124743218	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:124743218G>T	uc001qbc.2	+	10	1741	c.1549G>T	c.(1549-1551)GGC>TGC	p.G517C		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	517	Ig-like C2-type 5.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GATGGACATGGGCTTCTACAG	0.542			NA											4	11					0.00116845	0.00123451	0.001168	1	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:124857495A>C	uc001qbm.3	+	8	1632	c.1373A>C	c.(1372-1374)CAC>CCC	p.H458P		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418			NA											3	62					0	0	0.004672	0	0
ETS1	2113	broad.mit.edu	37	11	128426243	128426243	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:128426243A>G	uc001qej.2	-	3	242	c.157T>C	c.(157-159)TTT>CTT	p.F53L		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TCATCCCAAAAGGGGTAGCAA	0.448			NA											3	64					0	0	0.009096	0	0
NFRKB	4798	broad.mit.edu	37	11	129762741	129762741	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:129762741C>T	uc001qfi.2	-	3	205	c.4G>A	c.(4-6)GAT>AAT	p.D2N	NFRKB_uc001qfg.2_Missense_Mutation_p.D15N|NFRKB_uc001qfh.2_Missense_Mutation_p.D25N|NFRKB_uc010sbw.1_Missense_Mutation_p.D2N	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	2					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TCTAAGGAATCCATTGTTTCT	0.507			NA											12	96					0	0	0.00245	0	0
HSN2	378465	broad.mit.edu	37	12	977998	977998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:977998G>T	uc001qiq.2	+	1	1129	c.1003G>T	c.(1003-1005)GAG>TAG	p.E335*	WNK1_uc001qio.3_Intron|WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_213655	NP_998820			hereditary sensory neuropathy, type II												0	all_cancers(10;0.0107)|all_epithelial(11;0.0151)|Ovarian(42;0.0512)|all_lung(10;0.0521)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.000967)|BRCA - Breast invasive adenocarcinoma(9;0.0178)			TTCTGTGGTAGAGCCTATCGG	0.473			NA											58	17					3.86002e-21	5.57988e-21	0.00361	1	0
ERC1	23085	broad.mit.edu	37	12	1481101	1481101	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:1481101G>A	uc001qjb.2	+	16	3124	c.2883G>A	c.(2881-2883)CTG>CTA	p.L961L	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Silent_p.L933L|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Silent_p.L961L|ERC1_uc010sdv.1_Silent_p.L669L|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	961	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TGGCTGCCCTGAAGCGGGAGA	0.502			NA											12	39					0	0	0.001855	0	0
KCNA6	3742	broad.mit.edu	37	12	4920437	4920437	+	Silent	SNP	G	G	A	rs148141793		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:4920437G>A	uc001qng.2	+	1	2096	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	410						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CCAGCATCCCGGATGCCTTCT	0.567			NA								HNSCC(72;0.22)			49	82					0	0	0.00361	0	0
A2M	2	broad.mit.edu	37	12	9224999	9224999	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:9224999A>C	uc001qvk.1	-	31	4172	c.4059T>G	c.(4057-4059)GAT>GAG	p.D1353E	A2M_uc001qvj.1_Missense_Mutation_p.D395E|A2M_uc009zgk.1_Missense_Mutation_p.D1203E	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1353					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CTTTGGGTTCATCACAAGTTT	0.428			NA											4	35					0	0	0.001168	0	0
ATF7IP	55729	broad.mit.edu	37	12	14649278	14649278	+	Splice_Site	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:14649278G>A	uc001rbw.2	+	14	3551	c.3393_splice	c.e14+1	p.T1131_splice	ATF7IP_uc001rbx.2_Splice_Site_p.T1130_splice|ATF7IP_uc001rby.3_Splice_Site_p.T1131_splice|ATF7IP_uc001rca.2_Splice_Site_p.T1131_splice	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting						DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AGTGCATACTGTAAGTGTTGA	0.388			NA											34	17					0	0	0.00874	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028237	21028237	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:21028237G>T	uc001rek.2	+	8	922	c.796G>T	c.(796-798)GGA>TGA	p.G266*	SLCO1B3_uc001rel.2_Nonsense_Mutation_p.G266*|SLCO1B3_uc010sil.1_Nonsense_Mutation_p.G266*|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Nonsense_Mutation_p.G91*	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	266	Helical; Name=6; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCTTGTGTCTGGACTATTTTC	0.373			NA											100	24					2.12867e-53	3.4531e-53	0.00361	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:25398284C>G	uc001rgp.1	-	2	216	c.35G>C	c.(34-36)GGT>GCT	p.G12A	KRAS_uc001rgq.1_Missense_Mutation_p.G12A|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			25	6					0	0	0.008361	0	0
ITPR2	3709	broad.mit.edu	37	12	26868721	26868721	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:26868721C>G	uc001rhg.2	-	7	1089	c.672G>C	c.(670-672)ATG>ATC	p.M224I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	224	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AACTATATTTCATGAATAAAG	0.358			NA											5	114					0	0	0.000602	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966616	41966616	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:41966616G>C	uc010skn.1	+	10	1506	c.1438G>C	c.(1438-1440)GAG>CAG	p.E480Q	PDZRN4_uc001rmq.3_Missense_Mutation_p.E421Q|PDZRN4_uc009zjz.2_Missense_Mutation_p.E419Q|PDZRN4_uc001rmr.2_Missense_Mutation_p.E306Q	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	679	Potential.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CATTGAGCTTGAGTGTCAGAA	0.448			NA											16	82					0	0	0.00499	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967171	41967171	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:41967171G>A	uc010skn.1	+	10	2061	c.1993G>A	c.(1993-1995)GAG>AAG	p.E665K	PDZRN4_uc001rmq.3_Missense_Mutation_p.E606K|PDZRN4_uc009zjz.2_Missense_Mutation_p.E604K|PDZRN4_uc001rmr.2_Missense_Mutation_p.E491K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	864							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				ATCTGCAGTCGAGTATGCTCA	0.478			NA											5	132					0	0	0.001168	0	0
ANO6	196527	broad.mit.edu	37	12	45803234	45803234	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:45803234G>T	uc001roo.2	+	16	2310	c.1975G>T	c.(1975-1977)GGC>TGC	p.G659C	ANO6_uc010sld.1_Missense_Mutation_p.G659C|ANO6_uc010sle.1_Missense_Mutation_p.G659C|ANO6_uc010slf.1_Missense_Mutation_p.G680C|ANO6_uc010slg.1_Missense_Mutation_p.G641C	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	659	Extracellular (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						GCAGCCTATGGGCAAACTGGG	0.383			NA											101	36					2.42198e-52	3.9226e-52	0.00361	1	0
RAPGEF3	10411	broad.mit.edu	37	12	48141561	48141561	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:48141561G>A	uc009zkp.2	-	13	1721	c.1281C>T	c.(1279-1281)GTC>GTT	p.V427V	RAPGEF3_uc001rpx.2_5'Flank|RAPGEF3_uc010sln.1_5'UTR|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.V427V|RAPGEF3_uc001rpz.3_Silent_p.V469V|RAPGEF3_uc001rqa.2_5'UTR	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	427					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CCCACTGGCTGACCAGCCGCA	0.647			NA											6	34					0	0	0.001984	0	0
MLL2	8085	broad.mit.edu	37	12	49439942	49439942	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:49439942G>T	uc001rta.3	-	17	4599	c.4599C>A	c.(4597-4599)GGC>GGA	p.G1533G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1533	RING-type 3; atypical.|PHD-type 5.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCTCTCACAGCCTGCATGCA	0.557			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	13					0.00909568	0.00941286	0.009096	1	0
LIMA1	51474	broad.mit.edu	37	12	50586328	50586328	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:50586328C>G	uc001rwj.3	-	9	1221	c.1047G>C	c.(1045-1047)AAG>AAC	p.K349N	LIMA1_uc001rwg.3_Missense_Mutation_p.K47N|LIMA1_uc001rwh.3_Missense_Mutation_p.K189N|LIMA1_uc001rwi.3_Missense_Mutation_p.K190N|LIMA1_uc001rwk.3_Missense_Mutation_p.K350N|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	349					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GAACCTCACTCTTAACCTGGG	0.448			NA											3	66					0	0	0.000602	0	0
PCBP2	5094	broad.mit.edu	37	12	53849708	53849708	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:53849708G>C	uc001sdl.3	+	5	516	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	PCBP2_uc001sdc.3_Missense_Mutation_p.E56Q|PCBP2_uc001sdb.3_Missense_Mutation_p.E56Q|PCBP2_uc001sde.3_Missense_Mutation_p.E56Q|PCBP2_uc001sdi.3_Missense_Mutation_p.E56Q|PCBP2_uc001sdd.3_Missense_Mutation_p.E56Q|PCBP2_uc001sdf.3_Missense_Mutation_p.E56Q|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Missense_Mutation_p.E56Q|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	56	KH 1.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						GAATTGTCCTGAGAGAATTAT	0.413			NA											19	249					0	0	0.001882	0	0
OR6C2	341416	broad.mit.edu	37	12	55846495	55846495	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:55846495C>G	uc001sgz.1	+	1	498	c.498C>G	c.(496-498)TTC>TTG	p.F166L		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AGCTCGAATTCTGTGACTCCA	0.438			NA											21	234					0	0	0.00333	0	0
DNAJC14	85406	broad.mit.edu	37	12	56222305	56222305	+	Silent	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:56222305A>C	uc001shx.1	-	2	342	c.138T>G	c.(136-138)GCT>GCG	p.A46A	DNAJC14_uc001shu.1_Silent_p.A46A|DNAJC14_uc009zob.1_Silent_p.A46A|DNAJC14_uc001shy.1_Silent_p.A46A	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	46					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TACCATTAGGAGCAGTCCCTG	0.602			NA											85	98					0	0	0.00361	0	0
PAN2	9924	broad.mit.edu	37	12	56712162	56712162	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:56712162G>A	uc001skx.2	-	25	3806	c.3433C>T	c.(3433-3435)CAG>TAG	p.Q1145*	CNPY2_uc001sku.1_5'Flank|CNPY2_uc001skv.2_5'Flank|PAN2_uc001skw.2_Nonsense_Mutation_p.Q293*|PAN2_uc001skz.2_Nonsense_Mutation_p.Q1144*|PAN2_uc001sky.2_Nonsense_Mutation_p.Q1141*	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1145	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CGGTACAGCTGAAGGGCTGTG	0.493			NA											20	152					0	0	0.003954	0	0
LRP1	4035	broad.mit.edu	37	12	57605102	57605102	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:57605102G>A	uc001snd.2	+	84	13526	c.13060G>A	c.(13060-13062)GTC>ATC	p.V4354I		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4354	EGF-like 21.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCTGTGTGGTCAACAAGCA	0.527			NA											45	91					0	0	0.00361	0	0
SRGAP1	57522	broad.mit.edu	37	12	64437254	64437254	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:64437254C>A	uc010ssp.1	+	6	756	c.700C>A	c.(700-702)CTA>ATA	p.L234I	SRGAP1_uc001srt.2_Missense_Mutation_p.L234I|SRGAP1_uc001srv.2_Missense_Mutation_p.L194I	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	234					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AGAAAATAAGCTAAAATCAAT	0.343			NA											33	16					8.69298e-16	1.1821e-15	0.006999	1	0
XPOT	11260	broad.mit.edu	37	12	64812733	64812733	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:64812733G>A	uc001ssb.2	+	6	774	c.348G>A	c.(346-348)GAG>GAA	p.E116E	XPOT_uc009zqm.1_Silent_p.E26E	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	116	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TTGTTACAGAGTATCTCACTA	0.438			NA											3	87					0	0	0.009096	0	0
TRHDE	29953	broad.mit.edu	37	12	72667195	72667195	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:72667195C>A	uc001sxa.2	+	1	667	c.637C>A	c.(637-639)CAA>AAA	p.Q213K	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	213	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCTCTACCCGCAAACCCAGGT	0.567			NA											12	114					6.31663e-08	7.38526e-08	0.003163	1	0
OSBPL8	114882	broad.mit.edu	37	12	76786453	76786453	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:76786453C>T	uc001sye.1	-	10	1317	c.837G>A	c.(835-837)AAG>AAA	p.K279K	OSBPL8_uc001syf.1_Silent_p.K237K|OSBPL8_uc001syg.1_Silent_p.K237K|OSBPL8_uc001syh.1_Silent_p.K254K	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	279					lipid transport		lipid binding			ovary(1)	1						GGTCATGTTCCTTTCCTTCTC	0.408			NA											10	69					0	0	0.000978	0	0
TMTC3	160418	broad.mit.edu	37	12	88584229	88584229	+	Splice_Site	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:88584229G>C	uc001tau.2	+	12	1757	c.1537_splice	c.e12-1	p.I513_splice		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat							integral to membrane	binding			skin(1)	1						CTTCTAAACAGATTATTCCTG	0.348			NA											12	59					0	0	0.001855	0	0
AMDHD1	144193	broad.mit.edu	37	12	96354210	96354210	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:96354210A>G	uc001tel.1	+	5	728	c.622A>G	c.(622-624)ATC>GTC	p.I208V	AMDHD1_uc009zth.1_Missense_Mutation_p.I99V	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	208					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						TGATGACATCATCAATAACCA	0.403			NA											8	43					0	0	0.008291	0	0
C12orf63	374467	broad.mit.edu	37	12	97158910	97158910	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:97158910T>G	uc001tet.1	+	27	3548	c.3470T>G	c.(3469-3471)ATG>AGG	p.M1157R		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1157										skin(6)|ovary(1)	7						AATACTAGAATGCATAAAGTT	0.323			NA											66	68					0	0	0.00361	0	0
ANKS1B	56899	broad.mit.edu	37	12	100166819	100166819	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:100166819G>C	uc001tge.1	-	8	1426	c.1009C>G	c.(1009-1011)CTC>GTC	p.L337V	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Missense_Mutation_p.L303V	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	337						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TCTTGACAGAGTTTTATTTCA	0.333			NA											25	19					0	0	0.008361	0	0
SLC17A8	246213	broad.mit.edu	37	12	100811895	100811895	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:100811895G>T	uc010svi.1	+	11	1699	c.1386G>T	c.(1384-1386)ATG>ATT	p.M462I	SLC17A8_uc009ztx.2_Missense_Mutation_p.M412I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	462	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TCTCTGGAATGGTCTGTCCCC	0.502			NA											48	57					3.21867e-24	4.77594e-24	0.00361	1	0
STAB2	55576	broad.mit.edu	37	12	104025458	104025458	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:104025458C>T	uc001tjw.2	+	6	756	c.570C>T	c.(568-570)CCC>CCT	p.P190P		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	190	Extracellular (Potential).|EGF-like 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACACTGGCCCCAAGTGTGACA	0.483			NA											20	129					0	0	0.001882	0	0
STAB2	55576	broad.mit.edu	37	12	104049082	104049082	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:104049082A>G	uc001tjw.2	+	14	1791	c.1605A>G	c.(1603-1605)TTA>TTG	p.L535L		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	535	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GATCTTTGTTAGAGGTAAGCA	0.294			NA											53	53					0	0	0.00361	0	0
STAB2	55576	broad.mit.edu	37	12	104152923	104152923	+	Silent	SNP	C	C	A	rs112523896		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:104152923C>A	uc001tjw.2	+	65	7306	c.7120C>A	c.(7120-7122)CGG>AGG	p.R2374R	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2374	Extracellular (Potential).|FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CTTGTCTGGGCGGGACATCGA	0.463			NA											98	60					5.41809e-49	8.73299e-49	0.00361	1	0
MMAB	326625	broad.mit.edu	37	12	109994891	109994891	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:109994891C>A	uc001tou.2	-	9	768	c.695G>T	c.(694-696)GGG>GTG	p.G232V	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Missense_Mutation_p.G141V|MMAB_uc001tox.2_Missense_Mutation_p.G180V	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	232					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCTTGATTCCCCTCCTTCAT	0.478			NA											43	25					6.14515e-18	8.62372e-18	0.00361	1	0
CUX2	23316	broad.mit.edu	37	12	111749936	111749936	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:111749936A>G	uc001tsa.1	+	16	2086	c.1933A>G	c.(1933-1935)ACA>GCA	p.T645A		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	645						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CACGCCTGAGACAGGCTCAGA	0.612			NA											6	23					0	0	0.006214	0	0
ATXN2	6311	broad.mit.edu	37	12	111956120	111956120	+	Silent	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:111956120T>G	uc001tsj.2	-	9	1740	c.1578A>C	c.(1576-1578)TCA>TCC	p.S526S	ATXN2_uc001tsh.2_Silent_p.S261S|ATXN2_uc001tsi.2_Silent_p.S237S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Silent_p.S261S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	526					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						AAGTGGATCTTGATGGCATGG	0.453			NA											31	137					0	0	0.004878	0	0
ACAD10	80724	broad.mit.edu	37	12	112130648	112130648	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:112130648G>C	uc001tsq.2	+	2	335	c.135G>C	c.(133-135)GTG>GTC	p.V45V	ACAD10_uc009zvw.2_Silent_p.V45V|ACAD10_uc001tso.3_Silent_p.V45V|ACAD10_uc001tsp.2_Silent_p.V45V|ACAD10_uc009zvx.2_Silent_p.V45V	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	45							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						ACAGAGCGGTGATTTTCGACA	0.567			NA											24	114					0	0	0.008361	0	0
C12orf51	283450	broad.mit.edu	37	12	112717042	112717042	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:112717042T>C	uc009zwc.2	-	3	513	c.495A>G	c.(493-495)TCA>TCG	p.S165S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TTTTTAAAGATGACAAACCAC	0.398			NA											45	18					0	0	0.00361	0	0
ATP8A2	51761	broad.mit.edu	37	13	26402301	26402301	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:26402301G>C	uc001uqk.2	+	28	2867	c.2725G>C	c.(2725-2727)GAA>CAA	p.E909Q	ATP8A2_uc010tdi.1_Intron|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.E459Q	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	869	Extracellular (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GATTTTATTTGAACGTTGGTG	0.373			NA											23	55					0	0	0.007291	0	0
NBEA	26960	broad.mit.edu	37	13	36046592	36046592	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:36046592G>T	uc001uvb.2	+	41	6710	c.6504G>T	c.(6502-6504)AAG>AAT	p.K2168N	NBEA_uc010abi.2_Missense_Mutation_p.K824N|NBEA_uc010tee.1_Translation_Start_Site	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2168						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGGTGGCCAAGGGGACTCTCT	0.567			NA											22	27					1.64293e-13	2.16413e-13	0.00333	1	0
TRPC4	7223	broad.mit.edu	37	13	38320089	38320089	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:38320089C>A	uc001uws.2	-	3	1117	c.882G>T	c.(880-882)AAG>AAT	p.K294N	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.K294N|TRPC4_uc010tey.1_Missense_Mutation_p.K294N|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.K294N|TRPC4_uc010aby.2_Missense_Mutation_p.K294N	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	294	Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTTGACGGTACTTAATGGCCA	0.373			NA											47	178					1.82294e-38	2.89205e-38	0.00361	1	0
ARL11	115761	broad.mit.edu	37	13	50204835	50204835	+	Silent	SNP	C	C	A	rs145617860		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:50204835C>A	uc001vdf.1	+	2	398	c.252C>A	c.(250-252)CTC>CTA	p.L84L		NM_138450	NP_612459	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	84					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		CAGATATCCTCGTGTACGTGC	0.607			NA											30	54					1.61788e-16	2.22403e-16	0.002445	1	0
CKAP2	26586	broad.mit.edu	37	13	53029722	53029722	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:53029722C>A	uc001vgv.2	+	1	228	c.31C>A	c.(31-33)CAG>AAG	p.Q11K	CKAP2_uc001vgt.2_Missense_Mutation_p.Q11K|CKAP2_uc001vgu.2_Missense_Mutation_p.Q11K|CKAP2_uc010tha.1_5'Flank	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	11					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		CCAGGACCTGCAGCTGCCCCC	0.468			NA											9	41					2.80697e-09	3.38784e-09	0.000978	1	0
LOC647288	647288	broad.mit.edu	37	13	75814397	75814398	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:75814397_75814398GG>TT	uc010ths.1	-	1	120_121	c.79_80CC>AA	c.(79-81)CCT>AAT	p.P27N		NR_027466				Homo sapiens mRNA; cDNA DKFZp434F0327 (from clone DKFZp434F0327).												0						CATACTCTCAGGTAGTGCTGCC	0.545			NA											6	29					0	0	0.004672	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369289	86369289	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:86369289G>T	uc001vll.1	-	2	1814	c.1355C>A	c.(1354-1356)CCA>CAA	p.P452Q	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	452	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AAAGGTTCCTGGCAGTATTTC	0.358			NA											5	38					0.000602214	0.00064368	0.000602	1	0
SLITRK5	26050	broad.mit.edu	37	13	88328530	88328530	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:88328530C>T	uc001vln.2	+	2	1106	c.887C>T	c.(886-888)CCG>CTG	p.P296L	SLITRK5_uc010tic.1_Missense_Mutation_p.P55L	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	296	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GAGATGAGGCCGCAGACGCCT	0.532			NA											30	41					0	0	0.00623	0	0
ITGBL1	9358	broad.mit.edu	37	13	102250501	102250501	+	Splice_Site	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr13:102250501A>T	uc001vpb.2	+	7	1088	c.869_splice	c.e7-2	p.G290_splice	ITGBL1_uc010agb.2_Splice_Site_p.G241_splice|ITGBL1_uc001vpc.3_Splice_Site_p.G149_splice	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat						cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTCACTGTGAAGGTCATGGAC	0.423			NA											36	74					0	0	0.00361	0	0
OR4L1	122742	broad.mit.edu	37	14	20528637	20528637	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:20528637C>T	uc001vwn.1	+	1	434	c.434C>T	c.(433-435)GCG>GTG	p.A145V		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAGGGGTTTGCGATACTTTCA	0.388			NA											30	47					0	0	0.002836	0	0
RNASE10	338879	broad.mit.edu	37	14	20979113	20979113	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:20979113C>G	uc010tlj.1	+	1	483	c.483C>G	c.(481-483)CTC>CTG	p.L161L	RNASE10_uc001vxp.2_Silent_p.L189L	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	161						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CCTGTGAGCTCAAGGGGGGAA	0.478			NA											12	40					0	0	0.003163	0	0
SALL2	6297	broad.mit.edu	37	14	21991583	21991583	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:21991583T>C	uc001wbe.2	-	2	2561	c.2279A>G	c.(2278-2280)GAG>GGG	p.E760G	SALL2_uc010tly.1_Missense_Mutation_p.E758G|SALL2_uc010tlz.1_Missense_Mutation_p.E623G|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.E625G|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	760							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGACAACTCCTCTTCCGGTGA	0.478			NA											20	23					0	0	0.00278	0	0
DCAF11	80344	broad.mit.edu	37	14	24588398	24588398	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:24588398C>G	uc001wlv.2	+	9	1104	c.824C>G	c.(823-825)TCA>TGA	p.S275*	DCAF11_uc001wlw.2_Nonsense_Mutation_p.S275*|DCAF11_uc001wlz.2_Nonsense_Mutation_p.S175*|DCAF11_uc001wly.2_Nonsense_Mutation_p.S231*|DCAF11_uc001wme.2_Nonsense_Mutation_p.S235*|DCAF11_uc010tny.1_Nonsense_Mutation_p.S142*|DCAF11_uc001wmd.2_Nonsense_Mutation_p.S275*|DCAF11_uc001wmc.2_Nonsense_Mutation_p.S175*|DCAF11_uc001wmb.3_Nonsense_Mutation_p.S249*|DCAF11_uc001wma.3_Nonsense_Mutation_p.S275*	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	275	WD 3.					CUL4 RING ubiquitin ligase complex	protein binding				0						GCTGTCTCCTCAGATGGACGA	0.478			NA											24	116					0	0	0.007291	0	0
AKAP6	9472	broad.mit.edu	37	14	33015208	33015208	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:33015208C>T	uc001wrq.2	+	4	1519	c.1349C>T	c.(1348-1350)TCT>TTT	p.S450F	AKAP6_uc010aml.2_Missense_Mutation_p.S447F	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	450					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AACAGCCCTTCTGCTGCCAGC	0.468	Melanoma(49;821 1200 7288 13647 42351)		NA											40	211					0	0	0.00361	0	0
SEC23A	10484	broad.mit.edu	37	14	39512034	39512034	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:39512034G>C	uc001wup.1	-	17	2165	c.1942C>G	c.(1942-1944)CTT>GTT	p.L648V	SEC23A_uc010tqa.1_Missense_Mutation_p.L534V|SEC23A_uc010tqb.1_Missense_Mutation_p.L619V	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	648					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TCCATGAGAAGAATACGATCT	0.328			NA											5	107					0	0	0.000602	0	0
LRFN5	145581	broad.mit.edu	37	14	42360560	42360560	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:42360560C>A	uc001wvm.2	+	4	2691	c.1493C>A	c.(1492-1494)ACT>AAT	p.T498N	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	498	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ACTTCCCTCACTGCCACAAGA	0.453			NA								HNSCC(30;0.082)			47	184					1.54886e-18	2.18574e-18	0.00361	1	0
LRFN5	145581	broad.mit.edu	37	14	42360851	42360851	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:42360851G>C	uc001wvm.2	+	4	2982	c.1784G>C	c.(1783-1785)GGA>GCA	p.G595A	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	595	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CAAGCTGTGGGACACGAAGAG	0.473			NA								HNSCC(30;0.082)			22	33					0	0	0.007291	0	0
FSCB	84075	broad.mit.edu	37	14	44975043	44975043	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:44975043T>C	uc001wvn.2	-	1	1457	c.1148A>G	c.(1147-1149)GAA>GGA	p.E383G		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	383	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGACCGAATTTCACCAAGAAG	0.527			NA											38	67					0	0	0.00361	0	0
NID2	22795	broad.mit.edu	37	14	52508850	52508850	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:52508850C>A	uc001wzo.2	-	7	2032	c.1798G>T	c.(1798-1800)GGC>TGC	p.G600C	NID2_uc010tqs.1_Missense_Mutation_p.G600C|NID2_uc010tqt.1_Missense_Mutation_p.G600C|NID2_uc001wzp.2_Missense_Mutation_p.G600C	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	600	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TTCTCAGAGCCAGGTTTTTCT	0.587			NA											20	61					3.51602e-12	4.52508e-12	0.008871	1	0
FERMT2	10979	broad.mit.edu	37	14	53385933	53385933	+	Missense_Mutation	SNP	C	C	A	rs141887548		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:53385933C>A	uc001xad.2	-	3	354	c.299G>T	c.(298-300)CGC>CTC	p.R100L	FERMT2_uc001xac.2_Missense_Mutation_p.R100L|FERMT2_uc001xae.2_Missense_Mutation_p.R100L|FERMT2_uc001xaf.2_Missense_Mutation_p.R100L	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	100					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					AAGCTGCAGGCGGAGCAGTTT	0.418			NA											35	96					2.45108e-15	3.3152e-15	0.00874	1	0
ACTN1	87	broad.mit.edu	37	14	69445737	69445737	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:69445737T>C	uc001xkl.2	-	1	347	c.37A>G	c.(37-39)ATG>GTG	p.M13V	ACTN1_uc010ttb.1_5'Flank|ACTN1_uc001xkm.2_Missense_Mutation_p.M13V|ACTN1_uc001xkn.2_Missense_Mutation_p.M13V|ACTN1_uc001xko.1_5'Flank|ACTN1_uc010ttd.1_5'Flank	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	13	Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCTGGCTGCATGTAATCGTTG	0.572			NA											30	50					0	0	0.004878	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634159	70634159	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:70634159G>C	uc001xly.2	-	2	1735	c.981C>G	c.(979-981)CAC>CAG	p.H327Q	SLC8A3_uc001xlw.2_Missense_Mutation_p.H327Q|SLC8A3_uc001xlx.2_Missense_Mutation_p.H327Q|SLC8A3_uc001xlz.2_Missense_Mutation_p.H327Q|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	327	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCTTCTCTGGGTGTTTTTGCT	0.512			NA											25	42					0	0	0.00632	0	0
ADAM20	8748	broad.mit.edu	37	14	70989767	70989767	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:70989767C>A	uc001xme.2	-	2	2103	c.1858G>T	c.(1858-1860)GGA>TGA	p.G620*		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	570	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GGAATTACTCCCACATTTTCA	0.453			NA											18	43					1.15919e-05	1.28955e-05	0.008871	1	0
FLVCR2	55640	broad.mit.edu	37	14	76107373	76107373	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:76107373C>A	uc001xrs.2	+	7	1687	c.1311C>A	c.(1309-1311)ATC>ATA	p.I437I	FLVCR2_uc010tvd.1_Silent_p.I232I	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	437	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		CAGAAGGCATCTCCTCCGGCC	0.502			NA											17	52					1.36565e-18	1.92988e-18	0.00278	1	0
TRIP11	9321	broad.mit.edu	37	14	92471799	92471799	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:92471799T>A	uc001xzy.2	-	11	3309	c.2521A>T	c.(2521-2523)AAT>TAT	p.N841Y	TRIP11_uc010auf.1_Missense_Mutation_p.N577Y	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	841	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		AAAATTTCATTTTTTCTTAAG	0.333	Ovarian(84;609 1888 9852 42686)		NA	T	PDGFRB	AML								11	19					0	0	0.001368	0	0
BCL11B	64919	broad.mit.edu	37	14	99640725	99640725	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:99640725C>A	uc001yga.2	-	4	2715	c.2448G>T	c.(2446-2448)CGG>CGT	p.R816R	BCL11B_uc001ygb.2_Silent_p.R745R	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	816	C2H2-type 4.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CGGTGTGGCTCCGCCGGTGCA	0.602			NA	T	TLX3	T-ALL								21	19					4.26978e-12	5.46727e-12	0.00333	1	0
WARS	7453	broad.mit.edu	37	14	100801274	100801274	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:100801274C>T	uc001yhf.1	-	10	1438	c.1354G>A	c.(1354-1356)GTC>ATC	p.V452I	WARS_uc001yhe.1_Missense_Mutation_p.V258I|WARS_uc001yhg.1_Missense_Mutation_p.V452I|WARS_uc001yhh.1_Missense_Mutation_p.V452I|WARS_uc001yhi.1_Missense_Mutation_p.V411I|WARS_uc001yhj.1_Missense_Mutation_p.V411I|WARS_uc001yhk.1_Missense_Mutation_p.V411I|WARS_uc001yhl.1_Missense_Mutation_p.V452I	NM_173701	NP_776049	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase isoform a	452					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	TCATCCGTGACCTCCTTGCGC	0.512			NA											10	84					0	0	0.008291	0	0
DLK1	8788	broad.mit.edu	37	14	101200499	101200499	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:101200499C>A	uc001yhs.3	+	5	571	c.418C>A	c.(418-420)CAC>AAC	p.H140N	DLK1_uc001yhu.3_Missense_Mutation_p.H140N	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	140	Extracellular (Potential).|EGF-like 4.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CCCCTGCCAGCACGGAGGCAC	0.647			NA											9	36					4.68919e-08	5.51444e-08	0.008291	1	0
DLK1	8788	broad.mit.edu	37	14	101201212	101201212	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:101201212G>A	uc001yhs.3	+	5	1284	c.1131G>A	c.(1129-1131)GAG>GAA	p.E377E	DLK1_uc001yhu.3_Silent_p.E304E	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	377	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				TCAGCAAGGAGGCCGGCGACG	0.547			NA											15	114					0	0	0.007413	0	0
C14orf180	400258	broad.mit.edu	37	14	105054091	105054091	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:105054091C>G	uc001yow.1	+	3	418	c.117C>G	c.(115-117)GAC>GAG	p.D39E	C14orf180_uc010tyh.1_Missense_Mutation_p.D39E|C14orf180_uc010awy.1_Missense_Mutation_p.D39E	NM_001008404	NP_001008404	Q8N912	CN180_HUMAN	hypothetical protein LOC400258	39						integral to membrane					0		Melanoma(154;0.226)	all cancers(16;0.00405)|OV - Ovarian serous cystadenocarcinoma(23;0.0319)|Epithelial(46;0.0784)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.127)		ACCAGGAGGACAACAGGAAGT	0.701			NA											3	15					0	0	0.004672	0	0
CYFIP1	23191	broad.mit.edu	37	15	22963800	22963800	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:22963800G>T	uc001yus.2	+	21	2418	c.2314G>T	c.(2314-2316)GTC>TTC	p.V772F	CYFIP1_uc001yut.2_Missense_Mutation_p.V772F|CYFIP1_uc010aya.1_Missense_Mutation_p.V800F|CYFIP1_uc001yuu.2_Missense_Mutation_p.V341F	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	772					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CACCCAGCGCGTCTCAGCAGC	0.478			NA											44	31					1.51926e-22	2.23785e-22	0.00361	1	0
GABRB3	2562	broad.mit.edu	37	15	26806080	26806080	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:26806080C>A	uc001zaz.2	-	8	1221	c.1079G>T	c.(1078-1080)CGG>CTG	p.R360L	GABRB3_uc010uae.1_Missense_Mutation_p.R275L|GABRB3_uc001zba.2_Missense_Mutation_p.R360L|GABRB3_uc001zbb.2_Missense_Mutation_p.R416L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	360	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGAGCCTACCCGGTTGCTTTC	0.478			NA											47	76					6.56871e-35	1.02757e-34	0.00361	1	0
TRPM1	4308	broad.mit.edu	37	15	31319284	31319284	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:31319284C>A	uc001zfm.2	-	25	3392	c.3264G>T	c.(3262-3264)CAG>CAT	p.Q1088H	TRPM1_uc010azy.2_Missense_Mutation_p.Q995H|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1088	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACTTCCACACCTGGTTGGATA	0.368			NA											20	32					1.55469e-16	2.14301e-16	0.00333	1	0
TRPM1	4308	broad.mit.edu	37	15	31354895	31354895	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:31354895C>A	uc001zfm.2	-	8	1038	c.910G>T	c.(910-912)GAG>TAG	p.E304*	TRPM1_uc010azy.2_Nonsense_Mutation_p.E211*|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	304	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTGAGGGACTCATTTATTATT	0.333			NA											17	13					4.63292e-17	6.42118e-17	0.008871	1	0
ACTC1	70	broad.mit.edu	37	15	35085482	35085482	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:35085482C>A	uc001ziu.1	-	3	661	c.418G>T	c.(418-420)GCA>TCA	p.A140S	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	140					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GATAGCACTGCCTGGATGGCC	0.552			NA											14	73					3.45872e-05	3.80572e-05	0.004007	1	0
PLCB2	5330	broad.mit.edu	37	15	40582792	40582792	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:40582792C>A	uc001zld.2	-	29	3496	c.3195G>T	c.(3193-3195)AAG>AAT	p.K1065N	PLCB2_uc001zlc.2_Missense_Mutation_p.K49N|PLCB2_uc010bbo.2_Missense_Mutation_p.K1061N|PLCB2_uc010ucm.1_Missense_Mutation_p.K1050N	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	1065	Potential.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CCTGGGCCATCTTGTCTGTGG	0.567			NA											125	95					9.91784e-70	1.62453e-69	0.00361	1	0
FRMD5	84978	broad.mit.edu	37	15	44175919	44175919	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:44175919G>C	uc001ztl.2	-	13	1294	c.1117C>G	c.(1117-1119)CAC>GAC	p.H373D	FRMD5_uc001ztj.1_Missense_Mutation_p.H46D|FRMD5_uc001ztk.1_Missense_Mutation_p.H279D|FRMD5_uc010uef.1_Missense_Mutation_p.H46D|FRMD5_uc001ztm.2_Missense_Mutation_p.H46D|FRMD5_uc001ztn.2_Missense_Mutation_p.H139D	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	373						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		ATGGAGATGTGAACAGCTCTT	0.547			NA											26	73					0	0	0.003755	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056403	48056403	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:48056403T>A	uc010bek.2	+	11	1358	c.998T>A	c.(997-999)ATG>AAG	p.M333K	SEMA6D_uc001zvw.2_Missense_Mutation_p.M333K|SEMA6D_uc001zvx.1_Missense_Mutation_p.M333K|SEMA6D_uc001zvy.2_Missense_Mutation_p.M333K|SEMA6D_uc001zvz.2_Missense_Mutation_p.M333K|SEMA6D_uc001zwa.2_Missense_Mutation_p.M333K|SEMA6D_uc001zwb.2_Missense_Mutation_p.M333K|SEMA6D_uc001zwc.2_Missense_Mutation_p.M333K	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	333	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GCATTTAGCATGGATGACATT	0.458			NA											13	50					0	0	0.003163	0	0
MYEF2	50804	broad.mit.edu	37	15	48459593	48459593	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:48459593C>G	uc001zwi.3	-	3	500	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	MYEF2_uc001zwj.3_Missense_Mutation_p.E126Q|MYEF2_uc001zwl.2_Intron	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	126	RRM 1.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TATGTAACCTCACCAACTACA	0.403			NA											3	56					0	0	0.001168	0	0
ATP8B4	79895	broad.mit.edu	37	15	50168682	50168682	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:50168682G>T	uc001zxu.2	-	25	2962	c.2820C>A	c.(2818-2820)CTC>CTA	p.L940L	ATP8B4_uc010ber.2_Silent_p.L813L|ATP8B4_uc010ufd.1_Silent_p.L750L|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_5'UTR	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	940	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTGGTTTGTAGAGCTGGGGAC	0.428			NA											28	76					1.22384e-17	1.70795e-17	0.002836	1	0
AP4E1	23431	broad.mit.edu	37	15	51285706	51285706	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:51285706G>T	uc001zyx.1	+	17	2260	c.2230G>T	c.(2230-2232)GCT>TCT	p.A744S		NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	744					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TGTAGATCAAGCTATAACTAA	0.408			NA											4	32					0.00909568	0.00941286	0.009096	1	0
RAB27A	5873	broad.mit.edu	37	15	55516109	55516109	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:55516109T>C	uc002aco.2	-	6	678	c.445A>G	c.(445-447)ATA>GTA	p.I149V	RAB27A_uc002acr.2_Missense_Mutation_p.I149V|RAB27A_uc002acp.2_Missense_Mutation_p.I149V|RAB27A_uc002acq.2_Missense_Mutation_p.I149V	NM_183234	NP_899057	P51159	RB27A_HUMAN	Ras-related protein Rab-27A	149					small GTPase mediated signal transduction	dendrite|exocytic vesicle|late endosome|lysosome|melanosome	GTP binding|GTPase activity			ovary(1)	1				all cancers(107;0.0273)|GBM - Glioblastoma multiforme(80;0.0993)		GCGAGTGCTATGGCTTCCTCC	0.398			NA											72	189					0	0	0.00361	0	0
PYGO1	26108	broad.mit.edu	37	15	55839204	55839204	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:55839204G>A	uc010bfl.1	-	3	333	c.277C>T	c.(277-279)CCT>TCT	p.P93S	PYGO1_uc002adf.1_Missense_Mutation_p.P93S	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	93	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GGATAACCAGGGCCAAGATAT	0.438			NA											23	120					0	0	0.009535	0	0
NEDD4	4734	broad.mit.edu	37	15	56140574	56140574	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:56140574C>A	uc002adj.2	-	13	3095	c.2795G>T	c.(2794-2796)GGA>GTA	p.G932V	NEDD4_uc002adl.2_Missense_Mutation_p.G513V|NEDD4_uc002adi.2_Missense_Mutation_p.G860V|NEDD4_uc010ugj.1_Missense_Mutation_p.G916V|NEDD4_uc010bfm.2_Missense_Mutation_p.G915V|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	932	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		ACTTACTGGTCCAGTTATTGC	0.438			NA											72	175					6.20368e-34	9.68965e-34	0.00361	1	0
LIPC	3990	broad.mit.edu	37	15	58840561	58840561	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:58840561C>T	uc010bga.1	+	8	1449	c.841C>T	c.(841-843)CGA>TGA	p.R281*	LIPC_uc010bfz.1_Nonsense_Mutation_p.R281*|LIPC_uc002afa.1_Nonsense_Mutation_p.R281*|LIPC_uc010bgb.1_Nonsense_Mutation_p.R179*|LIPC_uc010ugy.1_Nonsense_Mutation_p.R220*	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	281					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		CTCCCACGAGCGATCGGTGCA	0.572			NA											13	135					0	0	0.007413	0	0
RORA	6095	broad.mit.edu	37	15	60795032	60795032	+	Silent	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:60795032A>C	uc002agv.2	-	9	1365	c.1209T>G	c.(1207-1209)CGT>CGG	p.R403R	uc002ags.1_Intron|RORA_uc002agt.3_Silent_p.R315R|RORA_uc002agw.2_Silent_p.R395R|RORA_uc002agx.2_Silent_p.R370R	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	403	Ligand-binding.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AGTCAAAGGCACGGCACATTC	0.458			NA											77	236					0	0	0.00361	0	0
CLPX	10845	broad.mit.edu	37	15	65450964	65450964	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:65450964C>A	uc002aom.2	-	7	913	c.841G>T	c.(841-843)GAC>TAC	p.D281Y	CLPX_uc010uiu.1_Intron|CLPX_uc010bhg.1_Missense_Mutation_p.D281Y	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	281					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						AGTTTTATGTCATCATGAGAA	0.353			NA											17	117					2.4624e-09	2.99344e-09	0.008871	1	0
IGDCC4	57722	broad.mit.edu	37	15	65684477	65684477	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:65684477T>A	uc002aou.1	-	11	2327	c.2117A>T	c.(2116-2118)CAG>CTG	p.Q706L	IGDCC4_uc002aot.1_Missense_Mutation_p.Q294L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	706	Extracellular (Potential).|Fibronectin type-III 3.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						CTCACCTAGCTGGGTCAGCTC	0.607			NA											18	123					0	0	0.008871	0	0
ANP32A	8125	broad.mit.edu	37	15	69072434	69072434	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:69072434C>G	uc002arl.2	-	7	907	c.736G>C	c.(736-738)GAA>CAA	p.E246Q		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	246	Interaction with E4F1 (By similarity).|Asp/Glu-rich (highly acidic).				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						TCATCATCTTCTCCCTCATCT	0.418			NA											7	60					0	0	0.006214	0	0
LOC645752	645752	broad.mit.edu	37	15	78207594	78207594	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:78207594C>G	uc010bky.2	-	18	2082	c.1318G>C	c.(1318-1320)GGT>CGT	p.G440R	LOC645752_uc010umq.1_Missense_Mutation_p.G87R|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TGGGGAGAACCCTCCCTGGCC	0.592			NA											38	11					0	0	0.00874	0	0
CHRNA3	1136	broad.mit.edu	37	15	78888978	78888978	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:78888978G>C	uc002bec.2	-	6	1672	c.1486C>G	c.(1486-1488)CTG>GTG	p.L496V	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Intron|CHRNA3_uc010blg.1_RNA	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	496	Helical; (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						AGGGGTTGCAGAAACAATCCT	0.498			NA											35	72					0	0	0.005524	0	0
TMC3	342125	broad.mit.edu	37	15	81635632	81635633	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:81635632_81635633GG>TT	uc002bgo.1	-	15	1701_1702	c.1701_1702CC>AA	c.(1699-1704)AACCAA>AAAAAA	p.567_568NQ>KK	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Missense_Mutation_p.567_568NQ>KK	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	567_568	Extracellular (Potential).					integral to membrane				ovary(1)|liver(1)	2						ATCATTCCTTGGTTGTAGACTA	0.351			NA											16	69					0	0	0.004672	0	0
CPEB1	64506	broad.mit.edu	37	15	83226530	83226530	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:83226530C>A	uc002bit.2	-	4	903	c.766G>T	c.(766-768)GAT>TAT	p.D256Y	CPEB1_uc002biq.2_Missense_Mutation_p.D121Y|CPEB1_uc002bir.2_Missense_Mutation_p.D121Y|CPEB1_uc002bis.2_Missense_Mutation_p.D121Y|CPEB1_uc010uod.1_Intron|CPEB1_uc010uoe.1_Missense_Mutation_p.D199Y|CPEB1_uc002biu.2_Missense_Mutation_p.D223Y|CPEB1_uc010uof.1_Missense_Mutation_p.D121Y|CPEB1_uc002biv.2_Missense_Mutation_p.D196Y|CPEB1_uc002bip.2_5'Flank	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	196	Ser-rich.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GAGAGATGATCTGATCCAGAG	0.522			NA											22	94					8.24728e-16	1.12301e-15	0.004656	1	0
ALPK3	57538	broad.mit.edu	37	15	85399757	85399757	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:85399757G>A	uc002ble.2	+	6	2561	c.2394G>A	c.(2392-2394)GGG>GGA	p.G798G		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	798					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGGAGGATGGGAGAACATCTG	0.512			NA											12	61					0	0	0.001368	0	0
ACAN	176	broad.mit.edu	37	15	89383370	89383370	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:89383370C>G	uc010upo.1	+	4	956	c.582C>G	c.(580-582)GAC>GAG	p.D194E	ACAN_uc002bmx.2_Missense_Mutation_p.D194E|ACAN_uc010upp.1_Missense_Mutation_p.D194E|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	194					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTACGAAGACGGCTTCCACC	0.647			NA											3	19					0	0	0.009096	0	0
ACAN	176	broad.mit.edu	37	15	89398664	89398664	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:89398664G>A	uc010upo.1	+	12	3222	c.2848G>A	c.(2848-2850)GGA>AGA	p.G950R	ACAN_uc010upp.1_Missense_Mutation_p.G950R|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	950					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTCTGCCTCTGGAGTTGGGGA	0.547			NA											29	42					0	0	0.008361	0	0
WDR93	56964	broad.mit.edu	37	15	90255262	90255262	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:90255262T>C	uc002boj.2	+	5	668	c.567T>C	c.(565-567)GAT>GAC	p.D189D	WDR93_uc010bnr.2_Silent_p.D189D	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	189					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TTCAGGATGATACCAGCAAGC	0.448			NA											10	54					0	0	0.001368	0	0
SV2B	9899	broad.mit.edu	37	15	91801761	91801761	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:91801761G>C	uc002bqv.2	+	4	1286	c.895G>C	c.(895-897)GAG>CAG	p.E299Q	SV2B_uc002bqt.2_Missense_Mutation_p.E299Q|SV2B_uc010uqv.1_Missense_Mutation_p.E148Q|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	299	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GTTCATGCCAGAGAGCCCAAG	0.552			NA											9	121					0	0	0.006214	0	0
OR4F6	390648	broad.mit.edu	37	15	102346129	102346129	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr15:102346129C>G	uc010utr.1	+	1	207	c.207C>G	c.(205-207)ATC>ATG	p.I69M		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTTCCATCATCAATTTGGTAT	0.463			NA											10	331					0	0	0.001368	0	0
RGS11	8786	broad.mit.edu	37	16	321090	321090	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:321090G>T	uc002cgj.1	-	13	875	c.872C>A	c.(871-873)GCC>GAC	p.A291D	RGS11_uc002cgi.1_Missense_Mutation_p.A270D|RGS11_uc010bqs.1_Missense_Mutation_p.A280D|RGS11_uc002cgk.1_Missense_Mutation_p.A107D	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	291					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CTTCGTGGGGGCAGCCACCCT	0.701			NA											4	19					0.00116845	0.00123451	0.001168	1	0
MSLN	10232	broad.mit.edu	37	16	814656	814656	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:814656C>G	uc002cjw.1	+	6	361	c.310C>G	c.(310-312)CTG>GTG	p.L104V	MSLN_uc002cjt.1_Missense_Mutation_p.L104V|MSLN_uc002cju.1_Missense_Mutation_p.L104V|MSLN_uc010brd.1_Missense_Mutation_p.L103V|MSLN_uc002cjv.1_Missense_Mutation_p.L104V|MSLN_uc002cjx.1_Missense_Mutation_p.L104V|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	104					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GCTGCGCTGTCTGGCTCACCG	0.677			NA											27	267					0	0	0.009535	0	0
SOX8	30812	broad.mit.edu	37	16	1035263	1035263	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:1035263C>A	uc002ckn.2	+	3	1333	c.1218C>A	c.(1216-1218)CCC>CCA	p.P406P		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	406					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				ACCAGTACCCCTGCTTCCACT	0.672			NA											27	31					1.06647e-15	1.44828e-15	0.003755	1	0
ABCA3	21	broad.mit.edu	37	16	2369608	2369608	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:2369608C>G	uc002cpy.1	-	8	1559	c.847G>C	c.(847-849)GTG>CTG	p.V283L	ABCA3_uc010bsk.1_Missense_Mutation_p.V283L|ABCA3_uc010bsl.1_Missense_Mutation_p.V283L	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	283	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TTCTCCTGCACGACAGCACGG	0.612			NA											10	99					0	0	0.000978	0	0
PDPK1	5170	broad.mit.edu	37	16	2647754	2647754	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:2647754G>C	uc002cqs.2	+	14	1801	c.1657G>C	c.(1657-1659)GCC>CCC	p.A553P	PDPK1_uc002cqt.2_Missense_Mutation_p.A426P|PDPK1_uc010bsn.2_3'UTR|PDPK1_uc002cqu.2_Missense_Mutation_p.A526P	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	553					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	CCACCCGGACGCCGCTGTGCA	0.657			NA											7	35					0	0	0.008291	0	0
NMRAL1	57407	broad.mit.edu	37	16	4511851	4511851	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:4511851C>G	uc002cwm.2	-	6	986	c.830G>C	c.(829-831)AGA>ACA	p.R277T	NMRAL1_uc002cwn.2_Missense_Mutation_p.R277T|NMRAL1_uc002cwo.2_Missense_Mutation_p.R277T|NMRAL1_uc002cwp.2_Missense_Mutation_p.R313T	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	277						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						GGGGTTGAGTCTCAGGGTCAG	0.617			NA											24	166					0	0	0.009535	0	0
NMRAL1	57407	broad.mit.edu	37	16	4511958	4511958	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:4511958C>T	uc002cwm.2	-	6	879	c.723G>A	c.(721-723)ATG>ATA	p.M241I	NMRAL1_uc002cwn.2_Missense_Mutation_p.M241I|NMRAL1_uc002cwo.2_Missense_Mutation_p.M241I|NMRAL1_uc002cwp.2_Missense_Mutation_p.M277I	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	241						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						CCTCAGGAGTCATCTGGAAGC	0.652			NA											17	106					0	0	0.007413	0	0
GLYR1	84656	broad.mit.edu	37	16	4882010	4882010	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:4882010C>T	uc002cxx.3	-	5	544	c.507G>A	c.(505-507)CGG>CGA	p.R169R	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Silent_p.R100R|GLYR1_uc002cya.2_Silent_p.R169R|GLYR1_uc010uxv.1_Intron	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	169	A.T hook.				pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						GACCCCGCTTCCGGGGACTTT	0.498			NA											9	50					0	0	0.006214	0	0
USP7	7874	broad.mit.edu	37	16	8993541	8993541	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:8993541C>T	uc002czl.2	-	22	2582	c.2383G>A	c.(2383-2385)GAT>AAT	p.D795N	USP7_uc010uyk.1_Missense_Mutation_p.D696N|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.D696N|USP7_uc002czk.2_Missense_Mutation_p.D779N	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	795	Interaction with ICP0/VMW110.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						AAAATGACATCAACGCGGTGG	0.388			NA											14	98					0	0	0.001855	0	0
GRIN2A	2903	broad.mit.edu	37	16	9928037	9928037	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:9928037C>A	uc002czo.3	-	8	2250	c.1702G>T	c.(1702-1704)GTT>TTT	p.V568F	GRIN2A_uc010uym.1_Missense_Mutation_p.V568F|GRIN2A_uc010uyn.1_Missense_Mutation_p.V411F|GRIN2A_uc002czr.3_Missense_Mutation_p.V568F	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	568	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGGCAGAAACAATGAGCAGC	0.418			NA											16	103					8.00594e-06	8.95565e-06	0.007413	1	0
PDXDC1	23042	broad.mit.edu	37	16	15095657	15095657	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:15095657C>G	uc002dda.3	+	4	410	c.186C>G	c.(184-186)CTC>CTG	p.L62L	PDXDC1_uc010uzl.1_Silent_p.L47L|PDXDC1_uc010uzm.1_Intron|PDXDC1_uc010bvc.1_5'UTR|PDXDC1_uc002dcz.2_Silent_p.L62L|PDXDC1_uc002ddb.3_Intron|PDXDC1_uc010uzn.1_Intron|PDXDC1_uc002ddc.2_Silent_p.L62L	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	62					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TGAGCATCCTCCAGTTAGTTC	0.498			NA											4	30					0	0	0.000602	0	0
MYH11	4629	broad.mit.edu	37	16	15829353	15829353	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:15829353C>A	uc002ddy.2	-	26	3483	c.3376G>T	c.(3376-3378)GAC>TAC	p.D1126Y	MYH11_uc002ddv.2_Missense_Mutation_p.D1133Y|MYH11_uc002ddw.2_Missense_Mutation_p.D1126Y|MYH11_uc002ddx.2_Missense_Mutation_p.D1133Y|MYH11_uc010bvg.2_Missense_Mutation_p.D958Y	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1126	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAGTCCAGGTCCTCCTGGAGG	0.582			NA	T	CBFB	AML								17	151					3.10358e-05	3.42242e-05	0.002299	1	0
DNAH3	55567	broad.mit.edu	37	16	21080738	21080738	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:21080738C>T	uc010vbe.1	-	23	3379	c.3379G>A	c.(3379-3381)GCG>ACG	p.A1127T		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1127	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AAACTTACCGCTTGGGACATA	0.393			NA											35	54					0	0	0.003214	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926860	22926860	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:22926860G>T	uc002dli.2	+	2	1153	c.1081G>T	c.(1081-1083)GGG>TGG	p.G361W	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	361	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		TGAAACCGTTGGGCAGGACTT	0.448			NA											46	33					7.47603e-22	1.09323e-21	0.00361	1	0
ERN2	10595	broad.mit.edu	37	16	23713983	23713983	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:23713983C>T	uc002dma.3	-	9	1208	c.1039G>A	c.(1039-1041)GTC>ATC	p.V347I	ERN2_uc010bxp.2_Missense_Mutation_p.V347I|ERN2_uc010bxq.1_Missense_Mutation_p.V155I	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	299	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCTTTAGAGACATAGAAGCCA	0.488			NA											20	53					0	0	0.005443	0	0
LCMT1	51451	broad.mit.edu	37	16	25175934	25175934	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:25175934G>C	uc002dnx.1	+	7	743	c.585G>C	c.(583-585)CTG>CTC	p.L195L	LCMT1_uc002dny.1_Silent_p.L140L|LCMT1_uc002dnz.1_Silent_p.L95L|LCMT1_uc002doa.1_Silent_p.L40L	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	195							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CAACACTCCTGATAGCTGAAT	0.428	Colon(200;565 2072 24396 47922 50898)		NA											8	30					0	0	0.006214	0	0
IL4R	3566	broad.mit.edu	37	16	27370278	27370278	+	Missense_Mutation	SNP	G	G	T	rs55988941	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:27370278G>T	uc002don.2	+	9	1054	c.812G>T	c.(811-813)CGC>CTC	p.R271L	IL4R_uc002dop.3_Missense_Mutation_p.R256L|IL4R_uc010bxy.2_Missense_Mutation_p.R271L|IL4R_uc002doo.2_Missense_Mutation_p.R111L	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	271	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						AACCCAGCCCGCAGCCGCCTC	0.478			NA											16	44					2.48551e-13	3.24854e-13	0.00499	1	0
IL21R	50615	broad.mit.edu	37	16	27454428	27454428	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:27454428C>A	uc002doq.1	+	5	731	c.498C>A	c.(496-498)CCC>CCA	p.P166P	IL21R_uc002dor.1_Silent_p.P166P|IL21R_uc002dos.1_Silent_p.P166P	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	166	Extracellular (Potential).|Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGGGAGACCCCTGGGCTGTGG	0.557			NA	T	BCL6	NHL								13	31					0.000308642	0.000332713	0.003163	1	0
IL27	246778	broad.mit.edu	37	16	28515207	28515207	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:28515207G>T	uc002dqc.2	-	2	219	c.196C>A	c.(196-198)CAC>AAC	p.H66N	uc010vct.1_Intron	NM_145659	NP_663634	Q8NEV9	IL27A_HUMAN	interleukin 27 precursor	66					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding				0						ACAAAGCGGTGGGCCTGGCCC	0.657			NA											22	54					1.17739e-12	1.51917e-12	0.005443	1	0
RUNDC2C	440352	broad.mit.edu	37	16	29376190	29376190	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:29376190G>A	uc002dsj.1	+	5	929	c.532G>A	c.(532-534)GGG>AGG	p.G178R	uc010vct.1_Intron|RUNDC2C_uc010bys.1_RNA|RUNDC2C_uc010vdo.1_Missense_Mutation_p.G159R	NM_001012391	NP_001012391			RecName: Full=RUN domain-containing protein 2A;												0						AAGCCCCTTCGGGCCAAACTC	0.498			NA											13	71					0	0	0.007413	0	0
ZNF646	9726	broad.mit.edu	37	16	31090321	31090321	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:31090321G>C	uc002eap.2	+	2	2965	c.2676G>C	c.(2674-2676)GGG>GGC	p.G892G		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	892	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TCTTCCCTGGGCGGGCTGGCT	0.652			NA											19	53					0	0	0.001882	0	0
ITGAD	3681	broad.mit.edu	37	16	31434720	31434720	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:31434720G>T	uc002ebv.1	+	25	2956	c.2907G>T	c.(2905-2907)TGG>TGT	p.W969C	ITGAD_uc010cap.1_Missense_Mutation_p.W970C	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	969	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TTAACTTCTGGGTTCCTGTCC	0.537			NA											41	74					3.16986e-14	4.20841e-14	0.00361	1	0
ABCC12	94160	broad.mit.edu	37	16	48134857	48134857	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:48134857G>A	uc002efc.1	-	21	3310	c.2964C>T	c.(2962-2964)TTC>TTT	p.F988F	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	988	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TGATGTGGGTGAACCAGGGTG	0.572			NA											6	44					0	0	0.006214	0	0
CBLN1	869	broad.mit.edu	37	16	49313338	49313338	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:49313338C>G	uc002efq.2	-	3	898	c.559G>C	c.(559-561)GGA>CGA	p.G187R		NM_004352	NP_004343	P23435	CBLN1_HUMAN	cerebellin 1 precursor	187	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).				nervous system development|synaptic transmission	cell junction|extracellular region|synapse					0		all_cancers(37;0.0766)|all_lung(18;0.24)				ACCAGGAATCCGGAGAAGGTC	0.567			NA											10	100					0	0	0.001368	0	0
CYLD	1540	broad.mit.edu	37	16	50813605	50813606	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:50813605_50813606GA>TT	uc002egp.1	+	9	1583_1584	c.1168_1169GA>TT	c.(1168-1170)GAG>TTG	p.E390L	CYLD_uc002ego.2_Missense_Mutation_p.E387L|CYLD_uc010cbs.1_Missense_Mutation_p.E387L|CYLD_uc002egq.1_Missense_Mutation_p.E387L|CYLD_uc002egr.1_Missense_Mutation_p.E387L|CYLD_uc002egs.1_Missense_Mutation_p.E387L	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	390	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				ATCTCTTACAGAGATATCTACA	0.386			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				21	163					0	0	0.004672	0	0
MMP2	4313	broad.mit.edu	37	16	55519646	55519646	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:55519646C>A	uc002ehz.3	+	5	1100	c.789C>A	c.(787-789)TAC>TAA	p.Y263*	MMP2_uc010vhd.1_Nonsense_Mutation_p.Y187*|MMP2_uc010ccc.2_Nonsense_Mutation_p.Y213*	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	263	Fibronectin type-II 1.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CCACCACCTACAACTTTGAGA	0.562			NA											15	134					4.96729e-08	5.83469e-08	0.008871	1	0
GNAO1	2775	broad.mit.edu	37	16	56226490	56226490	+	Silent	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:56226490T>A	uc002eit.3	+	2	1020	c.123T>A	c.(121-123)GCT>GCA	p.A41A	GNAO1_uc002eiu.3_Silent_p.A41A|LOC283856_uc002eis.1_5'Flank	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	41	GTP (By similarity).				dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CAACAGGGGCTGGAGAATCAG	0.478			NA											21	134					0	0	0.00632	0	0
GPR114	221188	broad.mit.edu	37	16	57597831	57597831	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:57597831G>T	uc002elx.3	+	5	454	c.369G>T	c.(367-369)AAG>AAT	p.K123N	GPR114_uc010vhr.1_Missense_Mutation_p.K123N|GPR114_uc002ely.2_Missense_Mutation_p.K123N	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	123	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						ACGCCTGCAAGACCCGCCCCA	0.647			NA											7	81					2.17888e-05	2.40535e-05	0.006214	1	0
CNOT1	23019	broad.mit.edu	37	16	58559111	58559111	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:58559111C>G	uc002env.2	-	46	7049	c.6756G>C	c.(6754-6756)CAG>CAC	p.Q2252H	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.Q2247H|CNOT1_uc002ent.2_Missense_Mutation_p.Q190H|CNOT1_uc010vik.1_Missense_Mutation_p.Q1209H	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAGCCAAATTCTGGAAGATAT	0.478			NA											17	134					0	0	0.001882	0	0
CNOT1	23019	broad.mit.edu	37	16	58564242	58564242	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:58564242T>C	uc002env.2	-	43	6480	c.6187A>G	c.(6187-6189)ATG>GTG	p.M2063V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.M2058V|CNOT1_uc002ent.2_Missense_Mutation_p.M1V|CNOT1_uc010vik.1_Missense_Mutation_p.M1020V	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2063					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGTGCATACATAGGCCACCCC	0.388			NA											11	60					0	0	0.000978	0	0
LRRC36	55282	broad.mit.edu	37	16	67401279	67401279	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:67401279G>A	uc002esv.2	+	8	1133	c.1114G>A	c.(1114-1116)GCT>ACT	p.A372T	LRRC36_uc002esw.2_Intron|LRRC36_uc010ceh.2_Intron|LRRC36_uc002esx.2_Missense_Mutation_p.A251T|LRRC36_uc010vjk.1_Missense_Mutation_p.A251T|LRRC36_uc010vjl.1_Intron|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	372											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		AAAGACCACCGCTTCACATTC	0.433			NA											31	175					0	0	0.004878	0	0
FAM65A	79567	broad.mit.edu	37	16	67576587	67576587	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:67576587C>A	uc010vjp.1	+	13	2054	c.1958C>A	c.(1957-1959)ACC>AAC	p.T653N	FAM65A_uc010cei.1_Missense_Mutation_p.T475N|FAM65A_uc002eth.2_Missense_Mutation_p.T633N|FAM65A_uc010cej.2_Missense_Mutation_p.T636N|FAM65A_uc002eti.1_Missense_Mutation_p.T596N|FAM65A_uc010vjq.1_Missense_Mutation_p.T647N|FAM65A_uc002etj.1_Missense_Mutation_p.T632N|FAM65A_uc002etk.2_Missense_Mutation_p.T632N	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	637	Pro-rich.					cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		ACCCACAAAACCAGTATGTCA	0.582			NA											69	122					3.12118e-38	4.93617e-38	0.00361	1	0
PKD1L2	114780	broad.mit.edu	37	16	81185474	81185474	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:81185474T>C	uc002fgh.1	-	27	4451	c.4451A>G	c.(4450-4452)AAG>AGG	p.K1484R	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1484	Cytoplasmic (Potential).|PLAT.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GAAATACCACTTCCGGTCCAT	0.527			NA											4	35					0	0	0.009096	0	0
PKD1L2	114780	broad.mit.edu	37	16	81194295	81194295	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:81194295C>T	uc002fgh.1	-	22	3693	c.3693G>A	c.(3691-3693)GTG>GTA	p.V1231V	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1231	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TACCTGGAGCCACCATTGGTA	0.517			NA											5	20					0	0	0.00308	0	0
KCNG4	93107	broad.mit.edu	37	16	84270421	84270421	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:84270421G>C	uc010voc.1	-	2	792	c.671C>G	c.(670-672)GCT>GGT	p.A224G	KCNG4_uc002fhu.1_Missense_Mutation_p.A224G	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	224						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						GGAGAGGCAAGCGAAGACCTT	0.682			NA											15	63					0	0	0.008871	0	0
COX4I1	1327	broad.mit.edu	37	16	85838698	85838698	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:85838698G>T	uc002fje.2	+	3	393	c.229G>T	c.(229-231)GAG>TAG	p.E77*	COX4I1_uc002fjf.2_Nonsense_Mutation_p.E77*|COX4I1_uc002fjg.1_Nonsense_Mutation_p.E77*|COX4I1_uc010vom.1_5'UTR	NM_001861	NP_001852	P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	77					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			lung(1)	1		Renal(780;0.228)				CTCCATGGATGAGAAAGTCGA	0.602			NA											4	31					0.00909568	0.00941286	0.009096	1	0
IRF8	3394	broad.mit.edu	37	16	85936643	85936643	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:85936643C>A	uc002fjh.2	+	2	79	c.22C>A	c.(22-24)CGG>AGG	p.R8R	IRF8_uc002fji.2_Silent_p.R8R	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	8	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				GAATGGTGGTCGGCGGCTTCG	0.478			NA											59	160					3.12118e-38	4.93617e-38	0.00361	1	0
ANKRD11	29123	broad.mit.edu	37	16	89352509	89352509	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:89352509G>A	uc002fmx.1	-	8	1291	c.830C>T	c.(829-831)CCC>CTC	p.P277L	ANKRD11_uc002fmy.1_Missense_Mutation_p.P277L|ANKRD11_uc002fnc.1_Missense_Mutation_p.P277L|ANKRD11_uc002fnb.1_Missense_Mutation_p.P234L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	277	ANK 4.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CACCATCGTGGGGGAGTTGGC	0.577			NA											48	121					0	0	0.00361	0	0
NXN	64359	broad.mit.edu	37	17	725687	725687	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:725687C>A	uc002fsa.2	-	4	715	c.623G>T	c.(622-624)TGC>TTC	p.C208F	NXN_uc002fsb.1_Missense_Mutation_p.C95F|NXN_uc010vqd.1_5'UTR|NXN_uc002frz.2_5'UTR|NXN_uc010vqe.1_Missense_Mutation_p.C100F	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	208	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		GAGGCTTCGGCAGGGCGGACA	0.592			NA											70	8					9.25274e-37	1.45875e-36	0.00361	1	0
OR3A4	390756	broad.mit.edu	37	17	3213766	3213766	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:3213766G>T	uc002fvi.2	+	1	228	c.162G>T	c.(160-162)ATG>ATT	p.M54I		NR_024128				RecName: Full=Olfactory receptor 3A4; AltName: Full=Olfactory receptor 17-24;          Short=OR17-24;											ovary(1)	1						CCATCCTTATGGAAACCAAAC	0.542			NA											74	28					7.68447e-34	1.1984e-33	0.00361	1	0
NLRP1	22861	broad.mit.edu	37	17	5462625	5462625	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:5462625T>G	uc002gci.2	-	4	1946	c.1391A>C	c.(1390-1392)CAG>CCG	p.Q464P	NLRP1_uc002gcg.1_Missense_Mutation_p.Q464P|NLRP1_uc002gck.2_Missense_Mutation_p.Q464P|NLRP1_uc002gcj.2_Missense_Mutation_p.Q464P|NLRP1_uc002gcl.2_Missense_Mutation_p.Q464P|NLRP1_uc002gch.3_Missense_Mutation_p.Q464P|NLRP1_uc010clh.2_Missense_Mutation_p.Q464P	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	464	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				AATGAGGTTCTGCAGAGCTGT	0.537			NA											14	8					0	0	0.001855	0	0
BCL6B	255877	broad.mit.edu	37	17	6930310	6930310	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:6930310G>A	uc002geg.2	+	8	1284	c.1227G>A	c.(1225-1227)GAG>GAA	p.E409E	BCL6B_uc010clt.1_Silent_p.E410E	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	409						nucleus	zinc ion binding			skin(1)	1						ACACCGGGGAGAAGCCCTACC	0.632			NA											27	54					0	0	0.008361	0	0
PHF23	79142	broad.mit.edu	37	17	7139465	7139465	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:7139465C>T	uc002gfa.2	-	4	1008	c.781G>A	c.(781-783)GAG>AAG	p.E261K	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Missense_Mutation_p.E194K|PHF23_uc010cma.2_Missense_Mutation_p.E131K	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	261	Poly-Glu.						zinc ion binding				0						GTTGCCATCtcttcttcttct	0.522			NA											14	64					0	0	0.00245	0	0
AMAC1L3	643664	broad.mit.edu	37	17	7385378	7385378	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:7385378C>A	uc010cmj.1	+	2	190	c.75C>A	c.(73-75)CTC>CTA	p.L25L	ZBTB4_uc002ghc.3_5'Flank|ZBTB4_uc002ghd.3_Intron|POLR2A_uc002ghe.2_5'Flank|POLR2A_uc002ghf.3_5'Flank	NM_001102614	NP_001096084	P0C7Q6	AMCL3_HUMAN	acyl-malonyl condensing enzyme 1-like 3	25						integral to membrane					0		Prostate(122;0.173)				CACCCAGCCTCCGCTGGCACC	0.667			NA											13	66					1.62849e-17	2.26641e-17	0.004007	1	0
TP53	7157	broad.mit.edu	37	17	7578448	7578448	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:7578448G>A	uc002gim.2	-	5	676	c.482C>T	c.(481-483)GCC>GTC	p.A161V	TP53_uc002gig.1_Missense_Mutation_p.A161V|TP53_uc002gih.2_Missense_Mutation_p.A161V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A29V|TP53_uc010cng.1_Missense_Mutation_p.A29V|TP53_uc002gii.1_Missense_Mutation_p.A29V|TP53_uc010cnh.1_Missense_Mutation_p.A161V|TP53_uc010cni.1_Missense_Mutation_p.A161V|TP53_uc002gij.2_Missense_Mutation_p.A161V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A68V|TP53_uc002gio.2_Missense_Mutation_p.A29V|TP53_uc010vug.1_Missense_Mutation_p.A122V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.A161D(8)|p.0?(7)|p.A161V(7)|p.A161A(5)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.A161fs*20(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.A159_Q167delAMAIYKQSQ(1)|p.S149fs*72(1)|p.V157_I162delVRAMAI(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.A161S(1)|p.A161P(1)|p.I162fs*8(1)|p.A161F(1)|p.A161G(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGTAGATGGCCATGGCGCG	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			35	35					0	0	0.00361	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Silent	SNP	C	C	A	rs55863639		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	34					4.78724e-31	7.3521e-31	0.00361	1	0
KCNAB3	9196	broad.mit.edu	37	17	7831100	7831100	+	Splice_Site	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:7831100C>G	uc002gjm.1	-	2	286	c.286_splice	c.e2+1	p.G96_splice	KCNAB3_uc010vul.1_Splice_Site	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related							cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)				TTCTGACTCACCTAGGCCAAG	0.522			NA											24	150					0	0	0.00632	0	0
MYH8	4626	broad.mit.edu	37	17	10298475	10298475	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:10298475T>C	uc002gmm.2	-	34	5032	c.4937A>G	c.(4936-4938)TAC>TGC	p.Y1646C	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1646	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGTGTTCCTGTAGTTCCTTAA	0.458			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				6	106					0	0	0.00308	0	0
PIGL	9487	broad.mit.edu	37	17	16220021	16220021	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:16220021C>T	uc002gpv.2	+	5	553	c.521C>T	c.(520-522)CCT>CTT	p.P174L	PIGL_uc010vwd.1_Missense_Mutation_p.P174L	NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	174	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		GGGAAGTTACCTAAAGGTAAG	0.493			NA											26	54					0	0	0.003271	0	0
EVPLL	645027	broad.mit.edu	37	17	18286156	18286157	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:18286156_18286157GG>CT	uc002gte.2	+	6	744_745	c.489_490GG>CT	c.(487-492)CCGGAG>CCCTAG	p.E164*		NM_001145127	NP_001138599	A8MZ36	EVPLL_HUMAN	envoplakin-like	164											0						GCCACCATCCGGAGCCAATACC	0.678			NA											6	32					0	0	0.004672	0	0
FAM83G	644815	broad.mit.edu	37	17	18882139	18882139	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:18882139C>A	uc002guw.2	-	5	1007	c.840G>T	c.(838-840)ACG>ACT	p.T280T	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	280										ovary(1)|central_nervous_system(1)	2						CATTCCGGTCCGTCCGCGCGG	0.637			NA											16	87					2.94398e-08	3.49468e-08	0.007413	1	0
MAP2K3	5606	broad.mit.edu	37	17	21201792	21201792	+	Splice_Site	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:21201792G>C	uc002gys.2	+	2	381	c.116_splice	c.e2+1	p.T39_splice	MAP2K3_uc002gyt.2_Splice_Site_p.T10_splice|MAP2K3_uc002gyu.2_Splice_Site_p.T10_splice	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3						activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CCAACCCCACGTGAGTCTGCC	0.577			NA											11	309					0	0	0.00245	0	0
Unknown	0	broad.mit.edu	37	17	21730858	21730858	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:21730858C>T	uc002gyy.3	+	2	285	c.160C>T	c.(160-162)CGC>TGC	p.R54C						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GGAAGATGGCCGCAGTCTTTC	0.517			NA											6	55					0	0	0.001984	0	0
NOS2	4843	broad.mit.edu	37	17	26125764	26125764	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:26125764G>A	uc002gzu.2	-	2	336	c.72C>T	c.(70-72)ATC>ATT	p.I24I	NOS2_uc010crh.1_Silent_p.I24I|NOS2_uc010wab.1_Silent_p.I24I	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	24					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CATTGTTGTTGATGTCTTTTT	0.507			NA											9	65					0	0	0.001368	0	0
SARM1	23098	broad.mit.edu	37	17	26699056	26699056	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:26699056G>T	uc010crl.1	+	1	70	c.3G>T	c.(1-3)ATG>ATT	p.M1I	SARM1_uc010wah.1_Intron|SARM1_uc010waj.1_Intron|VTN_uc002hbc.2_5'Flank	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	1					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CCGCGCCCATGGTCCTGACGC	0.716			NA											4	2					1.23904e-05	1.37686e-05	0.000602	1	0
NEK8	284086	broad.mit.edu	37	17	27061141	27061141	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:27061141T>C	uc002hcp.2	+	2	188	c.188T>C	c.(187-189)GTC>GCC	p.V63A		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	63	Protein kinase.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					CACCCCAATGTCATTGAGTAC	0.542	NSCLC(6;19 293 14866 25253 49845)		NA											71	75					0	0	0.00361	0	0
EVI2B	2124	broad.mit.edu	37	17	29632234	29632234	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:29632234G>T	uc002hgk.2	-	2	549	c.394C>A	c.(394-396)CGT>AGT	p.R132S	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.R147S	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	132	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GTAGAAGTACGGGCAGATGGT	0.443			NA											50	262					1.88225e-35	2.94906e-35	0.00361	1	0
RHBDL3	162494	broad.mit.edu	37	17	30648077	30648077	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:30648077C>A	uc002hhe.1	+	9	1058	c.1044C>A	c.(1042-1044)GCC>GCA	p.A348A	RHBDL3_uc010csw.1_Silent_p.A340A|RHBDL3_uc010csx.1_Missense_Mutation_p.R315S|RHBDL3_uc010csy.1_Silent_p.A250A|RHBDL3_uc002hhf.1_Silent_p.A250A	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	348	Helical; (Potential).				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GTGGCGTGGCCGTGGGCATCA	0.637			NA											47	50					1.4374e-25	2.15503e-25	0.00361	1	0
CCL11	6356	broad.mit.edu	37	17	32614165	32614165	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:32614165C>G	uc002hia.1	+	2	268	c.127C>G	c.(127-129)CTT>GTT	p.L43V		NM_002986	NP_002977	P51671	CCL11_HUMAN	small inducible cytokine A11 precursor	43					cell adhesion|cellular calcium ion homeostasis|immune response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|protein phosphorylation|response to radiation|response to virus|signal transduction	extracellular space	chemokine activity				0	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		GAAGATACCCCTTCAGCGACT	0.428			NA											18	76					0	0	0.00278	0	0
CCT6B	10693	broad.mit.edu	37	17	33259506	33259506	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:33259506A>T	uc002hig.2	-	11	1321	c.1227T>A	c.(1225-1227)CCT>CCA	p.P409P	CCT6B_uc010ctg.2_Silent_p.P372P|CCT6B_uc010wcc.1_Silent_p.P364P	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	409					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				CACCAGCTCCAGGAACCATAC	0.398			NA											31	142					0	0	0.004878	0	0
UNC45B	146862	broad.mit.edu	37	17	33504092	33504092	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:33504092C>A	uc002hja.2	+	16	2185	c.2088C>A	c.(2086-2088)CAC>CAA	p.H696Q	UNC45B_uc002hjb.2_Missense_Mutation_p.H694Q|UNC45B_uc002hjc.2_Missense_Mutation_p.H694Q|UNC45B_uc010cto.2_Missense_Mutation_p.H615Q	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	696					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				AGGCAGCCCACGCTCTAGCAA	0.567			NA											58	61					7.14007e-55	1.16199e-54	0.00361	1	0
LYZL6	57151	broad.mit.edu	37	17	34264792	34264792	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:34264792A>G	uc002hkj.1	-	2	418	c.268T>C	c.(268-270)TCG>CCG	p.S90P	LYZL6_uc002hkk.1_Missense_Mutation_p.S90P	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	90					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGTTTTCCGAGTAACTCTTA	0.483			NA											5	91					0	0	0.001168	0	0
GGNBP2	79893	broad.mit.edu	37	17	34935751	34935751	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:34935751G>A	uc002hnb.2	+	8	1171	c.922G>A	c.(922-924)GAA>AAA	p.E308K	GGNBP2_uc002hna.2_Missense_Mutation_p.E308K|GGNBP2_uc002hnc.1_Missense_Mutation_p.E137K	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	308					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TCATCTTTATGAAAGACTGCA	0.423			NA											28	145					0	0	0.009535	0	0
TBC1D3	729873	broad.mit.edu	37	17	36288223	36288223	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:36288223C>G	uc002hoo.2	+	6	466	c.309C>G	c.(307-309)CCC>CCG	p.P103P	TBC1D3_uc002hop.2_RNA|TBC1D3_uc010wdj.1_Silent_p.P23P|TBC1D3_uc010cvf.1_Silent_p.P103P|TBC1D3_uc002hoq.2_Silent_p.P103P|TBC1D3_uc010wdk.1_Silent_p.P164P|uc002hpl.2_5'Flank|uc002hor.2_5'Flank	NM_032258	NP_115634	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3F	103	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGAATGCCCATGAACATCC	0.567			NA											59	547					0	0	0.00361	0	0
CACNB1	782	broad.mit.edu	37	17	37340312	37340312	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:37340312A>T	uc002hrm.1	-	10	1023	c.870T>A	c.(868-870)ATT>ATA	p.I290I	CACNB1_uc002hrl.1_Silent_p.I62I|CACNB1_uc002hrn.2_Silent_p.I290I|CACNB1_uc002hro.2_Silent_p.I335I	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	290					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	TGGAGCGCTCAATGATGATGT	0.488	Esophageal Squamous(5;100 366 38393 41452 45827)		NA											19	65					0	0	0.00278	0	0
PSMD3	5709	broad.mit.edu	37	17	38140601	38140601	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:38140601G>A	uc002htn.1	+	2	439	c.275G>A	c.(274-276)AGA>AAA	p.R92K	PSMD3_uc010wen.1_Intron|PSMD3_uc010weo.1_Splice_Site	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	92					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					AAGGAGCCGAGATTCGTGCTG	0.502	Ovarian(186;531 2051 6385 19668 48409)		NA											9	60					0	0	0.008291	0	0
SMARCE1	6605	broad.mit.edu	37	17	38785088	38785088	+	Silent	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:38785088T>G	uc002hux.2	-	11	1309	c.1185A>C	c.(1183-1185)ACA>ACC	p.T395T	SMARCE1_uc010wff.1_3'UTR|SMARCE1_uc010wfg.1_3'UTR|SMARCE1_uc002huy.2_Silent_p.T360T|SMARCE1_uc010wfh.1_Silent_p.T325T|SMARCE1_uc010wfi.1_Silent_p.T377T	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	395	Glu-rich.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				GCTCCTCCACTGTTGCACTGT	0.453			NA											53	81					0	0	0.00361	0	0
KRT25	147183	broad.mit.edu	37	17	38907322	38907322	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:38907322G>T	uc002hve.2	-	5	902	c.841C>A	c.(841-843)CTG>ATG	p.L281M		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	281	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TGCTGCTGCAGGGAGGCGCTC	0.483			NA											11	62					1.3612e-06	1.55017e-06	0.003163	1	0
KRT36	8689	broad.mit.edu	37	17	39642635	39642635	+	Missense_Mutation	SNP	G	G	T	rs148487920		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:39642635G>T	uc002hwt.2	-	7	1397	c.1397C>A	c.(1396-1398)CCG>CAG	p.P466Q		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	466	Tail.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CTGTCACAGCGGGCGGGACTG	0.637			NA											7	48					8.12818e-05	8.86631e-05	0.001984	1	0
KRT36	8689	broad.mit.edu	37	17	39645719	39645719	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:39645719A>G	uc002hwt.2	-	1	398	c.398T>C	c.(397-399)ATC>ACC	p.I133T		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	133	Rod.|Linker 1.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				GATGTATGGGATCTGAAACTC	0.582			NA											101	102					0	0	0.00361	0	0
FMNL1	752	broad.mit.edu	37	17	43322352	43322352	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:43322352G>C	uc002iin.2	+	21	2805	c.2605G>C	c.(2605-2607)GAG>CAG	p.E869Q	FMNL1_uc002iiq.2_Missense_Mutation_p.E447Q|FMNL1_uc010dag.2_RNA|LOC100133991_uc010dah.2_5'Flank	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	869	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GCAGCTGTTGGAGATGAAGTC	0.607	GBM(164;1247 1997 8702 11086 51972)		NA											16	79					0	0	0.006122	0	0
TBX21	30009	broad.mit.edu	37	17	45822276	45822276	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:45822276T>C	uc002ilv.1	+	6	1363	c.1152T>C	c.(1150-1152)GCT>GCC	p.A384A		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	384					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						TTCCCCAGGCTTACTGGCTGG	0.617			NA											16	104					0	0	0.006122	0	0
HOXB9	3219	broad.mit.edu	37	17	46700309	46700309	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:46700309G>T	uc002inx.2	-	2	910	c.706C>A	c.(706-708)CGG>AGG	p.R236R		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	236	Homeobox.				canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTCATCCGCCGGTTCTGAAAC	0.463			NA											11	74					1.61879e-10	2.01649e-10	0.001368	1	0
CA10	56934	broad.mit.edu	37	17	50235144	50235144	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:50235144C>T	uc002itw.3	-	1	989	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CA10_uc002itv.3_5'UTR|CA10_uc002itx.3_Missense_Mutation_p.M1I|CA10_uc002ity.3_Missense_Mutation_p.M1I|CA10_uc002itz.2_Missense_Mutation_p.M1I	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	1					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			AGACTATTTCCATCCTCTGAT	0.517			NA											21	105					0	0	0.00278	0	0
KIF2B	84643	broad.mit.edu	37	17	51901177	51901177	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:51901177C>A	uc002iua.2	+	1	939	c.783C>A	c.(781-783)AAC>AAA	p.N261K	uc010wna.1_Intron	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	261	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ACCTGCAGAACCAGACCTTCT	0.542			NA											22	46					4.26978e-12	5.46727e-12	0.00333	1	0
TEX14	56155	broad.mit.edu	37	17	56679300	56679300	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:56679300C>T	uc010dcz.1	-	13	1681	c.1563G>A	c.(1561-1563)CAG>CAA	p.Q521Q	TEX14_uc002iwr.1_Silent_p.Q515Q|TEX14_uc002iws.1_Silent_p.Q515Q|TEX14_uc010dda.1_Silent_p.Q295Q	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	521						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTGAGTTCTCTGGGCTCCAG	0.468			NA											7	59					0	0	0.006214	0	0
LOC653653	653653	broad.mit.edu	37	17	58179857	58179857	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:58179857A>T	uc010wot.1	-	1	424	c.308T>A	c.(307-309)ATT>AAT	p.I103N		NM_003916	NP_003907			adaptor-related protein complex 1 sigma 2												0						TTTGTAAACAATCTTCAGATC	0.348			NA											22	110					0	0	0.00278	0	0
USP32	84669	broad.mit.edu	37	17	58303470	58303470	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:58303470C>T	uc002iyo.1	-	13	1648	c.1362G>A	c.(1360-1362)GTG>GTA	p.V454V	USP32_uc002iyn.1_Silent_p.V124V	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	454	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.V454L(1)		lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CTGTAGTATTCACGTAACTGA	0.428			NA											21	99					0	0	0.00333	0	0
ABCA9	10350	broad.mit.edu	37	17	67023491	67023491	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:67023491C>T	uc002jhu.2	-	14	2034	c.1891G>A	c.(1891-1893)GCC>ACC	p.A631T	ABCA9_uc010dez.2_Missense_Mutation_p.A631T	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	631	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CCTAAAATGGCAATCCCAAAA	0.313			NA											7	10					0	0	0.008291	0	0
ABCA6	23460	broad.mit.edu	37	17	67114099	67114099	+	Splice_Site	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:67114099T>A	uc002jhw.1	-	11	1612	c.1437_splice	c.e11-1	p.R479_splice	ABCA6_uc002jhx.1_5'UTR	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6						transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TTTCTGATTCTGAAATAACAA	0.338			NA											16	26					0	0	0.008871	0	0
CD300E	342510	broad.mit.edu	37	17	72613365	72613365	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:72613365G>C	uc002jlb.1	-	2	321	c.280C>G	c.(280-282)CTC>GTC	p.L94V		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	94	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCTTCATTGAGGTTCTGCATG	0.537			NA											52	87					0	0	0.00361	0	0
CD300LF	146722	broad.mit.edu	37	17	72694570	72694570	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:72694570A>T	uc002jlg.2	-	4	600	c.497T>A	c.(496-498)TTG>TAG	p.L166*	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Nonsense_Mutation_p.L169*|CD300LF_uc010dfw.2_Intron|CD300LF_uc002jlh.2_Silent_p.I181I|CD300LF_uc002jli.2_Intron|CD300LF_uc010wra.1_Nonsense_Mutation_p.L181*|CD300LF_uc002jlj.1_Nonsense_Mutation_p.L184*	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	166	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						AAGCAGCAGCAATATGGTGAA	0.582			NA											4	35					0	0	0.000602	0	0
USH1G	124590	broad.mit.edu	37	17	72919127	72919127	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:72919127C>A	uc002jme.1	-	1	225	c.42G>T	c.(40-42)CTG>CTT	p.L14L	USH1G_uc010wro.1_5'UTR|OTOP2_uc002jmf.1_5'Flank|OTOP2_uc010wrp.1_5'Flank	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	14					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					TGAGGAGCTCCAGGTAGCCAT	0.687			NA											5	2					2.7689e-08	3.30238e-08	0.001984	1	0
OTOP2	92736	broad.mit.edu	37	17	72926928	72926928	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:72926928G>A	uc010wrp.1	+	7	1287	c.1198G>A	c.(1198-1200)GCA>ACA	p.A400T		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	400						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					GGACCTGCTGGCAGGGCTCAA	0.622			NA											21	71					0	0	0.001882	0	0
GRB2	2885	broad.mit.edu	37	17	73317755	73317755	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:73317755T>C	uc002jnx.3	-	5	810	c.453A>G	c.(451-453)ATA>ATG	p.I151M	GRB2_uc002jny.3_Missense_Mutation_p.I110M	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	151	SH2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	GCACCTGTTCTATGTCCCGCA	0.478			NA											19	78					0	0	0.003954	0	0
QRICH2	84074	broad.mit.edu	37	17	74271963	74271963	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:74271963T>C	uc002jrd.1	-	18	5101	c.4921A>G	c.(4921-4923)AGC>GGC	p.S1641G	QRICH2_uc010wsz.1_Missense_Mutation_p.Q1333R|QRICH2_uc010dgw.1_Missense_Mutation_p.S485G	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1641							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCATTGCTGCTGAGGGATGGC	0.667			NA											24	50					0	0	0.00632	0	0
MGAT5B	146664	broad.mit.edu	37	17	74922712	74922712	+	Silent	SNP	G	G	A	rs144217759		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:74922712G>A	uc002jti.2	+	9	1327	c.1224G>A	c.(1222-1224)ACG>ACA	p.T408T	MGAT5B_uc002jth.2_Silent_p.T397T	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	397	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CCTTCGGGACGGAACCTGCGT	0.622			NA											16	49					0	0	0.004007	0	0
HGS	9146	broad.mit.edu	37	17	79662894	79662894	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:79662894G>A	uc002kbg.2	+	15	1335	c.1258G>A	c.(1258-1260)GTG>ATG	p.V420M		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	420	Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CACCACCTTCGTGAACCGCAT	0.602			NA											16	54					0	0	0.004007	0	0
CETN1	1068	broad.mit.edu	37	18	580575	580575	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:580575C>A	uc002kko.1	+	1	209	c.167C>A	c.(166-168)GCC>GAC	p.A56D		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	56	EF-hand 1.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTGAAGGTGGCCATGAGAGCG	0.552			NA											54	50					1.85204e-48	2.9804e-48	0.00361	1	0
CLUL1	27098	broad.mit.edu	37	18	633426	633426	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:633426C>T	uc002kkp.2	+	6	1130	c.985C>T	c.(985-987)CTA>TTA	p.L329L	CLUL1_uc010wys.1_Silent_p.L381L|CLUL1_uc002kkq.2_Silent_p.L329L	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	329					cell death	extracellular region				ovary(2)	2						TCAGGCTCACCTATCTGAAGG	0.299			NA											13	54					0	0	0.00499	0	0
NDC80	10403	broad.mit.edu	37	18	2577750	2577750	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:2577750G>A	uc002kli.2	+	4	367	c.185G>A	c.(184-186)AGT>AAT	p.S62N		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	62	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						TCCAGAACTAGTGGACATGGA	0.353			NA											21	118					0	0	0.003954	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891450	2891450	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:2891450C>T	uc002kln.2	+	4	1484	c.1325C>T	c.(1324-1326)CCA>CTA	p.P442L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	442					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		GTTCCAGAGCCAGATGTGGAT	0.433			NA											44	109					0	0	0.003214	0	0
EPB41L3	23136	broad.mit.edu	37	18	5394744	5394744	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:5394744A>T	uc002kmt.1	-	22	3288	c.3202T>A	c.(3202-3204)TCA>ACA	p.S1068T	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Missense_Mutation_p.S846T|EPB41L3_uc010dkq.1_Missense_Mutation_p.S737T|EPB41L3_uc002kms.1_Missense_Mutation_p.S303T|EPB41L3_uc010wze.1_Missense_Mutation_p.S373T|EPB41L3_uc010wzf.1_Missense_Mutation_p.S365T|EPB41L3_uc010wzg.1_Missense_Mutation_p.S340T|EPB41L3_uc010dkr.2_Missense_Mutation_p.S460T	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1068	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTGGTCACTGACATGTCAGGG	0.507			NA											19	274					0	0	0.004656	0	0
LAMA1	284217	broad.mit.edu	37	18	7011460	7011460	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:7011460G>T	uc002knm.2	-	25	3620	c.3526C>A	c.(3526-3528)CAG>AAG	p.Q1176K	LAMA1_uc010wzj.1_Missense_Mutation_p.Q652K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1176	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAAGAGGCTGATCGGAGCCC	0.532			NA											8	19					0.000442599	0.000475594	0.006214	1	0
ANKRD12	23253	broad.mit.edu	37	18	9255108	9255108	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:9255108G>C	uc002knv.2	+	9	2100	c.1843G>C	c.(1843-1845)GAA>CAA	p.E615Q	ANKRD12_uc002knw.2_Missense_Mutation_p.E592Q|ANKRD12_uc002knx.2_Missense_Mutation_p.E592Q|ANKRD12_uc010dkx.1_Missense_Mutation_p.E322Q	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	615						nucleus				ovary(2)|central_nervous_system(1)	3						TTTCCACTTAGAATTTGGTGA	0.249			NA											9	173					0	0	0.006214	0	0
C18orf1	753	broad.mit.edu	37	18	13621256	13621256	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:13621256G>T	uc002ksa.2	+	5	990	c.322G>T	c.(322-324)GAC>TAC	p.D108Y	C18orf1_uc002ksb.2_Missense_Mutation_p.D108Y|C18orf1_uc002kse.2_Missense_Mutation_p.D71Y|C18orf1_uc002ksf.2_Missense_Mutation_p.D71Y|C18orf1_uc002ksg.1_Missense_Mutation_p.D31Y|C18orf1_uc002ksh.1_Missense_Mutation_p.D50Y|C18orf1_uc002ksi.1_Missense_Mutation_p.D50Y	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	108	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GAGGCGGGAGGACGGGCTGCC	0.647			NA											28	117					2.46105e-21	3.57295e-21	0.002096	1	0
POTEC	388468	broad.mit.edu	37	18	14513693	14513693	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:14513693T>G	uc010dln.2	-	10	1955	c.1501A>C	c.(1501-1503)ATA>CTA	p.I501L	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	501	Potential.									skin(3)	3						GCCACTTCTATCTGCTTTTGT	0.299			NA											16	133					0	0	0.008871	0	0
LAMA3	3909	broad.mit.edu	37	18	21343483	21343483	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:21343483G>C	uc002kuq.2	+	8	1264	c.1178G>C	c.(1177-1179)TGT>TCT	p.C393S	LAMA3_uc010dlv.1_Missense_Mutation_p.C393S|LAMA3_uc002kur.2_Missense_Mutation_p.C393S	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	393	Domain V.|Laminin EGF-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCATTAACTGTCAGGTGAGG	0.488			NA											21	155					0	0	0.004656	0	0
MEP1B	4225	broad.mit.edu	37	18	29795168	29795168	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:29795168T>A	uc002kxj.3	+	12	1750	c.1703T>A	c.(1702-1704)CTG>CAG	p.L568Q		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	568	Extracellular (Potential).|MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						CACGAAAGGCTGAAAAGCAGA	0.368			NA											9	20					0	0	0.001855	0	0
DTNA	1837	broad.mit.edu	37	18	32405235	32405235	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:32405235A>G	uc010dmn.1	+	9	1007	c.1006A>G	c.(1006-1008)ACT>GCT	p.T336A	DTNA_uc002kxu.2_Missense_Mutation_p.T336A|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.T336A|DTNA_uc002kxw.2_Missense_Mutation_p.T336A|DTNA_uc002kxx.2_Intron|DTNA_uc010dmj.2_Intron|DTNA_uc002kxz.2_Intron|DTNA_uc002kxy.2_Intron|DTNA_uc010dmk.1_Intron|DTNA_uc010dml.2_Intron|DTNA_uc002kyb.3_Intron|DTNA_uc010dmm.2_Missense_Mutation_p.T336A|DTNA_uc010xby.1_Intron|DTNA_uc010dmo.2_Intron|DTNA_uc002kyd.3_Intron|DTNA_uc010xbz.1_Intron|DTNA_uc010xca.1_Intron|DTNA_uc002kye.2_Intron	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	336					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						CAAAAGTGATACTTGGTAAGT	0.348			NA											20	159					0	0	0.005443	0	0
SETBP1	26040	broad.mit.edu	37	18	42530331	42530331	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:42530331G>C	uc010dni.2	+	4	1322	c.1026G>C	c.(1024-1026)GTG>GTC	p.V342V		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	342						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAAAAGATGTGATAAGTCAGA	0.483			NA							Schinzel-Giedion_syndrome				18	71					0	0	0.007413	0	0
SIGLEC15	284266	broad.mit.edu	37	18	43420203	43420203	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:43420203C>A	uc002lbl.1	+	5	1051	c.902C>A	c.(901-903)CCA>CAA	p.P301Q	SIGLEC15_uc010xcp.1_RNA	NM_213602	NP_998767	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15 precursor	301	Cytoplasmic (Potential).					integral to membrane					0						GACACCCCACCACGGTAAGTG	0.637			NA											10	128					5.50884e-06	6.17602e-06	0.001368	1	0
ALPK2	115701	broad.mit.edu	37	18	56203946	56203946	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:56203946G>A	uc002lhj.3	-	5	3687	c.3473C>T	c.(3472-3474)CCT>CTT	p.P1158L	ALPK2_uc002lhk.1_Missense_Mutation_p.P489L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1158							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AGATGTCGTAGGCAAACTTTG	0.552			NA											17	71					0	0	0.002299	0	0
ALPK2	115701	broad.mit.edu	37	18	56247148	56247148	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:56247148T>C	uc002lhj.3	-	4	1074	c.860A>G	c.(859-861)GAC>GGC	p.D287G		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	287							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CACGGCACTGTCACCTGGGTA	0.493			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	43					0	0	0.001368	0	0
SERPINB7	8710	broad.mit.edu	37	18	61449703	61449703	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:61449703C>A	uc002ljl.2	+	2	193	c.97C>A	c.(97-99)CTG>ATG	p.L33M	SERPINB7_uc002ljm.2_Missense_Mutation_p.L33M|SERPINB7_uc010xet.1_Missense_Mutation_p.L33M|SERPINB7_uc010dqg.2_Missense_Mutation_p.L33M	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	33					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				CTTTTCCTCTCTGAGCCTCTT	0.493			NA											29	46					9.45814e-24	1.39931e-23	0.004878	1	0
CDH7	1005	broad.mit.edu	37	18	63481777	63481777	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:63481777A>G	uc002ljz.2	+	4	887	c.562A>G	c.(562-564)AGT>GGT	p.S188G	CDH7_uc002lka.2_Missense_Mutation_p.S188G|CDH7_uc002lkb.2_Missense_Mutation_p.S188G	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	188	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATATGGCAACAGTGCCAGAGT	0.433			NA											43	78					0	0	0.00361	0	0
CDH7	1005	broad.mit.edu	37	18	63548025	63548025	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:63548025C>G	uc002ljz.2	+	12	2578	c.2253C>G	c.(2251-2253)ATC>ATG	p.I751M	CDH7_uc002lkb.2_Missense_Mutation_p.I751M	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	751	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TAGATTCCATCAGCTCAAACT	0.473			NA											9	97					0	0	0.008291	0	0
CD226	10666	broad.mit.edu	37	18	67563206	67563206	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:67563206T>A	uc010dqo.2	-	3	905	c.458A>T	c.(457-459)CAG>CTG	p.Q153L	CD226_uc002lkm.3_Missense_Mutation_p.Q153L	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	153	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				CATCTGAGGCTGACAAGTGAG	0.473	NSCLC(184;838 2130 8673 21498 50749)		NA											29	29					0	0	0.003755	0	0
FBXO15	201456	broad.mit.edu	37	18	71796717	71796717	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:71796717T>C	uc002lle.2	-	5	816	c.480A>G	c.(478-480)CTA>CTG	p.L160L	FBXO15_uc002llf.2_Silent_p.L236L	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	160										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		ACAATGATGCTAGGCATGGCC	0.378			NA											11	33					0	0	0.001368	0	0
TSHZ1	10194	broad.mit.edu	37	18	72999519	72999519	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:72999519C>T	uc002lly.2	+	2	2585	c.2022C>T	c.(2020-2022)CTC>CTT	p.L674L		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	719						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CAGAGCCTCTCAAAGCAAAGG	0.572			NA											6	31					0	0	0.00308	0	0
CTDP1	9150	broad.mit.edu	37	18	77455237	77455237	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:77455237G>C	uc002lnh.1	+	2	474	c.327G>C	c.(325-327)GTG>GTC	p.V109V	CTDP1_uc002lni.1_Silent_p.V109V|CTDP1_uc010drd.1_Silent_p.V109V	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	109					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGGTTCTGGTGAGGTTGGAAG	0.378			NA											12	57					0	0	0.003163	0	0
CTDP1	9150	broad.mit.edu	37	18	77477965	77477965	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:77477965C>T	uc002lnh.1	+	10	2513	c.2366C>T	c.(2365-2367)CCC>CTC	p.P789L	CTDP1_uc002lni.1_Missense_Mutation_p.P789L|CTDP1_uc010drd.1_Missense_Mutation_p.P789L	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	789					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GCCCGGGGGCCCCCAGCACCC	0.667			NA											4	61					0	0	0.001168	0	0
PRSSL1	400668	broad.mit.edu	37	19	694890	694890	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:694890C>A	uc002lpl.1	-	2	191	c.160G>T	c.(160-162)GGG>TGG	p.G54W	PRSSL1_uc010xfs.1_Missense_Mutation_p.G53W	NM_214710	NP_999875	Q6UWY2	PRS57_HUMAN	protease, serine-like 1 precursor	54	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTTGGCCCCCGAAGCGCACG	0.697			NA											8	1					2.17888e-05	2.40535e-05	0.006214	1	0
ABCA7	10347	broad.mit.edu	37	19	1043466	1043466	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:1043466G>C	uc002lqw.3	+	9	1155	c.924G>C	c.(922-924)ATG>ATC	p.M308I	ABCA7_uc010dsb.1_Missense_Mutation_p.M170I	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	308	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGCTCATGGCCCAGGTGG	0.652			NA											33	95					0	0	0.006999	0	0
DAZAP1	26528	broad.mit.edu	37	19	1428883	1428883	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:1428883G>T	uc002lsn.2	+	8	778	c.589G>T	c.(589-591)GCG>TCG	p.A197S	DAZAP1_uc002lsm.2_Missense_Mutation_p.A197S|DAZAP1_uc002lso.2_Missense_Mutation_p.A196S|DAZAP1_uc002lsl.1_Missense_Mutation_p.A197S	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	197					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGAGCCAAGCGCCGGGACA	0.657			NA											12	50					6.40141e-05	6.99029e-05	0.000978	1	0
CREB3L3	84699	broad.mit.edu	37	19	4170148	4170148	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:4170148G>T	uc002lzl.2	+	7	949	c.833G>T	c.(832-834)TGC>TTC	p.C278F	CREB3L3_uc002lzm.2_Missense_Mutation_p.C268F|CREB3L3_uc010xib.1_Missense_Mutation_p.C267F|CREB3L3_uc010xic.1_Missense_Mutation_p.L233F	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	278	Cytoplasmic (Potential).|Leucine-zipper.				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTCAGCTTGCACTGCTCAG	0.468			NA											23	78					1.74197e-06	1.97711e-06	0.00632	1	0
PTPRS	5802	broad.mit.edu	37	19	5218454	5218454	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:5218454C>G	uc002mbv.2	-	25	4259	c.4025G>C	c.(4024-4026)AGA>ACA	p.R1342T	PTPRS_uc002mbu.1_Missense_Mutation_p.R911T|PTPRS_uc010xin.1_Missense_Mutation_p.R911T|PTPRS_uc002mbw.2_Missense_Mutation_p.R1320T|PTPRS_uc002mbx.2_Missense_Mutation_p.R915T|PTPRS_uc002mby.2_Missense_Mutation_p.R911T	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1342	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTTAATGCGTCTCATTTCCAC	0.552			NA											13	246					0	0	0.00499	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456536	5456536	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:5456536G>A	uc002mca.3	+	1	1111	c.1034G>A	c.(1033-1035)CGG>CAG	p.R345Q		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	345	RING-type; atypical.|Cytoplasmic (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CAAGCCCCCCGGCGCTCCTGC	0.622			NA											18	103					0	0	0.00278	0	0
TUBB4	10382	broad.mit.edu	37	19	6495474	6495474	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:6495474G>T	uc002mfg.1	-	4	1143	c.1036C>A	c.(1036-1038)CCC>ACC	p.P346T	TUBB4_uc002mff.1_Missense_Mutation_p.P274T|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	346					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		ACGTTGTTGGGGATCCACTCC	0.632			NA											89	118					1.44786e-46	2.32256e-46	0.00361	1	0
CD70	970	broad.mit.edu	37	19	6590933	6590933	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:6590933G>T	uc002mfi.2	-	1	231	c.81C>A	c.(79-81)GTC>GTA	p.V27V	CD70_uc010xjf.1_Silent_p.V27V	NM_001252	NP_001243	P32970	CD70_HUMAN	tumor necrosis factor ligand superfamily, member	27	Helical; Signal-anchor for type II membrane protein; (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding				0						CCAAGCCCGCGACCAATGGGA	0.662	Pancreas(183;2617 2876 10173 34193)		NA											12	70					2.32078e-09	2.82811e-09	0.003163	1	0
EMR1	2015	broad.mit.edu	37	19	6890521	6890521	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:6890521C>A	uc002mfw.2	+	2	99	c.61C>A	c.(61-63)CAC>AAC	p.H21N	EMR1_uc010dvc.2_Missense_Mutation_p.H21N|EMR1_uc010dvb.2_Missense_Mutation_p.H21N|EMR1_uc010xji.1_Missense_Mutation_p.H21N|EMR1_uc010xjj.1_Missense_Mutation_p.H21N	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	21	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CTGGGAAGGGCACATAAGACC	0.428			NA											5	25					2.7689e-08	3.30238e-08	0.001984	1	0
ZNF358	140467	broad.mit.edu	37	19	7584121	7584121	+	Translation_Start_Site	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:7584121C>T	uc002mgn.2	+	2	163	c.-7C>T	c.(-9--5)CACGC>CATGC			NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358						embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						GGCACATCCACGCCTGAAATG	0.602			NA											12	73					0	0	0.004007	0	0
ZNF358	140467	broad.mit.edu	37	19	7585782	7585782	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:7585782G>T	uc002mgn.2	+	2	1824	c.1654G>T	c.(1654-1656)GAG>TAG	p.E552*	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	552					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CCCTACCGGCGAGAGTCCAGA	0.652			NA											18	79					2.94398e-08	3.49468e-08	0.007413	1	0
CLEC4G	339390	broad.mit.edu	37	19	7794745	7794745	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:7794745C>G	uc002mhp.3	-	8	774	c.705G>C	c.(703-705)CAG>CAC	p.Q235H		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	235	Extracellular (Potential).|C-type lectin.					integral to membrane	protein binding|sugar binding				0						ACTGGTAGCCCTGAACCTTGC	0.612	Esophageal Squamous(146;540 1807 3349 19438 30853)		NA											10	78					0	0	0.00245	0	0
MUC16	94025	broad.mit.edu	37	19	9056231	9056232	+	Missense_Mutation	DNP	AA	AA	CT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:9056231_9056232AA>CT	uc002mkp.2	-	3	31418_31419	c.31214_31215TT>AG	c.(31213-31215)GTT>GAG	p.V10405E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10407	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCCCAGCTCAACGCTCTCTGT	0.485			NA											27	63					0	0	0.004672	0	0
SMARCA4	6597	broad.mit.edu	37	19	11136108	11136108	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:11136108G>T	uc002mqf.3	+	22	3376	c.3092G>T	c.(3091-3093)GGC>GTC	p.G1031V	SMARCA4_uc010dxp.2_Missense_Mutation_p.G1031V|SMARCA4_uc010dxo.2_Missense_Mutation_p.G1031V|SMARCA4_uc002mqg.1_Missense_Mutation_p.G1031V|SMARCA4_uc010dxq.2_Missense_Mutation_p.G1031V|SMARCA4_uc010dxr.2_Missense_Mutation_p.G1031V|SMARCA4_uc002mqj.3_Missense_Mutation_p.G1031V|SMARCA4_uc010dxs.2_Missense_Mutation_p.G1031V|SMARCA4_uc010dxt.1_Missense_Mutation_p.G251V|SMARCA4_uc002mqh.3_Missense_Mutation_p.G154V|SMARCA4_uc002mqi.1_Missense_Mutation_p.G234V	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1031					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGCAAAGGCGGCACCAAGACC	0.632			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				9	67					1.76689e-08	2.11232e-08	0.006214	1	0
ZNF441	126068	broad.mit.edu	37	19	11892146	11892146	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:11892146C>T	uc010dyj.2	+	4	1701	c.1507C>T	c.(1507-1509)CAT>TAT	p.H503Y	ZNF441_uc002msn.3_Missense_Mutation_p.H459Y	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	503	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGATGGACCTCATAAATGTAA	0.403			NA											29	48					0	0	0.007835	0	0
ZNF440	126070	broad.mit.edu	37	19	11943217	11943217	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:11943217C>G	uc002msp.1	+	4	1382	c.1226C>G	c.(1225-1227)TCA>TGA	p.S409*		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	409	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGATCTGCCTCACACCTTCGA	0.458			NA											19	75					0	0	0.00333	0	0
FBXW9	84261	broad.mit.edu	37	19	12805682	12805683	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:12805682_12805683CC>TA	uc010dyx.2	-	2	449_450	c.449_450GG>TA	c.(448-450)GGG>GTA	p.G150V	FBXW9_uc010xmp.1_Intron|FBXW9_uc002mum.1_Missense_Mutation_p.G160V|FBXW9_uc002mun.1_Intron	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	160							protein binding			ovary(1)	1						CGACCCAGCGCCCATCCTCTGC	0.644			NA											4	23					0	0	0.004672	0	0
PIK3R2	5296	broad.mit.edu	37	19	18273784	18273784	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18273784G>A	uc002nia.1	+	10	1629	c.1117G>A	c.(1117-1119)GGG>AGG	p.G373R	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	373	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						CAGGAAAGGCGGGAACAATAA	0.512			NA											11	94					0	0	0.00245	0	0
MPV17L2	84769	broad.mit.edu	37	19	18305825	18305825	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18305825C>G	uc002nid.2	+	4	545	c.493C>G	c.(493-495)CAA>GAA	p.Q165E	MPV17L2_uc010ebj.2_Missense_Mutation_p.P75R	NM_032683	NP_116072	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	165						integral to membrane					0						CGTGCCCCCCCAATTTCGAGT	0.478			NA											6	245					0	0	0.001984	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368153	18368153	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18368153A>C	uc002nin.2	-	4	3596	c.3380T>G	c.(3379-3381)TTT>TGT	p.F1127C	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.F1314C|KIAA1683_uc010xqe.1_Missense_Mutation_p.F1081C|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	1127	IQ 5.					mitochondrion				ovary(2)	2						GCGGATCTTAAAGCCCCTCCA	0.622			NA											12	96					0	0	0.004007	0	0
FKBP8	23770	broad.mit.edu	37	19	18649221	18649221	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18649221C>A	uc002njk.1	-	5	687	c.574G>T	c.(574-576)GCG>TCG	p.A192S	FKBP8_uc002nji.1_Missense_Mutation_p.A30S|FKBP8_uc010xqi.1_Missense_Mutation_p.A221S|FKBP8_uc002njj.1_Missense_Mutation_p.A193S|FKBP8_uc002njl.1_Missense_Mutation_p.A193S|FKBP8_uc002njm.1_Missense_Mutation_p.A192S|FKBP8_uc010ebr.1_Missense_Mutation_p.A31S|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	192	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						CACAGGGCCGCGTGCGGGGGG	0.682			NA											10	46					4.68919e-08	5.51444e-08	0.008291	1	0
CRLF1	9244	broad.mit.edu	37	19	18710436	18710436	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18710436G>T	uc010ebt.1	-	2	530	c.336C>A	c.(334-336)GAC>GAA	p.D112E		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	112	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						ACACGAGGTTGTCCCCCGACC	0.672			NA											11	58					9.70103e-10	1.1908e-09	0.008291	1	0
CRLF1	9244	broad.mit.edu	37	19	18710443	18710443	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18710443G>T	uc010ebt.1	-	2	523	c.329C>A	c.(328-330)TCG>TAG	p.S110*		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	110	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GTTGTCCCCCGACCGCTGCCT	0.672			NA											11	49					1.08611e-07	1.26254e-07	0.000978	1	0
TMEM59L	25789	broad.mit.edu	37	19	18727850	18727850	+	Missense_Mutation	SNP	G	G	A	rs61731609	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:18727850G>A	uc002njy.3	+	5	689	c.602G>A	c.(601-603)CGT>CAT	p.R201H	TMEM59L_uc010ebu.1_Missense_Mutation_p.R201H	NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	201						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CAGGGGGGCCGTCTGCAGCGC	0.642			NA											20	172					0	0	0.001882	0	0
NCAN	1463	broad.mit.edu	37	19	19349079	19349079	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:19349079C>T	uc002nlz.2	+	11	3367	c.3268C>T	c.(3268-3270)CGC>TGC	p.R1090C	NCAN_uc010ecc.1_Missense_Mutation_p.R654C|NCAN_uc002nma.2_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1090	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGGCTGTGACCGCGGCTGGCA	0.657			NA											64	90					0	0	0.00361	0	0
ZNF708	7562	broad.mit.edu	37	19	21476519	21476519	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:21476519T>C	uc002npq.1	-	4	1447	c.1249A>G	c.(1249-1251)AAG>GAG	p.K417E	ZNF708_uc002npr.1_Missense_Mutation_p.K353E|ZNF708_uc010ecs.1_Missense_Mutation_p.K353E	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						TAGGGTTTCTTTCCAGTATGA	0.343			NA											4	55					0	0	0.009096	0	0
ZNF208	7757	broad.mit.edu	37	19	22156743	22156743	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:22156743C>A	uc002nqp.2	-	4	1242	c.1093G>T	c.(1093-1095)GGA>TGA	p.G365*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGTTTCTCTCCAGTATGAATT	0.388			NA											13	63					1.49906e-05	1.66214e-05	0.00245	1	0
ZNF257	113835	broad.mit.edu	37	19	22271347	22271347	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:22271347C>A	uc010ecx.2	+	4	964	c.795C>A	c.(793-795)GCC>GCA	p.A265A	ZNF257_uc010ecy.2_Silent_p.A233A	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	265	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTGGCAAAGCCTTTAACCGGT	0.388			NA											25	16					3.69857e-22	5.42421e-22	0.008361	1	0
ZNF91	7644	broad.mit.edu	37	19	23542980	23542980	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:23542980C>T	uc002nre.2	-	4	2914	c.2801G>A	c.(2800-2802)GGA>GAA	p.G934E	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.G902E	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	934						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGGTTTCTCTCCAGTGTGCAT	0.398			NA											12	115					0	0	0.00499	0	0
ZNF536	9745	broad.mit.edu	37	19	30935569	30935569	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:30935569A>G	uc002nsu.1	+	2	1238	c.1100A>G	c.(1099-1101)CAC>CGC	p.H367R	ZNF536_uc010edd.1_Missense_Mutation_p.H367R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	367	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ATGCGCAAGCACAAAGACTCC	0.612			NA											35	146					0	0	0.00623	0	0
CD22	933	broad.mit.edu	37	19	35823583	35823583	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:35823583C>T	uc010edt.2	+	3	245	c.168C>T	c.(166-168)TTC>TTT	p.F56F	CD22_uc010xst.1_5'UTR|CD22_uc010edu.2_Silent_p.F56F|CD22_uc010edv.2_Silent_p.F56F|CD22_uc002nzb.3_Silent_p.F56F	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	56	Extracellular (Potential).|Ig-like V-type.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGGAAAGCTTCATCCTGTTCC	0.512	Ovarian(42;1009 1133 23674 26041)		NA											16	125					0	0	0.00278	0	0
MLL4	9757	broad.mit.edu	37	19	36220984	36220984	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:36220984G>C	uc010eei.2	+	24	5034	c.5034G>C	c.(5032-5034)AAG>AAC	p.K1678N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1678					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGATGACAAGAAAGTCTTCT	0.572			NA											4	17					0	0	0.000602	0	0
KCNK6	9424	broad.mit.edu	37	19	38817411	38817411	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:38817411G>T	uc002oic.2	+	2	611	c.501G>T	c.(499-501)CGG>CGT	p.R167R	KCNK6_uc002oid.2_Silent_p.R33R	NM_004823	NP_004814	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	167	Cytoplasmic (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)	1	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	ACCCCCGGCGGGCGGCCTGCT	0.672			NA											19	68					2.94398e-08	3.49468e-08	0.007413	1	0
FBXO27	126433	broad.mit.edu	37	19	39517606	39517606	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:39517606G>A	uc002okh.2	-	5	694	c.612C>T	c.(610-612)CTC>CTT	p.L204L		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	204	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GTTGGACGAGGAGTCTGTACA	0.562			NA											113	80					0	0	0.00361	0	0
LRFN1	57622	broad.mit.edu	37	19	39798904	39798904	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:39798904T>C	uc002okw.2	-	2	1685	c.1685A>G	c.(1684-1686)TAT>TGT	p.Y562C		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	562	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCCGTCGCCATACACCTTATA	0.657			NA											4	34					0	0	0.001168	0	0
FCGBP	8857	broad.mit.edu	37	19	40430340	40430340	+	Missense_Mutation	SNP	C	C	A	rs148563964		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:40430340C>A	uc002omp.3	-	3	1611	c.1603G>T	c.(1603-1605)GCC>TCC	p.A535S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	535	VWFD 1.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCTGTAGGCGCGCACAGTG	0.667			NA											8	49					2.80697e-09	3.38784e-09	0.000978	1	0
ZNF574	64763	broad.mit.edu	37	19	42583941	42583941	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:42583941C>T	uc002osm.3	+	2	1352	c.1183C>T	c.(1183-1185)CCA>TCA	p.P395S	ZNF574_uc002osk.3_Missense_Mutation_p.P485S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	395	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCATTCATGTCCATGTGGGAA	0.592			NA											22	75					0	0	0.00333	0	0
POU2F2	5452	broad.mit.edu	37	19	42599776	42599776	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:42599776C>A	uc002osp.2	-	10	942	c.875G>T	c.(874-876)GGC>GTC	p.G292V	POU2F2_uc002osn.2_Missense_Mutation_p.G276V|POU2F2_uc002oso.2_Missense_Mutation_p.G65V|POU2F2_uc002osq.2_Missense_Mutation_p.G276V|POU2F2_uc002osr.1_Missense_Mutation_p.G292V	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	292					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.V292V(1)		ovary(1)|skin(1)	2		Prostate(69;0.059)				GCCGGGCAGGCCGTCGAAACC	0.627			NA											28	19					4.31865e-32	6.65269e-32	0.004878	1	0
POU2F2	5452	broad.mit.edu	37	19	42600287	42600287	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:42600287C>A	uc002osp.2	-	8	677	c.610G>T	c.(610-612)GAG>TAG	p.E204*	POU2F2_uc002osn.2_Nonsense_Mutation_p.E188*|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Nonsense_Mutation_p.E188*|POU2F2_uc002osr.1_Nonsense_Mutation_p.E204*	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	204	POU-specific.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GCGAATTGCTCCAGCTCCTCC	0.692			NA											20	29					8.24728e-16	1.12301e-15	0.004656	1	0
CIC	23152	broad.mit.edu	37	19	42791820	42791820	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:42791820G>T	uc002otf.1	+	5	746	c.706G>T	c.(706-708)GAG>TAG	p.E236*		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	236	HMG box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GATCCTGGGCGAGTGGTGGTA	0.607			NA	T	DUX4	soft tissue sarcoma								52	40					7.41606e-26	1.11351e-25	0.00361	1	0
PSG8	440533	broad.mit.edu	37	19	43257524	43257524	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:43257524C>A	uc002ouh.2	-	6	1346	c.1248G>T	c.(1246-1248)TGG>TGT	p.W416C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.W255C|PSG8_uc010ein.2_Missense_Mutation_p.W294C|PSG8_uc002ouj.3_Missense_Mutation_p.W198C|PSG8_uc002ouk.3_Missense_Mutation_p.W255C|PSG8_uc002oul.3_Missense_Mutation_p.W416C|PSG8_uc002oum.3_Missense_Mutation_p.W323C|PSG1_uc002oun.2_RNA	NM_001130167	NP_001123639	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	416						extracellular region					0		Prostate(69;0.00899)				agggtaatgtccagtctacag	0			NA											14	68					0.000422831	0.000454837	0.004007	1	0
PSG4	5672	broad.mit.edu	37	19	43698701	43698701	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:43698701C>T	uc002ovy.2	-	5	1136	c.1034G>A	c.(1033-1035)CGT>CAT	p.R345H	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_Intron|PSG4_uc002owb.2_Missense_Mutation_p.R252H|PSG4_uc002ovz.2_Missense_Mutation_p.R252H	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	345	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				TTCTCCTGAACGGTAATAGGT	0.478			NA											32	223					0	0	0.002445	0	0
PSG9	5678	broad.mit.edu	37	19	43773566	43773566	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:43773566G>T	uc002owd.3	-	1	117	c.18C>A	c.(16-18)GCC>GCA	p.A6A	PSG9_uc002owe.3_Silent_p.A6A|PSG9_uc010xwm.1_Silent_p.A6A|PSG9_uc002owf.3_Silent_p.A6A|PSG9_uc002owg.2_Silent_p.A6A|PSG9_uc002owh.2_Silent_p.A6A	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	6					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGCAGGAAGGGGCTGGGAGGG	0.617			NA											25	171					2.95478e-19	4.19321e-19	0.00874	1	0
PHLDB3	653583	broad.mit.edu	37	19	44001348	44001348	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:44001348C>A	uc002own.3	-	6	1006	c.747G>T	c.(745-747)GAG>GAT	p.E249D	PHLDB3_uc010eit.2_5'Flank|PHLDB3_uc002owo.2_Missense_Mutation_p.E249D	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	249	Potential.										0		Prostate(69;0.0153)				CCCGATCCTCCTCCTCCTGCC	0.592			NA											18	84					1.37657e-19	1.9618e-19	0.001882	1	0
GEMIN7	79760	broad.mit.edu	37	19	45593559	45593559	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:45593559C>T	uc002pap.1	+	3	338	c.187C>T	c.(187-189)CGG>TGG	p.R63W	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.R63W|GEMIN7_uc002par.1_Missense_Mutation_p.R63W	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	63					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		AGCCGCCCTTCGGGAGCGTTA	0.632			NA											4	39					0	0	0.000602	0	0
KLC3	147700	broad.mit.edu	37	19	45851263	45851263	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:45851263G>A	uc002pbf.1	+	5	739	c.624G>A	c.(622-624)CGG>CGA	p.R208R	KLC3_uc010ejy.1_Silent_p.R207R|KLC3_uc002pbg.1_Silent_p.R222R	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	208	TPR 1.					cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGCCTTCGGACCCTGCATA	0.677			NA											5	23					0	0	0.001984	0	0
SPACA4	171169	broad.mit.edu	37	19	49110431	49110431	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:49110431C>A	uc002pjo.2	+	1	432	c.196C>A	c.(196-198)CTG>ATG	p.L66M	FAM83E_uc002pjn.2_Intron	NM_133498	NP_598005	Q8TDM5	SACA4_HUMAN	sperm acrosomal membrane protein 14 precursor	66	UPAR/Ly6 1.				cell adhesion	acrosomal vesicle|anchored to membrane|plasma membrane				central_nervous_system(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		CAAAGGCTGCCTGCGAGCCAC	0.642			NA											4	43					2.56e-06	2.88608e-06	0.009096	1	0
SNRNP70	6625	broad.mit.edu	37	19	49601690	49601690	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:49601690C>G	uc002pmk.2	+	5	711	c.272C>G	c.(271-273)CCT>CGT	p.P91R	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Missense_Mutation_p.P91R|SNRNP70_uc002pml.2_5'UTR|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	91					nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						ACAGGGGACCCTCACAATGAT	0.517			NA									OREG0025616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	170					0	0	0.002445	0	0
SLC17A7	57030	broad.mit.edu	37	19	49934685	49934685	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:49934685G>C	uc002pnp.2	-	10	1343	c.1171C>G	c.(1171-1173)CTG>GTG	p.L391V	SLC17A7_uc002pno.2_Intron	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	391	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		ACCAACAGCAGCGTGGCTTCC	0.582			NA											9	50					0	0	0.000978	0	0
RPL13A	23521	broad.mit.edu	37	19	49993733	49993733	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:49993733G>A	uc002pny.2	+	4	178	c.156G>A	c.(154-156)TTG>TTA	p.L52L	RPL13A_uc002pnz.2_5'UTR|RPL13A_uc002poa.2_Missense_Mutation_p.M42I|SNORD33_uc010emz.1_5'Flank|SNORD34_uc010ena.1_5'Flank|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555	P40429	RL13A_HUMAN	ribosomal protein L13a	52					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		TCTCCCTAGTGAAGTACCTGG	0.622			NA											7	53					0	0	0.001984	0	0
CPT1C	126129	broad.mit.edu	37	19	50195610	50195610	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:50195610C>G	uc002ppj.2	+	2	306	c.101C>G	c.(100-102)TCT>TGT	p.S34C	CPT1C_uc002ppl.3_Missense_Mutation_p.S34C|CPT1C_uc002ppi.2_5'UTR|CPT1C_uc002ppk.2_Missense_Mutation_p.S34C|CPT1C_uc010eng.2_Missense_Mutation_p.S34C|CPT1C_uc010enh.2_Missense_Mutation_p.S34C|CPT1C_uc010ybc.1_5'UTR	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	34	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		ATCTACCTCTCTGGCCTGCGC	0.622			NA											12	60					0	0	0.003163	0	0
ZNF473	25888	broad.mit.edu	37	19	50548106	50548106	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:50548106G>C	uc002prn.2	+	5	643	c.406G>C	c.(406-408)GAT>CAT	p.D136H	ZNF473_uc002prm.2_Missense_Mutation_p.D136H|ZNF473_uc010ybo.1_Missense_Mutation_p.D124H	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	136					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TCTGAGGTCTGATATTGCCAC	0.483			NA											9	56					0	0	0.001368	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52001316	52001316	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:52001316G>T	uc002pwx.1	-	5	1417	c.1361C>A	c.(1360-1362)TCC>TAC	p.S454Y	SIGLEC12_uc002pww.1_Missense_Mutation_p.S336Y|SIGLEC12_uc010eoy.1_Missense_Mutation_p.S181Y	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	454	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AATGTGCTGGGAGCCTAGAGG	0.592			NA											30	57					1.26612e-14	1.68983e-14	0.003271	1	0
ZNF845	91664	broad.mit.edu	37	19	53855364	53855364	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:53855364C>T	uc010ydv.1	+	4	1553	c.1436C>T	c.(1435-1437)ACA>ATA	p.T479I	ZNF845_uc010ydw.1_Missense_Mutation_p.T479I	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTT	0.378			NA											4	126					0	0	0.00308	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55377322	55377322	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:55377322C>A	uc002qhl.3	+	7	1126	c.1063C>A	c.(1063-1065)CTC>ATC	p.L355I	KIR3DL2_uc010esh.2_Missense_Mutation_p.L338I|KIR3DL2_uc002qho.3_Missense_Mutation_p.L355I			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	355	Helical; (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		cttcatcctcctcctcttctt	0.413			NA											22	27					1.50039e-11	1.90188e-11	0.001882	1	0
RPL28	6158	broad.mit.edu	37	19	55897779	55897779	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:55897779C>G	uc002qkv.2	+	2	96	c.54C>G	c.(52-54)ATC>ATG	p.I18M	uc002qku.2_5'Flank|RPL28_uc010yfz.1_Missense_Mutation_p.I18M|RPL28_uc010yfy.1_Missense_Mutation_p.I18M|RPL28_uc010yga.1_Missense_Mutation_p.I18M|RPL28_uc010ygb.1_Missense_Mutation_p.I18M|RPL28_uc002qkw.1_Missense_Mutation_p.I18M	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	18					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		GTTTCCTGATCAAGAGGAATA	0.607			NA											6	44					0	0	0.006214	0	0
U2AF2	11338	broad.mit.edu	37	19	56179919	56179919	+	Silent	SNP	C	C	T	rs80011152	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:56179919C>T	uc002qlu.2	+	8	1844	c.789C>T	c.(787-789)ATC>ATT	p.I263I	U2AF2_uc002qlt.2_Silent_p.I263I	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	263	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		AGCTGTTCATCGGGGGCTTAC	0.582			NA											9	88					0	0	0.008291	0	0
ZIM2	23619	broad.mit.edu	37	19	57290750	57290750	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:57290750C>A	uc002qnr.2	-	10	1119	c.737G>T	c.(736-738)TGT>TTT	p.C246F	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.C42F|ZIM2_uc010ygr.1_Missense_Mutation_p.C42F|ZIM2_uc002qnq.2_Missense_Mutation_p.C246F|ZIM2_uc010etp.2_Missense_Mutation_p.C246F|ZIM2_uc010ygs.1_Missense_Mutation_p.C246F	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	246	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CTCACCTTGACAAATCACTGT	0.517			NA											23	115					2.79863e-10	3.46481e-10	0.004656	1	0
ZNF154	7710	broad.mit.edu	37	19	58213694	58213694	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr19:58213694C>T	uc010euf.2	-	3	863	c.623G>A	c.(622-624)CGG>CAG	p.R208Q	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	208	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGAACTCTCCGGTGCTGAAT	0.438			NA											18	102					0	0	0.006122	0	0
ADAM17	6868	broad.mit.edu	37	2	9676042	9676042	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:9676042T>A	uc002qzu.2	-	4	554	c.371A>T	c.(370-372)GAC>GTC	p.D124V	ADAM17_uc010ewy.2_Missense_Mutation_p.D124V|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exb.1_Missense_Mutation_p.D124V|ADAM17_uc002qzv.2_Missense_Mutation_p.D124V	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	124					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		AACCCTAGAGTCAGGCTCACC	0.299			NA											4	37					0	0	0.009096	0	0
NBAS	51594	broad.mit.edu	37	2	15519904	15519904	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:15519904C>A	uc002rcc.1	-	30	3438	c.3412G>T	c.(3412-3414)GCT>TCT	p.A1138S	NBAS_uc010exl.1_Missense_Mutation_p.A210S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1138										ovary(2)|liver(1)|skin(1)	4						ATCTGTCCAGCCAGGTGGATG	0.443			NA											83	56					1.76565e-42	2.81445e-42	0.00361	1	0
MYCN	4613	broad.mit.edu	37	2	16086175	16086175	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:16086175C>G	uc002rci.2	+	3	1651	c.1351C>G	c.(1351-1353)CAG>GAG	p.Q451E	MYCN_uc010yjr.1_Missense_Mutation_p.Q443E	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	451	Leucine-zipper.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GCAGGCAAGACAGCAGCAGTT	0.458			NA	A		neuroblastoma								25	159					0	0	0.008361	0	0
WDR35	57539	broad.mit.edu	37	2	20175335	20175335	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:20175335C>A	uc002rdi.2	-	6	634	c.526G>T	c.(526-528)GCA>TCA	p.A176S	WDR35_uc002rdj.2_Missense_Mutation_p.A176S|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_5'UTR	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	176	WD 4.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCCATTTGCCATTCCAAAA	0.343			NA											22	11					2.37509e-13	3.1204e-13	0.010504	1	0
OTOF	9381	broad.mit.edu	37	2	26689665	26689665	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:26689665C>A	uc002rhk.2	-	36	4544	c.4417G>T	c.(4417-4419)GGC>TGC	p.G1473C	OTOF_uc010yla.1_Missense_Mutation_p.G203C|OTOF_uc002rhh.2_Missense_Mutation_p.G706C|OTOF_uc002rhi.2_Missense_Mutation_p.G783C|OTOF_uc002rhj.2_Missense_Mutation_p.G706C	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1473	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGTCGTAGCCGGCTTCCCGG	0.607	GBM(102;732 1451 20652 24062 31372)		NA											41	104					2.74695e-27	4.16793e-27	0.00361	1	0
FAM179A	165186	broad.mit.edu	37	2	29274845	29274845	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:29274845G>C	uc010ezl.2	+	20	3297	c.2946G>C	c.(2944-2946)ACG>ACC	p.T982T	FAM179A_uc010ymm.1_Silent_p.T927T|FAM179A_uc002rmr.3_Silent_p.T509T	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	982							binding			ovary(3)|skin(1)	4						TCCTCAAGACGCTCCAGGAAC	0.637			NA											4	16					0	0	0.009096	0	0
HEATR5B	54497	broad.mit.edu	37	2	37283652	37283652	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:37283652C>T	uc002rpp.1	-	16	2426	c.2330G>A	c.(2329-2331)GGA>GAA	p.G777E		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	777							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GACTGAGACTCCGAGAGGGAG	0.458			NA											34	94					0	0	0.00874	0	0
CDKL4	344387	broad.mit.edu	37	2	39431680	39431680	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:39431680C>G	uc002rrm.2	-	4	442	c.442G>C	c.(442-444)GCA>CCA	p.A148P	CDKL4_uc010fal.1_Missense_Mutation_p.A148P	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	148	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				AGAATTTGTGCAAACCCGAAG	0.284			NA											11	66					0	0	0.00245	0	0
REL	5966	broad.mit.edu	37	2	61144153	61144153	+	Splice_Site	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:61144153G>T	uc002sam.1	+	5	759	c.535_splice	c.e5+1	p.R179_splice	REL_uc002san.1_Splice_Site_p.R179_splice	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene						positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			TATGACAACCGTAAGTACTTC	0.274			NA	A		Hodgkin Lymphoma								31	42					2.40579e-17	3.34359e-17	0.00623	1	0
PROKR1	10887	broad.mit.edu	37	2	68882544	68882544	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:68882544C>G	uc010yqj.1	+	2	1018	c.1018C>G	c.(1018-1020)CTG>GTG	p.L340V	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	340	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						GATCAACACTCTGTGCTTCGT	0.507			NA											19	55					0	0	0.003954	0	0
DYSF	8291	broad.mit.edu	37	2	71892384	71892384	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:71892384G>C	uc002sie.2	+	46	5526	c.5150G>C	c.(5149-5151)CGG>CCG	p.R1717P	DYSF_uc010feg.2_Missense_Mutation_p.R1748P|DYSF_uc010feh.2_Missense_Mutation_p.R1724P|DYSF_uc002sig.3_Missense_Mutation_p.R1703P|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1738P|DYSF_uc010fef.2_Missense_Mutation_p.R1755P|DYSF_uc010fei.2_Missense_Mutation_p.R1734P|DYSF_uc010fek.2_Missense_Mutation_p.R1735P|DYSF_uc010fej.2_Missense_Mutation_p.R1725P|DYSF_uc010fel.2_Missense_Mutation_p.R1704P|DYSF_uc010feo.2_Missense_Mutation_p.R1749P|DYSF_uc010fem.2_Missense_Mutation_p.R1739P|DYSF_uc010fen.2_Missense_Mutation_p.R1756P|DYSF_uc002sif.2_Missense_Mutation_p.R1718P|DYSF_uc010yqy.1_Missense_Mutation_p.R598P|DYSF_uc010yqz.1_Missense_Mutation_p.R478P	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1717	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCTGTGTACCGGACAGACCGT	0.562			NA											34	105					0	0	0.005524	0	0
LBX2	85474	broad.mit.edu	37	2	74725136	74725136	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:74725136G>A	uc002slv.3	-	2	520	c.515C>T	c.(514-516)CCA>CTA	p.P172L	LBX2_uc002slw.2_Missense_Mutation_p.P168L	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	172						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCGGGATCTGGAGCGCCTTC	0.662			NA											15	56					0	0	0.001882	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745498	77745498	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:77745498C>A	uc002snr.2	-	3	1912	c.1497G>T	c.(1495-1497)TCG>TCT	p.S499S	LRRTM4_uc002snq.2_Silent_p.S499S|LRRTM4_uc002sns.2_Silent_p.S499S|LRRTM4_uc002snt.2_Silent_p.S500S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	499	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		ATCCATTAACCGATATATCCA	0.463			NA											10	11					0.000673444	0.000717534	0.008291	1	0
REG1A	5967	broad.mit.edu	37	2	79350055	79350055	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:79350055G>T	uc002snz.2	+	5	513	c.410G>T	c.(409-411)TGT>TTT	p.C137F	REG1A_uc010ysd.1_Missense_Mutation_p.C137F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	137	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCTGGCTACTGTGTGAGCCTG	0.567			NA											29	45					3.1745e-13	4.13833e-13	0.008361	1	0
CD8A	925	broad.mit.edu	37	2	87017616	87017617	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:87017616_87017617CC>AT	uc002srt.2	-	2	1126_1127	c.237_238GG>AT	c.(235-240)AAGGCG>AAATCG	p.A80S	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.A80S|CD8A_uc010ytn.1_Missense_Mutation_p.A121S|CD8A_uc002sru.2_Missense_Mutation_p.A80S	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	80	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CCCTCGGCCGCCTTGGGCTTGT	0.663			NA											28	101					0	0	0.004672	0	0
VWA3B	200403	broad.mit.edu	37	2	98852870	98852870	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:98852870G>T	uc002syo.2	+	18	2710	c.2446G>T	c.(2446-2448)GCT>TCT	p.A816S	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.A335S|VWA3B_uc002sym.2_Missense_Mutation_p.A816S|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.A473S|VWA3B_uc002syp.1_Missense_Mutation_p.A208S|VWA3B_uc002syq.1_Missense_Mutation_p.A92S|VWA3B_uc002syr.1_Missense_Mutation_p.A133S|VWA3B_uc010fih.1_5'Flank	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	816										ovary(3)|large_intestine(2)|skin(1)	6						CATCTTGCTGGCTGAGGAGTG	0.443			NA											28	108					6.84511e-11	8.57977e-11	0.003271	1	0
UNC50	25972	broad.mit.edu	37	2	99234748	99234748	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:99234748A>G	uc002szc.3	+	6	913	c.761A>G	c.(760-762)TAT>TGT	p.Y254C	C2orf64_uc002sza.2_Intron|UNC50_uc002szb.2_Missense_Mutation_p.Y254C|UNC50_uc010yvl.1_Missense_Mutation_p.Y271C	NM_014044	NP_054763	Q53HI1	UNC50_HUMAN	unc-50 homolog	254	Lumenal (Potential).				protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding				0						TGTTCTTTCTATAAGTACAGA	0.368			NA											8	43					0	0	0.000978	0	0
GPR45	11250	broad.mit.edu	37	2	105858897	105858897	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:105858897C>G	uc002tco.1	+	1	698	c.582C>G	c.(580-582)GCC>GCG	p.A194A		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	194	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CTGACCGCGCCTACGTGGTCA	0.692			NA											19	15					0	0	0.008871	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107423223	107423223	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:107423223C>G	uc002tdq.2	-	6	1620	c.1501G>C	c.(1501-1503)GGG>CGG	p.G501R	ST6GAL2_uc002tdr.2_Missense_Mutation_p.G501R	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	501	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TGCAAATCCCCCTGCGTGCCC	0.587			NA											46	38					0	0	0.00361	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626829	108626829	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:108626829C>A	uc002tdv.2	+	9	1531	c.1255C>A	c.(1255-1257)CCC>ACC	p.P419T	SLC5A7_uc010ywm.1_Missense_Mutation_p.P172T|SLC5A7_uc010fjj.2_Missense_Mutation_p.P419T|SLC5A7_uc010ywn.1_Missense_Mutation_p.P306T	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	419	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CGTTATCTTCCCCCAGCTGCT	0.502			NA											25	57					3.11337e-16	4.2682e-16	0.002836	1	0
GCC2	9648	broad.mit.edu	37	2	109085530	109085530	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:109085530A>T	uc002tec.2	+	5	465	c.311A>T	c.(310-312)CAA>CTA	p.Q104L	GCC2_uc002ted.2_Missense_Mutation_p.Q3L	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	104					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAAATGAAGCAAGAGGTTGAG	0.313			NA											20	54					0	0	0.00333	0	0
MERTK	10461	broad.mit.edu	37	2	112751865	112751865	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:112751865G>T	uc002thk.1	+	9	1456	c.1334G>T	c.(1333-1335)CGA>CTA	p.R445L	MERTK_uc002thl.1_Missense_Mutation_p.R269L	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	445	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						AATGGCAGCCGAGCTCGGATC	0.527			NA											61	128					7.75977e-34	1.20827e-33	0.00361	1	0
DDX18	8886	broad.mit.edu	37	2	118575196	118575196	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:118575196C>A	uc002tlh.1	+	2	361	c.262C>A	c.(262-264)CAG>AAG	p.Q88K		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	88							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AAAGTCTCCCCAGAAATCCAC	0.363			NA											9	100					2.17888e-05	2.40535e-05	0.006214	1	0
CFC1B	653275	broad.mit.edu	37	2	131356263	131356263	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:131356263C>T	uc002tro.1	-	3	590	c.199G>A	c.(199-201)GGC>AGC	p.G67S		NM_001079530	NP_001072998	P0CG36	CFC1B_HUMAN	cripto, FRL-1, cryptic family 1B	67					gastrulation	extracellular region					0	Colorectal(110;0.1)					GGCCCCCAGCCCTCGGCGCTC	0.632			NA											19	53					0	0	0.002836	0	0
FAM123C	205147	broad.mit.edu	37	2	131521517	131521517	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:131521517A>T	uc002trw.2	+	2	2062	c.1872A>T	c.(1870-1872)ACA>ACT	p.T624T	FAM123C_uc010fmv.2_Silent_p.T624T|FAM123C_uc010fms.1_Silent_p.T624T|FAM123C_uc010fmt.1_Silent_p.T624T|FAM123C_uc010fmu.1_Silent_p.T624T	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	624										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CTTCGACAACAGATACTTCCG	0.582			NA											17	35					0	0	0.010504	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131796570	131796570	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:131796570G>A	uc002tsa.1	+	6	1232	c.712G>A	c.(712-714)GAT>AAT	p.D238N	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.D238N|ARHGEF4_uc010fmx.1_Missense_Mutation_p.D238N|ARHGEF4_uc002tsc.1_5'Flank	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	238	SH3.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CCGGGTCGCCGATGGCGAGGG	0.592			NA											4	36					0	0	0.001168	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240245	132240245	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:132240245C>G	uc002tsu.3	+	5	1284	c.1177C>G	c.(1177-1179)CAT>GAT	p.H393D		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	393					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CCGCCTGGACCATAAGTTCGA	0.652	Ovarian(137;2059 2432 35543 39401)		NA											26	172					0	0	0.005443	0	0
R3HDM1	23518	broad.mit.edu	37	2	136389479	136389479	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:136389479A>G	uc002tuo.2	+	9	976	c.606A>G	c.(604-606)CTA>CTG	p.L202L	R3HDM1_uc010fni.2_Silent_p.L200L|R3HDM1_uc002tup.2_Silent_p.L146L|R3HDM1_uc010zbh.1_Silent_p.L34L	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	202	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		ATAGGATGCTATTACACAGAG	0.393			NA											27	149					0	0	0.008361	0	0
MCM6	4175	broad.mit.edu	37	2	136609035	136609035	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:136609035C>A	uc002tuw.2	-	13	1930	c.1854G>T	c.(1852-1854)GTG>GTT	p.V618V		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	618					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CAAGCTGTCGCACTGTAATCC	0.458	Ovarian(196;141 2104 8848 24991 25939)		NA											27	18					1.74807e-11	2.21305e-11	0.002096	1	0
LRP1B	53353	broad.mit.edu	37	2	141762928	141762928	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:141762928C>A	uc002tvj.1	-	15	3451	c.2479G>T	c.(2479-2481)GAT>TAT	p.D827Y	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	827	Extracellular (Potential).|EGF-like 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCATTTTCATCCAAAAGTTGA	0.428	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	44					2.0095e-06	2.27053e-06	0.001984	1	0
ARHGAP15	55843	broad.mit.edu	37	2	143913201	143913201	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:143913201G>T	uc002tvm.3	+	2	293	c.142G>T	c.(142-144)GAT>TAT	p.D48Y	ARHGAP15_uc010zbl.1_Missense_Mutation_p.D48Y	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	48					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GATCCTCACCGATGTCGGGAA	0.423			NA											22	59					2.27525e-19	3.23342e-19	0.003954	1	0
RIF1	55183	broad.mit.edu	37	2	152319895	152319895	+	Silent	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:152319895A>C	uc002txm.2	+	30	3991	c.3861A>C	c.(3859-3861)TCA>TCC	p.S1287S	RIF1_uc002txl.2_Silent_p.S1287S|RIF1_uc002txn.2_Silent_p.S1287S|RIF1_uc002txo.2_Silent_p.S1287S|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1287					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CTAAGAGATCAAGCCGGAGAG	0.378			NA											7	80					0	0	0.004482	0	0
NEB	4703	broad.mit.edu	37	2	152487259	152487259	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:152487259C>A	uc010fnx.2	-	63	9155	c.8964G>T	c.(8962-8964)TTG>TTT	p.L2988F	NEB_uc002txu.2_Missense_Mutation_p.L335F	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2988	Nebulin 81.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTGCCTTGCCAACATAATCT	0.398			NA											3	11					0.00909568	0.00941286	0.009096	1	0
NEB	4703	broad.mit.edu	37	2	152506830	152506830	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:152506830C>G	uc010fnx.2	-	54	7482	c.7291G>C	c.(7291-7293)GAG>CAG	p.E2431Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2431	Nebulin 65.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTTCTGCCTCTAAAGAACCC	0.453			NA											18	74					0	0	0.00278	0	0
TANC1	85461	broad.mit.edu	37	2	160007013	160007013	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:160007013G>A	uc002uag.2	+	7	902	c.628G>A	c.(628-630)GAG>AAG	p.E210K	TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Missense_Mutation_p.E209K|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_3'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	210	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAGTCCCTGTGAGACCATTAG	0.502			NA											11	87					0	0	0.000978	0	0
DPP4	1803	broad.mit.edu	37	2	162894883	162894883	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:162894883G>A	uc002ubz.2	-	8	1103	c.542C>T	c.(541-543)CCA>CTA	p.P181L	DPP4_uc010fpb.2_5'UTR|DPP4_uc002uca.1_RNA|DPP4_uc002ucb.1_RNA	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	181	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TCTGTAACTTGGTAAATTTGG	0.289			NA											5	47					0	0	0.000602	0	0
GCG	2641	broad.mit.edu	37	2	163003990	163003990	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:163003990C>A	uc002ucc.2	-	3	226	c.127G>T	c.(127-129)GAT>TAT	p.D43Y		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	43					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	TGATCAGGATCACTGAGTGGG	0.483			NA											47	262					3.10202e-16	4.25842e-16	0.00361	1	0
KCNH7	90134	broad.mit.edu	37	2	163360955	163360955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:163360955G>A	uc002uch.1	-	6	1338	c.1126C>T	c.(1126-1128)CAG>TAG	p.Q376*	KCNH7_uc002uci.2_Nonsense_Mutation_p.Q369*	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	376	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGTCCTACCTGGGTCACTTTC	0.358	GBM(196;1492 2208 17507 24132 45496)		NA											23	119					0	0	0.00632	0	0
TTC21B	79809	broad.mit.edu	37	2	166769059	166769059	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:166769059C>A	uc002udk.2	-	17	2420	c.2287G>T	c.(2287-2289)GGC>TGC	p.G763C		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	763	TPR 10.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						AGTGCTTTGCCCATTTTGCTT	0.363			NA											15	194					3.45872e-05	3.80572e-05	0.004007	1	0
STK39	27347	broad.mit.edu	37	2	168921829	168921829	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:168921829C>A	uc002uea.2	-	13	1465	c.1305G>T	c.(1303-1305)CAG>CAT	p.Q435H		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	435					response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						AGAAACATACCTGAGAGTCGT	0.453			NA											91	77					4.00015e-43	6.38631e-43	0.00361	1	0
SSB	6741	broad.mit.edu	37	2	170657490	170657490	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:170657490A>T	uc002ufk.2	+	2	127	c.20A>T	c.(19-21)AAT>ATT	p.N7I	SSB_uc002ufl.2_Missense_Mutation_p.N7I|SSB_uc002ufm.2_Missense_Mutation_p.N7I	NM_003142	NP_003133	P05455	LA_HUMAN	autoantigen La	7	HTH La-type RNA-binding.				histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4						AATGGTGATAATGAAAAGATG	0.328			NA											28	76					0	0	0.004878	0	0
GORASP2	26003	broad.mit.edu	37	2	171812965	171812965	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:171812965A>T	uc002ugk.2	+	7	859	c.719A>T	c.(718-720)AAT>ATT	p.N240I	GORASP2_uc002ugj.2_Missense_Mutation_p.N172I|GORASP2_uc010zdl.1_Missense_Mutation_p.N252I|GORASP2_uc010zdm.1_Missense_Mutation_p.N196I|GORASP2_uc002ugl.2_Missense_Mutation_p.N172I|GORASP2_uc002ugm.2_Missense_Mutation_p.N22I	NM_015530	NP_056345	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2	240						Golgi membrane				breast(1)|central_nervous_system(1)	2						TCCTCAGTTAATCCCCCGTCT	0.388			NA											9	73					0	0	0.008291	0	0
SP3	6670	broad.mit.edu	37	2	174820238	174820238	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:174820238G>C	uc002uig.2	-	4	1166	c.1002C>G	c.(1000-1002)TCC>TCG	p.S334S	SP3_uc002uie.2_Silent_p.S266S|SP3_uc002uif.2_Silent_p.S281S|SP3_uc010zel.1_Silent_p.S331S	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	334					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			GTGATGAAGAGGATGTTGGCA	0.378			NA											23	144					0	0	0.002445	0	0
CHRNA1	1134	broad.mit.edu	37	2	175614771	175614771	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:175614771A>G	uc002ujd.2	-	8	1058	c.980T>C	c.(979-981)ATG>ACG	p.M327T	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.M302T	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	327	Helical.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACGAACACCATGGTGAACAG	0.527			NA											19	125					0	0	0.010504	0	0
MTX2	10651	broad.mit.edu	37	2	177134358	177134358	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:177134358A>G	uc002ukx.2	+	1	236	c.1A>G	c.(1-3)ATG>GTG	p.M1V	MTX2_uc002ukw.2_5'UTR	NM_006554	NP_006545	O75431	MTX2_HUMAN	metaxin 2	1					protein targeting to mitochondrion	mitochondrial outer membrane				ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00365)|Epithelial(96;0.0654)|all cancers(119;0.181)			CCCAGCCGACATGTCTCTAGT	0.716			NA											5	2					0	0	0.006214	0	0
PRKRA	8575	broad.mit.edu	37	2	179315099	179315099	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179315099C>T	uc002umf.2	-	2	306	c.105G>A	c.(103-105)CCG>CCA	p.P35P	PRKRA_uc002umd.2_Silent_p.P10P|PRKRA_uc002ume.2_Silent_p.P24P|PRKRA_uc002umg.2_5'UTR|DFNB59_uc002umi.3_5'Flank	NM_003690	NP_003681	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double	35	Sufficient for self-association and interaction with TARBP2.|DRBM 1.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			ATACCTGAATCGGTGTTTTCC	0.428	Melanoma(200;68 3001 23825 48764)		NA											31	345					0	0	0.004878	0	0
TTN	7273	broad.mit.edu	37	2	179414326	179414326	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179414326G>A	uc010zfg.1	-	287	84643	c.84419C>T	c.(84418-84420)TCT>TTT	p.S28140F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S21835F|TTN_uc010zfi.1_Missense_Mutation_p.S21768F|TTN_uc010zfj.1_Missense_Mutation_p.S21643F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29067							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGGATCAGAATCAAGTGG	0.378			NA											20	154					0	0	0.00278	0	0
TTN	7273	broad.mit.edu	37	2	179434805	179434805	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179434805T>C	uc010zfg.1	-	275	68574	c.68350A>G	c.(68350-68352)ACA>GCA	p.T22784A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T16479A|TTN_uc010zfi.1_Missense_Mutation_p.T16412A|TTN_uc010zfj.1_Missense_Mutation_p.T16287A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23711							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCATCTTGTCCATCTAATG	0.428			NA											11	54					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179437740	179437740	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179437740G>T	uc010zfg.1	-	275	65639	c.65415C>A	c.(65413-65415)GTC>GTA	p.V21805V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V15500V|TTN_uc010zfi.1_Silent_p.V15433V|TTN_uc010zfj.1_Silent_p.V15308V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22732							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTGGAGTGACAATCTGCC	0.448			NA											8	29					2.27111e-07	2.61891e-07	0.001368	1	0
TTN	7273	broad.mit.edu	37	2	179600657	179600657	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179600657G>T	uc010zfg.1	-	47	11008	c.10784C>A	c.(10783-10785)CCT>CAT	p.P3595H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P256H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4522							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCAGTTAGGTGAAGGTGA	0.438			NA											23	70					1.61788e-16	2.22403e-16	0.002445	1	0
TTN	7273	broad.mit.edu	37	2	179638309	179638309	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:179638309G>C	uc010zfg.1	-	32	7698	c.7474C>G	c.(7474-7476)CAG>GAG	p.Q2492E	TTN_uc010zfh.1_Missense_Mutation_p.Q2446E|TTN_uc010zfi.1_Missense_Mutation_p.Q2446E|TTN_uc010zfj.1_Missense_Mutation_p.Q2446E|TTN_uc002unb.2_Missense_Mutation_p.Q2492E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2492							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAATGGCCTGTACACGGTCA	0.443			NA											13	98					0	0	0.003163	0	0
CWC22	57703	broad.mit.edu	37	2	180818938	180818938	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:180818938T>C	uc010frh.1	-	16	1983	c.1683A>G	c.(1681-1683)CCA>CCG	p.P561P	CWC22_uc002uno.2_Silent_p.P83P|CWC22_uc002unp.2_Silent_p.P561P	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	561	MI.					catalytic step 2 spliceosome	protein binding|RNA binding				0						TTACACTCCATGGAAGTGAAT	0.343			NA											14	41					0	0	0.00499	0	0
NEUROD1	4760	broad.mit.edu	37	2	182542546	182542546	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:182542546C>A	uc002uof.2	-	2	1278	c.1042G>T	c.(1042-1044)GCC>TCC	p.A348S	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	348					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTGAGCTGGGCACTCATGACT	0.493			NA											59	120					1.7104e-27	2.59908e-27	0.00361	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802271	185802271	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:185802271A>C	uc002uph.2	+	4	2742	c.2148A>C	c.(2146-2148)TTA>TTC	p.L716F		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	716						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AACATAATTTAACATATTCTA	0.313			NA											4	32					0	0	0.009096	0	0
COL3A1	1281	broad.mit.edu	37	2	189876385	189876385	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:189876385T>C	uc002uqj.1	+	51	4403	c.4286T>C	c.(4285-4287)TTT>TCT	p.F1429S		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1429	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAAACAGTCTTTGAATATCGA	0.403			NA											20	83					0	0	0.005443	0	0
COL5A2	1290	broad.mit.edu	37	2	189909940	189909940	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:189909940C>G	uc002uqk.2	-	47	3603	c.3328G>C	c.(3328-3330)GGA>CGA	p.G1110R	COL5A2_uc010frx.2_Missense_Mutation_p.G686R	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1110					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGGTGGTCCTATAGGACCC	0.323			NA											13	18					0	0	0.007413	0	0
DNAH7	56171	broad.mit.edu	37	2	196865601	196865601	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:196865601C>T	uc002utj.3	-	12	1281	c.1180G>A	c.(1180-1182)GTT>ATT	p.V394I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	394	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAAGCTCTAACAGAATCCTGC	0.333			NA											18	42					0	0	0.007413	0	0
HECW2	57520	broad.mit.edu	37	2	197143300	197143300	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:197143300C>A	uc002utm.1	-	15	3270	c.3087G>T	c.(3085-3087)CTG>CTT	p.L1029L	HECW2_uc002utl.1_Silent_p.L673L	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1029	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GCCGATGAACCAGCGCACTTG	0.532			NA											28	74					7.38237e-10	9.08391e-10	0.00632	1	0
BMPR2	659	broad.mit.edu	37	2	203424452	203424452	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:203424452C>T	uc002uzf.3	+	13	4048	c.2900C>T	c.(2899-2901)TCA>TTA	p.S967L	BMPR2_uc010ftr.2_3'UTR	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	967	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AAATCAGGATCAGGTGAAAAG	0.428			NA											13	25					0	0	0.001855	0	0
BMPR2	659	broad.mit.edu	37	2	203424547	203424547	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:203424547G>T	uc002uzf.3	+	13	4143	c.2995G>T	c.(2995-2997)GAA>TAA	p.E999*	BMPR2_uc010ftr.2_3'UTR	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	999	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						GCTGGACTGTGAAGTCAACAA	0.483			NA											17	51					4.35082e-09	5.23863e-09	0.010504	1	0
UNC80	285175	broad.mit.edu	37	2	210642157	210642157	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:210642157A>T	uc010zjc.1	+	4	554	c.474A>T	c.(472-474)CCA>CCT	p.P158P	UNC80_uc002vdj.1_Silent_p.P158P	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	158						integral to membrane					0						AGGGTTCTCCAGGGCAGCCTT	0.527			NA											31	25					0	0	0.009535	0	0
CPS1	1373	broad.mit.edu	37	2	211454856	211454856	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:211454856C>T	uc002vee.3	+	8	870	c.738C>T	c.(736-738)CCC>CCT	p.P246P	CPS1_uc010fur.2_Silent_p.P252P	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	246	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		ACTTAGTTCCCTGGAACCATG	0.423			NA											42	172					0	0	0.00361	0	0
CPS1	1373	broad.mit.edu	37	2	211504764	211504764	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:211504764C>A	uc002vee.3	+	24	3072	c.2940C>A	c.(2938-2940)GGC>GGA	p.G980G	CPS1_uc010fur.2_Silent_p.G986G|CPS1_uc010fus.2_Silent_p.G529G	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	980					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGTGCTAGGCTGTGGTCCAT	0.224			NA											26	70					4.65686e-17	6.44551e-17	0.003755	1	0
ERBB4	2066	broad.mit.edu	37	2	212295709	212295709	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:212295709C>G	uc002veg.1	-	21	2702	c.2604G>C	c.(2602-2604)TTG>TTC	p.L868F	ERBB4_uc002veh.1_Missense_Mutation_p.L868F|ERBB4_uc010zji.1_Missense_Mutation_p.L858F|ERBB4_uc010zjj.1_Missense_Mutation_p.L858F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	868	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CATCTCCTTCCAAGAGTCTGG	0.398			NA								TSP Lung(8;0.080)			15	90					0	0	0.008871	0	0
ERBB4	2066	broad.mit.edu	37	2	212568860	212568860	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:212568860G>T	uc002veg.1	-	11	1356	c.1258C>A	c.(1258-1260)CTG>ATG	p.L420M	ERBB4_uc002veh.1_Missense_Mutation_p.L420M|ERBB4_uc010zji.1_Missense_Mutation_p.L420M|ERBB4_uc010zjj.1_Missense_Mutation_p.L420M|ERBB4_uc010fut.1_Missense_Mutation_p.L420M	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	420	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATGGTCACCAGGTTAGAAAAA	0.393			NA								TSP Lung(8;0.080)			9	90					9.05144e-12	1.1546e-11	0.001855	1	0
CRYBA2	1412	broad.mit.edu	37	2	219855051	219855051	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:219855051C>G	uc002vjj.1	-	5	552	c.517G>C	c.(517-519)GAG>CAG	p.E173Q	CRYBA2_uc002vjk.1_Missense_Mutation_p.E173Q	NM_057094	NP_476435	P53672	CRBA2_HUMAN	crystallin, beta A2	173	Beta/gamma crystallin 'Greek key' 4.						structural constituent of eye lens				0		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTACAGAACTCTCCGCTGTGC	0.632			NA											12	81					0	0	0.00245	0	0
PTPRN	5798	broad.mit.edu	37	2	220162135	220162135	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:220162135C>A	uc002vkz.2	-	14	1997	c.1908G>T	c.(1906-1908)ATG>ATT	p.M636I	PTPRN_uc010zlc.1_Missense_Mutation_p.M546I|PTPRN_uc002vla.2_Missense_Mutation_p.M607I	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	636	Cytoplasmic (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		ACTTCGTGGCCATGTGCTGGC	0.612			NA											51	41					4.33383e-22	6.34664e-22	0.00361	1	0
STK11IP	114790	broad.mit.edu	37	2	220473406	220473406	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:220473406G>A	uc002vml.2	+	15	1781	c.1738G>A	c.(1738-1740)GTG>ATG	p.V580M	STK11IP_uc010zll.1_Missense_Mutation_p.V537M|STK11IP_uc002vmm.1_Missense_Mutation_p.V569M	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	580	Glu-rich.				protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGTTTGAGGTGGAACTCCA	0.642			NA											7	25					0	0	0.00308	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505639	220505639	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:220505639G>T	uc002vmp.3	+	22	3845	c.3576G>T	c.(3574-3576)AGG>AGT	p.R1192S	SLC4A3_uc002vmo.3_Missense_Mutation_p.R1219S|SLC4A3_uc010fwm.2_Missense_Mutation_p.R742S	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	1192	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCCTCTGAGGCATTGCCTTC	0.607			NA											17	60					1.67942e-08	2.01012e-08	0.006122	1	0
SERPINE2	5270	broad.mit.edu	37	2	224866523	224866523	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:224866523G>T	uc002vnu.2	-	2	338	c.95C>A	c.(94-96)TCC>TAC	p.S32Y	SERPINE2_uc002vnt.2_Missense_Mutation_p.S32Y|SERPINE2_uc010zlr.1_Missense_Mutation_p.S44Y|SERPINE2_uc002vnv.2_Missense_Mutation_p.S32Y	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	32					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CCCCGTGTTGGAGCCTAGTTC	0.547			NA											23	133					3.08376e-08	3.65631e-08	0.00333	1	0
DOCK10	55619	broad.mit.edu	37	2	225635044	225635044	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:225635044G>T	uc010fwz.1	-	55	6567	c.6328C>A	c.(6328-6330)CAG>AAG	p.Q2110K	DOCK10_uc002vob.2_Missense_Mutation_p.Q2104K|DOCK10_uc002voa.2_Missense_Mutation_p.Q766K	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2110	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCAAGGGCCTGCCCACATGCA	0.507			NA											8	12					1.08611e-07	1.26254e-07	0.000978	1	0
KIAA1486	57624	broad.mit.edu	37	2	226447034	226447034	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:226447034G>T	uc002voe.2	+	4	1076	c.901G>T	c.(901-903)GTG>TTG	p.V301L	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.V71L	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	301										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		TACTCCCACGGTGCCTGACTT	0.572			NA											14	64					1.3612e-06	1.55017e-06	0.003163	1	0
IRS1	3667	broad.mit.edu	37	2	227663346	227663346	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:227663346C>T	uc002voh.3	-	1	161	c.109G>A	c.(109-111)GAG>AAG	p.E37K		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	37	PH.|Mediates interaction with PHIP (By similarity).				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CCCCCAGCCTCGCTGGCCGCG	0.647			NA											12	75					0	0	0.003163	0	0
COL4A4	1286	broad.mit.edu	37	2	227953497	227953497	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:227953497T>C	uc010zlt.1	-	22	2149	c.1495A>G	c.(1495-1497)ATG>GTG	p.M499V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	499	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGGGGGCCCATGGGTCCAGGC	0.552			NA											13	63					0	0	0.00499	0	0
TRIP12	9320	broad.mit.edu	37	2	230633405	230633405	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:230633405G>A	uc002vpw.1	-	40	5818	c.5709C>T	c.(5707-5709)CTC>CTT	p.L1903L	TRIP12_uc002vpx.1_Silent_p.L1951L|TRIP12_uc002vpy.1_Silent_p.L1633L	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1903	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CAAAACTACTGAGAATCTCAA	0.373			NA											6	32					0	0	0.001984	0	0
ALPP	250	broad.mit.edu	37	2	233245181	233245181	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:233245181C>A	uc002vsq.2	+	7	1009	c.844C>A	c.(844-846)CCG>ACG	p.P282T	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	282						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TTCCCTGGACCCGTCTGTGAC	0.637			NA											22	91					8.4185e-14	1.11327e-13	0.002445	1	0
ECEL1	9427	broad.mit.edu	37	2	233349546	233349546	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:233349546C>A	uc002vsv.2	-	5	1229	c.1024G>T	c.(1024-1026)GTG>TTG	p.V342L	ECEL1_uc010fya.1_Missense_Mutation_p.V342L|ECEL1_uc010fyb.1_Missense_Mutation_p.V49L	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	342	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCCAGCGTCACCTTGTTGTAC	0.602			NA											20	113					2.61193e-14	3.47225e-14	0.009535	1	0
CHRNG	1146	broad.mit.edu	37	2	233409292	233409292	+	Splice_Site	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:233409292T>G	uc002vsx.1	+	10	1270	c.1249_splice	c.e10+2	p.E417_splice	CHRNG_uc010fye.1_Splice_Site_p.E365_splice	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma						muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		AGAAGCTAGGTGAGACACACC	0.662			NA											7	29					0	0	0.004482	0	0
GIGYF2	26058	broad.mit.edu	37	2	233655812	233655812	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:233655812A>G	uc002vti.3	+	13	1362	c.1025A>G	c.(1024-1026)AAT>AGT	p.N342S	GIGYF2_uc010zmj.1_Missense_Mutation_p.N342S|GIGYF2_uc002vtg.2_Missense_Mutation_p.N336S|GIGYF2_uc002vtj.3_Missense_Mutation_p.N364S|GIGYF2_uc002vtk.3_Missense_Mutation_p.N342S|GIGYF2_uc002vth.3_Missense_Mutation_p.N336S|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.N173S	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	342					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GGTAGCCATAATGAAGAGGCC	0.468			NA											13	20					0	0	0.003163	0	0
USP40	55230	broad.mit.edu	37	2	234442344	234442344	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:234442344C>A	uc010zmr.1	-	10	1285	c.1285G>T	c.(1285-1287)GCT>TCT	p.A429S	USP40_uc010zmt.1_Missense_Mutation_p.A73S	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	417					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TCAGACTCAGCCTGGAGAGAA	0.403			NA											6	25					3.59834e-05	3.95073e-05	0.001168	1	0
UGT1A3	54659	broad.mit.edu	37	2	234637790	234637790	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:234637790G>T	uc002vuy.2	+	1	18	c.18G>T	c.(16-18)CAG>CAT	p.Q6H	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.Q6H	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	6					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CAGGACTCCAGGTTCCCCTGC	0.572			NA									OREG0003835	type=REGULATORY REGION|Gene=UGT1A3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	82					0.000151284	0.000164489	0.001855	1	0
DNAJB3	414061	broad.mit.edu	37	2	234652454	234652454	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:234652454C>A	uc002vuz.2	-	1	208	c.109G>T	c.(109-111)GAG>TAG	p.E37*	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	37	J.				protein folding		heat shock protein binding|unfolded protein binding				0						TCCTTGTTCTCAGGGTTTTTG	0.597			NA											25	122					1.80694e-10	2.2481e-10	0.009535	1	0
COL6A3	1293	broad.mit.edu	37	2	238270446	238270446	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:238270446C>A	uc002vwl.2	-	15	6377	c.6092G>T	c.(6091-6093)GGG>GTG	p.G2031V	COL6A3_uc002vwo.2_Missense_Mutation_p.G1825V|COL6A3_uc010znj.1_Missense_Mutation_p.G1424V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2031	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCAGGGAACCCCACAGCAAGC	0.537			NA											31	55					6.97489e-18	9.77453e-18	0.004878	1	0
COL6A3	1293	broad.mit.edu	37	2	238275874	238275874	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:238275874C>A	uc002vwl.2	-	11	5241	c.4956G>T	c.(4954-4956)AGG>AGT	p.R1652S	COL6A3_uc002vwo.2_Missense_Mutation_p.R1446S|COL6A3_uc010znj.1_Missense_Mutation_p.R1045S	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1652	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAAACTGTCCCTCCTGAAGT	0.433			NA											14	19					1.15088e-07	1.33475e-07	0.004007	1	0
KLHL30	377007	broad.mit.edu	37	2	239057733	239057733	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr2:239057733C>T	uc002vxr.1	+	6	1404	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	475	Kelch 5.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		AGCTCTACCTCATTGGGGACA	0.657			NA											6	26					0	0	0.001984	0	0
SOX12	6666	broad.mit.edu	37	20	307448	307448	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:307448G>A	uc002wdh.2	+	1	1210	c.880G>A	c.(880-882)GAG>AAG	p.E294K		NM_006943	NP_008874	O15370	SOX12_HUMAN	SRY (sex determining region Y)-box 12	294					cell fate commitment|spinal cord development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|transcription regulatory region sequence-specific DNA binding				0		all_cancers(10;0.000331)|Lung NSC(37;0.0496)|all_lung(30;0.0831)|all_epithelial(17;0.0868)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CTGCACCCCCGAGGTTACCGA	0.697			NA											11	55					0	0	0.00245	0	0
ZNF343	79175	broad.mit.edu	37	20	2463909	2463909	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:2463909G>A	uc002wge.1	-	6	2186	c.1698C>T	c.(1696-1698)GTC>GTT	p.V566V	ZNF343_uc010gao.1_Silent_p.V566V|ZNF343_uc002wgd.1_Silent_p.V476V	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	566	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCCTCTGGTGGACAAGGAGGA	0.507			NA											6	79					0	0	0.001168	0	0
ADAM33	80332	broad.mit.edu	37	20	3653514	3653515	+	Nonsense_Mutation	DNP	TG	TG	CT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:3653514_3653515TG>CT	uc002wit.2	-	12	1251_1252	c.1164_1165CA>AG	c.(1162-1167)TGCAGC>TGAGGC	p.388_389CS>*G	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Nonsense_Mutation_p.388_389CS>*G|ADAM33_uc002wis.2_5'UTR|ADAM33_uc002wiu.2_Nonsense_Mutation_p.388_389CS>*G|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_3'UTR|ADAM33_uc010zqh.1_3'UTR	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	388_389	Extracellular (Potential).|Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TGGCGGCGGCTGCAGGCGCTGA	0.728			NA											21	9					0	0	0.004672	0	0
CDS2	8760	broad.mit.edu	37	20	5167438	5167438	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:5167438C>T	uc002wls.2	+	10	1191	c.934C>T	c.(934-936)CTG>TTG	p.L312L	CDS2_uc002wlr.1_Silent_p.L234L|CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Silent_p.L257L|CDS2_uc010zqu.1_Silent_p.L192L|CDS2_uc002wlv.2_Silent_p.L214L|CDS2_uc010zqv.1_Intron	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	312					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						CCTGTTTCGCCTGCAGGAGTA	0.547			NA											139	44					0	0	0.00361	0	0
PLCB1	23236	broad.mit.edu	37	20	8609011	8609011	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:8609011T>A	uc002wnb.2	+	4	320	c.317T>A	c.(316-318)GTG>GAG	p.V106E	PLCB1_uc010zrb.1_Missense_Mutation_p.V5E|PLCB1_uc010gbv.1_Missense_Mutation_p.V106E|PLCB1_uc002wmz.1_Missense_Mutation_p.V106E|PLCB1_uc002wna.2_Missense_Mutation_p.V106E|PLCB1_uc002wnc.1_Missense_Mutation_p.V5E	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	106					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ATCACAGTGGTGTATGGGCCT	0.458			NA											15	109					0	0	0.004007	0	0
C20orf26	26074	broad.mit.edu	37	20	20037345	20037345	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:20037345C>A	uc002wru.2	+	2	124	c.48C>A	c.(46-48)TGC>TGA	p.C16*	C20orf26_uc010gcw.1_Intron|C20orf26_uc010zse.1_Nonsense_Mutation_p.C16*|C20orf26_uc010zsf.1_Nonsense_Mutation_p.C16*|CRNKL1_uc002wrs.2_5'Flank|CRNKL1_uc002wrt.1_5'Flank	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	16										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TTGTTCATTGCCGAAGAACAG	0.353			NA											64	20					3.98521e-19	5.64758e-19	0.00361	1	0
C20orf26	26074	broad.mit.edu	37	20	20279030	20279030	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:20279030G>C	uc002wru.2	+	25	3498	c.3422G>C	c.(3421-3423)AGC>ACC	p.S1141T	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1141										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GATCTCTATAGGTGAGTTGGA	0.463			NA											38	10					0	0	0.00623	0	0
SSTR4	6754	broad.mit.edu	37	20	23016324	23016324	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:23016324C>G	uc002wsr.2	+	1	268	c.204C>G	c.(202-204)GTC>GTG	p.V68V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	68	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ACGCCCTGGTCATCTTCGTGA	0.507	Esophageal Squamous(15;850 1104 16640)		NA											31	183					0	0	0.005524	0	0
ZNF341	84905	broad.mit.edu	37	20	32328721	32328721	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:32328721G>T	uc002wzy.2	+	2	65	c.45G>T	c.(43-45)CAG>CAT	p.Q15H	ZNF341_uc002wzx.2_Missense_Mutation_p.Q15H|ZNF341_uc010geq.2_5'UTR|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGGACAATCAGACCGTTCTGG	0.542			NA											10	86					0.000673444	0.000717534	0.008291	1	0
DSN1	79980	broad.mit.edu	37	20	35386512	35386512	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:35386512C>A	uc010gfr.2	-	8	1076	c.703G>T	c.(703-705)GAG>TAG	p.E235*	DSN1_uc002xfz.2_Nonsense_Mutation_p.E235*|DSN1_uc002xfy.3_Nonsense_Mutation_p.E25*|DSN1_uc002xga.2_Nonsense_Mutation_p.E235*|DSN1_uc010zvs.1_Nonsense_Mutation_p.E128*|DSN1_uc002xgc.2_Nonsense_Mutation_p.E219*|DSN1_uc002xgb.2_Nonsense_Mutation_p.E219*	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,	235					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				TCTTTAGCCTCCTGCTGGTAG	0.338			NA											12	25					2.48551e-13	3.24854e-13	0.00499	1	0
R3HDML	140902	broad.mit.edu	37	20	42969876	42969877	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:42969876_42969877CC>AA	uc002xls.1	+	2	474_475	c.302_303CC>AA	c.(301-303)GCC>GAA	p.A101E		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	101						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GAAGCCTGGGCCACCCAGTGCA	0.589			NA											27	32					0	0	0.004672	0	0
ZNF335	63925	broad.mit.edu	37	20	44592118	44592118	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:44592118C>A	uc002xqw.2	-	9	1650	c.1527G>T	c.(1525-1527)TCG>TCT	p.S509S	ZNF335_uc010zxk.1_Silent_p.S354S	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	509	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GCACCTTGAGCGAGGACCAGC	0.627			NA											37	15					1.83081e-24	2.72461e-24	0.00361	1	0
ZNF335	63925	broad.mit.edu	37	20	44596595	44596595	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:44596595C>G	uc002xqw.2	-	5	715	c.592G>C	c.(592-594)GAT>CAT	p.D198H	ZNF335_uc010zxk.1_Missense_Mutation_p.D43H|ZNF335_uc002xqx.1_Missense_Mutation_p.D166H|ZNF335_uc002xqy.2_Missense_Mutation_p.D43H	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GTGGGGCCATCTGCCAGGGCC	0.657			NA											8	51					0	0	0.00308	0	0
SULF2	55959	broad.mit.edu	37	20	46365657	46365657	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:46365657G>T	uc002xto.2	-	3	535	c.205C>A	c.(205-207)CGC>AGC	p.R69S	SULF2_uc002xtr.2_Missense_Mutation_p.R69S|SULF2_uc002xtq.2_Missense_Mutation_p.R69S|SULF2_uc010ghv.1_Missense_Mutation_p.R69S	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	69					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TCCATGATGCGCCGGGTCTTG	0.637			NA											28	59					1.07637e-12	1.39059e-12	0.004878	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47569250	47569250	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:47569250G>T	uc002xtx.3	+	5	584	c.432G>T	c.(430-432)CTG>CTT	p.L144L		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	144					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGGCTCTTCTGACTGCAGTGA	0.453	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											9	74					2.80697e-09	3.38784e-09	0.000978	1	0
NFATC2	4773	broad.mit.edu	37	20	50140440	50140440	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr20:50140440C>A	uc002xwd.2	-	2	560	c.340G>T	c.(340-342)GAG>TAG	p.E114*	NFATC2_uc002xwc.2_Nonsense_Mutation_p.E114*|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Nonsense_Mutation_p.E94*|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Nonsense_Mutation_p.E94*	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	114	Calcineurin-binding.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGAGTGATCTCGATCCGAGGG	0.716			NA											18	49					5.26018e-13	6.83959e-13	0.001882	1	0
DNMT3L	29947	broad.mit.edu	37	21	45678524	45678524	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr21:45678524T>A	uc002zeg.1	-	6	882	c.398A>T	c.(397-399)AAG>ATG	p.K133M	DNMT3L_uc002zeh.1_Missense_Mutation_p.K133M	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	133	PHD-type; atypical.|ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		GGCGTGCACCTTCCCCGAGGT	0.642			NA											14	20					0	0	0.007413	0	0
C21orf29	54084	broad.mit.edu	37	21	45929228	45929228	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr21:45929228C>G	uc002zfe.1	-	10	1674	c.1608G>C	c.(1606-1608)GAG>GAC	p.E536D	C21orf29_uc010gpv.1_Missense_Mutation_p.E468D	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	536	EAR 5.				cell adhesion	extracellular region	structural molecule activity				0						GGAAGATCCTCTCCCCGATCT	0.473			NA											8	17					0	0	0.008291	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45970596	45970596	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr21:45970596G>C	uc002zfi.1	-	1	793	c.746C>G	c.(745-747)TCA>TGA	p.S249*	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	249						keratin filament				large_intestine(1)	1						CTTTTGGCCTGAGGAAAAGCT	0.677			NA											15	75					0	0	0.00499	0	0
DIP2A	23181	broad.mit.edu	37	21	47987424	47987424	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr21:47987424G>T	uc002zjo.2	+	38	4788	c.4605G>T	c.(4603-4605)GTG>GTT	p.V1535V	DIP2A_uc011afz.1_Silent_p.V1531V|DIP2A_uc002zjs.2_Silent_p.V215V|DIP2A_uc002zjt.2_RNA	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1535					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGGTCATCGTGGACCCAGGGG	0.632			NA											15	18					1.3612e-06	1.55017e-06	0.003163	1	0
UFD1L	7353	broad.mit.edu	37	22	19455527	19455527	+	Splice_Site	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:19455527C>T	uc002zpm.2	-	5	422	c.292_splice	c.e5-1	p.M98_splice	UFD1L_uc002zpo.2_Splice_Site_p.M98_splice|UFD1L_uc011agy.1_Splice_Site_p.M98_splice|UFD1L_uc002zpp.2_Splice_Site_p.M51_splice|UFD1L_uc010grq.2_Splice_Site_p.M51_splice	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A						skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					TCTGCATCATCTGAAAGGAAG	0.537			NA											4	35					0	0	0.009096	0	0
SLC7A4	6545	broad.mit.edu	37	22	21385387	21385388	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:21385387_21385388CC>AT	uc002zud.2	-	2	782_783	c.714_715GG>AT	c.(712-717)ATGGCC>ATATCC	p.238_239MA>IS	SLC7A4_uc002zue.2_Missense_Mutation_p.238_239MA>IS	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	238_239	Helical; (Potential).				cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GCAGTGCCGGCCATGACGCCGG	0.614			NA											8	16					0	0	0.004672	0	0
CCDC116	164592	broad.mit.edu	37	22	21991024	21991024	+	Missense_Mutation	SNP	G	G	C	rs143471938		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:21991024G>C	uc002zve.2	+	5	1600	c.1507G>C	c.(1507-1509)GAG>CAG	p.E503Q		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	503										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GCGTAAACTGGAGGAGTCCAA	0.632			NA											8	52					0	0	0.000978	0	0
MYO18B	84700	broad.mit.edu	37	22	26239702	26239702	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:26239702G>T	uc003abz.1	+	18	3459	c.3209G>T	c.(3208-3210)GGG>GTG	p.G1070V	MYO18B_uc003aca.1_Missense_Mutation_p.G951V|MYO18B_uc010guy.1_Missense_Mutation_p.G952V|MYO18B_uc010guz.1_Missense_Mutation_p.G951V|MYO18B_uc011aka.1_Missense_Mutation_p.G224V|MYO18B_uc011akb.1_Missense_Mutation_p.G583V	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1070	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CTGTTTCCAGGGTCCTCTGCC	0.572			NA											87	45					3.46703e-50	5.60614e-50	0.00361	1	0
MN1	4330	broad.mit.edu	37	22	28195093	28195093	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:28195093C>A	uc003adj.2	-	1	2394	c.1439G>T	c.(1438-1440)GGC>GTC	p.G480V		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	480							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						ATCCAGAGCGCCGTTGTGCAT	0.682			NA	T	ETV6	AML|meningioma								4	19					0.00909568	0.00941286	0.009096	1	0
AP1B1	162	broad.mit.edu	37	22	29726681	29726681	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:29726681C>T	uc003afj.2	-	20	2726	c.2542G>A	c.(2542-2544)GCC>ACC	p.A848T	AP1B1_uc003afi.2_Missense_Mutation_p.A841T|AP1B1_uc003afk.2_Missense_Mutation_p.A841T|AP1B1_uc003afl.2_Missense_Mutation_p.A821T|AP1B1_uc003afh.2_Missense_Mutation_p.A45T|AP1B1_uc011ako.1_Missense_Mutation_p.A401T	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	848					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						TTCCATGTGGCCAGGAACATC	0.612			NA											10	24					0	0	0.001368	0	0
SYN3	8224	broad.mit.edu	37	22	33402572	33402572	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:33402572G>C	uc003amx.2	-	1	235	c.76C>G	c.(76-78)CAA>GAA	p.Q26E	SYN3_uc003amy.2_Missense_Mutation_p.Q26E|SYN3_uc003amz.2_Missense_Mutation_p.Q26E	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	26	A.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						TCTGGGCGTTGCAGGTCCGTC	0.602			NA											50	84					0	0	0.00361	0	0
TRIOBP	11078	broad.mit.edu	37	22	38111839	38111839	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:38111839A>T	uc003atr.2	+	6	797	c.526A>T	c.(526-528)AGG>TGG	p.R176W	TRIOBP_uc003atu.2_Missense_Mutation_p.R4W|TRIOBP_uc003atq.1_Missense_Mutation_p.R176W|TRIOBP_uc003ats.1_Missense_Mutation_p.R4W	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	176					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GATGATCCCGAGGAGGCCTCG	0.622			NA											6	24					0	0	0.001984	0	0
WBP2NL	164684	broad.mit.edu	37	22	42422803	42422803	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:42422803G>A	uc011ape.1	+	7	564	c.548G>A	c.(547-549)GGA>GAA	p.G183E	WBP2NL_uc003bbt.2_Missense_Mutation_p.G183E|WBP2NL_uc011apk.1_Missense_Mutation_p.G55E|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	183	10 X 7 AA tandem repeat of Y-G-X-P-P-X-G.|Gly-rich.|2.				egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						GCAGGATATGGAGCCCCACCT	0.507			NA											4	135					0	0	0.009096	0	0
NAGA	4668	broad.mit.edu	37	22	42464492	42464492	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:42464492G>A	uc003bbx.2	-	3	240	c.103C>T	c.(103-105)CGC>TGC	p.R35C	NAGA_uc003bby.2_Missense_Mutation_p.R35C|NAGA_uc003bbw.3_Missense_Mutation_p.R35C	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	35					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						CAGCGGAAGCGTTCCCAGGCC	0.587			NA											10	106					0	0	0.008291	0	0
WNT7B	7477	broad.mit.edu	37	22	46345799	46345799	+	Splice_Site	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:46345799C>A	uc003bgo.2	-	2	672	c.298_splice	c.e2+1	p.G100_splice	WNT7B_uc010haa.2_Splice_Site_p.G104_splice	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,						activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GGCGCCCTTACCTACTCGGAG	0.637			NA											14	5					3.27435e-08	3.86864e-08	0.00245	1	0
IL17REL	400935	broad.mit.edu	37	22	50439231	50439231	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr22:50439231C>A	uc003bje.1	-	5	403	c.171G>T	c.(169-171)CAG>CAT	p.Q57H		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	57										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CCCACACGCTCTGACACTGCG	0.701			NA											3	20					0.00024832	0.00026826	0.009096	1	0
CNTN4	152330	broad.mit.edu	37	3	2924894	2924894	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:2924894G>A	uc003bpc.2	+	8	939	c.718G>A	c.(718-720)GGA>AGA	p.G240R	CNTN4_uc003bpb.1_Intron|CNTN4_uc003bpd.1_Missense_Mutation_p.G240R	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	240	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GACTGCAAAAGGAGCAACGGT	0.438			NA											17	12					0	0	0.008871	0	0
LRRN1	57633	broad.mit.edu	37	3	3886635	3886635	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:3886635C>A	uc003bpt.3	+	2	1071	c.310C>A	c.(310-312)CAA>AAA	p.Q104K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	104	LRR 2.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AGATTTCTCCCAAAACAACTT	0.438			NA											10	26					9.05144e-12	1.1546e-11	0.001855	1	0
LRRN1	57633	broad.mit.edu	37	3	3887802	3887802	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:3887802G>A	uc003bpt.3	+	2	2238	c.1477G>A	c.(1477-1479)GAC>AAC	p.D493N	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	493	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		ACAAATTGAAGACTCAGGAAG	0.438			NA											11	56					0	0	0.001368	0	0
PRRT3	285368	broad.mit.edu	37	3	9991120	9991120	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:9991120C>A	uc003bul.2	-	2	810	c.680G>T	c.(679-681)GGT>GTT	p.G227V	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA|PRRT3_uc003bum.2_Missense_Mutation_p.G227V	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	227	Extracellular (Potential).					integral to membrane					0						CTCAAACCCACCCTGTCCTTC	0.607			NA											27	28					4.87955e-14	6.46974e-14	0.005443	1	0
ATP2B2	491	broad.mit.edu	37	3	10400455	10400455	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:10400455C>A	uc003bvt.2	-	14	2495	c.2056G>T	c.(2056-2058)GAC>TAC	p.D686Y	ATP2B2_uc003bvv.2_Missense_Mutation_p.D641Y|ATP2B2_uc003bvw.2_Missense_Mutation_p.D641Y|ATP2B2_uc010hdo.2_Missense_Mutation_p.D391Y	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	686	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTGTCCCAGTCCGGCTCCGGG	0.632	Ovarian(125;1619 1709 15675 19819 38835)		NA											17	53					5.45024e-15	7.34218e-15	0.00333	1	0
ATP2B2	491	broad.mit.edu	37	3	10401723	10401723	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:10401723G>T	uc003bvt.2	-	13	2183	c.1744C>A	c.(1744-1746)CAG>AAG	p.Q582K	ATP2B2_uc003bvv.2_Missense_Mutation_p.Q537K|ATP2B2_uc003bvw.2_Missense_Mutation_p.Q537K|ATP2B2_uc010hdo.2_Missense_Mutation_p.Q287K	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	582	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCGTAGTCCTGCTTCAGGTCC	0.607	Ovarian(125;1619 1709 15675 19819 38835)		NA											33	37					5.71845e-15	7.69322e-15	0.005524	1	0
NUP210	23225	broad.mit.edu	37	3	13441297	13441297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:13441297G>A	uc003bxv.1	-	2	315	c.232C>T	c.(232-234)CAG>TAG	p.Q78*		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	78	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					ACTGCCTTCTGGGAGCACTGC	0.632			NA											46	53					0	0	0.00361	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15123931	15123931	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:15123931C>T	uc003bzm.1	-	9	1397	c.783G>A	c.(781-783)AAG>AAA	p.K261K	ZFYVE20_uc010hek.1_Silent_p.K261K|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	261	Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GCTGCTCTCTCTTGAGCAGCG	0.542			NA											11	55					0	0	0.001855	0	0
KAT2B	8850	broad.mit.edu	37	3	20161127	20161127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:20161127C>A	uc003cbq.2	+	8	1634	c.1188C>A	c.(1186-1188)TAC>TAA	p.Y396*		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	396					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAATTTCATACAATTCAACCT	0.488			NA											9	51					7.48243e-07	8.56955e-07	0.006214	1	0
TGFBR2	7048	broad.mit.edu	37	3	30733001	30733001	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:30733001C>T	uc003ceo.2	+	7	1996	c.1614C>T	c.(1612-1614)TTC>TTT	p.F538F	TGFBR2_uc003cen.2_Silent_p.F563F	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	538	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CAGAACGCTTCAGTGAGCTGG	0.587			NA											10	84					0	0	0.000978	0	0
CRTAP	10491	broad.mit.edu	37	3	33174160	33174160	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:33174160G>T	uc003cfl.3	+	5	1156	c.1036G>T	c.(1036-1038)GGC>TGC	p.G346C	CRTAP_uc010hfz.2_Missense_Mutation_p.G303C|CRTAP_uc003cfm.2_Missense_Mutation_p.G167C|CRTAP_uc003cfn.2_Missense_Mutation_p.G167C	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	346						proteinaceous extracellular matrix	binding				0						GGACACTTGGGGCCTCTCGGA	0.527			NA											22	83					1.1804e-14	1.57751e-14	0.003954	1	0
TRANK1	9881	broad.mit.edu	37	3	36876324	36876324	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:36876324C>A	uc003cgj.2	-	11	4112	c.3810G>T	c.(3808-3810)CAG>CAT	p.Q1270H		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1820	TPR 4.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GATCAAATTCCTGAATCTGCT	0.398			NA											10	15					0.000978159	0.00104	0.000978	1	0
SCN10A	6336	broad.mit.edu	37	3	38835286	38835286	+	Silent	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:38835286T>A	uc003ciq.2	-	1	216	c.216A>T	c.(214-216)GCA>GCT	p.A72A		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	72					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CGATCAGTTCTGCTGGGAGCT	0.552			NA											65	68					0	0	0.00361	0	0
TRAK1	22906	broad.mit.edu	37	3	42133018	42133018	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:42133018C>G	uc003cky.2	+	1	273	c.57C>G	c.(55-57)CTC>CTG	p.L19L	TRAK1_uc011azh.1_Silent_p.L19L|TRAK1_uc011azi.1_Silent_p.L19L	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	19					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TGCCAGGACTCTGCCACGGCA	0.517	GBM(44;195 884 22595 31865 41850)		NA											6	33					0	0	0.00308	0	0
KBTBD5	131377	broad.mit.edu	37	3	42727389	42727389	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:42727389G>C	uc003clv.1	+	1	379	c.279G>C	c.(277-279)GAG>GAC	p.E93D		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	93	BTB.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ACACATCAGAGATCGCGCTGG	0.642			NA											3	47					0	0	0.009096	0	0
PTH1R	5745	broad.mit.edu	37	3	46943287	46943287	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:46943287G>A	uc003cqm.2	+	13	1351	c.1148G>A	c.(1147-1149)CGG>CAG	p.R383Q	PTH1R_uc003cqn.2_Missense_Mutation_p.R383Q	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	383	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						AATATCGTCCGGGTGCTCGCC	0.662			NA							Ollier_disease_/_Maffucsyndrome				31	50					0	0	0.00623	0	0
KLHL18	23276	broad.mit.edu	37	3	47371576	47371577	+	Missense_Mutation	DNP	GC	GC	TG			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:47371576_47371577GC>TG	uc003crd.2	+	4	663_664	c.537_538GC>TG	c.(535-540)CTGCCC>CTTGCC	p.P180A	KLHL18_uc003crc.2_Missense_Mutation_p.P180A|KLHL18_uc011bav.1_Missense_Mutation_p.P68A|KLHL18_uc010hjq.1_Missense_Mutation_p.P31A	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	180	BACK.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		TCCTGGCCCTGCCCTTGGAAGA	0.535			NA											29	35					0	0	0.004672	0	0
CELSR3	1951	broad.mit.edu	37	3	48693266	48693266	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:48693266C>G	uc003cul.2	-	4	4925	c.4644G>C	c.(4642-4644)CAG>CAC	p.Q1548H	CELSR3_uc003cuf.1_Missense_Mutation_p.Q1618H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1548	Extracellular (Potential).|Laminin G-like 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCAGCCCGCTCTGCTGCACTG	0.652			NA											9	33					0	0	0.004482	0	0
QARS	5859	broad.mit.edu	37	3	49138787	49138787	+	Splice_Site	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:49138787C>T	uc003cvx.2	-	10	881	c.876_splice	c.e10+1	p.K292_splice	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Splice_Site_p.K147_splice|QARS_uc003cvy.2_Splice_Site_p.K147_splice|QARS_uc011bce.1_Splice_Site_p.K281_splice|QARS_uc011bcf.1_Splice_Site_p.V264_splice	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase						glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CACATGCTTACCTTGGCATAG	0.493			NA											27	37					0	0	0.002096	0	0
RNF123	63891	broad.mit.edu	37	3	49758500	49758500	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:49758500C>T	uc003cxh.2	+	38	3872	c.3786C>T	c.(3784-3786)ATC>ATT	p.I1262I	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1262	RING-type.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CCCACCCCATCTCTGCTGTGT	0.607			NA											16	85					0	0	0.002299	0	0
SLC38A3	10991	broad.mit.edu	37	3	50255703	50255703	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:50255703C>G	uc003cyn.3	+	12	1078	c.937C>G	c.(937-939)CCC>GCC	p.P313A	SLC38A3_uc011bdl.1_Missense_Mutation_p.P288A|SLC38A3_uc011bdm.1_Missense_Mutation_p.P244A	NM_006841	NP_006832	Q99624	S38A3_HUMAN	solute carrier family 38, member 3	313					cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	TCCCCACAGCCCCTCCAAGAA	0.552			NA											28	55					0	0	0.007291	0	0
ITIH1	3697	broad.mit.edu	37	3	52818319	52818319	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:52818319G>T	uc003dfs.2	+	11	1257	c.1233G>T	c.(1231-1233)ACG>ACT	p.T411T	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.T12T|ITIH1_uc010hmo.1_5'UTR	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	411	Hyaluronan-binding.|VWFA.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CAGGGGTGACGGACCGTTCCC	0.617			NA											6	13					1.26484e-09	1.54882e-09	0.00308	1	0
PDZRN3	23024	broad.mit.edu	37	3	73440201	73440201	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:73440201C>G	uc003dpl.1	-	6	1417	c.1321G>C	c.(1321-1323)GAT>CAT	p.D441H	PDZRN3_uc011bgh.1_Missense_Mutation_p.D98H|PDZRN3_uc010hoe.1_Missense_Mutation_p.D139H|PDZRN3_uc011bgf.1_Missense_Mutation_p.D158H|PDZRN3_uc011bgg.1_Missense_Mutation_p.D161H	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	441	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCGTCTTCATCGTCCGTCCGG	0.438			NA											31	158					0	0	0.005524	0	0
VGLL3	389136	broad.mit.edu	37	3	87027684	87027684	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:87027684A>T	uc003dqn.2	-	2	759	c.395T>A	c.(394-396)CTA>CAA	p.L132Q		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ACCTCGCCATAGGGGGGTTAG	0.512			NA											53	75					0	0	0.00361	0	0
OR5H1	26341	broad.mit.edu	37	3	97852446	97852446	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:97852446C>G	uc011bgt.1	+	1	905	c.905C>G	c.(904-906)ACA>AGA	p.T302R		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GTTTCATTCACAAAAATGTTA	0.313			NA											3	48					0	0	0.009096	0	0
GPR15	2838	broad.mit.edu	37	3	98251467	98251467	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:98251467T>C	uc011bgy.1	+	1	590	c.590T>C	c.(589-591)CTG>CCG	p.L197P		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	197	Helical; Name=5; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		ATATGGTCCCTGGTGGCCTTA	0.468			NA											7	99					0	0	0.001984	0	0
C3orf26	84319	broad.mit.edu	37	3	99891180	99891180	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:99891180G>A	uc003dtl.2	+	8	743	c.600G>A	c.(598-600)TTG>TTA	p.L200L		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	200							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						AGGTAAAGTTGCTGGAGAAGC	0.433			NA											6	58					0	0	0.001984	0	0
IMPG2	50939	broad.mit.edu	37	3	101023064	101023064	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:101023064C>T	uc003duq.1	-	3	630	c.427G>A	c.(427-429)GAT>AAT	p.D143N	IMPG2_uc011bhe.1_Missense_Mutation_p.D6N	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	143	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GTGACTCCATCCTCACACAAA	0.413			NA											83	39					0	0	0.00361	0	0
TRAT1	50852	broad.mit.edu	37	3	108572674	108572674	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:108572674C>G	uc003dxi.1	+	6	655	c.511C>G	c.(511-513)CCC>GCC	p.P171A	TRAT1_uc010hpx.1_Missense_Mutation_p.P134A	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	171	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						TCATGATGATCCCATCAGACT	0.433			NA											44	122					0	0	0.00361	0	0
DPPA2	151871	broad.mit.edu	37	3	109028078	109028078	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:109028078T>A	uc003dxo.2	-	4	528	c.281A>T	c.(280-282)AAG>ATG	p.K94M		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	94	SAP.					nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CCGACACACCTTATTAATGGG	0.448			NA											115	158					0	0	0.00361	0	0
ZBED2	79413	broad.mit.edu	37	3	111312970	111312970	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:111312970C>G	uc003dxy.2	-	2	964	c.79G>C	c.(79-81)GAG>CAG	p.E27Q	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	27							DNA binding|metal ion binding			skin(1)	1						TCACTAATCTCTTCCTCCTCC	0.517			NA											52	55					0	0	0.00361	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432915	111432915	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:111432915C>A	uc003dya.2	+	3	1392	c.806C>A	c.(805-807)CCC>CAC	p.P269H	PLCXD2_uc003dyb.2_Missense_Mutation_p.P269H|PLCXD2_uc003dxz.2_Missense_Mutation_p.P269H	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	269					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ATCCTCACCCCCAGAGTGAAG	0.537			NA											28	65					5.09552e-08	5.97835e-08	0.002096	1	0
HGD	3081	broad.mit.edu	37	3	120393758	120393758	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:120393758T>C	uc003edw.2	-	3	536	c.166A>G	c.(166-168)AAT>GAT	p.N56D		NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	56					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		CTTCTCTTATTGGTGCTCCGT	0.498			NA											8	193					0	0	0.006214	0	0
GATA2	2624	broad.mit.edu	37	3	128204775	128204775	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:128204775C>T	uc003ekm.3	-	4	1101	c.666G>A	c.(664-666)AAG>AAA	p.K222K	GATA2_uc003ekn.3_Silent_p.K222K|GATA2_uc003eko.2_Silent_p.K222K	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	222					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		CACTTTCCATCTTCATGCTCT	0.642			NA	Mis		AML(CML blast transformation)								15	74					0	0	0.00499	0	0
CCDC48	79825	broad.mit.edu	37	3	128758633	128758633	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:128758633C>A	uc011bkt.1	+	8	1739	c.1739C>A	c.(1738-1740)CCC>CAC	p.P580H		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	580											0						CGGAGACAGCCCTCGGCACCA	0.667			NA											71	33					1.15098e-32	1.78119e-32	0.00361	1	0
SLCO2A1	6578	broad.mit.edu	37	3	133666128	133666128	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:133666128G>A	uc003eqa.3	-	9	1541	c.1267C>T	c.(1267-1269)CCA>TCA	p.P423S	SLCO2A1_uc003eqb.3_Missense_Mutation_p.P347S|SLCO2A1_uc011blv.1_Missense_Mutation_p.P242S	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	423	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GCCACAGTTGGGGTGGAGCAT	0.483			NA											15	66					0	0	0.001882	0	0
CLSTN2	64084	broad.mit.edu	37	3	140178588	140178588	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:140178588T>A	uc003etn.2	+	7	1389	c.1199T>A	c.(1198-1200)ATC>AAC	p.I400N	CLSTN2_uc003etm.2_Missense_Mutation_p.I400N	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	400	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AAGGAAACCATCCTCTGCAAC	0.577	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			12	100					0	0	0.000978	0	0
CLSTN2	64084	broad.mit.edu	37	3	140281710	140281711	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:140281710_140281711GG>TT	uc003etn.2	+	14	2460_2461	c.2270_2271GG>TT	c.(2269-2271)TGG>TTT	p.W757F		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	757	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TACCGCAACTGGCGTCCGGCTT	0.559	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			14	48					0	0	0.004672	0	0
RASA2	5922	broad.mit.edu	37	3	141328870	141328870	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:141328870T>C	uc003etz.1	+	23	2481	c.2481T>C	c.(2479-2481)TAT>TAC	p.Y827Y	RASA2_uc010huq.1_Silent_p.Y831Y|RASA2_uc003eua.1_Silent_p.Y828Y|uc003eub.2_5'Flank	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	827					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						ATGAAAAATATAGGAAGAAAA	0.323			NA											50	16					0	0	0.00361	0	0
PLSCR1	5359	broad.mit.edu	37	3	146239458	146239458	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:146239458C>A	uc003evx.3	-	7	999	c.611G>T	c.(610-612)GGT>GTT	p.G204V	PLSCR1_uc003evy.3_Missense_Mutation_p.G197V|PLSCR1_uc011bnn.1_Missense_Mutation_p.G123V|PLSCR1_uc003evz.3_Intron	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	204	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						AATAACATAACCTATTGGTAC	0.353			NA											18	32					4.35082e-09	5.23863e-09	0.010504	1	0
RSRC1	51319	broad.mit.edu	37	3	158072675	158072675	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:158072675A>G	uc003fbt.2	+	6	672	c.561A>G	c.(559-561)CTA>CTG	p.L187L	RSRC1_uc011bou.1_Silent_p.L129L|RSRC1_uc003fbu.1_Silent_p.L187L|RSRC1_uc003fbv.2_Silent_p.L129L	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	187	Potential.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			AAGCCAGACTACAGCTGGTTC	0.363			NA											7	10					0	0	0.008291	0	0
SMC4	10051	broad.mit.edu	37	3	160150941	160150941	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:160150941G>A	uc003fdh.2	+	23	3771	c.3658G>A	c.(3658-3660)GAG>AAG	p.E1220K	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.E1195K|SMC4_uc003fdj.2_Missense_Mutation_p.E1220K|SMC4_uc010hwd.2_Missense_Mutation_p.E1162K|SMC4_uc003fdl.2_Missense_Mutation_p.E923K	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1220	Ala/Asp-rich (DA-box).				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTTCATGGATGAGATTGATGC	0.368			NA											22	133					0	0	0.00632	0	0
NCEH1	57552	broad.mit.edu	37	3	172365893	172365893	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:172365893G>T	uc011bpx.1	-	2	384	c.246C>A	c.(244-246)ATC>ATA	p.I82I	NCEH1_uc003fig.2_Silent_p.I82I|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	50	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						CCAGGTAGTGGATCAGGTTAC	0.522			NA											13	65					2.48551e-13	3.24854e-13	0.00499	1	0
ZNF639	51193	broad.mit.edu	37	3	179051405	179051405	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:179051405A>C	uc003fjq.1	+	6	996	c.653A>C	c.(652-654)GAC>GCC	p.D218A	ZNF639_uc003fjr.1_Missense_Mutation_p.D218A	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	218	C2H2-type 1.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TATTTTTCTGACTTAAAGCAG	0.378			NA											57	18					0	0	0.00361	0	0
MASP1	5648	broad.mit.edu	37	3	186969535	186969535	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:186969535C>T	uc003frh.1	-	7	1230	c.898G>A	c.(898-900)GAG>AAG	p.E300K	MASP1_uc003fri.2_Missense_Mutation_p.E300K|MASP1_uc003frj.2_Missense_Mutation_p.E269K|MASP1_uc003frk.1_Missense_Mutation_p.E300K|MASP1_uc011bse.1_Missense_Mutation_p.E274K	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	300	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TCTGGGCACTCATTTCCTGGT	0.493			NA											8	65					0	0	0.006214	0	0
LRRC33	375387	broad.mit.edu	37	3	196386878	196386878	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr3:196386878G>T	uc003fwv.2	+	3	468	c.364G>T	c.(364-366)GAA>TAA	p.E122*		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	122	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		AGAGAACTACGAAGAGACGGC	0.667			NA											12	20					1.61879e-10	2.01649e-10	0.001368	1	0
SPON2	10417	broad.mit.edu	37	4	1161317	1161317	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:1161317C>T	uc003gcn.3	-	5	966	c.939G>A	c.(937-939)GGG>GGA	p.G313G	SPON2_uc003gco.3_Silent_p.G313G|SPON2_uc010ibr.2_Silent_p.G313G|SPON2_uc003gcm.1_3'UTR	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	313	TSP type-1.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		GGCAGGGGCTCCCGTTGTTGG	0.687			NA									OREG0016030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	131					0	0	0.00245	0	0
HGFAC	3083	broad.mit.edu	37	4	3447974	3447975	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:3447974_3447975GG>AT	uc003ghc.2	+	10	1311_1312	c.1308_1309GG>AT	c.(1306-1311)CTGGTC>CTATTC	p.V437F	HGFAC_uc010icw.2_Missense_Mutation_p.V444F	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	437	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCGGGAGCCTGGTCCACACCTG	0.698			NA											4	14					0	0	0.004672	0	0
MAN2B2	23324	broad.mit.edu	37	4	6610904	6610904	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:6610904G>A	uc003gjf.1	+	12	1921	c.1885G>A	c.(1885-1887)GGC>AGC	p.G629S	MAN2B2_uc003gje.1_Missense_Mutation_p.G629S|MAN2B2_uc011bwf.1_Missense_Mutation_p.G578S	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	629					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						TGTGAAACAGGGCCCCATTTC	0.567			NA											12	58					0	0	0.001855	0	0
TBC1D14	57533	broad.mit.edu	37	4	7002883	7002883	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:7002883G>C	uc011bwg.1	+	7	1254	c.1175G>C	c.(1174-1176)AGA>ACA	p.R392T	TBC1D14_uc003gjs.3_Missense_Mutation_p.R392T|TBC1D14_uc010idh.2_Missense_Mutation_p.R112T|TBC1D14_uc011bwh.1_Missense_Mutation_p.R5T|TBC1D14_uc003gju.3_5'UTR	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	392						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						TGGTGCTCTAGAAAAGTTCGA	0.388			NA											5	63					0	0	0.001168	0	0
ACOX3	8310	broad.mit.edu	37	4	8417721	8417721	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:8417721G>A	uc010idk.2	-	3	295	c.150C>T	c.(148-150)ACC>ACT	p.T50T	ACOX3_uc003glc.3_Silent_p.T50T|ACOX3_uc003gld.3_Silent_p.T50T|ACOX3_uc003gle.1_5'UTR	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	50					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						CTGAGAAGATGGTTTTCTGGA	0.493			NA											22	31					0	0	0.003954	0	0
CCKAR	886	broad.mit.edu	37	4	26490882	26490882	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:26490882C>T	uc003gse.1	-	2	490	c.337G>A	c.(337-339)GTT>ATT	p.V113I		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	113	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GTCTTGCAAACGGCGCTCCCG	0.562			NA											41	111					0	0	0.007835	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016288	38016288	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:38016288G>T	uc003gtb.2	+	3	919	c.576G>T	c.(574-576)CTG>CTT	p.L192L	TBC1D1_uc011byd.1_Silent_p.L192L|TBC1D1_uc010ifd.2_Intron|TBC1D1_uc011byf.1_Silent_p.L63L	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	192						nucleus	Rab GTPase activator activity			ovary(1)	1						CGCCGGCCCTGATCGACGAGT	0.672			NA											57	97					2.50483e-33	3.88826e-33	0.00361	1	0
GABRG1	2565	broad.mit.edu	37	4	46060534	46060534	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:46060534C>T	uc003gxb.2	-	6	883	c.731G>A	c.(730-732)CGG>CAG	p.R244Q		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	244	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AGTTGAGTTCCGTAACCCTAC	0.333			NA											32	90					0	0	0.007835	0	0
CORIN	10699	broad.mit.edu	37	4	47628443	47628443	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:47628443A>G	uc003gxm.2	-	17	2387	c.2294T>C	c.(2293-2295)TTA>TCA	p.L765S	CORIN_uc011bzf.1_Missense_Mutation_p.L626S|CORIN_uc011bzg.1_Missense_Mutation_p.L698S	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	765	Extracellular (Potential).|SRCR.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						AAGTTCATGTAAAGTGGTCCC	0.428			NA											20	356					0	0	0.010504	0	0
NIPAL1	152519	broad.mit.edu	37	4	48038107	48038107	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:48038107A>T	uc003gxw.2	+	6	1217	c.1151A>T	c.(1150-1152)AAT>ATT	p.N384I		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	384	Cytoplasmic (Potential).					integral to membrane					0						AATGAAAACAATTATGTTTTA	0.378			NA											32	105					0	0	0.004878	0	0
RASL11B	65997	broad.mit.edu	37	4	53730701	53730701	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:53730701C>G	uc003gzt.2	+	3	436	c.256C>G	c.(256-258)CAA>GAA	p.Q86E		NM_023940	NP_076429	Q9BPW5	RSLBB_HUMAN	RAS-like family 11 member B	86	Small GTPase-like.				small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0302)			TCTTCAGGTTCAAGACACTCC	0.428			NA											32	170					0	0	0.004289	0	0
PDGFRA	5156	broad.mit.edu	37	4	55133802	55133802	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:55133802G>T	uc003han.3	+	7	1346	c.1015G>T	c.(1015-1017)GTG>TTG	p.V339L	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.V233L|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	339	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGTTGTAGAGGTGCGGGCCTA	0.448	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			29	60					2.70662e-09	3.28638e-09	0.009535	1	0
EPHA5	2044	broad.mit.edu	37	4	66218759	66218759	+	Splice_Site	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:66218759C>T	uc003hcy.2	-	13	2491	c.2298_splice	c.e13+1	p.K766_splice	EPHA5_uc003hcx.2_Splice_Site_p.K698_splice|EPHA5_uc003hcz.2_Splice_Site_p.K744_splice|EPHA5_uc011cah.1_Splice_Site_p.K767_splice|EPHA5_uc011cai.1_Splice_Site_p.K745_splice|EPHA5_uc003hda.2_Splice_Site_p.K767_splice	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor						cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCCAATCCTACCTTCAAAAAT	0.368			NA								TSP Lung(17;0.13)			50	22					0	0	0.00361	0	0
Unknown	0	broad.mit.edu	37	4	69337249	69337249	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:69337249C>A	uc003hdz.3	+	5	462	c.398C>A	c.(397-399)ACT>AAT	p.T133N		NM_014058	NP_054777			transmembrane protease, serine 11E												NA						GATCCTGAAACTGTAGATAAA	0.358			NA											68	197					9.12251e-31	1.39888e-30	0.00361	1	0
SULT1E1	6783	broad.mit.edu	37	4	70720024	70720024	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:70720024G>T	uc003heo.2	-	4	393	c.280C>A	c.(280-282)CAA>AAA	p.Q94K	SULT1E1_uc010ihv.1_Missense_Mutation_p.Q94K	NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	94					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						TCATCTAATTGTTTTACTCCT	0.303			NA											12	35					2.27111e-07	2.61891e-07	0.001368	1	0
ODAM	54959	broad.mit.edu	37	4	71063851	71063851	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:71063851C>T	uc003hfc.2	+	4	369	c.352C>T	c.(352-354)CAG>TAG	p.Q118*		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	118	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						AACACCGCCTCAGACACAACC	0.488			NA											18	126					0	0	0.007413	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149349	73149349	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:73149349C>A	uc003hgk.1	-	22	3159	c.3122G>T	c.(3121-3123)GGT>GTT	p.G1041V		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1041	PLAC.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTGTTATAACCTGGTATGGA	0.418	NSCLC(168;1941 2048 2918 13048 43078)		NA											13	150					2.48551e-13	3.24854e-13	0.00499	1	0
SHROOM3	57619	broad.mit.edu	37	4	77357309	77357309	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:77357309G>A	uc011cbx.1	+	1	1057	c.104G>A	c.(103-105)GGA>GAA	p.G35E		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	35	PDZ.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CTGGAGGGAGGAGCTCCCTGG	0.458			NA											34	263					0	0	0.00874	0	0
MRPL1	65008	broad.mit.edu	37	4	78830457	78830457	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:78830457A>G	uc003hku.2	+	7	906	c.708A>G	c.(706-708)TTA>TTG	p.L236L	MRPL1_uc010iji.1_Silent_p.L159L	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	236							RNA binding				0						TGCTTGAATTATTTAAAAATG	0.303			NA											40	98					0	0	0.00361	0	0
SEC31A	22872	broad.mit.edu	37	4	83748590	83748590	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:83748590T>C	uc003hnf.2	-	24	3387	c.3223A>G	c.(3223-3225)ATG>GTG	p.M1075V	SEC31A_uc003hnd.2_Missense_Mutation_p.M244V|SEC31A_uc003hne.2_Missense_Mutation_p.M824V|SEC31A_uc011ccl.1_Missense_Mutation_p.M1021V|SEC31A_uc003hnl.2_Missense_Mutation_p.M922V|SEC31A_uc003hng.2_Missense_Mutation_p.M1060V|SEC31A_uc003hnh.2_Missense_Mutation_p.M1075V|SEC31A_uc003hni.2_Missense_Mutation_p.M961V|SEC31A_uc003hnj.2_Missense_Mutation_p.M1036V|SEC31A_uc011ccm.1_Missense_Mutation_p.M1055V|SEC31A_uc011ccn.1_Missense_Mutation_p.M1060V|SEC31A_uc003hnk.2_Missense_Mutation_p.M1036V|SEC31A_uc003hnm.2_Missense_Mutation_p.M1075V	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1075	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GATGGTGGCATGCCTGTTTGA	0.498			NA											92	29					0	0	0.00361	0	0
DMP1	1758	broad.mit.edu	37	4	88580622	88580622	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:88580622G>C	uc003hqv.2	+	5	279	c.175G>C	c.(175-177)GAG>CAG	p.E59Q	DMP1_uc003hqw.2_Intron	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	59					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AGTTAGCTCAGAGGAACAGGT	0.348			NA											8	85					0	0	0.008291	0	0
SPP1	6696	broad.mit.edu	37	4	88902898	88902898	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:88902898T>C	uc003hra.2	+	6	653	c.488T>C	c.(487-489)GTG>GCG	p.V163A	SPP1_uc003hrb.2_Missense_Mutation_p.V136A|SPP1_uc003hrc.2_Missense_Mutation_p.V149A|SPP1_uc011cde.1_Missense_Mutation_p.V176A|SPP1_uc003hrd.2_Missense_Mutation_p.V122A	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	163					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		GGTGATAGTGTGGTTTATGGA	0.473			NA											16	86					0	0	0.007413	0	0
MMRN1	22915	broad.mit.edu	37	4	90856810	90856810	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:90856810G>T	uc003hst.2	+	6	2050	c.1979G>T	c.(1978-1980)AGA>ATA	p.R660I	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.R402I	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	660					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GCATCACTCAGACAGACAATG	0.358			NA											47	18					6.08268e-21	8.76775e-21	0.00361	1	0
NDST4	64579	broad.mit.edu	37	4	115997976	115997976	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:115997976T>G	uc003ibu.2	-	2	896	c.217A>C	c.(217-219)ACA>CCA	p.T73P	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	73	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTTTTGGATGTGTCAATAGGT	0.418			NA											49	25					0	0	0.00361	0	0
KIAA1109	84162	broad.mit.edu	37	4	123164214	123164214	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:123164214C>G	uc003ieh.2	+	28	4778	c.4733C>G	c.(4732-4734)TCA>TGA	p.S1578*	KIAA1109_uc003iek.2_Nonsense_Mutation_p.S197*	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1578					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTTTCAGGATCAACTTCAAAG	0.303			NA											7	137					0	0	0.006214	0	0
FAT4	79633	broad.mit.edu	37	4	126241663	126241663	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:126241663G>T	uc003ifj.3	+	1	4097	c.4097G>T	c.(4096-4098)AGC>ATC	p.S1366I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1366	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTTAGCATTAGCCCAAACACT	0.383			NA											62	107					5.44642e-36	8.54656e-36	0.00361	1	0
TTC29	83894	broad.mit.edu	37	4	147824710	147824710	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:147824710A>G	uc003ikw.3	-	6	799	c.572T>C	c.(571-573)CTC>CCC	p.L191P	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.L217P|TTC29_uc010ipd.1_Missense_Mutation_p.L191P	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	191	TPR 1.						binding				0	all_hematologic(180;0.151)					TTCCTCGTAGAGAAGACCCAT	0.458			NA											7	20					0	0	0.004482	0	0
RBM46	166863	broad.mit.edu	37	4	155720326	155720326	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:155720326G>T	uc003ioo.2	+	4	1185	c.1012G>T	c.(1012-1014)GAG>TAG	p.E338*	RBM46_uc011cim.1_Nonsense_Mutation_p.E338*|RBM46_uc003iop.1_Nonsense_Mutation_p.E338*	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	338							nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				TAACAAAGAAGAGAGCCACCC	0.428			NA											6	53					2.17888e-05	2.40535e-05	0.006214	1	0
PPID	5481	broad.mit.edu	37	4	159644357	159644357	+	Silent	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:159644357T>A	uc003iqc.2	-	1	196	c.84A>T	c.(82-84)CGA>CGT	p.R28R		NM_005038	NP_005029	Q08752	PPID_HUMAN	peptidylprolyl isomerase D	28	PPIase cyclophilin-type.				protein folding	cytoplasm|intermediate filament cytoskeleton	cyclosporin A binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0159)		TCCGCTCACCTCGCTCCCCTC	0.647			NA											31	9					0	0	0.003271	0	0
FSTL5	56884	broad.mit.edu	37	4	162402214	162402214	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:162402214G>T	uc003iqh.2	-	13	2002	c.1566C>A	c.(1564-1566)GAC>GAA	p.D522E	FSTL5_uc003iqi.2_Missense_Mutation_p.D521E|FSTL5_uc010iqv.2_Missense_Mutation_p.D512E	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	522						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TAAGGACTCTGTCCAAAGTTG	0.343			NA											39	93					6.48837e-15	8.7058e-15	0.002522	1	0
C4orf39	152756	broad.mit.edu	37	4	165878576	165878576	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:165878576T>C	uc003iqx.1	+	1	477	c.402T>C	c.(400-402)CCT>CCC	p.P134P	TRIM61_uc003iqw.2_Intron	NM_153027	NP_694572	Q96MZ4	CD039_HUMAN	hypothetical protein LOC152756	134											0	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.146)		GGTCCCAGCCTCTTTTTGTGA	0.572			NA											3	77					0	0	0.001168	0	0
DDX60	55601	broad.mit.edu	37	4	169146827	169146828	+	Splice_Site	DNP	CC	CC	AT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:169146827_169146828CC>AT	uc003irp.2	-	34	4826	c.4534_splice	c.e34-1	p.V1512_splice	DDX60_uc003iro.2_5'UTR	NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TCAAGGAACACCTAGAAGCCGA	0.332			NA											30	15					0	0	0.004672	0	0
HAND2	9464	broad.mit.edu	37	4	174449985	174449985	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:174449985C>A	uc003ith.1	-	1	1394	c.456G>T	c.(454-456)ATG>ATT	p.M152I	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Nonsense_Mutation_p.G118*|HAND2_uc010ire.1_Missense_Mutation_p.M152I	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	152	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CCAGCAGGTCCATGAGGTAGG	0.592			NA											33	71					1.07637e-12	1.39059e-12	0.004878	1	0
WDR17	116966	broad.mit.edu	37	4	177071727	177071727	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:177071727C>A	uc003iuj.2	+	17	2515	c.2359C>A	c.(2359-2361)CTG>ATG	p.L787M	WDR17_uc003iuk.2_Missense_Mutation_p.L763M|WDR17_uc003ium.3_Missense_Mutation_p.L763M|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.L6M	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	787										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTTGAAACATCTGATTAAATT	0.294			NA											10	55					5.16669e-11	6.48406e-11	0.000978	1	0
ASB5	140458	broad.mit.edu	37	4	177190244	177190244	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:177190244C>T	uc003iuq.1	-	1	32	c.16G>A	c.(16-18)GAA>AAA	p.E6K		NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	6					intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GGCCGATTTTCTTCTAACACC	0.453			NA											10	75					0	0	0.000978	0	0
ENPP6	133121	broad.mit.edu	37	4	185018460	185018460	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:185018460C>A	uc003iwc.2	-	7	1197	c.1055G>T	c.(1054-1056)GGA>GTA	p.G352V		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	352	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GCCGTGCCATCCACGCTGCCA	0.567			NA											38	72					9.22156e-22	1.34459e-21	0.00361	1	0
HELT	391723	broad.mit.edu	37	4	185941818	185941818	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:185941818C>T	uc011ckq.1	+	4	876	c.876C>T	c.(874-876)CCC>CCT	p.P292P	HELT_uc011cko.1_Silent_p.P207P|HELT_uc003ixa.3_Silent_p.P206P|HELT_uc011ckp.1_Silent_p.P150P	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	292	Pro-rich.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AGCACAGCCCCTTCCTGACAC	0.736			NA											17	41					0	0	0.007413	0	0
FAM149A	25854	broad.mit.edu	37	4	187078867	187078867	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:187078867G>T	uc003iyt.3	+	8	1302	c.723G>T	c.(721-723)CCG>CCT	p.P241P	FAM149A_uc011cla.1_Silent_p.P241P|FAM149A_uc010isj.2_Silent_p.P241P|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Silent_p.P241P|FAM149A_uc010isl.2_Silent_p.P241P|FAM149A_uc011clb.1_Silent_p.P241P	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	532										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		GTCTGAACCCGCCCCAGGTCG	0.592			NA											57	21					2.23399e-28	3.40499e-28	0.00361	1	0
TRIML1	339976	broad.mit.edu	37	4	189063430	189063430	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:189063430G>A	uc003izm.1	+	3	644	c.529G>A	c.(529-531)GTT>ATT	p.V177I	TRIML1_uc003izn.1_5'Flank	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	177					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TTGTAAACAGGTTGTTGTGTC	0.343	Melanoma(31;213 1036 16579 23968 32372)		NA											35	13					0	0	0.00623	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163505	163505	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:163505C>T	uc003jak.2	+	11	2300	c.2250C>T	c.(2248-2250)GTC>GTT	p.V750V		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	750					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		ATACTAGTGTCTTCAGCAAGG	0.567			NA											74	86					0	0	0.00361	0	0
ZDHHC11	79844	broad.mit.edu	37	5	850634	850634	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:850634G>A	uc011cma.1	-	1	468	c.84C>T	c.(82-84)ATC>ATT	p.I28I	ZDHHC11_uc003jbj.2_5'Flank	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	28						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			TCACTCTGGAGATGCGGGGCG	0.587			NA											16	115					0	0	0.007413	0	0
IRX1	79192	broad.mit.edu	37	5	3599344	3599344	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:3599344G>C	uc003jde.2	+	2	334	c.282G>C	c.(280-282)TCG>TCC	p.S94S		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	94						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TTCAGGGCTCGCAGTATGAAC	0.483			NA											20	16					0	0	0.004656	0	0
DNAH5	1767	broad.mit.edu	37	5	13901490	13901490	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:13901490C>A	uc003jfd.2	-	14	1965	c.1923G>T	c.(1921-1923)ATG>ATT	p.M641I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	641	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGAAAAGCTGCATGGGCTGCT	0.537			NA							Kartagener_syndrome				13	31					1.49906e-05	1.66214e-05	0.00245	1	0
ANKH	56172	broad.mit.edu	37	5	14769115	14769115	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:14769115C>T	uc003jfm.3	-	2	613	c.282G>A	c.(280-282)GGG>GGA	p.G94G		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	94	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						CAGCGATGGCCCCTGCCACCA	0.502			NA											9	67					0	0	0.004007	0	0
ANKH	56172	broad.mit.edu	37	5	14769157	14769157	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:14769157C>G	uc003jfm.3	-	2	571	c.240G>C	c.(238-240)AAG>AAC	p.K80N		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	80	Cytoplasmic (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						TCCTGTCTCTCTTGCTGTTCA	0.572			NA											5	51					0	0	0.003163	0	0
ANKH	56172	broad.mit.edu	37	5	14769166	14769166	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:14769166C>G	uc003jfm.3	-	2	562	c.231G>C	c.(229-231)GTG>GTC	p.V77V		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	77	Cytoplasmic (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						TCTTGCTGTTCACAAACACCA	0.577			NA											5	49					0	0	0.00245	0	0
ANKH	56172	broad.mit.edu	37	5	14769270	14769270	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:14769270C>G	uc003jfm.3	-	2	458	c.127G>C	c.(127-129)GAG>CAG	p.E43Q		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	43	Cytoplasmic (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						ACTGCATCCTCCTTGACAGCA	0.522			NA											7	26					0	0	0.001984	0	0
CDH18	1016	broad.mit.edu	37	5	19544062	19544062	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:19544062T>A	uc003jgc.2	-	8	1683	c.1306A>T	c.(1306-1308)AAT>TAT	p.N436Y	CDH18_uc003jgd.2_Missense_Mutation_p.N436Y|CDH18_uc011cnm.1_Missense_Mutation_p.N436Y	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	436	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTCCCAGTATTGGCATCAATG	0.343			NA											17	16					0	0	0.006122	0	0
CDH9	1007	broad.mit.edu	37	5	26885762	26885762	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:26885762C>G	uc003jgs.1	-	11	2012	c.1843G>C	c.(1843-1845)GCT>CCT	p.A615P	CDH9_uc011cnv.1_Missense_Mutation_p.A208P	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	615	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GCAACGAGAGCTCCCGTGCTC	0.507	Melanoma(8;187 585 15745 40864 52829)		NA											9	28					0	0	0.000978	0	0
RNASEN	29102	broad.mit.edu	37	5	31495439	31495439	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:31495439C>A	uc003jhg.2	-	11	2068	c.1709G>T	c.(1708-1710)AGA>ATA	p.R570I	RNASEN_uc003jhh.2_Missense_Mutation_p.R533I|RNASEN_uc003jhi.2_Missense_Mutation_p.R533I|RNASEN_uc010iui.1_Missense_Mutation_p.R493I	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	570	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						GTGGAAAAGTCTGCCAGCATT	0.373			NA											26	13					7.61165e-28	1.1584e-27	0.003755	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33891862	33891862	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:33891862G>T	uc003jia.1	-	1	263	c.100C>A	c.(100-102)CCG>ACG	p.P34T	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P34T|ADAMTS12_uc003jib.1_Missense_Mutation_p.P34T	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	34					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAGCGAACCGGGCCTGGCTGA	0.527			NA								HNSCC(64;0.19)			77	48					9.37156e-40	1.48912e-39	0.00361	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41070950	41070950	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:41070950G>C	uc003jmj.3	-	1	495	c.5C>G	c.(4-6)ACA>AGA	p.T2R		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	2							binding			ovary(6)|central_nervous_system(2)	8						TGTACTAAGTGTCATGTCTTG	0.388			NA											3	5					0	0	0.009096	0	0
UTP15	84135	broad.mit.edu	37	5	72873801	72873801	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:72873801A>G	uc003kcw.1	+	9	1238	c.1015A>G	c.(1015-1017)ATT>GTT	p.I339V	UTP15_uc011cso.1_Missense_Mutation_p.I320V|UTP15_uc011csp.1_Missense_Mutation_p.I149V|UTP15_uc010ize.1_Missense_Mutation_p.I339V	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	339					rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TCGAACCTTTATTAAAGGAAA	0.378			NA											28	21					0	0	0.002445	0	0
OTP	23440	broad.mit.edu	37	5	76926342	76926342	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:76926342G>T	uc003kfg.2	-	3	873	c.725C>A	c.(724-726)GCG>GAG	p.A242E		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	242						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		CGGACCGGCCGCCAGGCTGCA	0.746			NA											9	5					1.08611e-07	1.26254e-07	0.000978	1	0
CMYA5	202333	broad.mit.edu	37	5	79030362	79030362	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:79030362G>T	uc003kgc.2	+	2	5846	c.5774G>T	c.(5773-5775)AGG>ATG	p.R1925M		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1925						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AATGAGCTGAGGCCAGGGCAG	0.493			NA											9	12					3.27435e-08	3.86864e-08	0.00245	1	0
ANKRD34B	340120	broad.mit.edu	37	5	79855544	79855544	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:79855544C>G	uc010jam.2	-	4	645	c.295G>C	c.(295-297)GAA>CAA	p.E99Q	ANKRD34B_uc003kgw.2_Missense_Mutation_p.E99Q|ANKRD34B_uc010jan.2_Missense_Mutation_p.E99Q	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	99	ANK 3.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		GAAACAACTTCAGGGCCAGCT	0.438			NA											18	96					0	0	0.010504	0	0
VCAN	1462	broad.mit.edu	37	5	82833991	82833991	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:82833991G>C	uc003kii.3	+	8	5525	c.5169G>C	c.(5167-5169)AAG>AAC	p.K1723N	VCAN_uc003kij.3_Missense_Mutation_p.K736N|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.K387N	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1723	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTGAGGAAAAGAAAAGGAAGG	0.408			NA											18	61					0	0	0.002299	0	0
FAM81B	153643	broad.mit.edu	37	5	94731844	94731844	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:94731844C>A	uc003kla.1	+	3	304	c.258C>A	c.(256-258)ACC>ACA	p.T86T	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	86										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AAATGTCAACCAAGAATTCTA	0.313			NA											35	32					1.8453e-21	2.68286e-21	0.002522	1	0
TTC37	9652	broad.mit.edu	37	5	94849318	94849318	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:94849318T>A	uc003klb.2	-	27	3005	c.2735A>T	c.(2734-2736)GAC>GTC	p.D912V		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	912							binding			ovary(3)|pancreas(1)	4						ATCCATGGTGTCATAACTTCC	0.328			NA											29	23					0	0	0.005524	0	0
YTHDC2	64848	broad.mit.edu	37	5	112889304	112889304	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:112889304C>G	uc003kqn.2	+	14	2068	c.1885C>G	c.(1885-1887)CTG>GTG	p.L629V	YTHDC2_uc010jce.1_Missense_Mutation_p.L629V|YTHDC2_uc010jcf.1_Missense_Mutation_p.L329V	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	629	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ACTAATTTTTCTGCCTGGATA	0.368			NA											15	62					0	0	0.008871	0	0
CEP120	153241	broad.mit.edu	37	5	122720712	122720712	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:122720712C>A	uc003ktk.2	-	12	1778	c.1696G>T	c.(1696-1698)GGT>TGT	p.G566C	CEP120_uc011cwq.1_Missense_Mutation_p.G375C|CEP120_uc010jcz.1_Missense_Mutation_p.G540C	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	566						centrosome				ovary(1)	1						CCATTAGAACCTAAAAAACGA	0.373			NA											7	53					2.74318e-10	3.40451e-10	0.006214	1	0
SLC12A2	6558	broad.mit.edu	37	5	127469953	127469953	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:127469953G>T	uc003kus.2	+	6	1449	c.1285G>T	c.(1285-1287)GAG>TAG	p.E429*	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Nonsense_Mutation_p.E429*	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	429	Helical; (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGCTGGAATGGAGTGGGAAGC	0.343			NA											36	75					1.58521e-26	2.40161e-26	0.005524	1	0
SLC12A2	6558	broad.mit.edu	37	5	127483319	127483319	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:127483319G>T	uc003kus.2	+	11	1943	c.1779G>T	c.(1777-1779)ATG>ATT	p.M593I	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.M593I	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	593	Helical; (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTAAGGTAATGAGTATGGTGT	0.338			NA											10	67					0.00829132	0.00866039	0.008291	1	0
FBN2	2201	broad.mit.edu	37	5	127800505	127800505	+	Silent	SNP	C	C	G	rs150087436	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:127800505C>G	uc003kuu.2	-	6	1177	c.738G>C	c.(736-738)GCG>GCC	p.A246A	FBN2_uc003kuv.2_Silent_p.A213A|FBN2_uc003kuw.3_Silent_p.A246A|FBN2_uc003kux.1_Silent_p.A246A	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	246	TB 1.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GATGGCCCCACGCCCGTCCAA	0.607			NA											14	75					0	0	0.004007	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130834300	130834300	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:130834300C>A	uc003kvn.1	-	12	1461	c.1255G>T	c.(1255-1257)GCA>TCA	p.A419S	RAPGEF6_uc003kvp.1_Missense_Mutation_p.A469S|RAPGEF6_uc003kvo.1_Missense_Mutation_p.A419S|RAPGEF6_uc010jdi.1_Missense_Mutation_p.A419S|RAPGEF6_uc010jdj.1_Missense_Mutation_p.A419S|RAPGEF6_uc003kvq.2_Missense_Mutation_p.A136S|RAPGEF6_uc003kvr.2_Missense_Mutation_p.A419S|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.A419S	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	419	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCAGGTGTTGCCTAAAAATCC	0.348	Melanoma(168;435 1955 13113 13877 23213)		NA											23	16					1.08312e-15	1.46694e-15	0.009535	1	0
CAMLG	819	broad.mit.edu	37	5	134077174	134077174	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:134077174T>C	uc003kzt.2	+	2	699	c.594T>C	c.(592-594)CTT>CTC	p.L198L	CAMLG_uc003kzu.2_Intron	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	198	Helical; (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	GATGTGCTCTTCTTGCTCTTG	0.323			NA											17	82					0	0	0.008871	0	0
PITX1	5307	broad.mit.edu	37	5	134364727	134364727	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:134364727C>T	uc010jea.2	-	3	1080	c.687G>A	c.(685-687)ATG>ATA	p.M229I	PITX1_uc011cxy.1_Missense_Mutation_p.M229I	NM_002653	NP_002644	P78337	PITX1_HUMAN	paired-like homeodomain transcription factor 1	229	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		CGCCTGGGCCCATGCTGGACG	0.627			NA											39	20					0	0	0.00361	0	0
FAM53C	51307	broad.mit.edu	37	5	137681183	137681183	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:137681183C>T	uc003lcv.2	+	4	1276	c.806C>T	c.(805-807)CCC>CTC	p.P269L	FAM53C_uc003lcw.2_Missense_Mutation_p.P269L|FAM53C_uc011cyq.1_RNA|FAM53C_uc011cyr.1_Missense_Mutation_p.P85S	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	269										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CGCAACCTTCCCCGAAGCCGC	0.667			NA											18	60					0	0	0.001882	0	0
KDM3B	51780	broad.mit.edu	37	5	137727918	137727918	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:137727918C>A	uc003lcy.1	+	8	2797	c.2597C>A	c.(2596-2598)CCC>CAC	p.P866H	KDM3B_uc010jew.1_Missense_Mutation_p.P522H|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	866					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AAGCAGGCCCCCAAGGGCCGG	0.607			NA											17	32					3.62473e-10	4.47657e-10	0.001882	1	0
CTNNA1	1495	broad.mit.edu	37	5	138269493	138269493	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:138269493G>A	uc003ldh.2	+	18	2531	c.2436G>A	c.(2434-2436)GTG>GTA	p.V812V	CTNNA1_uc011cyx.1_Silent_p.V709V|CTNNA1_uc011cyy.1_Silent_p.V689V|CTNNA1_uc003ldi.2_Silent_p.V510V|CTNNA1_uc003ldj.2_Nonsense_Mutation_p.W836*|CTNNA1_uc003ldl.2_Silent_p.V442V	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	812					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTCGTAGGTGGACAGCGCCA	0.582			NA											8	25					0	0	0.008291	0	0
PCDHA13	56136	broad.mit.edu	37	5	140389313	140389313	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:140389313G>T	uc003lif.2	+	4	2644	c.2644G>T	c.(2644-2646)GGT>TGT	p.G882C	PCDHA1_uc003lha.2_Missense_Mutation_p.G618C|PCDHA1_uc003lhb.2_Missense_Mutation_p.G882C|PCDHA2_uc003lhd.2_Missense_Mutation_p.G880C|PCDHA3_uc003lhf.2_Missense_Mutation_p.G882C|PCDHA4_uc003lhi.2_Missense_Mutation_p.G879C|PCDHA4_uc003lhh.1_Nonsense_Mutation_p.E879*|PCDHA5_uc003lhk.1_Nonsense_Mutation_p.E868*|PCDHA5_uc003lhl.2_Missense_Mutation_p.G868C|PCDHA6_uc003lhn.2_Missense_Mutation_p.G618C|PCDHA6_uc003lho.2_Missense_Mutation_p.G882C|PCDHA7_uc003lhq.2_Missense_Mutation_p.G869C|PCDHA8_uc003lhs.2_Missense_Mutation_p.G882C|PCDHA9_uc003lhu.2_Missense_Mutation_p.G882C|PCDHA10_uc003lhw.2_Missense_Mutation_p.G617C|PCDHA10_uc003lhx.2_Missense_Mutation_p.G880C|PCDHA11_uc003lia.2_Missense_Mutation_p.G881C|PCDHA12_uc003lic.2_Missense_Mutation_p.G873C|PCDHA13_uc003lie.1_Nonsense_Mutation_p.E882*|PCDHAC1_uc003lih.2_Missense_Mutation_p.G895C|PCDHAC2_uc003lii.2_Missense_Mutation_p.G939C	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	882	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCGGTCCCGGTGAGTTGCC	0.522	Melanoma(147;1739 1852 5500 27947 37288)		NA											13	59					4.36969e-10	5.39e-10	0.001855	1	0
PCDHB4	56131	broad.mit.edu	37	5	140501695	140501695	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:140501695G>C	uc003lip.1	+	1	115	c.115G>C	c.(115-117)GAG>CAG	p.E39Q		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	39	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGAAACAGAGAGCGGCTC	0.532			NA											11	47					0	0	0.001855	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140729927	140729927	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:140729927A>T	uc003ljo.1	+	1	100	c.100A>T	c.(100-102)ACG>TCG	p.T34S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.T34S	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCCGATACACGATTCCAGA	0.547			NA									OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	6					0	0	0.001368	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744112	140744112	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:140744112C>T	uc003lju.1	+	1	215	c.215C>T	c.(214-216)ACG>ATG	p.T72M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.T72M	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGTAGGACGCAGCTTTTT	0.642			NA											39	28					0	0	0.00361	0	0
GM2A	2760	broad.mit.edu	37	5	150632804	150632804	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:150632804C>T	uc003ltr.3	+	1	192	c.27C>T	c.(25-27)CTC>CTT	p.L9L	GM2A_uc011dcs.1_RNA|GM2A_uc011dcr.1_Silent_p.L9L	NM_000405	NP_000396	P17900	SAP3_HUMAN	GM2 ganglioside activator precursor	9						lysosome|nucleolus	sphingolipid activator protein activity				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGCTCCCCTCCTGATCGCCC	0.597			NA											12	67					0	0	0.003163	0	0
SPARC	6678	broad.mit.edu	37	5	151049324	151049324	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:151049324T>C	uc003luh.2	-	5	376	c.352A>G	c.(352-354)ACC>GCC	p.T118A	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Missense_Mutation_p.T118A	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	118	Kazal-like.				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	GAGTCGAAGGTCTTGTTGTCA	0.478			NA											58	39					0	0	0.00361	0	0
MRPL22	29093	broad.mit.edu	37	5	154346360	154346360	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:154346360G>T	uc003lvy.3	+	7	562	c.524G>T	c.(523-525)GGG>GTG	p.G175V	MRPL22_uc003lvz.3_Missense_Mutation_p.G95V	NM_014180	NP_054899	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22 isoform a	175					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTGGTGGAAGGGCCCCCACCT	0.537			NA											9	35					1.58986e-06	1.8065e-06	0.008291	1	0
SOX30	11063	broad.mit.edu	37	5	157073778	157073778	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:157073778T>C	uc003lxb.1	-	3	1596	c.1254A>G	c.(1252-1254)CTA>CTG	p.L418L	SOX30_uc003lxc.1_Silent_p.L418L|SOX30_uc011dds.1_Silent_p.L113L	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	418					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGAAACACTTAGAGGGAATC	0.383	Esophageal Squamous(31;525 799 19355 21125 41744)		NA											40	62					0	0	0.00361	0	0
GABRA6	2559	broad.mit.edu	37	5	161116337	161116337	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:161116337G>T	uc003lyu.2	+	5	862	c.524G>T	c.(523-525)GGG>GTG	p.G175V	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	175	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCAAGTTTGGGAGCTGTAAG	0.383			NA								TCGA Ovarian(5;0.080)			21	58					1.75199e-13	2.30476e-13	0.007291	1	0
BNIP1	662	broad.mit.edu	37	5	172571589	172571589	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:172571589A>C	uc003mcj.3	+	1	145	c.41A>C	c.(40-42)CAA>CCA	p.Q14P	BNIP1_uc003mci.3_Missense_Mutation_p.Q14P|BNIP1_uc003mck.3_Missense_Mutation_p.Q14P|BNIP1_uc003mcl.3_Missense_Mutation_p.Q14P	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1	14	Cytoplasmic (Potential).			Q -> R (in Ref. 3; AAO91805).	anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ATCTGTAACCAAGAGATTGTC	0.602			NA									OREG0017054	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	38					0	0	0.00308	0	0
NKX2-5	1482	broad.mit.edu	37	5	172659825	172659825	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:172659825T>A	uc003mcm.1	-	2	898	c.722A>T	c.(721-723)TAC>TTC	p.Y241F		NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	241	Ala/Pro-rich.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCCCACGCCGTAGGCAGGCGC	0.617	Esophageal Squamous(72;810 1219 2387 13420 44943)		NA											5	5					0	0	0.00308	0	0
HK3	3101	broad.mit.edu	37	5	176314064	176314064	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:176314064C>A	uc003mfa.2	-	13	1888	c.1796G>T	c.(1795-1797)GGG>GTG	p.G599V	HK3_uc003mez.2_Missense_Mutation_p.G155V	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	599	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGGCTCTGCCCGCTCAGGCC	0.607			NA											7	30					0.00307968	0.00323014	0.00308	1	0
RGS14	10636	broad.mit.edu	37	5	176795724	176795724	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:176795724C>T	uc003mgf.2	+	9	1038	c.856C>T	c.(856-858)CGG>TGG	p.R286W	RGS14_uc003mgg.1_Missense_Mutation_p.R133W|RGS14_uc003mgh.2_Missense_Mutation_p.R133W|RGS14_uc003mgi.2_Missense_Mutation_p.R56W|RGS14_uc003mgj.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	286					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCAGAGCCACCGGAAGAGCCT	0.582	NSCLC(47;353 1896 28036)		NA									OREG0017086	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0	0	0.00308	0	0
DUSP22	56940	broad.mit.edu	37	6	348818	348818	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:348818C>A	uc003msx.2	+	7	924	c.485C>A	c.(484-486)GCA>GAA	p.A162E	DUSP22_uc011dhn.1_Missense_Mutation_p.A162E|DUSP22_uc003msy.1_Missense_Mutation_p.A119E	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	162					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.A162V(1)		ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TTGCAGGATGCAGAAGAAGCC	0.557			NA											9	102					9.70103e-10	1.1908e-09	0.008291	1	0
F13A1	2162	broad.mit.edu	37	6	6251148	6251148	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:6251148G>T	uc003mwv.2	-	5	709	c.586C>A	c.(586-588)CTG>ATG	p.L196M	F13A1_uc011dib.1_Missense_Mutation_p.L133M	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	196					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCATTGTCCAGATACACAGCA	0.388			NA											39	168					3.54909e-21	5.14516e-21	0.002852	1	0
TFAP2A	7020	broad.mit.edu	37	6	10404842	10404842	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:10404842G>T	uc003myr.2	-	4	915	c.663C>A	c.(661-663)CTC>CTA	p.L221L	TFAP2A_uc003myq.2_Silent_p.L215L|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Silent_p.L221L|TFAP2A_uc003myt.2_Silent_p.L217L|TFAP2A_uc003myu.1_Silent_p.L221L	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	221					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGTGGAGCTGAGGAGCGAGA	0.622			NA											15	65					1.02788e-11	1.30786e-11	0.00499	1	0
HIVEP1	3096	broad.mit.edu	37	6	12163672	12163672	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:12163672C>G	uc003nac.2	+	9	7314	c.7135C>G	c.(7135-7137)CAT>GAT	p.H2379D	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2379					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCCCCACACTCATTTGTTTAG	0.532			NA											18	82					0	0	0.008871	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124824	26124824	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:26124824G>C	uc003ngm.2	+	1	452	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.E122Q	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	122					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TAAGAAGACCGAGAGTCACCA	0.562			NA											14	47					0	0	0.006122	0	0
BTN1A1	696	broad.mit.edu	37	6	26502076	26502076	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:26502076G>A	uc003nif.3	+	2	358	c.338G>A	c.(337-339)GGC>GAC	p.G113D		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	113	Extracellular (Potential).|Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGGATCCGTGGCGTCAGAGTC	0.647			NA											15	55					0	0	0.006122	0	0
ABT1	29777	broad.mit.edu	37	6	26598252	26598252	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:26598252G>T	uc003nii.2	+	2	383	c.352G>T	c.(352-354)GCC>TCC	p.A118S		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	118	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity	p.A118A(1)		ovary(1)	1						CAAGCGCATAGCCAAGCGCGT	0.577			NA											8	35					0.00621372	0.00649704	0.006214	1	0
OR10C1	442194	broad.mit.edu	37	6	29408157	29408157	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:29408157A>G	uc011dlp.1	+	1	365	c.365A>G	c.(364-366)TAT>TGT	p.Y122C	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATGACCGCTATGCAGCCATC	0.627			NA											12	40					0	0	0.00245	0	0
HLA-J	3137	broad.mit.edu	37	6	29977342	29977342	+	Missense_Mutation	SNP	A	A	T	rs113017032		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:29977342A>T	uc003rtl.3	+	5	723	c.361A>T	c.(361-363)AGG>TGG	p.R121W	HLA-G_uc011dmb.1_3'UTR|NCRNA00171_uc011dme.1_Intron|HLA-J_uc003nou.3_RNA|HLA-J_uc003nov.3_RNA					Homo sapiens major histocompatibility complex, class I, J (pseudogene), mRNA (cDNA clone IMAGE:4694038).												0						TGGGACTGAGAGGCAAGATTT	0.438			NA											3	45					0	0	0.001168	0	0
TRIM31	11074	broad.mit.edu	37	6	30071355	30071355	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:30071355C>T	uc003npg.1	-	9	1346	c.1236G>A	c.(1234-1236)CTG>CTA	p.L412L	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	412						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						GGATCGCTGTCAGCCACTCAC	0.552			NA											15	101					0	0	0.006122	0	0
APOM	55937	broad.mit.edu	37	6	31625865	31625865	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:31625865G>A	uc003nvl.2	+	6	639	c.566G>A	c.(565-567)TGA>TAA	p.*189*	APOM_uc003nvk.2_Silent_p.*117*	NM_019101	NP_061974	O95445	APOM_HUMAN	apolipoprotein M	189					cholesterol efflux|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|negative regulation of plasma lipoprotein particle oxidation|reverse cholesterol transport	discoidal high-density lipoprotein particle|integral to plasma membrane|low-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	binding|lipid transporter activity				0						TCCAATAACTGACCTGTAACT	0.502	Colon(39;129 858 13764 41453 42617)		NA											18	123					0	0	0.001882	0	0
SCUBE3	222663	broad.mit.edu	37	6	35209366	35209366	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:35209366C>G	uc003okf.1	+	11	1248	c.1242C>G	c.(1240-1242)CTC>CTG	p.L414L	SCUBE3_uc003okg.1_Silent_p.L413L|SCUBE3_uc003okh.1_Silent_p.L301L	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	414					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AAGCCATGCTCAGCTGCAACC	0.582			NA									OREG0017372	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	120					0	0	0.000978	0	0
C6orf222	389384	broad.mit.edu	37	6	36294441	36294441	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:36294441C>G	uc003oly.2	-	5	1060	c.882G>C	c.(880-882)AAG>AAC	p.K294N		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	294										skin(2)|ovary(1)|breast(1)	4						TTGAGGTTCTCTTGAGGCTTG	0.567			NA											32	270					0	0	0.002836	0	0
DNAH8	1769	broad.mit.edu	37	6	38705690	38705690	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:38705690C>T	uc003ooe.1	+	5	1007	c.407C>T	c.(406-408)TCA>TTA	p.S136L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GCCAGCAACTCAGAAACTGTT	0.393			NA											18	304					0	0	0.002299	0	0
ZNF318	24149	broad.mit.edu	37	6	43308097	43308097	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:43308097T>C	uc003oux.2	-	10	3717	c.3639A>G	c.(3637-3639)AAA>AAG	p.K1213K	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1213	Lys-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCTTTTTTTCTTTCTTCTCCT	0.483			NA											20	98					0	0	0.00333	0	0
PLA2G7	7941	broad.mit.edu	37	6	46690628	46690628	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:46690628T>A	uc010jzf.2	-	2	270	c.1A>T	c.(1-3)ATG>TTG	p.M1L	PLA2G7_uc010jzg.1_Missense_Mutation_p.M1L|PLA2G7_uc011dwd.1_Intron|PLA2G7_uc011dwe.1_Intron	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	1					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			GGTGGCACCATCTTGGGAGCT	0.438			NA											26	17					0	0	0.00632	0	0
GPR115	221393	broad.mit.edu	37	6	47682876	47682876	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:47682876C>A	uc003oza.1	+	6	2153	c.1895C>A	c.(1894-1896)ACG>AAG	p.T632K	GPR115_uc003oyz.1_Missense_Mutation_p.T689K|GPR115_uc003ozb.1_Missense_Mutation_p.T630K	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	632	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						ACTTCCTTGACGTTCCATATA	0.433	GBM(22;431 510 9010 26644 32828)		NA											35	95					6.2361e-21	8.97608e-21	0.007835	1	0
CRISP3	10321	broad.mit.edu	37	6	49698888	49698888	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:49698888C>T	uc003ozs.2	-	7	613	c.598G>A	c.(598-600)GAT>AAT	p.D200N		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	200					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CATAGTCCATCGTCACAGTTA	0.343			NA											33	47					0	0	0.004878	0	0
PKHD1	5314	broad.mit.edu	37	6	51712598	51712598	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:51712598G>T	uc003pah.1	-	50	8358	c.8082C>A	c.(8080-8082)AGC>AGA	p.S2694R	PKHD1_uc010jzn.1_Missense_Mutation_p.S677R|PKHD1_uc003pai.2_Missense_Mutation_p.S2694R	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2694	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GCCTCAGCTGGCTATTGAAGA	0.458			NA											38	66					4.44401e-20	6.3603e-20	0.002522	1	0
PKHD1	5314	broad.mit.edu	37	6	51889474	51889474	+	Missense_Mutation	SNP	C	C	A	rs141103838	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:51889474C>A	uc003pah.1	-	32	5410	c.5134G>T	c.(5134-5136)GGG>TGG	p.G1712W	PKHD1_uc003pai.2_Missense_Mutation_p.G1712W	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1712	IPT/TIG 12; atypical.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGGTACTCCCCGGCCGGAAGG	0.522			NA											20	47					3.62473e-10	4.47657e-10	0.001882	1	0
TINAG	27283	broad.mit.edu	37	6	54219322	54219322	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:54219322G>T	uc003pcj.2	+	9	1284	c.1138G>T	c.(1138-1140)GTC>TTC	p.V380F	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	380					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CATAATGCAAGTCCGTGAAGA	0.343			NA											7	42					6.31663e-08	7.38526e-08	0.003163	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62995788	62995788	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:62995788C>A	uc003peg.2	-	1	313	c.66G>T	c.(64-66)GTG>GTT	p.V22V		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		GCGACGCATGCACAAAAGATG	0.572			NA											16	19					2.94398e-08	3.49468e-08	0.007413	1	0
BAI3	577	broad.mit.edu	37	6	69666619	69666619	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:69666619C>A	uc003pev.3	+	8	1891	c.1443C>A	c.(1441-1443)ACC>ACA	p.T481T	BAI3_uc010kak.2_Silent_p.T481T	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	481	TSP type-1 4.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GAATAAGGACCTGTCAGGGTG	0.498			NA											49	87					2.79147e-13	3.64371e-13	0.00361	1	0
BAI3	577	broad.mit.edu	37	6	69785913	69785913	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:69785913G>C	uc003pev.3	+	17	2911	c.2463G>C	c.(2461-2463)TTG>TTC	p.L821F	BAI3_uc010kak.2_Missense_Mutation_p.L821F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	821	GPS.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATTGTGTATTGTGGGATGACT	0.333			NA											20	51					0	0	0.004656	0	0
COL19A1	1310	broad.mit.edu	37	6	70646688	70646689	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:70646688_70646689GG>TT	uc003pfc.1	+	8	876_877	c.759_760GG>TT	c.(757-762)CAGGAT>CATTAT	p.253_254QD>HY	COL19A1_uc010kam.1_Missense_Mutation_p.149_150QD>HY	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	253_254					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GCCCAGAGCAGGATGGCTTTGG	0.441			NA											20	76					0	0	0.004672	0	0
COL19A1	1310	broad.mit.edu	37	6	70897948	70897948	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:70897948C>T	uc003pfc.1	+	47	3143	c.3026C>T	c.(3025-3027)CCG>CTG	p.P1009L		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1009	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CCTGGCATTCCGGTAAGTAGT	0.522			NA											10	14					0	0	0.001368	0	0
FAM135A	57579	broad.mit.edu	37	6	71234590	71234590	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:71234590G>C	uc003pfj.2	+	13	1936	c.1803G>C	c.(1801-1803)TTG>TTC	p.L601F	FAM135A_uc003pfi.2_Intron|FAM135A_uc003pfh.2_Intron|FAM135A_uc003pfl.2_Intron|FAM135A_uc003pfn.2_Intron|FAM135A_uc003pfo.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	601										central_nervous_system(1)	1						TTGATCCTTTGAACTCTGGCA	0.383			NA											3	20					0	0	0.004672	0	0
FILIP1	27145	broad.mit.edu	37	6	76124490	76124490	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:76124490G>A	uc003pia.2	-	2	572	c.199C>T	c.(199-201)CGA>TGA	p.R67*	FILIP1_uc003phy.1_Nonsense_Mutation_p.R67*|FILIP1_uc010kbe.2_Nonsense_Mutation_p.R70*	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	67										skin(3)|ovary(1)	4						TTAGTTTTTCGTTCACATTCT	0.408			NA											23	175					0	0	0.00333	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84563413	84563413	+	Splice_Site	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:84563413G>T	uc003pke.2	+	2	247	c.96_splice	c.e2-1	p.G32_splice		NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein						somite rostral/caudal axis specification	nucleus					0						CTATCCCGCAGATACGCAGGC	0.672			NA											7	4					9.31168e-06	1.03818e-05	0.001855	1	0
ASCC3	10973	broad.mit.edu	37	6	101053536	101053536	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:101053536G>A	uc003pqk.2	-	33	5414	c.5085C>T	c.(5083-5085)TTC>TTT	p.F1695F		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1695	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTTGGTCATCGAACTGCGGCC	0.373			NA											11	48					0	0	0.001855	0	0
SCML4	256380	broad.mit.edu	37	6	108066223	108066223	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:108066223G>T	uc010kdf.2	-	5	863	c.612C>A	c.(610-612)CAC>CAA	p.H204Q	SCML4_uc003prz.3_Missense_Mutation_p.H146Q|SCML4_uc011eam.1_Missense_Mutation_p.H204Q|SCML4_uc003psa.3_Missense_Mutation_p.H175Q	NM_198081	NP_932347	Q8N228	SCML4_HUMAN	sex comb on midleg-like 4	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GGAAGGGCTGGTGGCTGAAGA	0.612			NA											9	53					0.000673444	0.000717534	0.008291	1	0
HS3ST5	222537	broad.mit.edu	37	6	114378531	114378531	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:114378531G>T	uc003pwg.3	-	2	963	c.931C>A	c.(931-933)CGC>AGC	p.R311S	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.R311S	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	311	PAPS (By similarity).|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGATGAATGCGCCCCTTGCTG	0.398			NA											28	47					6.07407e-21	8.76775e-21	0.007291	1	0
DSE	29940	broad.mit.edu	37	6	116747753	116747753	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:116747753C>T	uc003pws.2	+	3	627	c.433C>T	c.(433-435)CCT>TCT	p.P145S	DSE_uc011ebf.1_Missense_Mutation_p.P145S|DSE_uc011ebg.1_Missense_Mutation_p.P164S|DSE_uc003pwt.2_Missense_Mutation_p.P145S	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	145					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GAAAGATGCTCCTTGGGATGA	0.433			NA											33	44					0	0	0.005524	0	0
TRDN	10345	broad.mit.edu	37	6	123591004	123591004	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:123591004G>T	uc003pzj.1	-	31	1750	c.1728C>A	c.(1726-1728)CCC>CCA	p.P576P	TRDN_uc010kem.1_Silent_p.P77P	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	576	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		TTGTTGGTTTGGGCTTGGCTG	0.323			NA											6	22					2.74318e-10	3.40451e-10	0.006214	1	0
LAMA2	3908	broad.mit.edu	37	6	129468115	129468115	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:129468115G>T	uc003qbn.2	+	6	936	c.831G>T	c.(829-831)TCG>TCT	p.S277S	LAMA2_uc003qbo.2_Silent_p.S277S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	277	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATTACTACTCGGTCAAGGATA	0.398			NA											19	94					1.9806e-07	2.29177e-07	0.002299	1	0
LAMA2	3908	broad.mit.edu	37	6	129513894	129513894	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:129513894G>A	uc003qbn.2	+	12	1783	c.1678G>A	c.(1678-1680)GAC>AAC	p.D560N	LAMA2_uc003qbo.2_Missense_Mutation_p.D560N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	560	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCAGCAGGACGACTTGGACTC	0.547			NA											32	34					0	0	0.004878	0	0
LAMA2	3908	broad.mit.edu	37	6	129826417	129826417	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:129826417A>T	uc003qbn.2	+	60	8725	c.8620A>T	c.(8620-8622)AAA>TAA	p.K2874*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.K2870*|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2874	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CATCAGTCCCAAAAAAGCCGA	0.403			NA											21	31					0	0	0.00278	0	0
C6orf191	253582	broad.mit.edu	37	6	130166922	130166922	+	Missense_Mutation	SNP	C	C	T	rs143949103	by1000genomes	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:130166922C>T	uc003qbs.2	-	2	192	c.109G>A	c.(109-111)GTG>ATG	p.V37M		NM_001010876	NP_001010876	Q5VVB8	CF191_HUMAN	hypothetical protein LOC253582	37	Helical; (Potential).					integral to membrane		p.V37M(1)		large_intestine(1)	1				GBM - Glioblastoma multiforme(226;0.0387)|all cancers(137;0.115)|OV - Ovarian serous cystadenocarcinoma(155;0.131)		TCAAACATCACGCAGCCCATG	0.358			NA											27	40					0	0	0.003755	0	0
SHPRH	257218	broad.mit.edu	37	6	146266723	146266723	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:146266723C>A	uc003qlf.2	-	8	1771	c.1372G>T	c.(1372-1374)GGA>TGA	p.G458*	SHPRH_uc003qld.2_Nonsense_Mutation_p.G458*|SHPRH_uc003qle.2_Nonsense_Mutation_p.G458*|SHPRH_uc003qlg.1_Nonsense_Mutation_p.G14*|SHPRH_uc003qlj.1_Nonsense_Mutation_p.G347*	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	458	H15.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		ATGGACACTCCTTTTTTTCCA	0.328			NA											8	9					1.26484e-09	1.54882e-09	0.00308	1	0
AKAP12	9590	broad.mit.edu	37	6	151672917	151672917	+	Missense_Mutation	SNP	G	G	C	rs142987485		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:151672917G>C	uc011eep.1	+	4	3631	c.3391G>C	c.(3391-3393)GAG>CAG	p.E1131Q	AKAP12_uc003qoe.2_Missense_Mutation_p.E1131Q|AKAP12_uc003qof.2_Missense_Mutation_p.E1033Q|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.E1026Q	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1131					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGAGAGCATAGAGTCCAGTGA	0.512	Melanoma(141;1616 1805 10049 24534 51979)		NA											8	23					0	0	0.004482	0	0
ARID1B	57492	broad.mit.edu	37	6	157522225	157522225	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:157522225G>C	uc003qqn.2	+	18	4595	c.4443G>C	c.(4441-4443)ATG>ATC	p.M1481I	ARID1B_uc003qqo.2_Missense_Mutation_p.M1441I|ARID1B_uc003qqp.2_Missense_Mutation_p.M1428I	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1486	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGACGATATGATGGTACCCG	0.572			NA											19	52					0	0	0.010504	0	0
TULP4	56995	broad.mit.edu	37	6	158902115	158902115	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:158902115G>C	uc003qrf.2	+	8	2637	c.1280G>C	c.(1279-1281)AGA>ACA	p.R427T	TULP4_uc011efo.1_Missense_Mutation_p.R427T|TULP4_uc003qrg.2_Missense_Mutation_p.R427T	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	427					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		AACAACATGAGAGACTTTGTC	0.587			NA											22	52					0	0	0.007291	0	0
FNDC1	84624	broad.mit.edu	37	6	159654537	159654537	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:159654537C>A	uc010kjv.2	+	11	3193	c.2993C>A	c.(2992-2994)CCC>CAC	p.P998H	FNDC1_uc010kjw.1_Missense_Mutation_p.P883H	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	998						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGGATGACACCCGGCCGGGCC	0.706			NA											6	8					0.000978159	0.00104	0.000978	1	0
LPA	4018	broad.mit.edu	37	6	161016500	161016500	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:161016500G>T	uc003qtl.2	-	22	3475	c.3355C>A	c.(3355-3357)CCC>ACC	p.P1119T		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3627	Kringle 32.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CTGACACTGGGATCCATGGTG	0.522			NA											42	50					2.24059e-37	3.53796e-37	0.00361	1	0
MACC1	346389	broad.mit.edu	37	7	20198817	20198817	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:20198817T>C	uc003sus.3	-	5	1476	c.1167A>G	c.(1165-1167)ACA>ACG	p.T389T	MACC1_uc010kug.2_Silent_p.T389T	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	389					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GTCCACAAACTGTTAAAACAA	0.403			NA											7	38					0	0	0.00308	0	0
ABCB5	340273	broad.mit.edu	37	7	20725427	20725427	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:20725427G>C	uc003suw.3	+	7	1189	c.643G>C	c.(643-645)GAC>CAC	p.D215H	ABCB5_uc010kuh.2_Missense_Mutation_p.D660H	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	215	Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AGACTTCATTGACAAGGCTGA	0.388			NA											23	36					0	0	0.00632	0	0
OSBPL3	26031	broad.mit.edu	37	7	24846453	24846453	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:24846453C>G	uc003sxf.2	-	21	2791	c.2386G>C	c.(2386-2388)GAT>CAT	p.D796H	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.D760H|OSBPL3_uc003sxh.2_Missense_Mutation_p.D765H|OSBPL3_uc003sxi.2_Missense_Mutation_p.D729H	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	796					lipid transport		lipid binding|protein binding			skin(1)	1						GATGATGGATCCATTTCATTT	0.383			NA											13	67					0	0	0.004007	0	0
TXNDC3	51314	broad.mit.edu	37	7	37890266	37890266	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:37890266A>G	uc003tfn.2	+	5	499	c.127A>G	c.(127-129)AGA>GGA	p.R43G		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	43	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TGGACCTTGCAGAGCAATGCA	0.353	Ovarian(108;903 1537 27096 29907 47400)		NA							Kartagener_syndrome				13	74					0	0	0.006122	0	0
SFRP4	6424	broad.mit.edu	37	7	37956065	37956065	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:37956065C>T	uc003tfo.3	-	1	461	c.75G>A	c.(73-75)GAG>GAA	p.E25E		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	25	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TGCGCACCGCCTCGCAGGGCG	0.687			NA											12	36					0	0	0.001855	0	0
INHBA	3624	broad.mit.edu	37	7	41729708	41729708	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:41729708C>A	uc003thq.2	-	2	1056	c.821G>T	c.(820-822)GGA>GTA	p.G274V	INHBA_uc003thr.2_Missense_Mutation_p.G274V	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	274					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						accttcacctccgcccttctt	0.363			NA								TSP Lung(11;0.080)			4	21					0.00909568	0.00941286	0.009096	1	0
GLI3	2737	broad.mit.edu	37	7	42005202	42005202	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:42005202C>T	uc011kbh.1	-	15	3560	c.3469G>A	c.(3469-3471)GAC>AAC	p.D1157N	GLI3_uc011kbg.1_Missense_Mutation_p.D1098N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1157					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATGGGCAGGTCGGTTTTGCTG	0.692			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				30	105					0	0	0.003755	0	0
HECW1	23072	broad.mit.edu	37	7	43508550	43508550	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:43508550G>T	uc003tid.1	+	16	3550	c.2945G>T	c.(2944-2946)TGC>TTC	p.C982F	HECW1_uc011kbi.1_Missense_Mutation_p.C948F	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	982					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGTAGCACCTGCTTAAAGCAC	0.502			NA											38	36					5.20006e-24	7.70464e-24	0.002852	1	0
CAMK2B	816	broad.mit.edu	37	7	44281927	44281927	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:44281927C>T	uc003tkq.2	-	10	919	c.709G>A	c.(709-711)GAG>AAG	p.E237K	CAMK2B_uc003tkp.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkx.2_Missense_Mutation_p.E237K|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.E237K|CAMK2B_uc003tks.2_Missense_Mutation_p.E237K|CAMK2B_uc003tku.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkv.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkt.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkw.2_Missense_Mutation_p.E237K|CAMK2B_uc010kyc.2_Missense_Mutation_p.E237K	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	237	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						GTGTCCCACTCAGGGGACGGG	0.607			NA											8	96					0	0	0.008291	0	0
OGDH	4967	broad.mit.edu	37	7	44747304	44747304	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:44747304C>T	uc003tln.2	+	22	3029	c.2920C>T	c.(2920-2922)CGG>TGG	p.R974W	OGDH_uc011kbx.1_Missense_Mutation_p.R970W|OGDH_uc011kby.1_Missense_Mutation_p.R824W|OGDH_uc003tlp.2_Missense_Mutation_p.R985W|OGDH_uc011kbz.1_Missense_Mutation_p.R769W	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	974					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GCCAAGACTTCGGACCACCAT	0.607			NA											9	69					0	0	0.006214	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44801331	44801331	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:44801331G>A	uc003tlr.2	+	11	1546	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	ZMIZ2_uc003tlq.2_Missense_Mutation_p.E417K|ZMIZ2_uc003tls.2_Missense_Mutation_p.E449K|ZMIZ2_uc003tlt.2_Missense_Mutation_p.E98K|ZMIZ2_uc010kyj.2_5'UTR	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	475	Interaction with AR.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CTACCACCACGAGGACCGGCA	0.602	NSCLC(20;604 852 1948 16908 50522)		NA											17	23					0	0	0.004007	0	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:57187809T>G	uc010kzo.2	-	5	1584	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453			NA											5	72					0	0	0.001168	0	0
PCLO	27445	broad.mit.edu	37	7	82584891	82584891	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:82584891C>A	uc003uhx.2	-	5	5667	c.5378G>T	c.(5377-5379)AGG>ATG	p.R1793M	PCLO_uc003uhv.2_Missense_Mutation_p.R1793M	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1724					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCTATTTCCCTCTGCTTTTC	0.393			NA											23	19					1.50039e-11	1.90188e-11	0.001882	1	0
PCLO	27445	broad.mit.edu	37	7	82584893	82584893	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:82584893C>A	uc003uhx.2	-	5	5665	c.5376G>T	c.(5374-5376)CAG>CAT	p.Q1792H	PCLO_uc003uhv.2_Missense_Mutation_p.Q1792H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1723					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTATTTCCCTCTGCTTTTCTT	0.398			NA											20	20					5.03518e-11	6.33479e-11	0.007413	1	0
SEMA3E	9723	broad.mit.edu	37	7	83022004	83022004	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:83022004C>A	uc003uhy.1	-	14	2000	c.1534G>T	c.(1534-1536)GCT>TCT	p.A512S		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	512	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CTGACTTGAGCCACAGCAGAA	0.473			NA											41	23					8.86878e-18	1.24114e-17	0.00361	1	0
CLDN12	9069	broad.mit.edu	37	7	90042003	90042003	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:90042003G>A	uc003ukp.2	+	5	649	c.13G>A	c.(13-15)GAT>AAT	p.D5N	CLDN12_uc003ukq.2_Missense_Mutation_p.D5N|CLDN12_uc010leq.2_Missense_Mutation_p.D5N|CLDN12_uc003ukr.2_Missense_Mutation_p.D5N|CLDN12_uc003uks.2_Missense_Mutation_p.D5N	NM_012129	NP_036261	P56749	CLD12_HUMAN	claudin 12	5	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GGGCTGTCGGGATGTCCACGC	0.532			NA											31	39					0	0	0.006999	0	0
TSC22D4	81628	broad.mit.edu	37	7	100075039	100075039	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:100075039C>G	uc003uva.2	-	2	1378	c.623G>C	c.(622-624)CGG>CCG	p.R208P	TSC22D4_uc003uvb.2_5'UTR|TSC22D4_uc011kjv.1_5'UTR|TSC22D4_uc010lgx.2_Missense_Mutation_p.R208P|TSC22D4_uc003uvc.3_Missense_Mutation_p.R208P	NM_030935	NP_112197	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	208					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGTGGCAGCCCGGGATGTGCC	0.692			NA											9	8					0	0	0.004482	0	0
MUC17	140453	broad.mit.edu	37	7	100693917	100693917	+	Splice_Site	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:100693917G>T	uc003uxp.1	+	7	12927	c.12874_splice	c.e7+1	p.D4292_splice	MUC17_uc010lho.1_Intron	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor							extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATTTGCTCAGGTGAACTCTGG	0.463			NA											11	10					0.00010058	0.000109595	0.001368	1	0
RELN	5649	broad.mit.edu	37	7	103163886	103163886	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:103163886C>T	uc003vca.2	-	47	7602	c.7442G>A	c.(7441-7443)TGC>TAC	p.C2481Y	RELN_uc010liz.2_Missense_Mutation_p.C2481Y	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2481	EGF-like 6.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CATGTCTATGCAGCCATCCCC	0.478	NSCLC(146;835 1944 15585 22231 52158)		NA											22	79					0	0	0.005443	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128505563	128505563	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:128505563A>T	uc003voc.1	+	2	352	c.291A>T	c.(289-291)CCA>CCT	p.P97P	KCP_uc003vob.1_Intron	NM_004231	NP_004222	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kD, V1	97					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						AGGAGCACCCATATGACGCCG	0.632			NA											19	12					0	0	0.00278	0	0
FAM40B	57464	broad.mit.edu	37	7	129120676	129120676	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:129120676C>G	uc011koy.1	+	19	2035	c.1995C>G	c.(1993-1995)ATC>ATG	p.I665M	FAM40B_uc003vow.2_Missense_Mutation_p.I665M|FAM40B_uc011koz.1_Missense_Mutation_p.I157M	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	665											0						TTTCCTGCATCAACCTCCTGA	0.433			NA											19	81					0	0	0.002299	0	0
PLXNA4	91584	broad.mit.edu	37	7	131844347	131844347	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:131844347G>T	uc003vra.3	-	25	4774	c.4545C>A	c.(4543-4545)GTC>GTA	p.V1515V		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1515	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TCTTTACTGGGACCTCGGGGC	0.532			NA											149	78					2.1406e-88	3.51198e-88	0.00361	1	0
NUP205	23165	broad.mit.edu	37	7	135322691	135322691	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:135322691G>T	uc003vsw.2	+	37	5180	c.5149G>T	c.(5149-5151)GGA>TGA	p.G1717*	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1717					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CCAGTGCTTAGGACTACTAAG	0.373			NA											5	30					0.00198382	0.00208943	0.001984	1	0
SLC13A4	26266	broad.mit.edu	37	7	135376299	135376299	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:135376299C>G	uc003vta.2	-	12	2004	c.1315G>C	c.(1315-1317)GAT>CAT	p.D439H	SLC13A4_uc003vtb.2_Missense_Mutation_p.D440H|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	439						integral to plasma membrane	sodium:sulfate symporter activity				0						CTCTCACCATCATTCTTTTTC	0.468			NA											7	27					0	0	0.001984	0	0
CHRM2	1129	broad.mit.edu	37	7	136699780	136699780	+	Silent	SNP	C	C	A	rs78847341		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:136699780C>A	uc003vtf.1	+	4	791	c.168C>A	c.(166-168)ACC>ACA	p.T56T	CHRM2_uc003vtg.1_Silent_p.T56T|CHRM2_uc003vtj.1_Silent_p.T56T|CHRM2_uc003vtk.1_Silent_p.T56T|CHRM2_uc003vtl.1_Silent_p.T56T|CHRM2_uc003vtm.1_Silent_p.T56T|CHRM2_uc003vti.1_Silent_p.T56T|CHRM2_uc003vto.1_Silent_p.T56T|CHRM2_uc003vtn.1_Silent_p.T56T|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	56	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACCTCCAGACCGTCAACAATT	0.458			NA											56	35					4.09171e-25	6.1073e-25	0.00361	1	0
CHRM2	1129	broad.mit.edu	37	7	136700015	136700016	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:136700015_136700016CG>AA	uc003vtf.1	+	4	1026_1027	c.403_404CG>AA	c.(403-405)CGG>AAG	p.R135K	CHRM2_uc003vtg.1_Missense_Mutation_p.R135K|CHRM2_uc003vtj.1_Missense_Mutation_p.R135K|CHRM2_uc003vtk.1_Missense_Mutation_p.R135K|CHRM2_uc003vtl.1_Missense_Mutation_p.R135K|CHRM2_uc003vtm.1_Missense_Mutation_p.R135K|CHRM2_uc003vti.1_Missense_Mutation_p.R135K|CHRM2_uc003vto.1_Missense_Mutation_p.R135K|CHRM2_uc003vtn.1_Missense_Mutation_p.R135K|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	135	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCCAGTCAAGCGGACCACAAAA	0.5			NA											21	37					0	0	0.004672	0	0
CHRM2	1129	broad.mit.edu	37	7	136700405	136700405	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:136700405G>T	uc003vtf.1	+	4	1416	c.793G>T	c.(793-795)GCC>TCC	p.A265S	CHRM2_uc003vtg.1_Missense_Mutation_p.A265S|CHRM2_uc003vtj.1_Missense_Mutation_p.A265S|CHRM2_uc003vtk.1_Missense_Mutation_p.A265S|CHRM2_uc003vtl.1_Missense_Mutation_p.A265S|CHRM2_uc003vtm.1_Missense_Mutation_p.A265S|CHRM2_uc003vti.1_Missense_Mutation_p.A265S|CHRM2_uc003vto.1_Missense_Mutation_p.A265S|CHRM2_uc003vtn.1_Missense_Mutation_p.A265S|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	265	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GAATGGCAAAGCCCCCAGGGA	0.493			NA											17	19					6.94344e-10	8.55425e-10	0.006122	1	0
DGKI	9162	broad.mit.edu	37	7	137293787	137293787	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:137293787A>T	uc003vtt.2	-	10	1093	c.1092T>A	c.(1090-1092)TTT>TTA	p.F364L	DGKI_uc003vtu.2_Missense_Mutation_p.F64L	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	364					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTTTATCACAAAAGGACGAC	0.433			NA											25	37					0	0	0.009535	0	0
Unknown	0	broad.mit.edu	37	7	142510430	142510430	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:142510430C>A	uc003wbp.2	-	2	288	c.176G>T	c.(175-177)AGG>ATG	p.R59M						SubName: Full=V_segment translation product; Flags: Fragment;												NA						CTGGAGGCCCCTGCCTGCAGC	0.612			NA											4	8					0.00909568	0.00941286	0.009096	1	0
OR6B1	135946	broad.mit.edu	37	7	143701627	143701627	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:143701627G>T	uc003wdt.1	+	1	538	c.538G>T	c.(538-540)GAC>TAC	p.D180Y		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					CTTCTTCTGTGACATCTCTCC	0.478			NA											14	42					6.31663e-08	7.38526e-08	0.003163	1	0
AGAP3	116988	broad.mit.edu	37	7	150840846	150840846	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:150840846G>T	uc003wjg.1	+	18	2555	c.2552G>T	c.(2551-2553)CGG>CTG	p.R851L	AGAP3_uc003wje.1_Missense_Mutation_p.R520L|AGAP3_uc003wjj.1_Missense_Mutation_p.R350L|AGAP3_uc003wjk.1_Missense_Mutation_p.R269L	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	815					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GTGAGGAGCCGGGACGCCCGG	0.602			NA											39	18					1.30916e-28	1.99841e-28	0.00361	1	0
NCAPG2	54892	broad.mit.edu	37	7	158455020	158455020	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:158455020T>C	uc003wnv.1	-	16	2000	c.1855A>G	c.(1855-1857)ATG>GTG	p.M619V	NCAPG2_uc010lqu.1_Missense_Mutation_p.M411V|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.M619V|NCAPG2_uc011kwe.1_Missense_Mutation_p.M619V|NCAPG2_uc011kwc.1_Missense_Mutation_p.M120V|NCAPG2_uc011kwd.1_Intron	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	619					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		AAACCTGCCATGCATGCAACA	0.328			NA											7	46					0	0	0.00308	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497408	1497408	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:1497408G>A	uc003wpl.2	+	2	646	c.549G>A	c.(547-549)GCG>GCA	p.A183A	DLGAP2_uc003wpm.2_Silent_p.A183A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	262					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGGCCGGGCGGACGACCACC	0.667			NA											2	3					0	0	0.004672	0	0
RP1L1	94137	broad.mit.edu	37	8	10466103	10466103	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:10466103T>C	uc003wtc.2	-	4	5734	c.5505A>G	c.(5503-5505)ATA>ATG	p.I1835M		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1835					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCGGGGCCTCTATGCCTTCGG	0.637			NA											56	129					0	0	0.00361	0	0
PINX1	54984	broad.mit.edu	37	8	10623297	10623297	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:10623297C>T	uc003wth.2	-	7	634	c.601G>A	c.(601-603)GAC>AAC	p.D201N	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_Silent_p.*175*	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	201					mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		TCAGAAATGTCAGACCCTGGA	0.512			NA											42	119					0	0	0.00361	0	0
DLC1	10395	broad.mit.edu	37	8	13356917	13356917	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:13356917C>T	uc003wwm.2	-	2	1108	c.664G>A	c.(664-666)GAG>AAG	p.E222K	DLC1_uc003wwn.2_Missense_Mutation_p.E222K|DLC1_uc011kxy.1_Missense_Mutation_p.E222K	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	222					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AATTGTTTCTCAGGTGCAATA	0.383			NA											26	101					0	0	0.009535	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19362965	19362965	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:19362965C>A	uc011kyn.1	-	4	1445	c.381G>T	c.(379-381)CAG>CAT	p.Q127H	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.Q127H|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.Q126H|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	127	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		CCTTGTCCACCTGCGAGTGCA	0.592			NA											24	52					8.16721e-17	1.12732e-16	0.002096	1	0
FZD3	7976	broad.mit.edu	37	8	28378250	28378250	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:28378250C>G	uc003xgx.2	+	4	763	c.285C>G	c.(283-285)GTC>GTG	p.V95V	FZD3_uc010lvb.2_Silent_p.V95V	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	95	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		ATGGACGTGTCACACTTCCCT	0.488			NA											48	133					0	0	0.00361	0	0
TEX15	56154	broad.mit.edu	37	8	30703622	30703622	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:30703622T>C	uc003xil.2	-	1	2912	c.2912A>G	c.(2911-2913)GAA>GGA	p.E971G		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	971										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATGTGCTTTTCTGACTGTGA	0.353			NA											23	40					0	0	0.002096	0	0
TEX15	56154	broad.mit.edu	37	8	30705432	30705432	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:30705432C>T	uc003xil.2	-	1	1102	c.1102G>A	c.(1102-1104)GGG>AGG	p.G368R		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	368										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTATTTTCCCCAATTTCAGT	0.383			NA											5	17					0	0	0.001168	0	0
IKBKB	3551	broad.mit.edu	37	8	42179970	42179970	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:42179970G>T	uc003xow.1	+	19	2121	c.1944G>T	c.(1942-1944)GAG>GAT	p.E648D	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.E425D|IKBKB_uc003xox.1_Missense_Mutation_p.E369D|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.E646D|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.E589D	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	648					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GGCTGCAGGAGAAGCGGCAGA	0.562			NA											24	94					7.26314e-15	9.71951e-15	0.007291	1	0
SNTG1	54212	broad.mit.edu	37	8	51705360	51705360	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:51705360A>G	uc010lxy.1	+	20	1896	c.1525A>G	c.(1525-1527)ACC>GCC	p.T509A	SNTG1_uc003xqs.1_Missense_Mutation_p.T509A|SNTG1_uc010lxz.1_Missense_Mutation_p.T472A|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	509					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CAGCTCTGCTACCACGAGCAA	0.433			NA											25	56					0	0	0.008361	0	0
C8orf46	254778	broad.mit.edu	37	8	67422362	67422362	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:67422362G>A	uc003xwg.2	+	4	705	c.312G>A	c.(310-312)CTG>CTA	p.L104L	C8orf46_uc003xwh.2_RNA|C8orf46_uc011let.1_Intron|C8orf46_uc003xwi.2_Translation_Start_Site	NM_152765	NP_689978	Q8TAG6	CH046_HUMAN	hypothetical protein LOC254778	104								p.C104W(1)|p.C104Y(1)		skin(2)	2			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CATCAAATCTGTGTGGGAATC	0.433			NA											16	64					0	0	0.006122	0	0
C8orf45	157777	broad.mit.edu	37	8	67791074	67791074	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:67791074C>G	uc003xwz.3	+	7	800	c.629C>G	c.(628-630)GCC>GGC	p.A210G	C8orf45_uc003xwv.2_Missense_Mutation_p.A210G|C8orf45_uc011lev.1_Missense_Mutation_p.A210G|C8orf45_uc011lew.1_Missense_Mutation_p.A141G|C8orf45_uc011lex.1_5'UTR|C8orf45_uc003xwy.3_Missense_Mutation_p.A210G	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	210					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAAATAATTGCCACAAAGGCA	0.279			NA											12	26					0	0	0.003163	0	0
PRDM14	63978	broad.mit.edu	37	8	70978496	70978496	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:70978496C>A	uc003xym.2	-	5	1359	c.1157G>T	c.(1156-1158)GGG>GTG	p.G386V		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TGGCTGCTTCCCCGGCTCTGT	0.537	NSCLC(129;99 1813 5906 40656 46114)		NA											18	41					4.26978e-12	5.46727e-12	0.00333	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75927069	75927069	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:75927069C>T	uc003yan.2	+	6	1024	c.649C>T	c.(649-651)CCT>TCT	p.P217S	CRISPLD1_uc011lfk.1_Missense_Mutation_p.P29S|CRISPLD1_uc011lfl.1_Missense_Mutation_p.P29S	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	217						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GGGCCATGCCCCTTACAAACA	0.423			NA											6	19					0	0	0.001168	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619980	77619980	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:77619980C>A	uc003yav.2	+	3	3099	c.2712C>A	c.(2710-2712)CTC>CTA	p.L904L	ZFHX4_uc003yat.1_Silent_p.L904L|ZFHX4_uc003yau.1_Silent_p.L930L|ZFHX4_uc003yaw.1_Silent_p.L904L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	904						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCGCTCTCTCCCTGAAGAGG	0.512			NA								HNSCC(33;0.089)			7	17					3.09899e-07	3.55731e-07	0.004482	1	0
TPD52	7163	broad.mit.edu	37	8	80976712	80976712	+	Splice_Site	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:80976712C>A	uc003ybr.1	-	2	577	c.255_splice	c.e2+1	p.K85_splice	TPD52_uc010lzr.2_Splice_Site|TPD52_uc010lzs.1_Splice_Site|TPD52_uc003ybs.1_Splice_Site_p.K45_splice|TPD52_uc003ybt.1_Splice_Site_p.K45_splice|TPD52_uc003ybq.1_Intron|TPD52_uc003ybu.1_Intron	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1						anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TGGTTCTTTACCTTTGCAAGT	0.428			NA											17	47					1.02788e-11	1.30786e-11	0.00499	1	0
RALYL	138046	broad.mit.edu	37	8	85441665	85441665	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:85441665G>A	uc003ycq.3	+	3	525	c.109G>A	c.(109-111)GAC>AAC	p.D37N	RALYL_uc003ycr.3_Missense_Mutation_p.D37N|RALYL_uc003ycs.3_Missense_Mutation_p.D37N|RALYL_uc010lzy.2_Missense_Mutation_p.D37N|RALYL_uc003yct.3_Missense_Mutation_p.D50N	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	37	RRM.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CAAGAAAGTTGACATTGAAGC	0.408			NA											5	12					0	0	0.001984	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885761	88885761	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:88885761C>A	uc003ydz.2	-	1	536	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	147										ovary(1)	1						GCAAGTCCCACGAAGCACAGC	0.542			NA											20	45					5.35047e-06	6.01183e-06	0.00333	1	0
SLC26A7	115111	broad.mit.edu	37	8	92346636	92346636	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:92346636A>T	uc003yex.2	+	7	1034	c.756A>T	c.(754-756)AAA>AAT	p.K252N	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.K252N|SLC26A7_uc003yfa.2_Missense_Mutation_p.K252N	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	252	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AACAGTTTAAAAGGAAAATTA	0.353			NA											5	19					0	0	0.001168	0	0
GEM	2669	broad.mit.edu	37	8	95264412	95264412	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:95264412C>A	uc003ygj.2	-	4	697	c.448G>T	c.(448-450)GGG>TGG	p.G150W	GEM_uc003ygi.2_Missense_Mutation_p.G150W	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	150					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TATGCGTCCCCGACCTGCATG	0.517	GBM(125;80 1653 28655 32188 47338)|Esophageal Squamous(19;97 579 13602 49091 51766)		NA											24	55					2.48779e-11	3.1456e-11	0.005443	1	0
ESRP1	54845	broad.mit.edu	37	8	95690505	95690505	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:95690505T>C	uc003ygq.3	+	13	1909	c.1726T>C	c.(1726-1728)TCT>CCT	p.S576P	ESRP1_uc003ygr.3_Missense_Mutation_p.S572P|ESRP1_uc003ygs.3_Missense_Mutation_p.S572P|ESRP1_uc003ygt.3_Missense_Mutation_p.S576P|ESRP1_uc003ygu.3_Missense_Mutation_p.S572P|ESRP1_uc003ygv.2_Missense_Mutation_p.S416P|ESRP1_uc003ygw.2_Missense_Mutation_p.S416P	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	576					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TTACCAGCCCTCTGTGATTTT	0.502			NA											15	28					0	0	0.006122	0	0
RIMS2	9699	broad.mit.edu	37	8	105001560	105001560	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:105001560G>T	uc003yls.2	+	15	2530	c.2289G>T	c.(2287-2289)GGG>GGT	p.G763G	RIMS2_uc003ylp.2_Silent_p.G985G|RIMS2_uc003ylw.2_Silent_p.G777G|RIMS2_uc003ylq.2_Silent_p.G777G|RIMS2_uc003ylr.2_Silent_p.G824G	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1047					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCTTCGAGGGACCCGCACTA	0.388			NA								HNSCC(12;0.0054)			34	94					4.92203e-23	7.26071e-23	0.00623	1	0
ZFPM2	23414	broad.mit.edu	37	8	106811019	106811019	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:106811019G>T	uc003ymd.2	+	7	830	c.807G>T	c.(805-807)TTG>TTT	p.L269F	ZFPM2_uc011lhs.1_5'UTR|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	269	C2HC-type 1.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGGCCCATTTGATGTACTACT	0.507			NA											10	26					4.68919e-08	5.51444e-08	0.008291	1	0
ANGPT1	284	broad.mit.edu	37	8	108306254	108306254	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:108306254A>T	uc003ymn.2	-	6	1416	c.948T>A	c.(946-948)AAT>AAA	p.N316K	ANGPT1_uc011lhv.1_Missense_Mutation_p.N116K|ANGPT1_uc003ymo.2_Missense_Mutation_p.N315K|ANGPT1_uc003ymp.3_Missense_Mutation_p.N115K	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	316	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGACATCCATATTGCAAAACA	0.348			NA											29	63					0	0	0.004289	0	0
CSMD3	114788	broad.mit.edu	37	8	114031388	114031388	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:114031388G>C	uc003ynu.2	-	6	1097	c.938C>G	c.(937-939)CCA>CGA	p.P313R	CSMD3_uc003ynt.2_Missense_Mutation_p.P273R|CSMD3_uc011lhx.1_Missense_Mutation_p.P313R|CSMD3_uc010mcx.1_Missense_Mutation_p.P313R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	313	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTGGTGGTGGTATATTCAT	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	62					0	0	0.00333	0	0
TRPS1	7227	broad.mit.edu	37	8	116616280	116616280	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:116616280A>C	uc003ynz.2	-	3	2336	c.1877T>G	c.(1876-1878)GTA>GGA	p.V626G	TRPS1_uc011lhy.1_Missense_Mutation_p.V630G|TRPS1_uc003yny.2_Missense_Mutation_p.V639G|TRPS1_uc010mcy.2_Missense_Mutation_p.V626G	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	626	C2H2-type 3; atypical.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAGTACATCTACGTCAGGGGT	0.517			NA							Langer-Giedion_syndrome				10	24					0	0	0.001368	0	0
ATAD2	29028	broad.mit.edu	37	8	124349935	124349935	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:124349935C>A	uc003yqh.3	-	21	3089	c.2981G>T	c.(2980-2982)AGA>ATA	p.R994I	ATAD2_uc011lii.1_Missense_Mutation_p.R785I|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	994	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGTAACATTTCTTAAGAAAAT	0.398			NA											13	37					0.000151284	0.000164489	0.001855	1	0
TMEM71	137835	broad.mit.edu	37	8	133734362	133734362	+	Splice_Site	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:133734362C>T	uc003ytp.2	-	7	903	c.674_splice	c.e7-1	p.E225_splice	TMEM71_uc003ytm.1_Splice_Site_p.E47_splice|TMEM71_uc003ytn.2_Splice_Site_p.E207_splice|TMEM71_uc003yto.2_Splice_Site_p.E163_splice	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1							integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AACCTGGTTTCTAATAGGAAG	0.353			NA											20	53					0	0	0.00333	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136554930	136554930	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:136554930G>C	uc003yuv.2	+	3	635	c.241G>C	c.(241-243)GGC>CGC	p.G81R	KHDRBS3_uc003yuw.2_Missense_Mutation_p.G81R	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	81	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			GGGTCCACGTGGCAATTCTCT	0.353			NA											21	46					0	0	0.005443	0	0
FAM135B	51059	broad.mit.edu	37	8	139144932	139144932	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:139144932G>C	uc003yuy.2	-	20	4296	c.4125C>G	c.(4123-4125)AAC>AAG	p.N1375K	FAM135B_uc003yux.2_Missense_Mutation_p.N1276K|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1375										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGATCAGGGTGTTGGCAGTGT	0.532			NA								HNSCC(54;0.14)			50	164					0	0	0.00361	0	0
EIF2C2	27161	broad.mit.edu	37	8	141549469	141549469	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:141549469C>T	uc003yvn.2	-	16	2159	c.2119G>A	c.(2119-2121)GTG>ATG	p.V707M	EIF2C2_uc010men.2_Missense_Mutation_p.V630M|EIF2C2_uc010meo.2_Missense_Mutation_p.V707M	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	707	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CTCTTCTGCACCACGATGAAG	0.597			NA											13	43					0	0	0.001368	0	0
PSCA	8000	broad.mit.edu	37	8	143763484	143763484	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:143763484G>T	uc003ywu.2	+	3	361	c.306G>T	c.(304-306)CCG>CCT	p.P102P	uc003ywt.1_5'Flank	NM_005672	NP_005663	O43653	PSCA_HUMAN	prostate stem cell antigen preproprotein	93											0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CCCTGCAGCCGGCTGCTGCCA	0.662			NA											14	27					2.4624e-09	2.99344e-09	0.008871	1	0
SCRIB	23513	broad.mit.edu	37	8	144895510	144895510	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:144895510C>G	uc003yzp.1	-	6	545	c.538G>C	c.(538-540)GAT>CAT	p.D180H	SCRIB_uc003yzo.1_Missense_Mutation_p.D180H|MIR937_hsa-mir-937|MI0005759_5'Flank	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	180	LRR 7.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCTCCCAGATCCAGCTGTTCC	0.652	Pancreas(51;966 1133 10533 14576 29674)		NA											19	59					0	0	0.004656	0	0
DMRT1	1761	broad.mit.edu	37	9	968083	968083	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:968083C>A	uc003zgv.2	+	5	1215	c.1066C>A	c.(1066-1068)CCT>ACT	p.P356T		NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	356					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		TGAATGTGAGCCTGCGTCGGA	0.557			NA											27	55					1.08312e-15	1.46694e-15	0.009535	1	0
DMRT3	58524	broad.mit.edu	37	9	990658	990658	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:990658C>G	uc003zgw.1	+	2	1110	c.1072C>G	c.(1072-1074)CTG>GTG	p.L358V		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	358					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GGCTGGGCCTCTGCAGCCCCC	0.582			NA											29	21					0	0	0.002445	0	0
RCL1	10171	broad.mit.edu	37	9	4844632	4844632	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:4844632A>C	uc003zis.2	+	7	1076	c.818A>C	c.(817-819)GAG>GCG	p.E273A	RCL1_uc003zit.2_Missense_Mutation_p.E115A|RCL1_uc010mhk.1_Missense_Mutation_p.E115A|RCL1_uc010mhl.1_Missense_Mutation_p.E87A	NM_005772	NP_005763	Q9Y2P8	RCL1_HUMAN	RNA terminal phosphate cyclase-like 1	273					ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)		GTACTTCCAGAGGACCTTGGC	0.572			NA											49	142					0	0	0.00361	0	0
JAK2	3717	broad.mit.edu	37	9	5029897	5029897	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:5029897A>G	uc010mhm.2	+	3	454	c.341A>G	c.(340-342)TAC>TGC	p.Y114C	JAK2_uc003ziw.2_Missense_Mutation_p.Y114C	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	114	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		AATGTACTCTACAGAATAAGG	0.328			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				24	157					0	0	0.002096	0	0
KDM4C	23081	broad.mit.edu	37	9	6888033	6888033	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:6888033A>G	uc003zkh.2	+	7	1333	c.753A>G	c.(751-753)GTA>GTG	p.V251V	KDM4C_uc010mhu.2_Silent_p.V273V|KDM4C_uc010mhw.2_Silent_p.V251V|KDM4C_uc011lmi.1_Silent_p.V251V|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.V251V|KDM4C_uc011lmk.1_Silent_p.V70V	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	251	JmjC.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CTCCATCAGTATTGAAGAAAT	0.333			NA											93	50					0	0	0.00361	0	0
DDX58	23586	broad.mit.edu	37	9	32480281	32480281	+	Silent	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:32480281G>A	uc003zra.2	-	12	1868	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.F525F|DDX58_uc011lnr.1_Silent_p.F367F|DDX58_uc010mji.2_Silent_p.F499F	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	570					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CATTGCTGAAGAAGTCTTTCA	0.413			NA											13	113					0	0	0.004007	0	0
TAF1L	138474	broad.mit.edu	37	9	32630650	32630650	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:32630650G>C	uc003zrg.1	-	1	5018	c.4928C>G	c.(4927-4929)GCA>GGA	p.A1643G	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1643					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTCCAAAGCTGCTTCTTTAGC	0.443			NA											116	38					0	0	0.00361	0	0
NOL6	65083	broad.mit.edu	37	9	33465774	33465774	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:33465774C>G	uc003zsz.2	-	19	2587	c.2486G>C	c.(2485-2487)AGA>ACA	p.R829T	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Missense_Mutation_p.R826T|NOL6_uc011lob.1_Missense_Mutation_p.R777T|NOL6_uc003ztb.1_Missense_Mutation_p.R829T	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	829					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CCTTGTGTCTCTCTCAAGGCG	0.632			NA											3	29					0	0	0.009096	0	0
CCIN	881	broad.mit.edu	37	9	36170694	36170694	+	Missense_Mutation	SNP	C	C	G	rs142836285	by1000genomes	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:36170694C>G	uc003zzb.3	+	1	1306	c.1195C>G	c.(1195-1197)CGG>GGG	p.R399G		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	399	Kelch 3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CTATGATGAGCGGAAGGAAGT	0.557			NA											74	31					0	0	0.00361	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745949	37745949	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:37745949C>A	uc004aag.1	+	16	3964	c.3920C>A	c.(3919-3921)TCT>TAT	p.S1307Y	FRMPD1_uc004aah.1_Missense_Mutation_p.S1307Y	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1307						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CCTGAAGTCTCTGCCAGTCTC	0.507			NA											6	35					0.00116845	0.00123451	0.001168	1	0
Unknown	0	broad.mit.edu	37	9	69067929	69067929	+	Splice_Site	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:69067929G>A	uc004afe.1	+	3		c.744_splice	c.e3+1		uc010mnq.1_Splice_Site					Homo sapiens cDNA, FLJ18209.												NA						TGATATGTTGGTGAGTCAGTT	0.209			NA											5	2					0	0	0.00308	0	0
TRPM6	140803	broad.mit.edu	37	9	77354675	77354675	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:77354675G>C	uc004ajl.1	-	34	5689	c.5451C>G	c.(5449-5451)ATC>ATG	p.I1817M	TRPM6_uc004ajk.1_Missense_Mutation_p.I1812M|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.I768M|TRPM6_uc010mpd.1_Missense_Mutation_p.I650M|TRPM6_uc010mpe.1_Missense_Mutation_p.I364M|TRPM6_uc004ajj.1_Missense_Mutation_p.I773M	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1817	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TCTCCTGGAAGATTTTATGCC	0.483			NA											16	111					0	0	0.006122	0	0
SHC3	53358	broad.mit.edu	37	9	91661855	91661855	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:91661855G>T	uc004aqg.2	-	8	1324	c.1017C>A	c.(1015-1017)CAC>CAA	p.H339Q		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	339	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TGTAGTATGGGTGGTCTGAGC	0.507			NA											47	18					1.08114e-33	1.68085e-33	0.00361	1	0
HEMGN	55363	broad.mit.edu	37	9	100692953	100692953	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:100692953G>A	uc004axy.2	-	3	832	c.724C>T	c.(724-726)CTT>TTT	p.L242F	HEMGN_uc004axz.2_Missense_Mutation_p.L242F	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	242					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GGACAAGGAAGGATTTTGGGT	0.423			NA											105	81					0	0	0.00361	0	0
C9orf125	84302	broad.mit.edu	37	9	104238469	104238469	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:104238469C>G	uc004bbm.2	-	2	1228	c.906G>C	c.(904-906)ATG>ATC	p.M302I	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	302	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				CCACCAGACCCATGCTATACA	0.567			NA											55	42					0	0	0.00361	0	0
COL27A1	85301	broad.mit.edu	37	9	116930095	116930095	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:116930095G>T	uc011lxl.1	+	3	260	c.260G>T	c.(259-261)GGC>GTC	p.G87V	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_5'UTR	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	87	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCTCCCACGGGCACCGTCATT	0.667			NA											67	34					9.2564e-22	1.34772e-21	0.00361	1	0
C9orf91	203197	broad.mit.edu	37	9	117405509	117405509	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:117405509G>T	uc004bjd.3	+	9	1162	c.945G>T	c.(943-945)ACG>ACT	p.T315T	C9orf91_uc004bje.3_Silent_p.T294T|C9orf91_uc004bjf.3_Silent_p.T214T	NM_153045	NP_694590	Q5VZI3	CI091_HUMAN	hypothetical protein LOC203197	315						integral to membrane				pancreas(1)	1						CACGACACACGAACTCTCCGA	0.587			NA											60	32					3.86002e-21	5.57988e-21	0.00361	1	0
ASTN2	23245	broad.mit.edu	37	9	119203026	119203026	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:119203026C>G	uc004bjs.1	-	22	3745	c.3644G>C	c.(3643-3645)GGA>GCA	p.G1215A	ASTN2_uc004bjr.1_Missense_Mutation_p.G1211A|ASTN2_uc004bjt.1_Missense_Mutation_p.G1164A|ASTN2_uc004bjp.1_Missense_Mutation_p.G308A|ASTN2_uc004bjq.1_Missense_Mutation_p.G267A|ASTN2_uc011lxr.1_Missense_Mutation_p.G267A|ASTN2_uc011lxs.1_Missense_Mutation_p.G267A|ASTN2_uc011lxt.1_Missense_Mutation_p.G267A|ASTN2_uc004bjo.1_5'UTR	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1215	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTGCTCCTTTCCACTTGTGTA	0.473			NA											8	91					0	0	0.008291	0	0
LHX6	26468	broad.mit.edu	37	9	124979357	124979357	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:124979357G>T	uc010mvw.2	-	4	694	c.585C>A	c.(583-585)GCC>GCA	p.A195A	LHX6_uc004blx.3_Silent_p.A224A|LHX6_uc004bly.3_Silent_p.A224A	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	195					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGTTCTCGGCGGCCCTCTTGA	0.647			NA											43	33					1.0442e-30	1.59878e-30	0.00361	1	0
ZBTB26	57684	broad.mit.edu	37	9	125681796	125681796	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:125681796C>T	uc004bnj.2	-	2	630	c.418G>A	c.(418-420)GAA>AAA	p.E140K	ZBTB26_uc004bnk.2_Missense_Mutation_p.E140K	NM_020924	NP_065975	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCTGTGGTTCACATCCCTCT	0.468			NA											16	50					0	0	0.00499	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134471693	134471693	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:134471693T>C	uc004cbc.2	-	14	2253	c.2123A>G	c.(2122-2124)GAC>GGC	p.D708G	RAPGEF1_uc004cbb.2_Missense_Mutation_p.D726G|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Missense_Mutation_p.D883G|RAPGEF1_uc004cbd.2_Missense_Mutation_p.D713G	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	708	N-terminal Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		ACCTTTCCTGTCAGTCTCAGT	0.607			NA											13	49					0	0	0.001855	0	0
NTNG2	84628	broad.mit.edu	37	9	135114648	135114648	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:135114648C>T	uc004cbh.2	+	6	1988	c.1212C>T	c.(1210-1212)AAC>AAT	p.N404N		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	404	Laminin EGF-like 2.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		ATGATGAGAACGTCTGCATTG	0.632			NA											6	46					0	0	0.001984	0	0
DBH	1621	broad.mit.edu	37	9	136521726	136521726	+	Missense_Mutation	SNP	G	G	T	rs148439785	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:136521726G>T	uc004cel.2	+	10	1525	c.1516G>T	c.(1516-1518)GCT>TCT	p.A506S	uc010nao.1_Intron	NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	506	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CTGCAAGAGCGCTGTGGACGC	0.612			NA											4	38					0.00024832	0.00026826	0.009096	1	0
KCNT1	57582	broad.mit.edu	37	9	138669354	138669354	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:138669354C>T	uc011mdq.1	+	21	2594	c.2520C>T	c.(2518-2520)AAC>AAT	p.N840N	KCNT1_uc011mdr.1_Silent_p.N667N|KCNT1_uc010nbf.2_Silent_p.N795N|KCNT1_uc004cgo.1_Silent_p.N589N	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	840						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TGCTGGACAACAAGTGAGGCT	0.657			NA											20	14					0	0	0.002299	0	0
CACNA1B	774	broad.mit.edu	37	9	140772602	140772602	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:140772602C>A	uc004cog.2	+	1	362	c.217C>A	c.(217-219)CGC>AGC	p.R73S	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	73	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CACCGTCAACCGCTCGCTCTT	0.537			NA											8	25					1.58986e-06	1.8065e-06	0.008291	1	0
P2RY8	286530	broad.mit.edu	37	X	1584597	1584597	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:1584597G>T	uc004cpz.2	-	2	1103	c.855C>A	c.(853-855)AAC>AAA	p.N285K		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	285	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCAGACAGTTGTTGAGGCAGC	0.582			NA	T	CRLF2	B-ALL|Downs associated ALL								37	51					2.77807e-22	4.08016e-22	0.003214	1	0
MXRA5	25878	broad.mit.edu	37	X	3228409	3228409	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:3228409C>A	uc004crg.3	-	7	7992	c.7835G>T	c.(7834-7836)GGG>GTG	p.G2612V		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2612	Ig-like C2-type 10.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCGGTAGGCCCCGGCGTCCAC	0.612			NA											3	25					0.004672	0.00489009	0.004672	1	0
MXRA5	25878	broad.mit.edu	37	X	3238246	3238246	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:3238246C>A	uc004crg.3	-	5	5637	c.5480G>T	c.(5479-5481)GGA>GTA	p.G1827V		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1827						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGGAAGCTTCCTGAGGACTG	0.488			NA											8	30					1.08611e-07	1.26254e-07	0.000978	1	0
NLGN4X	57502	broad.mit.edu	37	X	5827152	5827152	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:5827152C>A	uc010ndh.2	-	4	1255	c.754G>T	c.(754-756)GGC>TGC	p.G252C	NLGN4X_uc004crp.2_Missense_Mutation_p.G272C|NLGN4X_uc004crq.2_Missense_Mutation_p.G252C|NLGN4X_uc010ndi.2_Missense_Mutation_p.G289C|NLGN4X_uc004crr.2_Missense_Mutation_p.G252C|NLGN4X_uc010ndj.2_Missense_Mutation_p.G252C	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	252	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GCCCCCGAGCCAAAGATGGTC	0.577			NA											5	47					0.00307968	0.00323014	0.00308	1	0
MID1	4281	broad.mit.edu	37	X	10423046	10423046	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:10423046C>G	uc004cte.3	-	9	1710	c.1519G>C	c.(1519-1521)GAA>CAA	p.E507Q	MID1_uc004ctd.3_Missense_Mutation_p.E218Q|MID1_uc004ctg.3_Missense_Mutation_p.E507Q|MID1_uc004cth.3_Missense_Mutation_p.E469Q|MID1_uc004ctk.3_Missense_Mutation_p.E507Q|MID1_uc004cti.3_Missense_Mutation_p.E507Q|MID1_uc004ctj.3_Missense_Mutation_p.E507Q|MID1_uc011mie.1_RNA|MID1_uc004csz.3_Missense_Mutation_p.E179Q|MID1_uc004cta.3_Missense_Mutation_p.E263Q|MID1_uc004ctb.3_Missense_Mutation_p.E167Q|MID1_uc004ctc.3_Missense_Mutation_p.E274Q	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	507	B30.2/SPRY.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						TCATCACGTTCTACTGTCAAG	0.438			NA											28	52					0	0	0.003271	0	0
MID1	4281	broad.mit.edu	37	X	10442753	10442753	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:10442753G>T	uc004cte.3	-	6	1242	c.1051C>A	c.(1051-1053)CCT>ACT	p.P351T	MID1_uc004ctd.3_Missense_Mutation_p.P62T|MID1_uc004ctg.3_Missense_Mutation_p.P351T|MID1_uc004cth.3_Missense_Mutation_p.P313T|MID1_uc004ctk.3_Missense_Mutation_p.P351T|MID1_uc004cti.3_Missense_Mutation_p.P351T|MID1_uc004ctj.3_Missense_Mutation_p.P351T|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Missense_Mutation_p.P402T|MID1_uc004ctn.1_Missense_Mutation_p.P351T|MID1_uc004cto.1_Missense_Mutation_p.P313T|MID1_uc010ndw.1_Missense_Mutation_p.P62T|MID1_uc004cts.1_Missense_Mutation_p.P118T|MID1_uc004csz.3_Missense_Mutation_p.P23T|MID1_uc004cta.3_Missense_Mutation_p.P107T|MID1_uc004ctb.3_Missense_Mutation_p.P11T|MID1_uc004ctc.3_Missense_Mutation_p.P118T|MID1_uc004ctl.1_Missense_Mutation_p.P107T|MID1_uc004ctp.1_RNA|MID1_uc004ctq.1_Missense_Mutation_p.P118T|MID1_uc004ctr.1_Missense_Mutation_p.P118T|MID1_uc010ndu.1_Missense_Mutation_p.P118T|MID1_uc010ndv.1_Missense_Mutation_p.P62T	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	351	COS.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						TTGATTTCAGGAATTAGAACC	0.393			NA											20	71					1.9806e-07	2.29177e-07	0.002299	1	0
GLRA2	2742	broad.mit.edu	37	X	14599452	14599452	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:14599452G>T	uc010nep.2	+	5	750	c.418G>T	c.(418-420)GCC>TCC	p.A140S	GLRA2_uc010neq.2_Missense_Mutation_p.A140S|GLRA2_uc004cwe.3_Missense_Mutation_p.A140S|GLRA2_uc011mio.1_Missense_Mutation_p.A51S|GLRA2_uc011mip.1_Missense_Mutation_p.A118S	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	140	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TGAGAAGGGTGCCAACTTCCA	0.483			NA											49	56					4.09106e-26	6.16102e-26	0.00361	1	0
ACE2	59272	broad.mit.edu	37	X	15599456	15599456	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:15599456G>A	uc004cxa.1	-	8	1126	c.958C>T	c.(958-960)CTT>TTT	p.L320F	ACE2_uc004cxb.2_Missense_Mutation_p.L320F	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	320	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	ATATTAGGAAGACCAACAGAT	0.458			NA											28	97					0	0	0.002445	0	0
PTCHD1	139411	broad.mit.edu	37	X	23398254	23398254	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:23398254G>T	uc004dal.3	+	2	906	c.898G>T	c.(898-900)GGC>TGC	p.G300C	PTCHD1_uc010nfu.1_Missense_Mutation_p.G300C	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	300	Helical; (Potential).|SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						ACCCTGGCTAGGCCTGCTCGG	0.547			NA											25	92					3.73988e-18	5.26296e-18	0.00632	1	0
POLA1	5422	broad.mit.edu	37	X	24735405	24735405	+	Splice_Site	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:24735405A>T	uc004dbl.2	+	9	712	c.689_splice	c.e9-2	p.G230_splice	POLA1_uc004dbm.2_Splice_Site_p.G236_splice|POLA1_uc004dbn.2_Splice_Site_p.G94_splice	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1						cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	TGATGCCTACAGGCGATGATG	0.358			NA											10	46					0	0	0.00245	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938085	29938085	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:29938085G>A	uc004dby.2	+	8	1439	c.931G>A	c.(931-933)GGG>AGG	p.G311R		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	311	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GGAGCATCTTGGGGAACAGGA	0.368			NA											15	71					0	0	0.008871	0	0
DMD	1756	broad.mit.edu	37	X	31196064	31196064	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:31196064C>A	uc004dda.1	-	71	10491	c.10247G>T	c.(10246-10248)TGG>TTG	p.W3416L	DMD_uc004dcq.1_Missense_Mutation_p.W687L|DMD_uc004dcr.1_Intron|DMD_uc004dcs.1_Intron|DMD_uc004dct.1_Missense_Mutation_p.W956L|DMD_uc004dcu.1_Missense_Mutation_p.W956L|DMD_uc004dcv.1_Intron|DMD_uc004dcw.2_Missense_Mutation_p.W2072L|DMD_uc004dcx.2_Missense_Mutation_p.W2075L|DMD_uc004dcz.2_Missense_Mutation_p.W3293L|DMD_uc004dcy.1_Missense_Mutation_p.W3412L|DMD_uc004ddb.1_Missense_Mutation_p.W3408L|DMD_uc004dcm.1_Missense_Mutation_p.W348L|DMD_uc004dcn.1_Intron|DMD_uc004dco.1_Missense_Mutation_p.W348L|DMD_uc004dcp.1_Intron|DMD_uc011mkb.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3416					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATCTACTGGCCAGAAGTTGAT	0.413			NA											6	26					3.09899e-07	3.55731e-07	0.004482	1	0
DMD	1756	broad.mit.edu	37	X	31496470	31496470	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:31496470G>T	uc004dda.1	-	59	8934	c.8690C>A	c.(8689-8691)GCC>GAC	p.A2897D	DMD_uc004dcq.1_Missense_Mutation_p.A168D|DMD_uc004dcr.1_Missense_Mutation_p.A437D|DMD_uc004dcs.1_Missense_Mutation_p.A437D|DMD_uc004dct.1_Missense_Mutation_p.A437D|DMD_uc004dcu.1_Missense_Mutation_p.A437D|DMD_uc004dcv.1_Missense_Mutation_p.A437D|DMD_uc004dcw.2_Missense_Mutation_p.A1553D|DMD_uc004dcx.2_Missense_Mutation_p.A1556D|DMD_uc004dcz.2_Missense_Mutation_p.A2774D|DMD_uc004dcy.1_Missense_Mutation_p.A2893D|DMD_uc004ddb.1_Missense_Mutation_p.A2889D	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2897	Spectrin 20.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GACATTCTGGGCTCTCTCCTC	0.433			NA											13	57					1.45105e-14	1.9341e-14	0.006122	1	0
DMD	1756	broad.mit.edu	37	X	32490297	32490297	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:32490297C>A	uc004dda.1	-	22	3177	c.2933G>T	c.(2932-2934)AGA>ATA	p.R978I	DMD_uc004dcz.2_Missense_Mutation_p.R855I|DMD_uc004dcy.1_Missense_Mutation_p.R974I|DMD_uc004ddb.1_Missense_Mutation_p.R970I|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	978	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCCCCGAGTCTCTGCTCCAT	0.403			NA											24	114					3.73808e-20	5.36518e-20	0.005443	1	0
DMD	1756	broad.mit.edu	37	X	32591661	32591661	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:32591661G>T	uc004dda.1	-	15	2042	c.1798C>A	c.(1798-1800)CTT>ATT	p.L600I	DMD_uc004dcz.2_Missense_Mutation_p.L477I|DMD_uc004dcy.1_Missense_Mutation_p.L596I|DMD_uc004ddb.1_Missense_Mutation_p.L592I|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.L592I|DMD_uc010ngp.1_3'UTR|DMD_uc010ngq.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	600	Spectrin 3.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGTTTTTGAAGACTTGATAAC	0.338			NA											24	36					9.39395e-14	1.24064e-13	0.00632	1	0
FAM47C	442444	broad.mit.edu	37	X	37028281	37028281	+	Nonsense_Mutation	SNP	G	G	T	rs145080907	byFrequency	TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:37028281G>T	uc004ddl.1	+	1	1812	c.1798G>T	c.(1798-1800)GAG>TAG	p.E600*		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	600										ovary(3)	3						GGAGCCCCCCGAGACTGGAGT	0.647			NA											28	35					9.8876e-21	1.42117e-20	0.004878	1	0
XK	7504	broad.mit.edu	37	X	37587552	37587552	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:37587552G>T	uc004ddq.2	+	3	1254	c.1172G>T	c.(1171-1173)TGG>TTG	p.W391L		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	391	Cytoplasmic (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				TTTCAGAGGTGGCTCAGGTGT	0.473			NA											25	23					2.79863e-10	3.46481e-10	0.004656	1	0
SYTL5	94122	broad.mit.edu	37	X	37961679	37961680	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:37961679_37961680CT>AA	uc004ddu.2	+	11	1681_1682	c.1147_1148CT>AA	c.(1147-1149)CTA>AAA	p.L383K	SYTL5_uc004ddv.2_Missense_Mutation_p.L383K|SYTL5_uc004ddx.2_Missense_Mutation_p.L383K	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	383					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						GGCAAGTGGCCTATCAACTGTA	0.406			NA											5	64					0	0	0.004672	0	0
OTC	5009	broad.mit.edu	37	X	38262994	38262994	+	Splice_Site	SNP	G	G	T	rs68170503		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:38262994G>T	uc004def.3	+	6	877	c.663_splice	c.e6+1	p.K221_splice		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor						arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	TACTCCAAAGGTAGGGAAACT	0.453			NA											17	54					8.00594e-06	8.95565e-06	0.007413	1	0
MAOB	4129	broad.mit.edu	37	X	43626797	43626797	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:43626797G>C	uc004dfz.3	-	15	1655	c.1479C>G	c.(1477-1479)CTC>CTG	p.L493L	MAOB_uc011mkx.1_3'UTR|MAOB_uc011mky.1_Silent_p.L477L	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	493	Helical; Anchor for type IV membrane protein.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CAATCAGCCTGAGCAGGCCTG	0.522			NA											25	43					0	0	0.009535	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49032082	49032082	+	Silent	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:49032082G>C	uc004dmy.1	-	9	1814	c.1788C>G	c.(1786-1788)CCC>CCG	p.P596P	PRICKLE3_uc011mmv.1_Silent_p.P528P|PRICKLE3_uc011mmw.1_Silent_p.P515P|PRICKLE3_uc011mmx.1_Silent_p.P558P	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	596							protein binding|zinc ion binding			breast(1)	1						GAGAGTCCCTGGGGAGCGATA	0.612			NA											8	51					0	0	0.006214	0	0
PAGE1	8712	broad.mit.edu	37	X	49454072	49454072	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:49454072C>T	uc004dom.2	-	5	500	c.367G>A	c.(367-369)GTC>ATC	p.V123I		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	123					cellular defense response					skin(1)	1	Ovarian(276;0.236)					AACTCCTGGACATCAGGACCA	0.483			NA											34	148					0	0	0.005524	0	0
HUWE1	10075	broad.mit.edu	37	X	53617988	53617988	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:53617988G>T	uc004dsp.2	-	34	4469	c.4067C>A	c.(4066-4068)CCT>CAT	p.P1356H	HUWE1_uc004dsn.2_Missense_Mutation_p.P181H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1356					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GATTGGAGGAGGGTGGGTTAA	0.483			NA											16	63					5.3912e-06	6.05086e-06	0.006122	1	0
HUWE1	10075	broad.mit.edu	37	X	53672342	53672342	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:53672342C>G	uc004dsp.2	-	7	827	c.425G>C	c.(424-426)AGC>ACC	p.S142T		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	142					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGATCTTTTGCTAAATACATA	0.453			NA											7	67					0	0	0.006214	0	0
APEX2	27301	broad.mit.edu	37	X	55033271	55033271	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:55033271G>C	uc004dtz.2	+	6	1036	c.960G>C	c.(958-960)CAG>CAC	p.Q320H	APEX2_uc011mom.1_Missense_Mutation_p.Q149H	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	320					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						CTGCAAAACAGTGCCCACCTC	0.567			NA						Other_BER_factors					6	41					0	0	0.001168	0	0
ALAS2	212	broad.mit.edu	37	X	55047622	55047622	+	Silent	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:55047622A>T	uc004dua.3	-	5	639	c.501T>A	c.(499-501)ACT>ACA	p.T167T	ALAS2_uc004dub.3_Silent_p.T154T|ALAS2_uc004dud.3_Silent_p.T130T	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	167					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	AGCGGTTCACAGTCTTGAACA	0.473			NA											33	82					0	0	0.005524	0	0
FAM104B	90736	broad.mit.edu	37	X	55185586	55185586	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:55185586G>T	uc004duh.1	-	2	116	c.96C>A	c.(94-96)ATC>ATA	p.I32I	FAM104B_uc004dug.1_Silent_p.I32I|FAM104B_uc004dui.3_Silent_p.I32I	NM_138362	NP_612371	Q5XKR9	F104B_HUMAN	hypothetical protein LOC90736	32											0						AATCCTGAAAGATAGGGTTTC	0.378			NA											26	45					4.22769e-11	5.32552e-11	0.00632	1	0
RRAGB	10325	broad.mit.edu	37	X	55784772	55784772	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:55784772G>C	uc004dup.2	+	11	1772	c.1121G>C	c.(1120-1122)CGC>CCC	p.R374P	RRAGB_uc004duq.2_Missense_Mutation_p.R346P	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	374					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						CTTCTCATGCGCTAAACATTG	0.383			NA											7	34					0	0	0.001984	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722499	64722499	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:64722499A>T	uc010nko.2	+	5	1897	c.1888A>T	c.(1888-1890)AGC>TGC	p.S630C		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	630							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						ACGAGTGCAGAGCTATGGCCC	0.537			NA											4	14					0	0	0.000602	0	0
HEPH	9843	broad.mit.edu	37	X	65418786	65418786	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:65418786A>T	uc011moz.1	+	11	1849	c.1789A>T	c.(1789-1791)AAT>TAT	p.N597Y	HEPH_uc004dwn.2_Missense_Mutation_p.N597Y|HEPH_uc004dwo.2_Missense_Mutation_p.N327Y|HEPH_uc010nkr.2_Intron|HEPH_uc011mpa.1_Missense_Mutation_p.N597Y	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	594	Plastocyanin-like 4.|Extracellular (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CTGGTACAGCAATGCCAATCA	0.448			NA											15	61					0	0	0.003163	0	0
EDA	1896	broad.mit.edu	37	X	68836455	68836455	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:68836455C>A	uc004dxs.2	+	1	545	c.303C>A	c.(301-303)CCC>CCA	p.P101P	EDA_uc004dxr.2_Silent_p.P101P|EDA_uc011mpj.1_Silent_p.P101P|EDA_uc004dxn.1_Silent_p.P101P|EDA_uc004dxm.1_Silent_p.P101P|EDA_uc004dxp.1_Silent_p.P101P|EDA_uc004dxq.1_Silent_p.P101P|EDA_uc004dxl.1_Silent_p.P101P	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	101	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						CTGACAGCCCCATCACCAGTC	0.677			NA											20	37					1.87028e-06	2.12035e-06	0.001882	1	0
KIF4A	24137	broad.mit.edu	37	X	69623835	69623835	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:69623835C>A	uc004dyg.2	+	24	2868	c.2741C>A	c.(2740-2742)ACA>AAA	p.T914K	KIF4A_uc010nkw.2_Missense_Mutation_p.T914K	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	914	Potential.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						GAGATAGAGACAGAGTTACAA	0.448			NA											12	55					3.27435e-08	3.86864e-08	0.00245	1	0
SLC7A3	84889	broad.mit.edu	37	X	70147815	70147815	+	Silent	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:70147815C>G	uc004dyn.2	-	6	1034	c.876G>C	c.(874-876)CTG>CTC	p.L292L	SLC7A3_uc004dyo.2_Silent_p.L292L	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	292	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGCAGACAGACAGTGAGATCA	0.517			NA											10	47					0	0	0.00245	0	0
ACRC	93953	broad.mit.edu	37	X	70824337	70824337	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:70824337G>C	uc004eae.2	+	8	1711	c.1210G>C	c.(1210-1212)GCA>CCA	p.A404P	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	404						nucleus				ovary(3)	3	Renal(35;0.156)					GGAAGAGCCTGCACCTGTGGT	0.478			NA											4	5					0	0	0.001168	0	0
RGAG4	340526	broad.mit.edu	37	X	71351063	71351064	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:71351063_71351064CC>AA	uc010nlh.1	-	1	688_689	c.327_328GG>TT	c.(325-330)CAGGAT>CATTAT	p.109_110QD>HY	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	109_110										ovary(2)|skin(1)	3	Renal(35;0.156)					GTGCTGCGATCCTGGATCACGT	0.683			NA											9	8					0	0	0.004672	0	0
SRPX2	27286	broad.mit.edu	37	X	99901370	99901370	+	Silent	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:99901370A>G	uc004egb.2	+	2	531	c.51A>G	c.(49-51)CTA>CTG	p.L17L		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	17					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						TGTTCTTCCTAACTCCGGCAG	0.463			NA											5	94					0	0	0.001168	0	0
ARL13A	392509	broad.mit.edu	37	X	100240690	100240690	+	Silent	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:100240690G>T	uc004ego.2	+	4	281	c.165G>T	c.(163-165)TCG>TCT	p.S55S	ARL13A_uc011mrf.1_Silent_p.S55S|ARL13A_uc010nng.2_Silent_p.S55S	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	55							GTP binding			ovary(1)	1						GCATGAAATCGGAACTGACTA	0.448			NA											3	57					0.004672	0.00489009	0.004672	1	0
HNRNPH2	3188	broad.mit.edu	37	X	100667366	100667366	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:100667366C>G	uc004ehm.2	+	2	560	c.390C>G	c.(388-390)TTC>TTG	p.F130L	HNRNPH2_uc004ehn.2_Missense_Mutation_p.F130L	NM_019597	NP_062543	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2	130	RRM 2.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTGTTCAGTTCTTTTCAGGGT	0.507			NA											21	65					0	0	0.001882	0	0
ESX1	80712	broad.mit.edu	37	X	103494976	103494976	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:103494976C>G	uc004ely.2	-	4	1212	c.1154G>C	c.(1153-1155)GGC>GCC	p.G385A		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	385					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGGAGCCAGGCCAGTGTGAGG	0.582	Pancreas(200;1705 2227 25194 28471 45274)		NA											11	17					0	0	0.00245	0	0
MID2	11043	broad.mit.edu	37	X	107169377	107169377	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:107169377A>T	uc004enl.2	+	9	2224	c.1651A>T	c.(1651-1653)AAT>TAT	p.N551Y	MID2_uc004enk.2_Missense_Mutation_p.N521Y	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	551	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						GAAGATCTCCAATGATGGATT	0.403			NA											45	31					0	0	0.003214	0	0
PSMD10	5716	broad.mit.edu	37	X	107328312	107328312	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:107328312C>A	uc004enp.1	-	5	671	c.573G>T	c.(571-573)CTG>CTT	p.L191L	PSMD10_uc004enq.1_3'UTR	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	191	ANK 6.|Interaction with RELA.|Interaction with RB1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						CTTGGGACACCAGCAGTTTTG	0.443			NA											7	126					3.09899e-07	3.55731e-07	0.004482	1	0
IRS4	8471	broad.mit.edu	37	X	107978597	107978597	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:107978597C>T	uc004eoc.2	-	1	1011	c.978G>A	c.(976-978)GAG>GAA	p.E326E		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	326	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTCTCATCTTCTCCAAAAACA	0.567			NA											28	122					0	0	0.002096	0	0
DOCK11	139818	broad.mit.edu	37	X	117733145	117733145	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:117733145A>T	uc004eqp.2	+	23	2579	c.2516A>T	c.(2515-2517)CAG>CTG	p.Q839L	DOCK11_uc004eqq.2_Missense_Mutation_p.Q605L	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	839	DHR-1.				blood coagulation	cytosol	GTP binding			ovary(3)	3						CAGCTGATTCAGTCAGGCTCG	0.393			NA											22	30					0	0	0.005443	0	0
ODZ1	10178	broad.mit.edu	37	X	123556172	123556172	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:123556172G>T	uc004euj.2	-	23	4464	c.4400C>A	c.(4399-4401)GCC>GAC	p.A1467D	ODZ1_uc011muj.1_Missense_Mutation_p.A1473D|ODZ1_uc010nqy.2_Missense_Mutation_p.A1474D	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1467	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTCAGTGGGGGCACCAGCGAT	0.468			NA											55	41					4.09171e-25	6.1073e-25	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135428925	135428925	+	Silent	SNP	T	T	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:135428925T>C	uc004ezu.1	+	6	3351	c.3060T>C	c.(3058-3060)AAT>AAC	p.N1020N	GPR112_uc010nsb.1_Silent_p.N815N|GPR112_uc010nsc.1_Silent_p.N787N	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1020	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGCCAGTTAATGGCAGTTCTG	0.493			NA											10	152					0	0	0.001855	0	0
GPR112	139378	broad.mit.edu	37	X	135429137	135429137	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:135429137C>T	uc004ezu.1	+	6	3563	c.3272C>T	c.(3271-3273)GCC>GTC	p.A1091V	GPR112_uc010nsb.1_Missense_Mutation_p.A886V|GPR112_uc010nsc.1_Missense_Mutation_p.A858V	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1091	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACTTCAGAGGCCACGGTAATC	0.478			NA											83	70					0	0	0.00361	0	0
ZIC3	7547	broad.mit.edu	37	X	136649620	136649620	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:136649620A>G	uc004fak.2	+	1	1275	c.770A>G	c.(769-771)GAC>GGC	p.D257G		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	257	C2H2-type 1; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAGTGGATCGACGAGGCTCAG	0.622			NA											10	56					0	0	0.001368	0	0
MCF2	4168	broad.mit.edu	37	X	138672050	138672050	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:138672050C>A	uc004fau.2	-	20	2608	c.2314G>T	c.(2314-2316)GAT>TAT	p.D772Y	MCF2_uc004fav.2_Missense_Mutation_p.D788Y|MCF2_uc011mwl.1_Missense_Mutation_p.D749Y|MCF2_uc010nsh.1_Missense_Mutation_p.D772Y|MCF2_uc011mwm.1_Missense_Mutation_p.D733Y|MCF2_uc011mwn.1_Missense_Mutation_p.D917Y|MCF2_uc004faw.2_Missense_Mutation_p.D832Y|MCF2_uc011mwo.1_Missense_Mutation_p.D848Y	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	772	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTGCGGTTATCACCTTTTACA	0.299			NA											26	37					9.17885e-22	1.3403e-21	0.003271	1	0
MAGEC3	139081	broad.mit.edu	37	X	140984910	140984910	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:140984910C>A	uc011mwp.1	+	7	1366	c.1366C>A	c.(1366-1368)CTG>ATG	p.L456M	MAGEC3_uc004fbs.2_Missense_Mutation_p.L158M|MAGEC3_uc010nsj.2_Missense_Mutation_p.L158M	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	456	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTATGCCCTGGATGAAAA	0.483			NA											4	42					0.00909568	0.00941286	0.009096	1	0
MAGEC2	51438	broad.mit.edu	37	X	141291758	141291758	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:141291758C>A	uc004fbu.1	-	3	364	c.16G>T	c.(16-18)GGC>TGC	p.G6C		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	6			G -> C (in a breast cancer sample; somatic mutation).			cytoplasm|nucleus		p.G6C(2)		breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AATGGAACGCCTGGAACGGGA	0.527			NA								HNSCC(46;0.14)			5	82					0.000157383	0.000170569	0.00308	1	0
AFF2	2334	broad.mit.edu	37	X	148037617	148037617	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:148037617G>A	uc004fcp.2	+	11	2521	c.2042G>A	c.(2041-2043)AGG>AAG	p.R681K	AFF2_uc004fcq.2_Missense_Mutation_p.R671K|AFF2_uc004fcr.2_Missense_Mutation_p.R642K|AFF2_uc011mxb.1_Missense_Mutation_p.R646K|AFF2_uc004fcs.2_Missense_Mutation_p.R648K|AFF2_uc011mxc.1_Missense_Mutation_p.R322K	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	681					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGCCCCTAGGAAAGAACCA	0.493			NA											41	26					0	0	0.00361	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935687	151935687	+	Silent	SNP	C	C	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:151935687C>A	uc004fgp.2	-	3	689	c.480G>T	c.(478-480)CTG>CTT	p.L160L		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	160	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAAAGACCAGCTGCAAGG	0.547			NA											34	48					5.8336e-16	7.96496e-16	0.003271	1	0
PNMA5	114824	broad.mit.edu	37	X	152159695	152159695	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:152159695G>A	uc010ntw.2	-	3	787	c.448C>T	c.(448-450)CCG>TCG	p.P150S	PNMA5_uc004fha.3_Missense_Mutation_p.P150S|PNMA5_uc010ntx.2_Missense_Mutation_p.P150S|PNMA5_uc004fgy.3_Missense_Mutation_p.P150S	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	150					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTCTTTCGGAGGCTCTAAA	0.368			NA											8	158					0	0	0.004482	0	0
PLXNA3	55558	broad.mit.edu	37	X	153692505	153692505	+	Silent	SNP	C	C	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:153692505C>T	uc004flm.2	+	8	1850	c.1677C>T	c.(1675-1677)ACC>ACT	p.T559T		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	559	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCAGCTGACCGTCACCCTGC	0.697			NA											10	7					0	0	0.001368	0	0
TMLHE	55217	broad.mit.edu	37	X	154736707	154736707	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chrX:154736707G>T	uc004fnn.2	-	6	1013	c.847C>A	c.(847-849)CAA>AAA	p.Q283K	TMLHE_uc004fno.2_Missense_Mutation_p.Q283K|TMLHE_uc004fnp.3_Missense_Mutation_p.Q283K	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	283					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	GGTGCCTTTTGAAGTACCTGT	0.408			NA											5	98					0.000602214	0.00064368	0.000602	1	0
TAS1R2	80834	broad.mit.edu	37	1	19166744	19166744	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:19166744delC	uc001bba.1	-	6	1870	c.1869delG	c.(1867-1869)GGGfs	p.G623fs		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	623	Helical; Name=2; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCTTGGGCGGCCCCACGTACA	0.607			NA											12	94	---	---	---	---	NA	NA	NA	NA	NA
LRRC7	57554	broad.mit.edu	37	1	70541908	70541908	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:70541908delC	uc001dep.2	+	22	4295	c.4265delC	c.(4264-4266)ACCfs	p.T1422fs	LRRC7_uc009wbg.2_Frame_Shift_Del_p.T706fs|LRRC7_uc001deq.2_Frame_Shift_Del_p.T616fs	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1422						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCACAGGCCACCCGGGGACCT	0.483			NA											31	67	---	---	---	---	NA	NA	NA	NA	NA
XPR1	9213	broad.mit.edu	37	1	180775672	180775672	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:180775672delC	uc001goi.2	+	6	852	c.660delC	c.(658-660)GTCfs	p.V220fs	XPR1_uc009wxm.2_Frame_Shift_Del_p.V220fs|XPR1_uc009wxn.2_Frame_Shift_Del_p.V220fs	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	220	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GTTTACGTGTCCCCCCTTTGG	0.393			NA											49	133	---	---	---	---	NA	NA	NA	NA	NA
PTPRC	5788	broad.mit.edu	37	1	198673612	198673613	+	In_Frame_Ins	INS	-	-	GTG			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr1:198673612_198673613insGTG	uc001gur.1	+	8	844_845	c.664_665insGTG	c.(664-666)TCT>TGTGCT	p.222_222S>CA	PTPRC_uc001gus.1_In_Frame_Ins_p.174_174S>CA|PTPRC_uc001gut.1_In_Frame_Ins_p.61_61S>CA|PTPRC_uc009wzf.1_In_Frame_Ins_p.110_110S>CA|PTPRC_uc010ppg.1_In_Frame_Ins_p.158_158S>CA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	222	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TACTACTCCATCTAAGCCAACA	0.317			NA											10	58	---	---	---	---	NA	NA	NA	NA	NA
MGEA5	10724	broad.mit.edu	37	10	103577682	103577682	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr10:103577682delG	uc001ktv.2	-	1	541	c.98delC	c.(97-99)GCAfs	p.A33fs	MGEA5_uc010qqe.1_Frame_Shift_Del_p.A33fs|MGEA5_uc009xws.2_Frame_Shift_Del_p.A33fs|MGEA5_uc001ktw.2_Frame_Shift_Del_p.A33fs|MGEA5_uc009xwt.2_5'UTR|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	33					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TGCCGGAGCTGCCGGCGGCTC	0.716			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GAG	GAG	-	-	GAG	GAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:281553_281555delGAG	uc010qvs.1	+	4	1819_1821	c.1819_1821delGAG	c.(1819-1821)GAGdel	p.E611del	NLRP6_uc010qvt.1_In_Frame_Del_p.E611del	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.67			NA											7	189	---	---	---	---	NA	NA	NA	NA	NA
TP53I11	9537	broad.mit.edu	37	11	44956516	44956516	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:44956516delC	uc001myi.2	-	10	1094	c.489delG	c.(487-489)CTGfs	p.L163fs	TP53I11_uc001myf.1_Intron|TP53I11_uc001myj.2_Frame_Shift_Del_p.L163fs|TP53I11_uc001myk.2_Frame_Shift_Del_p.L163fs|TP53I11_uc001myl.2_Frame_Shift_Del_p.L163fs|TP53I11_uc001mym.2_Frame_Shift_Del_p.L110fs	NM_006034	NP_006025	O14683	P5I11_HUMAN	p53-induced protein	163	Poly-Leu.|Helical; (Potential).				negative regulation of cell proliferation|response to stress	integral to membrane				ovary(1)	1						TGACCAGGAGCAGCAGGATCC	0.602			NA											28	140	---	---	---	---	NA	NA	NA	NA	NA
STX5	6811	broad.mit.edu	37	11	62591720	62591724	+	Frame_Shift_Del	DEL	TGTTC	TGTTC	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	TGTTC	TGTTC	-	-	TGTTC	TGTTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:62591720_62591724delTGTTC	uc001nvh.2	-	10	976_980	c.822_826delGAACA	c.(820-828)CAGAACATTfs	p.Q274fs	STX5_uc010rmi.1_Frame_Shift_Del_p.Q178fs|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Frame_Shift_Del_p.Q220fs|STX5_uc010rmj.1_Frame_Shift_Del_p.Q274fs|STX5_uc001nvj.2_Frame_Shift_Del_p.Q89fs	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	274_276	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						GTCGACTCAATGTTCTGCATGGTGT	0.493			NA											12	159	---	---	---	---	NA	NA	NA	NA	NA
CTSF	8722	broad.mit.edu	37	11	66331419	66331420	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr11:66331419_66331420delCG	uc001oip.2	-	13	1529_1530	c.1439_1440delCG	c.(1438-1440)TCGfs	p.S480fs		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	480				SDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAV VD -> EFRCLSCIQPGHRQGWDHSISGPLEGK (in Ref. 9).	proteolysis	lysosome	cysteine-type endopeptidase activity				0						CCACCACCGCCGAGCTGGCCAT	0.673			NA											10	41	---	---	---	---	NA	NA	NA	NA	NA
B4GALNT1	2583	broad.mit.edu	37	12	58025102	58025103	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr12:58025102_58025103insC	uc001spg.1	-	3	695_696	c.263_264insG	c.(262-264)GGCfs	p.G88fs	B4GALNT1_uc010sru.1_Intron|B4GALNT1_uc010srv.1_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc001sph.2_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc001spi.2_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc010srw.1_Frame_Shift_Ins_p.G165fs	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	88	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGAGGGGGAGGCCCCCCCCACT	0.589			NA											9	298	---	---	---	---	NA	NA	NA	NA	NA
NFATC4	4776	broad.mit.edu	37	14	24845275	24845275	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:24845275delG	uc001wpc.2	+	8	2345	c.2024delG	c.(2023-2025)CGCfs	p.R675fs	NFATC4_uc010tok.1_Frame_Shift_Del_p.R738fs|NFATC4_uc010tol.1_Frame_Shift_Del_p.R738fs|NFATC4_uc010alr.2_Frame_Shift_Del_p.R738fs|NFATC4_uc010tom.1_Frame_Shift_Del_p.R688fs|NFATC4_uc010ton.1_Frame_Shift_Del_p.R688fs|NFATC4_uc010too.1_Frame_Shift_Del_p.R688fs|NFATC4_uc010alt.2_Frame_Shift_Del_p.R707fs|NFATC4_uc010top.1_Frame_Shift_Del_p.R707fs|NFATC4_uc010toq.1_Frame_Shift_Del_p.R707fs|NFATC4_uc010tor.1_Frame_Shift_Del_p.R675fs|NFATC4_uc010tos.1_Frame_Shift_Del_p.R605fs|NFATC4_uc010tot.1_Frame_Shift_Del_p.R663fs|NFATC4_uc010tou.1_Frame_Shift_Del_p.R605fs|NFATC4_uc010tov.1_Frame_Shift_Del_p.R663fs|NFATC4_uc010tow.1_Frame_Shift_Del_p.R605fs|NFATC4_uc010alv.2_Frame_Shift_Del_p.R663fs|NFATC4_uc010tox.1_Frame_Shift_Del_p.R605fs|NFATC4_uc001wpd.2_Frame_Shift_Del_p.R210fs|NFATC4_uc010toy.1_Frame_Shift_Del_p.R210fs|NFATC4_uc010toz.1_Frame_Shift_Del_p.R210fs|NFATC4_uc010tpa.1_5'UTR|NFATC4_uc010tpb.1_5'UTR	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	675	IPT/TIG.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		CGGAGGAAACGCAGTCCTACC	0.587			NA											64	173	---	---	---	---	NA	NA	NA	NA	NA
FLRT2	23768	broad.mit.edu	37	14	86088794	86088795	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr14:86088794_86088795insT	uc001xvr.2	+	2	1703_1704	c.936_937insT	c.(934-939)TGGTTTfs	p.W312fs	FLRT2_uc010atd.2_Frame_Shift_Ins_p.W312fs	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	312_313	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		ATAACCCTTGGTTTTGTGACTG	0.47			NA											69	248	---	---	---	---	NA	NA	NA	NA	NA
NAGPA	51172	broad.mit.edu	37	16	5083678	5083679	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:5083678_5083679delGC	uc002cyg.2	-	2	158_159	c.137_138delGC	c.(136-138)CGCfs	p.R46fs	ALG1_uc002cyj.2_5'Flank|NAGPA_uc002cyf.2_5'UTR|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_5'UTR|NAGPA_uc010uxx.1_Frame_Shift_Del_p.R46fs	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	46	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	CCCGGGGGAGGCGCGCGCGCGC	0.767			NA											8	37	---	---	---	---	NA	NA	NA	NA	NA
CBFA2T3	863	broad.mit.edu	37	16	88943549	88943549	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr16:88943549delG	uc002fmm.1	-	12	1983	c.1797delC	c.(1795-1797)CCCfs	p.P599fs	CBFA2T3_uc002fml.1_Frame_Shift_Del_p.P513fs|CBFA2T3_uc002fmk.1_Frame_Shift_Del_p.P98fs	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	599					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCACGGCTGTGGGGCCCTGCA	0.721			NA	T	RUNX1	AML								5	6	---	---	---	---	NA	NA	NA	NA	NA
ITGAE	3682	broad.mit.edu	37	17	3680872	3680873	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:3680872_3680873insC	uc002fwo.3	-	2	215_216	c.116_117insG	c.(115-117)AGCfs	p.S39fs		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	39	FG-GAP 1.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCAGAAGGGAGCTGAGCACGAA	0.634	NSCLC(182;635 2928 8995 38788)		NA											25	48	---	---	---	---	NA	NA	NA	NA	NA
PLD2	5338	broad.mit.edu	37	17	4711650	4711651	+	In_Frame_Ins	INS	-	-	AGG			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:4711650_4711651insAGG	uc002fzc.2	+	4	423_424	c.322_323insAGG	c.(322-324)CAG>CAGGAG	p.109_110insE	PLD2_uc010vsj.1_5'UTR|PLD2_uc002fzd.2_In_Frame_Ins_p.109_110insE	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	109_110	PX.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	CCGTCATTTTCAGGAGCTGCAT	0.55			NA											33	218	---	---	---	---	NA	NA	NA	NA	NA
SLFN5	162394	broad.mit.edu	37	17	33586549	33586549	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:33586549delC	uc002hjf.3	+	2	957	c.840delC	c.(838-840)TTCfs	p.F280fs	SLFN5_uc002hje.2_Frame_Shift_Del_p.F280fs|SLFN5_uc010wcg.1_Frame_Shift_Del_p.F280fs	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	280					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TCCTTAACTTCCTTGAAGTGC	0.473			NA											29	189	---	---	---	---	NA	NA	NA	NA	NA
DDX52	11056	broad.mit.edu	37	17	35981260	35981260	+	Frame_Shift_Del	DEL	C	C	-	rs146778713		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:35981260delC	uc002hoi.1	-	11	1451	c.1413delG	c.(1411-1413)TTGfs	p.L471fs	DDX52_uc002hoh.1_Frame_Shift_Del_p.L363fs	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	471	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				CTCTTGCTAGCAAGGCTGTAC	0.373			NA											39	48	---	---	---	---	NA	NA	NA	NA	NA
KCNJ2	3759	broad.mit.edu	37	17	68172112	68172112	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr17:68172112delG	uc010dfg.2	+	2	1333	c.932delG	c.(931-933)TGCfs	p.C311fs	KCNJ2_uc002jir.2_Frame_Shift_Del_p.C311fs	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	311	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					ACGACACAGTGCCGTAGCTCT	0.468			NA											11	86	---	---	---	---	NA	NA	NA	NA	NA
SETBP1	26040	broad.mit.edu	37	18	42530239	42530240	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:42530239_42530240insA	uc010dni.2	+	4	1230_1231	c.934_935insA	c.(934-936)CAGfs	p.Q312fs		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	312						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAACGGGCTTCAGCCCTTGGTG	0.535			NA							Schinzel-Giedion_syndrome				16	118	---	---	---	---	NA	NA	NA	NA	NA
LIPG	9388	broad.mit.edu	37	18	47110077	47110077	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr18:47110077delC	uc002ldv.2	+	8	1561	c.1309delC	c.(1309-1311)CCCfs	p.P437fs	LIPG_uc010xdh.1_Frame_Shift_Del_p.P363fs	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	437	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CCTGTCTCAACCCCGCAACCC	0.592	Pancreas(126;280 1778 12814 26243 34948)		NA											8	49	---	---	---	---	NA	NA	NA	NA	NA
EVC2	132884	broad.mit.edu	37	4	5620294	5620294	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:5620294delC	uc003gij.2	-	15	2671	c.2617delG	c.(2617-2619)GCCfs	p.A873fs	EVC2_uc011bwb.1_Frame_Shift_Del_p.A313fs|EVC2_uc003gik.2_Frame_Shift_Del_p.A793fs	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	873						integral to membrane				large_intestine(3)|ovary(2)	5						AGAACTCGGGCCCGGATCTTG	0.602			NA											34	29	---	---	---	---	NA	NA	NA	NA	NA
LGI2	55203	broad.mit.edu	37	4	25005529	25005530	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:25005529_25005530insT	uc003grf.2	-	8	1280_1281	c.1181_1182insA	c.(1180-1182)CAGfs	p.Q394fs		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	394	EAR 4.					extracellular region					0		Breast(46;0.173)				TGATGGGGACCTGGGAGCGGCT	0.51			NA											76	173	---	---	---	---	NA	NA	NA	NA	NA
RBM47	54502	broad.mit.edu	37	4	40434703	40434711	+	In_Frame_Del	DEL	CAGCGGCTG	CAGCGGCTG	-	rs139347188		TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CAGCGGCTG	CAGCGGCTG	-	-	CAGCGGCTG	CAGCGGCTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr4:40434703_40434711delCAGCGGCTG	uc003gvc.2	-	6	2209_2217	c.1499_1507delCAGCCGCTG	c.(1498-1509)GCAGCCGCTGTC>GTC	p.AAA500del	RBM47_uc003gvd.2_In_Frame_Del_p.AAA431del|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_In_Frame_Del_p.AAA462del	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	500_502	Ala-rich.					nucleus	nucleotide binding|RNA binding			breast(3)	3						GTGGGAATGACAgcggctgcggcggctgc	0.392			NA											28	71	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS2	9509	broad.mit.edu	37	5	178580494	178580494	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr5:178580494delC	uc003mjw.2	-	9	1513	c.1513delG	c.(1513-1515)GCGfs	p.A505fs	ADAMTS2_uc011dgm.1_Frame_Shift_Del_p.A505fs	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	505	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ACACTCACCGCCGTGCACATC	0.687			NA											33	35	---	---	---	---	NA	NA	NA	NA	NA
CDC5L	988	broad.mit.edu	37	6	44387252	44387252	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:44387252delT	uc003oxl.2	+	9	1418	c.1159delT	c.(1159-1161)TTGfs	p.L387fs		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	387	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TAATACCCCATTGCATGAGAG	0.443			NA											101	58	---	---	---	---	NA	NA	NA	NA	NA
TAAR2	9287	broad.mit.edu	37	6	132939166	132939166	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:132939166delC	uc003qdl.1	-	2	179	c.179delG	c.(178-180)GGCfs	p.G60fs	TAAR2_uc010kfr.1_Frame_Shift_Del_p.G15fs	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	60	Helical; Name=1; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		GGCAAGATTGCCAAATATTGT	0.423			NA											20	76	---	---	---	---	NA	NA	NA	NA	NA
UTRN	7402	broad.mit.edu	37	6	144782414	144782414	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:144782414delC	uc003qkt.2	+	21	2881	c.2789delC	c.(2788-2790)GCCfs	p.A930fs	UTRN_uc010khq.1_Frame_Shift_Del_p.A930fs	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	930					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAAAATAAGGCCCAGGTGTCT	0.383			NA											64	139	---	---	---	---	NA	NA	NA	NA	NA
GRM1	2911	broad.mit.edu	37	6	146755359	146755359	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr6:146755359delG	uc010khw.1	+	9	3482	c.3012delG	c.(3010-3012)CTGfs	p.L1004fs	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1004	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCTCTTCCTGGCCGAACCAG	0.677			NA											68	76	---	---	---	---	NA	NA	NA	NA	NA
ELMO1	9844	broad.mit.edu	37	7	37283961	37283962	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:37283961_37283962insA	uc003tfk.1	-	7	755_756	c.448_449insT	c.(448-450)TGCfs	p.C150fs	ELMO1_uc011kbc.1_Frame_Shift_Ins_p.C54fs|ELMO1_uc010kxg.1_Frame_Shift_Ins_p.C150fs	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	150					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATATTCTTACCAAGGCTTCATG	0.351			NA											26	110	---	---	---	---	NA	NA	NA	NA	NA
CDK13	8621	broad.mit.edu	37	7	40039085	40039085	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr7:40039085delG	uc003thh.3	+	4	2450	c.2168delG	c.(2167-2169)AGGfs	p.R723fs	CDK13_uc003thi.3_Frame_Shift_Del_p.R723fs|CDK13_uc011kbf.1_Frame_Shift_Del_p.R109fs	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	723	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TACAAAGCCAGGGATAAAGAC	0.398			NA											35	91	---	---	---	---	NA	NA	NA	NA	NA
KBTBD11	9920	broad.mit.edu	37	8	1949854	1949855	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr8:1949854_1949855delCG	uc003wpw.3	+	2	1462_1463	c.496_497delCG	c.(496-498)CGCfs	p.R166fs		NM_014867	NP_055682	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	166	BTB.									pancreas(1)	1		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		CGACTACTTCCGCGCGCGCGCG	0.767			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
SLC24A2	25769	broad.mit.edu	37	9	19577004	19577005	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:19577004_19577005insT	uc003zoa.1	-	5	1207_1208	c.1145_1146insA	c.(1144-1146)AAGfs	p.K382fs	SLC24A2_uc003zob.1_Frame_Shift_Ins_p.K365fs	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	382	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GAATTGAAGCCTTTTCTCTGAA	0.505			NA											18	80	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	9	90746725	90746725	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:90746725delC	uc011lti.1	-	4	1256	c.1227delG	c.(1225-1227)GGGfs	p.G409fs						SubName: Full=cDNA FLJ59639;												NA						GTAAAGCCAACCCACCTTCTA	0.493			NA											84	77	---	---	---	---	NA	NA	NA	NA	NA
BICD2	23299	broad.mit.edu	37	9	95477560	95477560	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7980-01A-11D-2184-08	TCGA-69-7980-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	125eda94-46ba-467b-93a5-909b1084136d	ff44cf5d-e9bb-4f79-82b0-056824e2d6b5	g.chr9:95477560delG	uc004aso.1	-	7	2501	c.2444delC	c.(2443-2445)CCGfs	p.P815fs	BICD2_uc004asp.1_Frame_Shift_Del_p.P815fs	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	815					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						CTTGGTCTTCGGGGCGGCTTT	0.682			NA											25	16	---	---	---	---	NA	NA	NA	NA	NA
