Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAN1C1	57134	broad.mit.edu	37	1	26012972	26012972	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:26012972G>C	uc001bkm.2	+	2	912	c.582G>C	c.(580-582)ATG>ATC	p.M194I	MAN1C1_uc009vry.1_Missense_Mutation_p.M14I	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	194	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GTTATGCAATGGGGAAAAACG	0.488			NA											24	69					0	0	0.005443	0	0
ARID1A	8289	broad.mit.edu	37	1	27057727	27057727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:27057727C>T	uc001bmv.1	+	3	1808	c.1435C>T	c.(1435-1437)CAG>TAG	p.Q479*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q479*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q479*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q96*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	479	Poly-Gln.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCCTCACCCTCAGCAGCAGCA	0.557			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								85	89					0	0	0.01441	0	0
RPE65	6121	broad.mit.edu	37	1	68912489	68912489	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:68912489A>G	uc001dei.1	-	3	203	c.149T>C	c.(148-150)TTT>TCT	p.F50S		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	50					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						TCCAACTTCAAAGAGTCCTGG	0.507			NA											25	27					0	0	0.016522	0	0
AK5	26289	broad.mit.edu	37	1	77949040	77949040	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:77949040G>T	uc001dhn.2	+	9	1355	c.1098G>T	c.(1096-1098)ATG>ATT	p.M366I	AK5_uc001dho.2_Missense_Mutation_p.M340I	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	366					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						AGGACACTATGGGAGGTGAGT	0.328			NA											4	128					0.00116845	0.00125277	0.001168	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145021125	145021125	+	Silent	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:145021125C>T	uc001elx.3	-	2	398	c.63G>A	c.(61-63)ACG>ACA	p.T21T	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elm.3_5'UTR|PDE4DIP_uc001eln.3_Silent_p.T21T|PDE4DIP_uc001elo.2_Silent_p.T92T|PDE4DIP_uc001emh.2_Silent_p.T92T	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGTGTGACTCGTTCTGGGTA	0.353			NA	T	PDGFRB	MPD								15	196					0	0	0.004007	0	0
SHC1	6464	broad.mit.edu	37	1	154942831	154942831	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:154942831G>A	uc001ffv.2	-	1	393	c.172C>T	c.(172-174)CTG>TTG	p.L58L	SHC1_uc001ffz.1_5'Flank|SHC1_uc001ffw.2_Silent_p.L58L|SHC1_uc001ffx.2_Intron|SHC1_uc001ffy.2_Intron	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	58					activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AAGGAGCACAGGGTAGTGGGA	0.672	NSCLC(4;32 234 1864 2492 3259 13747 17376)		NA											3	41					0	0	0.009096	0	0
KIAA0907	22889	broad.mit.edu	37	1	155891353	155891353	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:155891353T>C	uc001fmi.1	-	10	1103	c.1079A>G	c.(1078-1080)TAT>TGT	p.Y360C	KIAA0907_uc001fmj.1_Missense_Mutation_p.Y360C|KIAA0907_uc009wrk.1_Missense_Mutation_p.Y217C|KIAA0907_uc009wrl.1_Intron|SNORA42_uc001fmk.1_5'Flank|KIAA0907_uc001fml.1_Intron	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	360	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			ACCAGACTGATAGCCATTGGA	0.488			NA											20	86					0	0	0.010504	0	0
IGSF9	57549	broad.mit.edu	37	1	159900162	159900162	+	Silent	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:159900162C>T	uc001fur.2	-	15	2079	c.1881G>A	c.(1879-1881)CCG>CCA	p.P627P	IGSF9_uc001fuq.2_Silent_p.P611P|IGSF9_uc001fup.2_5'UTR	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	627	Fibronectin type-III 2.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			CCAGACCCCGCGGAGGGGACA	0.652			NA											26	78					0	0	0.021523	0	0
F5	2153	broad.mit.edu	37	1	169512220	169512220	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:169512220A>G	uc001ggg.1	-	13	2253	c.2108T>C	c.(2107-2109)GTC>GCC	p.V703A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	703	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGTAGCCATGACTGTAGATTC	0.413			NA											15	300					0	0	0.020292	0	0
BAT2L2	23215	broad.mit.edu	37	1	171510842	171510842	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:171510842C>T	uc010pmg.1	+	16	4497	c.4231C>T	c.(4231-4233)CGA>TGA	p.R1411*	BAT2L2_uc010pmh.1_Nonsense_Mutation_p.R388*	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1411	Arg-rich.						protein C-terminus binding				0						AAAATTTGAGCGAAAATTTGA	0.488			NA											9	31					0	0	0.004482	0	0
HMCN1	83872	broad.mit.edu	37	1	185897775	185897775	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:185897775G>A	uc001grq.1	+	10	1757	c.1528G>A	c.(1528-1530)GCA>ACA	p.A510T		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	510	Ig-like C2-type 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TACTGGACGGGCACAGACATT	0.413			NA											53	90					0	0	0.01441	0	0
RGS2	5997	broad.mit.edu	37	1	192778207	192778207	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:192778207A>T	uc001gsl.2	+	1	39	c.6A>T	c.(4-6)CAA>CAT	p.Q2H		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	2					cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						CGATAATGCAAAGTGCTATGT	0.607	Pancreas(71;51 2183 4981)		NA											12	28					0	0	0.010729	0	0
DISP1	84976	broad.mit.edu	37	1	223178044	223178044	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr1:223178044T>G	uc001hnu.1	+	8	3452	c.3305T>G	c.(3304-3306)GTT>GGT	p.V1102G		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1102					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CCCTCCACAGTTCTAGCTTAC	0.562			NA											30	21					0	0	0.008361	0	0
OR51F1	256892	broad.mit.edu	37	11	4790747	4790747	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr11:4790747T>C	uc010qyl.1	-	1	401	c.401A>G	c.(400-402)TAC>TGC	p.Y134C		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	134						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AATGGTAGTGTACCTCAGAGG	0.423			NA											12	41					0	0	0.016723	0	0
CCDC67	159989	broad.mit.edu	37	11	93090193	93090193	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr11:93090193A>G	uc001pdq.2	+	4	381	c.281A>G	c.(280-282)CAA>CGA	p.Q94R	CCDC67_uc001pdo.1_Missense_Mutation_p.Q94R|CCDC67_uc001pdp.2_Missense_Mutation_p.Q94R	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	94	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GGACAACTACAAAGCCTAAAG	0.289			NA											4	7					0	0	0.009096	0	0
HEPHL1	341208	broad.mit.edu	37	11	93779059	93779059	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr11:93779059G>A	uc001pep.2	+	2	548	c.391G>A	c.(391-393)GTT>ATT	p.V131I		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	131	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TCCACATGGCGTTTTCTACAA	0.403			NA											9	39					0	0	0.010729	0	0
WBP11	51729	broad.mit.edu	37	12	14943683	14943683	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr12:14943683C>A	uc001rci.2	-	10	1177	c.1016G>T	c.(1015-1017)GGT>GTT	p.G339V		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	339					mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						GATTTCTTGACCTGAAAGAAA	0.378			NA											20	89					2.89027e-11	3.53633e-11	0.014323	1	0
TENC1	23371	broad.mit.edu	37	12	53455027	53455027	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr12:53455027G>C	uc001sbp.2	+	20	3472	c.3337G>C	c.(3337-3339)GAT>CAT	p.D1113H	TENC1_uc001sbl.2_Missense_Mutation_p.D989H|TENC1_uc001sbn.2_Missense_Mutation_p.D1123H|TENC1_uc001sbq.2_Missense_Mutation_p.D511H|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Missense_Mutation_p.D608H|TENC1_uc001sbs.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1113	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						TCTGCTCTCAGATAATGTCCC	0.617			NA											27	52					0	0	0.004656	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373716	86373716	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr12:86373716A>T	uc001tai.3	-	8	2038	c.788T>A	c.(787-789)CTC>CAC	p.L263H	MGAT4C_uc001tal.3_Missense_Mutation_p.L263H|MGAT4C_uc001taj.3_Missense_Mutation_p.L263H|MGAT4C_uc001tak.3_Missense_Mutation_p.L263H|MGAT4C_uc010sum.1_Missense_Mutation_p.L287H|MGAT4C_uc001tah.3_Missense_Mutation_p.L263H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	263	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						AGAATGATAGAGTTTACCAAT	0.373			NA											39	48					0	0	0.00623	0	0
FAM124A	220108	broad.mit.edu	37	13	51855250	51855250	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr13:51855250C>A	uc001vfg.1	+	4	1630	c.1499C>A	c.(1498-1500)GCT>GAT	p.A500D	FAM124A_uc001vff.1_Missense_Mutation_p.A536D	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	500										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		GCTCCCCCAGCTCCCAGCACC	0.617			NA											14	43					6.31663e-08	7.38123e-08	0.003163	1	0
TEP1	7011	broad.mit.edu	37	14	20871907	20871907	+	Missense_Mutation	SNP	T	T	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:20871907T>G	uc001vxe.2	-	6	1209	c.1169A>C	c.(1168-1170)CAC>CCC	p.H390P	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	390	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCGGCGGGGGTGTCTCTTGGC	0.627			NA											5	63					0	0	0.008871	0	0
LRFN5	145581	broad.mit.edu	37	14	42356002	42356002	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:42356002G>T	uc001wvm.2	+	3	1372	c.174G>T	c.(172-174)TTG>TTT	p.L58F	LRFN5_uc010ana.2_Missense_Mutation_p.L58F	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	58	Extracellular (Potential).|LRR 1.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AACTGCGGTTGGCAGACAATT	0.383			NA								HNSCC(30;0.082)			18	26					0.00121646	0.00129094	0.008871	1	0
PLEKHH1	57475	broad.mit.edu	37	14	68042651	68042651	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:68042651C>T	uc001xjl.1	+	16	2423	c.2281C>T	c.(2281-2283)CAC>TAC	p.H761Y	PLEKHH1_uc010tsw.1_Missense_Mutation_p.H329Y|PLEKHH1_uc001xjn.1_Missense_Mutation_p.H276Y|PLEKHH1_uc010tsx.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	761	PH 2.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GCTTTCCTCCCACTGCACCCT	0.592			NA											10	24					0	0	0.008291	0	0
SPATA7	55812	broad.mit.edu	37	14	88904759	88904759	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:88904759A>C	uc001xwq.2	+	12	1944	c.1793A>C	c.(1792-1794)GAT>GCT	p.D598A	SPATA7_uc001xwr.2_Missense_Mutation_p.D566A|SPATA7_uc001xws.2_Missense_Mutation_p.D534A|SPATA7_uc001xwt.2_Missense_Mutation_p.D492A|SPATA7_uc001xwu.2_Missense_Mutation_p.D113A	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	598					response to stimulus|visual perception					ovary(1)	1						TGCCCTTTGGATGTTTAATCT	0.313			NA											15	36					0	0	0.020292	0	0
KIF26A	26153	broad.mit.edu	37	14	104642531	104642531	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:104642531G>A	uc001yos.3	+	12	3406	c.3406G>A	c.(3406-3408)GAC>AAC	p.D1136N		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1136					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CTTCAGCCCCGACTCGCTGGC	0.697			NA											3	9					0	0	0.009096	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414090	105414090	+	Silent	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr14:105414090C>A	uc010axc.1	-	7	7818	c.7698G>T	c.(7696-7698)CTG>CTT	p.L2566L	AHNAK2_uc001ypx.2_Silent_p.L2466L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2566						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCACCTTGGGCAGGTGCCCTT	0.632			NA											79	164					6.86016e-32	8.80811e-32	0.01441	1	0
GP2	2813	broad.mit.edu	37	16	20327347	20327347	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr16:20327347G>T	uc002dgv.2	-	10	1524	c.1441C>A	c.(1441-1443)CAA>AAA	p.Q481K	GP2_uc002dgw.2_Missense_Mutation_p.Q478K|GP2_uc002dgx.2_Missense_Mutation_p.Q334K|GP2_uc002dgy.2_Missense_Mutation_p.Q331K	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	481	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CTGCGGACTTGACTTCTTGAG	0.483			NA											12	73					0.000151284	0.000165617	0.016723	1	0
TMEM159	57146	broad.mit.edu	37	16	21172524	21172524	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr16:21172524G>C	uc002dif.3	+	2	382	c.21G>C	c.(19-21)CAG>CAC	p.Q7H	DNAH3_uc010vbe.1_5'Flank|TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Missense_Mutation_p.Q7H|TMEM159_uc002dih.3_Missense_Mutation_p.Q7H	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	7						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		AGGAGCCCCAGAGTATCTCAA	0.453			NA											3	68					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	16					0	0	0.00499	0	0
KRT20	54474	broad.mit.edu	37	17	39034573	39034573	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr17:39034573G>A	uc002hvl.2	-	6	1005	c.963C>T	c.(961-963)TAC>TAT	p.Y321Y		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	321	Rod.|Coil 2.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				ACTGGCTGCTGTAACGGGCCT	0.483			NA											4	97					0	0	0.009096	0	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394662	39394662	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr17:39394662G>T	uc002hwh.3	+	1	393	c.359G>T	c.(358-360)AGC>ATC	p.S120I	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	120	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CTAAACCAGAGCTGTGGCTCC	0.627			NA											32	54					6.2361e-21	7.90921e-21	0.007835	1	0
KRTAP9-4	85280	broad.mit.edu	37	17	39406331	39406331	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr17:39406331G>T	uc002hwi.2	+	1	393	c.359G>T	c.(358-360)AGC>ATC	p.S120I	KRTAP9-9_uc010wfq.1_Intron	NM_033191	NP_149461	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	120	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CTAAACCAGAGCTGTGGCTCC	0.602			NA											12	152					0.000151284	0.000165617	0.016723	1	0
TCF3	6929	broad.mit.edu	37	19	1625599	1625599	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr19:1625599G>A	uc002ltr.2	-	7	542	c.475C>T	c.(475-477)CGG>TGG	p.R159W	TCF3_uc002ltt.3_Missense_Mutation_p.R159W|TCF3_uc002ltq.2_Missense_Mutation_p.R108W|TCF3_uc002lts.1_Missense_Mutation_p.R75W	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	159					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCTCTCCGCCGGGAGCTG	0.697			NA	T	PBX1|HLF|TFPT	pre B-ALL								4	10					0	0	0.009096	0	0
ZNF676	163223	broad.mit.edu	37	19	22363197	22363197	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr19:22363197C>G	uc002nqs.1	-	3	1640	c.1322G>C	c.(1321-1323)AGA>ACA	p.R441T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGCATGAATTCTCTTGTGTTC	0.438			NA											32	67					0	0	0.013726	0	0
ZNF419	79744	broad.mit.edu	37	19	58005450	58005450	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr19:58005450A>T	uc002qov.2	+	5	1765	c.1525A>T	c.(1525-1527)ATG>TTG	p.M509L	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.M510L|ZNF419_uc010etz.1_Missense_Mutation_p.M497L|ZNF419_uc010eua.1_Missense_Mutation_p.M496L|ZNF419_uc002qow.2_Missense_Mutation_p.M477L|ZNF419_uc010eub.1_Missense_Mutation_p.M464L|ZNF419_uc010euc.1_Missense_Mutation_p.M463L	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		CACTGGAGAAATGCAGTGATT	0.428			NA											37	76					0	0	0.021022	0	0
ALK	238	broad.mit.edu	37	2	29456482	29456482	+	Silent	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr2:29456482A>G	uc002rmy.2	-	14	3343	c.2436T>C	c.(2434-2436)CAT>CAC	p.H812H		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	812	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTGCCCACTCATGCACGCTTC	0.488			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				8	112					0	0	0.00308	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290277	132290277	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr2:132290277C>T	uc002tta.2	+	5	851	c.799C>T	c.(799-801)CGA>TGA	p.R267*	CCDC74A_uc002ttb.2_Nonsense_Mutation_p.R201*	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	267										skin(1)	1						CCTTCCCCTGCGAAAGCCCAC	0.642			NA											4	104					0	0	0.009096	0	0
XIRP2	129446	broad.mit.edu	37	2	168100136	168100136	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr2:168100136G>C	uc002udx.2	+	8	2252	c.2234G>C	c.(2233-2235)AGA>ACA	p.R745T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R570T|XIRP2_uc010fpq.2_Missense_Mutation_p.R523T|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	570					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TATGTTATTAGAGATGGTTCG	0.383			NA											24	53					0	0	0.016522	0	0
SNTA1	6640	broad.mit.edu	37	20	31996581	31996581	+	Missense_Mutation	SNP	C	C	T	rs148604302		TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr20:31996581C>T	uc002wzd.1	-	7	1623	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K	SNTA1_uc010zuf.1_Missense_Mutation_p.E376K	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	451	SU.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						TGCAGCTTCTCGAAGGGCTGT	0.612			NA											38	62					0	0	0.005524	0	0
JPH2	57158	broad.mit.edu	37	20	42814998	42814998	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr20:42814998G>A	uc002xli.1	-	1	1221	c.348C>T	c.(346-348)GAC>GAT	p.D116D	JPH2_uc002xlj.2_Silent_p.D116D	NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	116	MORN 5.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGCCATAGCCGTCTTGCAGGC	0.632			NA											10	34					0	0	0.006214	0	0
RFPL3	10738	broad.mit.edu	37	22	32754215	32754215	+	Silent	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr22:32754215C>T	uc003amj.2	+	1	362	c.157C>T	c.(157-159)CTG>TTG	p.L53L	RFPL3_uc010gwn.2_Silent_p.L24L	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	53	RING-type.						zinc ion binding			ovary(1)	1						ACCAATGTCCCTGGAGTGTGG	0.537			NA											23	26					0	0	0.016522	0	0
KCNH8	131096	broad.mit.edu	37	3	19479843	19479843	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr3:19479843G>A	uc003cbk.1	+	8	1560	c.1365G>A	c.(1363-1365)ATG>ATA	p.M455I	KCNH8_uc011awe.1_Missense_Mutation_p.M455I|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_Missense_Mutation_p.M86I	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	455	Helical; Name=Segment S6; (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TCTGCACCATGCTGATTGGTG	0.458	NSCLC(124;1625 1765 8018 24930 42026)		NA											13	19					0	0	0.016723	0	0
ULK4	54986	broad.mit.edu	37	3	41497018	41497018	+	Silent	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr3:41497018C>T	uc003ckv.3	-	34	3663	c.3462G>A	c.(3460-3462)CTG>CTA	p.L1154L		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	1154	HEAT 4.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCAGGTCTGTCAGAGGTCTGT	0.478			NA											4	88					0	0	0.009096	0	0
KALRN	8997	broad.mit.edu	37	3	124045016	124045016	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr3:124045016C>A	uc003ehg.2	+	7	1403	c.1276C>A	c.(1276-1278)CAG>AAG	p.Q426K	KALRN_uc010hrv.1_Missense_Mutation_p.Q426K|KALRN_uc003ehf.1_Missense_Mutation_p.Q426K|KALRN_uc011bjy.1_Missense_Mutation_p.Q426K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	426					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GAAGGCTGAGCAGGTAAGGTG	0.602			NA											11	29					3.86212e-05	4.31893e-05	0.008291	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906262	164906262	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr3:164906262C>T	uc003fej.3	-	2	2801	c.2357G>A	c.(2356-2358)GGA>GAA	p.G786E	SLITRK3_uc003fek.2_Missense_Mutation_p.G786E	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	786	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTCACCCATTCCCGGTGGTTG	0.562			NA								HNSCC(40;0.11)			30	56					0	0	0.017118	0	0
BMPR1B	658	broad.mit.edu	37	4	96075720	96075720	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr4:96075720C>A	uc003htm.3	+	13	1679	c.1405C>A	c.(1405-1407)CTC>ATC	p.L469I	BMPR1B_uc010ilb.2_Missense_Mutation_p.L469I|BMPR1B_uc003htn.3_Missense_Mutation_p.L469I	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	469	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		GATGGGAAAACTCATGACAGA	0.433			NA											11	53					0.000978159	0.00105967	0.010729	1	0
SRD5A1	6715	broad.mit.edu	37	5	6663010	6663010	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:6663010C>T	uc003jdw.2	+	4	834	c.644C>T	c.(643-645)TCT>TTT	p.S215F	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.S168F	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	215	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	GCCAGCTGGTCTGTCCAAGGC	0.418			NA											24	191					0	0	0.01892	0	0
SRD5A1	6715	broad.mit.edu	37	5	6663031	6663031	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:6663031C>T	uc003jdw.2	+	4	855	c.665C>T	c.(664-666)GCT>GTT	p.A222V	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.A175V	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	222	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	GCGGCTTTTGCTTTCTTCACG	0.393			NA											25	170					0	0	0.021523	0	0
AFF4	27125	broad.mit.edu	37	5	132269967	132269967	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:132269967C>T	uc003kyd.2	-	3	1198	c.790G>A	c.(790-792)GAG>AAG	p.E264K	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.E264K|AFF4_uc003kyf.3_Missense_Mutation_p.E264K	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	264	Ser-rich.			E -> G (in Ref. 2; AAM00184).	transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCATGGACTCCTGTCCGTCC	0.517	Ovarian(126;889 1733 2942 10745 11605)		NA											16	63					0	0	0.004007	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502489	140502489	+	Silent	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:140502489A>G	uc003lip.1	+	1	909	c.909A>G	c.(907-909)AAA>AAG	p.K303K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	303	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACTGTTGAAAAAAAAATTGG	0.373			NA											77	145					0	0	0.01441	0	0
GABRA1	2554	broad.mit.edu	37	5	161324267	161324267	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:161324267A>G	uc010jiw.2	+	11	1678	c.1210A>G	c.(1210-1212)ACA>GCA	p.T404A	GABRA1_uc010jix.2_Missense_Mutation_p.T404A|GABRA1_uc010jiy.2_Missense_Mutation_p.T404A|GABRA1_uc003lyx.3_Missense_Mutation_p.T404A|GABRA1_uc010jiz.2_Missense_Mutation_p.T404A|GABRA1_uc010jja.2_Missense_Mutation_p.T404A|GABRA1_uc010jjb.2_Missense_Mutation_p.T404A	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	404	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CAAGCCCGAAACAAAACCACC	0.468			NA											8	119					0	0	0.00308	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32918372	32918372	+	Silent	SNP	T	T	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr6:32918372T>C	uc003ocm.2	-	2	383	c.297A>G	c.(295-297)TTA>TTG	p.L99L	HLA-DMA_uc011dqm.1_Silent_p.L99L	NM_006120	NP_006111	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM	99						integral to membrane|MHC class II protein complex					0						CTTTGTCAAATAAAATGGCAG	0.507			NA											58	117					0	0	0.01441	0	0
DSE	29940	broad.mit.edu	37	6	116757414	116757414	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr6:116757414G>T	uc003pws.2	+	6	1977	c.1783G>T	c.(1783-1785)GAG>TAG	p.E595*	DSE_uc011ebg.1_Nonsense_Mutation_p.E614*|DSE_uc003pwt.2_Nonsense_Mutation_p.E595*|DSE_uc003pwu.2_Nonsense_Mutation_p.E262*	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	595					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TGTTCCTTTTGAGGAGACTGT	0.493			NA											10	30					2.80697e-09	3.35546e-09	0.010729	1	0
SHPRH	257218	broad.mit.edu	37	6	146275957	146275957	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr6:146275957T>C	uc003qlf.2	-	2	901	c.502A>G	c.(502-504)ATG>GTG	p.M168V	SHPRH_uc003qld.2_Missense_Mutation_p.M168V|SHPRH_uc003qle.2_Missense_Mutation_p.M168V|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.M57V|SHPRH_uc003qlk.1_Missense_Mutation_p.M168V	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	168					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CAAATACTCATCGGTTCTTTT	0.368			NA											33	31					0	0	0.017118	0	0
SYNE1	23345	broad.mit.edu	37	6	152510398	152510398	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr6:152510398G>A	uc010kiw.2	-	128	23892	c.23290C>T	c.(23290-23292)CTA>TTA	p.L7764L	SYNE1_uc010kiv.2_Silent_p.L2288L|SYNE1_uc003qos.3_Silent_p.L2288L|SYNE1_uc003qot.3_Silent_p.L7693L|SYNE1_uc003qou.3_Silent_p.L7764L|SYNE1_uc003qoq.3_5'UTR|SYNE1_uc003qor.3_Silent_p.L664L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7764	Cytoplasmic (Potential).|Spectrin 26.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTGGCATAGTTCTTCCCAC	0.433			NA								HNSCC(10;0.0054)			6	113					0	0	0.001984	0	0
WTAP	9589	broad.mit.edu	37	6	160169299	160169299	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr6:160169299T>A	uc003qsl.2	+	6	572	c.350T>A	c.(349-351)ATC>AAC	p.I117N	WTAP_uc010kjx.2_Missense_Mutation_p.I117N|WTAP_uc003qsk.2_Missense_Mutation_p.I117N|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Missense_Mutation_p.I117N	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	117					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GACCCAGCGATCAACTTGTTT	0.438			NA											16	18					0	0	0.004007	0	0
OGDH	4967	broad.mit.edu	37	7	44733543	44733543	+	Silent	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr7:44733543C>T	uc003tln.2	+	11	1564	c.1455C>T	c.(1453-1455)TAC>TAT	p.Y485Y	OGDH_uc011kbx.1_Silent_p.Y481Y|OGDH_uc011kby.1_Silent_p.Y335Y|OGDH_uc003tlp.2_Silent_p.Y496Y|OGDH_uc011kbz.1_Silent_p.Y280Y|OGDH_uc003tlo.1_Silent_p.Y318Y	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	485					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CTGTCATGTACGTGTGCAAAG	0.612			NA											3	40					0	0	0.004672	0	0
PCLO	27445	broad.mit.edu	37	7	82544173	82544173	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr7:82544173C>T	uc003uhx.2	-	7	13418	c.13129G>A	c.(13129-13131)GCA>ACA	p.A4377T	PCLO_uc003uhv.2_Missense_Mutation_p.A4377T|PCLO_uc010lec.2_Missense_Mutation_p.A1342T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4308					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGTCCAGCTGCAGCCCTGGCC	0.502			NA											22	53					0	0	0.01892	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97949602	97949602	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr7:97949602G>C	uc003upj.2	-	4	486	c.223C>G	c.(223-225)CTC>GTC	p.L75V		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	75	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			ATCTCTATGAGGACATGTCCT	0.294			NA											15	51					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	7	124116875	124116875	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr7:124116875G>T	uc011kod.1	+	1	451	c.451G>T	c.(451-453)GGA>TGA	p.G151*		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;												NA						TGCCATCCTGGGAGCTTTCCT	0.532			NA											12	52					2.61681e-11	3.23987e-11	0.020292	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497387	1497387	+	Silent	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:1497387C>A	uc003wpl.2	+	2	625	c.528C>A	c.(526-528)GGC>GGA	p.G176G	DLGAP2_uc003wpm.2_Silent_p.G176G	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	255					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGCCAACGGCACCAAGGCGG	0.677			NA											4	4					0.00909568	0.00945951	0.009096	1	0
SNAI2	6591	broad.mit.edu	37	8	49832627	49832627	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:49832627G>A	uc003xqp.2	-	2	617	c.453C>T	c.(451-453)TGC>TGT	p.C151C		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	151					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				ACTGGGCATCGCAGTGCAGCT	0.453			NA											49	70					0	0	0.01441	0	0
NPBWR1	2831	broad.mit.edu	37	8	53852850	53852850	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:53852850C>T	uc011ldu.1	+	1	383	c.383C>T	c.(382-384)ACC>ATC	p.T128I		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	128	Helical; Name=3; (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				TACTTCCTCACCGTCATGAGC	0.677			NA											10	19					0	0	0.008291	0	0
PREX2	80243	broad.mit.edu	37	8	68931805	68931805	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:68931805G>C	uc003xxv.1	+	3	262	c.235G>C	c.(235-237)GAC>CAC	p.D79H	PREX2_uc003xxu.1_Missense_Mutation_p.D79H|PREX2_uc011lez.1_Intron	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	79	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AAACATTGAAGACATCCTTGC	0.358			NA											6	32					0	0	0.001168	0	0
KCNB2	9312	broad.mit.edu	37	8	73849192	73849192	+	Silent	SNP	T	T	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:73849192T>C	uc003xzb.2	+	3	2190	c.1602T>C	c.(1600-1602)CAT>CAC	p.H534H		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	534	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GCCCACAGCATCTGAGTGCCC	0.488			NA											5	100					0	0	0.014758	0	0
DCAF13	25879	broad.mit.edu	37	8	104442853	104442853	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:104442853G>A	uc003yln.2	+	6	1371	c.1094G>A	c.(1093-1095)GGA>GAA	p.G365E	DCAF13_uc003ylm.1_Missense_Mutation_p.G98E|DCAF13_uc003ylo.2_Missense_Mutation_p.G76E	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	213	WD 4.				rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						TTTCTCTTGGGAAGTTGTGCA	0.378			NA											99	260					0	0	0.01441	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999137	143999137	+	Silent	SNP	G	G	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:143999137G>T	uc003yxk.1	-	1	123	c.120C>A	c.(118-120)GCC>GCA	p.A40A		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	40					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCTGGGGCATGGCTTCAAACG	0.652			NA							Familial_Hyperaldosteronism_type_I				17	73					1.67942e-08	1.98476e-08	0.006122	1	0
CPSF1	29894	broad.mit.edu	37	8	145626466	145626466	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:145626466C>T	uc003zcj.2	-	6	466	c.391G>A	c.(391-393)GGG>AGG	p.G131R	CPSF1_uc003zck.1_Missense_Mutation_p.G53R|CPSF1_uc011lle.1_Missense_Mutation_p.G131R|MIR1234_hsa-mir-1234|MI0006324_5'Flank|CPSF1_uc011llf.1_Missense_Mutation_p.G131R	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	131					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TGCACAAACCCGTCCTGGGGG	0.677	NSCLC(133;1088 1848 27708 34777 35269)		NA											4	24					0	0	0.009096	0	0
RLN1	6013	broad.mit.edu	37	9	5335488	5335488	+	Silent	SNP	T	T	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:5335488T>A	uc003zjb.1	-	2	448	c.321A>T	c.(319-321)CCA>CCT	p.P107P		NM_006911	NP_008842	P04808	REL1_HUMAN	relaxin 1 preproprotein	107					female pregnancy|signal transduction	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		CTGGTAATGATGGTTGCCTCT	0.398			NA											29	395					0	0	0.00632	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007361	6007361	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:6007361C>G	uc003zjq.3	-	1	643	c.427G>C	c.(427-429)GAA>CAA	p.E143Q		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	143										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AACTTCTCTTCCATCTGCAGC	0.692			NA											37	38					0	0	0.019004	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007387	6007387	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:6007387C>T	uc003zjq.3	-	1	617	c.401G>A	c.(400-402)GGA>GAA	p.G134E		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	134										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CATGCCCTGTCCGGGCTGCTG	0.692			NA											21	25					0	0	0.012319	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007613	6007613	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:6007613C>G	uc003zjq.3	-	1	391	c.175G>C	c.(175-177)GAG>CAG	p.E59Q		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	59										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		GCCTCCATCTCTTCCTCCTGA	0.662			NA											39	65					0	0	0.00874	0	0
UBAP2	55833	broad.mit.edu	37	9	33998823	33998823	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:33998823C>T	uc003ztq.1	-	3	252	c.139G>A	c.(139-141)GAT>AAT	p.D47N	UBAP2_uc011loc.1_Missense_Mutation_p.D9N|UBAP2_uc011lod.1_5'UTR|UBAP2_uc011loe.1_Missense_Mutation_p.D9N|UBAP2_uc011lof.1_Missense_Mutation_p.D9N|UBAP2_uc011log.1_Missense_Mutation_p.D46N|UBAP2_uc003ztr.2_Missense_Mutation_p.D9N	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	47										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TCATTCTTATCAAAGATCACT	0.328			NA											18	135					0	0	0.014323	0	0
OR2S2	56656	broad.mit.edu	37	9	35957732	35957732	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr9:35957732C>G	uc011lpi.1	-	1	420	c.364G>C	c.(364-366)GAT>CAT	p.D122H		NM_019897	NP_063950	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			ACATAGCGATCAAATGCCATC	0.562	Pancreas(172;293 2036 17878 24427 30946)		NA											24	43					0	0	0.021523	0	0
PJA1	64219	broad.mit.edu	37	X	68381893	68381893	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chrX:68381893G>A	uc004dxh.2	-	2	1475	c.1189C>T	c.(1189-1191)CCG>TCG	p.P397S	PJA1_uc011mpi.1_Missense_Mutation_p.P115S|PJA1_uc004dxg.2_Missense_Mutation_p.P209S|PJA1_uc004dxi.2_Missense_Mutation_p.P342S	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	397							zinc ion binding				0						TCTTTCCCCGGCAGAGTCTCC	0.622			NA											3	45					0	0	0.009096	0	0
TAF1	6872	broad.mit.edu	37	X	70598123	70598123	+	Silent	SNP	A	A	G	rs55836865		TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chrX:70598123A>G	uc004dzu.3	+	7	1020	c.969A>G	c.(967-969)CAA>CAG	p.Q323Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.Q344Q	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	323	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AATTTTCCCAATCAACTGGAG	0.473			NA											3	56					0	0	0.009096	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433189	72433189	+	Silent	SNP	G	G	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chrX:72433189G>A	uc004ebi.2	-	1	1496	c.1140C>T	c.(1138-1140)ACC>ACT	p.T380T	NAP1L2_uc011mqj.1_Silent_p.T238T	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	380					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TTCCATTTGAGGTGATTCCAT	0.363			NA											46	15					0	0	0.013114	0	0
IRS4	8471	broad.mit.edu	37	X	107976069	107976069	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chrX:107976069G>C	uc004eoc.2	-	1	3539	c.3506C>G	c.(3505-3507)GCT>GGT	p.A1169G		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1169	Ala-rich.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGCATCAGCAGCATTAGCAAC	0.642			NA											80	14					0	0	0.01441	0	0
MTMR1	8776	broad.mit.edu	37	X	149901147	149901147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chrX:149901147C>A	uc004fei.2	+	9	1136	c.1001C>A	c.(1000-1002)TCA>TAA	p.S334*	MTMR1_uc011mya.1_Nonsense_Mutation_p.S240*|MTMR1_uc004feg.1_Nonsense_Mutation_p.S334*|MTMR1_uc004feh.1_Nonsense_Mutation_p.S342*|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	334	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AACGCACAGTCACACAAGCTT	0.423			NA											39	13					1.03484e-13	1.29666e-13	0.005524	1	0
R3HDM2	22864	broad.mit.edu	37	12	57674205	57674207	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	TGC	TGC	-	-	TGC	TGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr12:57674205_57674207delTGC	uc009zpm.1	-	12	1271_1273	c.1236_1238delGCA	c.(1234-1239)CAGCAA>CAA	p.412_413QQ>Q	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_In_Frame_Del_p.73_74QQ>Q|R3HDM2_uc001snr.2_In_Frame_Del_p.139_140QQ>Q|R3HDM2_uc001sns.2_In_Frame_Del_p.412_413QQ>Q|R3HDM2_uc001snt.2_In_Frame_Del_p.426_427QQ>Q|R3HDM2_uc009zpn.1_In_Frame_Del_p.35_36QQ>Q	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	412_413	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						AGCAGGAAGTtgctgctgctgct	0.488			NA											7	125	---	---	---	---	NA	NA	NA	NA	NA
SLC34A2	10568	broad.mit.edu	37	4	25677981	25677983	+	In_Frame_Del	DEL	CGT	CGT	-			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	CGT	CGT	-	-	CGT	CGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr4:25677981_25677983delCGT	uc003grr.2	+	13	1764_1766	c.1683_1685delCGT	c.(1681-1686)CCCGTC>CCC	p.V563del	SLC34A2_uc003grs.2_In_Frame_Del_p.V562del|SLC34A2_uc010iev.2_In_Frame_Del_p.V562del	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	563	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TCGGGGTTCCCGTCGTCTTCATC	0.606			NA											38	70	---	---	---	---	NA	NA	NA	NA	NA
CKMT2	1160	broad.mit.edu	37	5	80550291	80550292	+	Frame_Shift_Ins	INS	-	-	GG	rs146777847	byFrequency	TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr5:80550291_80550292insGG	uc003khc.3	+	5	670_671	c.428_429insGG	c.(427-429)ACGfs	p.T143fs	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Frame_Shift_Ins_p.T143fs|CKMT2_uc003khd.3_Frame_Shift_Ins_p.T143fs|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	143					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	AAGCACACAACGGATCTGGATG	0.569			NA											10	78	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55242465	55242479	+	In_Frame_Del	DEL	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	-	rs121913421		TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	-	-	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr7:55242465_55242479delGGAATTAAGAGAAGC	uc003tqk.2	+	19	2481_2495	c.2235_2249delGGAATTAAGAGAAGC	c.(2233-2250)AAGGAATTAAGAGAAGCA>AAA	p.ELREA746del	EGFR_uc010kzg.1_In_Frame_Del_p.ELREA701del|EGFR_uc011kco.1_In_Frame_Del_p.ELREA693del	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	746_750	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1613)|p.L747_P753>S(110)|p.L747_A750>P(74)|p.E746_S752>V(67)|p.L747_T751del(62)|p.E746_T751>A(30)|p.L747_S752del(28)|p.L747_T751>P(20)|p.E746_T751del(18)|p.L747_E749del(18)|p.K745_E749del(14)|p.E746_E749del(12)|p.E746_S752del(10)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.E746_P753>VS(6)|p.E746_A750>IP(5)|p.L747_T751>Q(5)|p.E746_T751>I(5)|p.E746_T751>V(5)|p.E746_S752>A(5)|p.E746_T751>IP(5)|p.E746_A750>QP(4)|p.E746V(4)|p.E746_S752>D(4)|p.K745_A750del(4)|p.L747S(3)|p.L747_S752>Q(3)|p.A750P(3)|p.E746_T751>VA(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.E746_A750>S(2)|p.E746_S752>T(2)|p.A750_E758>P(2)|p.E746_T751>Q(2)|p.E746_T751>S(2)|p.E746_A750>DP(2)|p.E746_T751>L(2)|p.E746K(2)|p.E746_P753del(2)|p.E746_S752>I(2)|p.K745_E746insVPVAIK(2)|p.E746_A750>AP(2)|p.L747_K754>ST(1)|p.E746_A750>A(1)|p.E746_T751>P(1)|p.E746del(1)|p.A750_K754del(1)|p.L747_S752>QH(1)|p.L747P(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.L747_R748>FP(1)|p.K745_L747del(1)|p.L747_T751>A(1)|p.E746_P753>LS(1)|p.E746_P753>VQ(1)|p.E746_T751>LS(1)|p.A750_E758del(1)|p.E746_R748del(1)|p.I744_A750>VK(1)|p.E746I(1)|p.L747_K754del(1)|p.R748I(1)|p.E746_A750>KP(1)|p.E746_A750>EP(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCGCTATCAAGGAATTAAGAGAAGCAACATCTCCG	0.479		E746_A750del(NCIH1650_LUNG)|E746K(HCC827_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	50	---	---	---	---	NA	NA	NA	NA	NA
KCNQ3	3786	broad.mit.edu	37	8	133150232	133150233	+	Frame_Shift_Ins	INS	-	-	T			TCGA-75-6207-01A-11D-1753-08	TCGA-75-6207-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a49e3fd-a47d-4b7d-9485-4238a88f4516	77398ded-5ae4-46fd-ac4a-a8b278586dd9	g.chr8:133150232_133150233insT	uc003ytj.2	-	12	1824_1825	c.1599_1600insA	c.(1597-1602)AAATTCfs	p.K533fs	KCNQ3_uc010mdt.2_Frame_Shift_Ins_p.K533fs	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	533_534					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTCTCCTTGAATTTTTTTTTAT	0.455			NA											7	233	---	---	---	---	NA	NA	NA	NA	NA
