Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF1B	23095	broad.mit.edu	37	1	10292474	10292474	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:10292474A>G	uc001aqx.3	+	2	290	c.88A>G	c.(88-90)ATG>GTG	p.M30V	KIF1B_uc001aqv.3_Missense_Mutation_p.M30V|KIF1B_uc001aqw.3_Missense_Mutation_p.M30V|KIF1B_uc001aqy.2_Missense_Mutation_p.M30V|KIF1B_uc001aqz.2_Missense_Mutation_p.M30V|KIF1B_uc001ara.2_Missense_Mutation_p.M30V|KIF1B_uc001arb.2_Missense_Mutation_p.M30V|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	30	Kinesin-motor.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CATCATTCAGATGCAAGGCAA	0.468			NA											15	21					0	0	0.008871	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418			NA											3	52					0	0	0.009096	0	0
HECTD3	79654	broad.mit.edu	37	1	45471493	45471493	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:45471493C>A	uc009vxk.2	-	15	2006	c.1908G>T	c.(1906-1908)AAG>AAT	p.K636N	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Missense_Mutation_p.K246N|HECTD3_uc010olh.1_Missense_Mutation_p.K352N	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	636	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					CTGGGAAGTCCTTGCTCCAGC	0.428			NA											35	59					1.04594e-18	1.27436e-18	0.00623	1	0
FAF1	11124	broad.mit.edu	37	1	50941262	50941262	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:50941262G>A	uc009vyx.1	-	19	1806	c.1743C>T	c.(1741-1743)CCC>CCT	p.P581P	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Silent_p.P581P|FAF1_uc010onc.1_Silent_p.P339P	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	581	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		ACTCGCCACTGGGGGTCCGGA	0.542			NA											29	36					0	0	0.007291	0	0
FCGR3B	2215	broad.mit.edu	37	1	161599819	161599819	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:161599819A>G	uc009wul.2	-	3	342	c.68T>C	c.(67-69)CTC>CCC	p.L23P		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	23					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCCTTTGGGAGATCTTCTGA	0.547			NA											26	38					0	0	0.009535	0	0
SMG7	9887	broad.mit.edu	37	1	183486889	183486889	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:183486889G>A	uc001gqg.2	+	4	368	c.246G>A	c.(244-246)CCG>CCA	p.P82P	SMG7_uc010pob.1_Silent_p.P111P|SMG7_uc001gqf.2_Silent_p.P82P|SMG7_uc001gqh.2_Silent_p.P82P|SMG7_uc001gqi.2_Silent_p.P40P|SMG7_uc010poc.1_Silent_p.P40P	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	82					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GAGCAAATCCGAATCGGAGTG	0.418			NA											28	228					0	0	0.009535	0	0
TPR	7175	broad.mit.edu	37	1	186329117	186329117	+	Silent	SNP	A	A	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:186329117A>C	uc001grv.2	-	12	1500	c.1203T>G	c.(1201-1203)GCT>GCG	p.A401A	TPR_uc010pop.1_Silent_p.A477A	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	401					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTCCACATAAGCATTATAGA	0.328			NA	T	NTRK1	papillary thyroid								26	46					0	0	0.005443	0	0
NAV1	89796	broad.mit.edu	37	1	201777624	201777624	+	Silent	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:201777624G>T	uc001gwu.2	+	18	4262	c.3915G>T	c.(3913-3915)TCG>TCT	p.S1305S	NAV1_uc001gwx.2_Silent_p.S914S|MIR1231_hsa-mir-1231|MI0006321_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1308	Potential.				cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						AGGAGGTATCGGAGCTGCGCT	0.562			NA											36	75					9.8876e-21	1.24772e-20	0.004878	1	0
MIA3	375056	broad.mit.edu	37	1	222801788	222801788	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:222801788A>T	uc001hnl.2	+	4	1235	c.1226A>T	c.(1225-1227)GAG>GTG	p.E409V	MIA3_uc009xea.1_Missense_Mutation_p.E245V	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	409	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TCTAGTTCAGAGGAAGAAAAA	0.403			NA											59	114					0	0	0.01441	0	0
WDR64	128025	broad.mit.edu	37	1	241929587	241929587	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:241929587T>C	uc001hzf.1	+	10	1298	c.1145T>C	c.(1144-1146)ATA>ACA	p.I382T	WDR64_uc001hzg.1_Missense_Mutation_p.I128T	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	662	WD 9.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TATAATTTGATAGCAGCTGGA	0.338			NA											35	93					0	0	0.004289	0	0
MYPN	84665	broad.mit.edu	37	10	69934146	69934146	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr10:69934146C>G	uc001jnm.3	+	12	2482	c.2297C>G	c.(2296-2298)TCT>TGT	p.S766C	MYPN_uc001jnn.3_Missense_Mutation_p.S491C|MYPN_uc001jno.3_Missense_Mutation_p.S766C|MYPN_uc009xpt.2_Missense_Mutation_p.S766C|MYPN_uc010qit.1_Missense_Mutation_p.S472C|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	766						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CTCTTAGTGTCTCACCCCTCT	0.522			NA											76	64					0	0	0.01441	0	0
DCHS1	8642	broad.mit.edu	37	11	6647528	6647528	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:6647528C>T	uc001mem.1	-	16	6858	c.6448G>A	c.(6448-6450)GGA>AGA	p.G2150R		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2150	Cadherin 20.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAAAGGCTCCTCCACTCTCT	0.592			NA											4	20					0	0	0.000602	0	0
OR10A6	390093	broad.mit.edu	37	11	7949674	7949674	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:7949674C>T	uc010rbh.1	-	1	536	c.536G>A	c.(535-537)TGT>TAT	p.C179Y		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGGGGTTTCACAAGATATATG	0.363			NA											22	22					0	0	0.00278	0	0
HIPK3	10114	broad.mit.edu	37	11	33373334	33373334	+	Silent	SNP	G	G	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:33373334G>C	uc001mul.1	+	15	3258	c.2988G>C	c.(2986-2988)GTG>GTC	p.V996V	HIPK3_uc001mum.1_Silent_p.V975V|HIPK3_uc009yjv.1_Silent_p.V975V	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	996	Required for localization to nuclear speckles (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						CTGTTGTGGTGCCACCAGTGG	0.453			NA											21	29					0	0	0.00278	0	0
NR1H3	10062	broad.mit.edu	37	11	47283259	47283259	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:47283259G>A	uc009ylm.2	+	6	1091	c.870G>A	c.(868-870)CTG>CTA	p.L290L	NR1H3_uc009yll.1_Silent_p.L296L|NR1H3_uc010rhk.1_Silent_p.L296L|NR1H3_uc001nek.2_Silent_p.L245L|NR1H3_uc001nej.2_Intron|NR1H3_uc001nel.2_Silent_p.L245L|NR1H3_uc001nen.3_Intron|NR1H3_uc001nem.2_Silent_p.L290L|NR1H3_uc001nep.2_Intron	NM_005693	NP_005684	Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	290	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			ovary(2)|lung(1)	3						TTGCCCTGCTGAAGACCTCTG	0.582			NA											29	39					0	0	0.008361	0	0
INTS5	80789	broad.mit.edu	37	11	62416429	62416429	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:62416429G>A	uc001nud.2	-	2	1176	c.1123C>T	c.(1123-1125)CAC>TAC	p.H375Y	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	375					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CCTTGAAGGTGTTGCTGCAGC	0.602			NA											15	56					0	0	0.003163	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68682465	68682465	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:68682465A>G	uc001ook.1	+	6	988	c.886A>G	c.(886-888)ATC>GTC	p.I296V	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	296	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGTTGCAGATATCAGGAAGGA	0.552			NA											19	36					0	0	0.014323	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102999641	102999641	+	Silent	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:102999641G>T	uc001pho.2	+	13	2004	c.1860G>T	c.(1858-1860)GTG>GTT	p.V620V	DYNC2H1_uc001phn.1_Silent_p.V620V|DYNC2H1_uc009yxe.1_Silent_p.V620V	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	620	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTTTGTAGGTGGCACATTTTT	0.244			NA											21	35					1.01871e-10	1.19982e-10	0.008871	1	0
IGSF9B	22997	broad.mit.edu	37	11	133790096	133790096	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr11:133790096G>C	uc001qgx.3	-	18	3755	c.3524C>G	c.(3523-3525)CCC>CGC	p.P1175R		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1175	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGGGGCCGGGGCTGGGGCTC	0.701			NA											12	59					0	0	0.003163	0	0
ARID2	196528	broad.mit.edu	37	12	46231201	46231201	+	Splice_Site	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr12:46231201G>A	uc001ros.1	+	9	1120	c.1120_splice	c.e9+1	p.G374_splice	ARID2_uc001ror.2_Splice_Site_p.G374_splice|ARID2_uc009zkg.1_Splice_Site|ARID2_uc009zkh.1_Splice_Site_p.G20_splice|ARID2_uc001rot.1_Splice_Site_p.G20_splice	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AAGATGAGAGGTGAGTTTTCA	0.308			NA											22	32					0	0	0.014323	0	0
NFATC4	4776	broad.mit.edu	37	14	24839714	24839714	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr14:24839714G>A	uc001wpc.2	+	2	1431	c.1110G>A	c.(1108-1110)AAG>AAA	p.K370K	NFATC4_uc010tok.1_Silent_p.K433K|NFATC4_uc010tol.1_Silent_p.K433K|NFATC4_uc010alr.2_Silent_p.K433K|NFATC4_uc010als.2_Silent_p.K383K|NFATC4_uc010tom.1_Silent_p.K383K|NFATC4_uc010ton.1_Silent_p.K383K|NFATC4_uc010too.1_Silent_p.K383K|NFATC4_uc010alt.2_Silent_p.K402K|NFATC4_uc010top.1_Silent_p.K402K|NFATC4_uc010toq.1_Silent_p.K402K|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Silent_p.K370K|NFATC4_uc010tos.1_Silent_p.K300K|NFATC4_uc010tot.1_Silent_p.K358K|NFATC4_uc010tou.1_Silent_p.K300K|NFATC4_uc010tov.1_Silent_p.K358K|NFATC4_uc010tow.1_Silent_p.K300K|NFATC4_uc010alv.2_Silent_p.K358K|NFATC4_uc010tox.1_Silent_p.K300K|NFATC4_uc001wpd.2_5'Flank|NFATC4_uc010toy.1_5'Flank|NFATC4_uc010toz.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	370					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GTTCCCGGAAGGAGGTGGCTG	0.642			NA											10	61					0	0	0.010729	0	0
NFATC4	4776	broad.mit.edu	37	14	24839725	24839725	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr14:24839725G>A	uc001wpc.2	+	2	1442	c.1121G>A	c.(1120-1122)GGC>GAC	p.G374D	NFATC4_uc010tok.1_Missense_Mutation_p.G437D|NFATC4_uc010tol.1_Missense_Mutation_p.G437D|NFATC4_uc010alr.2_Missense_Mutation_p.G437D|NFATC4_uc010als.2_Missense_Mutation_p.G387D|NFATC4_uc010tom.1_Missense_Mutation_p.G387D|NFATC4_uc010ton.1_Missense_Mutation_p.G387D|NFATC4_uc010too.1_Missense_Mutation_p.G387D|NFATC4_uc010alt.2_Missense_Mutation_p.G406D|NFATC4_uc010top.1_Missense_Mutation_p.G406D|NFATC4_uc010toq.1_Missense_Mutation_p.G406D|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Missense_Mutation_p.G374D|NFATC4_uc010tos.1_Missense_Mutation_p.G304D|NFATC4_uc010tot.1_Missense_Mutation_p.G362D|NFATC4_uc010tou.1_Missense_Mutation_p.G304D|NFATC4_uc010tov.1_Missense_Mutation_p.G362D|NFATC4_uc010tow.1_Missense_Mutation_p.G304D|NFATC4_uc010alv.2_Missense_Mutation_p.G362D|NFATC4_uc010tox.1_Missense_Mutation_p.G304D|NFATC4_uc001wpd.2_5'Flank|NFATC4_uc010toy.1_5'Flank|NFATC4_uc010toz.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	374					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GAGGTGGCTGGCATGGACTAC	0.642			NA											11	63					0	0	0.013537	0	0
FAM179B	23116	broad.mit.edu	37	14	45431925	45431925	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr14:45431925C>G	uc001wvv.2	+	1	510	c.301C>G	c.(301-303)CAA>GAA	p.Q101E	FAM179B_uc001wvw.2_Missense_Mutation_p.Q101E|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.Q101E|FAM179B_uc001wvu.2_Missense_Mutation_p.Q101E	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	101							binding			skin(2)|upper_aerodigestive_tract(1)	3						TCGGCTCCTTCAACTCCTCCG	0.642			NA											50	76					0	0	0.01441	0	0
ITPKA	3706	broad.mit.edu	37	15	41793911	41793911	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr15:41793911T>G	uc001znz.2	+	3	676	c.665T>G	c.(664-666)CTG>CGG	p.L222R		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	222					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CTGGCGCGGCTGATGGCTGAC	0.692			NA											3	16					0	0	0.004672	0	0
LBXCOR1	390598	broad.mit.edu	37	15	68125572	68125572	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr15:68125572A>G	uc002aqy.1	+	9	2648	c.2648A>G	c.(2647-2649)TAT>TGT	p.Y883C		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	927					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						AAGGCGCGCTATGCCATCCAG	0.587			NA											13	19					0	0	0.004007	0	0
NEIL1	79661	broad.mit.edu	37	15	75646183	75646183	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr15:75646183G>A	uc002bad.2	+	6	1328	c.822G>A	c.(820-822)CGG>CGA	p.R274R	NEIL1_uc002bae.2_Silent_p.R360R|MIR631_hsa-mir-631|MI0003645_5'Flank	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	274					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						TGCAGGACCGGCATGGCCGTA	0.617			NA						BER_DNA_glycosylases					4	129					0	0	0.000602	0	0
AKAP13	11214	broad.mit.edu	37	15	86286756	86286756	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr15:86286756C>G	uc002blv.1	+	36	8262	c.8092C>G	c.(8092-8094)CCA>GCA	p.P2698A	AKAP13_uc002blu.1_Missense_Mutation_p.P2702A|AKAP13_uc002blw.1_Missense_Mutation_p.P1163A|AKAP13_uc002blx.1_Missense_Mutation_p.P943A	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2698	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GATGAGGATCCCATCGTTCTT	0.502	Melanoma(94;603 1453 3280 32295 32951)		NA											10	159					0	0	0.010729	0	0
KIAA0182	23199	broad.mit.edu	37	16	85704643	85704643	+	Missense_Mutation	SNP	G	G	A	rs2303203		TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr16:85704643G>A	uc002fix.2	+	15	3532	c.3458G>A	c.(3457-3459)CGA>CAA	p.R1153Q	KIAA0182_uc002fiw.2_Missense_Mutation_p.R1049Q|KIAA0182_uc002fiy.2_Missense_Mutation_p.R1080Q|KIAA0182_uc002fiz.2_Missense_Mutation_p.R295Q|KIAA0182_uc010cho.2_Missense_Mutation_p.R333Q	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	1153	Potential.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CAATGTAGACGACTGGAGGCC	0.562			NA											23	36					0	0	0.003954	0	0
AIPL1	23746	broad.mit.edu	37	17	6328905	6328905	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:6328905C>T	uc002gcp.2	-	6	1125	c.1030G>A	c.(1030-1032)GCA>ACA	p.A344T	AIPL1_uc002gcq.2_Missense_Mutation_p.A284T|AIPL1_uc002gcr.2_Missense_Mutation_p.A281T|AIPL1_uc010clk.2_Missense_Mutation_p.A322T|AIPL1_uc010cll.2_Missense_Mutation_p.A320T|AIPL1_uc002gcs.2_3'UTR	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	344					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		gatgactgtgcgggtggctct	0.259			NA											56	102					0	0	0.01441	0	0
CCDC55	84081	broad.mit.edu	37	17	28511752	28511752	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:28511752C>T	uc002heu.2	+	7	765	c.737C>T	c.(736-738)GCA>GTA	p.A246V	CCDC55_uc002hev.2_Missense_Mutation_p.A192V|CCDC55_uc010wbl.1_Missense_Mutation_p.A192V|CCDC55_uc010wbm.1_Missense_Mutation_p.A192V|CCDC55_uc002hex.2_Missense_Mutation_p.A192V	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	246					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						AACCCAGATGCAGACAGTGAC	0.413			NA											34	59					0	0	0.003755	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473891	43473891	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:43473891C>A	uc002iix.2	-	13	1561	c.1112G>T	c.(1111-1113)CGC>CTC	p.R371L	ARHGAP27_uc010dak.2_Missense_Mutation_p.R344L	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	712	Rho-GAP.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					CTGCACGAAGCGTGGCACCCG	0.731			NA											7	11					0.000157383	0.000173777	0.00308	1	0
GH2	2689	broad.mit.edu	37	17	61958402	61958402	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:61958402G>A	uc002jco.1	-	3	340	c.278C>T	c.(277-279)ACG>ATG	p.T93M	GH2_uc002jcj.2_Missense_Mutation_p.T93M|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Missense_Mutation_p.T93M|GH2_uc002jcm.1_Missense_Mutation_p.T93M|GH2_uc002jcn.1_Missense_Mutation_p.T78M	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	93						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						TTTCTGCTGCGTTTTCACCCT	0.572			NA											156	273					0	0	0.01441	0	0
CSH1	1442	broad.mit.edu	37	17	61972557	61972557	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:61972557C>A	uc002jcs.1	-	5	595	c.479G>T	c.(478-480)CGG>CTG	p.R160L	CSH2_uc002jck.2_Intron|CSH1_uc002jcp.1_Silent_p.P150P|CSH1_uc002jcq.1_Missense_Mutation_p.R121L|CSH1_uc002jcr.1_3'UTR|CSH1_uc002jct.1_Missense_Mutation_p.R126L|CSH1_uc002jcu.1_Silent_p.P244P|CSH1_uc002jcv.1_Missense_Mutation_p.R65L|CSH1_uc002jcw.2_Silent_p.P159P|CSH1_uc002jcy.2_3'UTR	NM_001317	NP_001308	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 isoform 1	160					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			skin(1)	1						CTGCCCAGTCCGGCGGCTGCC	0.547			NA							Russell-Silver_syndrome				57	99					3.13765e-25	4.00712e-25	0.01441	1	0
LLGL2	3993	broad.mit.edu	37	17	73566508	73566508	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr17:73566508C>T	uc002joh.2	+	16	2108	c.1954C>T	c.(1954-1956)CAG>TAG	p.Q652*	LLGL2_uc002joi.2_Nonsense_Mutation_p.Q652*|LLGL2_uc010dgg.1_Nonsense_Mutation_p.Q652*|LLGL2_uc002joj.2_Nonsense_Mutation_p.Q641*|LLGL2_uc010wsd.1_Nonsense_Mutation_p.Q279*	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	652	WD 10.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GTCCTTGCGTCAGTCATTCCG	0.692			NA											6	13					0	0	0.00308	0	0
FBN3	84467	broad.mit.edu	37	19	8191468	8191468	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:8191468C>A	uc002mjf.2	-	19	2459	c.2438G>T	c.(2437-2439)TGG>TTG	p.W813L		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	813	TB 4.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GATCTTCAGCCAGCAGGTGCC	0.677			NA											21	43					6.44725e-10	7.50999e-10	0.014323	1	0
MUC16	94025	broad.mit.edu	37	19	9073701	9073701	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:9073701G>T	uc002mkp.2	-	3	13949	c.13745C>A	c.(13744-13746)TCA>TAA	p.S4582*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4584	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACCAGGTATTGATATAGAAGC	0.517			NA											17	62					7.41877e-09	8.45581e-09	0.012319	1	0
EPHX3	79852	broad.mit.edu	37	19	15338342	15338342	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:15338342T>C	uc002nap.2	-	7	1198	c.989A>G	c.(988-990)CAC>CGC	p.H330R	EPHX3_uc002naq.2_Missense_Mutation_p.H330R	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	330						extracellular region	hydrolase activity				0						TGGCAGGATGTGGGCCTCCAA	0.612			NA											31	41					0	0	0.003755	0	0
HKR1	284459	broad.mit.edu	37	19	37853120	37853120	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:37853120T>G	uc002ogb.2	+	6	692	c.423T>G	c.(421-423)AGT>AGG	p.S141R	HKR1_uc002ofx.2_5'UTR|HKR1_uc002ofy.2_5'UTR|HKR1_uc002oga.2_Missense_Mutation_p.S123R|HKR1_uc010xto.1_Missense_Mutation_p.S123R|HKR1_uc002ogc.2_Missense_Mutation_p.S122R|HKR1_uc010xtp.1_Missense_Mutation_p.S80R|HKR1_uc002ogd.2_Missense_Mutation_p.S80R	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	141					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTTTTCAAGTTTATGGGCAG	0.463			NA											64	107					0	0	0.01441	0	0
PSG1	5669	broad.mit.edu	37	19	43382252	43382252	+	Silent	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:43382252T>C	uc002ovb.2	-	2	381	c.243A>G	c.(241-243)TCA>TCG	p.S81S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.S81S|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.S81S|PSG1_uc010eio.1_Silent_p.S81S|PSG1_uc002oux.1_Silent_p.S10S|PSG1_uc002ouy.1_Silent_p.S81S|PSG1_uc002ouz.1_Silent_p.S81S|PSG1_uc002ova.1_Silent_p.S81S|PSG1_uc002ovc.2_Silent_p.S81S|PSG1_uc002ovd.1_Silent_p.S81S	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	81	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				CTACTACATATGATGTAATGT	0.443			NA											221	337					0	0	0.01441	0	0
SHANK1	50944	broad.mit.edu	37	19	51165489	51165489	+	Silent	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:51165489C>T	uc002psx.1	-	23	6238	c.6219G>A	c.(6217-6219)TCG>TCA	p.S2073S	SHANK1_uc002psw.1_Silent_p.S1457S	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2073					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGAGGGAGCGCGAGGCCCCTG	0.687			NA											6	34					0	0	0.004482	0	0
KLK15	55554	broad.mit.edu	37	19	51330321	51330321	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:51330321G>A	uc002ptl.2	-	3	325	c.294C>T	c.(292-294)TAC>TAT	p.Y98Y	KLK15_uc002ptm.2_Silent_p.Y98Y|KLK15_uc002ptn.2_Silent_p.Y98Y|KLK15_uc002pto.2_Silent_p.Y97Y|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Silent_p.Y97Y|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	98	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		TGCGCGCTTCGTAGCGCGGGT	0.662	Pancreas(140;10 2513 7143 9246)		NA											42	63					0	0	0.01441	0	0
ZNF614	80110	broad.mit.edu	37	19	52519939	52519939	+	Silent	SNP	A	A	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:52519939A>C	uc002pyj.2	-	5	1314	c.912T>G	c.(910-912)GCT>GCG	p.A304A	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Silent_p.A7A	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	304	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TTCGCTGATGAGCAATTAGAT	0.403			NA											19	170					0	0	0.006122	0	0
PEG3	5178	broad.mit.edu	37	19	57327010	57327010	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr19:57327010T>A	uc002qnu.2	-	7	3151	c.2800A>T	c.(2800-2802)AAG>TAG	p.K934*	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Nonsense_Mutation_p.K905*|PEG3_uc002qnv.2_Nonsense_Mutation_p.K934*|PEG3_uc002qnw.2_Nonsense_Mutation_p.K810*|PEG3_uc002qnx.2_Nonsense_Mutation_p.K808*|PEG3_uc010etr.2_Nonsense_Mutation_p.K934*	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	934					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCACGAGCCTTCTGGTATTCA	0.463			NA											66	133					0	0	0.01441	0	0
RPS7	6201	broad.mit.edu	37	2	3627799	3627799	+	Silent	SNP	G	G	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:3627799G>C	uc002qxw.2	+	6	562	c.456G>C	c.(454-456)CGG>CGC	p.R152R	RPS7_uc002qxy.2_RNA	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	152					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		ATGGCAGCCGGCTCATAAAGG	0.483			NA											25	51					0	0	0.00632	0	0
WDR35	57539	broad.mit.edu	37	2	20135266	20135266	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:20135266G>A	uc002rdi.2	-	22	2654	c.2546C>T	c.(2545-2547)GCC>GTC	p.A849V	WDR35_uc002rdj.2_Missense_Mutation_p.A838V|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.A414V|WDR35_uc002rdk.3_Missense_Mutation_p.A414V	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	849										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGTGAAATGGCAAGGTTCTC	0.338			NA											22	58					0	0	0.00333	0	0
EPT1	85465	broad.mit.edu	37	2	26607932	26607932	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:26607932G>C	uc010ykz.1	+	8	984	c.837G>C	c.(835-837)TGG>TGC	p.W279C	EPT1_uc010eyl.1_RNA	NM_033505	NP_277040	Q9C0D9	EPT1_HUMAN	selenoprotein I	279					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0						GGATCCTTTGGTCACCTTCAG	0.348			NA											4	37					0	0	0.009096	0	0
CGREF1	10669	broad.mit.edu	37	2	27324165	27324165	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:27324165G>T	uc010eys.1	-	7	1025	c.883C>A	c.(883-885)CAA>AAA	p.Q295K	CGREF1_uc010ylf.1_Intron|CGREF1_uc002rip.1_Intron|CGREF1_uc002riq.2_Missense_Mutation_p.Q312K|CGREF1_uc010eyr.1_Missense_Mutation_p.Q417K|CGREF1_uc002rir.1_Missense_Mutation_p.Q295K|CGREF1_uc002ris.2_Missense_Mutation_p.F295L	NM_006569	NP_006560	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	295					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTCCACTTGAACAATGTGC	0.502			NA											117	221					1.89039e-43	2.53647e-43	0.01441	1	0
FAM123C	205147	broad.mit.edu	37	2	131519728	131519728	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:131519728C>A	uc002trw.2	+	2	273	c.83C>A	c.(82-84)GCT>GAT	p.A28D	FAM123C_uc010fmv.2_Missense_Mutation_p.A28D|FAM123C_uc010fms.1_Missense_Mutation_p.A28D|FAM123C_uc010fmt.1_Missense_Mutation_p.A28D|FAM123C_uc010fmu.1_Missense_Mutation_p.A28D	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	28										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GCAGCCGTGGCTGCAGCCAGG	0.637			NA											4	8					0.00909568	0.00993961	0.009096	1	0
TTN	7273	broad.mit.edu	37	2	179640620	179640620	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:179640620G>T	uc010zfg.1	-	28	6195	c.5971C>A	c.(5971-5973)CCT>ACT	p.P1991T	TTN_uc010zfh.1_Missense_Mutation_p.P1945T|TTN_uc010zfi.1_Missense_Mutation_p.P1945T|TTN_uc010zfj.1_Missense_Mutation_p.P1945T|TTN_uc002unb.2_Missense_Mutation_p.P1991T|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1991							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTCTTCAGGCACTTTTTCA	0.438			NA											26	269					1.42536e-11	1.69762e-11	0.004656	1	0
C20orf185	359710	broad.mit.edu	37	20	31651454	31651454	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr20:31651454G>A	uc002wym.1	+	6	625	c.625G>A	c.(625-627)GTG>ATG	p.V209M		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	209	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GCTGGGTGTGGTGAATGAGCT	0.572			NA											54	170					0	0	0.01441	0	0
KRTAP19-1	337882	broad.mit.edu	37	21	31852612	31852612	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr21:31852612C>T	uc011acx.1	-	1	25	c.25G>A	c.(25-27)GGA>AGA	p.G9R		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	9	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						CCCAGGCCTCCGTAGTAGCTG	0.557			NA											6	52					0	0	0.003163	0	0
ITGB2	3689	broad.mit.edu	37	21	46313397	46313397	+	Silent	SNP	G	G	A	rs61737080		TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr21:46313397G>A	uc002zgd.2	-	9	1190	c.1146C>T	c.(1144-1146)TAC>TAT	p.Y382Y	ITGB2_uc002zge.2_Silent_p.Y382Y|ITGB2_uc002zgf.3_Silent_p.Y382Y|ITGB2_uc011afl.1_Silent_p.Y304Y|ITGB2_uc010gpw.2_Silent_p.Y325Y|ITGB2_uc002zgg.2_Silent_p.Y382Y	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	382	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	AGAAGGAGTCGTAGGTGACTT	0.597			NA									OREG0026255	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	177					0	0	0.006999	0	0
STAC	6769	broad.mit.edu	37	3	36527665	36527665	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:36527665G>T	uc003cgh.1	+	5	650	c.611G>T	c.(610-612)CGC>CTC	p.R204L	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Missense_Mutation_p.R143L	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	204					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						GAGACCCTCCGCTTCGGCACC	0.562			NA											56	218					2.2129e-31	2.89589e-31	0.01441	1	0
LAMB2	3913	broad.mit.edu	37	3	49167754	49167754	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:49167754G>A	uc003cwe.2	-	9	1434	c.1135C>T	c.(1135-1137)CAT>TAT	p.H379Y	LAMB2_uc003cwf.1_Missense_Mutation_p.H379Y	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	379	Laminin EGF-like 2.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTGTGTTATGCTGACATCCA	0.597			NA											47	38					0	0	0.013114	0	0
LAMB2	3913	broad.mit.edu	37	3	49170269	49170269	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:49170269C>A	uc003cwe.2	-	1	331	c.32G>T	c.(31-33)GGA>GTA	p.G11V	LAMB2_uc003cwf.1_Missense_Mutation_p.G11V	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	11					cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGAGGCTGTCCCCTCCCTCT	0.622			NA											21	21					1.85244e-09	2.13433e-09	0.00333	1	0
SI	6476	broad.mit.edu	37	3	164777791	164777791	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:164777791C>T	uc003fei.2	-	10	1107	c.1045G>A	c.(1045-1047)GCA>ACA	p.A349T		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	349	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTCCAATATGCTGGCATTGCT	0.363			NA								HNSCC(35;0.089)			3	51					0	0	0.004672	0	0
MECOM	2122	broad.mit.edu	37	3	168833635	168833635	+	Silent	SNP	T	T	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:168833635T>A	uc003ffi.3	-	7	1730	c.1461A>T	c.(1459-1461)TCA>TCT	p.S487S	MECOM_uc010hwk.1_Silent_p.S510S|MECOM_uc003ffj.3_Silent_p.S552S|MECOM_uc011bpi.1_Silent_p.S488S|MECOM_uc003ffn.3_Silent_p.S487S|MECOM_uc003ffk.2_Silent_p.S487S|MECOM_uc003ffl.2_Silent_p.S647S|MECOM_uc011bpj.1_Silent_p.S675S|MECOM_uc011bpk.1_Silent_p.S477S|MECOM_uc010hwn.2_Silent_p.S675S	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	487					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CCAGTCCTGTTGAACCAAAGT	0.433			NA											29	101					0	0	0.010818	0	0
DVL3	1857	broad.mit.edu	37	3	183884764	183884764	+	Splice_Site	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:183884764G>T	uc003fms.2	+	11	1338	c.1198_splice	c.e11+1	p.R400_splice	DVL3_uc011bqw.1_Splice_Site_p.R383_splice|DVL3_uc003fmt.2_Splice_Site_p.R71_splice|DVL3_uc003fmu.2_Splice_Site_p.R232_splice	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3						canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GACACAGAGCGTGAGTGTCCC	0.622			NA											29	135					8.58068e-18	1.03358e-17	0.007291	1	0
PPP2R2C	5522	broad.mit.edu	37	4	6380272	6380272	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr4:6380272C>A	uc003gjc.2	-	3	566	c.196G>T	c.(196-198)GAA>TAA	p.E66*	PPP2R2C_uc003gjb.2_Nonsense_Mutation_p.E49*|PPP2R2C_uc011bwd.1_Nonsense_Mutation_p.E59*|PPP2R2C_uc011bwe.1_Nonsense_Mutation_p.E59*|PPP2R2C_uc003gja.2_Nonsense_Mutation_p.E66*|PPP2R2C_uc003gjd.1_Nonsense_Mutation_p.E154*	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	66				E -> D (in Ref. 2; AAG39636).	signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						ACGTCGTATTCGCCCTGGCTG	0.587			NA											77	83					1.13027e-35	1.49761e-35	0.01441	1	0
FSTL5	56884	broad.mit.edu	37	4	162577480	162577480	+	Silent	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr4:162577480A>G	uc003iqh.2	-	7	1330	c.894T>C	c.(892-894)AAT>AAC	p.N298N	FSTL5_uc003iqi.2_Silent_p.N297N|FSTL5_uc010iqv.2_Silent_p.N297N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	298	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATGTACTCACATTGATGTCTT	0.348			NA											6	8					0	0	0.001168	0	0
C7	730	broad.mit.edu	37	5	40937762	40937762	+	Silent	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr5:40937762G>T	uc003jmh.2	+	6	651	c.537G>T	c.(535-537)CTG>CTT	p.L179L	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	179	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TCTACAGGCTGAGTGGAAATG	0.299			NA											11	7					1.58986e-06	1.79283e-06	0.008291	1	0
EPB41L4A	64097	broad.mit.edu	37	5	111519749	111519749	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr5:111519749T>A	uc003kpv.1	-	18	1860	c.1586A>T	c.(1585-1587)GAC>GTC	p.D529V	EPB41L4A_uc003kpp.1_Missense_Mutation_p.D156V	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	529						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GTTGTTGGGGTCGGCTTGGTT	0.428			NA											40	82					0	0	0.011902	0	0
TMEM173	340061	broad.mit.edu	37	5	138861279	138861279	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr5:138861279G>C	uc003lep.2	-	3	262	c.11C>G	c.(10-12)TCC>TGC	p.S4C		NM_198282	NP_938023	Q86WV6	TM173_HUMAN	transmembrane protein 173	4	Cytoplasmic (Potential).				activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			upper_aerodigestive_tract(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ATGCAGGCTGGAGTGGGGCAT	0.627			NA											13	37					0	0	0.001855	0	0
HLA-H	3136	broad.mit.edu	37	6	29855952	29855952	+	Missense_Mutation	SNP	A	A	C	rs72843343		TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr6:29855952A>C	uc010jro.2	+	2	241	c.189A>C	c.(187-189)GAA>GAC	p.E63D	HLA-G_uc011dmb.1_Intron|HLA-H_uc003nod.2_RNA					SubName: Full=cDNA FLJ52667, highly similar to HLA class I histocompatibility antigen, alpha chain H;												0						CACAGACTGAACGAGAGAACC	0.682			NA											3	18					0	0	0.001168	0	0
BAT2	7916	broad.mit.edu	37	6	31599748	31599748	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr6:31599748C>T	uc003nvb.3	+	16	3547	c.3298C>T	c.(3298-3300)CGG>TGG	p.R1100W	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.R1100W	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1100	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						AATCCCCAAGCGGCGCCGGCA	0.637			NA											7	53					0	0	0.004482	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333333	33333333	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr6:33333333G>A	uc003shx.2	-	1	807	c.673C>T	c.(673-675)CCT>TCT	p.P225S		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						AGTTAGACAGGAGGCAGCAGC	0.577			NA											3	17					0	0	0.004672	0	0
TBX18	9096	broad.mit.edu	37	6	85446869	85446869	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr6:85446869C>T	uc003pkl.1	-	8	1358	c.1358G>A	c.(1357-1359)AGG>AAG	p.R453K	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	453					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GGAGGGAGTCCTGGGCGGGGC	0.602			NA											37	40					0	0	0.004878	0	0
STK31	56164	broad.mit.edu	37	7	23751905	23751905	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr7:23751905G>T	uc003sws.3	+	3	217	c.150G>T	c.(148-150)CAG>CAT	p.Q50H	STK31_uc003swt.3_Missense_Mutation_p.Q27H|STK31_uc011jze.1_Missense_Mutation_p.Q50H|STK31_uc010kuq.2_Missense_Mutation_p.Q27H	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	50							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TTTGGGCCCAGGTAAATAGCA	0.373			NA											42	84					1.23713e-20	1.54277e-20	0.01441	1	0
SLC13A1	6561	broad.mit.edu	37	7	122768953	122768953	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr7:122768953A>C	uc003vkm.2	-	10	1104	c.1079T>G	c.(1078-1080)CTA>CGA	p.L360R	SLC13A1_uc010lks.2_Missense_Mutation_p.L236R	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	360	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	ACTAAACCATAGCAGAGCCAT	0.418			NA											15	40					0	0	0.003163	0	0
SLC25A37	51312	broad.mit.edu	37	8	23429006	23429006	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:23429006T>C	uc003xdo.2	+	4	808	c.655T>C	c.(655-657)TAT>CAT	p.Y219H	SLC25A37_uc003xdp.2_RNA|SLC25A37_uc010ltz.2_RNA|SLC25A37_uc003xdq.2_RNA|SLC25A37_uc003xdr.1_RNA|uc003xds.2_5'Flank	NM_016612	NP_057696	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25, member 37	219	Helical; Name=4; (Potential).|Solcar 2.				ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CTTCATCACCTATGAGTTCCT	0.657			NA											3	63					0	0	0.009096	0	0
C8orf41	80185	broad.mit.edu	37	8	33361019	33361019	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:33361019T>C	uc003xjl.3	-	5	1712	c.1187A>G	c.(1186-1188)GAT>GGT	p.D396G	C8orf41_uc003xjk.3_Missense_Mutation_p.D365G|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Missense_Mutation_p.D396G|C8orf41_uc003xjn.1_Missense_Mutation_p.D396G	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	396							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		CTCAGGTCCATCATAAACCTC	0.443			NA											3	192					0	0	0.004672	0	0
KLHL38	340359	broad.mit.edu	37	8	124659239	124659239	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:124659239T>C	uc003yqs.1	-	2	1390	c.1366A>G	c.(1366-1368)AGA>GGA	p.R456G		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	456	Kelch 4.										0						CACGAGTTTCTGGAAATGTGA	0.438			NA											53	122					0	0	0.01441	0	0
RNF139	11236	broad.mit.edu	37	8	125498172	125498172	+	Silent	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:125498172G>A	uc003yrc.2	+	2	625	c.282G>A	c.(280-282)TTG>TTA	p.L94L		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	94	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTTCAGTGTTGGTGAATTATT	0.428			NA							Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				41	96					0	0	0.011902	0	0
ADCY8	114	broad.mit.edu	37	8	132051638	132051638	+	Silent	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:132051638C>T	uc003ytd.3	-	1	1198	c.942G>A	c.(940-942)GCG>GCA	p.A314A	ADCY8_uc010mds.2_Silent_p.A314A	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	314	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGAAATGACCGCCAGCCGGG	0.587			NA								HNSCC(32;0.087)			30	86					0	0	0.013726	0	0
FAM135B	51059	broad.mit.edu	37	8	139151255	139151255	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr8:139151255A>G	uc003yuy.2	-	18	4046	c.3875T>C	c.(3874-3876)TTC>TCC	p.F1292S	FAM135B_uc003yux.2_Missense_Mutation_p.F1193S|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1292										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGGTAGAGGAAACATTTGCG	0.433			NA								HNSCC(54;0.14)			41	86					0	0	0.010771	0	0
PTGS1	5742	broad.mit.edu	37	9	125148924	125148924	+	Silent	SNP	C	C	T			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr9:125148924C>T	uc004bmg.1	+	9	1344	c.1209C>T	c.(1207-1209)TAC>TAT	p.Y403Y	PTGS1_uc011lys.1_Intron|PTGS1_uc010mwb.1_Intron|PTGS1_uc004bmf.1_Intron|PTGS1_uc004bmh.1_Silent_p.Y294Y|PTGS1_uc011lyt.1_Silent_p.Y294Y	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	403					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AGTACAGCTACGAGCAGTTCT	0.557			NA											14	124					0	0	0.00245	0	0
GTF3C5	9328	broad.mit.edu	37	9	135917627	135917627	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr9:135917627G>A	uc004cci.3	+	2	644	c.307G>A	c.(307-309)GCC>ACC	p.A103T	GTF3C5_uc010mzz.2_Intron|GTF3C5_uc004ccj.3_Missense_Mutation_p.A103T	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	103						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		GGGCACTGAGGCCCACTCCGA	0.532			NA											32	116					0	0	0.004289	0	0
NDP	4693	broad.mit.edu	37	X	43817761	43817761	+	Missense_Mutation	SNP	T	T	C	rs104894870		TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chrX:43817761T>C	uc004dga.3	-	2	710	c.131A>G	c.(130-132)TAT>TGT	p.Y44C		NM_000266	NP_000257	Q00604	NDP_HUMAN	norrin precursor	44	CTCK.		Y -> C (in ND).		canonical Wnt receptor signaling pathway|cell proliferation|cell-cell signaling|nervous system development|positive regulation of transcription, DNA-dependent|sensory perception of sound|vacuole organization|visual perception	extracellular matrix|extracellular space	cell surface binding|frizzled binding|growth factor activity|protein homodimerization activity				0						AGAATCCACATAGTGGTGCCT	0.483			NA											7	88					0	0	0.004482	0	0
RIT1	6016	broad.mit.edu	37	1	155874278	155874283	+	In_Frame_Del	DEL	TGGCTG	TGGCTG	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	TGGCTG	TGGCTG	-	-	TGGCTG	TGGCTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:155874278_155874283delTGGCTG	uc001fmh.1	-	5	435_440	c.248_253delCAGCCA	c.(247-255)ACAGCCATG>ATG	p.TA83del	RIT1_uc010pgr.1_In_Frame_Del_p.TA47del	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	83_84					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			TGGTCCCGCATGGCTGTAAACTCTGC	0.417			NA											35	35	---	---	---	---	NA	NA	NA	NA	NA
EDEM3	80267	broad.mit.edu	37	1	184690453	184690454	+	Frame_Shift_Ins	INS	-	-	C			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr1:184690453_184690454insC	uc010pok.1	-	9	1181_1182	c.920_921insG	c.(919-921)GGAfs	p.G307fs	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Frame_Shift_Ins_p.G307fs|EDEM3_uc001gqy.2_Frame_Shift_Ins_p.G230fs	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	307					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						AACTGTCATCTCCAAGCAAGAC	0.297			NA											60	37	---	---	---	---	NA	NA	NA	NA	NA
NLRC5	84166	broad.mit.edu	37	16	57073747	57073747	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr16:57073747delG	uc002ekk.1	+	16	3081	c.2856delG	c.(2854-2856)AAGfs	p.K952fs	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Frame_Shift_Del_p.K701fs|NLRC5_uc002ekl.2_Frame_Shift_Del_p.K757fs|NLRC5_uc002ekm.2_Frame_Shift_Del_p.K757fs|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_5'Flank|NLRC5_uc002ekp.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	952	LRR 7.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGAGCAGAAGGGGCCCCAGG	0.572			NA											80	132	---	---	---	---	NA	NA	NA	NA	NA
TMCO7	79613	broad.mit.edu	37	16	68894367	68894367	+	Frame_Shift_Del	DEL	A	A	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr16:68894367delA	uc002ewi.3	+	2	687	c.675delA	c.(673-675)GCAfs	p.A225fs	TMCO7_uc002ewh.2_Frame_Shift_Del_p.A225fs	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	225						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		ATATCGCAGCAGGTCTGTGCC	0.493			NA											71	118	---	---	---	---	NA	NA	NA	NA	NA
SYT4	6860	broad.mit.edu	37	18	40854284	40854284	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr18:40854284delC	uc002law.2	-	2	479	c.110delG	c.(109-111)TGCfs	p.C37fs	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Frame_Shift_Del_p.C19fs|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	37	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TCTCTGACAGCAGATCCATGC	0.408	NSCLC(85;81 1419 2855 22820 35912)		NA											11	38	---	---	---	---	NA	NA	NA	NA	NA
ZNF513	130557	broad.mit.edu	37	2	27600974	27600985	+	In_Frame_Del	DEL	GGGCCCTGGGGC	GGGCCCTGGGGC	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	GGGCCCTGGGGC	GGGCCCTGGGGC	-	-	GGGCCCTGGGGC	GGGCCCTGGGGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr2:27600974_27600985delGGGCCCTGGGGC	uc002rkk.2	-	4	1253_1264	c.1053_1064delGCCCCAGGGCCC	c.(1051-1065)GGGCCCCAGGGCCCC>GGC	p.PQGP352del	ZNF513_uc002rkj.2_In_Frame_Del_p.PQGP290del	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	352_355					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGTCACTGGGGCCCTGGGGCCCCCCACTGG	0.642			NA											19	120	---	---	---	---	NA	NA	NA	NA	NA
SGEF	26084	broad.mit.edu	37	3	153839829	153839829	+	Frame_Shift_Del	DEL	T	T	-			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr3:153839829delT	uc011bog.1	+	2	259	c.48delT	c.(46-48)CCTfs	p.P16fs	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Frame_Shift_Del_p.P16fs	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	16					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCATAACCCCTTTGTGGCGGA	0.612			NA											7	21	---	---	---	---	NA	NA	NA	NA	NA
RBM16	22828	broad.mit.edu	37	6	155114064	155114065	+	Frame_Shift_Ins	INS	-	-	A			TCGA-73-4675-01A-01D-1265-08	TCGA-73-4675-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	59dad620-51f8-4c12-8b09-e635fbde126e	dff88708-c643-4f32-a4e0-88cc1d24807a	g.chr6:155114064_155114065insA	uc003qqa.2	+	6	661_662	c.429_430insA	c.(427-432)GTCACAfs	p.V143fs	RBM16_uc011efj.1_Frame_Shift_Ins_p.V209fs|RBM16_uc011efk.1_Frame_Shift_Ins_p.V188fs|RBM16_uc003qpz.2_Frame_Shift_Ins_p.V143fs|RBM16_uc010kji.2_Frame_Shift_Ins_p.V164fs	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	143_144					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CTCCAGTTGTCACACCTGTTTT	0.396			NA											18	23	---	---	---	---	NA	NA	NA	NA	NA
