Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATAD3A	55210	broad.mit.edu	37	1	1464630	1464630	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:1464630C>T	uc001afz.1	+	15	1771	c.1677C>T	c.(1675-1677)TAC>TAT	p.Y559Y	ATAD3A_uc001aga.1_Silent_p.Y511Y|ATAD3A_uc001agb.1_Silent_p.Y432Y|ATAD3A_uc001agc.1_5'Flank	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	559							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		AGTTTGACTACGGGAGGAAGT	0.672			NA											4	10					0	0	0.004482	0	0
MST1P9	11223	broad.mit.edu	37	1	17085872	17085872	+	Missense_Mutation	SNP	A	A	G	rs1806514	by1000genomes	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:17085872A>G	uc010ock.1	-	8	949	c.949T>C	c.(949-951)TGG>CGG	p.W317R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TCGAGGTTCCAGCAGAAGTTC	0.662			NA											3	18					0	0	0.00308	0	0
AKR7A2	8574	broad.mit.edu	37	1	19632530	19632530	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:19632530G>C	uc001bbw.2	-	6	922	c.900C>G	c.(898-900)TAC>TAG	p.Y300*	AKR7A2_uc001bbx.2_Nonsense_Mutation_p.Y265*	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2	300					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTGAGTGGTGGTACATCCACC	0.617			NA											35	45					0	0	0.003271	0	0
ARID1A	8289	broad.mit.edu	37	1	27092806	27092806	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:27092806C>A	uc001bmv.1	+	9	3200	c.2827C>A	c.(2827-2829)CCT>ACT	p.P943T	ARID1A_uc001bmt.1_Missense_Mutation_p.P943T|ARID1A_uc001bmu.1_Missense_Mutation_p.P943T|ARID1A_uc001bmw.1_Missense_Mutation_p.P560T	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	943					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CATGATCAACCCTCAGGGACC	0.498			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								29	68					1.12875e-08	1.22511e-08	0.00632	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74507000	74507000	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:74507000C>T	uc001dfy.3	-	7	1807	c.1615G>A	c.(1615-1617)GAG>AAG	p.E539K	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	539										ovary(2)	2						TCATTCTTCTCCAGTCTGTCA	0.318			NA											36	62					0	0	0.00623	0	0
TTLL7	79739	broad.mit.edu	37	1	84417596	84417596	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:84417596C>A	uc001djc.2	-	3	485	c.89G>T	c.(88-90)AGG>ATG	p.R30M	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	30					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TCTGACTTTCCTTTTCATTGT	0.353			NA											20	75					4.63292e-17	5.91861e-17	0.008871	1	0
TCHH	7062	broad.mit.edu	37	1	152080436	152080436	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:152080436C>G	uc001ezp.2	-	2	5257	c.5257G>C	c.(5257-5259)GAG>CAG	p.E1753Q	TCHH_uc009wne.1_Missense_Mutation_p.E1753Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1753	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGGAGCTGCTCTTCCTCTAGG	0.582			NA											34	111					0	0	0.010818	0	0
KCNJ10	3766	broad.mit.edu	37	1	160012237	160012237	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:160012237C>T	uc001fuw.1	-	2	236	c.86G>A	c.(85-87)AGA>AAA	p.R29K		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	29	Cytoplasmic (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTCAGGACTCTCCGCCGTCG	0.542	GBM(167;1368 2014 14817 36425 43215)		NA											18	129					0	0	0.006122	0	0
TNN	63923	broad.mit.edu	37	1	175116204	175116204	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:175116204C>T	uc001gkl.1	+	19	4010	c.3897C>T	c.(3895-3897)TTC>TTT	p.F1299F		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1299					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGCGAACGTTCTGATGGCCCG	0.607			NA									OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	42					0	0	0.00499	0	0
PAPPA2	60676	broad.mit.edu	37	1	176762762	176762762	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:176762762C>G	uc001gkz.2	+	20	6251	c.5087C>G	c.(5086-5088)ACT>AGT	p.T1696S	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1696	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAGAATATCACTGCTGACACT	0.493			NA											59	111					0	0	0.01441	0	0
RGS13	6003	broad.mit.edu	37	1	192627430	192627430	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:192627430G>T	uc001gsj.2	+	6	508	c.227G>T	c.(226-228)CGG>CTG	p.R76L	RGS13_uc001gsk.2_Missense_Mutation_p.R76L	NM_002927	NP_002918	O14921	RGS13_HUMAN	regulator of G-protein signalling 13	76	RGS.					plasma membrane	GTPase activator activity|signal transducer activity				0						ATTGCCTCACGGTGGAGCAGA	0.413			NA											27	69					8.24728e-16	1.0101e-15	0.004656	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204433650	204433650	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:204433650C>A	uc001haw.2	-	5	1596	c.1117G>T	c.(1117-1119)GGG>TGG	p.G373W	PIK3C2B_uc010pqv.1_Missense_Mutation_p.G373W|PIK3C2B_uc001hax.1_Missense_Mutation_p.G373W|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	373					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			ACCTCATCCCCGAGGTGCTCT	0.522			NA											40	98					1.32136e-16	1.64861e-16	0.00874	1	0
RAB3GAP2	25782	broad.mit.edu	37	1	220363423	220363423	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:220363423G>T	uc010puk.1	-	16	1861	c.1697C>A	c.(1696-1698)ACA>AAA	p.T566K	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.T146K	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	566					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		GGGAGATTTTGTTTTCAGTAA	0.308			NA											15	72					5.01169e-05	5.10734e-05	0.00499	1	0
C1orf131	128061	broad.mit.edu	37	1	231362496	231362496	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:231362496C>T	uc001hun.1	-	5	719	c.682G>A	c.(682-684)GAA>AAA	p.E228K	C1orf131_uc001hul.2_Missense_Mutation_p.E228K|C1orf131_uc001hum.2_Missense_Mutation_p.E227K|C1orf131_uc010pwd.1_Missense_Mutation_p.E227K	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	228	Lys-rich.									central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				AGTCTCTTTTCTTCTTCCTTT	0.408			NA											23	167					0	0	0.00278	0	0
RYR2	6262	broad.mit.edu	37	1	237620026	237620026	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:237620026G>T	uc001hyl.1	+	16	1723	c.1603G>T	c.(1603-1605)GAG>TAG	p.E535*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	535	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCTCTGTATGAGTTGCTGGG	0.363			NA											37	108					2.95478e-19	3.88633e-19	0.00874	1	0
FMN2	56776	broad.mit.edu	37	1	240370778	240370778	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:240370778C>T	uc010pyd.1	+	5	2891	c.2666C>T	c.(2665-2667)CCT>CTT	p.P889L	FMN2_uc010pye.1_Missense_Mutation_p.P893L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	889	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATGACAGTGCCTACTCTGCCC	0.642			NA											77	151					0	0	0.01441	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285994	248285994	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:248285994C>A	uc001idy.1	+	1	557	c.557C>A	c.(556-558)GCA>GAA	p.A186E		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TTCTATGGAGCAGGTTTGTTC	0.512			NA											77	232					3.83446e-41	5.62527e-41	0.01441	1	0
OR2T4	127074	broad.mit.edu	37	1	248525358	248525358	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr1:248525358G>T	uc001ieh.1	+	1	476	c.476G>T	c.(475-477)TGC>TTC	p.C159F		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	159	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGGCCATCTGCCATCCTCTC	0.532			NA											101	284					2.94851e-48	4.34945e-48	0.01441	1	0
CUBN	8029	broad.mit.edu	37	10	17130243	17130243	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr10:17130243T>A	uc001ioo.2	-	15	1919	c.1867A>T	c.(1867-1869)AGT>TGT	p.S623C		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	623	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGTCAGGACTAGTTACAACA	0.438			NA											43	61					0	0	0.011902	0	0
HIF1AN	55662	broad.mit.edu	37	10	102296366	102296366	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr10:102296366C>A	uc001krj.3	+	2	451	c.376C>A	c.(376-378)CAT>AAT	p.H126N		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	126	Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		AATGAAATTTCATGAGTTCGT	0.423			NA											19	72					1.67942e-08	1.8154e-08	0.006122	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118357378	118357378	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr10:118357378G>A	uc001lco.1	+	7	631	c.613G>A	c.(613-615)GAA>AAA	p.E205K	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.E205K|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	205		Calcium; via carbonyl oxygen.			lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GAGTACTCCTGAAGAGGTGCG	0.488			NA											23	57					0	0	0.014323	0	0
STIM1	6786	broad.mit.edu	37	11	3988901	3988901	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:3988901G>C	uc001lyv.2	+	2	827	c.259G>C	c.(259-261)GAA>CAA	p.E87Q	STIM1_uc009yef.2_Missense_Mutation_p.E87Q	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	87	Potential.|EF-hand.|Extracellular (Potential).			E->A,Q: Increases Ca(2+) influx through activation of CRAC channels, even when Ca(2+) stores are not depleted.	activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GGATGTGGAAGAAAGTGATGA	0.488			NA											16	67					0	0	0.00499	0	0
OR51A4	401666	broad.mit.edu	37	11	4967852	4967852	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:4967852G>T	uc010qys.1	-	1	479	c.479C>A	c.(478-480)CCC>CAC	p.P160H		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAAGGGAAGGGAAGAACCAG	0.443			NA											30	163					1.32136e-16	1.64861e-16	0.00874	1	0
OR51A2	401667	broad.mit.edu	37	11	4976465	4976465	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:4976465G>T	uc010qyt.1	-	1	479	c.479C>A	c.(478-480)CCC>CAC	p.P160H		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAAGGGAAGGGAAGAACCAG	0.443			NA											65	272					7.1157e-29	9.94707e-29	0.01441	1	0
ZNF214	7761	broad.mit.edu	37	11	7022697	7022697	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:7022697C>A	uc001mfa.2	-	3	520	c.217G>T	c.(217-219)GCT>TCT	p.A73S	ZNF214_uc010ray.1_Missense_Mutation_p.A73S|ZNF214_uc009yfh.1_Missense_Mutation_p.A73S	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TGGGCGCCAGCATTCCACCAG	0.413	Ovarian(22;251 657 736 21522 46864)		NA											136	159					2.23784e-72	3.3949e-72	0.01441	1	0
AMPD3	272	broad.mit.edu	37	11	10514898	10514898	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:10514898G>A	uc001mio.1	+	7	1277	c.942G>A	c.(940-942)GTG>GTA	p.V314V	AMPD3_uc010rbz.1_Silent_p.V155V|AMPD3_uc001min.1_Silent_p.V323V|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Silent_p.V321V|AMPD3_uc009yfy.2_Silent_p.V314V	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	314					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TGTTCCAGGTGGACACACACA	0.572			NA											29	130					0	0	0.010818	0	0
INSC	387755	broad.mit.edu	37	11	15134098	15134098	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:15134098G>T	uc001mly.2	+	1	129	c.83G>T	c.(82-84)AGG>ATG	p.R28M	INSC_uc001mlz.2_5'Flank	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	28					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GAGTCCAGGAGGCTGTGCTGT	0.478			NA											12	16					6.31663e-08	6.74616e-08	0.003163	1	0
INSC	387755	broad.mit.edu	37	11	15197423	15197423	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:15197423G>T	uc001mly.2	+	3	380	c.334G>T	c.(334-336)GCA>TCA	p.A112S	INSC_uc001mlz.2_Missense_Mutation_p.A65S|INSC_uc001mma.2_Missense_Mutation_p.A65S|INSC_uc010rcs.1_Missense_Mutation_p.A65S|INSC_uc001mmb.2_Missense_Mutation_p.A65S|INSC_uc001mmc.2_Missense_Mutation_p.A65S	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	112					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CCTCATCCTGGCAGGTGGCCC	0.617			NA											18	23					1.01871e-10	1.15743e-10	0.008871	1	0
RAG2	5897	broad.mit.edu	37	11	36615240	36615240	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:36615240G>T	uc001mwv.3	-	2	667	c.479C>A	c.(478-480)TCA>TAA	p.S160*	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	160					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				AGGCATGTATGAGCGTCCTCC	0.458			NA							Familial_Hemophagocytic_Lymphohistiocytosis				87	86					2.5264e-35	3.58803e-35	0.01441	1	0
MADD	8567	broad.mit.edu	37	11	47345827	47345827	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:47345827G>A	uc001ner.1	+	32	4745	c.4554G>A	c.(4552-4554)CTG>CTA	p.L1518L	MADD_uc001neq.2_Silent_p.L1459L|MADD_uc001nev.1_Silent_p.L1416L|MADD_uc001nes.1_Silent_p.L1436L|MADD_uc001net.1_Silent_p.L1479L|MADD_uc009yln.1_Silent_p.L1412L|MADD_uc001neu.1_Silent_p.L1416L|MADD_uc001nex.2_Silent_p.L1518L|MADD_uc001nez.2_Silent_p.L1415L|MADD_uc001new.2_Silent_p.L1458L|MADD_uc009ylo.2_Silent_p.L432L	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1518					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GTCGGGAGCTGTACTACTGTG	0.577			NA											9	37					0	0	0.010729	0	0
LOC440040	440040	broad.mit.edu	37	11	49598251	49598251	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:49598251A>T	uc010rhy.1	+	2	842	c.364A>T	c.(364-366)AGT>TGT	p.S122C	LOC440040_uc009ymb.2_Missense_Mutation_p.S122C	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						GCCTGGTTCCAGTTCTGTAGC	0.498			NA											19	25					0	0	0.014323	0	0
OR8H2	390151	broad.mit.edu	37	11	55872752	55872752	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:55872752C>T	uc010riy.1	+	1	234	c.234C>T	c.(232-234)GTC>GTT	p.V78V		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CAACTGTCGTCACACCTAAAA	0.428			NA								HNSCC(53;0.14)			106	408					0	0	0.01441	0	0
OR10W1	81341	broad.mit.edu	37	11	58035110	58035110	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:58035110G>T	uc001nmq.1	-	1	623	c.221C>A	c.(220-222)GCC>GAC	p.A74D		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	74	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TAGGGTGTTGGCCAGGATATG	0.517			NA											35	59					1.06647e-15	1.30022e-15	0.003755	1	0
SLC22A10	387775	broad.mit.edu	37	11	63057558	63057558	+	Translation_Start_Site	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:63057558A>G	uc009yor.2	+	1	129	c.-79A>G	c.(-81--77)ATAAA>ATGAA		SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_Intron|SLC22A10_uc010rmp.1_5'Flank	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10							integral to membrane	transmembrane transporter activity			ovary(2)	2						TTGAATTAATAAAAGGAAATA	0.443			NA											9	5					0	0	0.004482	0	0
MARK2	2011	broad.mit.edu	37	11	63668529	63668529	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:63668529C>G	uc001nxw.2	+	11	1668	c.1089C>G	c.(1087-1089)TAC>TAG	p.Y363*	MARK2_uc001nxx.2_Nonsense_Mutation_p.Y363*|MARK2_uc001nxy.2_Nonsense_Mutation_p.Y363*|MARK2_uc001nxv.3_Nonsense_Mutation_p.Y363*|MARK2_uc001nxz.3_Nonsense_Mutation_p.Y330*|MARK2_uc009yoy.2_Nonsense_Mutation_p.Y330*	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	363					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TCCTGGGCTACAAGAGCTCCG	0.572			NA											29	21					0	0	0.00632	0	0
NUDT22	84304	broad.mit.edu	37	11	63996792	63996792	+	Missense_Mutation	SNP	G	G	A	rs147573630		TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:63996792G>A	uc001nyp.3	+	4	833	c.653G>A	c.(652-654)CGA>CAA	p.R218Q	NUDT22_uc009ype.2_Missense_Mutation_p.R218Q|NUDT22_uc001nyq.3_Missense_Mutation_p.R185Q|NUDT22_uc010rng.1_RNA|uc001nyr.1_3'UTR|DNAJC4_uc001nys.2_5'Flank|DNAJC4_uc001nyt.2_5'Flank|DNAJC4_uc001nyu.2_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	218	Nudix hydrolase.						hydrolase activity				0						AGTGCTGGCCGAGCCAGTGCC	0.647			NA											3	8					0	0	0.004672	0	0
CHORDC1	26973	broad.mit.edu	37	11	89935685	89935685	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:89935685G>C	uc001pdg.2	-	11	1297	c.887C>G	c.(886-888)ACT>AGT	p.T296S	CHORDC1_uc009yvz.2_Missense_Mutation_p.T277S	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	296	Interaction with HSP90AA1 and HSP90AB1 (By similarity).|CS.				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				CTTTGTTGCAGTCATAGTTAC	0.383			NA											27	27					0	0	0.005443	0	0
FAT3	120114	broad.mit.edu	37	11	92088256	92088256	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:92088256G>T	uc001pdj.3	+	1	2995	c.2978G>T	c.(2977-2979)CGC>CTC	p.R993L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	993	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGCCATCCGCTTGAGCAAA	0.458			NA								TCGA Ovarian(4;0.039)			16	27					2.23348e-06	2.32039e-06	0.004007	1	0
FAT3	120114	broad.mit.edu	37	11	92534129	92534129	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:92534129C>T	uc001pdj.3	+	9	7967	c.7950C>T	c.(7948-7950)CTC>CTT	p.L2650L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2650	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGCCGACCTCCTGGAAATCG	0.453			NA								TCGA Ovarian(4;0.039)			12	15					0	0	0.010729	0	0
CDON	50937	broad.mit.edu	37	11	125891389	125891389	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:125891389G>T	uc009zbw.2	-	3	231	c.103C>A	c.(103-105)CCG>ACG	p.P35T	CDON_uc001qdc.3_Missense_Mutation_p.P35T|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.P35T	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	35	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GCAGAGAGCGGCTCAGAAGTA	0.438			NA											27	33					6.12954e-19	7.98335e-19	0.004656	1	0
NCAPD3	23310	broad.mit.edu	37	11	134079318	134079318	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr11:134079318C>A	uc001qhd.1	-	5	1227	c.621G>T	c.(619-621)CGG>CGT	p.R207R	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	207					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GAGAAAGGTCCCGGGCAGAAA	0.343			NA											37	35					6.90743e-12	8.01862e-12	0.003755	1	0
CLEC2B	9976	broad.mit.edu	37	12	10010225	10010225	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:10010225G>A	uc001qwn.2	-	3	742	c.85C>T	c.(85-87)CGA>TGA	p.R29*		NM_005127	NP_005118	Q92478	CLC2B_HUMAN	C-type lectin, superfamily member 2	29	Extracellular (Potential).					integral to plasma membrane	sugar binding				0						TGAGAATCTCGAGTTAGTTTA	0.318			NA											9	25					0	0	0.006214	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398285	+	Missense_Mutation	DNP	CC	CC	AA	rs121913529		TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:25398284_25398285CC>AA	uc001rgp.1	-	2	215_216	c.34_35GG>TT	c.(34-36)GGT>TTT	p.G12F	KRAS_uc001rgq.1_Missense_Mutation_p.G12F|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAACT	0.347	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(CALU1_LUNG)|G12V(PATU8988S_PANCREAS)|G12C(NCIH1792_LUNG)|G12D(SU8686_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12D(LS513_LARGE_INTESTINE)|G12D(PANC0203_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12C(HCC44_LUNG)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEC50B_ENDOMETRIUM)|G12V(NCIH2444_LUNG)|G12D(MCAS_OVARY)|G12D(ASPC1_PANCREAS)|G12V(SHP77_LUNG)|G12R(CAL62_THYROID)|G12D(HPAFII_PANCREAS)|G12A(NCIH2009_LUNG)|G12D(PANC0403_PANCREAS)|G12C(NCIH2030_LUNG)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(PANC0327_PANCREAS)|G12D(PANC0813_PANCREAS)|G12V(COLO668_LUNG)|G12V(NCIH441_LUNG)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12V(CAPAN2_PANCREAS)|G12R(HUPT3_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12R(HS274T_BREAST)|G12V(SW480_LARGE_INTESTINE)|G12V(QGP1_PANCREAS)|G12S(LS123_LARGE_INTESTINE)|G12C(SW837_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(RKN_OVARY)|G12C(IALM_LUNG)|G12C(UMUC3_URINARY_TRACT)|G12V(RERFLCAD2_LUNG)|G12C(LU99_LUNG)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12V(SH10TC_STOMACH)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12D(COLO678_LARGE_INTESTINE)|G12S(A549_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RERFLCAD1_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH1373_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12C(MIAPACA2_PANCREAS)|G12V(DANG_PANCREAS)|G12D(L33_PANCREAS)|G12C(OV56_OVARY)|G12V(PATU8902_PANCREAS)|G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12R(KP2_PANCREAS)|G12D(SUIT2_PANCREAS)|G12C(NCIH2122_LUNG)|G12D(KP4_PANCREAS)|G12C(NCIH358_LUNG)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12C(SW1463_LARGE_INTESTINE)|G12V(RCM1_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12D(PANC1_PANCREAS)|G12C(SW1573_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	16					0	0	0.004672	0	0
SMUG1	23583	broad.mit.edu	37	12	54576051	54576051	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:54576051C>A	uc001sff.1	-	4	771	c.642G>T	c.(640-642)GGG>GGT	p.G214G	SMUG1_uc001sfa.1_RNA|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Silent_p.G214G|SMUG1_uc009znf.1_Silent_p.G214G|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	214					depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						CTGCCAGTCGCCCAACTCCCA	0.667			NA						BER_DNA_glycosylases					32	53					5.60225e-13	6.58943e-13	0.009535	1	0
RPSAP52	204010	broad.mit.edu	37	12	66152274	66152274	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:66152274G>A	uc001sso.2	-	2	670	c.249C>T	c.(247-249)CTC>CTT	p.L83L		NR_026825				SubName: Full=Putative uncharacterized protein RPSAP52;												0						CTGACCCACTGAGGGAGCTCC	0.502			NA											9	31					0	0	0.006214	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72057061	72057061	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:72057061G>A	uc001swo.2	-	1	689	c.330C>T	c.(328-330)TTC>TTT	p.F110F	ZFC3H1_uc010sts.1_Silent_p.F110F|ZFC3H1_uc001swp.2_Silent_p.F110F|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	110	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GATGAGACCGGAACGGTTCTT	0.632			NA											17	122					0	0	0.006122	0	0
LUM	4060	broad.mit.edu	37	12	91502060	91502060	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:91502060A>T	uc001tbm.2	-	2	1086	c.697T>A	c.(697-699)TAT>AAT	p.Y233N	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	233	LRR 8.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						AAACGCAGATACTGCAATGCA	0.423			NA											64	55					0	0	0.01441	0	0
ACACB	32	broad.mit.edu	37	12	109671560	109671560	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:109671560G>C	uc001tob.2	+	30	4266	c.4147G>C	c.(4147-4149)GAT>CAT	p.D1383H	ACACB_uc001toc.2_Missense_Mutation_p.D1383H|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.D49H	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1383				D -> G (in Ref. 6; AAC50571).	acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CAGAAATTTTGATGAAGTCAT	0.597			NA											28	46					0	0	0.004656	0	0
TRPV4	59341	broad.mit.edu	37	12	110236638	110236638	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:110236638C>A	uc001tpj.1	-	5	1028	c.933G>T	c.(931-933)AAG>AAT	p.K311N	TRPV4_uc001tpg.1_Missense_Mutation_p.K277N|TRPV4_uc001tph.1_Missense_Mutation_p.K264N|TRPV4_uc001tpi.1_Missense_Mutation_p.K264N|TRPV4_uc001tpk.1_Missense_Mutation_p.K311N|TRPV4_uc001tpl.1_Missense_Mutation_p.K311N	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	311	Cytoplasmic (Potential).|ANK 2.				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GCATGTCCGCCTTCTTGTGGG	0.617			NA											13	60					1.49906e-05	1.53352e-05	0.00245	1	0
IQCD	115811	broad.mit.edu	37	12	113633461	113633461	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:113633461C>G	uc001tuu.2	-	3	1135	c.963G>C	c.(961-963)AAG>AAC	p.K321N		NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	Error:Variant_position_missing_in_Q96DY2_after_alignment										ovary(1)	1						cccgcttcttctTGGATCTGA	0.388			NA											35	77					0	0	0.004878	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184743	130184743	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr12:130184743C>A	uc009zyl.1	-	2	908	c.580G>T	c.(580-582)GCC>TCC	p.A194S		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	194	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCAGCTCGGCCACGCACAGC	0.706			NA											12	20					1.08611e-07	1.15076e-07	0.010729	1	0
BRCA2	675	broad.mit.edu	37	13	32912197	32912197	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:32912197A>G	uc001uub.1	+	11	3932	c.3705A>G	c.(3703-3705)CAA>CAG	p.Q1235Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1235	BRCA2 2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGCTCTGCAAAAAGCTGTGA	0.358	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			17	56					0	0	0.006122	0	0
COG3	83548	broad.mit.edu	37	13	46054349	46054349	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:46054349T>C	uc001vak.2	+	4	574	c.473T>C	c.(472-474)TTG>TCG	p.L158S	COG3_uc010tfu.1_RNA|COG3_uc001vai.2_Missense_Mutation_p.L158S|COG3_uc001vaj.1_Missense_Mutation_p.L158S|COG3_uc010tfv.1_Intron|COG3_uc010aci.2_Intron	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	158					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTGGAGTCTTTGCAGAAACAG	0.413	Ovarian(150;1048 1859 18083 21577 42700)		NA											19	56					0	0	0.007413	0	0
SIAH3	283514	broad.mit.edu	37	13	46358015	46358015	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:46358015A>G	uc001vap.2	-	2	395	c.313T>C	c.(313-315)TGC>CGC	p.C105R		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	105	SIAH-type; degenerate.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						ATGCACAGGCAGGGCGTCACC	0.453			NA											8	61					0	0	0.006214	0	0
CDADC1	81602	broad.mit.edu	37	13	49842173	49842173	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:49842173C>T	uc001vcu.2	+	5	1054	c.978C>T	c.(976-978)GCC>GCT	p.A326A	CDADC1_uc001vcs.1_RNA|CDADC1_uc001vct.1_Silent_p.A208A|CDADC1_uc010tgk.1_Silent_p.A128A|CDADC1_uc001vcv.2_RNA	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	326							hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		TGGTTCAGGCCAGGTTATTGG	0.403			NA											34	88					0	0	0.003755	0	0
WDFY2	115825	broad.mit.edu	37	13	52325503	52325503	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:52325503C>T	uc001vfp.2	+	8	1123	c.783C>T	c.(781-783)GGC>GGT	p.G261G	WDFY2_uc010ads.1_Silent_p.G261G|WDFY2_uc010adt.1_RNA	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	261	WD 6.						metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)		TCTCCTGTGGCGGTGATGGTG	0.572			NA											14	61					0	0	0.006122	0	0
DIS3	22894	broad.mit.edu	37	13	73336106	73336106	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:73336106C>A	uc001vix.3	-	17	2671	c.2297G>T	c.(2296-2298)GGC>GTC	p.G766V	DIS3_uc001viy.3_Missense_Mutation_p.G736V|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	766					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AGACGCTAAGCCATAGTGATG	0.328			NA								Multiple Myeloma(4;0.011)			68	35					9.4991e-31	1.33487e-30	0.01441	1	0
RNF113B	140432	broad.mit.edu	37	13	98828921	98828921	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:98828921A>T	uc001vnk.2	-	1	601	c.570T>A	c.(568-570)GAT>GAA	p.D190E	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	190	C3H1-type.						nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			CAGGCTGGTAATCCCAGCGCA	0.607			NA											76	33					0	0	0.01441	0	0
DCUN1D2	55208	broad.mit.edu	37	13	114138335	114138335	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr13:114138335G>A	uc001vtr.1	-	2	79	c.40C>T	c.(40-42)CAG>TAG	p.Q14*	DCUN1D2_uc001vts.1_RNA|DCUN1D2_uc010agw.1_Intron	NM_001014283	NP_001014305	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain	14	UBA-like.										0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			GCCATAAACTGGCGGACCTTG	0.502			NA											41	121					0	0	0.00623	0	0
CHD8	57680	broad.mit.edu	37	14	21862131	21862131	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:21862131C>A	uc001was.1	-	32	5080	c.4986G>T	c.(4984-4986)GGG>GGT	p.G1662G	CHD8_uc001war.1_Silent_p.G1558G|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1941					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTTGGCTCACCCCATGGCGGG	0.552			NA											28	32					1.75199e-13	2.07902e-13	0.007291	1	0
OR10G3	26533	broad.mit.edu	37	14	22038258	22038258	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:22038258C>T	uc010tmb.1	-	1	618	c.618G>A	c.(616-618)GTG>GTA	p.V206V		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		TGGCAACCACCACCCCAATGT	0.527			NA											69	96					0	0	0.01441	0	0
COCH	1690	broad.mit.edu	37	14	31344261	31344261	+	Splice_Site	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:31344261G>C	uc001wqr.2	+	3	115	c.35_splice	c.e3-1	p.G12_splice	COCH_uc001wqp.2_Splice_Site_p.G12_splice|COCH_uc001wqq.3_Splice_Site_p.G12_splice	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor						sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TCTCTTCGCAGGTGTGTGTCT	0.741			NA											6	12					0	0	0.001168	0	0
CFL2	1073	broad.mit.edu	37	14	35182111	35182111	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:35182111C>G	uc001wsg.3	-	4	602	c.461G>C	c.(460-462)GGA>GCA	p.G154A	CFL2_uc010tpn.1_Missense_Mutation_p.G137A|CFL2_uc001wsh.3_Missense_Mutation_p.G154A|CFL2_uc001wsi.3_RNA|CFL2_uc001wsj.3_RNA	NM_021914	NP_068733	Q9Y281	COF2_HUMAN	cofilin 2	154						cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(2)	2	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		TACATTGCCTCCCAATTTCTC	0.378			NA											26	81					0	0	0.00632	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724405	38724405	+	Missense_Mutation	SNP	T	T	C	rs140940981	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:38724405T>C	uc001wum.1	-	1	1170	c.823A>G	c.(823-825)ACG>GCG	p.T275A		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	275	Extracellular (Potential).|EGF-like.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCGAAGCCCGTAGCACATTCG	0.667			NA											18	145					0	0	0.00499	0	0
FSCB	84075	broad.mit.edu	37	14	44974569	44974569	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:44974569T>C	uc001wvn.2	-	1	1931	c.1622A>G	c.(1621-1623)GAA>GGA	p.E541G		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	541	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGACTGAGCTTCAGCAGGAGT	0.493			NA											8	48					0	0	0.004482	0	0
HSPA2	3306	broad.mit.edu	37	14	65008546	65008546	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:65008546G>T	uc001xhj.2	+	2	1055	c.979G>T	c.(979-981)GCC>TCC	p.A327S	HSPA2_uc001xhk.3_Missense_Mutation_p.A327S	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	327					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GCTGCGCGACGCCAAGCTGGA	0.622	Pancreas(136;1211 1835 24894 31984 38227)		NA											23	21					1.55795e-14	1.87375e-14	0.012319	1	0
ZFP36L1	677	broad.mit.edu	37	14	69256498	69256498	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:69256498C>T	uc001xkh.1	-	2	899	c.769G>A	c.(769-771)GAG>AAG	p.E257K	ZFP36L1_uc001xki.1_Missense_Mutation_p.E257K	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	257					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTTGCCAGCTCCTGGCTGGAG	0.632			NA									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	102					0	0	0.006122	0	0
KIAA1409	57578	broad.mit.edu	37	14	94083503	94083503	+	Silent	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:94083503T>C	uc001ybv.1	+	26	3695	c.3612T>C	c.(3610-3612)CTT>CTC	p.L1204L	KIAA1409_uc001ybs.1_Silent_p.L1182L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1359						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GAAAACACCTTCTCCCCTTAG	0.423			NA											36	101					0	0	0.005524	0	0
ATG2B	55102	broad.mit.edu	37	14	96808029	96808029	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:96808029G>A	uc001yfi.2	-	6	1119	c.754C>T	c.(754-756)CCA>TCA	p.P252S		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	252										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAGAGCTTTGGCTCAGTTTCC	0.299			NA											35	34					0	0	0.003755	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408595	105408595	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr14:105408595C>A	uc010axc.1	-	7	13313	c.13193G>T	c.(13192-13194)GGT>GTT	p.G4398V	AHNAK2_uc001ypx.2_Missense_Mutation_p.G4298V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4398						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TATCTGGGGACCCTTGAGGTC	0.602			NA											35	139					6.02846e-25	8.25435e-25	0.003271	1	0
MKRN3	7681	broad.mit.edu	37	15	23811531	23811531	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:23811531C>A	uc001ywh.3	+	1	1078	c.602C>A	c.(601-603)GCG>GAG	p.A201E	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.A201E	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	201						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAAGCTGGGCGGATGCCATT	0.592			NA											12	24					2.80697e-09	3.1098e-09	0.010729	1	0
GABRG3	2567	broad.mit.edu	37	15	27574019	27574019	+	Silent	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:27574019G>C	uc001zbg.1	+	5	724	c.558G>C	c.(556-558)CCG>CCC	p.P186P	GABRG3_uc001zbf.2_Silent_p.P186P	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	186	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ACTCCTGCCCGCTGATTTTCT	0.547	NSCLC(114;800 1656 7410 37729 45293)		NA											32	19					0	0	0.003755	0	0
RYR3	6263	broad.mit.edu	37	15	34137093	34137093	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:34137093G>A	uc001zhi.2	+	93	13397	c.13327G>A	c.(13327-13329)GAG>AAG	p.E4443K	RYR3_uc010bar.2_Missense_Mutation_p.E4438K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4443					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGAAGAGACAGAGGATGTTGC	0.443			NA											6	26					0	0	0.001984	0	0
ACTC1	70	broad.mit.edu	37	15	35084379	35084379	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:35084379C>T	uc001ziu.1	-	5	963	c.720G>A	c.(718-720)AAG>AAA	p.K240K	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	240					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GTTCATAGCTCTTCTCCAGGG	0.507			NA											35	20					0	0	0.003271	0	0
AP4E1	23431	broad.mit.edu	37	15	51291271	51291271	+	Silent	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:51291271G>T	uc001zyx.1	+	19	2937	c.2907G>T	c.(2905-2907)GTG>GTT	p.V969V	AP4E1_uc010bex.1_Intron	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	969					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		ATTTGCAGGTGACTGAGCAAC	0.363			NA											28	16					7.01153e-11	8.00034e-11	0.007291	1	0
MYO5C	55930	broad.mit.edu	37	15	52505478	52505478	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:52505478C>T	uc010bff.2	-	34	4185	c.4048G>A	c.(4048-4050)GAT>AAT	p.D1350N	MYO5C_uc010uga.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	1350	Potential.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		GAGTGCACATCATTGGCTGTA	0.473			NA											12	32					0	0	0.010729	0	0
ZNF280D	54816	broad.mit.edu	37	15	56974516	56974516	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:56974516C>A	uc002adu.2	-	10	1157	c.940G>T	c.(940-942)GAA>TAA	p.E314*	ZNF280D_uc002adv.2_Nonsense_Mutation_p.E301*|ZNF280D_uc010bfq.2_Nonsense_Mutation_p.E314*|ZNF280D_uc002adw.1_Nonsense_Mutation_p.E342*|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		GTCTTCTGTTCCTCCTGGACA	0.279			NA											10	28					2.80697e-09	3.1098e-09	0.010729	1	0
BNIP2	663	broad.mit.edu	37	15	59964843	59964843	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:59964843G>C	uc010uhc.1	-	6	934	c.931C>G	c.(931-933)CTT>GTT	p.L311V	BNIP2_uc010uhb.1_Missense_Mutation_p.L252V	NM_004330	NP_004321	Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 2	190	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1						TACTTAAAAAGATTGTCCATC	0.303	Ovarian(174;1936 1978 6671 8240 38212)		NA											16	44					0	0	0.004007	0	0
ISLR2	57611	broad.mit.edu	37	15	74426032	74426032	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:74426032C>A	uc002axd.2	+	4	1706	c.937C>A	c.(937-939)CAA>AAA	p.Q313K	ISLR2_uc002axe.2_Missense_Mutation_p.Q313K|ISLR2_uc010bjg.2_Missense_Mutation_p.Q313K|ISLR2_uc010bjf.2_Missense_Mutation_p.Q313K	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	313	Ig-like.|Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GACGCAGACCCAAGCCCAAAC	0.488			NA											5	11					1.23904e-05	1.2724e-05	0.000602	1	0
STARD5	80765	broad.mit.edu	37	15	81605687	81605687	+	Silent	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr15:81605687G>C	uc002bgm.2	-	6	636	c.552C>G	c.(550-552)CTC>CTG	p.L184L	STARD5_uc002bgn.2_Silent_p.L77L	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	184	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						CGTTCTGTGGGAGGTAACCGC	0.517			NA											28	72					0	0	0.010818	0	0
RHBDL1	9028	broad.mit.edu	37	16	728016	728016	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:728016C>T	uc002cis.1	+	7	1308	c.1281C>T	c.(1279-1281)TAC>TAT	p.Y427Y	RHBDL1_uc002cir.1_Silent_p.Y362Y|RHBDL1_uc010uun.1_3'UTR|STUB1_uc002cit.2_5'Flank|STUB1_uc002ciu.2_5'Flank|STUB1_uc010bqz.2_5'Flank|STUB1_uc002civ.2_5'Flank	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	427					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				TCTTCGCCTACGACCTGCTGG	0.701			NA											4	14					0	0	0.009096	0	0
PTX4	390667	broad.mit.edu	37	16	1536565	1536565	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:1536565G>C	uc010uvf.1	-	3	797	c.797C>G	c.(796-798)CCC>CGC	p.P266R		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	271	Pentaxin.					extracellular region	metal ion binding				0						AACGAGGGTGGGGCCCACGCC	0.632			NA											17	12					0	0	0.004007	0	0
C16orf89	146556	broad.mit.edu	37	16	5110370	5110370	+	Silent	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:5110370G>C	uc010bud.2	-	3	628	c.540C>G	c.(538-540)TCC>TCG	p.S180S	ALG1_uc002cyj.2_Intron|C16orf89_uc002cyk.3_Silent_p.S180S	NM_152459	NP_689672	Q6UX73	CP089_HUMAN	hypothetical protein LOC146556 isoform 1	142						extracellular region				ovary(1)|skin(1)	2						GGTACACCAAGGAGGCATCAG	0.617			NA											10	35					0	0	0.006214	0	0
XYLT1	64131	broad.mit.edu	37	16	17294451	17294451	+	Missense_Mutation	SNP	G	G	T	rs139070566		TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:17294451G>T	uc002dfa.2	-	4	1059	c.974C>A	c.(973-975)CCG>CAG	p.P325Q		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	325	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GATTCTGACCGGGTTGGCTGG	0.552			NA											31	81					1.61788e-16	2.00918e-16	0.012213	1	0
GP2	2813	broad.mit.edu	37	16	20331704	20331704	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:20331704C>T	uc002dgv.2	-	6	830	c.747G>A	c.(745-747)GGG>GGA	p.G249G	GP2_uc002dgw.2_Silent_p.G246G|GP2_uc002dgx.2_Silent_p.G102G|GP2_uc002dgy.2_Silent_p.G99G	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	249	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TGACCTCCTCCCCCAAACCCA	0.572			NA											31	23					0	0	0.010818	0	0
APOB48R	55911	broad.mit.edu	37	16	28507282	28507282	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:28507282G>T	uc002dqb.1	+	2	930	c.920G>T	c.(919-921)GGG>GTG	p.G307V	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	307	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						ATCTCAGGCGGGGAGGAGGCT	0.652			NA											7	7					3.09899e-07	3.25759e-07	0.004482	1	0
ABCC11	85320	broad.mit.edu	37	16	48261771	48261771	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:48261771T>A	uc002eff.1	-	3	691	c.341A>T	c.(340-342)GAG>GTG	p.E114V	ABCC11_uc002efg.1_Missense_Mutation_p.E114V|ABCC11_uc002efh.1_Missense_Mutation_p.E114V|ABCC11_uc010vgl.1_Missense_Mutation_p.E114V	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	114	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GATGGTGTTCTCATCTAAGCG	0.537			NA							Cerumen_Type				31	111					0	0	0.013726	0	0
SALL1	6299	broad.mit.edu	37	16	51176048	51176048	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:51176048C>T	uc010vgs.1	-	2	116	c.85G>A	c.(85-87)GAA>AAA	p.E29K	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	29					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGACCCTTTTCTGTGTCTCCT	0.458	GBM(103;1352 1446 1855 4775 8890)		NA											37	95					0	0	0.00623	0	0
CENPT	80152	broad.mit.edu	37	16	67863987	67863987	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:67863987A>G	uc002eun.3	-	12	1416	c.867T>C	c.(865-867)CCT>CCC	p.P289P	CENPT_uc002eum.3_Silent_p.P289P|CENPT_uc010vkc.1_Silent_p.P47P|CENPT_uc010vkd.1_Silent_p.P42P|CENPT_uc010vke.1_3'UTR	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	289					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CTGGTTTCCCAGGGCCTGAGT	0.582			NA											3	41					0	0	0.004672	0	0
HYDIN	54768	broad.mit.edu	37	16	70954947	70954947	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr16:70954947G>T	uc002ezr.2	-	46	7457	c.7329C>A	c.(7327-7329)GAC>GAA	p.D2443E		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2444										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCTTTGAGTTGTCCCCTTCAC	0.498			NA											52	35					1.48005e-37	2.14768e-37	0.01441	1	0
RPA1	6117	broad.mit.edu	37	17	1783839	1783839	+	Silent	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:1783839T>C	uc002fto.2	+	12	1210	c.1095T>C	c.(1093-1095)GCT>GCC	p.A365A		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	365					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTTTACAGGCTGATAAATTTG	0.428			NA						NER					3	68					0	0	0.009096	0	0
PITPNM3	83394	broad.mit.edu	37	17	6380393	6380393	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:6380393G>A	uc002gdd.3	-	9	1192	c.1041C>T	c.(1039-1041)ACC>ACT	p.T347T	PITPNM3_uc010cln.2_Silent_p.T311T|PITPNM3_uc002gdc.3_5'UTR	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	347					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CGCAGTCATAGGTGGAGGAGT	0.587			NA											26	23					0	0	0.00632	0	0
C17orf74	201243	broad.mit.edu	37	17	7329009	7329009	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:7329009T>C	uc002ggw.2	+	1	75	c.2T>C	c.(1-3)ATG>ACG	p.M1T	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	1						integral to membrane					0		Prostate(122;0.157)				CCCCCCTCCATGGAAAACCAG	0.602			NA											56	68					0	0	0.01441	0	0
TOM1L2	146691	broad.mit.edu	37	17	17801988	17801988	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:17801988C>T	uc002grz.3	-	3	295	c.138G>A	c.(136-138)GGG>GGA	p.G46G	TOM1L2_uc002gry.3_Silent_p.G46G|TOM1L2_uc010vwy.1_Silent_p.G46G|TOM1L2_uc010cpr.2_Silent_p.G46G|TOM1L2_uc010vwz.1_Silent_p.G46G|TOM1L2_uc010vxa.1_Silent_p.G46G|TOM1L2_uc010vxb.1_Silent_p.G46G	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	46	VHS.				intracellular protein transport	intracellular					0	all_neural(463;0.228)					CATCCTTTGGCCTGGaaaaaa	0.284	Melanoma(192;2505 2909 14455 25269)		NA											18	63					0	0	0.00499	0	0
MFAP4	4239	broad.mit.edu	37	17	19287986	19287986	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:19287986G>A	uc002gvt.2	-	6	582	c.557C>T	c.(556-558)TCT>TTT	p.S186F	uc010vyt.1_5'Flank|MFAP4_uc002gvr.2_RNA|MFAP4_uc002gvs.2_Missense_Mutation_p.S210F	NM_002404	NP_002395	P55083	MFAP4_HUMAN	microfibrillar-associated protein 4 precursor	186	Fibrinogen C-terminal.				cell adhesion|signal transduction	microfibril	receptor binding				0	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GTCGAAGGTAGAGAACTTCTG	0.617			NA											25	123					0	0	0.005443	0	0
KRT33B	3884	broad.mit.edu	37	17	39521111	39521111	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:39521111A>G	uc002hwl.2	-	6	1062	c.1017T>C	c.(1015-1017)TAT>TAC	p.Y339Y		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	339	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GCAGCACCTGATACTCCTGGT	0.637			NA											54	71					0	0	0.01441	0	0
HOXB1	3211	broad.mit.edu	37	17	46608140	46608140	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:46608140C>A	uc002ink.1	-	1	133	c.127G>T	c.(127-129)GCA>TCA	p.A43S		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	43						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCTCGCTTGCATAGCTGTCA	0.667			NA											40	66					2.95478e-19	3.88633e-19	0.00874	1	0
CUEDC1	404093	broad.mit.edu	37	17	55951069	55951069	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:55951069C>T	uc002ivd.1	-	4	1193	c.474G>A	c.(472-474)GCG>GCA	p.A158A	CUEDC1_uc002ive.1_Silent_p.A158A	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	158										skin(2)	2						CAGAGCCCAGCGCGTCGATAC	0.617			NA											26	39					0	0	0.004656	0	0
BAHCC1	57597	broad.mit.edu	37	17	79428098	79428098	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:79428098G>T	uc002kaf.2	+	24	6409	c.6409G>T	c.(6409-6411)GCC>TCC	p.A2137S	BAHCC1_uc002kae.2_Missense_Mutation_p.A1367S	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2137							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GGCCCGCGAGGCCCTGTTCCC	0.687			NA											7	11					0.00198382	0.00199879	0.001984	1	0
LAMA1	284217	broad.mit.edu	37	18	7038880	7038880	+	Silent	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr18:7038880G>T	uc002knm.2	-	11	1586	c.1492C>A	c.(1492-1494)CGG>AGG	p.R498R	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	498	Laminin EGF-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGCAGCCCCGGGGGTTTTTT	0.532			NA											43	91					7.53189e-24	1.02603e-23	0.007835	1	0
ROCK1	6093	broad.mit.edu	37	18	18549153	18549153	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr18:18549153C>T	uc002kte.2	-	24	3778	c.2837G>A	c.(2836-2838)AGC>AAC	p.S946N		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	946	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					GGTTAGCATGCTGTTTGCTTC	0.343			NA											20	44					0	0	0.010504	0	0
C18orf34	374864	broad.mit.edu	37	18	30926187	30926187	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr18:30926187C>A	uc002kxn.2	-	8	788	c.646G>T	c.(646-648)GCT>TCT	p.A216S	C18orf34_uc010xbr.1_Missense_Mutation_p.A216S|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.A216S|C18orf34_uc002kxp.2_Missense_Mutation_p.A216S	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	216										ovary(1)	1						TTCTGCACAGCCAATGGGAGT	0.328			NA											36	51					9.8876e-21	1.32663e-20	0.004878	1	0
MOCOS	55034	broad.mit.edu	37	18	33800036	33800036	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr18:33800036G>A	uc002kzq.3	+	9	1839	c.1816G>A	c.(1816-1818)GGA>AGA	p.G606R		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	606					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GTGGCCTGTAGGAAACCAAGG	0.527			NA											59	74					0	0	0.01441	0	0
NETO1	81832	broad.mit.edu	37	18	70526237	70526237	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr18:70526237A>C	uc002lkw.2	-	4	577	c.293T>G	c.(292-294)TTT>TGT	p.F98C	NETO1_uc002lkx.1_Missense_Mutation_p.F97C|NETO1_uc002lky.1_Missense_Mutation_p.F98C|NETO1_uc002lkz.2_Missense_Mutation_p.F97C	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	98	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AATATGATCAAATTTGCACTC	0.393			NA											23	80					0	0	0.012319	0	0
LPPR3	79948	broad.mit.edu	37	19	813107	813107	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:813107G>A	uc002lpx.1	-	8	1684	c.1620C>T	c.(1618-1620)ATC>ATT	p.I540I	LPPR3_uc010dru.1_Silent_p.I452I|LPPR3_uc002lpw.1_Silent_p.I568I|LPPR3_uc002lpy.1_Silent_p.I321I|hsa-mir-3187|MI0014231_5'Flank	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	540						integral to membrane	phosphatidate phosphatase activity				0						TGGACATGGCGATGACCTGCA	0.731			NA											5	4					0	0	0.001168	0	0
FSD1	79187	broad.mit.edu	37	19	4312015	4312015	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:4312015G>T	uc002lzy.2	+	7	820	c.667G>T	c.(667-669)GAG>TAG	p.E223*	FSD1_uc002lzz.2_Nonsense_Mutation_p.E223*|FSD1_uc002maa.2_Nonsense_Mutation_p.E36*	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	223	Fibronectin type-III.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GATGGTCATCGAGGGCATCCG	0.637			NA											10	2					9.70103e-10	1.08831e-09	0.008291	1	0
CHAF1A	10036	broad.mit.edu	37	19	4428734	4428734	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:4428734G>A	uc002mal.2	+	8	1551	c.1451G>A	c.(1450-1452)CGG>CAG	p.R484Q		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	484					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGGCGTCGGACCGCTTTC	0.597			NA						Chromatin_Structure					25	56					0	0	0.005443	0	0
ACER1	125981	broad.mit.edu	37	19	6312431	6312431	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:6312431T>C	uc002mel.2	-	2	251	c.173A>G	c.(172-174)TAC>TGC	p.Y58C		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	58	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						AACGTAAATGTAGCGGGAGCG	0.557			NA											81	15					0	0	0.01441	0	0
MUC16	94025	broad.mit.edu	37	19	9002608	9002608	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:9002608C>A	uc002mkp.2	-	51	40412	c.40208G>T	c.(40207-40209)AGC>ATC	p.S13403I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.S220I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTCCAGGGCTTTTGGGGTC	0.572			NA											62	20					1.31171e-36	1.89311e-36	0.01441	1	0
MUC16	94025	broad.mit.edu	37	19	9009651	9009652	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:9009651_9009652CC>AA	uc002mkp.2	-	39	39278_39279	c.39074_39075GG>TT	c.(39073-39075)GGG>GTT	p.G13025V	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATGTCCTCCCCATACTGCAG	0.554			NA											67	21					0	0	0.004672	0	0
KEAP1	9817	broad.mit.edu	37	19	10600417	10600417	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:10600417C>A	uc002moq.1	-	4	1594	c.1438G>T	c.(1438-1440)GGG>TGG	p.G480W	KEAP1_uc002mop.1_Missense_Mutation_p.G198W|KEAP1_uc002mor.1_Missense_Mutation_p.G480W	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	480	Kelch 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGGTTTGTCCCGTCAAAGCCC	0.582			NA											39	8					1.49673e-21	2.01832e-21	0.00623	1	0
ZNF625	90589	broad.mit.edu	37	19	12256898	12256898	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:12256898G>A	uc002mth.2	-	4	485	c.135C>T	c.(133-135)TCC>TCT	p.S45S	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Silent_p.S79S	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	45	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCTATTAAGGGATGCATGAC	0.438			NA											40	10					0	0	0.00623	0	0
CD97	976	broad.mit.edu	37	19	14512314	14512314	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:14512314G>C	uc002myl.2	+	10	1137	c.1014G>C	c.(1012-1014)ATG>ATC	p.M338I	CD97_uc002mym.2_Missense_Mutation_p.M289I|CD97_uc002myn.2_Missense_Mutation_p.M245I	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	338	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						AAGATATCATGAGGATCCTGG	0.597			NA											16	19					0	0	0.004007	0	0
ZNF536	9745	broad.mit.edu	37	19	31025821	31025821	+	Silent	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:31025821G>T	uc002nsu.1	+	3	2376	c.2238G>T	c.(2236-2238)CTG>CTT	p.L746L	ZNF536_uc010edd.1_Silent_p.L746L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	746					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACAGAAGCCTGGGCTCGGCCA	0.567			NA											34	92					4.65686e-17	5.92087e-17	0.003755	1	0
WDR62	284403	broad.mit.edu	37	19	36575577	36575577	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:36575577G>T	uc002odc.2	+	12	1664	c.1573G>T	c.(1573-1575)GAC>TAC	p.D525Y	WDR62_uc002odd.2_Missense_Mutation_p.D525Y	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	525	WD 7.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCACTTCATGGACGAGCTGGT	0.612			NA											21	17					2.70639e-06	2.8008e-06	0.014323	1	0
DPF1	8193	broad.mit.edu	37	19	38704372	38704372	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:38704372G>T	uc002ohl.2	-	9	899	c.872C>A	c.(871-873)ACG>AAG	p.T291K	DPF1_uc002ohm.2_Missense_Mutation_p.T335K|DPF1_uc002ohn.2_Missense_Mutation_p.T253K|DPF1_uc010xtu.1_Missense_Mutation_p.T309K|DPF1_uc010xtv.1_Missense_Mutation_p.T309K	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	291	PHD-type 1.				induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CATGTTCACCGTGAATTGTAA	0.642			NA											29	30					7.38237e-10	8.31684e-10	0.00632	1	0
RYR1	6261	broad.mit.edu	37	19	38951198	38951198	+	Silent	SNP	C	C	T	rs140374285	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:38951198C>T	uc002oit.2	+	20	2674	c.2544C>T	c.(2542-2544)ACC>ACT	p.T848T	RYR1_uc002oiu.2_Silent_p.T848T	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	848	1.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCTCACACACCGACTTCGTGC	0.612			NA											20	46					0	0	0.00278	0	0
GRIK5	2901	broad.mit.edu	37	19	42507532	42507532	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:42507532C>T	uc002osj.1	-	18	2501	c.2466G>A	c.(2464-2466)GCG>GCA	p.A822A	GRIK5_uc002osi.1_Silent_p.A394A	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	822	Helical; (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	ATTCCATGACCGCCACGAAGA	0.597			NA											31	19					0	0	0.010818	0	0
PSG6	5675	broad.mit.edu	37	19	43411893	43411893	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:43411893G>C	uc002ovj.1	-	4	872	c.820C>G	c.(820-822)CTA>GTA	p.L274V	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.L281V|PSG6_uc002ovi.2_Missense_Mutation_p.L275V|PSG6_uc010xwk.1_Missense_Mutation_p.L114V|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Missense_Mutation_p.L64V|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Missense_Mutation_p.L274V	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	274	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TGACCATTTAGCCACCAAATG	0.483			NA											174	141					0	0	0.01441	0	0
CA11	770	broad.mit.edu	37	19	49143455	49143455	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:49143455G>T	uc002pjz.1	-	4	930	c.368C>A	c.(367-369)CCC>CAC	p.P123H	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	123						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		GTAAAGGAGGGGACCTCCAGA	0.617			NA											21	52					1.10513e-12	1.29417e-12	0.014323	1	0
NUCB1	4924	broad.mit.edu	37	19	49404129	49404129	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:49404129G>C	uc002plb.3	+	2	148	c.76G>C	c.(76-78)GCT>CCT	p.A26P	NUCB1_uc002pla.2_Missense_Mutation_p.A26P|NUCB1_uc002plc.2_Missense_Mutation_p.A26P|TULP2_uc002pkz.2_5'Flank	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	26						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		CGCCGTGCTGGCTGTCCCCCT	0.572			NA											26	26					0	0	0.004656	0	0
LILRB2	10288	broad.mit.edu	37	19	54782271	54782271	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:54782271A>G	uc002qfb.2	-	7	1367	c.1101T>C	c.(1099-1101)CGT>CGC	p.R367R	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.R367R|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.R367R|LILRB2_uc010yet.1_Silent_p.R251R|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	367	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTGATCTTAGACGGAGTGGGG	0.567			NA											82	77					0	0	0.01441	0	0
ZNF211	10520	broad.mit.edu	37	19	58153450	58153450	+	Silent	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:58153450G>T	uc002qpq.2	+	3	1776	c.1596G>T	c.(1594-1596)ACG>ACT	p.T532T	ZNF211_uc010yhb.1_Silent_p.T536T|ZNF211_uc002qpp.2_Silent_p.T545T|ZNF211_uc002qpr.2_Silent_p.T596T|ZNF211_uc002qps.2_Silent_p.T597T|ZNF211_uc002qpt.2_Silent_p.T544T|ZNF211_uc010yhc.1_Silent_p.T544T|ZNF211_uc010yhd.1_Silent_p.T471T|ZNF211_uc010yhe.1_Silent_p.T523T	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	532						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAGTTCACACGGGAAAAAGGC	0.463			NA											79	52					8.50452e-49	1.2615e-48	0.01441	1	0
APOB	338	broad.mit.edu	37	2	21228441	21228441	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:21228441C>T	uc002red.2	-	26	11427	c.11299G>A	c.(11299-11301)GAA>AAA	p.E3767K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3767					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATTTGTATTTCTCTGAAGTCA	0.393			NA											38	160					0	0	0.004878	0	0
LTBP1	4052	broad.mit.edu	37	2	33623498	33623498	+	Silent	SNP	C	C	A	rs113896201	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:33623498C>A	uc002ros.2	+	34	5055	c.5055C>A	c.(5053-5055)ACC>ACA	p.T1685T	LTBP1_uc002rot.2_Silent_p.T1359T|LTBP1_uc002rou.2_Silent_p.T1358T|LTBP1_uc002rov.2_Silent_p.T1305T|LTBP1_uc010ymz.1_Silent_p.T1316T|LTBP1_uc010yna.1_Silent_p.T1263T|LTBP1_uc010ynb.1_Silent_p.T582T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1684	EGF-like 18; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GCATTAACACCGATGGTTCCT	0.448			NA											30	50					1.08312e-15	1.31451e-15	0.009535	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125261950	125261950	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:125261950C>T	uc002tno.2	+	8	1505	c.1141C>T	c.(1141-1143)CCC>TCC	p.P381S	CNTNAP5_uc010flu.2_Missense_Mutation_p.P382S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	381	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTTGCTGCTGCCCGGCACCCC	0.517			NA											16	90					0	0	0.004007	0	0
LRP1B	53353	broad.mit.edu	37	2	141093378	141093378	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:141093378A>G	uc002tvj.1	-	78	12894	c.11922T>C	c.(11920-11922)ATT>ATC	p.I3974I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3974	Extracellular (Potential).|LDL-receptor class B 33.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTCAACTGCAATGTCCCTGG	0.418	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			21	130					0	0	0.012319	0	0
NEB	4703	broad.mit.edu	37	2	152512792	152512792	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:152512792C>A	uc010fnx.2	-	49	6561	c.6370G>T	c.(6370-6372)GCT>TCT	p.A2124S		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2124	Nebulin 56.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCTTTGCAGCCGTGACACTG	0.483			NA											129	195					6.92432e-61	1.03285e-60	0.01441	1	0
XIRP2	129446	broad.mit.edu	37	2	168103772	168103773	+	Nonsense_Mutation	DNP	CG	CG	AA			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:168103772_168103773CG>AA	uc002udx.2	+	8	5888_5889	c.5870_5871CG>AA	c.(5869-5871)TCG>TAA	p.S1957*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.S1782*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.S1735*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1782					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCAGGATCCTCGGGAGAGCAGA	0.431			NA											30	57					0	0	0.004672	0	0
LRP2	4036	broad.mit.edu	37	2	170134283	170134283	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:170134283C>G	uc002ues.2	-	13	1957	c.1744G>C	c.(1744-1746)GAA>CAA	p.E582Q	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	582	LDL-receptor class B 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTACAGTTTCAATGTAATCA	0.388			NA											17	152					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179465890	179465890	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:179465890C>G	uc010zfg.1	-	237	48261	c.48037G>C	c.(48037-48039)GAT>CAT	p.D16013H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D9708H|TTN_uc010zfi.1_Missense_Mutation_p.D9641H|TTN_uc010zfj.1_Missense_Mutation_p.D9516H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16940							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGGAGGATCAGGAGGATCT	0.348			NA											23	51					0	0	0.00278	0	0
MYO1B	4430	broad.mit.edu	37	2	192257825	192257825	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:192257825G>T	uc010fsg.2	+	20	2358	c.2103G>T	c.(2101-2103)AAG>AAT	p.K701N	MYO1B_uc002usq.2_Missense_Mutation_p.K701N|MYO1B_uc002usr.2_Missense_Mutation_p.K701N|MYO1B_uc002usu.2_5'UTR	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	701						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ACCTGAGGAAGCAACGCCTGG	0.408			NA											16	79					1.62849e-17	2.09042e-17	0.004007	1	0
DNAH7	56171	broad.mit.edu	37	2	196822039	196822039	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:196822039T>A	uc002utj.3	-	19	3125	c.3024A>T	c.(3022-3024)AGA>AGT	p.R1008S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1008	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTGTAAATCGTCTGCCTTCCT	0.428			NA											62	43					0	0	0.01441	0	0
UNC80	285175	broad.mit.edu	37	2	210642218	210642218	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:210642218C>A	uc010zjc.1	+	4	615	c.535C>A	c.(535-537)CAG>AAG	p.Q179K	UNC80_uc002vdj.1_Missense_Mutation_p.Q179K	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	179						integral to membrane					0						AAAGATCTTCCAGAACTCCAT	0.502			NA											68	112					4.90955e-16	6.04079e-16	0.01441	1	0
ABCA12	26154	broad.mit.edu	37	2	215845334	215845334	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:215845334T>A	uc002vew.2	-	31	4833	c.4613A>T	c.(4612-4614)GAC>GTC	p.D1538V	ABCA12_uc002vev.2_Missense_Mutation_p.D1220V|ABCA12_uc010zjn.1_Missense_Mutation_p.D465V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1538	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTCAGCCTCGTCCAAGTGGTG	0.512	Ovarian(66;664 1488 5121 34295)		NA											60	42					0	0	0.01441	0	0
BCS1L	617	broad.mit.edu	37	2	219528080	219528080	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr2:219528080A>G	uc002vio.2	+	8	1649	c.1231A>G	c.(1231-1233)ATT>GTT	p.I411V	BCS1L_uc002vip.2_Missense_Mutation_p.I411V|BCS1L_uc002viq.2_Missense_Mutation_p.I411V|BCS1L_uc010fvu.2_Missense_Mutation_p.I411V|BCS1L_uc010fvv.2_Missense_Mutation_p.I411V|BCS1L_uc002vir.2_Missense_Mutation_p.I411V|BCS1L_uc002vis.2_Missense_Mutation_p.I411V	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	411	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTAGGGGCAATTCACAATGC	0.498			NA											46	47					0	0	0.013114	0	0
SIRPG	55423	broad.mit.edu	37	20	1638338	1638338	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:1638338G>T	uc002wfm.1	-	1	88	c.23C>A	c.(22-24)CCC>CAC	p.P8H	SIRPG_uc002wfn.1_Missense_Mutation_p.P8H|SIRPG_uc002wfo.1_Missense_Mutation_p.P8H	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	8					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGGAGGATGGGGCCAGGAGGC	0.552			NA											35	42					1.67305e-13	1.99421e-13	0.00623	1	0
KIF16B	55614	broad.mit.edu	37	20	16359627	16359627	+	Missense_Mutation	SNP	C	C	A	rs61754557	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:16359627C>A	uc002wpg.1	-	19	3178	c.3020G>T	c.(3019-3021)CGG>CTG	p.R1007L	KIF16B_uc002wpe.1_Missense_Mutation_p.R389L|KIF16B_uc002wpf.1_Missense_Mutation_p.R389L|KIF16B_uc010gch.1_Missense_Mutation_p.R1007L|KIF16B_uc010gci.1_Missense_Mutation_p.R1007L|KIF16B_uc010gcj.1_Missense_Mutation_p.R1018L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1007	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GGCCAGGGCCCGCTCCAGCGC	0.547			NA											66	83					5.08636e-23	6.8937e-23	0.01441	1	0
CST9L	128821	broad.mit.edu	37	20	23545588	23545588	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:23545588G>T	uc002wtk.3	-	3	740	c.441C>A	c.(439-441)CAC>CAA	p.H147Q		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	147						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					GTTTCACTCAGTGGAATCCCT	0.537			NA											47	51					6.27289e-28	8.72324e-28	0.01441	1	0
ZNF217	7764	broad.mit.edu	37	20	52198393	52198393	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:52198393C>A	uc002xwq.3	-	1	1244	c.973G>T	c.(973-975)GAC>TAC	p.D325Y	ZNF217_uc010gij.1_Missense_Mutation_p.D317Y	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	325					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CTCGAATCGTCGTTGTCGGTG	0.532			NA											70	91					9.12251e-31	1.28874e-30	0.01441	1	0
GNAS	2778	broad.mit.edu	37	20	57415891	57415891	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:57415891C>T	uc002xzt.2	+	1	1097	c.730C>T	c.(730-732)CGT>TGT	p.R244C	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCCCATCCGGCGTCACTAATG	0.612	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			11	32					0	0	0.008291	0	0
RTEL1	51750	broad.mit.edu	37	20	62317196	62317196	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr20:62317196C>T	uc002yfu.1	+	16	1662	c.1319C>T	c.(1318-1320)GCC>GTC	p.A440V	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.A440V|RTEL1_uc011abd.1_Missense_Mutation_p.A464V|RTEL1_uc011abe.1_Missense_Mutation_p.A217V|RTEL1_uc002yfw.2_RNA	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	440					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CGGTCTGATGCCTGGAGCACC	0.682			NA											6	24					0	0	0.00308	0	0
MRPL39	54148	broad.mit.edu	37	21	26978821	26978821	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr21:26978821C>A	uc002ylo.2	-	2	234	c.220G>T	c.(220-222)GAC>TAC	p.D74Y	MRPL39_uc002yln.2_Missense_Mutation_p.D74Y	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	74						mitochondrial ribosome	nucleotide binding				0						GTACCGGGGTCAGTTTTCCCA	0.408			NA											31	12					3.1745e-13	3.7504e-13	0.008361	1	0
TRPM2	7226	broad.mit.edu	37	21	45795821	45795821	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr21:45795821G>T	uc002zet.1	+	7	1090	c.877G>T	c.(877-879)GGC>TGC	p.G293C	TRPM2_uc002zeu.1_Missense_Mutation_p.G293C|TRPM2_uc002zew.1_Missense_Mutation_p.G293C|TRPM2_uc010gpt.1_Missense_Mutation_p.G293C|TRPM2_uc002zex.1_Missense_Mutation_p.G79C	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	293	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CGGGACCCACGGCCAGTACGG	0.582			NA											30	49					4.3181e-19	5.65163e-19	0.013726	1	0
MYO18B	84700	broad.mit.edu	37	22	26422575	26422576	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr22:26422575_26422576CC>AT	uc003abz.1	+	43	6885_6886	c.6635_6636CC>AT	c.(6634-6636)GCC>GAT	p.A2212D	MYO18B_uc003aca.1_Missense_Mutation_p.A2093D|MYO18B_uc010guy.1_Missense_Mutation_p.A2094D|MYO18B_uc010guz.1_Missense_Mutation_p.A2092D|MYO18B_uc011aka.1_Missense_Mutation_p.A1366D|MYO18B_uc011akb.1_Missense_Mutation_p.A1725D|MYO18B_uc010gva.1_Missense_Mutation_p.A195D|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2212						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAGTGCTTGCCGTCCAGAGAA	0.545			NA											25	10					0	0	0.004672	0	0
CRYBB1	1414	broad.mit.edu	37	22	26995528	26995528	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr22:26995528G>T	uc003acy.1	-	6	755	c.685C>A	c.(685-687)CTG>ATG	p.L229M		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	229	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			ovary(1)	1						AGGCGACGCAGGGACTGCATC	0.617			NA											39	6					2.75727e-19	3.66265e-19	0.004878	1	0
TBC1D5	9779	broad.mit.edu	37	3	17446369	17446369	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:17446369C>T	uc003cbf.2	-	6	2026	c.361G>A	c.(361-363)GAA>AAA	p.E121K	TBC1D5_uc010hev.2_Missense_Mutation_p.E121K|TBC1D5_uc003cbe.2_Missense_Mutation_p.E121K|TBC1D5_uc010hew.1_Missense_Mutation_p.E73K	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	121	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CTTACTATTTCTTTAATGTTG	0.303			NA											11	14					0	0	0.008291	0	0
SATB1	6304	broad.mit.edu	37	3	18436096	18436096	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:18436096C>T	uc003cbh.2	-	7	2799	c.1064G>A	c.(1063-1065)AGA>AAA	p.R355K	SATB1_uc003cbi.2_Missense_Mutation_p.R355K|SATB1_uc003cbj.2_Missense_Mutation_p.R355K	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	355					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						ATTCATAGATCTACTGACAGG	0.483			NA											66	64					0	0	0.01441	0	0
UBE2E2	7325	broad.mit.edu	37	3	23631271	23631271	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:23631271A>C	uc003ccg.2	+	6	735	c.555A>C	c.(553-555)AGA>AGC	p.R185S	UBE2E2_uc010hfc.2_RNA	NM_152653	NP_689866	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	185					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity				0						TGACCAACAGAGCAGAGCATG	0.592	GBM(85;1941 2083 9456)		NA											11	62					0	0	0.013537	0	0
OSBPL10	114884	broad.mit.edu	37	3	31710172	31710172	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:31710172C>A	uc003cev.2	-	11	2439	c.2058G>T	c.(2056-2058)AAG>AAT	p.K686N	OSBPL10_uc003ceu.1_Missense_Mutation_p.K443N|OSBPL10_uc011axf.1_Missense_Mutation_p.K622N	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	686					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		GAGGTCTGATCTTCTTGGGAT	0.512			NA											22	58					1.96895e-08	2.11979e-08	0.00278	1	0
NKTR	4820	broad.mit.edu	37	3	42680794	42680794	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:42680794A>T	uc003clo.2	+	13	3745	c.3598A>T	c.(3598-3600)AGC>TGC	p.S1200C	NKTR_uc003clm.1_Missense_Mutation_p.S947C|NKTR_uc003clp.2_Missense_Mutation_p.S947C|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.S1090C|NKTR_uc003clr.1_Missense_Mutation_p.S947C|NKTR_uc003cls.2_Missense_Mutation_p.S900C	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1200					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CAGCTCTGCTAGCTTGGCTAG	0.512			NA											16	46					0	0	0.00499	0	0
WDR6	11180	broad.mit.edu	37	3	49049802	49049802	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:49049802G>A	uc003cvj.2	+	2	1063	c.925G>A	c.(925-927)GTC>ATC	p.V309I	WDR6_uc011bbx.1_Missense_Mutation_p.V180I|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.V253I|WDR6_uc011bbz.1_Missense_Mutation_p.V228I	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	279	WD 4.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		AGAGGATTGTGTCTGCTTGGT	0.587			NA											18	44					0	0	0.00499	0	0
OR5H1	26341	broad.mit.edu	37	3	97851965	97851965	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:97851965A>T	uc011bgt.1	+	1	424	c.424A>T	c.(424-426)ATC>TTC	p.I142F		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	142	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TGGACTGTGCATCCGGCTATT	0.388			NA											44	80					0	0	0.01441	0	0
OR5H14	403273	broad.mit.edu	37	3	97868653	97868653	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:97868653A>T	uc003dsg.1	+	1	424	c.424A>T	c.(424-426)ATC>TTC	p.I142F		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	142	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGGACTGTGCATCCGGCTATT	0.388			NA											7	167					0	0	0.008291	0	0
PDIA5	10954	broad.mit.edu	37	3	122865026	122865026	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:122865026G>A	uc003egc.1	+	13	1118	c.1062G>A	c.(1060-1062)ACG>ACA	p.T354T	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	354	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		AGTTTCCTACGTTGAAGTATT	0.478			NA											46	117					0	0	0.010771	0	0
PTPLB	201562	broad.mit.edu	37	3	123247306	123247306	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:123247306G>C	uc003egj.2	-	4	358	c.308C>G	c.(307-309)TCT>TGT	p.S103C		NM_198402	NP_940684	Q6Y1H2	HACD2_HUMAN	protein tyrosine phosphatase-like (proline	103	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein binding			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.1)		CAGGACAACAGAAGATGGAAC	0.308			NA											14	40					0	0	0.004007	0	0
KALRN	8997	broad.mit.edu	37	3	123813710	123813710	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:123813710G>C	uc003ehg.2	+	1	153	c.26G>C	c.(25-27)TGG>TCG	p.W9S	KALRN_uc003ehd.2_Intron|KALRN_uc003ehe.2_RNA|KALRN_uc010hru.1_RNA|KALRN_uc010hrv.1_Missense_Mutation_p.W9S|KALRN_uc010hrw.1_RNA|KALRN_uc003ehf.1_Missense_Mutation_p.W9S|KALRN_uc011bjy.1_Missense_Mutation_p.W9S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	9					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TGGGACCAGTGGTATCTCTGG	0.498			NA											24	12					0	0	0.00632	0	0
RUVBL1	8607	broad.mit.edu	37	3	127842496	127842496	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:127842496C>T	uc003ekh.2	-	1	176	c.72G>A	c.(70-72)CTG>CTA	p.L24L	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Silent_p.L24L	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	24					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CGTCCAGCCCCAGCCCTTTCA	0.637			NA											14	29					0	0	0.003163	0	0
XRN1	54464	broad.mit.edu	37	3	142037437	142037437	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:142037437T>A	uc003eus.2	-	39	4682	c.4615A>T	c.(4615-4617)ACT>TCT	p.T1539S	XRN1_uc010huu.2_Missense_Mutation_p.T1006S|XRN1_uc003eut.2_Missense_Mutation_p.T1539S|XRN1_uc003euu.2_Missense_Mutation_p.T1540S	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1539					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATCTTACCAGTAGGTGGGGGA	0.368			NA											3	5					0	0	0.004672	0	0
SIAH2	6478	broad.mit.edu	37	3	150459956	150459956	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:150459956T>C	uc003eyi.2	-	2	1574	c.947A>G	c.(946-948)AAT>AGT	p.N316S		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	316	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AATAGTAACATTGATTCCAAG	0.388			NA											18	54					0	0	0.008871	0	0
KLHL24	54800	broad.mit.edu	37	3	183368462	183368463	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:183368462_183368463GG>TT	uc003flv.2	+	3	613_614	c.318_319GG>TT	c.(316-321)TTGGTT>TTTTTT	p.106_107LV>FF	KLHL24_uc003flw.2_Missense_Mutation_p.106_107LV>FF|KLHL24_uc003flx.2_Missense_Mutation_p.106_107LV>FF	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	106_107	BTB.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GAGAAATGTTGGTTGAGATCAA	0.396			NA											92	67					0	0	0.004672	0	0
FGF12	2257	broad.mit.edu	37	3	191888341	191888341	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:191888341C>T	uc003fsx.2	-	4	1345	c.519G>A	c.(517-519)TGG>TGA	p.W173*	FGF12_uc003fsy.2_Nonsense_Mutation_p.W111*	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	173					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GTCCCAGAAACCAAGCTCGGC	0.408			NA											35	152					0	0	0.003755	0	0
HTT	3064	broad.mit.edu	37	4	3176766	3176766	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:3176766C>T	uc011bvq.1	+	34	4490	c.4345C>T	c.(4345-4347)CAG>TAG	p.Q1449*		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1447					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTTACAGAAGCAGGTTTTAGA	0.368			NA											28	36					0	0	0.005443	0	0
EVC2	132884	broad.mit.edu	37	4	5624431	5624431	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:5624431C>T	uc003gij.2	-	14	2388	c.2334G>A	c.(2332-2334)GAG>GAA	p.E778E	EVC2_uc011bwb.1_Silent_p.E218E|EVC2_uc003gik.2_Silent_p.E698E	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	778	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TGCCGTGCTCCTCCAGGATCT	0.657			NA											15	57					0	0	0.003163	0	0
WDR1	9948	broad.mit.edu	37	4	10083005	10083005	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:10083005G>A	uc003gmf.2	-	11	1543	c.1260C>T	c.(1258-1260)TAC>TAT	p.Y420Y	WDR1_uc003gmg.2_Silent_p.Y280Y|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	420					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CGACCACGGCGTATCCCCCGG	0.557			NA											8	41					0	0	0.006214	0	0
GPR125	166647	broad.mit.edu	37	4	22390127	22390127	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:22390127G>A	uc003gqm.1	-	19	3432	c.3167C>T	c.(3166-3168)GCG>GTG	p.A1056V	GPR125_uc010ieo.1_Missense_Mutation_p.A912V|GPR125_uc003gql.1_Missense_Mutation_p.A183V	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	1056	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				CATGATCCACGCAAGTCTAAC	0.498			NA											26	55					0	0	0.004656	0	0
GABRA4	2557	broad.mit.edu	37	4	46979530	46979530	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:46979530C>A	uc003gxg.2	-	4	530	c.391G>T	c.(391-393)GAT>TAT	p.D131Y		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	131	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGAAAGTATCAGGGGTCCAC	0.343	Ovarian(6;283 369 8234 12290 33402)		NA											31	50					3.57733e-08	3.83593e-08	0.009535	1	0
SRD5A3	79644	broad.mit.edu	37	4	56230251	56230251	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:56230251G>A	uc003hau.2	+	3	470	c.375G>A	c.(373-375)CTG>CTA	p.L125L	uc003hav.1_RNA	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	125	Helical; (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GAGGGGAGCTGGCACTGTCTG	0.428			NA											32	95					0	0	0.004289	0	0
STAP1	26228	broad.mit.edu	37	4	68472042	68472042	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:68472042T>A	uc003hde.3	+	9	937	c.855T>A	c.(853-855)AGT>AGA	p.S285R	STAP1_uc003hdf.2_Missense_Mutation_p.S285R	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	285					cellular membrane fusion|intracellular protein transport	cytoplasm					0						AAGGGAGAAGTGAAAAGTTGA	0.323			NA											13	32					0	0	0.00499	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68956241	68956241	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:68956241C>A	uc003hdt.1	-	3	331	c.282G>T	c.(280-282)ATG>ATT	p.M94I		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	94	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TTGAGCTTACCATTCTTTCAA	0.259			NA											27	17					2.12542e-12	2.4781e-12	0.00632	1	0
SLC6A18	348932	broad.mit.edu	37	5	1235661	1235661	+	Missense_Mutation	SNP	A	A	G	rs139414850	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:1235661A>G	uc003jby.1	+	4	628	c.505A>G	c.(505-507)ATC>GTC	p.I169V		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	169	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GACACTGAACATCACAGCCGA	0.597			NA											38	57					0	0	0.007835	0	0
CDH12	1010	broad.mit.edu	37	5	21854823	21854823	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:21854823G>A	uc010iuc.2	-	4	1061	c.603C>T	c.(601-603)AGC>AGT	p.S201S	CDH12_uc011cno.1_Intron|CDH12_uc003jgk.2_Silent_p.S201S	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	201	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CCTGAAGAATGCTGTAAACGA	0.398			NA								HNSCC(59;0.17)			33	36					0	0	0.003755	0	0
HCN1	348980	broad.mit.edu	37	5	45645442	45645442	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:45645442C>A	uc003jok.2	-	2	719	c.694G>T	c.(694-696)GTG>TTG	p.V232L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	232	Helical; Name=Segment S3; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATATAATCCACTGGGATGGAT	0.378			NA											26	36					3.01185e-09	3.32299e-09	0.003954	1	0
RGNEF	64283	broad.mit.edu	37	5	73181890	73181890	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:73181890G>T	uc011csq.1	+	24	3282	c.3271G>T	c.(3271-3273)GGC>TGC	p.G1091C	RGNEF_uc003kcx.2_Missense_Mutation_p.G1091C|RGNEF_uc010izf.2_Missense_Mutation_p.G1091C|RGNEF_uc011csr.1_Missense_Mutation_p.G778C|RGNEF_uc003kcz.3_Missense_Mutation_p.G55C|RGNEF_uc003kda.3_Missense_Mutation_p.G55C	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1091	PH.				cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GTTATATGATGGCCTTGTTTA	0.393			NA											30	24					2.61193e-14	3.12729e-14	0.009535	1	0
HOMER1	9456	broad.mit.edu	37	5	78697723	78697723	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:78697723C>T	uc003kfy.2	-	6	1786	c.683G>A	c.(682-684)CGG>CAG	p.R228Q	HOMER1_uc010jab.2_Intron|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Missense_Mutation_p.R54Q	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	228	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TGAAATTACCCGCTTGTGCAG	0.458			NA											35	127					0	0	0.00623	0	0
CMYA5	202333	broad.mit.edu	37	5	79034466	79034466	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:79034466A>C	uc003kgc.2	+	2	9950	c.9878A>C	c.(9877-9879)AAG>ACG	p.K3293T		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3293						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGCAGGGAGAAGAGTCTGGAA	0.458			NA											43	40					0	0	0.010771	0	0
VCAN	1462	broad.mit.edu	37	5	82815621	82815621	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:82815621T>A	uc003kii.3	+	7	1852	c.1496T>A	c.(1495-1497)GTA>GAA	p.V499E	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.V499E|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	499	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGTCCTTTGGTAACATCTATG	0.398			NA											71	55					0	0	0.01441	0	0
POU5F2	134187	broad.mit.edu	37	5	93076921	93076921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:93076921C>A	uc003kkl.1	-	1	389	c.349G>T	c.(349-351)GAG>TAG	p.E117*	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	117						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		GAGATGTCCTCTGGCGGCGGC	0.627			NA											21	40					6.21321e-17	7.82513e-17	0.00278	1	0
FTMT	94033	broad.mit.edu	37	5	121188081	121188081	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:121188081C>A	uc003kss.2	+	1	432	c.423C>A	c.(421-423)CGC>CGA	p.R141R		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	141	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GCCGGATCCGCCTGCAGGACA	0.577			NA											20	54					8.34094e-07	8.69934e-07	0.008871	1	0
PCDHA1	56147	broad.mit.edu	37	5	140167837	140167837	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:140167837C>T	uc003lhb.2	+	1	1962	c.1962C>T	c.(1960-1962)CAC>CAT	p.H654H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.H654H	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	654	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGGATCACGGTGAGCCGG	0.662			NA											18	46					0	0	0.00499	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209241	140209241	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:140209241C>A	uc003lho.2	+	1	1592	c.1565C>A	c.(1564-1566)CCG>CAG	p.P522Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.P522Q|PCDHA6_uc011dab.1_Missense_Mutation_p.P522Q	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	522	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCTGCAGCCGCTGGACCAC	0.682			NA											33	118					3.62531e-18	4.67612e-18	0.004289	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553928	140553928	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:140553928C>A	uc003lit.2	+	1	1686	c.1512C>A	c.(1510-1512)GTC>GTA	p.V504V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	504	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCCTGGTCTCCATCAACG	0.677			NA											46	116					5.78141e-17	7.31582e-17	0.013114	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140711266	140711266	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:140711266G>T	uc003lji.1	+	1	1015	c.1015G>T	c.(1015-1017)GAT>TAT	p.D339Y	PCDHGA1_uc011dan.1_Missense_Mutation_p.D339Y	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	339	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGTTTTGGATGTAAATGA	0.433			NA											20	52					4.35082e-09	4.78053e-09	0.010504	1	0
PIP5K1P1	206426	broad.mit.edu	37	6	7988108	7988108	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:7988108C>A	uc003mxx.3	+	1	1774	c.1339C>A	c.(1339-1341)CCT>ACT	p.P447T	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						GAAGCCTTCTCCTTCCAAAAA	0.507			NA											23	71					7.41877e-09	8.08569e-09	0.012319	1	0
SYNGAP1	8831	broad.mit.edu	37	6	33405711	33405711	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:33405711C>T	uc011dri.1	+	8	1224	c.1029C>T	c.(1027-1029)GTC>GTT	p.V343V	SYNGAP1_uc003oeo.1_Silent_p.V328V|SYNGAP1_uc010juy.2_Silent_p.V328V|SYNGAP1_uc010juz.2_Silent_p.V55V	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	343	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CAGGCTATGTCGGCCTGGTGA	0.607			NA											37	62					0	0	0.007835	0	0
COL21A1	81578	broad.mit.edu	37	6	55926451	55926451	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:55926451C>A	uc003pcs.2	-	25	2433	c.2201G>T	c.(2200-2202)GGA>GTA	p.G734V	COL21A1_uc010jzz.2_Missense_Mutation_p.G119V|COL21A1_uc011dxg.1_Missense_Mutation_p.G107V|COL21A1_uc011dxh.1_Missense_Mutation_p.G119V|COL21A1_uc003pcr.2_Nonsense_Mutation_p.E92*	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	734	Collagen-like 5.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACATACCTCTCCTTTTGCACC	0.338			NA											3	15					0.000602214	0.000609058	0.000602	1	0
DST	667	broad.mit.edu	37	6	56391233	56391233	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:56391233G>A	uc003pdf.2	-	63	11726	c.11698C>T	c.(11698-11700)CGC>TGC	p.R3900C	DST_uc003pcz.3_Missense_Mutation_p.R3722C|DST_uc011dxj.1_Missense_Mutation_p.R3751C|DST_uc011dxk.1_Missense_Mutation_p.R3762C|DST_uc003pcy.3_Missense_Mutation_p.R3396C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5808					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATCGGTAGCGCTCATTGTCC	0.488			NA											23	132					0	0	0.014323	0	0
EYS	346007	broad.mit.edu	37	6	66063424	66063424	+	Silent	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:66063424T>A	uc011dxu.1	-	9	1924	c.1386A>T	c.(1384-1386)GGA>GGT	p.G462G	EYS_uc003peq.2_Silent_p.G462G|EYS_uc003per.1_Silent_p.G462G	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	462					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GGAAGGTGACTCCACAGTAGC	0.363			NA											17	68					0	0	0.00499	0	0
PRDM1	639	broad.mit.edu	37	6	106547325	106547325	+	Missense_Mutation	SNP	A	A	C	rs151324489	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:106547325A>C	uc003prd.2	+	4	796	c.562A>C	c.(562-564)AAG>CAG	p.K188Q	PRDM1_uc003pre.2_Missense_Mutation_p.K54Q	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	188	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CTACACCATTAAGCCCATCCC	0.502			NA	D|N|Mis|F|S		DLBCL								22	38					0	0	0.012319	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584148	138584148	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:138584148G>A	uc003qhu.2	+	12	1528	c.1528G>A	c.(1528-1530)GAC>AAC	p.D510N		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	510					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TGTCACCACAGACACAGGCCA	0.592			NA											5	3					0	0	0.000602	0	0
STXBP5	134957	broad.mit.edu	37	6	147680300	147680300	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:147680300G>A	uc003qlz.2	+	23	2547	c.2386G>A	c.(2386-2388)GCT>ACT	p.A796T	STXBP5_uc010khz.1_Missense_Mutation_p.A760T|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.A451T	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	796	WD 11.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		AGCGATCTCCGCTCTTCATTT	0.443			NA											14	22					0	0	0.003163	0	0
RBM16	22828	broad.mit.edu	37	6	155131230	155131230	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:155131230A>G	uc003qqa.2	+	13	1540	c.1308A>G	c.(1306-1308)AGA>AGG	p.R436R	RBM16_uc011efj.1_Silent_p.R502R|RBM16_uc011efk.1_Silent_p.R481R|RBM16_uc003qpz.2_Silent_p.R436R|RBM16_uc010kji.2_Silent_p.R457R	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	436	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CCCGCTCAAGAGAAAGAAAGA	0.423			NA											63	23					0	0	0.01441	0	0
RBM16	22828	broad.mit.edu	37	6	155153764	155153764	+	Silent	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:155153764G>T	uc003qqa.2	+	21	3283	c.3051G>T	c.(3049-3051)CGG>CGT	p.R1017R	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Silent_p.R1083R|RBM16_uc011efk.1_Silent_p.R1062R|RBM16_uc003qpz.2_Silent_p.R1017R|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	1017	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		GAGATTACCGGTTTCCTCCTA	0.458			NA											45	7					9.84934e-19	1.27659e-18	0.010771	1	0
C6orf118	168090	broad.mit.edu	37	6	165713903	165713903	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:165713903C>A	uc003qum.3	-	3	862	c.826G>T	c.(826-828)GAT>TAT	p.D276Y	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	276											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TTACAAATATCTTCAAAGACT	0.403			NA											52	20					7.05377e-20	9.41678e-20	0.01441	1	0
CCR6	1235	broad.mit.edu	37	6	167550348	167550348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr6:167550348G>A	uc003qvl.2	+	13	3106	c.630G>A	c.(628-630)TGG>TGA	p.W210*	CCR6_uc010kkm.2_Nonsense_Mutation_p.W210*|CCR6_uc003qvn.3_Nonsense_Mutation_p.W210*|CCR6_uc003qvm.3_Nonsense_Mutation_p.W210*	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	210	Extracellular (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CCATCAGGTGGAAGCTGCTGA	0.448			NA											25	47					0	0	0.005443	0	0
SDK1	221935	broad.mit.edu	37	7	4247749	4247749	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:4247749G>C	uc003smx.2	+	37	5372	c.5233G>C	c.(5233-5235)GAC>CAC	p.D1745H	SDK1_uc010kso.2_Missense_Mutation_p.D1001H|SDK1_uc003smy.2_Missense_Mutation_p.D232H	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1745	Fibronectin type-III 11.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTGGGAGGCAGACAGCCAGAA	0.557			NA											9	64					0	0	0.010729	0	0
TBX20	57057	broad.mit.edu	37	7	35280533	35280533	+	Silent	SNP	T	T	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:35280533T>A	uc011kas.1	-	5	782	c.771A>T	c.(769-771)CCA>CCT	p.P257P		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	257	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						AAACTGTTTCTGGAAAGATGA	0.413			NA											25	22					0	0	0.004656	0	0
SEPT14	346288	broad.mit.edu	37	7	55910638	55910638	+	Silent	SNP	A	A	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:55910638A>G	uc003tqz.2	-	5	672	c.555T>C	c.(553-555)AGT>AGC	p.S185S		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	185					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AACATACCTTACTGTCAAGGT	0.254			NA											2	2					0	0	0.004672	0	0
SPDYE5	442590	broad.mit.edu	37	7	75126022	75126022	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:75126022G>A	uc011kfy.1	+	2	421	c.285G>A	c.(283-285)CCG>CCA	p.P95P		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	95											0						CCAGCCCCCCGCATAGGTCCT	0.567			NA											10	22					0	0	0.008291	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964545	88964545	+	Missense_Mutation	SNP	T	T	C	rs143293437		TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:88964545T>C	uc011khi.1	+	4	2787	c.2249T>C	c.(2248-2250)GTT>GCT	p.V750A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	750						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CACCACTCAGTTGAAAGGCAC	0.408			NA								HNSCC(36;0.09)			15	62					0	0	0.00245	0	0
AKAP9	10142	broad.mit.edu	37	7	91709239	91709239	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:91709239G>T	uc003ulg.2	+	31	8017	c.7792G>T	c.(7792-7794)GGG>TGG	p.G2598W	AKAP9_uc003ulf.2_Missense_Mutation_p.G2590W|AKAP9_uc003uli.2_Missense_Mutation_p.G2221W|AKAP9_uc003ulj.2_Missense_Mutation_p.G368W	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2610	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGATGAGTTGGGGTCAGATAT	0.303			NA	T	BRAF	papillary thyroid								44	44					3.76604e-16	4.65524e-16	0.010771	1	0
LRCH4	4034	broad.mit.edu	37	7	100174326	100174326	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:100174326T>C	uc003uvj.2	-	14	1596	c.1543A>G	c.(1543-1545)AGT>GGT	p.S515G	uc003uvh.2_5'Flank|LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_Missense_Mutation_p.S42G	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	515					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTGAGCCACTCTGAGAGGAG	0.632			NA											4	4					0	0	0.000602	0	0
LRRN3	54674	broad.mit.edu	37	7	110762783	110762783	+	Translation_Start_Site	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:110762783G>A	uc003vft.3	+	4	1001	c.-45G>A	c.(-47--43)CTGTG>CTATG		IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Translation_Start_Site|LRRN3_uc003vfs.3_Translation_Start_Site	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor							integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AGCACTGACTGTGGAATCCTT	0.408			NA											13	49					0	0	0.013537	0	0
PLXNA4	91584	broad.mit.edu	37	7	131844299	131844299	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:131844299C>A	uc003vra.3	-	25	4822	c.4593G>T	c.(4591-4593)AAG>AAT	p.K1531N		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1531	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CATCCAGAATCTTCTCCTTGA	0.552			NA											65	166					9.40535e-28	1.30115e-27	0.01441	1	0
NOS3	4846	broad.mit.edu	37	7	150695764	150695764	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr7:150695764C>G	uc003wif.2	+	7	1108	c.812C>G	c.(811-813)ACC>AGC	p.T271S	NOS3_uc011kuy.1_Missense_Mutation_p.T65S|NOS3_uc011kuz.1_Missense_Mutation_p.T271S|NOS3_uc011kva.1_Missense_Mutation_p.T271S|NOS3_uc011kvb.1_Missense_Mutation_p.T271S	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	271	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GTGGAGATCACCGAGGTGGGC	0.652			NA											3	5					0	0	0.004672	0	0
UBXN2B	137886	broad.mit.edu	37	8	59329441	59329441	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:59329441G>A	uc003xtl.2	+	2	239	c.117G>A	c.(115-117)GTG>GTA	p.V39V		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	39						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						AAGATGAAGTGAAGTGCAAAT	0.373			NA											10	71					0	0	0.001855	0	0
HRSP12	10247	broad.mit.edu	37	8	99120937	99120937	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:99120937C>G	uc003yii.1	-	2	202	c.108G>C	c.(106-108)CAG>CAC	p.Q36H		NM_005836	NP_005827	P52758	UK114_HUMAN	heat-responsive protein 12	36					regulation of translational termination	nucleus	endonuclease activity			ovary(1)	1	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			CCATGCCTATCTGTCCTGAAA	0.378			NA											26	135					0	0	0.003954	0	0
UTP23	84294	broad.mit.edu	37	8	117782546	117782546	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:117782546G>C	uc003yoc.2	+	2	405	c.304G>C	c.(304-306)GAA>CAA	p.E102Q		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	102					rRNA processing	nucleolus					0						GAGTGGATCAGAATGTCTGCT	0.393			NA											15	173					0	0	0.003163	0	0
UTP23	84294	broad.mit.edu	37	8	117783724	117783724	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:117783724G>C	uc003yoc.2	+	3	494	c.393G>C	c.(391-393)AAG>AAC	p.K131N		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	131					rRNA processing	nucleolus					0						AAGTAAAAAAGAAGCCTGGAG	0.333			NA											24	161					0	0	0.00278	0	0
DEPDC6	64798	broad.mit.edu	37	8	121061886	121061886	+	Silent	SNP	G	G	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:121061886G>A	uc003yow.3	+	9	1360	c.1173G>A	c.(1171-1173)CTG>CTA	p.L391L	DEPDC6_uc011lid.1_Silent_p.L290L	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	391	PDZ.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGAGCAATCTGATTCTGACGG	0.547			NA											24	141					0	0	0.007291	0	0
TAF1L	138474	broad.mit.edu	37	9	32635343	32635343	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:32635343C>T	uc003zrg.1	-	1	325	c.235G>A	c.(235-237)GAA>AAA	p.E79K	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	79					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCCGTGAGTTCAGTGATTAGG	0.527			NA											37	58					0	0	0.004289	0	0
SPIN1	10927	broad.mit.edu	37	9	91041471	91041471	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:91041471G>T	uc010mqj.2	+	2	517	c.17G>T	c.(16-18)GGA>GTA	p.G6V	SPIN1_uc004apy.2_Missense_Mutation_p.G6V|SPIN1_uc004apz.2_Missense_Mutation_p.G6V|SPIN1_uc010mqk.2_Missense_Mutation_p.G6V	NM_006717	NP_006708	Q9Y657	SPIN1_HUMAN	spindlin	6					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0						ACCCCATTCGGAAAGACACCT	0.388			NA											8	17					5.18039e-06	5.3404e-06	0.00308	1	0
SMC2	10592	broad.mit.edu	37	9	106864469	106864469	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:106864469G>C	uc004bbv.2	+	8	1153	c.865G>C	c.(865-867)GAT>CAT	p.D289H	SMC2_uc004bbu.1_Missense_Mutation_p.D289H|SMC2_uc004bbw.2_Missense_Mutation_p.D289H|SMC2_uc011lvl.1_Missense_Mutation_p.D289H|SMC2_uc010mtg.1_Missense_Mutation_p.D144H|SMC2_uc010mth.1_Missense_Mutation_p.D239H|SMC2_uc004bbx.2_Missense_Mutation_p.D289H	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	289	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						AAAAAGAAAAGATAAGGTCTG	0.269			NA											9	27					0	0	0.006214	0	0
MUSK	4593	broad.mit.edu	37	9	113562746	113562746	+	Silent	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:113562746C>A	uc004bey.2	+	14	2186	c.2088C>A	c.(2086-2088)CCC>CCA	p.P696P	MUSK_uc004bez.1_Silent_p.P276P	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	696	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						GGCCCCCACCCCTCTCCTGTG	0.577			NA											71	75					1.07363e-35	1.53294e-35	0.01441	1	0
OR1N2	138882	broad.mit.edu	37	9	125315631	125315631	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:125315631C>T	uc011lyx.1	+	1	183	c.183C>T	c.(181-183)CTC>CTT	p.L61L		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	61	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GGAACCTGCTCATTATCCTGG	0.522			NA											36	85					0	0	0.003271	0	0
OR1B1	347169	broad.mit.edu	37	9	125391523	125391523	+	Missense_Mutation	SNP	G	G	A	rs140947515	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:125391523G>A	uc011lyz.1	-	1	292	c.292C>T	c.(292-294)CGC>TGC	p.R98C		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCAAGCAGCGGGCAGCAGGA	0.517			NA											14	24					0	0	0.00245	0	0
OR1K1	392392	broad.mit.edu	37	9	125563287	125563287	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:125563287C>A	uc011lze.1	+	1	886	c.886C>A	c.(886-888)CGC>AGC	p.R296S		NM_080859	NP_543135	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTCTGGAATCGCGATGTACA	0.607			NA											27	38					2.48779e-11	2.8755e-11	0.005443	1	0
FAM69B	138311	broad.mit.edu	37	9	139617467	139617467	+	Silent	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr9:139617467C>G	uc004cik.2	+	5	631	c.537C>G	c.(535-537)CTC>CTG	p.L179L	FAM69B_uc004cil.2_Silent_p.L92L|SNHG7_uc004cim.2_RNA	NM_152421	NP_689634	Q5VUD6	FA69B_HUMAN	hypothetical protein LOC138311	179	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		AGGTCCTGCTCATGGCTGACT	0.607			NA											11	22					0	0	0.001855	0	0
PLCXD1	55344	broad.mit.edu	37	X	215942	215942	+	Silent	SNP	C	C	T			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chrX:215942C>T	uc004cpc.2	+	7	1224	c.912C>T	c.(910-912)ATC>ATT	p.I304I	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	304					intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGACTTCATCGGCGCAGACG	0.647			NA											10	38					0	0	0.008291	0	0
MAGEC3	139081	broad.mit.edu	37	X	140926162	140926162	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chrX:140926162T>C	uc011mwp.1	+	1	61	c.61T>C	c.(61-63)TGG>CGG	p.W21R		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	21										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTAGGCCAGTGGGTGAAAAA	0.522			NA											32	3					0	0	0.012213	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304067	151304067	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chrX:151304067C>G	uc004ffk.2	-	5	434	c.26G>C	c.(25-27)CGC>CCC	p.R9P	MAGEA10_uc004ffl.2_Missense_Mutation_p.R9P	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	9											0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGCATGCAGCGCTGACGCTT	0.597			NA											38	12					0	0	0.004878	0	0
FASN	2194	broad.mit.edu	37	17	80042538	80042539	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr17:80042538_80042539insC	uc002kdu.2	-	27	4735_4736	c.4618_4619insG	c.(4618-4620)GACfs	p.D1540fs	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1540					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGAGGACAGGTCCCCCCGGGTG	0.673	Colon(59;314 1043 11189 28578 32273)		NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1223056	1223069	+	Frame_Shift_Del	DEL	GTGGCGCAGCATGA	GTGGCGCAGCATGA	-	rs121913325		TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	GTGGCGCAGCATGA	GTGGCGCAGCATGA	-	-	GTGGCGCAGCATGA	GTGGCGCAGCATGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr19:1223056_1223069delGTGGCGCAGCATGA	uc002lrl.1	+	8	2108_2121	c.993_1006delGTGGCGCAGCATGA	c.(991-1008)CGGTGGCGCAGCATGACTfs	p.R331fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	331_336					anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.W332*(3)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGGACCGGTGGCGCAGCATGACTGTGGTGCC	0.617		W332*(NCIH23_LUNG)	14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			12	3	---	---	---	---	NA	NA	NA	NA	NA
HEG1	57493	broad.mit.edu	37	3	124731518	124731519	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr3:124731518_124731519insA	uc003ehs.3	-	6	2972_2973	c.2904_2905insT	c.(2902-2907)TTTGCTfs	p.F968fs	HEG1_uc011bke.1_Frame_Shift_Ins_p.F1068fs	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	968_969	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						CTCTGAACAGCAAAGGTGGCAG	0.525			NA											17	16	---	---	---	---	NA	NA	NA	NA	NA
PTTG2	10744	broad.mit.edu	37	4	37962391	37962402	+	In_Frame_Del	DEL	AGAAATAGAAAA	AGAAATAGAAAA	-			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	AGAAATAGAAAA	AGAAATAGAAAA	-	-	AGAAATAGAAAA	AGAAATAGAAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr4:37962391_37962402delAGAAATAGAAAA	uc011bye.1	+	1	336_347	c.336_347delAGAAATAGAAAA	c.(334-348)CCAGAAATAGAAAAA>CCA	p.EIEK113del	TBC1D1_uc003gtb.2_Intron|TBC1D1_uc011byd.1_Intron|TBC1D1_uc010ifd.2_Intron	NM_006607	NP_006598	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	113_116					chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding				0						ACGCCTATCCAGAAATAGAAAAATTCTTTCCC	0.439			NA											31	156	---	---	---	---	NA	NA	NA	NA	NA
ARAP3	64411	broad.mit.edu	37	5	141052424	141052424	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr5:141052424delG	uc003llm.2	-	8	1240	c.1162delC	c.(1162-1164)CGGfs	p.R388fs	ARAP3_uc011dbe.1_Frame_Shift_Del_p.R50fs|ARAP3_uc003lln.2_Frame_Shift_Del_p.R310fs|ARAP3_uc003llo.1_Frame_Shift_Del_p.R388fs	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	388					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TGGGGGGGCCGGGGGTGGCCC	0.672			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
EYA1	2138	broad.mit.edu	37	8	72234058	72234067	+	Frame_Shift_Del	DEL	CCATATGCAG	CCATATGCAG	-	rs141779040	byFrequency	TCGA-78-7167-01A-11D-2063-08	TCGA-78-7167-11A-01D-2063-08	CCATATGCAG	CCATATGCAG	-	-	CCATATGCAG	CCATATGCAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	47f8509a-3dd2-4750-b291-035218152168	3ca799b9-0f69-41aa-a0b5-e9ee6a1ec7da	g.chr8:72234058_72234067delCCATATGCAG	uc003xys.3	-	5	607_616	c.320_329delCTGCATATGG	c.(319-330)GCTGCATATGGGfs	p.A107fs	EYA1_uc003xyr.3_Frame_Shift_Del_p.A107fs|EYA1_uc003xyt.3_Frame_Shift_Del_p.A74fs|EYA1_uc010lzf.2_Frame_Shift_Del_p.A34fs|EYA1_uc003xyu.2_Frame_Shift_Del_p.A107fs|EYA1_uc011lfe.1_Frame_Shift_Del_p.A106fs|EYA1_uc003xyv.2_Intron	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	107_110					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGTGTTTGCCCATATGCAGCCATAGTTTG	0.462			NA											11	114	---	---	---	---	NA	NA	NA	NA	NA
