Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	979595	979595	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:979595G>T	uc001ack.1	+	11	2156	c.2106G>T	c.(2104-2106)CCG>CCT	p.P702P		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	702	Kazal-like 8.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		AGGACGGGCCGTGTGTCTGTG	0.711			NA											19	78					7.41877e-09	1.12974e-08	0.001882	1	0
MIB2	142678	broad.mit.edu	37	1	1563448	1563448	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:1563448G>T	uc001agg.2	+	14	2031	c.1904G>T	c.(1903-1905)GGA>GTA	p.G635V	MIB2_uc001agh.2_Missense_Mutation_p.G621V|MIB2_uc001agi.2_Missense_Mutation_p.G631V|MIB2_uc001agj.2_Missense_Mutation_p.G476V|MIB2_uc001agk.2_Missense_Mutation_p.G570V|MIB2_uc001agl.1_Missense_Mutation_p.G591V|MIB2_uc001agm.2_Missense_Mutation_p.G512V|MIB2_uc010nyq.1_Missense_Mutation_p.G591V|MIB2_uc009vkh.2_Missense_Mutation_p.G441V|MIB2_uc001agn.2_Missense_Mutation_p.G267V|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	635	ANK 4.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCGGGCACTGGAGCCAGCGGC	0.642			NA											9	28					5.4927e-09	8.40171e-09	0.004482	1	0
MORN1	79906	broad.mit.edu	37	1	2317245	2317245	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:2317245C>A	uc001ajb.1	-	5	470	c.449_splice	c.e5+1	p.Q150_splice	MORN1_uc009vld.2_Splice_Site_p.Q126_splice|MORN1_uc001ajd.1_Splice_Site_p.Q150_splice|MORN1_uc010nyy.1_Splice_Site_p.R93_splice	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1											ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		CTCATACTCACTGAAAGAGCA	0.582			NA											17	61					1.96292e-10	3.16092e-10	0.001523	1	0
PLCH2	9651	broad.mit.edu	37	1	2428140	2428140	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:2428140G>T	uc001aji.1	+	14	2204	c.1930G>T	c.(1930-1932)GAG>TAG	p.E644*	PLCH2_uc010nyz.1_Nonsense_Mutation_p.E432*|PLCH2_uc009vle.1_Nonsense_Mutation_p.E432*|PLCH2_uc001ajj.1_Nonsense_Mutation_p.E432*|PLCH2_uc001ajk.1_Nonsense_Mutation_p.E432*|PLCH2_uc001ajl.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	644	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CATAGAGATGGAGGGTGAGTG	0.672			NA											7	4					0.00621372	0.00712032	0.006214	1	0
CAMTA1	23261	broad.mit.edu	37	1	7527927	7527927	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:7527927C>T	uc001aoi.2	+	6	683	c.476C>T	c.(475-477)CCC>CTC	p.P159L		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	159	CG-1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCCATCATCCCCACCTTCCAC	0.473			NA											32	181					0	0	0.003271	0	0
GPR157	80045	broad.mit.edu	37	1	9188741	9188741	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:9188741G>A	uc001apq.1	-	1	489	c.346C>T	c.(346-348)CGC>TGC	p.R116C	GPR157_uc010oad.1_Missense_Mutation_p.R116C|GPR157_uc001apr.2_Missense_Mutation_p.R116C|GPR157_uc001aps.2_Missense_Mutation_p.S164L	NM_024980	NP_079256	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	116	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		CGATCTGTGCGAGGCCCGCGC	0.672			NA											4	33					0	0	0.000602	0	0
SLC25A33	84275	broad.mit.edu	37	1	9613776	9613776	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:9613776A>G	uc001apw.2	+	2	372	c.149A>G	c.(148-150)TAC>TGC	p.Y50C	SLC25A33_uc001apx.2_5'UTR	NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	mitochondrial carrier protein MGC4399	50	Helical; Name=2; (Potential).|Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CGGACAGTCTACTATCCTCAG	0.478			NA											21	46					0	0	0.002299	0	0
AADACL4	343066	broad.mit.edu	37	1	12725977	12725977	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:12725977G>T	uc001auf.2	+	4	455	c.455G>T	c.(454-456)CGC>CTC	p.R152L		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	152	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TTTAGGTACCGCAAGCTTCCT	0.512			NA											17	56					5.3912e-06	7.26217e-06	0.006122	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12885040	12885040	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:12885040G>A	uc001auk.2	-	4	1267	c.1071C>T	c.(1069-1071)AAC>AAT	p.N357N		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	357	LRR 6.										0						GGCTCAGCAGGTTCTCCAGGG	0.537			NA											29	392					0	0	0.002096	0	0
CLCNKA	1187	broad.mit.edu	37	1	16350360	16350360	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:16350360C>A	uc001axu.2	+	3	246	c.166C>A	c.(166-168)CTC>ATC	p.L56I	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.L56I|CLCNKA_uc010obw.1_Missense_Mutation_p.L56I|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	56	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CCTGATGACCCTCGGGGTGCT	0.597			NA											8	42					5.4927e-09	8.40171e-09	0.004482	1	0
NBPF1	55672	broad.mit.edu	37	1	16902855	16902855	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:16902855C>G	uc009vos.1	-	19	2914	c.2026G>C	c.(2026-2028)GAT>CAT	p.D676H	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.D134H|NBPF1_uc010oce.1_Missense_Mutation_p.D405H	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	676						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTGGCTCATCCGGAGTGAGG	0.572			NA											28	685					0	0	0.00278	0	0
CROCC	9696	broad.mit.edu	37	1	17263312	17263312	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:17263312G>C	uc001azt.2	+	9	1206	c.1137G>C	c.(1135-1137)AAG>AAC	p.K379N	CROCC_uc009voy.1_Missense_Mutation_p.K82N|CROCC_uc009voz.1_Missense_Mutation_p.K142N	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	379	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TCCGCGAGAAGGACCTGGCGC	0.672			NA											3	64					0	0	0.004672	0	0
PADI6	353238	broad.mit.edu	37	1	17721512	17721512	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:17721512C>A	uc001bak.1	+	13	1403	c.1403C>A	c.(1402-1404)CCG>CAG	p.P468Q		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	460					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GTCCAAGCGCCGGTGGAGCTC	0.537			NA											16	37					2.31682e-05	2.98321e-05	0.003163	1	0
AKR7A3	22977	broad.mit.edu	37	1	19610580	19610580	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:19610580C>T	uc001bbv.1	-	6	821	c.744G>A	c.(742-744)GTG>GTA	p.V248V		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	248					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCCTTCTCCACCAGGGCAA	0.642			NA											5	36					0	0	0.000602	0	0
KIF17	57576	broad.mit.edu	37	1	21042034	21042034	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:21042034C>G	uc001bdr.3	-	2	448	c.330G>C	c.(328-330)CAG>CAC	p.Q110H	KIF17_uc001bds.3_Missense_Mutation_p.Q110H	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	110	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGATGCCTCTCTGGGAGGGCG	0.662			NA											5	38					0	0	0.000602	0	0
HP1BP3	50809	broad.mit.edu	37	1	21072078	21072078	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:21072078G>A	uc001bdw.1	-	12	1465	c.1325C>T	c.(1324-1326)TCA>TTA	p.S442L	HP1BP3_uc001bdv.1_Missense_Mutation_p.S404L|HP1BP3_uc010odh.1_Missense_Mutation_p.S404L|HP1BP3_uc001bdy.1_Missense_Mutation_p.S442L|HP1BP3_uc010odf.1_Missense_Mutation_p.S101L|HP1BP3_uc010odg.1_Missense_Mutation_p.S290L	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	442					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GTCTTCTTCTGATGACTCATC	0.443			NA											7	63					0	0	0.00308	0	0
CD52	1043	broad.mit.edu	37	1	26644547	26644547	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:26644547C>A	uc001bmc.2	+	1	137	c.39C>A	c.(37-39)CTC>CTA	p.L13L	UBXN11_uc001bma.2_5'UTR|CD52_uc009vsg.1_RNA	NM_001803	NP_001794	P31358	CD52_HUMAN	CD52 antigen precursor	13					elevation of cytosolic calcium ion concentration|respiratory burst	anchored to membrane|integral to plasma membrane|membrane fraction					0		all_cancers(24;5.02e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.56e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0137)|READ - Rectum adenocarcinoma(331;0.0649)	Alemtuzumab(DB00087)	CCATCAGCCTCCTGGTTATGG	0.542			NA											10	69					0.00829132	0.00946874	0.008291	1	0
PHC2	1912	broad.mit.edu	37	1	33799778	33799778	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:33799778A>T	uc001bxg.1	-	9	1725	c.1671T>A	c.(1669-1671)AAT>AAA	p.N557K	PHC2_uc001bxh.1_Missense_Mutation_p.N529K|PHC2_uc009vuh.1_Missense_Mutation_p.N558K|PHC2_uc001bxe.1_Missense_Mutation_p.N22K|PHC2_uc001bxf.1_Intron	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	557					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GTGGTGGTTTATTCTCACCAT	0.572			NA											11	78					0	0	0.008291	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33945118	33945119	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:33945118_33945119TG>CT	uc001bxj.3	+	2	396_397	c.229_230TG>CT	c.(229-231)TGT>CTT	p.C77L	ZSCAN20_uc001bxk.2_Missense_Mutation_p.C77L|ZSCAN20_uc009vui.2_Missense_Mutation_p.C77L	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	77	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGCTCTCTGCTGTCGTTGGCTG	0.614			NA											5	42					0	0	0.004672	0	0
CSMD2	114784	broad.mit.edu	37	1	34276415	34276415	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:34276415G>T	uc001bxn.1	-	10	1284	c.1255C>A	c.(1255-1257)CCC>ACC	p.P419T	CSMD2_uc001bxm.1_Missense_Mutation_p.P459T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	419	CUB 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGGAAATTGGGGGAGGTGATG	0.537			NA											21	89					2.27731e-05	2.94362e-05	0.001882	1	0
ZMYM4	9202	broad.mit.edu	37	1	35884120	35884120	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:35884120T>C	uc001byt.2	+	29	4466	c.4386T>C	c.(4384-4386)ACT>ACC	p.T1462T	ZMYM4_uc009vuu.2_Silent_p.T1430T|ZMYM4_uc001byu.2_Silent_p.T1138T|ZMYM4_uc009vuv.2_Silent_p.T1201T	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1462					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGAGAATACTGACAATCCAC	0.413			NA											7	51					0	0	0.001984	0	0
EIF2C1	26523	broad.mit.edu	37	1	36349034	36349034	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:36349034A>T	uc001bzl.2	+	1	225	c.12A>T	c.(10-12)GGA>GGT	p.G4G	EIF2C1_uc001bzk.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	4					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGGAAGCGGGACCCTCGGGAG	0.637			NA											9	40					0	0	0.006214	0	0
MEAF6	64769	broad.mit.edu	37	1	37979099	37979099	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:37979099T>C	uc001cbg.1	-	2	148	c.131A>G	c.(130-132)GAG>GGG	p.E44G	MEAF6_uc001cbd.1_Missense_Mutation_p.E22G|MEAF6_uc001cbe.1_Missense_Mutation_p.E44G|MEAF6_uc009vvd.1_RNA|MEAF6_uc001cbf.1_RNA|MEAF6_uc001cbh.1_Missense_Mutation_p.E44G	NM_022756	NP_073593	Q9HAF1	EAF6_HUMAN	MYST/Esa1-associated factor 6	44	Potential.				histone H2A acetylation|histone H3-K14 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|NuA4 histone acetyltransferase complex|nucleolus	protein binding				0						GTAGCTTCCCTCAAAAGCATA	0.418			NA											32	106					0	0	0.002096	0	0
MACF1	23499	broad.mit.edu	37	1	39851375	39851375	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:39851375G>C	uc010oiu.1	+	21	9569	c.9438G>C	c.(9436-9438)CTG>CTC	p.L3146L	MACF1_uc010ois.1_Silent_p.L2644L|MACF1_uc001cda.1_Silent_p.L2531L|MACF1_uc001cdc.1_Silent_p.L1710L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4711					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GACAACGGCTGAGTGTCCAGT	0.512			NA											7	45					0	0	0.00308	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048667	42048667	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:42048667T>C	uc001cgz.3	-	4	3015	c.1802A>G	c.(1801-1803)TAC>TGC	p.Y601C	HIVEP3_uc001cha.3_Missense_Mutation_p.Y601C|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	601	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTCAGAACTGTATTCCCCTCC	0.572			NA											24	46					0	0	0.00333	0	0
PTCH2	8643	broad.mit.edu	37	1	45292685	45292685	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:45292685C>A	uc010olf.1	-	17	2596	c.2584G>T	c.(2584-2586)GTG>TTG	p.V862L	PTCH2_uc010olg.1_Missense_Mutation_p.V560L	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	862	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CTCACCCACACGGTCAGCCCC	0.617			NA							Basal_Cell_Nevus_syndrome				13	134					9.31168e-06	1.24063e-05	0.001855	1	0
EIF2B3	8891	broad.mit.edu	37	1	45407298	45407298	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:45407298C>A	uc001cmt.1	-	4	461	c.334G>T	c.(334-336)GTT>TTT	p.V112F	EIF2B3_uc001cmu.1_Missense_Mutation_p.V112F|EIF2B3_uc001cmv.1_Missense_Mutation_p.V112F|EIF2B3_uc001cmw.2_Missense_Mutation_p.V112F	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	112					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGTAAGGCAACGTCTGTTATC	0.418	Colon(26;357 658 2581 11857 12657)		NA											15	71					6.94344e-10	1.10095e-09	0.006122	1	0
MUTYH	4595	broad.mit.edu	37	1	45798843	45798843	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:45798843C>A	uc001cnm.2	-	5	596	c.380_splice	c.e5-1	p.V127_splice	MUTYH_uc009vxn.2_Intron|MUTYH_uc001cnf.2_Splice_Site_p.V102_splice|MUTYH_uc009vxo.2_Splice_Site_p.V102_splice|MUTYH_uc001cng.2_Splice_Site_p.V113_splice|MUTYH_uc001cnj.2_Splice_Site_p.V10_splice|MUTYH_uc001cni.2_Splice_Site_p.V102_splice|MUTYH_uc001cnh.2_Splice_Site_p.V103_splice|MUTYH_uc001cno.2_Splice_Site_p.V10_splice|MUTYH_uc001cnk.2_Intron|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Splice_Site_p.V116_splice|MUTYH_uc009vxp.2_Splice_Site_p.V130_splice|MUTYH_uc001cnn.2_Splice_Site_p.V117_splice	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1						depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					GAGACCCACACTGGGGGAAAG	0.617			NA	Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				14	64					1.62849e-17	3.03337e-17	0.004007	1	0
CCDC163P	126661	broad.mit.edu	37	1	45962293	45962293	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:45962293G>A	uc001cnw.2	-	4	630	c.265C>T	c.(265-267)CAG>TAG	p.Q89*	CCDC163P_uc001cnt.2_RNA|CCDC163P_uc001cnu.2_RNA|CCDC163P_uc009vxt.1_Nonsense_Mutation_p.Q89*|CCDC163P_uc001cnv.2_RNA|CCDC163P_uc009vxu.1_RNA	NM_001102601	NP_001096071			hypothetical protein LOC126661												0						TCCTGGTGCTGGCCTGCAGAT	0.542			NA											4	6					0	0	0.000248	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666530	50666531	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:50666530_50666531CC>AA	uc001csb.2	+	7	1091_1092	c.823_824CC>AA	c.(823-825)CCA>AAA	p.P275K	ELAVL4_uc001cry.3_Missense_Mutation_p.P264K|ELAVL4_uc001crz.3_Missense_Mutation_p.P261K|ELAVL4_uc001csa.3_Missense_Mutation_p.P278K|ELAVL4_uc001csc.3_Missense_Mutation_p.P261K|ELAVL4_uc010omz.1_Missense_Mutation_p.P266K	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	275					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CAGGTTCTCCCCAATTACCATT	0.54			NA											14	110					0	0	0.004672	0	0
TTC39A	22996	broad.mit.edu	37	1	51767347	51767347	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:51767347T>C	uc001csl.2	-	12	1163	c.1058A>G	c.(1057-1059)CAC>CGC	p.H353R	TTC39A_uc001csk.2_Missense_Mutation_p.H318R|TTC39A_uc010ond.1_Missense_Mutation_p.H290R|TTC39A_uc010one.1_Missense_Mutation_p.H317R|TTC39A_uc010onf.1_Missense_Mutation_p.H321R|TTC39A_uc001csn.2_Missense_Mutation_p.H352R|TTC39A_uc001cso.1_3'UTR|TTC39A_uc009vyy.1_Missense_Mutation_p.H290R	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	353							binding			skin(1)	1						GTAGCACATGTGGTGGAACTG	0.607			NA											12	22					0	0	0.000978	0	0
NRD1	4898	broad.mit.edu	37	1	52301822	52301822	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:52301822C>T	uc001ctc.3	-	5	1219	c.897G>A	c.(895-897)CTG>CTA	p.L299L	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Silent_p.L231L|NRD1_uc001cte.2_Silent_p.L167L|NRD1_uc001ctf.2_Silent_p.L231L|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Silent_p.L99L	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	230					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AAAAGTGTGCCAGCCCCGGCA	0.418			NA											16	48					0	0	0.004007	0	0
CC2D1B	200014	broad.mit.edu	37	1	52824708	52824708	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:52824708G>A	uc001ctq.1	-	11	1386	c.1248C>T	c.(1246-1248)CGC>CGT	p.R416R	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_Silent_p.R107R	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	416										ovary(2)	2						CCTTGGCAATGCGCTCATGCA	0.662			NA											7	20					0	0	0.001984	0	0
C8A	731	broad.mit.edu	37	1	57333306	57333306	+	Silent	SNP	C	C	G	rs142045980		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:57333306C>G	uc001cyo.2	+	2	234	c.102C>G	c.(100-102)CCC>CCG	p.P34P		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	34					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CAGCTACACCCGCAGCAGTTA	0.453			NA											5	32					0	0	0.000602	0	0
FOXD3	27022	broad.mit.edu	37	1	63789224	63789224	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:63789224C>G	uc001dax.2	+	1	495	c.495C>G	c.(493-495)AGC>AGG	p.S165R		NM_012183	NP_036315	Q9UJU5	FOXD3_HUMAN	forkhead box D3	165	Fork-head.				axon extension involved in axon guidance|branching involved in ureteric bud morphogenesis|cartilage development|embryonic placenta development|enteric nervous system development|iridophore differentiation|kidney development|lateral line nerve glial cell development|melanocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development|trophectodermal cell differentiation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						TGACCCTGAGCGGCATCTGCG	0.587	Pancreas(68;276 1750 11966 31252)		NA											13	77					0	0	0.001855	0	0
SLC44A5	204962	broad.mit.edu	37	1	75672357	75672357	+	Missense_Mutation	SNP	C	C	A	rs78856933	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:75672357C>A	uc001dgu.2	-	24	2239	c.2095G>T	c.(2095-2097)GTA>TTA	p.V699L	SLC44A5_uc001dgt.2_Intron|SLC44A5_uc001dgs.2_Intron|SLC44A5_uc001dgr.2_Intron|SLC44A5_uc010oqz.1_Intron|SLC44A5_uc010ora.1_Missense_Mutation_p.V693L|SLC44A5_uc010orb.1_Missense_Mutation_p.V569L	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	699	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TTAGGGGTTACGAAGTAGGGT	0.413			NA											25	56					8.58068e-18	1.60723e-17	0.007291	1	0
MSH4	4438	broad.mit.edu	37	1	76345788	76345788	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:76345788G>A	uc001dhd.1	+	13	1772	c.1731G>A	c.(1729-1731)ATG>ATA	p.M577I		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	577					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TAATTAAAATGAATGAAAGAT	0.269			NA						MMR					4	49					0	0	0.000248	0	0
ZZZ3	26009	broad.mit.edu	37	1	78034024	78034024	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:78034024C>A	uc001dhq.2	-	13	2935	c.2459G>T	c.(2458-2460)GGC>GTC	p.G820V	ZZZ3_uc001dhr.2_Missense_Mutation_p.G326V|ZZZ3_uc001dhp.2_Missense_Mutation_p.G819V	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	820	ZZ-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TACCTTAAAGCCCACATGTTG	0.214			NA											8	67					0.000442599	0.000529778	0.006214	1	0
LPHN2	23266	broad.mit.edu	37	1	82450396	82450396	+	Splice_Site	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:82450396G>C	uc001dit.3	+	19	3541	c.3360_splice	c.e19+1	p.Q1120_splice	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Splice_Site_p.Q1120_splice|LPHN2_uc001div.2_Splice_Site_p.Q1120_splice|LPHN2_uc009wcd.2_Splice_Site_p.Q1120_splice|LPHN2_uc001diw.2_Splice_Site_p.Q704_splice	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGGCACACAGGTAACAAAGAG	0.428			NA											6	52					0	0	0.001168	0	0
PRKACB	5567	broad.mit.edu	37	1	84668407	84668407	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:84668407A>T	uc001djj.2	+	8	948	c.684A>T	c.(682-684)CTA>CTT	p.L228L	PRKACB_uc001djl.2_Silent_p.L275L|PRKACB_uc010ort.1_Silent_p.L235L|PRKACB_uc001djn.2_Silent_p.L232L|PRKACB_uc010oru.1_Silent_p.L216L|PRKACB_uc001djp.2_Silent_p.L234L|PRKACB_uc001djq.2_Silent_p.L198L|PRKACB_uc010orv.1_Silent_p.L215L|PRKACB_uc001dji.2_Silent_p.L228L|PRKACB_uc001djk.2_Silent_p.L275L|PRKACB_uc009wcf.1_Silent_p.L234L	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	228	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TAGGAGTGCTAATCTATGAAA	0.353			NA											12	71					0	0	0.001855	0	0
WDR63	126820	broad.mit.edu	37	1	85547082	85547082	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:85547082T>G	uc001dkt.2	+	4	460	c.269T>G	c.(268-270)GTC>GGC	p.V90G	WDR63_uc009wcl.2_Missense_Mutation_p.V90G	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	90										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TTCCACCCAGTCAAAAAAATT	0.383			NA											18	50					0	0	0.007413	0	0
COL24A1	255631	broad.mit.edu	37	1	86289273	86289273	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:86289273C>A	uc001dlj.2	-	45	3778	c.3736_splice	c.e45-1	p.G1246_splice	COL24A1_uc001dli.2_Splice_Site_p.G382_splice|COL24A1_uc010osd.1_Splice_Site_p.G546_splice|COL24A1_uc001dlk.2_Splice_Site|COL24A1_uc010ose.1_Splice_Site|COL24A1_uc010osf.1_Splice_Site	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor						cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGGTTCGCCCTTTAGTAGAA	0.333			NA											6	39					4.096e-09	6.33747e-09	0.001168	1	0
COL24A1	255631	broad.mit.edu	37	1	86453338	86453338	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:86453338C>A	uc001dlj.2	-	20	2353	c.2311_splice	c.e20-1	p.G771_splice	COL24A1_uc010osd.1_Splice_Site_p.G71_splice|COL24A1_uc001dlk.2_Splice_Site|COL24A1_uc010ose.1_Splice_Site|COL24A1_uc010osf.1_Splice_Site	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor						cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGGAAAACCCTAGGGAATAT	0.358			NA											12	60					1.61879e-10	2.61303e-10	0.001368	1	0
CLCA2	9635	broad.mit.edu	37	1	86898153	86898153	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:86898153T>C	uc001dlr.3	+	5	848	c.686T>C	c.(685-687)ATC>ACC	p.I229T		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	229	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TGCACCTTTATCTACAATAGC	0.378	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											28	82					0	0	0.008361	0	0
GBP6	163351	broad.mit.edu	37	1	89848344	89848344	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:89848344G>T	uc001dnf.2	+	8	1548	c.1274G>T	c.(1273-1275)AGT>ATT	p.S425I	GBP6_uc010ost.1_Missense_Mutation_p.S295I	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	425							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		TCAGCAGGAAGTTTCTCTGTT	0.443			NA											15	58					1.05317e-09	1.65622e-09	0.00245	1	0
LRRC8C	84230	broad.mit.edu	37	1	90178811	90178811	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:90178811G>C	uc001dnl.3	+	3	924	c.682G>C	c.(682-684)GGG>CGG	p.G228R		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	228						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		ATCCACTGCAGGGGCTCTGGA	0.453			NA											7	51					0	0	0.001984	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94670703	94670703	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:94670703G>C	uc001dqj.3	-	7	980	c.611C>G	c.(610-612)TCT>TGT	p.S204C	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.S204C	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	204					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CAGCTCGATAGAGTCAGTGTT	0.338			NA											4	28					0	0	0.000248	0	0
COL11A1	1301	broad.mit.edu	37	1	103444295	103444295	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:103444295C>A	uc001dul.2	-	35	3041	c.2723G>T	c.(2722-2724)GGC>GTC	p.G908V	COL11A1_uc001duk.2_Missense_Mutation_p.G104V|COL11A1_uc001dum.2_Missense_Mutation_p.G920V|COL11A1_uc001dun.2_Missense_Mutation_p.G869V|COL11A1_uc009weh.2_Missense_Mutation_p.G792V	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	908	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGGGCCATCGCCACCTGAAGT	0.388			NA											22	171					5.26018e-13	9.08023e-13	0.001882	1	0
FAM40A	85369	broad.mit.edu	37	1	110584481	110584481	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:110584481T>A	uc001dza.1	+	8	902	c.883T>A	c.(883-885)TTG>ATG	p.L295M	FAM40A_uc001dyz.1_Missense_Mutation_p.L200M|FAM40A_uc009wfp.1_Missense_Mutation_p.L119M	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	295						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		GAAGACAGTATTGGTGAGCAC	0.463			NA											15	99					0	0	0.004007	0	0
SPAG17	200162	broad.mit.edu	37	1	118596629	118596629	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:118596629A>T	uc001ehk.2	-	20	2878	c.2810T>A	c.(2809-2811)CTC>CAC	p.L937H		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	937						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		gaTTACCTTGAGAGAGCCTTC	0.174			NA											5	27					0	0	0.000602	0	0
HSD3B2	3284	broad.mit.edu	37	1	119965095	119965095	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:119965095G>A	uc001ehs.2	+	3	1744	c.971G>A	c.(970-972)AGT>AAT	p.S324N	HSD3B2_uc001eht.2_Missense_Mutation_p.S324N|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	324					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TTATCAAATAGTGTGTTCACC	0.498			NA											11	78					0	0	0.000978	0	0
ADAM30	11085	broad.mit.edu	37	1	120438236	120438236	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:120438236G>T	uc001eij.2	-	1	878	c.724C>A	c.(724-726)CAA>AAA	p.Q242K		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	242	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CGAACATCTTGAAAGTAGGTG	0.378			NA											22	51					3.5997e-14	6.3947e-14	0.002299	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144866652	144866652	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:144866652T>C	uc001elw.3	-	34	5881	c.5590A>G	c.(5590-5592)ATC>GTC	p.I1864V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.I1758V|PDE4DIP_uc001elv.3_Missense_Mutation_p.I871V|PDE4DIP_uc001ema.2_Missense_Mutation_p.I51V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1864	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGGTCATTGATGCAGATGGAT	0.577			NA	T	PDGFRB	MPD								38	254					0	0	0.005524	0	0
CHD1L	9557	broad.mit.edu	37	1	146759402	146759402	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:146759402G>T	uc001epm.3	+	19	2373	c.2310G>T	c.(2308-2310)GGG>GGT	p.G770G	uc001epp.2_Intron|CHD1L_uc001epn.3_Silent_p.G657G|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Silent_p.G676G|CHD1L_uc010ozp.1_Silent_p.G489G|CHD1L_uc001epo.3_Silent_p.G566G|CHD1L_uc009wji.2_Silent_p.G489G	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	770	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					AGCTGGCTGGGAAAATGAAAG	0.438			NA											12	84					1.61879e-10	2.61303e-10	0.001368	1	0
SV2A	9900	broad.mit.edu	37	1	149885321	149885321	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:149885321C>T	uc001etg.2	-	2	563	c.72G>A	c.(70-72)AAG>AAA	p.K24K	SV2A_uc001eth.2_Silent_p.K24K	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	24	Cytoplasmic (Potential).|Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGGCCGCATGCTTTTTGACTT	0.547			NA											20	110					0	0	0.001882	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058087	152058087	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:152058087C>A	uc001ezo.1	-	3	2136	c.2071G>T	c.(2071-2073)GGA>TGA	p.G691*		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	691							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCTCCCTTTCCAGGGAGCTGC	0.458			NA											33	171					2.80507e-11	4.64514e-11	0.002445	1	0
HRNR	388697	broad.mit.edu	37	1	152188335	152188335	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:152188335C>A	uc001ezt.1	-	3	5846	c.5770G>T	c.(5770-5772)GGT>TGT	p.G1924C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1924	21.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGCTGACCATAGCTGGAA	0.582			NA											35	828					4.74835e-14	8.39084e-14	0.002096	1	0
HRNR	388697	broad.mit.edu	37	1	152192096	152192096	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:152192096C>T	uc001ezt.1	-	3	2085	c.2009G>A	c.(2008-2010)GGG>GAG	p.G670E		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	670	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAAGAGTGCCCAAAATCGGA	0.592			NA											76	149					0	0	0.00361	0	0
LCE1D	353134	broad.mit.edu	37	1	152770363	152770363	+	Silent	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:152770363T>G	uc009wnp.2	+	2	136	c.93T>G	c.(91-93)CCT>CCG	p.P31P		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	31	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AATGTCCCCCTAAGTGCCCTC	0.552			NA											39	28					0	0	0.005524	0	0
TPM3	7170	broad.mit.edu	37	1	154163707	154163707	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:154163707C>T	uc001fec.1	-	2	313	c.198G>A	c.(196-198)AAG>AAA	p.K66K		NM_152263	NP_689476	P06753	TPM3_HUMAN	tropomyosin 3 isoform 1	65	By similarity.				cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)|skin(1)	34	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CCTGGGCATCCTTCAAAGCTT	0.478			NA	T	NTRK1|ALK	papillary thyroid|ALCL								6	105					0	0	0.001168	0	0
EFNA1	1942	broad.mit.edu	37	1	155104004	155104004	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:155104004G>T	uc001fhh.2	+	2	387	c.282G>T	c.(280-282)CGG>CGT	p.R94R	EFNA1_uc001fhi.2_Silent_p.R94R|EFNA1_uc009wpd.1_5'Flank	NM_004428	NP_004419	P20827	EFNA1_HUMAN	ephrin A1 isoform a precursor	94					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGTGCAACCGGCCCAGTGCCA	0.577			NA											10	14					2.17888e-05	2.81911e-05	0.006214	1	0
VHLL	391104	broad.mit.edu	37	1	156268966	156268966	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:156268966C>A	uc001fok.2	-	1	463	c.15G>T	c.(13-15)GCG>GCT	p.A5A		NM_001004319	NP_001004319	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	5					protein ubiquitination	nucleus				ovary(1)	1	Hepatocellular(266;0.158)					CCCCGTTCCCCGCTCTCCAGG	0.597			NA											25	74					7.76418e-22	1.5134e-21	0.005443	1	0
FCRL1	115350	broad.mit.edu	37	1	157773730	157773730	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:157773730G>A	uc001frg.2	-	3	337	c.224C>T	c.(223-225)GCC>GTC	p.A75V	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.A75V|FCRL1_uc001fri.2_Missense_Mutation_p.A75V|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	75	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTTCCACATGGCAGCGATCTG	0.547	GBM(54;482 1003 11223 30131 35730)		NA											32	91					0	0	0.001786	0	0
CD1A	909	broad.mit.edu	37	1	158226655	158226655	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:158226655C>G	uc001frt.2	+	4	1217	c.684C>G	c.(682-684)TTC>TTG	p.F228L		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	228	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TCTCAGGATTCTACCCAAAGC	0.597			NA											3	103					0	0	0.004672	0	0
OR10T2	128360	broad.mit.edu	37	1	158368842	158368842	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:158368842T>G	uc010pih.1	-	1	415	c.415A>C	c.(415-417)AAA>CAA	p.K139Q		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CCCAGCCTTTTGTTTATGATG	0.478			NA											9	80					0	0	0.008291	0	0
OR6Y1	391112	broad.mit.edu	37	1	158516985	158516985	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:158516985G>T	uc010pil.1	-	1	911	c.911C>A	c.(910-912)GCA>GAA	p.A304E		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCTGAGGGCTGCCTTTACTTC	0.438			NA											25	80					2.21704e-12	3.74055e-12	0.00278	1	0
SPTA1	6708	broad.mit.edu	37	1	158587833	158587833	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:158587833C>A	uc001fst.1	-	46	6743	c.6544G>T	c.(6544-6546)GAT>TAT	p.D2182Y		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2182	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTGACCCATCCAGAAAGTAA	0.348			NA											21	73					4.7796e-09	7.3444e-09	0.004656	1	0
OR6K3	391114	broad.mit.edu	37	1	158687493	158687493	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:158687493G>T	uc010pip.1	-	1	461	c.461C>A	c.(460-462)CCC>CAC	p.P154H		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	154	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					ACAGAGCCGGGGGGTCATGAT	0.522			NA											43	77					3.54909e-21	6.87796e-21	0.002852	1	0
ATP1A4	480	broad.mit.edu	37	1	160141191	160141191	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:160141191G>T	uc001fve.3	+	11	2121	c.1642G>T	c.(1642-1644)GCC>TCC	p.A548S	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.A51S	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	548	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTTCCAAAATGCCTACTTAGA	0.463			NA											27	44					1.42536e-11	2.38091e-11	0.004656	1	0
COPA	1314	broad.mit.edu	37	1	160265889	160265889	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:160265889C>G	uc009wti.2	-	22	2708	c.2314G>C	c.(2314-2316)GAG>CAG	p.E772Q	COPA_uc001fvv.3_Missense_Mutation_p.E781Q	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	772					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTAGGCTCTCAGCTTCTTCA	0.408			NA											3	92					0	0	0.000602	0	0
USF1	7391	broad.mit.edu	37	1	161011976	161011976	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:161011976C>A	uc001fxi.2	-	5	401	c.206G>T	c.(205-207)GGG>GTG	p.G69V	USF1_uc001fxj.2_Missense_Mutation_p.G10V	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	69					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ATCCAGCTGCCCCTCAGACAC	0.547			NA											17	44					7.05477e-17	1.30503e-16	0.00499	1	0
TOMM40L	84134	broad.mit.edu	37	1	161198044	161198044	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:161198044C>T	uc001fzd.2	+	7	782	c.553C>T	c.(553-555)CAC>TAC	p.H185Y	TOMM40L_uc010pkl.1_Missense_Mutation_p.H151Y|TOMM40L_uc009wue.2_Missense_Mutation_p.H67Y|TOMM40L_uc009wuf.1_RNA|TOMM40L_uc001fze.2_Missense_Mutation_p.H185Y	NM_032174	NP_115550	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40	185					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCTAGTTTATCACCGGCGGCC	0.592			NA									OREG0013943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	29					0	0	0.001368	0	0
PBX1	5087	broad.mit.edu	37	1	164769120	164769120	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:164769120A>T	uc001gct.2	+	4	953	c.695A>T	c.(694-696)GAT>GTT	p.D232V	PBX1_uc010pku.1_Missense_Mutation_p.D232V|PBX1_uc010pkv.1_Missense_Mutation_p.D149V|PBX1_uc001gcs.2_Missense_Mutation_p.D232V|PBX1_uc010pkw.1_Missense_Mutation_p.D122V	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	232					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						CGATTTCTGGATGCGCGGTGA	0.612			NA	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								5	16					0	0	0.001168	0	0
DUSP27	92235	broad.mit.edu	37	1	167095909	167095909	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:167095909G>T	uc001geb.1	+	5	1541	c.1541G>T	c.(1540-1542)AGG>ATG	p.R514M		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	514					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCAGGGAGCAGGGTGCGGGAG	0.587			NA											29	66					7.01153e-11	1.14001e-10	0.007291	1	0
F5	2153	broad.mit.edu	37	1	169510154	169510154	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:169510154G>A	uc001ggg.1	-	13	4319	c.4174C>T	c.(4174-4176)CCC>TCC	p.P1392S		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1392	2-24.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GCAAAGAGGGGCATCTCACTG	0.512			NA											43	212					0	0	0.007835	0	0
F5	2153	broad.mit.edu	37	1	169525938	169525938	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:169525938C>A	uc001ggg.1	-	6	1043	c.898G>T	c.(898-900)GTG>TTG	p.V300L	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	300	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCTGGGCCCACAGTCATATTT	0.473			NA											22	49					1.87028e-06	2.58414e-06	0.001882	1	0
RABGAP1L	9910	broad.mit.edu	37	1	174200322	174200322	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:174200322C>T	uc001gjx.2	+	4	566	c.371C>T	c.(370-372)CCT>CTT	p.P124L	RABGAP1L_uc009wwq.1_Missense_Mutation_p.P124L|RABGAP1L_uc001gjw.2_Missense_Mutation_p.P87L	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	124					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						GGTGGACTACCTGAAGAAGAT	0.383			NA											14	76					0	0	0.001855	0	0
TNN	63923	broad.mit.edu	37	1	175067500	175067500	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:175067500C>A	uc001gkl.1	+	9	2001	c.1888C>A	c.(1888-1890)CGG>AGG	p.R630R	TNN_uc010pmx.1_Silent_p.R541R	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	630	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGTGACTGACCGGGTGACAGA	0.532			NA											67	120					1.48005e-37	2.97116e-37	0.00361	1	0
TNN	63923	broad.mit.edu	37	1	175097288	175097288	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:175097288A>T	uc001gkl.1	+	14	3279	c.3166A>T	c.(3166-3168)ACC>TCC	p.T1056S		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1056	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTATCCACCACCCTCTCCAC	0.552			NA											16	36					0	0	0.004007	0	0
FAM5B	57795	broad.mit.edu	37	1	177199149	177199149	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:177199149A>T	uc001glf.2	+	2	449	c.137A>T	c.(136-138)CAT>CTT	p.H46L		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	46						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCCGAGCAGCATGCCTCCGTA	0.697			NA											15	33					0	0	0.00245	0	0
CACNA1E	777	broad.mit.edu	37	1	181741305	181741305	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:181741305C>T	uc001gow.2	+	37	5242	c.5077C>T	c.(5077-5079)CGC>TGC	p.R1693C	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1581C|CACNA1E_uc001gox.1_Missense_Mutation_p.R919C|CACNA1E_uc009wxt.2_Missense_Mutation_p.R919C	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1693	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGAGAACGAACGCTGCGGCAC	0.557			NA											25	96					0	0	0.00333	0	0
CACNA1E	777	broad.mit.edu	37	1	181741320	181741320	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:181741320C>A	uc001gow.2	+	37	5257	c.5092C>A	c.(5092-5094)CTG>ATG	p.L1698M	CACNA1E_uc009wxs.2_Missense_Mutation_p.L1586M|CACNA1E_uc001gox.1_Missense_Mutation_p.L924M|CACNA1E_uc009wxt.2_Missense_Mutation_p.L924M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1698	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGGCACCGATCTGGCCTACGT	0.552			NA											17	111					5.35267e-07	7.53525e-07	0.007413	1	0
ZNF648	127665	broad.mit.edu	37	1	182026967	182026967	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:182026967G>T	uc001goz.2	-	2	387	c.179C>A	c.(178-180)CCA>CAA	p.P60Q		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	60					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGTGTTACTGGGGAGCTGCC	0.567	NSCLC(71;908 1374 5429 20458 35642)		NA											23	49					1.10513e-12	1.89069e-12	0.002299	1	0
HMCN1	83872	broad.mit.edu	37	1	185939528	185939528	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:185939528G>A	uc001grq.1	+	15	2503	c.2274G>A	c.(2272-2274)AAG>AAA	p.K758K	HMCN1_uc001grr.1_Silent_p.K99K	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	758	Ig-like C2-type 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GACTTTTGAAGATTCAAGAAA	0.428			NA											56	163					0	0	0.00361	0	0
HMCN1	83872	broad.mit.edu	37	1	186064471	186064471	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:186064471C>G	uc001grq.1	+	68	10620	c.10391C>G	c.(10390-10392)GCT>GGT	p.A3464G		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3464	Ig-like C2-type 33.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGAACCCCAGCTCCCAGTATG	0.522			NA											20	34					0	0	0.007413	0	0
FAM5C	339479	broad.mit.edu	37	1	190203575	190203575	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:190203575G>T	uc001gse.1	-	5	883	c.651C>A	c.(649-651)TGC>TGA	p.C217*	FAM5C_uc010pot.1_Nonsense_Mutation_p.C115*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	217						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CATAGTTACTGCAGCCAAGAG	0.373			NA											11	59					0.00010058	0.000124382	0.001368	1	0
CFH	3075	broad.mit.edu	37	1	196711060	196711060	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:196711060G>A	uc001gtj.3	+	19	3252	c.3012G>A	c.(3010-3012)AAG>AAA	p.K1004K		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1004	Sushi 17.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGGGAGAGAAGAAGGATGTGT	0.368			NA											4	47					0	0	0.000248	0	0
CFHR3	10878	broad.mit.edu	37	1	196749016	196749016	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:196749016C>A	uc001gtl.2	+	3	430	c.343C>A	c.(343-345)CAT>AAT	p.H115N	CFHR3_uc001gtk.2_Missense_Mutation_p.H115N|CFHR3_uc010poy.1_Missense_Mutation_p.H115N|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	115	Sushi 2.					extracellular space					0						AGTTGCCTGCCATCCTGGCTA	0.428			NA											11	40					0.00829132	0.00946874	0.008291	1	0
F13B	2165	broad.mit.edu	37	1	197025021	197025021	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:197025021T>C	uc001gtt.1	-	8	1222	c.1178A>G	c.(1177-1179)AAT>AGT	p.N393S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	393					blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACAATTCTCATTATTTTCTAA	0.328			NA											9	27					0	0	0.004482	0	0
IGFN1	91156	broad.mit.edu	37	1	201196296	201196296	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:201196296G>T	uc001gwc.2	+	12	3325	c.2553G>T	c.(2551-2553)ACG>ACT	p.T851T	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CTGAGAACACGCTGGGCCAGG	0.637			NA											3	12					0.004672	0.00538583	0.004672	1	0
ATP2B4	493	broad.mit.edu	37	1	203680134	203680134	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:203680134G>T	uc001gzw.2	+	12	2813	c.1929G>T	c.(1927-1929)CGG>CGT	p.R643R	ATP2B4_uc001gzv.2_Silent_p.R643R|ATP2B4_uc009xaq.2_Silent_p.R643R	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	643	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TAGCTTACCGGGACTTCGATG	0.532			NA											6	40					1.6384e-10	2.6415e-10	0.001984	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204438211	204438211	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:204438211C>G	uc001haw.2	-	3	1199	c.720G>C	c.(718-720)TTG>TTC	p.L240F	PIK3C2B_uc010pqv.1_Missense_Mutation_p.L240F|PIK3C2B_uc001hax.1_Missense_Mutation_p.L240F|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	240	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AGGTCGATTTCAAGTTGAGCC	0.567			NA											31	262					0	0	0.002445	0	0
LRRN2	10446	broad.mit.edu	37	1	204589036	204589036	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:204589036A>T	uc001hbe.1	-	3	473	c.85T>A	c.(85-87)TGC>AGC	p.C29S	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.C29S|LRRN2_uc009xbf.1_Missense_Mutation_p.C29S|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	29	Extracellular (Potential).|LRRNT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGAGGGGGGCAGGGAACATGC	0.652			NA											9	26					0	0	0.008291	0	0
NFASC	23114	broad.mit.edu	37	1	204943892	204943892	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:204943892C>A	uc001hbj.2	+	14	1827	c.1499C>A	c.(1498-1500)ACC>AAC	p.T500N	NFASC_uc001hbh.2_Missense_Mutation_p.T500N|NFASC_uc010pqz.1_Missense_Mutation_p.T494N|NFASC_uc010pra.1_Missense_Mutation_p.T511N|NFASC_uc001hbi.2_Missense_Mutation_p.T511N|NFASC_uc010prb.1_Missense_Mutation_p.T511N|NFASC_uc010prc.1_Missense_Mutation_p.T67N|NFASC_uc001hbk.1_Missense_Mutation_p.T321N	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	500	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCATCTACACCTGTGTCGCC	0.522			NA											13	75					1.5842e-08	2.38251e-08	0.001855	1	0
RCOR3	55758	broad.mit.edu	37	1	211487016	211487016	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:211487016G>T	uc001hig.2	+	11	1563	c.1394G>T	c.(1393-1395)CGT>CTT	p.R465L	RCOR3_uc010psw.1_Missense_Mutation_p.R523L|RCOR3_uc001hif.2_3'UTR|RCOR3_uc009xcz.2_RNA	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	465	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		ATGCCACCCCGTCTAAACCCA	0.522			NA											5	68					0.000602214	0.000715729	0.000602	1	0
TATDN3	128387	broad.mit.edu	37	1	212988354	212988354	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:212988354G>T	uc001hjo.2	+	10	776	c.682_splice	c.e10-1	p.V228_splice	TATDN3_uc010ptj.1_Intron|TATDN3_uc010ptk.1_Splice_Site_p.V235_splice|TATDN3_uc001hjp.2_Splice_Site_p.V227_splice|TATDN3_uc010ptl.1_Splice_Site_p.V207_splice|TATDN3_uc010ptm.1_Splice_Site_p.V175_splice	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1							nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		TCTTGTTTCAGGTACGGAATG	0.413			NA											38	110					1.07637e-12	1.84618e-12	0.004878	1	0
PROX1	5629	broad.mit.edu	37	1	214184904	214184904	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:214184904G>T	uc001hkh.2	+	4	2146	c.1874G>T	c.(1873-1875)AGC>ATC	p.S625I		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	625	Prospero-type homeobox.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AAGTGGTTTAGCAATTTCCGT	0.378			NA											9	69					3.09899e-07	4.40883e-07	0.004482	1	0
USH2A	7399	broad.mit.edu	37	1	216243601	216243601	+	Missense_Mutation	SNP	C	C	A	rs149465057		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:216243601C>A	uc001hku.1	-	30	6278	c.5891G>T	c.(5890-5892)CGC>CTC	p.R1964L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1964	Extracellular (Potential).|Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTTAAGCTGCGGACTCTTGA	0.443			NA								HNSCC(13;0.011)			19	44					3.32936e-07	4.72157e-07	0.006122	1	0
USH2A	7399	broad.mit.edu	37	1	216405433	216405433	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:216405433G>T	uc001hku.1	-	14	3242	c.2855C>A	c.(2854-2856)TCA>TAA	p.S952*	USH2A_uc001hkv.2_Nonsense_Mutation_p.S952*	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	952	Extracellular (Potential).|Laminin EGF-like 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTATGGCATGAGCATGGCAG	0.393			NA								HNSCC(13;0.011)			18	63					6.49762e-13	1.1159e-12	0.006122	1	0
EPRS	2058	broad.mit.edu	37	1	220153525	220153525	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:220153525C>A	uc001hly.1	-	26	3883	c.3613G>T	c.(3613-3615)GTT>TTT	p.V1205F		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1205	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	CCTTTAACAACAGGAATTGCC	0.358			NA											24	62					2.98393e-07	4.26775e-07	0.00278	1	0
EPRS	2058	broad.mit.edu	37	1	220160553	220160553	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:220160553G>C	uc001hly.1	-	20	3239	c.2969C>G	c.(2968-2970)TCT>TGT	p.S990C	EPRS_uc010puf.1_Missense_Mutation_p.S741C|EPRS_uc001hlz.1_Missense_Mutation_p.S997C	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	990	Charged.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TTGGTTTTTAGAAGGGTCTTT	0.423			NA											12	96					0	0	0.000978	0	0
GALNT2	2590	broad.mit.edu	37	1	230372467	230372467	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:230372467A>T	uc010pwa.1	+	6	675	c.603A>T	c.(601-603)CGA>CGT	p.R201R	GALNT2_uc010pvy.1_Silent_p.R163R|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	201	Lumenal (Potential).|Catalytic subdomain A.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ATGATCGACGAGAAGGTAAGA	0.398			NA											6	33					0	0	0.001984	0	0
RYR2	6262	broad.mit.edu	37	1	237540734	237540734	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:237540734T>A	uc001hyl.1	+	8	695	c.575T>A	c.(574-576)TTG>TAG	p.L192*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	192	Cytoplasmic (By similarity).|MIR 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAAGGTACTTGGTAAGTGTG	0.383			NA											5	24					0	0	0.001168	0	0
RYR2	6262	broad.mit.edu	37	1	237753237	237753238	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:237753237_237753238CC>AA	uc001hyl.1	+	30	3863_3864	c.3743_3744CC>AA	c.(3742-3744)ACC>AAA	p.T1248K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1248	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGGATATTACCATGTGGCTGA	0.386			NA											6	33					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237791243	237791243	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:237791243C>A	uc001hyl.1	+	41	6423	c.6303C>A	c.(6301-6303)GCC>GCA	p.A2101A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2101	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGTTCGGGCCCTGCCAAAGA	0.562			NA											9	27					2.74318e-10	4.40681e-10	0.006214	1	0
RYR2	6262	broad.mit.edu	37	1	237794803	237794803	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:237794803G>T	uc001hyl.1	+	42	6637	c.6517G>T	c.(6517-6519)GAG>TAG	p.E2173*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2173	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACTGTGATGGAGGTCATGGT	0.438			NA											5	23					1.23904e-05	1.62503e-05	0.000602	1	0
ZP4	57829	broad.mit.edu	37	1	238048716	238048716	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:238048716G>A	uc001hym.2	-	8	1135	c.1135C>T	c.(1135-1137)CCA>TCA	p.P379S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	379	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGCCACTGTGGCTGACTCAGG	0.537	NSCLC(166;160 2029 11600 18754 19936)		NA											11	55					0	0	0.000978	0	0
CHRM3	1131	broad.mit.edu	37	1	240072433	240072433	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:240072433G>T	uc001hyp.2	+	5	2461	c.1682G>T	c.(1681-1683)TGC>TTC	p.C561F		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	561	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CTGCTGCTGTGCCAGTGTGAC	0.517			NA											14	38					0.00185496	0.00218336	0.001855	1	0
FMN2	56776	broad.mit.edu	37	1	240256545	240256545	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:240256545G>A	uc010pyd.1	+	1	1361	c.1136G>A	c.(1135-1137)GGG>GAG	p.G379E	FMN2_uc010pye.1_Missense_Mutation_p.G379E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	379					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGAGGCTGGGGGAAGAGCCG	0.726			NA											4	9					0	0	0.000248	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242161836	242161836	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:242161836G>A	uc001hzk.2	-	3	276	c.201C>T	c.(199-201)ACC>ACT	p.T67T		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	67					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGAGGAACTGGGTCATGGTCA	0.622			NA									OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	44					0	0	0.004482	0	0
NLRP3	114548	broad.mit.edu	37	1	247587966	247587966	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:247587966C>A	uc001icr.2	+	5	1359	c.1221C>A	c.(1219-1221)ACC>ACA	p.T407T	NLRP3_uc001ics.2_Silent_p.T407T|NLRP3_uc001icu.2_Silent_p.T407T|NLRP3_uc001icw.2_Silent_p.T407T|NLRP3_uc001icv.2_Silent_p.T407T|NLRP3_uc010pyw.1_Silent_p.T405T|NLRP3_uc001ict.1_Silent_p.T405T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	407	NACHT.		T -> P (in CINCA).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTCTTCACCATGTGCTTCA	0.547			NA											10	42					7.48243e-07	1.04676e-06	0.006214	1	0
NLRP3	114548	broad.mit.edu	37	1	247587984	247587984	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:247587984G>T	uc001icr.2	+	5	1377	c.1239G>T	c.(1237-1239)CTG>CTT	p.L413L	NLRP3_uc001ics.2_Silent_p.L413L|NLRP3_uc001icu.2_Silent_p.L413L|NLRP3_uc001icw.2_Silent_p.L413L|NLRP3_uc001icv.2_Silent_p.L413L|NLRP3_uc010pyw.1_Silent_p.L411L|NLRP3_uc001ict.1_Silent_p.L411L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	413	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCATCCCCCTGGTCTGCTGGA	0.547			NA											10	37					1.76689e-08	2.64247e-08	0.006214	1	0
OR2T12	127064	broad.mit.edu	37	1	248458172	248458172	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:248458172C>A	uc010pzj.1	-	1	709	c.709G>T	c.(709-711)GCC>TCC	p.A237S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GAGCAGGTGGCAAAGGCCTTC	0.517			NA											16	80					3.41278e-10	5.4499e-10	0.00499	1	0
OR2T2	401992	broad.mit.edu	37	1	248616358	248616358	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:248616358T>A	uc001iek.1	+	1	260	c.260T>A	c.(259-261)CTG>CAG	p.L87Q		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGGACCTCCTGTCCAAGGAC	0.537			NA											9	204					0	0	0.004007	0	0
OR2T27	403239	broad.mit.edu	37	1	248813817	248813817	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:248813817G>T	uc010pzo.1	-	1	369	c.369C>A	c.(367-369)TAC>TAA	p.Y123*		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGATGGCTACGTAGCGATCAT	0.542			NA											20	47					3.99206e-14	7.06368e-14	0.007413	1	0
C10orf18	54906	broad.mit.edu	37	10	5791571	5791571	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:5791571C>G	uc001iij.2	+	15	6812	c.6187C>G	c.(6187-6189)CTG>GTG	p.L2063V	C10orf18_uc001iik.2_Missense_Mutation_p.L907V	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2063										ovary(1)|central_nervous_system(1)	2						AGCCAGCAGTCTGGACAGCTC	0.493			NA											10	71					0	0	0.006214	0	0
SFMBT2	57713	broad.mit.edu	37	10	7214086	7214086	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:7214086T>C	uc009xio.1	-	19	2277	c.2186A>G	c.(2185-2187)GAT>GGT	p.D729G	SFMBT2_uc001ijn.1_Missense_Mutation_p.D729G|SFMBT2_uc010qay.1_Missense_Mutation_p.D564G	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	729					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GGCGGTGTCATCGTCCATGGC	0.692			NA											3	14					0	0	0.004672	0	0
ITIH2	3698	broad.mit.edu	37	10	7755193	7755193	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:7755193G>T	uc001ijs.2	+	5	574	c.412G>T	c.(412-414)GGC>TGC	p.G138C		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	138	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GAAAACTGTGGGCCGAGCTCT	0.483			NA											11	74					0.00185496	0.00218336	0.001855	1	0
ITIH2	3698	broad.mit.edu	37	10	7771952	7771952	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:7771952G>T	uc001ijs.2	+	12	1479	c.1317G>T	c.(1315-1317)AAG>AAT	p.K439N		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	439	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AAAACGTTAAGGAGAACATCC	0.358			NA											15	25					0.000422831	0.000509294	0.004007	1	0
TAF3	83860	broad.mit.edu	37	10	7866463	7866463	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:7866463G>T	uc010qbd.1	+	2	349	c.349G>T	c.(349-351)GCA>TCA	p.A117S		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	117					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AAGTAAAGATGCAGAGGAAAG	0.388			NA											28	55					0.000117367	0.000145008	0.005443	1	0
DHTKD1	55526	broad.mit.edu	37	10	12159749	12159749	+	Silent	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:12159749A>C	uc001ild.3	+	14	2496	c.2397A>C	c.(2395-2397)CCA>CCC	p.P799P		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	799					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CTGTGGATCCAAAAAAGTAAG	0.413			NA											6	80					0	0	0.001168	0	0
PRPF18	8559	broad.mit.edu	37	10	13672285	13672285	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:13672285G>A	uc001imp.2	+	10	1122	c.974G>A	c.(973-975)TGC>TAC	p.C325Y	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	325					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						ATGACCATTTGCCAGAAACAC	0.299			NA											12	68					0	0	0.003163	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256342	15256342	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:15256342G>C	uc001iob.2	-	8	1252	c.1245C>G	c.(1243-1245)CTC>CTG	p.L415L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	415	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AGGAGAGCTTGAGCATGGGGG	0.582			NA											3	75					0	0	0.004672	0	0
FAM171A1	221061	broad.mit.edu	37	10	15263042	15263042	+	Missense_Mutation	SNP	C	C	A	rs146109085		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:15263042C>A	uc001iob.2	-	6	779	c.772G>T	c.(772-774)GGT>TGT	p.G258C		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	258	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AGACCCAGACCGCTCTTCAGC	0.537			NA											5	59					1.23904e-05	1.62503e-05	0.000602	1	0
ITGA8	8516	broad.mit.edu	37	10	15760795	15760795	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:15760795G>A	uc001ioc.1	-	2	313	c.313C>T	c.(313-315)CAG>TAG	p.Q105*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.Q105*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	105	Extracellular (Potential).|FG-GAP 1.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TGCCTGCACTGCGCAGACCCC	0.597			NA											7	78					0	0	0.00308	0	0
MRC1	4360	broad.mit.edu	37	10	17949705	17949705	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:17949705A>G	uc001ipk.2	+	28	4172	c.4069A>G	c.(4069-4071)AGA>GGA	p.R1357G		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	1357	Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						TATTTGTAAAAGACCAAAAAG	0.363	GBM(115;1153 1594 28187 28781 35884)		NA											49	111					0	0	0.00361	0	0
MLLT10	8028	broad.mit.edu	37	10	22002777	22002777	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:22002777C>T	uc001iqs.2	+	15	2172	c.1824C>T	c.(1822-1824)TCC>TCT	p.S608S	MLLT10_uc001iqt.2_Silent_p.S592S|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Silent_p.S592S|MLLT10_uc001ira.2_Silent_p.S49S|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	608	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						CTCCTGTCTCCAGCTCTCACT	0.453			NA	T	MLL|PICALM|CDK6	AL								13	65					0	0	0.004007	0	0
GPR158	57512	broad.mit.edu	37	10	25883274	25883274	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:25883274C>A	uc001isj.2	+	9	2006	c.1946C>A	c.(1945-1947)GCA>GAA	p.A649E	GPR158_uc001isk.2_Missense_Mutation_p.A24E	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	649	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CTGTATTTTGCACATACTCAT	0.318			NA											23	59					1.55469e-16	2.86413e-16	0.00333	1	0
ARMC4	55130	broad.mit.edu	37	10	28149741	28149741	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:28149741G>C	uc009xky.2	-	19	2932	c.2834C>G	c.(2833-2835)GCT>GGT	p.A945G	ARMC4_uc010qds.1_Missense_Mutation_p.A470G|ARMC4_uc010qdt.1_Missense_Mutation_p.A637G|ARMC4_uc001itz.2_Missense_Mutation_p.A945G	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	945	ARM 8.						binding			ovary(4)|skin(2)	6						ACGTGAAATAGCTTCTGCTAG	0.433			NA											10	48					0	0	0.006214	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336711	30336711	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:30336711G>T	uc001iux.2	-	1	90	c.31C>A	c.(31-33)CAT>AAT	p.H11N	KIAA1462_uc001iuy.2_Missense_Mutation_p.H11N|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Missense_Mutation_p.H11N	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	11										ovary(4)	4						TTGTATCCATGAGAGATCAGG	0.592			NA											13	89					0.000151284	0.00018657	0.001855	1	0
FAM21C	253725	broad.mit.edu	37	10	46264993	46264993	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:46264993G>T	uc001jcu.2	+	20	2065	c.1966G>T	c.(1966-1968)GCC>TCC	p.A656S	FAM21C_uc001jcs.1_Missense_Mutation_p.A599S|FAM21C_uc001jct.2_Missense_Mutation_p.A654S|FAM21C_uc010qfi.1_Missense_Mutation_p.A632S|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'UTR	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	656										ovary(1)	1						GAGCCAGGAGGCCAAGGCTGT	0.493			NA											41	100					1.57019e-19	2.99541e-19	0.007835	1	0
CSTF2T	23283	broad.mit.edu	37	10	53458533	53458533	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:53458533C>G	uc001jjp.2	-	1	823	c.777G>C	c.(775-777)CAG>CAC	p.Q259H	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	259					mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GAATTCCACCCTGGATAGGAG	0.547			NA											4	34					0	0	0.000248	0	0
PCDH15	65217	broad.mit.edu	37	10	55566610	55566610	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:55566610A>T	uc010qhq.1	-	36	5173	c.4778T>A	c.(4777-4779)CTG>CAG	p.L1593Q	PCDH15_uc010qhr.1_Missense_Mutation_p.L1588Q	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TAATGTGTTCAGAGGTACATT	0.468			NA								HNSCC(58;0.16)			12	235					0	0	0.001855	0	0
FAM13C	220965	broad.mit.edu	37	10	61083748	61083748	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:61083748C>A	uc001jkn.2	-	5	577	c.443G>T	c.(442-444)AGA>ATA	p.R148I	FAM13C_uc001jko.2_Missense_Mutation_p.R148I|FAM13C_uc010qid.1_Missense_Mutation_p.R65I|FAM13C_uc010qie.1_Missense_Mutation_p.R65I|FAM13C_uc010qif.1_Missense_Mutation_p.R170I|FAM13C_uc001jkp.2_Missense_Mutation_p.R65I	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	148										ovary(2)	2						AAGGGCCCACCTTGGTTGAAG	0.498			NA											9	134					2.17888e-05	2.81911e-05	0.006214	1	0
HKDC1	80201	broad.mit.edu	37	10	71000429	71000429	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:71000429G>T	uc001jpf.3	+	6	746	c.613G>T	c.(613-615)GCC>TCC	p.A205S	HKDC1_uc010qje.1_Missense_Mutation_p.A68S	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	205					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						GGACATCCTGGCCCTGGTCAA	0.572			NA											18	34					1.9806e-07	2.84182e-07	0.002299	1	0
COL13A1	1305	broad.mit.edu	37	10	71678040	71678040	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:71678040G>T	uc001jpr.1	+	18	1533	c.997_splice	c.e18-1	p.G333_splice	COL13A1_uc001jqj.1_Splice_Site_p.G333_splice|COL13A1_uc001jps.1_Splice_Site_p.G304_splice|COL13A1_uc001jpt.1_Splice_Site_p.G292_splice|COL13A1_uc001jpu.1_Splice_Site_p.G314_splice|COL13A1_uc001jpv.1_Splice_Site_p.G333_splice|COL13A1_uc001jpx.1_Splice_Site_p.G311_splice|COL13A1_uc001jpw.1_Splice_Site_p.G280_splice|COL13A1_uc001jpy.1_Splice_Site_p.G271_splice|COL13A1_uc001jpz.1_Splice_Site_p.G276_splice|COL13A1_uc001jqa.1_Splice_Site_p.G273_splice|COL13A1_uc001jqc.1_Splice_Site_p.G333_splice|COL13A1_uc001jqb.1_Splice_Site_p.G282_splice|COL13A1_uc001jql.2_Splice_Site_p.G333_splice|COL13A1_uc001jqd.1_Splice_Site_p.G321_splice|COL13A1_uc001jqe.1_Splice_Site_p.G316_splice|COL13A1_uc001jqf.1_Splice_Site_p.G314_splice|COL13A1_uc001jqg.1_Splice_Site_p.G311_splice|COL13A1_uc001jqh.1_Splice_Site_p.G333_splice|COL13A1_uc001jqi.1_Splice_Site_p.G333_splice|COL13A1_uc010qjf.1_Splice_Site_p.G123_splice|COL13A1_uc001jqk.1_Splice_Site_p.G171_splice	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1						cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	CTCTCTGCCAGGGGGCGCCCG	0.602			NA											13	30					7.03913e-09	1.07427e-08	0.001368	1	0
CDHR1	92211	broad.mit.edu	37	10	85974034	85974034	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:85974034C>G	uc001kcv.2	+	17	2237	c.2237C>G	c.(2236-2238)CCT>CGT	p.P746R	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.P450R|CDHR1_uc001kcx.2_Missense_Mutation_p.P60R	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	746	Cytoplasmic (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CGGCCCAGCCCTGCGCCCCGC	0.582			NA											20	34					0	0	0.001216	0	0
LIPF	8513	broad.mit.edu	37	10	90427435	90427435	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:90427435G>T	uc001kfg.1	+	3	381	c.215G>T	c.(214-216)GGG>GTG	p.G72V	LIPF_uc009xtk.2_Missense_Mutation_p.G72V|LIPF_uc001kfh.1_Missense_Mutation_p.G82V|LIPF_uc010qmt.1_Missense_Mutation_p.G82V|LIPF_uc010qmu.1_Missense_Mutation_p.G72V	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	72					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AAAAATTCAGGGAATACAGGT	0.204			NA											25	87					1.17739e-12	2.00665e-12	0.005443	1	0
SLC16A12	387700	broad.mit.edu	37	10	91198926	91198926	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:91198926G>C	uc001kgm.2	-	6	764	c.373C>G	c.(373-375)CTT>GTT	p.L125V	SLC16A12_uc001kgl.2_5'Flank	NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	125	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						GAGTAACAAAGTGCAAATCCA	0.418			NA											3	58					0	0	0.004672	0	0
IDE	3416	broad.mit.edu	37	10	94228661	94228661	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:94228661C>A	uc001kia.2	-	19	2371	c.2295G>T	c.(2293-2295)CGG>CGT	p.R765R	IDE_uc010qnp.1_Silent_p.R210R|IDE_uc001khz.2_Silent_p.R210R	NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	765					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTCTCTATACCGAACCAGCT	0.428			NA											3	33					2.56e-06	3.49044e-06	0.000248	1	0
ABCC2	1244	broad.mit.edu	37	10	101560265	101560265	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:101560265G>T	uc001kqf.2	+	9	1293	c.1154G>T	c.(1153-1155)TGC>TTC	p.C385F		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	385	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCCAACTGTGCTTCAAGCTG	0.433			NA											9	146					3.09899e-07	4.40883e-07	0.004482	1	0
SORCS1	114815	broad.mit.edu	37	10	108923926	108923926	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:108923926C>A	uc001kym.2	-	1	367	c.359G>T	c.(358-360)CGG>CTG	p.R120L	SORCS1_uc001kyl.2_Missense_Mutation_p.R120L|SORCS1_uc009xxs.2_Missense_Mutation_p.R120L|SORCS1_uc001kyn.1_Missense_Mutation_p.R120L|SORCS1_uc001kyo.2_Missense_Mutation_p.R120L	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	120	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCCCTCTCCCCGTTCTGCCTT	0.701			NA											8	28					0.000157383	0.000191976	0.00308	1	0
NRAP	4892	broad.mit.edu	37	10	115364431	115364431	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:115364431G>T	uc001laj.2	-	35	4328	c.4164C>A	c.(4162-4164)TTC>TTA	p.F1388L	NRAP_uc009xyb.2_Missense_Mutation_p.F177L|NRAP_uc001lak.2_Missense_Mutation_p.F1353L|NRAP_uc001lal.3_Missense_Mutation_p.F1388L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1388	Nebulin 36.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GCAGTGCTGTGAACTTGTGAT	0.597			NA											15	41					1.49906e-05	1.9584e-05	0.00245	1	0
ATRNL1	26033	broad.mit.edu	37	10	117024743	117024743	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:117024743A>G	uc001lcg.2	+	11	2147	c.1761A>G	c.(1759-1761)GTA>GTG	p.V587V		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	587	Kelch 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACTCTGCAGTAGTCATTAACG	0.299			NA											7	125					0	0	0.001984	0	0
C10orf46	143384	broad.mit.edu	37	10	120450853	120450853	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:120450853C>A	uc001lds.1	-	7	1433	c.949G>T	c.(949-951)GTG>TTG	p.V317L	C10orf46_uc010qst.1_RNA	NM_153810	NP_722517	Q86Y37	CJ046_HUMAN	chromosome 10 open reading frame 46	317					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)		TCAGATTCCACCGCCGGAGGG	0.358			NA											46	132					1.47857e-17	2.75795e-17	0.00361	1	0
MKI67	4288	broad.mit.edu	37	10	129904768	129904768	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:129904768C>A	uc001lke.2	-	13	5531	c.5336G>T	c.(5335-5337)GGC>GTC	p.G1779V	MKI67_uc001lkf.2_Missense_Mutation_p.G1419V|MKI67_uc009yav.1_Missense_Mutation_p.G1354V|MKI67_uc009yaw.1_Missense_Mutation_p.G929V	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1779	7.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CATGGCTTTGCCTGCTGATGG	0.473			NA											50	96					1.30916e-28	2.59706e-28	0.00361	1	0
BNIP3	664	broad.mit.edu	37	10	133786581	133786581	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:133786581G>C	uc001lkv.1	-	3	365	c.239C>G	c.(238-240)TCT>TGT	p.S80C	BNIP3_uc001lku.1_5'Flank|BNIP3_uc010qut.1_Missense_Mutation_p.S80C	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	80					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ATCTGTTTCAGAAGCTCTGTT	0.423			NA											6	171					0	0	0.001984	0	0
MTG1	92170	broad.mit.edu	37	10	135213068	135213068	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:135213068C>G	uc001lnd.2	+	6	560	c.456C>G	c.(454-456)CCC>CCG	p.P152P	MTG1_uc010qve.1_Intron	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	152						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		TTGGGGTCCCCAACGTGGGCA	0.622			NA											15	50					0	0	0.003163	0	0
MUC2	4583	broad.mit.edu	37	11	1087978	1087978	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:1087978C>T	uc001lsx.1	+	25	3480	c.3453C>T	c.(3451-3453)ATC>ATT	p.I1151I		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1151						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TCAACGGCATCCACTCCAACA	0.627			NA											3	12					0	0	0.000248	0	0
MUC5B	727897	broad.mit.edu	37	11	1272524	1272524	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:1272524C>G	uc009ycr.1	+	52	15506	c.15380C>G	c.(15379-15381)TCC>TGC	p.S5127C	MUC5B_uc001ltb.2_Missense_Mutation_p.S4808C	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACCAATTCCACGGCCACA	0.602			NA											10	92					0	0	0.000978	0	0
TSPAN32	10077	broad.mit.edu	37	11	2337814	2337814	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:2337814C>T	uc001lvy.1	+	8	773	c.636C>T	c.(634-636)GCC>GCT	p.A212A	TSPAN32_uc010qxk.1_3'UTR|TSPAN32_uc009ydl.1_Intron|TSPAN32_uc001lvz.1_Silent_p.A182A|TSPAN32_uc001lwb.1_Silent_p.A182A|TSPAN32_uc001lwc.1_Silent_p.A157A|TSPAN32_uc001lwd.1_Silent_p.A144A	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	212	Helical; (Potential).				cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AGGTGTCCGCCTTGCTCTTCA	0.677			NA											12	37					0	0	0.000978	0	0
RHOG	391	broad.mit.edu	37	11	3849149	3849149	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:3849149G>C	uc001lyu.2	-	2	378	c.220C>G	c.(220-222)CAG>GAG	p.Q74E		NM_001665	NP_001656	P84095	RHOG_HUMAN	ras homolog gene family, member G precursor	74					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		ACGTTGGTCTGAGGGTAGGAG	0.602			NA											4	59					0	0	0.001984	0	0
OR51G1	79324	broad.mit.edu	37	11	4945465	4945465	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:4945465G>A	uc010qyr.1	-	1	105	c.105C>T	c.(103-105)TTC>TTT	p.F35F		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAGGTAGATGAAGCAGAAGG	0.478			NA											4	53					0	0	0.000602	0	0
OR51L1	119682	broad.mit.edu	37	11	5020306	5020306	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5020306C>A	uc010qyu.1	+	1	94	c.94C>A	c.(94-96)CTC>ATC	p.L32I		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTCTCCATCCTCTTCTGTCT	0.428			NA											51	137					1.33152e-38	2.68101e-38	0.00361	1	0
OR52A4	390053	broad.mit.edu	37	11	5142343	5142343	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5142343G>T	uc001lzz.1	-	1	466	c.466C>A	c.(466-468)CCT>ACT	p.P156T		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGAATGGCAGGCCGCAATGTC	0.463			NA											15	50					1.37285e-15	2.4715e-15	0.004007	1	0
OR52A5	390054	broad.mit.edu	37	11	5152990	5152990	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5152990A>G	uc010qyx.1	-	1	883	c.883T>C	c.(883-885)TAT>CAT	p.Y295H		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTCACTCCATAGACAATAGGG	0.373			NA											15	40					0	0	0.004007	0	0
OR51I1	390063	broad.mit.edu	37	11	5462541	5462541	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5462541G>T	uc010qze.1	-	1	204	c.204C>A	c.(202-204)CTC>CTA	p.L68L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTGAGAGCGAGCATAGAGA	0.468			NA											11	53					1.58986e-06	2.20122e-06	0.008291	1	0
OR56A3	390083	broad.mit.edu	37	11	5969313	5969313	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5969313G>T	uc010qzt.1	+	1	737	c.737G>T	c.(736-738)GGC>GTC	p.G246V		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCACATGTGGCTCCCACTTC	0.517			NA											49	148					6.14515e-18	1.15587e-17	0.00361	1	0
OR56A5	390084	broad.mit.edu	37	11	5989001	5989001	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:5989001C>A	uc010qzu.1	-	1	724	c.724G>T	c.(724-726)GGT>TGT	p.G242C		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	242	Cytoplasmic (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						CCACAAGTACCTAGAGCTTTG	0.473			NA											7	17					0.00198382	0.00231877	0.001984	1	0
OR56B4	196335	broad.mit.edu	37	11	6129206	6129206	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:6129206C>A	uc010qzx.1	+	1	198	c.198C>A	c.(196-198)TAC>TAA	p.Y66*		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AACCCATGTACCATTTGCTGG	0.517			NA											18	29					3.52763e-06	4.77101e-06	0.00499	1	0
OR56B4	196335	broad.mit.edu	37	11	6129645	6129645	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:6129645G>C	uc010qzx.1	+	1	637	c.637G>C	c.(637-639)GTT>CTT	p.V213L		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGGTCTTGGTTGGGAGTGA	0.478			NA											40	151					0	0	0.006999	0	0
CCKBR	887	broad.mit.edu	37	11	6292011	6292011	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:6292011C>A	uc001mcp.2	+	4	982	c.789C>A	c.(787-789)GTC>GTA	p.V263V	CCKBR_uc001mcq.2_Silent_p.V191V|CCKBR_uc001mcr.2_Silent_p.V263V|CCKBR_uc001mcs.2_Silent_p.V263V|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	263	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	AAAGCAGGGTCCGAAACCAAG	0.642			NA											17	35					6.94344e-10	1.10095e-09	0.006122	1	0
DCHS1	8642	broad.mit.edu	37	11	6648657	6648657	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:6648657C>A	uc001mem.1	-	14	6023	c.5613G>T	c.(5611-5613)GGG>GGT	p.G1871G		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1871	Cadherin 18.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGCAGGGTCCCTGCAGGCA	0.607			NA											3	8					6.4e-05	8.03467e-05	0.004672	1	0
OR10A6	390093	broad.mit.edu	37	11	7950041	7950041	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:7950041C>A	uc010rbh.1	-	1	169	c.169G>T	c.(169-171)GTT>TTT	p.V57F		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TACATGGGAACGTGGAGGCTC	0.468			NA											37	82					6.5261e-18	1.22581e-17	0.00874	1	0
TUB	7275	broad.mit.edu	37	11	8123070	8123070	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:8123070G>T	uc001mga.2	+	12	1574	c.1425G>T	c.(1423-1425)GAG>GAT	p.E475D	TUB_uc010rbk.1_Missense_Mutation_p.E481D|TUB_uc001mfy.2_Missense_Mutation_p.E530D	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	475					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		GGGTAGCAGAGGATGTGTTCA	0.572			NA											24	90					4.72057e-08	6.96674e-08	0.003954	1	0
NRIP3	56675	broad.mit.edu	37	11	9009769	9009769	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:9009769C>G	uc001mhg.2	-	2	349	c.235G>C	c.(235-237)GGT>CGT	p.G79R	NRIP3_uc010rbu.1_Missense_Mutation_p.G79R	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	79					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		ACACGGGGACCGCTTCGGAGC	0.493			NA											18	58					0	0	0.006122	0	0
USH1C	10083	broad.mit.edu	37	11	17544392	17544392	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:17544392G>T	uc001mnf.2	-	12	1067	c.958C>A	c.(958-960)CAG>AAG	p.Q320K	USH1C_uc001mne.2_Missense_Mutation_p.Q320K|USH1C_uc009yhb.2_Missense_Mutation_p.Q301K|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.Q284K	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	320	Potential.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						AGCCGCTTCTGCATGAGAAGC	0.657			NA											3	15					0.004672	0.00538583	0.004672	1	0
IGSF22	283284	broad.mit.edu	37	11	18738369	18738369	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:18738369G>T	uc009yht.2	-	10	1342	c.1152C>A	c.(1150-1152)CAC>CAA	p.H384Q	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	384										ovary(4)|large_intestine(2)|kidney(1)	7						TCTTAAGCGTGTGCGTCAGAC	0.517			NA											43	129					2.35958e-20	4.55305e-20	0.002222	1	0
NAV2	89797	broad.mit.edu	37	11	20119157	20119157	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:20119157T>C	uc001mpr.3	+	31	6417	c.6056T>C	c.(6055-6057)CTA>CCA	p.L2019P	NAV2_uc001mpp.2_Missense_Mutation_p.L1952P|NAV2_uc009yhx.2_Missense_Mutation_p.L1080P|NAV2_uc009yhz.2_Missense_Mutation_p.L661P|NAV2_uc001mpu.2_Missense_Mutation_p.L454P	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2075				L -> V (in Ref. 7; BAB85038).		nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GTGAGTCAGCTAGGGCTGAAT	0.448			NA											20	55					0	0	0.001216	0	0
DBX1	120237	broad.mit.edu	37	11	20178115	20178115	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:20178115T>C	uc001mpw.1	-	4	794	c.794A>G	c.(793-795)AAA>AGA	p.K265R		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	226	Homeobox.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAACCAGATTTTCACCTGGAA	0.647			NA											8	72					0	0	0.00308	0	0
PRMT3	10196	broad.mit.edu	37	11	20429456	20429456	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:20429456G>T	uc001mqb.2	+	9	989	c.772_splice	c.e9-1	p.V258_splice	PRMT3_uc001mqc.2_Splice_Site_p.V181_splice|PRMT3_uc010rdn.1_Splice_Site_p.V196_splice	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1								zinc ion binding				0						AATTACCCTAGGTAGTTTTGG	0.343			NA											28	63					1.04121e-07	1.515e-07	0.005443	1	0
C11orf41	25758	broad.mit.edu	37	11	33572767	33572767	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:33572767G>A	uc001mup.3	+	4	2934	c.2810G>A	c.(2809-2811)TGG>TAG	p.W937*	C11orf41_uc001mun.1_Nonsense_Mutation_p.W937*	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	931						integral to membrane				ovary(2)	2						GCCTCCCCATGGAATCCCCAG	0.527			NA											4	62					0	0	0.000248	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136437	40136437	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:40136437G>A	uc001mxa.1	-	2	3370	c.1406C>T	c.(1405-1407)GCA>GTA	p.A469V	LRRC4C_uc001mxc.1_Missense_Mutation_p.A465V|LRRC4C_uc001mxd.1_Missense_Mutation_p.A465V|LRRC4C_uc001mxb.1_Missense_Mutation_p.A465V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	469					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGTGGTCCGTGCCTCATCCTG	0.522			NA											19	48					0	0	0.001216	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136889	40136889	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:40136889G>T	uc001mxa.1	-	2	2918	c.954C>A	c.(952-954)GAC>GAA	p.D318E	LRRC4C_uc001mxc.1_Missense_Mutation_p.D314E|LRRC4C_uc001mxd.1_Missense_Mutation_p.D314E|LRRC4C_uc001mxb.1_Missense_Mutation_p.D314E	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	318	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGGGGGCCATGTCTTTTATCC	0.488			NA											16	33					0.000308642	0.000372422	0.003163	1	0
OR4X2	119764	broad.mit.edu	37	11	48267425	48267425	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:48267425T>C	uc001ngs.1	+	1	770	c.770T>C	c.(769-771)CTG>CCG	p.L257P		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	257	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTACCACTCTGCCCATAGAC	0.522			NA											8	37					0	0	0.004482	0	0
OR4C3	256144	broad.mit.edu	37	11	48347249	48347249	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:48347249C>A	uc010rhv.1	+	1	757	c.757C>A	c.(757-759)CAC>AAC	p.H253N		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTGAGGTCCCACAGTGCAGA	0.498			NA											9	97					0.00448238	0.00518058	0.004482	1	0
FOLH1	2346	broad.mit.edu	37	11	49208318	49208318	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:49208318C>A	uc001ngy.2	-	5	778	c.517G>T	c.(517-519)GAT>TAT	p.D173Y	FOLH1_uc001ngz.2_Missense_Mutation_p.D173Y|FOLH1_uc009yly.2_Missense_Mutation_p.D158Y|FOLH1_uc009ylz.2_Missense_Mutation_p.D158Y|FOLH1_uc009yma.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	173	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TACACTAGATCGCCCTGTTGA	0.393			NA											16	71					4.7546e-09	7.32274e-09	0.004007	1	0
OR4A16	81327	broad.mit.edu	37	11	55111564	55111564	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:55111564G>T	uc010rie.1	+	1	888	c.888G>T	c.(886-888)ATG>ATT	p.M296I		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						AAAATGCTATGAAAAATCTCT	0.313			NA											16	42					8.60227e-14	1.51018e-13	0.004007	1	0
OR4A15	81328	broad.mit.edu	37	11	55135452	55135452	+	Missense_Mutation	SNP	G	G	T	rs149233751		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:55135452G>T	uc010rif.1	+	1	93	c.93G>T	c.(91-93)ATG>ATT	p.M31I		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	31	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M31I(1)		ovary(1)|skin(1)	2						AAGAACACATGAAAAATAAGA	0.388			NA											8	35					0.00307968	0.00357786	0.00308	1	0
OR5D13	390142	broad.mit.edu	37	11	55541121	55541121	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:55541121T>A	uc010ril.1	+	1	208	c.208T>A	c.(208-210)TTG>ATG	p.L70M		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TCACTTGTCCTTGACAGACTT	0.398			NA											18	88					0	0	0.007413	0	0
OR5L1	219437	broad.mit.edu	37	11	55579578	55579578	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:55579578G>C	uc001nhw.1	+	1	636	c.636G>C	c.(634-636)ATG>ATC	p.M212I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TTACCATCATGATCATCCTCA	0.502			NA											30	108					0	0	0.007291	0	0
OR8K1	390157	broad.mit.edu	37	11	56114262	56114262	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:56114262C>A	uc010rjg.1	+	1	748	c.748C>A	c.(748-750)CAT>AAT	p.H250N		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CTGTAGCTCTCATCTGACAGT	0.408			NA								HNSCC(65;0.19)			16	48					6.31663e-08	9.24099e-08	0.003163	1	0
OR5M3	219482	broad.mit.edu	37	11	56237537	56237537	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:56237537G>T	uc010rjk.1	-	1	437	c.437C>A	c.(436-438)CCT>CAT	p.P146H		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATAAATGTAAGGGAAAGTAAT	0.413			NA											26	91					3.08376e-08	4.57624e-08	0.00333	1	0
OR9G9	504191	broad.mit.edu	37	11	56468604	56468604	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:56468604C>G	uc010rjn.1	+	1	741	c.741C>G	c.(739-741)GTC>GTG	p.V247V		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGACCTCTGTCACTTTATACT	0.453			NA											21	271					0	0	0.001523	0	0
CTNND1	1500	broad.mit.edu	37	11	57569438	57569438	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:57569438A>G	uc001nmc.3	+	7	1761	c.1190A>G	c.(1189-1191)AAT>AGT	p.N397S	CTNND1_uc001nlh.1_Missense_Mutation_p.N397S|CTNND1_uc001nlu.3_Missense_Mutation_p.N296S|CTNND1_uc001nlt.3_Missense_Mutation_p.N296S|CTNND1_uc001nls.3_Missense_Mutation_p.N296S|CTNND1_uc001nlw.3_Missense_Mutation_p.N296S|CTNND1_uc001nmf.3_Missense_Mutation_p.N397S|CTNND1_uc001nmd.3_Missense_Mutation_p.N343S|CTNND1_uc001nlk.3_Missense_Mutation_p.N343S|CTNND1_uc001nme.3_Missense_Mutation_p.N397S|CTNND1_uc001nll.3_Missense_Mutation_p.N343S|CTNND1_uc001nmg.3_Missense_Mutation_p.N343S|CTNND1_uc001nlj.3_Missense_Mutation_p.N343S|CTNND1_uc001nlr.3_Missense_Mutation_p.N343S|CTNND1_uc001nlp.3_Missense_Mutation_p.N343S|CTNND1_uc001nlx.3_Missense_Mutation_p.N74S|CTNND1_uc001nlz.3_Missense_Mutation_p.N74S|CTNND1_uc009ymn.2_Missense_Mutation_p.N74S|CTNND1_uc001nlm.3_Missense_Mutation_p.N397S|CTNND1_uc001nly.3_Missense_Mutation_p.N74S|CTNND1_uc001nmb.3_Missense_Mutation_p.N74S|CTNND1_uc001nma.3_Missense_Mutation_p.N74S|CTNND1_uc001nmi.3_Missense_Mutation_p.N296S|CTNND1_uc001nmh.3_Missense_Mutation_p.N397S|CTNND1_uc001nlq.3_Missense_Mutation_p.N296S|CTNND1_uc001nln.3_Missense_Mutation_p.N397S|CTNND1_uc001nli.3_Missense_Mutation_p.N397S|CTNND1_uc001nlo.3_Missense_Mutation_p.N296S|CTNND1_uc001nlv.3_Missense_Mutation_p.N296S	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	397					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TGCTACCGCAATGACAAGGTG	0.532			NA											4	78					0	0	0.000248	0	0
OR5B12	390191	broad.mit.edu	37	11	58206793	58206793	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:58206793T>C	uc010rkh.1	-	1	832	c.832A>G	c.(832-834)ATA>GTA	p.I278V		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGAATGACTATGGCATAGAAC	0.438			NA											10	31					0	0	0.006214	0	0
OR4D6	219983	broad.mit.edu	37	11	59225153	59225153	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:59225153C>A	uc010rku.1	+	1	720	c.720C>A	c.(718-720)TGC>TGA	p.C240*		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTCCACGTGCACGTCCCACA	0.572			NA											17	66					5.3912e-06	7.26217e-06	0.006122	1	0
FADS2	9415	broad.mit.edu	37	11	61608140	61608140	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:61608140C>G	uc001nsl.1	+	4	711	c.561C>G	c.(559-561)GTC>GTG	p.V187V	FADS2_uc001nsj.2_Silent_p.V165V|FADS2_uc010rlo.1_Silent_p.V156V|FADS2_uc001nsk.2_Silent_p.V187V	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	187	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	ACCTGTCTGTCTACAGAAAAC	0.547			NA											4	116					0	0	0.001168	0	0
AHNAK	79026	broad.mit.edu	37	11	62293116	62293116	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:62293116C>A	uc001ntl.2	-	5	9073	c.8773G>T	c.(8773-8775)GTC>TTC	p.V2925F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2925					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGGCCTGAGACATCAACGTCA	0.507			NA											79	242					3.54697e-40	7.16328e-40	0.00361	1	0
TUT1	64852	broad.mit.edu	37	11	62356644	62356644	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:62356644T>C	uc001nto.2	-	2	284	c.246A>G	c.(244-246)GTA>GTG	p.V82V		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	44					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTCGTAGTTCTACCAGGTGCC	0.532			NA											4	25					0	0	0.001168	0	0
MARK2	2011	broad.mit.edu	37	11	63671564	63671564	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:63671564A>T	uc001nxw.2	+	15	2200	c.1621A>T	c.(1621-1623)AAC>TAC	p.N541Y	MARK2_uc001nxx.2_Intron|MARK2_uc001nxy.2_Intron|MARK2_uc001nxv.3_Intron|MARK2_uc001nxz.3_Missense_Mutation_p.N507Y|MARK2_uc009yoy.2_Intron	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	541					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CGTGCACCCCAACAAGGCCTC	0.697			NA											4	15					0	0	0.000248	0	0
PYGM	5837	broad.mit.edu	37	11	64521742	64521742	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:64521742G>T	uc001oax.3	-	9	1892	c.1075C>A	c.(1075-1077)CGG>AGG	p.R359R	PYGM_uc001oay.3_Silent_p.R271R	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	359					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CAGTCCATCCGTTCCAGGTCC	0.632			NA											16	65					2.23348e-06	3.05455e-06	0.004007	1	0
SF3B2	10992	broad.mit.edu	37	11	65824815	65824815	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:65824815C>T	uc001ogy.1	+	7	786	c.746C>T	c.(745-747)CCC>CTC	p.P249L		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	249	Poly-Pro.				interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						CCTCGTGGTCCCCCACCGCCC	0.527			NA											8	139					0	0	0.00308	0	0
CTSF	8722	broad.mit.edu	37	11	66335045	66335045	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:66335045G>A	uc001oip.2	-	3	491	c.401C>T	c.(400-402)GCT>GTT	p.A134V		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	134					proteolysis	lysosome	cysteine-type endopeptidase activity				0						GGGCTCCCCAGCACCTGGAAC	0.557			NA											21	89					0	0	0.002299	0	0
SAPS3	55291	broad.mit.edu	37	11	68370837	68370837	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:68370837G>C	uc001onw.2	+	22	2594	c.2327G>C	c.(2326-2328)AGC>ACC	p.S776T	SAPS3_uc001onv.2_Missense_Mutation_p.S776T|SAPS3_uc001ony.3_Missense_Mutation_p.S747T|SAPS3_uc001onx.2_Missense_Mutation_p.S770T|SAPS3_uc009ysh.2_Missense_Mutation_p.S696T|SAPS3_uc001onu.2_Missense_Mutation_p.S696T|SAPS3_uc010rqc.1_Missense_Mutation_p.S544T|SAPS3_uc010rqd.1_Missense_Mutation_p.S459T|SAPS3_uc001onz.2_Missense_Mutation_p.S104T|SAPS3_uc001ooa.2_Missense_Mutation_p.S226T	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	776					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			ATGGAAGCCAGCTCTGACGGA	0.537			NA											19	76					0	0	0.007413	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748265	68748265	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:68748265T>C	uc010rqf.1	-	1	191	c.191A>G	c.(190-192)TAT>TGT	p.Y64C		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	64	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTTGAGGATATAGATGCAGAA	0.587			NA											9	40					0	0	0.008291	0	0
CTTN	2017	broad.mit.edu	37	11	70253623	70253623	+	Splice_Site	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:70253623G>C	uc001opv.3	+	4	294	c.88_splice	c.e4-1	p.N30_splice	CTTN_uc001opu.2_Splice_Site_p.N30_splice|CTTN_uc001opw.3_Splice_Site_p.N30_splice	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a							cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TTTCTTTTCAGAATGATGTGA	0.527			NA											20	89					0	0	0.001523	0	0
NADSYN1	55191	broad.mit.edu	37	11	71164426	71164426	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:71164426G>A	uc001oqn.2	+	1	210	c.84G>A	c.(82-84)AAG>AAA	p.K28K	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'Flank	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	28	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAATTTTAAAGAGTGAGTCTG	0.662	Ovarian(79;763 1781 6490 50276)		NA											3	10					0	0	0.004672	0	0
C2CD3	26005	broad.mit.edu	37	11	73796749	73796749	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:73796749T>C	uc001ouu.2	-	21	4051	c.3824A>G	c.(3823-3825)CAC>CGC	p.H1275R	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1275	C2 1.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TCCACTACAGTGCTGAGTCAC	0.498			NA											11	38					0	0	0.000978	0	0
CCDC83	220047	broad.mit.edu	37	11	85630410	85630410	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:85630410C>A	uc001pbh.1	+	11	1611	c.1099C>A	c.(1099-1101)CCC>ACC	p.P367T	CCDC83_uc001pbg.1_Missense_Mutation_p.P398T|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Missense_Mutation_p.P267T	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	367										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AAACTTGGGCCCCCTGGGAGT	0.408			NA											25	58					8.58068e-18	1.60723e-17	0.007291	1	0
GRM5	2915	broad.mit.edu	37	11	88780897	88780897	+	Silent	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:88780897A>C	uc001pcq.2	-	1	344	c.144T>G	c.(142-144)ACT>ACG	p.T48T	GRM5_uc009yvm.2_Silent_p.T48T|GRM5_uc009yvn.1_Silent_p.T48T	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	48	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CTTTGTCCACAGTAGGCTGGT	0.527			NA											15	39					0	0	0.006122	0	0
FOLH1B	219595	broad.mit.edu	37	11	89409322	89409322	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:89409322A>T	uc001pda.2	+	7	960	c.434A>T	c.(433-435)GAC>GTC	p.D145V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	145		Zinc 2 (By similarity).			proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ATTAATGCTGACTCATCTATA	0.373			NA											15	62					0	0	0.00499	0	0
Unknown	0	broad.mit.edu	37	11	89774425	89774425	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:89774425G>T	uc010rua.1	+	7	1189	c.1066G>T	c.(1066-1068)GGT>TGT	p.G356C		NM_020358	NP_065091			ring finger protein 18												NA						TTGGGCTTTTGGTGTCTGTAA	0.433			NA											18	34					2.48551e-13	4.31828e-13	0.00499	1	0
FAT3	120114	broad.mit.edu	37	11	92087375	92087375	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:92087375G>A	uc001pdj.3	+	1	2114	c.2097G>A	c.(2095-2097)AAG>AAA	p.K699K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	699	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TACTCATTAAGGCAAAAGCAA	0.383			NA								TCGA Ovarian(4;0.039)			41	104					0	0	0.005524	0	0
FAT3	120114	broad.mit.edu	37	11	92498135	92498135	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:92498135C>G	uc001pdj.3	+	5	4092	c.4075C>G	c.(4075-4077)CCA>GCA	p.P1359A		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1359	Cadherin 12.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCACCTATACCATTGACCTT	0.498			NA								TCGA Ovarian(4;0.039)			11	51					0	0	0.000978	0	0
FAT3	120114	broad.mit.edu	37	11	92613961	92613961	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:92613961C>G	uc001pdj.3	+	22	12209	c.12192C>G	c.(12190-12192)TGC>TGG	p.C4064W	FAT3_uc001pdi.3_Missense_Mutation_p.C504W	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4064	EGF-like 3.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTACAGCCTGCTTCCCAAACC	0.502			NA								TCGA Ovarian(4;0.039)			54	164					0	0	0.00361	0	0
MRE11A	4361	broad.mit.edu	37	11	94212876	94212876	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:94212876C>A	uc001peu.2	-	5	555	c.366G>T	c.(364-366)GTG>GTT	p.V122V	MRE11A_uc001pev.2_Silent_p.V122V|MRE11A_uc009ywj.2_Silent_p.V125V	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	122					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GAATACTAAACACTGGAATTG	0.348			NA						Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				15	44					2.94398e-08	4.37364e-08	0.007413	1	0
MMP20	9313	broad.mit.edu	37	11	102448108	102448108	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:102448108C>G	uc001phc.2	-	10	1414	c.1401G>C	c.(1399-1401)GAG>GAC	p.E467D		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	467	Hemopexin-like 4.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CATCTTCCTTCTCTGTGTCAT	0.388			NA											4	54					0	0	0.000248	0	0
CASP5	838	broad.mit.edu	37	11	104874094	104874094	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:104874094C>A	uc010rva.1	-	4	482	c.450G>T	c.(448-450)GAG>GAT	p.E150D	CASP5_uc010ruz.1_Missense_Mutation_p.E163D|CASP5_uc010rvb.1_Missense_Mutation_p.E92D|CASP5_uc010rvc.1_Missense_Mutation_p.E8D|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	150					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GTGGTCCAGCCTCGATTTGCA	0.403			NA											25	104					2.12542e-12	3.595e-12	0.00632	1	0
PPP2R1B	5519	broad.mit.edu	37	11	111623033	111623033	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:111623033G>C	uc001plx.1	-	10	1272	c.1188C>G	c.(1186-1188)ATC>ATG	p.I396M	PPP2R1B_uc001plw.1_Missense_Mutation_p.I396M|PPP2R1B_uc010rwi.1_Missense_Mutation_p.I332M|PPP2R1B_uc010rwj.1_Missense_Mutation_p.I235M|PPP2R1B_uc010rwk.1_Missense_Mutation_p.I351M|PPP2R1B_uc010rwl.1_Missense_Mutation_p.I269M	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	396	HEAT 10.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		AATTGGAGATGATATTCAAAC	0.448			NA											3	71					0	0	0.000248	0	0
HSPB2	3316	broad.mit.edu	37	11	111784584	111784584	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:111784584G>A	uc001pmg.2	+	2	608	c.514G>A	c.(514-516)GAG>AAG	p.E172K	CRYAB_uc001pmf.1_5'Flank|CRYAB_uc010rwp.1_5'Flank|HSPB2_uc009yyj.2_RNA|C11orf52_uc001pmh.2_Intron	NM_001541	NP_001532	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	172					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			ovary(2)|skin(1)	3		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		TCCTGATCCAGAGGAAGAGGA	0.572			NA											6	28					0	0	0.001984	0	0
HTR3B	9177	broad.mit.edu	37	11	113813800	113813800	+	Missense_Mutation	SNP	C	C	T	rs138362802	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:113813800C>T	uc001pok.2	+	7	860	c.793C>T	c.(793-795)CCC>TCC	p.P265S	HTR3B_uc001pol.2_Missense_Mutation_p.P254S	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	265	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CTACCTGCCACCCAACTGCCG	0.582			NA											10	39					0	0	0.008291	0	0
C11orf71	54494	broad.mit.edu	37	11	114270819	114270819	+	Missense_Mutation	SNP	C	C	A	rs1051890		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:114270819C>A	uc001pou.3	-	1	437	c.235G>T	c.(235-237)GAT>TAT	p.D79Y	C11orf71_uc001pot.1_Missense_Mutation_p.D79Y|RBM7_uc001pov.2_5'Flank|RBM7_uc001pow.2_5'Flank|RBM7_uc001pox.2_5'Flank	NM_019021	NP_061894	Q6IPW1	CK071_HUMAN	hypothetical protein LOC54494	79											0		all_cancers(61;1.15e-11)|all_epithelial(67;5.3e-06)|all_hematologic(158;0.000303)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.6e-06)|Epithelial(105;4.31e-05)|all cancers(92;0.00036)		CCCCGGCCATCTGGTTCCCTT	0.627			NA											15	48					3.27435e-08	4.84835e-08	0.00245	1	0
FAM55B	120406	broad.mit.edu	37	11	114569052	114569052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:114569052G>T	uc009yyy.2	+	3	516	c.418G>T	c.(418-420)GGA>TGA	p.G140*		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	140						integral to membrane				ovary(1)	1						GGACCACTTGGGACACAGGAA	0.552			NA											8	22					0.000157383	0.000191976	0.00308	1	0
APOA1	335	broad.mit.edu	37	11	116706556	116706556	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:116706556C>G	uc001ppu.1	-	4	851	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	APOA1_uc001ppv.1_Missense_Mutation_p.E258Q	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	258	10.|10 X approximate tandem repeats.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GTGTACTCCTCGAGAGCGCTC	0.622			NA											15	93					0	0	0.003163	0	0
CEP164	22897	broad.mit.edu	37	11	117234214	117234214	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:117234214G>C	uc001prc.2	+	8	904	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	CEP164_uc001prb.2_Missense_Mutation_p.E253Q|CEP164_uc010rxk.1_Intron|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	253					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GGGTGACTTTGAGTATGAGGT	0.458			NA											5	46					0	0	0.000602	0	0
CEP164	22897	broad.mit.edu	37	11	117265697	117265697	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:117265697G>C	uc001prc.2	+	22	2969	c.2822G>C	c.(2821-2823)AGA>ACA	p.R941T	CEP164_uc001prb.2_Missense_Mutation_p.R944T|CEP164_uc010rxk.1_Missense_Mutation_p.R915T|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.R374T	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	941	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GTCAAGGCCAGATTGGCTCTG	0.522			NA											29	99					0	0	0.008361	0	0
VPS11	55823	broad.mit.edu	37	11	118952213	118952213	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:118952213T>C	uc010ryx.1	+	17	2748	c.2706T>C	c.(2704-2706)TTT>TTC	p.F902F	VPS11_uc010ryy.1_Silent_p.F748F	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	902					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CTGACTACTTTGGCAGAGGTG	0.507			NA											39	125					0	0	0.002522	0	0
PVRL1	5818	broad.mit.edu	37	11	119548513	119548513	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:119548513C>A	uc001pwv.2	-	3	657	c.485G>T	c.(484-486)GGG>GTG	p.G162V	PVRL1_uc001pwu.1_Missense_Mutation_p.G162V|PVRL1_uc001pww.2_Missense_Mutation_p.G162V	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	162	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GTCATCCTGCCCCTTCTTGGC	0.562			NA											7	25					1.12685e-05	1.48953e-05	0.004482	1	0
OR10G8	219869	broad.mit.edu	37	11	123900548	123900548	+	Silent	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:123900548T>G	uc001pzp.1	+	1	219	c.219T>G	c.(217-219)ACT>ACG	p.T73T		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GGTTCTCCACTGTCACGGTGC	0.512			NA											31	112					0	0	0.001786	0	0
OR8B12	219858	broad.mit.edu	37	11	124413387	124413387	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:124413387T>A	uc010sam.1	-	1	164	c.164A>T	c.(163-165)CAC>CTC	p.H55L		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		CATGGGAGTGTGCAGGTGAGA	0.478			NA											20	75					0	0	0.001882	0	0
OR8A1	390275	broad.mit.edu	37	11	124440912	124440912	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:124440912C>A	uc010san.1	+	1	948	c.948C>A	c.(946-948)GCC>GCA	p.A316A		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	316	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TAAAGGCTGCCGTGCAGAAAA	0.438			NA											31	56					7.11191e-15	1.27012e-14	0.002836	1	0
PATE1	160065	broad.mit.edu	37	11	125618581	125618581	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:125618581A>T	uc001qct.2	+	5	346	c.334A>T	c.(334-336)AAC>TAC	p.N112Y	PATE1_uc009zbr.2_Missense_Mutation_p.N100Y	NM_138294	NP_612151	Q8WXA2	PATE1_HUMAN	expressed in prostate and testis precursor	112						extracellular region					0						CTATTTGGTGAACTTCAGGTG	0.488			NA											22	77					0	0	0.00333	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709201	128709201	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:128709201G>T	uc001qeo.1	-	2	1046	c.995C>A	c.(994-996)ACA>AAA	p.T332K	KCNJ1_uc001qep.1_Missense_Mutation_p.T313K|KCNJ1_uc001qeq.1_Missense_Mutation_p.T313K|KCNJ1_uc001qer.1_Missense_Mutation_p.T313K|KCNJ1_uc001qes.1_Missense_Mutation_p.T313K	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	332	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CCCTTCCTTTGTCTTGGATAC	0.498			NA											20	32					1.56452e-12	2.64963e-12	0.007413	1	0
KCNJ5	3762	broad.mit.edu	37	11	128781254	128781254	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:128781254C>A	uc001qet.2	+	2	400	c.86C>A	c.(85-87)GCC>GAC	p.A29D	KCNJ5_uc009zck.2_Missense_Mutation_p.A29D|KCNJ5_uc001qew.2_Missense_Mutation_p.A29D	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	29	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CCAAAACAGGCCCGCGATTAT	0.572	Pancreas(108;2548 5082)|Esophageal Squamous(165;4544 6231)		NA											14	63					4.3838e-07	6.19079e-07	0.001855	1	0
KCNJ5	3762	broad.mit.edu	37	11	128786491	128786491	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:128786491G>A	uc001qet.2	+	3	1439	c.1125G>A	c.(1123-1125)CGG>CGA	p.R375R	KCNJ5_uc009zck.2_Silent_p.R375R|KCNJ5_uc001qew.2_Silent_p.R375R	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	375	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GGGAAGGCCGGCTCCTCCAGT	0.592	Pancreas(108;2548 5082)|Esophageal Squamous(165;4544 6231)		NA											11	64					0	0	0.001368	0	0
ST14	6768	broad.mit.edu	37	11	130069888	130069888	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:130069888G>T	uc001qfw.2	+	16	2043	c.1850G>T	c.(1849-1851)GGG>GTG	p.G617V		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	617	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CGTGTTGTTGGGGGCACGGAT	0.612			NA											11	50					1.08611e-07	1.56675e-07	0.000978	1	0
FBXL14	144699	broad.mit.edu	37	12	1702803	1702803	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:1702803C>T	uc001qjh.2	-	1	529	c.430G>A	c.(430-432)GGC>AGC	p.G144S	WNT5B_uc009zdq.2_Intron|FBXL14_uc001qji.2_Missense_Mutation_p.G56S	NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	144	LRR 1.					cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			ACCTCCAGGCCCTTGAGGTAC	0.622			NA											4	67					0	0	0.000248	0	0
CACNA1C	775	broad.mit.edu	37	12	2742805	2742805	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:2742805G>T	uc009zdu.1	+	31	4212	c.3899G>T	c.(3898-3900)AGT>ATT	p.S1300I	CACNA1C_uc009zdv.1_Missense_Mutation_p.S1277I|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Missense_Mutation_p.S1300I|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Missense_Mutation_p.S1280I|CACNA1C_uc001qkr.2_Missense_Mutation_p.S1280I|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Missense_Mutation_p.S1280I|CACNA1C_uc001qks.2_Missense_Mutation_p.S1280I|CACNA1C_uc001qkt.2_Missense_Mutation_p.S1280I|CACNA1C_uc001qki.1_Missense_Mutation_p.S1016I|CACNA1C_uc001qkj.1_Missense_Mutation_p.S1016I|CACNA1C_uc001qkk.1_Missense_Mutation_p.S1016I|CACNA1C_uc001qkm.1_Intron	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1300	Cytoplasmic (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTACTTTAGTGATCCCTGG	0.443			NA											16	100					1.5739e-10	2.54668e-10	0.004007	1	0
NRIP2	83714	broad.mit.edu	37	12	2936794	2936794	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:2936794G>C	uc001qlc.2	-	5	822	c.750C>G	c.(748-750)CTC>CTG	p.L250L	ITFG2_uc010sec.1_Intron|NRIP2_uc010sed.1_Silent_p.L250L	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	250					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCCTTACCTTGAGAGAAAGCA	0.507			NA											5	255					0	0	0.001984	0	0
PRMT8	56341	broad.mit.edu	37	12	3702309	3702309	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:3702309G>C	uc001qmf.2	+	10	1513	c.1146G>C	c.(1144-1146)CTG>CTC	p.L382L	PRMT8_uc009zed.2_Silent_p.L373L|PRMT8_uc001qmg.2_Silent_p.L196L|PRMT8_uc001qmh.2_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	382					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			AGGGACAGCTGTGTGAAACAT	0.517			NA											7	28					0	0	0.001984	0	0
SCNN1A	6337	broad.mit.edu	37	12	6458494	6458494	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:6458494T>A	uc001qnx.2	-	9	1727	c.1438A>T	c.(1438-1440)AGC>TGC	p.S480C	SCNN1A_uc001qnv.2_Missense_Mutation_p.S180C|SCNN1A_uc001qnw.2_Missense_Mutation_p.S539C|SCNN1A_uc010sfb.1_Missense_Mutation_p.S503C	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	480	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GACACTAACCTGCATGGCTTC	0.547			NA											6	13					0	0	0.001168	0	0
AICDA	57379	broad.mit.edu	37	12	8759494	8759494	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:8759494G>C	uc001qur.2	-	2	202	c.123C>G	c.(121-123)TCC>TCG	p.S41S	AICDA_uc001qup.1_Silent_p.S36S|AICDA_uc001quq.1_Silent_p.S36S|AICDA_uc009zgd.1_RNA	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	41					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					CCAGTGAAAAGGATGTAGCAC	0.463	GBM(62;896 1067 5527 26594 30137)		NA							Immune_Deficiency_with_Hyper-IgM				4	52					0	0	0.000248	0	0
PZP	5858	broad.mit.edu	37	12	9354948	9354948	+	Silent	SNP	G	G	T	rs143334338		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:9354948G>T	uc001qvl.2	-	4	476	c.447C>A	c.(445-447)TCC>TCA	p.S149S	PZP_uc009zgl.2_Silent_p.S18S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTCATCCACGGAGACAACAC	0.453	Melanoma(125;1402 1695 4685 34487 38571)		NA											4	74					0.00116845	0.00137772	0.001168	1	0
TAS2R30	259293	broad.mit.edu	37	12	11286614	11286614	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:11286614C>A	uc009zhs.1	-	1	230	c.230G>T	c.(229-231)AGT>ATT	p.S77I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						TACTTCTACACTATAAAAAGC	0.423			NA											14	170					1.5842e-08	2.38251e-08	0.001855	1	0
GRIN2B	2904	broad.mit.edu	37	12	13716789	13716789	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:13716789C>A	uc001rbt.2	-	13	3562	c.3383G>T	c.(3382-3384)GGG>GTG	p.G1128V		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1128	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCCCGTAGCCCTTCCTTGTC	0.607			NA											19	29					1.37657e-19	2.62977e-19	0.001882	1	0
GRIN2B	2904	broad.mit.edu	37	12	13716964	13716964	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:13716964A>T	uc001rbt.2	-	13	3387	c.3208T>A	c.(3208-3210)TAT>AAT	p.Y1070N		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1070	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGTTCCCATAGGTGACGGTG	0.567			NA											10	19					0	0	0.000978	0	0
PLCZ1	89869	broad.mit.edu	37	12	18858220	18858220	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:18858220T>A	uc010sid.1	-	7	935	c.744A>T	c.(742-744)TTA>TTT	p.L248F	PLCZ1_uc001rdv.3_Missense_Mutation_p.L144F|PLCZ1_uc001rdw.3_5'UTR|PLCZ1_uc001rdu.1_Splice_Site|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	248	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AGTGATTTTCTAAAGAGAGCA	0.368			NA											85	99					0	0	0.00361	0	0
PDE3A	5139	broad.mit.edu	37	12	20522936	20522936	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:20522936C>A	uc001reh.1	+	1	740	c.718C>A	c.(718-720)CTG>ATG	p.L240M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	240	Helical; (Potential).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GAGACCTTACCTGGCGTACCT	0.622			NA											27	38					9.80776e-20	1.87633e-19	0.00632	1	0
PDE3A	5139	broad.mit.edu	37	12	20783002	20783002	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:20783002C>A	uc001reh.1	+	6	1723	c.1701C>A	c.(1699-1701)TAC>TAA	p.Y567*		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	567					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCTTAACTTACACTCAGAGTG	0.443			NA											89	129					3.71036e-49	7.52721e-49	0.00361	1	0
SOX5	6660	broad.mit.edu	37	12	23793749	23793749	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:23793749C>A	uc001rfw.2	-	8	1116	c.1014G>T	c.(1012-1014)CTG>CTT	p.L338L	SOX5_uc001rfx.2_Silent_p.L325L|SOX5_uc001rfy.2_Silent_p.L325L|SOX5_uc010siv.1_Silent_p.L325L|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Silent_p.L290L	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	338					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GACTTACCTGCAGTTGGAGTG	0.433			NA											18	123					3.70931e-20	7.12677e-20	0.006122	1	0
TMTC1	83857	broad.mit.edu	37	12	29904696	29904696	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:29904696G>A	uc001rjb.2	-	5	991	c.517C>T	c.(517-519)CAC>TAC	p.H173Y	TMTC1_uc001rjc.1_Missense_Mutation_p.H173Y	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	281						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GCTCCTTTGTGAGGGAACCGC	0.552			NA											13	20					0	0	0.001855	0	0
TMTC1	83857	broad.mit.edu	37	12	29920927	29920927	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:29920927C>A	uc001rjb.2	-	2	534	c.60G>T	c.(58-60)GTG>GTT	p.V20V	TMTC1_uc001rjc.1_Silent_p.V20V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	128	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGTACATCAGCACAAGAGTCA	0.358			NA											19	26					3.99206e-14	7.06368e-14	0.007413	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30888056	30888056	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:30888056G>C	uc001rji.1	-	4	1406	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	CAPRIN2_uc001rjf.1_Missense_Mutation_p.Q16E|CAPRIN2_uc001rjg.1_5'UTR|CAPRIN2_uc001rjh.1_Missense_Mutation_p.Q219E|CAPRIN2_uc001rjj.1_5'UTR|CAPRIN2_uc001rjk.3_Missense_Mutation_p.Q219E|CAPRIN2_uc001rjl.3_Missense_Mutation_p.Q219E	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	219					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TACTGAACTTGAAGTATAGTT	0.408			NA											66	133					0	0	0.00361	0	0
FGD4	121512	broad.mit.edu	37	12	32793217	32793217	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:32793217G>C	uc001rkz.2	+	17	2528	c.2051G>C	c.(2050-2052)AGA>ACA	p.R684T	FGD4_uc001rlc.2_Missense_Mutation_p.R769T|FGD4_uc001rla.2_Missense_Mutation_p.R340T|FGD4_uc010ske.1_Missense_Mutation_p.R796T|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	684	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TAGGACGTCAGAGCCCAGGCC	0.488			NA											5	185					0	0	0.001168	0	0
LRRK2	120892	broad.mit.edu	37	12	40677725	40677725	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:40677725A>T	uc001rmg.3	+	19	2411	c.2290A>T	c.(2290-2292)AGT>TGT	p.S764C	LRRK2_uc001rmh.1_Missense_Mutation_p.S386C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	764					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTTACTGAATAGTGGATCTCG	0.388			NA											22	59					0	0	0.00333	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42854219	42854219	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:42854219G>C	uc010skv.1	-	8	2175	c.1888C>G	c.(1888-1890)CAG>GAG	p.Q630E	PRICKLE1_uc001rnl.2_Missense_Mutation_p.Q630E|PRICKLE1_uc010skw.1_Missense_Mutation_p.Q630E|PRICKLE1_uc001rnm.2_Missense_Mutation_p.Q630E|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	630					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		AACTTGACCTGCTGGGGTCTG	0.478			NA											6	72					0	0	0.000978	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43828094	43828094	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:43828094G>T	uc010skx.1	-	19	2674	c.2674C>A	c.(2674-2676)CTT>ATT	p.L892I	ADAMTS20_uc001rno.1_Missense_Mutation_p.L46I|ADAMTS20_uc001rnp.1_Missense_Mutation_p.L46I	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	892	TSP type-1 2.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AATGATGGAAGTGGCAAGTGG	0.338			NA											7	12					0.000157383	0.000191976	0.00308	1	0
ARID2	196528	broad.mit.edu	37	12	46244208	46244208	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:46244208G>T	uc001ros.1	+	15	2302	c.2302G>T	c.(2302-2304)GTA>TTA	p.V768L	ARID2_uc001ror.2_Missense_Mutation_p.V768L|ARID2_uc009zkg.1_Missense_Mutation_p.V224L|ARID2_uc009zkh.1_Missense_Mutation_p.V395L|ARID2_uc001rou.1_Missense_Mutation_p.V102L	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	768					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCATCCATCTGTAATTCCACA	0.463			NA											6	24					3.59834e-05	4.57629e-05	0.001168	1	0
MLL2	8085	broad.mit.edu	37	12	49420538	49420538	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:49420538C>G	uc001rta.3	-	48	15211	c.15211G>C	c.(15211-15213)GAG>CAG	p.E5071Q		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5071					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCTGGGTCTCATACACCTCC	0.637			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	50					0	0	0.004672	0	0
ACVRL1	94	broad.mit.edu	37	12	52306269	52306269	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:52306269G>A	uc001rzj.2	+	2	294	c.11G>A	c.(10-12)GGC>GAC	p.G4D	ACVRL1_uc001rzk.2_Missense_Mutation_p.G4D|ACVRL1_uc010snm.1_Missense_Mutation_p.G18D	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	4					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	ATGACCTTGGGCTCCCCCAGG	0.587			NA							Hereditary_Hemorrhagic_Telangiectasia				8	22					0	0	0.004482	0	0
KRT85	3891	broad.mit.edu	37	12	52758745	52758745	+	Splice_Site	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:52758745C>T	uc001sag.2	-	2	749	c.629_splice	c.e2+1	p.K210_splice		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85						epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGCACTCACTTCTTCTTGT	0.607			NA											22	101					0	0	0.001882	0	0
KRT4	3851	broad.mit.edu	37	12	53203200	53203200	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:53203200G>A	uc001saz.2	-	4	1294	c.1023C>T	c.(1021-1023)GAC>GAT	p.D341D		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	267						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						AGTTGATCTCGTCATTAAGAC	0.557	Pancreas(190;284 2995 41444 45903)		NA											6	75					0	0	0.001984	0	0
ITGA5	3678	broad.mit.edu	37	12	54802689	54802689	+	Silent	SNP	G	G	A	rs147213910		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:54802689G>A	uc001sga.2	-	5	701	c.633C>T	c.(631-633)GCC>GCT	p.A211A	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	211	Extracellular (Potential).|FG-GAP 3.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						TGGTGAACTCGGCACTGAAGC	0.577			NA											4	50					0	0	0.000248	0	0
SDR9C7	121214	broad.mit.edu	37	12	57324168	57324168	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:57324168C>T	uc010sqw.1	-	2	402	c.402G>A	c.(400-402)CTG>CTA	p.L134L		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	134						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						TCAGTCCCACCAGGTTCACAT	0.572			NA											12	40					0	0	0.001855	0	0
R3HDM2	22864	broad.mit.edu	37	12	57662768	57662768	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:57662768C>A	uc009zpm.1	-	15	1805	c.1770G>T	c.(1768-1770)AGG>AGT	p.R590S	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.R285S|R3HDM2_uc001snr.2_Missense_Mutation_p.R317S|R3HDM2_uc001sns.2_Missense_Mutation_p.R590S|R3HDM2_uc001snt.2_Missense_Mutation_p.R604S|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	590	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						CCATGCTGCTCCTCTGGCTGC	0.582			NA											9	86					1.12685e-05	1.48953e-05	0.004482	1	0
ARHGAP9	64333	broad.mit.edu	37	12	57872980	57872980	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:57872980G>A	uc001sod.2	-	5	616	c.423C>T	c.(421-423)CCC>CCT	p.P141P	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Silent_p.P70P|ARHGAP9_uc001soc.2_Silent_p.P70P|ARHGAP9_uc001soe.1_Silent_p.P149P|ARHGAP9_uc010sro.1_Silent_p.P70P	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	70	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			GAGAGGTGGAGGGAGCTTCTA	0.567			NA											7	67					0	0	0.001984	0	0
C12orf66	144577	broad.mit.edu	37	12	64587833	64587833	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:64587833T>C	uc001srw.3	-	3	1186	c.1127A>G	c.(1126-1128)AAC>AGC	p.N376S	C12orf66_uc009zql.2_Missense_Mutation_p.N323S	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	376										ovary(1)	1						CTCCAAGCTGTTCAGATCAGA	0.498			NA											32	94					0	0	0.002096	0	0
CPSF6	11052	broad.mit.edu	37	12	69653891	69653891	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:69653891T>C	uc001sut.3	+	8	1493	c.1383T>C	c.(1381-1383)TCT>TCC	p.S461S	CPSF6_uc001suu.3_Silent_p.S498S|CPSF6_uc010stk.1_Silent_p.S92S	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	461					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CCAAAGTATCTGCTGATGATC	0.259			NA											11	46					0	0	0.008291	0	0
PTPRB	5787	broad.mit.edu	37	12	71029518	71029518	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:71029518A>T	uc001swc.3	-	2	428	c.384T>A	c.(382-384)CAT>CAA	p.H128Q	PTPRB_uc001swa.3_Missense_Mutation_p.H128Q|PTPRB_uc001swd.3_Missense_Mutation_p.H127Q|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Missense_Mutation_p.H128Q	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCATCCAGCTATGGAGGTATT	0.443			NA											12	38					0	0	0.001368	0	0
PTPRR	5801	broad.mit.edu	37	12	71078512	71078512	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:71078512C>A	uc001swi.1	-	9	1747	c.1331G>T	c.(1330-1332)AGC>ATC	p.S444I	PTPRR_uc001swh.1_Missense_Mutation_p.S199I|PTPRR_uc009zrs.2_Missense_Mutation_p.S293I|PTPRR_uc010stq.1_Missense_Mutation_p.S332I|PTPRR_uc010str.1_Missense_Mutation_p.S293I	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	444	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AATGTAGGTGCTCAATGAATC	0.294			NA											15	83					8.60227e-14	1.51018e-13	0.004007	1	0
TPH2	121278	broad.mit.edu	37	12	72335394	72335394	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:72335394G>T	uc009zrw.1	+	2	277	c.136G>T	c.(136-138)GAC>TAC	p.D46Y	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	46					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CAAAAATGACGACAAAGGCAA	0.393			NA											6	26					3.59834e-05	4.57629e-05	0.001168	1	0
NAV3	89795	broad.mit.edu	37	12	78542673	78542673	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:78542673A>G	uc001syp.2	+	22	4932	c.4759A>G	c.(4759-4761)ACC>GCC	p.T1587A	NAV3_uc001syo.2_Missense_Mutation_p.T1587A|NAV3_uc010sub.1_Missense_Mutation_p.T1073A|NAV3_uc009zsf.2_Missense_Mutation_p.T418A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1587	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAAAGTTGCTACCCTCACATC	0.308			NA								HNSCC(70;0.22)			8	17					0	0	0.004482	0	0
RASSF9	9182	broad.mit.edu	37	12	86199574	86199574	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:86199574C>T	uc001taf.1	-	2	553	c.214G>A	c.(214-216)GGG>AGG	p.G72R		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	72	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						CTGGGCTTCCCCAGAAGAAAT	0.502			NA											15	73					0	0	0.003163	0	0
C12orf12	196477	broad.mit.edu	37	12	91347470	91347470	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:91347470G>T	uc001tbj.2	-	1	1484	c.1050C>A	c.(1048-1050)AAC>AAA	p.N350K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	350	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						CTCTCTGCTCGTTCTCCTCCA	0.244			NA											12	46					1.52009e-12	2.58743e-12	0.003163	1	0
SLC17A8	246213	broad.mit.edu	37	12	100796415	100796415	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:100796415G>T	uc010svi.1	+	8	1258	c.945G>T	c.(943-945)CCG>CCT	p.P315P	SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	315	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						CATCTTTGCCGGTTTATGCAA	0.338			NA											27	61					4.22769e-11	6.95808e-11	0.00632	1	0
ANO4	121601	broad.mit.edu	37	12	101333107	101333107	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:101333107A>G	uc010svm.1	+	4	747	c.175A>G	c.(175-177)AAT>GAT	p.N59D	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.N24D|ANO4_uc001thx.2_Missense_Mutation_p.N59D	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	59	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CAAGGATGTCAATATTCTTTT	0.398			NA								HNSCC(74;0.22)			20	112					0	0	0.001882	0	0
ANO4	121601	broad.mit.edu	37	12	101505362	101505362	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:101505362A>T	uc010svm.1	+	24	2896	c.2324A>T	c.(2323-2325)GAA>GTA	p.E775V	ANO4_uc001thw.2_Missense_Mutation_p.E740V|ANO4_uc001thx.2_Missense_Mutation_p.E775V|ANO4_uc001thy.2_Missense_Mutation_p.E295V	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	775	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGAATTCTTGAAGGCATTGGA	0.328			NA								HNSCC(74;0.22)			18	39					0	0	0.001882	0	0
EID3	493861	broad.mit.edu	37	12	104698266	104698266	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:104698266G>A	uc001tkw.2	+	1	718	c.554G>A	c.(553-555)CGA>CAA	p.R185Q	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						CCAAAGCCCCGACTTGAACAC	0.423			NA											52	132					0	0	0.00361	0	0
CHST11	50515	broad.mit.edu	37	12	105151069	105151069	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:105151069C>T	uc001tkx.1	+	4	838	c.547C>T	c.(547-549)CTG>TTG	p.L183L	CHST11_uc001tky.2_Silent_p.L178L|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	183	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						CATGAAGTTCCTGTTTGTCCG	0.547			NA											11	53					0	0	0.001368	0	0
ATP2A2	488	broad.mit.edu	37	12	110760866	110760866	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:110760866C>T	uc001tqk.3	+	6	1096	c.533C>T	c.(532-534)TCA>TTA	p.S178L	ATP2A2_uc001tql.3_Missense_Mutation_p.S178L|ATP2A2_uc010sxy.1_Intron	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	178	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GTTGACCAGTCAATTCTCACA	0.378			NA											12	71					0	0	0.00245	0	0
LHX5	64211	broad.mit.edu	37	12	113906943	113906943	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:113906943C>G	uc001tvj.1	-	2	955	c.381G>C	c.(379-381)GAG>GAC	p.E127D		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	127						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAGGCTGCCCTCCTTGAGGC	0.607			NA											4	13					0	0	0.000602	0	0
KSR2	283455	broad.mit.edu	37	12	118020126	118020126	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:118020126G>A	uc001two.2	-	6	1178	c.1123C>T	c.(1123-1125)CGC>TGC	p.R375C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	404					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGATCTCTGCGAGGGATCTGC	0.592			NA											15	80					0	0	0.006122	0	0
LRRC43	254050	broad.mit.edu	37	12	122675978	122675978	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:122675978G>A	uc009zxm.2	+	6	978	c.953G>A	c.(952-954)GGA>GAA	p.G318E	LRRC43_uc001ubw.3_Missense_Mutation_p.G133E|LRRC43_uc009zxn.2_Missense_Mutation_p.G79E	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	318											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		AACATCAGAGGAGTCCTGGAC	0.527			NA									OREG0022219	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	45					0	0	0.003163	0	0
SBNO1	55206	broad.mit.edu	37	12	123801789	123801789	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:123801789C>A	uc010tap.1	-	20	2914	c.2914G>T	c.(2914-2916)GAT>TAT	p.D972Y	SBNO1_uc010tao.1_Missense_Mutation_p.D971Y|SBNO1_uc010taq.1_Intron|SBNO1_uc001ues.1_5'Flank	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	972							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATTGCTCTATCAGCGCTCCAA	0.413			NA											11	61					1.08611e-07	1.56675e-07	0.000978	1	0
DNAH10	196385	broad.mit.edu	37	12	124382337	124382337	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:124382337G>T	uc001uft.3	+	54	8972	c.8947G>T	c.(8947-8949)GCA>TCA	p.A2983S		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2983	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AATGATCCCGGCAGAAAATAT	0.303			NA											17	73					3.45872e-05	4.44929e-05	0.004007	1	0
GLT1D1	144423	broad.mit.edu	37	12	129373192	129373192	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:129373192A>G	uc010tbh.1	+	3	202	c.193A>G	c.(193-195)ATC>GTC	p.I65V	GLT1D1_uc001uhx.1_Missense_Mutation_p.I76V|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	76					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		AGGCCACCGAATCCCTTTTGG	0.453			NA											6	31					0	0	0.00308	0	0
FZD10	11211	broad.mit.edu	37	12	130648759	130648759	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:130648759G>C	uc001uii.2	+	1	1728	c.1272G>C	c.(1270-1272)CGG>CGC	p.R424R	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	424	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCCACATCCGGAGGGTGATGA	0.622			NA											12	47					0	0	0.000978	0	0
POLE	5426	broad.mit.edu	37	12	133218360	133218360	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:133218360C>A	uc001uks.1	-	39	5295	c.5251G>T	c.(5251-5253)GCC>TCC	p.A1751S	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.A555S|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1751					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ATGCTGTCGGCCCCCTCCATG	0.607			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	27					1.12685e-05	1.48953e-05	0.004482	1	0
PXMP2	5827	broad.mit.edu	37	12	133277921	133277921	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:133277921T>A	uc001ukt.2	+	4	550	c.485T>A	c.(484-486)CTA>CAA	p.L162Q	PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	162	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		TGGACGCCACTACAGTTCATC	0.537			NA											18	50					0	0	0.00499	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768245	41768245	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:41768245A>G	uc001uxw.1	-	1	458	c.149T>C	c.(148-150)CTG>CCG	p.L50P	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	50							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GAGCTGTGCCAGCAGGGCTGC	0.627			NA											38	55					0	0	0.00623	0	0
ZC3H13	23091	broad.mit.edu	37	13	46549882	46549882	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:46549882C>A	uc010tfw.1	-	11	2010	c.2004G>T	c.(2002-2004)GTG>GTT	p.V668V	ZC3H13_uc001vas.1_Silent_p.V668V|ZC3H13_uc001vat.1_Silent_p.V668V	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	668	Arg/Glu-rich.|Potential.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCCTATCATCCACTCTGTCTA	0.284	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											7	20					3.09899e-07	4.40883e-07	0.004482	1	0
C13orf18	80183	broad.mit.edu	37	13	46935586	46935586	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:46935586G>C	uc010acl.2	-	8	1714	c.1109C>G	c.(1108-1110)GCT>GGT	p.A370G	C13orf18_uc001vbf.3_Missense_Mutation_p.A303G|C13orf18_uc001vbg.3_Missense_Mutation_p.A98G|C13orf18_uc010tfz.1_Missense_Mutation_p.A213G|C13orf18_uc010acm.2_Missense_Mutation_p.A235G|C13orf18_uc010acn.2_Missense_Mutation_p.A155G|C13orf18_uc001vbe.3_Missense_Mutation_p.A370G|C13orf18_uc001vbh.3_Missense_Mutation_p.A370G|C13orf18_uc001vbi.3_Missense_Mutation_p.A213G|C13orf18_uc010aco.1_Missense_Mutation_p.A370G	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	370											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		TATCGAGCCAGCTGCACTCAG	0.418			NA											8	29					0	0	0.004482	0	0
CAB39L	81617	broad.mit.edu	37	13	49951112	49951112	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:49951112T>C	uc001vcw.2	-	3	765	c.267A>G	c.(265-267)ATA>ATG	p.I89M	CAB39L_uc001vcx.2_Missense_Mutation_p.I89M|CAB39L_uc010adf.2_Missense_Mutation_p.I86M	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	89					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		CCTCAAAGTCTATCAGCTGCA	0.383			NA											24	39					0	0	0.005443	0	0
SETDB2	83852	broad.mit.edu	37	13	50062476	50062476	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:50062476G>C	uc001vcz.2	+	13	2569	c.1663G>C	c.(1663-1665)GAA>CAA	p.E555Q	SETDB2_uc010adh.2_3'UTR|SETDB2_uc001vda.2_Missense_Mutation_p.E543Q	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	555	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		TCTGCTGATTGAATCAGATGT	0.358			NA											9	71					0	0	0.006214	0	0
CCDC70	83446	broad.mit.edu	37	13	52439669	52439669	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:52439669G>A	uc001vfu.3	+	2	451	c.155G>A	c.(154-156)CGC>CAC	p.R52H	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	52						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AAGGCTTTTCGCGAAGAGATG	0.512			NA											5	43					0	0	0.000602	0	0
OLFM4	10562	broad.mit.edu	37	13	53617354	53617354	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:53617354T>A	uc001vhl.2	+	4	685	c.685T>A	c.(685-687)TCT>ACT	p.S229T	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	229	Potential.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GTGTGAGGCCTCTAAAGATCA	0.493			NA											22	59					0	0	0.001882	0	0
KLF12	11278	broad.mit.edu	37	13	74420040	74420040	+	Silent	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:74420040T>G	uc001vjf.2	-	4	816	c.594A>C	c.(592-594)ACA>ACC	p.T198T	KLF12_uc010aeq.2_Silent_p.T198T|KLF12_uc001vjg.3_Silent_p.T198T	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	198					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		ACCTTACAGCTGTGTAGACAA	0.493			NA											20	109					0	0	0.00333	0	0
LMO7	4008	broad.mit.edu	37	13	76382280	76382280	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:76382280G>A	uc001vjv.2	+	7	1922	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Missense_Mutation_p.E294K	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	673						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GAAGAGATGGGAGGCCATCCG	0.532			NA											7	52					0	0	0.00308	0	0
GPC5	2262	broad.mit.edu	37	13	92560270	92560270	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:92560270G>T	uc010tif.1	+	6	1726	c.1360G>T	c.(1360-1362)GTG>TTG	p.V454L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	454						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AATTGATCCTGTGATAAATCA	0.353			NA											10	46					3.07112e-06	4.16617e-06	0.000978	1	0
DCT	1638	broad.mit.edu	37	13	95131399	95131399	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:95131399G>T	uc001vlv.3	-	1	538	c.111C>A	c.(109-111)AAC>AAA	p.N37K	DCT_uc010afh.2_Missense_Mutation_p.N37K	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	37	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGCACTCCTTGTTCACTAGGC	0.622			NA											13	37					0.00010058	0.000124382	0.001368	1	0
GPR183	1880	broad.mit.edu	37	13	99948198	99948198	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:99948198G>A	uc001vog.2	-	2	376	c.202C>T	c.(202-204)CTC>TTC	p.L68F	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron	NM_004951	NP_004942	P32249	GP183_HUMAN	EBV-induced G protein-coupled receptor 2	68	Cytoplasmic (Potential).				humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0						GTTGAATAGAGGGTGGTAGAG	0.433			NA											9	57					0	0	0.006214	0	0
ITGBL1	9358	broad.mit.edu	37	13	102359230	102359230	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:102359230T>A	uc001vpb.2	+	9	1476	c.1257T>A	c.(1255-1257)GAT>GAA	p.D419E	ITGBL1_uc010agb.2_Missense_Mutation_p.D370E|ITGBL1_uc001vpc.3_Missense_Mutation_p.D278E	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	419	IX.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATCAGCAGATGGCATATTGT	0.478			NA											5	138					0	0	0.001168	0	0
SOX1	6656	broad.mit.edu	37	13	112722023	112722023	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:112722023G>C	uc001vsb.1	+	1	111	c.51G>C	c.(49-51)CAG>CAC	p.Q17H		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	17					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		GCGGCGCCCAGGCCCCCACGA	0.562			NA											5	16					0	0	0.001984	0	0
ATP11A	23250	broad.mit.edu	37	13	113481158	113481158	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:113481158G>T	uc001vsi.3	+	12	1262	c.1174G>T	c.(1174-1176)GAG>TAG	p.E392*	ATP11A_uc001vsj.3_Nonsense_Mutation_p.E392*|ATP11A_uc001vsm.1_Nonsense_Mutation_p.E268*	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	392	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GGAGACTGGCGAGGGGCCTCT	0.527			NA											12	60					5.50884e-06	7.37624e-06	0.001368	1	0
F7	2155	broad.mit.edu	37	13	113771128	113771128	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:113771128G>T	uc001vsv.2	+	7	671	c.620G>T	c.(619-621)AGC>ATC	p.S207I	F7_uc010agp.1_Missense_Mutation_p.S200I|F7_uc001vsw.2_Missense_Mutation_p.S185I|F7_uc010tjt.1_Missense_Mutation_p.S138I	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	207					anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	AGAAATGCCAGCAAACCCCAA	0.483			NA											14	110					2.23348e-06	3.05455e-06	0.004007	1	0
F7	2155	broad.mit.edu	37	13	113772915	113772915	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:113772915A>T	uc001vsv.2	+	9	1045	c.994A>T	c.(994-996)ACG>TCG	p.T332S	F7_uc001vsw.2_Missense_Mutation_p.T310S|F7_uc010tjt.1_Missense_Mutation_p.T263S	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	332	Peptidase S1.		T -> M (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	CTCTGAGAGGACGCTGGCCTT	0.677			NA											5	33					0	0	0.001984	0	0
CUL4A	8451	broad.mit.edu	37	13	113893788	113893788	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:113893788G>T	uc010tjy.1	+	11	969	c.958G>T	c.(958-960)GCA>TCA	p.A320S	CUL4A_uc010tjx.1_Missense_Mutation_p.A220S|CUL4A_uc010agu.2_Missense_Mutation_p.A181S|CUL4A_uc010tjz.1_5'UTR	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	320					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GCCGGACCTCGCACAGATGTA	0.582			NA											28	55					7.41945e-09	1.12974e-08	0.005443	1	0
OR11H12	440153	broad.mit.edu	37	14	19378073	19378073	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:19378073C>A	uc010tkp.1	+	1	480	c.480C>A	c.(478-480)GTC>GTA	p.V160V		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCAAACTGGTCATACTGTGCT	0.473			NA											25	295					2.79863e-10	4.48516e-10	0.004656	1	0
OR4N2	390429	broad.mit.edu	37	14	20295688	20295688	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:20295688C>A	uc010tkv.1	+	1	81	c.81C>A	c.(79-81)GTC>GTA	p.V27V		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTCCTGGTCTTTGTGCTAG	0.438			NA											15	166					4.7546e-09	7.32274e-09	0.004007	1	0
OR4K2	390431	broad.mit.edu	37	14	20344723	20344723	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:20344723C>A	uc001vwh.1	+	1	297	c.297C>A	c.(295-297)ACC>ACA	p.T99T		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTGCCTTACCCAGATATTCT	0.413			NA											19	83					8.00594e-06	1.06985e-05	0.007413	1	0
OR4K14	122740	broad.mit.edu	37	14	20483114	20483114	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:20483114G>A	uc010tky.1	-	1	239	c.239C>T	c.(238-240)CCC>CTC	p.P80L		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	80	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GATCATCTTGGGAGTGGCAAA	0.488			NA											3	26					0	0	0.004672	0	0
RNASE13	440163	broad.mit.edu	37	14	21502328	21502328	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:21502328G>T	uc001vzj.2	-	2	258	c.120C>A	c.(118-120)CCC>CCA	p.P40P	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	40						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		AGTTAACCCTGGGATAGTCAA	0.468			NA											12	55					5.50884e-06	7.37624e-06	0.001368	1	0
CMTM5	116173	broad.mit.edu	37	14	23847665	23847665	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:23847665C>T	uc010akm.2	+	2	678	c.234C>T	c.(232-234)GCC>GCT	p.A78A	CMTM5_uc001wjs.2_Silent_p.A78A|CMTM5_uc001wjt.2_Silent_p.A78A|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	78	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		TCCTCTATGCCACCCAGTACT	0.562			NA											17	95					0	0	0.007413	0	0
NOVA1	4857	broad.mit.edu	37	14	26917911	26917911	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:26917911C>A	uc001wpy.2	-	5	1096	c.778G>T	c.(778-780)GGT>TGT	p.G260C	NOVA1_uc001wpz.2_Missense_Mutation_p.G236C|NOVA1_uc001wqa.2_Missense_Mutation_p.G138C	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	263					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GCCACTGGACCTGTCACATTG	0.453			NA											10	109					5.16669e-11	8.46202e-11	0.000978	1	0
STRN3	29966	broad.mit.edu	37	14	31381009	31381009	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:31381009C>T	uc001wqu.2	-	12	1788	c.1572G>A	c.(1570-1572)GAG>GAA	p.E524E	STRN3_uc001wqv.2_Silent_p.E440E|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	524					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TGTAGATAGGCTCTACATCTA	0.338			NA											12	28					0	0	0.001368	0	0
PNN	5411	broad.mit.edu	37	14	39644500	39644500	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:39644500G>A	uc001wuw.3	+	1	114	c.17G>A	c.(16-18)AGA>AAA	p.R6K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	6	Potential.|Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GTCGCCGTGAGAACTTTGCAG	0.592			NA											3	9					0	0	0.004672	0	0
MIA2	117153	broad.mit.edu	37	14	39716500	39716500	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:39716500C>T	uc001wux.2	+	4	916	c.722C>T	c.(721-723)TCA>TTA	p.S241L	MIA2_uc010amy.1_Missense_Mutation_p.S172L	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	241						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GCTTTTGAATCAGTTATTGAA	0.418			NA											13	41					0	0	0.001368	0	0
LRFN5	145581	broad.mit.edu	37	14	42356411	42356411	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:42356411C>A	uc001wvm.2	+	3	1781	c.583C>A	c.(583-585)CAC>AAC	p.H195N	LRFN5_uc010ana.2_Missense_Mutation_p.H195N	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	195	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTCCCATTTGCACAAGATGAC	0.438			NA								HNSCC(30;0.082)			8	31					0.000157383	0.000191976	0.00308	1	0
RPL10L	140801	broad.mit.edu	37	14	47120508	47120508	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:47120508G>T	uc001wwg.2	-	1	521	c.432C>A	c.(430-432)AAC>AAA	p.N144K		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	144					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CATGCTCCTCGTTCTGAAGCT	0.522			NA											20	59					6.33239e-15	1.13392e-14	0.001523	1	0
NID2	22795	broad.mit.edu	37	14	52472512	52472512	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:52472512G>T	uc001wzo.2	-	21	4294	c.4060C>A	c.(4060-4062)CCA>ACA	p.P1354T	NID2_uc010tqs.1_Missense_Mutation_p.P1306T|NID2_uc010tqt.1_Missense_Mutation_p.P1354T	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1354	LDL-receptor class B 5.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CGTTGTTCTGGGAGATACTCA	0.423			NA											11	74					0.000673444	0.000798266	0.008291	1	0
NID2	22795	broad.mit.edu	37	14	52534799	52534799	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:52534799G>T	uc001wzo.2	-	2	545	c.311C>A	c.(310-312)CCG>CAG	p.P104Q	NID2_uc010tqs.1_Missense_Mutation_p.P104Q|NID2_uc010tqt.1_Missense_Mutation_p.P104Q|NID2_uc001wzp.2_Missense_Mutation_p.P104Q	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	104						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GGCGATGGCCGGGAAGTCGGT	0.642			NA											7	25					1.26484e-09	1.98445e-09	0.00308	1	0
TXNDC16	57544	broad.mit.edu	37	14	52936794	52936794	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:52936794C>A	uc001wzs.2	-	16	2028	c.1579G>T	c.(1579-1581)GTG>TTG	p.V527L	TXNDC16_uc010tqu.1_Missense_Mutation_p.V522L|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	527					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					AATACTGACACACTAGAATAC	0.343			NA											7	75					8.12818e-05	0.000101263	0.001984	1	0
EXOC5	10640	broad.mit.edu	37	14	57699436	57699436	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:57699436C>A	uc001xct.2	-	10	1138	c.887G>T	c.(886-888)AGG>ATG	p.R296M	EXOC5_uc001xcs.2_5'Flank|EXOC5_uc010trg.1_Missense_Mutation_p.R241M|EXOC5_uc010trh.1_Missense_Mutation_p.R231M	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	296					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						ATCGGACTTCCTACATTCTTC	0.254			NA											14	35					2.48551e-13	4.31828e-13	0.00499	1	0
SYNE2	23224	broad.mit.edu	37	14	64537540	64537540	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:64537540A>T	uc001xgm.2	+	52	10839	c.10609A>T	c.(10609-10611)AGT>TGT	p.S3537C	SYNE2_uc001xgl.2_Missense_Mutation_p.S3537C|SYNE2_uc010apw.1_Missense_Mutation_p.S243C	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3537	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GCGCATCAGAAGTATCCAGAA	0.428			NA											12	39					0	0	0.000978	0	0
SYNE2	23224	broad.mit.edu	37	14	64564793	64564793	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:64564793G>A	uc001xgm.2	+	62	12465	c.12235G>A	c.(12235-12237)GAA>AAA	p.E4079K	SYNE2_uc001xgl.2_Missense_Mutation_p.E4079K|SYNE2_uc010apy.2_Missense_Mutation_p.E464K|SYNE2_uc010apx.1_Missense_Mutation_p.E471K|MIR548H-1_hsa-mir-548h-1|MI0006411_5'Flank|SYNE2_uc010apz.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4079	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGAAGGAGTAGAAAGAGATAG	0.483			NA											5	77					0	0	0.001984	0	0
FUT8	2530	broad.mit.edu	37	14	66028258	66028258	+	Translation_Start_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:66028258G>T	uc001xin.2	+	3	1174	c.-23G>T	c.(-25--21)CAGGG>CATGG		FUT8_uc001xio.2_Translation_Start_Site|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Translation_Start_Site|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a						in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CAGGACTCCAGGGAAGTGAGT	0.428			NA											37	76					9.04072e-19	1.71493e-18	0.003271	1	0
Unknown	0	broad.mit.edu	37	14	66479778	66479778	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:66479778C>T	uc001xit.2	-	1	855	c.730G>A	c.(730-732)GGC>AGC	p.G244S						SubName: Full=Nuclease sensitive element binding protein-1;												NA						AGAGGAGGGCCTCTGCGGAAT	0.522			NA											12	49					0	0	0.000978	0	0
ADAM21	8747	broad.mit.edu	37	14	70925550	70925550	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:70925550C>T	uc001xmd.2	+	1	1334	c.1334C>T	c.(1333-1335)GCC>GTC	p.A445V		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	445	Disintegrin.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCTGGGGCTGCCTGTGCTTTT	0.498			NA											27	46					0	0	0.005443	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72196853	72196853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:72196853G>T	uc001xms.2	+	18	5107	c.4759G>T	c.(4759-4761)GAG>TAG	p.E1587*	SIPA1L1_uc001xmt.2_Nonsense_Mutation_p.E1566*|SIPA1L1_uc001xmu.2_Nonsense_Mutation_p.E1566*|SIPA1L1_uc001xmv.2_Nonsense_Mutation_p.E1587*|SIPA1L1_uc010ttm.1_Nonsense_Mutation_p.E1041*|SIPA1L1_uc001xmw.2_Nonsense_Mutation_p.E352*	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1587					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACTGTCGGACGAGAGCATTTA	0.567			NA											9	58					1.12685e-05	1.48953e-05	0.004482	1	0
ZFYVE1	53349	broad.mit.edu	37	14	73464728	73464728	+	Nonsense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:73464728G>C	uc001xnm.2	-	3	1419	c.779C>G	c.(778-780)TCA>TGA	p.S260*	ZFYVE1_uc010arj.2_Nonsense_Mutation_p.S260*	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	260						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		GACGAGGTCTGAGATGGCCAG	0.527			NA											3	42					0	0	0.004672	0	0
NGB	58157	broad.mit.edu	37	14	77734877	77734877	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:77734877G>T	uc001xtg.1	-	3	628	c.253C>A	c.(253-255)CTG>ATG	p.L85M		NM_021257	NP_067080	Q9NPG2	NGB_HUMAN	neuroglobin	85	Globin.					hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0273)		TACTCCTCCAGTGAGGACAGG	0.587			NA											15	81					2.23348e-06	3.05455e-06	0.004007	1	0
NRXN3	9369	broad.mit.edu	37	14	79434582	79434582	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:79434582G>T	uc001xun.2	+	11	2407	c.1916G>T	c.(1915-1917)CGA>CTA	p.R639L	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.R764L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1012	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTGGCCTCTCGAGATGGCTTT	0.522			NA											15	51					6.31663e-08	9.24099e-08	0.003163	1	0
C14orf145	145508	broad.mit.edu	37	14	81259284	81259284	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:81259284C>G	uc001xux.2	-	13	1551	c.1380G>C	c.(1378-1380)CGG>CGC	p.R460R	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	460	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		CACTGAGGTACCGCTCAGCCT	0.537			NA											8	75					0	0	0.004482	0	0
GALC	2581	broad.mit.edu	37	14	88442730	88442730	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:88442730C>A	uc001xvt.2	-	7	1123	c.724G>T	c.(724-726)GAA>TAA	p.E242*	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Nonsense_Mutation_p.E216*|GALC_uc010tvy.1_Nonsense_Mutation_p.E219*|GALC_uc010tvz.1_Nonsense_Mutation_p.E186*|GALC_uc001xvu.1_Nonsense_Mutation_p.E242*	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	242					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TTGAAGAGTTCGGCATCAAGG	0.398			NA											5	46					0.00116845	0.00137772	0.001168	1	0
ZC3H14	79882	broad.mit.edu	37	14	89068290	89068290	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:89068290G>C	uc001xww.2	+	11	1602	c.1377G>C	c.(1375-1377)ATG>ATC	p.M459I	ZC3H14_uc010twd.1_Missense_Mutation_p.M459I|ZC3H14_uc010twe.1_Missense_Mutation_p.M459I|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Missense_Mutation_p.M4I|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	459						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGGAATCCATGGTCCATGCAG	0.388			NA											9	66					0	0	0.004482	0	0
TTC8	123016	broad.mit.edu	37	14	89338020	89338020	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:89338020G>A	uc010ath.2	+	12	1359	c.1225G>A	c.(1225-1227)GAA>AAA	p.E409K	TTC8_uc001xxl.2_Missense_Mutation_p.E154K|TTC8_uc010ati.2_Missense_Mutation_p.E195K|TTC8_uc001xxm.2_Missense_Mutation_p.E353K|TTC8_uc010atj.2_Missense_Mutation_p.E128K|TTC8_uc001xxi.2_Missense_Mutation_p.E393K|TTC8_uc001xxj.2_Missense_Mutation_p.E383K|TTC8_uc001xxk.2_Missense_Mutation_p.E353K	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	419	TPR 6.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GGCTGAAAATGAAGAAGAGGC	0.413			NA							Bardet-Biedl_syndrome				5	101					0	0	0.001168	0	0
KCNK13	56659	broad.mit.edu	37	14	90650636	90650636	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:90650636C>T	uc001xye.1	+	2	958	c.516C>T	c.(514-516)CCC>CCT	p.P172P		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	172	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				GGGCCCTGCCCCAGGAGAGCC	0.612			NA											21	70					0	0	0.001882	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91338578	91338578	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:91338578C>A	uc001xys.2	-	17	2464	c.2249G>T	c.(2248-2250)AGC>ATC	p.S750I	RPS6KA5_uc010twi.1_Missense_Mutation_p.S671I	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	750					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GGTACTGGTGCTAGTCTTTTT	0.488			NA											9	49					9.70103e-10	1.53276e-09	0.008291	1	0
MOAP1	64112	broad.mit.edu	37	14	93650126	93650126	+	Missense_Mutation	SNP	C	C	A	rs148364724		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:93650126C>A	uc001ybj.2	-	3	832	c.462G>T	c.(460-462)CAG>CAT	p.Q154H	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	154					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		gcagggcaggctgaagagcct	0			NA											27	87					3.67414e-24	7.19296e-24	0.002445	1	0
SERPINA10	51156	broad.mit.edu	37	14	94756466	94756466	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:94756466G>T	uc001yct.2	-	2	931	c.465C>A	c.(463-465)AAC>AAA	p.N155K	SERPINA10_uc001ycu.3_Missense_Mutation_p.N155K	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	155					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		CCAGTTCCAGGTTGCGGGAGA	0.522			NA											8	70					0.000442599	0.000529778	0.006214	1	0
C14orf49	161176	broad.mit.edu	37	14	95932342	95932342	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:95932342C>A	uc001yei.3	-	3	568	c.553G>T	c.(553-555)GGG>TGG	p.G185W	C14orf49_uc010avi.2_Missense_Mutation_p.G185W|C14orf49_uc001yej.1_Missense_Mutation_p.G185W	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	185	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTGGGGTCCCCGATCCTGTTG	0.632			NA											13	39					4.3838e-07	6.19079e-07	0.001855	1	0
DIO3	1735	broad.mit.edu	37	14	102028467	102028467	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:102028467T>A	uc010txq.1	+	2	780	c.556T>A	c.(556-558)TCT>ACT	p.S186T	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	186	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				CACCACGGACTCTCCCTACAT	0.647			NA											19	59					0	0	0.001216	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409642	105409642	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:105409642C>T	uc010axc.1	-	7	12266	c.12146G>A	c.(12145-12147)GGG>GAG	p.G4049E	AHNAK2_uc001ypx.2_Missense_Mutation_p.G3949E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4049						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCAGGTGCCCTTTGAGGCT	0.627			NA											5	197					0	0	0.000602	0	0
MTA1	9112	broad.mit.edu	37	14	105911775	105911775	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:105911775G>T	uc001yqx.2	+	3	304	c.117G>T	c.(115-117)GAG>GAT	p.E39D	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Translation_Start_Site|MTA1_uc001yra.1_Translation_Start_Site	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	39	BAH.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GGAACGTGGAGGCCAAAGTGG	0.657			NA											7	48					0.00198382	0.00231877	0.001984	1	0
MTA1	9112	broad.mit.edu	37	14	105924709	105924709	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:105924709G>T	uc001yqx.2	+	8	840	c.653G>T	c.(652-654)CGC>CTC	p.R218L	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Missense_Mutation_p.R132L|MTA1_uc001yra.1_Missense_Mutation_p.R132L|MTA1_uc001yrb.2_5'UTR	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	218	ELM2.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GTGGTGGCCCGGTGAGTCCTG	0.632			NA											6	23					0.00198382	0.00231877	0.001984	1	0
Unknown	0	broad.mit.edu	37	15	20658886	20658886	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:20658886C>T	uc001ytg.2	-	14	2000	c.1291G>A	c.(1291-1293)GGA>AGA	p.G431R	uc010tyx.1_Intron|uc001yth.3_Missense_Mutation_p.G431R|uc010tyy.1_Missense_Mutation_p.G431R|uc010tyz.1_Missense_Mutation_p.G279R					RecName: Full=Putative HERC2-like protein 3;												NA						ATATCGATTCCCTCAGGAATA	0.363			NA											7	106					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	15	22440467	22440467	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:22440467G>T	uc001yug.2	-	1	399	c.380C>A	c.(379-381)GCC>GAC	p.A127D						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						AGTCAGCTTGGCTCCCTTCTT	0.453			NA											8	29					0.00621372	0.00712032	0.006214	1	0
Unknown	0	broad.mit.edu	37	15	22440669	22440669	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:22440669G>T	uc001yug.2	-	1	197	c.178C>A	c.(178-180)CTG>ATG	p.L60M						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						CTCACGTCCAGCCTCAGGGCA	0.527			NA											4	50					0.00024832	0.000301804	0.000248	1	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938316	30938316	+	Splice_Site	SNP	G	G	A	rs112615235	by1000genomes	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:30938316G>A	uc010azv.1	+	11		c.1127_splice	c.e11-1		ARHGAP11B_uc001zeu.2_Splice_Site			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		TTCCTTGGCAGTGGATAAGTT	0.393			NA											5	26					0	0	0.000602	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298308	42298308	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:42298308C>A	uc001zow.1	-	3	318	c.318G>T	c.(316-318)GAG>GAT	p.E106D		NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	117	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AGACACTCAACTCTAGCACGT	0.512			NA											10	28					4.68919e-08	6.92803e-08	0.008291	1	0
GANC	2595	broad.mit.edu	37	15	42600445	42600445	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:42600445C>G	uc001zpi.2	+	8	965	c.651C>G	c.(649-651)TTC>TTG	p.F217L	GANC_uc001zph.2_Missense_Mutation_p.F217L|GANC_uc001zpj.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	217					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GTTTGGATTTCTCCTTGCATG	0.393			NA											27	112					0	0	0.001786	0	0
TP53BP1	7158	broad.mit.edu	37	15	43724817	43724817	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:43724817C>A	uc001zrs.2	-	17	3383	c.3235G>T	c.(3235-3237)GGT>TGT	p.G1079C	TP53BP1_uc010udp.1_Missense_Mutation_p.G1079C|TP53BP1_uc001zrq.3_Missense_Mutation_p.G1084C|TP53BP1_uc001zrr.3_Missense_Mutation_p.G1084C|TP53BP1_uc010udq.1_Missense_Mutation_p.G1084C	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1079					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTATGGTCACCCTCCAATTTT	0.453			NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					8	25					0.000274275	0.000331549	0.004482	1	0
B2M	567	broad.mit.edu	37	15	45007761	45007761	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:45007761G>T	uc001zuc.2	+	2	268	c.208G>T	c.(208-210)GAG>TAG	p.E70*	B2M_uc010uek.1_Nonsense_Mutation_p.E70*|B2M_uc010bdx.1_Intron	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	70	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TGAAAAAGTGGAGCATTCAGA	0.413			NA											9	46					0.00448238	0.00518058	0.004482	1	0
CEP152	22995	broad.mit.edu	37	15	49044594	49044594	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:49044594C>A	uc001zwy.2	-	21	3452	c.3418G>T	c.(3418-3420)GGA>TGA	p.G1140*	CEP152_uc001zwz.2_Nonsense_Mutation_p.G1140*|CEP152_uc001zxa.1_Nonsense_Mutation_p.G1047*	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1140					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GCATGGTGTCCAGCAGCAGGT	0.458			NA											25	111					3.28513e-13	5.70016e-13	0.003954	1	0
KIAA1370	56204	broad.mit.edu	37	15	52877008	52877008	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:52877008C>G	uc002acg.3	-	12	3164	c.3011G>C	c.(3010-3012)AGA>ACA	p.R1004T	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.R916T|KIAA1370_uc002acf.3_Missense_Mutation_p.R34T|KIAA1370_uc010ugf.1_Missense_Mutation_p.R1011T	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	1004											0				all cancers(107;0.0803)		ATTAACACTTCTCTTCACTTC	0.343			NA											6	28					0	0	0.00308	0	0
UNC13C	440279	broad.mit.edu	37	15	54685257	54685257	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:54685257G>T	uc002ack.2	+	16	4725	c.4725G>T	c.(4723-4725)CAG>CAT	p.Q1575H	UNC13C_uc002acl.2_Missense_Mutation_p.Q405H	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1575					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTAAGAAACAGGATATTCCTC	0.373			NA											16	75					5.03518e-11	8.26681e-11	0.007413	1	0
HERC1	8925	broad.mit.edu	37	15	63955365	63955365	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:63955365T>A	uc002amp.2	-	44	8867	c.8719A>T	c.(8719-8721)AGT>TGT	p.S2907C		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2907					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCTCTCCGACTTTGATTCCTG	0.408			NA											57	140					0	0	0.00361	0	0
SNX1	6642	broad.mit.edu	37	15	64426924	64426924	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:64426924A>T	uc002amv.2	+	12	1319	c.1283A>T	c.(1282-1284)CAG>CTG	p.Q428L	SNX1_uc010bgv.2_Missense_Mutation_p.Q142L|SNX1_uc010uio.1_Missense_Mutation_p.Q428L|SNX1_uc002amw.2_Intron|SNX1_uc002amx.2_Missense_Mutation_p.Q363L|SNX1_uc002amy.2_Missense_Mutation_p.Q357L|SNX1_uc010bgw.2_Missense_Mutation_p.Q330L	NM_003099	NP_003090	Q13596	SNX1_HUMAN	sorting nexin 1 isoform a	428	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0						GCCACACTGCAGAAGAAGCGG	0.627			NA											9	32					0	0	0.004482	0	0
RBPMS2	348093	broad.mit.edu	37	15	65041311	65041311	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:65041311C>A	uc002anq.2	-	5	558	c.306G>T	c.(304-306)AGG>AGT	p.R102S		NM_194272	NP_919248	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	102	RRM.						nucleic acid binding|nucleotide binding				0						CAAACTCTAGCCTCAGAGTCT	0.517			NA											16	85					3.52763e-06	4.77101e-06	0.00499	1	0
DPP8	54878	broad.mit.edu	37	15	65744362	65744362	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:65744362C>A	uc002aov.2	-	18	3976	c.2398G>T	c.(2398-2400)GAC>TAC	p.D800Y	DPP8_uc002aow.2_Missense_Mutation_p.D800Y|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.D784Y|DPP8_uc002aoy.2_Missense_Mutation_p.D749Y|DPP8_uc002aoz.2_Missense_Mutation_p.D684Y|DPP8_uc010bhj.2_Missense_Mutation_p.D800Y|DPP8_uc002apa.2_Missense_Mutation_p.D597Y|DPP8_uc010bhi.2_Missense_Mutation_p.D103Y|DPP8_uc010bhk.1_Missense_Mutation_p.D369Y	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	800				PDQNE -> LTRMN (in Ref. 6; AAQ13623).	immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						TCATTCTGGTCAGGGTGACCC	0.423			NA											41	128					5.44703e-19	1.0347e-18	0.002222	1	0
UACA	55075	broad.mit.edu	37	15	70991943	70991943	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:70991943C>A	uc002asr.2	-	2	239	c.135G>T	c.(133-135)GGG>GGT	p.G45G	UACA_uc010uke.1_Silent_p.G45G|UACA_uc002asq.2_Silent_p.G32G|UACA_uc010bin.1_Silent_p.G31G	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	45	ANK 1.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TTTCTACATCCCCCCTTTCTG	0.373			NA											14	82					1.49906e-05	1.9584e-05	0.00245	1	0
LRRC49	54839	broad.mit.edu	37	15	71329670	71329670	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:71329670A>G	uc002asw.2	+	15	2103	c.1856A>G	c.(1855-1857)GAG>GGG	p.E619G	LRRC49_uc002asu.2_Missense_Mutation_p.E609G|LRRC49_uc002asx.2_Missense_Mutation_p.E575G|LRRC49_uc010ukf.1_Missense_Mutation_p.E624G|LRRC49_uc002asy.2_Missense_Mutation_p.E325G|LRRC49_uc002asz.2_Missense_Mutation_p.E591G	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	619						cytoplasm|microtubule				ovary(1)	1						GAAAAGCTAGAGGTAAAACTA	0.333			NA											24	91					0	0	0.003954	0	0
HEXA	3073	broad.mit.edu	37	15	72648940	72648940	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:72648940T>C	uc002aun.3	-	2	479	c.272A>G	c.(271-273)GAG>GGG	p.E91G	CELF6_uc002auk.3_RNA|HEXA_uc010ukn.1_Missense_Mutation_p.E102G|HEXA_uc002auo.3_5'UTR|HEXA_uc010bix.2_Missense_Mutation_p.E91G|HEXA_uc010biy.2_5'UTR|HEXA_uc010uko.1_5'UTR|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	91					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						CACATTCTTCTCCAGTGTATG	0.493			NA											23	39					0	0	0.00333	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954782	72954782	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:72954782T>A	uc010uks.1	+	11	1078	c.1037T>A	c.(1036-1038)CTC>CAC	p.L346H		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	346	Potential.										0						GAGGAGATGCTCCGAGAGCAG	0.562			NA											77	359					0	0	0.00361	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703307	74703307	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:74703307C>G	uc002axv.2	-	14	1699	c.1659G>C	c.(1657-1659)AAG>AAC	p.K553N	SEMA7A_uc010ulk.1_Missense_Mutation_p.K388N|SEMA7A_uc010ull.1_Missense_Mutation_p.K539N	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	553	Ig-like C2-type.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						CCAGGGAAACCTTCTGCAGTG	0.627			NA											10	81					0	0	0.008291	0	0
CSPG4	1464	broad.mit.edu	37	15	75980924	75980924	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:75980924C>G	uc002baw.2	-	3	2575	c.2482G>C	c.(2482-2484)GCT>CCT	p.A828P		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	828	CSPG 4.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TTCCTGGGAGCCTGAACCACC	0.617			NA											11	69					0	0	0.001368	0	0
ACSBG1	23205	broad.mit.edu	37	15	78486874	78486874	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:78486874G>T	uc002bdh.2	-	3	483	c.427C>A	c.(427-429)CGC>AGC	p.R143S	ACSBG1_uc010umw.1_Missense_Mutation_p.R143S|ACSBG1_uc010umx.1_Intron|ACSBG1_uc010umy.1_Missense_Mutation_p.R36S	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	143					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GCGGCTCTGCGGGCGAGCAGG	0.622			NA											7	32					0.00198382	0.00231877	0.001984	1	0
CHRNA5	1138	broad.mit.edu	37	15	78882859	78882859	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:78882859C>G	uc002bdy.2	+	5	1288	c.1126C>G	c.(1126-1128)CAG>GAG	p.Q376E	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	376	Cytoplasmic (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTACTTCACTCAGAAAGAGGA	0.438			NA											3	88					0	0	0.004672	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051871	79051871	+	Silent	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:79051871T>A	uc002bej.3	-	24	5164	c.4953A>T	c.(4951-4953)CTA>CTT	p.L1651L		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1651	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						AGCGGCCCAGTAGGCGCAGCG	0.706			NA											4	13					0	0	0.000248	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79090375	79090375	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:79090375C>G	uc002bej.3	-	3	748	c.537G>C	c.(535-537)CAG>CAC	p.Q179H	ADAMTS7_uc010und.1_Missense_Mutation_p.Q179H|ADAMTS7_uc002bek.1_Missense_Mutation_p.Q179H	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	179					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CCACATGGGGCTGGGCGTGGC	0.627			NA											16	46					0	0	0.004007	0	0
ARNT2	9915	broad.mit.edu	37	15	80767527	80767527	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:80767527G>T	uc002bfr.2	+	5	751	c.585G>T	c.(583-585)CTG>CTT	p.L195L	ARNT2_uc002bfq.2_Silent_p.L195L|ARNT2_uc010unm.1_Silent_p.L184L|ARNT2_uc002bfs.2_Silent_p.L184L	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	195	PAS 1.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGGAGAAGCTGAGAGAGCAAC	0.463			NA											19	56					2.94398e-08	4.37364e-08	0.007413	1	0
STARD5	80765	broad.mit.edu	37	15	81615245	81615245	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:81615245C>T	uc002bgm.2	-	2	228	c.144G>A	c.(142-144)GGG>GGA	p.G48G	STARD5_uc002bgn.2_Intron	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	48	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						CTTACAGGTTCCCTGGAAACT	0.378			NA											14	48					0	0	0.003163	0	0
CPEB1	64506	broad.mit.edu	37	15	83226674	83226674	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:83226674G>T	uc002bit.2	-	4	759	c.622C>A	c.(622-624)CCT>ACT	p.P208T	CPEB1_uc002biq.2_Missense_Mutation_p.P73T|CPEB1_uc002bir.2_Missense_Mutation_p.P73T|CPEB1_uc002bis.2_Missense_Mutation_p.P73T|CPEB1_uc010uod.1_Intron|CPEB1_uc010uoe.1_Missense_Mutation_p.P151T|CPEB1_uc002biu.2_Missense_Mutation_p.P175T|CPEB1_uc010uof.1_Missense_Mutation_p.P73T|CPEB1_uc002biv.2_Missense_Mutation_p.P148T|CPEB1_uc002bip.2_5'Flank	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	148					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGATCCAGAGGCAGGAAGCTC	0.532			NA											10	58					7.48243e-07	1.04676e-06	0.006214	1	0
NTRK3	4916	broad.mit.edu	37	15	88680741	88680741	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:88680741C>A	uc002bme.1	-	6	678	c.516G>T	c.(514-516)CAG>CAT	p.Q172H	NTRK3_uc002bmh.2_Missense_Mutation_p.Q172H|NTRK3_uc002bmf.1_Missense_Mutation_p.Q172H|NTRK3_uc010upl.1_Missense_Mutation_p.Q74H|NTRK3_uc010bnh.1_Missense_Mutation_p.Q172H|NTRK3_uc002bmg.2_Missense_Mutation_p.Q172H	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	172	Extracellular (Potential).|LRRCT.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTGCCAGAGCTGCATCCAGC	0.567			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			9	19					1.12685e-05	1.48953e-05	0.004482	1	0
FURIN	5045	broad.mit.edu	37	15	91423431	91423431	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:91423431A>G	uc002bpu.1	+	13	1700	c.1484A>G	c.(1483-1485)TAT>TGT	p.Y495C		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	495					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ACCCTGTCCTATAATCGCCGT	0.692			NA											4	22					0	0	0.000602	0	0
C15orf32	145858	broad.mit.edu	37	15	93015532	93015532	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:93015532T>A	uc002brc.1	+	1	626	c.154T>A	c.(154-156)TGG>AGG	p.W52R	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	52										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			GCCATGTGTCTGGACCCTGTG	0.423			NA											19	96					0	0	0.001216	0	0
FAM169B	283777	broad.mit.edu	37	15	98995109	98995109	+	Silent	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:98995109T>A	uc002buk.1	-	5	565	c.315A>T	c.(313-315)CCA>CCT	p.P105P		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	105											0						CCTCGTCCTCTGGGAATGTCT	0.562			NA											5	14					0	0	0.000602	0	0
IGF1R	3480	broad.mit.edu	37	15	99250831	99250831	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:99250831G>T	uc002bul.2	+	2	185	c.135G>T	c.(133-135)CAG>CAT	p.Q45H	IGF1R_uc010urq.1_Missense_Mutation_p.Q45H|IGF1R_uc010bon.2_Missense_Mutation_p.Q45H	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	45					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ACTATCAGCAGCTGAAGCGCC	0.527			NA											7	25					8.12818e-05	0.000101263	0.001984	1	0
LRRC28	123355	broad.mit.edu	37	15	99901651	99901651	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:99901651A>G	uc002bva.1	+	8	961	c.806A>G	c.(805-807)CAC>CGC	p.H269R	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.H115R|LRRC28_uc010urt.1_Missense_Mutation_p.H83R|LRRC28_uc002bvc.1_Missense_Mutation_p.H269R|LRRC28_uc010uru.1_Missense_Mutation_p.H200R|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	269											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			GAGCATGATCACGTCCTCCCT	0.507			NA									OREG0023509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	80					0	0	0.002096	0	0
LASS3	204219	broad.mit.edu	37	15	101024836	101024836	+	Missense_Mutation	SNP	G	G	C	rs138661052	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr15:101024836G>C	uc002bvz.2	-	6	828	c.326C>G	c.(325-327)ACG>AGG	p.T109R	LASS3_uc002bwa.2_Missense_Mutation_p.T120R|LASS3_uc002bwb.2_Missense_Mutation_p.T109R	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	109	Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			CTGGCGCTCCGTCAAGTTACA	0.478	NSCLC(135;1149 2482 10680 49908)		NA											9	18					0	0	0.004482	0	0
POLR3K	51728	broad.mit.edu	37	16	101609	101609	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:101609C>G	uc002cfi.1	-	2	187	c.148G>C	c.(148-150)GAT>CAT	p.D50H	SNRNP25_uc002cfj.3_5'Flank	NM_016310	NP_057394	Q9Y2Y1	RPC10_HUMAN	DNA directed RNA polymerase III polypeptide K	50					innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding				0		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				AGCACATCATCCACTTCTTTC	0.443			NA											5	50					0	0	0.000602	0	0
RHBDF1	64285	broad.mit.edu	37	16	111616	111616	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:111616G>A	uc002cfl.3	-	12	1435	c.1287C>T	c.(1285-1287)CCC>CCT	p.P429P	RHBDF1_uc010uty.1_Silent_p.P452P|RHBDF1_uc010utz.1_Silent_p.P429P|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	429	Helical; (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				AGAAGCCCACGGGCGCGATGC	0.667			NA											20	37					0	0	0.001523	0	0
MSLNL	401827	broad.mit.edu	37	16	830355	830355	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:830355G>A	uc002cjz.1	-	3	646	c.646C>T	c.(646-648)CAT>TAT	p.H216Y		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GGTGGAGCATGCACAGGCGTG	0.602			NA											9	23					0	0	0.004482	0	0
SSTR5	6755	broad.mit.edu	37	16	1129561	1129561	+	Silent	SNP	G	G	A	rs35804776	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:1129561G>A	uc002ckq.2	+	1	781	c.693G>A	c.(691-693)GCG>GCA	p.A231A	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	231	Cytoplasmic (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TGAGGGCGGCGGGCGTGCGCG	0.667			NA											9	20					0	0	0.004482	0	0
C16orf91	283951	broad.mit.edu	37	16	1479269	1479269	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:1479269G>T	uc010uvd.1	-	1	77	c.77C>A	c.(76-78)TCG>TAG	p.S26*		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	Error:Variant_position_missing_in_Q4G0I0_after_alignment						integral to membrane					0						TGGCTGTGCCGATGCTGTCCC	0.657			NA											8	113					0.00307968	0.00357786	0.00308	1	0
ZSCAN10	84891	broad.mit.edu	37	16	3142715	3142715	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:3142715G>T	uc002ctv.1	-	1	147	c.59C>A	c.(58-60)CCG>CAG	p.P20Q	ZSCAN10_uc002cty.1_Intron|ZSCAN10_uc002ctw.1_Silent_p.A27A|ZSCAN10_uc002ctx.1_5'UTR	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	20	SCAN box.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GTGCAGAGCCGGCCGCAGCCA	0.672			NA											6	18					0.00198382	0.00231877	0.001984	1	0
BTBD12	84464	broad.mit.edu	37	16	3639743	3639743	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:3639743C>A	uc002cvp.2	-	12	4523	c.3896G>T	c.(3895-3897)AGG>ATG	p.R1299M		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1299	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GTTCCCTTCCCTGTTTCCTAC	0.612			NA						Direct_reversal_of_damage|Homologous_recombination	FanconAnemia				14	103					6.31663e-08	9.24099e-08	0.003163	1	0
GLIS2	84662	broad.mit.edu	37	16	4385127	4385127	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:4385127G>A	uc002cwc.1	+	4	646	c.589G>A	c.(589-591)GAG>AAG	p.E197K		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	197					cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						TGTCAAGCCCGAGAAGGATGC	0.612			NA											9	55					0	0	0.004482	0	0
ANKS3	124401	broad.mit.edu	37	16	4747383	4747383	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:4747383C>G	uc002cxj.1	-	16	2140	c.1845G>C	c.(1843-1845)ATG>ATC	p.M615I	ANKS3_uc010uxr.1_Missense_Mutation_p.M138I|ANKS3_uc002cxh.1_RNA|ANKS3_uc002cxi.1_Missense_Mutation_p.M542I|ANKS3_uc002cxk.2_Missense_Mutation_p.M486I|ANKS3_uc002cxl.2_Missense_Mutation_p.M442I|ANKS3_uc010uxs.1_Missense_Mutation_p.M542I	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	615											0						CGGGGAGGCTCATGGCCTGCA	0.642			NA											5	56					0	0	0.001168	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858247	9858247	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:9858247G>T	uc002czo.3	-	13	3702	c.3154C>A	c.(3154-3156)CTT>ATT	p.L1052I	GRIN2A_uc010uym.1_Missense_Mutation_p.L1052I|GRIN2A_uc010uyn.1_Missense_Mutation_p.L895I|GRIN2A_uc002czr.3_Missense_Mutation_p.L1052I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1052	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTTCTGGAAGATACCTAGGG	0.507			NA											50	112					7.05377e-20	1.35332e-19	0.00361	1	0
MKL2	57496	broad.mit.edu	37	16	14355224	14355224	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:14355224C>G	uc010uza.1	+	17	3378	c.3223C>G	c.(3223-3225)CCT>GCT	p.P1075A	MKL2_uc002dcg.2_Missense_Mutation_p.P1025A|MKL2_uc002dcj.2_Missense_Mutation_p.P320A	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	1064					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						AGGACTCACTCCTCTCAGCAC	0.527			NA											4	41					0	0	0.000248	0	0
GPR139	124274	broad.mit.edu	37	16	20043246	20043247	+	Missense_Mutation	DNP	CC	CC	AA	rs144836581		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:20043246_20043247CC>AA	uc002dgu.1	-	2	1034_1035	c.872_873GG>TT	c.(871-873)CGG>CTT	p.R291L	GPR139_uc010vaw.1_Missense_Mutation_p.R198L	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	291	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						TGGTGCGGAACCGCTTGCTGAT	0.505			NA											28	84					0	0	0.004672	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565129	20565129	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:20565129C>A	uc002dhj.3	-	6	920	c.710G>T	c.(709-711)AGC>ATC	p.S237I	ACSM2B_uc002dhk.3_Missense_Mutation_p.S237I|ACSM2B_uc010bwf.1_Missense_Mutation_p.S237I	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	237					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GAGGCCCAGGCTCGAGTAGGA	0.507			NA											6	72					1.12685e-05	1.48953e-05	0.004482	1	0
ANKS4B	257629	broad.mit.edu	37	16	21261469	21261469	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:21261469C>A	uc010bwp.1	+	2	625	c.582C>A	c.(580-582)TTC>TTA	p.F194L	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	194										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CTGGCACATTCGGGTCACTAT	0.493			NA											20	55					1.87028e-06	2.58414e-06	0.001882	1	0
OTOA	146183	broad.mit.edu	37	16	21730494	21730494	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:21730494G>T	uc002djh.2	+	15	1671	c.1670G>T	c.(1669-1671)AGG>ATG	p.R557M	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.R478M|OTOA_uc002dji.2_Missense_Mutation_p.R233M|OTOA_uc010vbk.1_Missense_Mutation_p.R205M	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	571					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		ACCACCAGAAGGCCTGAGGAG	0.527			NA											16	47					1.37522e-17	2.56874e-17	0.007413	1	0
POLR3E	55718	broad.mit.edu	37	16	22326444	22326444	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:22326444G>T	uc002dkk.2	+	9	713	c.557G>T	c.(556-558)CGC>CTC	p.R186L	POLR3E_uc002dkj.1_Missense_Mutation_p.R186L|POLR3E_uc002dkm.2_Missense_Mutation_p.R150L|POLR3E_uc010vbr.1_Missense_Mutation_p.R186L|POLR3E_uc002dkl.2_Missense_Mutation_p.R186L|POLR3E_uc010vbs.1_Missense_Mutation_p.R150L|POLR3E_uc010vbt.1_Missense_Mutation_p.R130L	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	186					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		GAGCAGGCCCGCCAGCGCCGT	0.647			NA											5	12					3.59834e-05	4.57629e-05	0.001168	1	0
TAOK2	9344	broad.mit.edu	37	16	29997020	29997020	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:29997020C>T	uc002dva.1	+	15	2613	c.1830C>T	c.(1828-1830)GCC>GCT	p.A610A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Silent_p.A610A|TAOK2_uc002dvc.1_Silent_p.A610A|TAOK2_uc010bzm.1_Silent_p.A617A|TAOK2_uc002dvd.1_Silent_p.A437A	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	610					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GGGAGAAGGCCGAGTGGCTGC	0.682			NA											3	13					0	0	0.000248	0	0
SEPT1	1731	broad.mit.edu	37	16	30389945	30389945	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:30389945C>G	uc002dxy.2	-	11	1190	c.1003G>C	c.(1003-1005)GAG>CAG	p.E335Q	SEPT1_uc002dxw.2_RNA|SEPT1_uc002dxx.2_Missense_Mutation_p.E160Q	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	335					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TCGTCTTTCTCGCGGATCAGC	0.657			NA											4	17					0	0	0.000602	0	0
ITGAM	3684	broad.mit.edu	37	16	31339510	31339510	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:31339510G>T	uc002ebq.2	+	23	2849	c.2751G>T	c.(2749-2751)CTG>CTT	p.L917L	ITGAM_uc002ebr.2_Silent_p.L918L|ITGAM_uc010can.2_Silent_p.L323L	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	917	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						AATTCCAACTGGAGCTGCCGG	0.488			NA											25	61					8.24728e-16	1.49073e-15	0.004656	1	0
ITGAX	3687	broad.mit.edu	37	16	31391338	31391338	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:31391338A>T	uc002ebu.1	+	26	3079	c.3012A>T	c.(3010-3012)GCA>GCT	p.A1004A	ITGAX_uc002ebt.2_Silent_p.A1004A	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1004	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGAAAATCGCACCCCCAGCAT	0.577			NA											4	37					0	0	0.000602	0	0
C16orf78	123970	broad.mit.edu	37	16	49433132	49433132	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:49433132C>A	uc002efr.2	+	5	784	c.741C>A	c.(739-741)GTC>GTA	p.V247V		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	247										central_nervous_system(1)	1						CCCACATGGTCGAAGAGGACA	0.498			NA											12	38					2.27111e-07	3.25171e-07	0.001368	1	0
RBL2	5934	broad.mit.edu	37	16	53501044	53501044	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:53501044G>T	uc002ehi.3	+	14	2056	c.1938G>T	c.(1936-1938)GTG>GTT	p.V646V	RBL2_uc010vgv.1_Silent_p.V572V|RBL2_uc002ehj.2_Silent_p.V356V|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	646	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCAGAAGGGTGACTGAAGTTC	0.418			NA											9	100					2.17888e-05	2.81911e-05	0.006214	1	0
GPR56	9289	broad.mit.edu	37	16	57689862	57689862	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:57689862C>G	uc002emb.2	+	8	1267	c.975C>G	c.(973-975)CTC>CTG	p.L325L	GPR56_uc002elz.1_Silent_p.L155L|GPR56_uc002ema.1_Silent_p.L150L|GPR56_uc002emc.2_Silent_p.L325L|GPR56_uc002emf.2_Silent_p.L325L|GPR56_uc010vhs.1_Silent_p.L325L|GPR56_uc002emd.2_Silent_p.L325L|GPR56_uc002eme.2_Silent_p.L325L|GPR56_uc010vht.1_Silent_p.L330L|GPR56_uc002emg.3_Silent_p.L325L|GPR56_uc010vhu.1_Silent_p.L150L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	325	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						TAGCCAACCTCACGGAGCCCG	0.567			NA											4	108					0	0	0.000248	0	0
MMP15	4324	broad.mit.edu	37	16	58073844	58073844	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:58073844G>A	uc002ena.2	+	4	1479	c.506G>A	c.(505-507)CGC>CAC	p.R169H		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	169	Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						AGGGCCTTCCGCGTGTGGGAG	0.637			NA											10	20					0	0	0.008291	0	0
FHOD1	29109	broad.mit.edu	37	16	67264340	67264340	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:67264340G>C	uc002esl.2	-	19	3040	c.2928C>G	c.(2926-2928)TTC>TTG	p.F976L	FHOD1_uc002esk.2_Missense_Mutation_p.F35L|FHOD1_uc010ced.2_Missense_Mutation_p.F783L	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	976	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GCGTGTGGCAGAACTGCATGA	0.592			NA											6	51					0	0	0.001168	0	0
NFATC3	4775	broad.mit.edu	37	16	68156673	68156673	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:68156673C>T	uc002evo.1	+	2	1097	c.887C>T	c.(886-888)TCA>TTA	p.S296L	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.S296L|NFATC3_uc002evm.1_Missense_Mutation_p.S296L|NFATC3_uc002evn.1_Missense_Mutation_p.S296L|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	296	3 X SP repeats.|3.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CCTGTTCCTTCACCTGGTCAC	0.557			NA											24	43					0	0	0.005443	0	0
PDPR	55066	broad.mit.edu	37	16	70170214	70170214	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:70170214C>T	uc002eyf.1	+	10	2072	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.S272F|PDPR_uc002eyg.1_Missense_Mutation_p.S100F	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	372					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		ATGGGCGAGTCTCCTGCAGTG	0.512			NA											5	39					0	0	0.001984	0	0
WDR59	79726	broad.mit.edu	37	16	74927676	74927676	+	Nonsense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:74927676G>C	uc002fdh.1	-	19	2003	c.1901C>G	c.(1900-1902)TCA>TGA	p.S634*	WDR59_uc002fdf.1_Nonsense_Mutation_p.S79*|WDR59_uc002fdg.1_Nonsense_Mutation_p.S226*	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	634										ovary(1)|breast(1)	2						GCCAGAGTCTGATCCCTCACG	0.478			NA											3	74					0	0	0.000248	0	0
CHST5	23563	broad.mit.edu	37	16	75563281	75563281	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr16:75563281G>A	uc002fei.2	-	3	2397	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I	CHST5_uc002fej.1_Silent_p.I340I	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	334	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TTGGCTTGCCGATCCCCGACC	0.642			NA											15	50					0	0	0.003163	0	0
SMG6	23293	broad.mit.edu	37	17	2203274	2203274	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:2203274C>A	uc002fub.1	-	2	828	c.773G>T	c.(772-774)AGC>ATC	p.S258I	SMG6_uc002fud.1_Missense_Mutation_p.S227I	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	258	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						TGAGCTGGTGCTGCGCGTGCG	0.657	Melanoma(59;28 1088 11621 25887 46638 50814)		NA											14	28					9.05144e-12	1.51572e-11	0.001855	1	0
OR1E1	8387	broad.mit.edu	37	17	3300867	3300867	+	Missense_Mutation	SNP	C	C	T	rs144219652	by1000genomes	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:3300867C>T	uc002fvj.1	-	1	838	c.838G>A	c.(838-840)GTG>ATG	p.V280M		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGGGTCACCACAGTGTACATC	0.458			NA											18	58					0	0	0.007413	0	0
P2RX1	5023	broad.mit.edu	37	17	3819461	3819461	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:3819461C>G	uc002fww.2	-	1	500	c.59G>C	c.(58-60)CGC>CCC	p.R20P	P2RX1_uc010ckm.1_5'UTR	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	20	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CAGCACCATGCGGGGGGTGTC	0.652			NA											38	70					0	0	0.007835	0	0
RPAIN	84268	broad.mit.edu	37	17	5335888	5335888	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:5335888C>G	uc002gbq.2	+	7	1227	c.657C>G	c.(655-657)CTC>CTG	p.L219L	RPAIN_uc010vtb.1_3'UTR|RPAIN_uc002gbs.2_Silent_p.L235L|RPAIN_uc002gbt.2_Silent_p.L172L|RPAIN_uc002gbu.2_Silent_p.L188L|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_3'UTR	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	219					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						CTGTGATCCTCTAGAGCCAGC	0.368			NA											4	58					0	0	0.000248	0	0
AIPL1	23746	broad.mit.edu	37	17	6330023	6330023	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:6330023C>A	uc002gcp.2	-	5	791	c.696G>T	c.(694-696)CTG>CTT	p.L232L	AIPL1_uc002gcq.2_Silent_p.L172L|AIPL1_uc002gcr.2_Silent_p.L169L|AIPL1_uc010clk.2_Silent_p.L210L|AIPL1_uc010cll.2_Intron|AIPL1_uc002gcs.2_Silent_p.L232L	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	232	TPR 2.				protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		AGTTGAGGATCAGAGTATTGA	0.582			NA											10	20					3.86212e-05	4.87942e-05	0.008291	1	0
PITPNM3	83394	broad.mit.edu	37	17	6358908	6358908	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:6358908G>A	uc002gdd.3	-	20	2826	c.2675C>T	c.(2674-2676)TCA>TTA	p.S892L	PITPNM3_uc010cln.2_Missense_Mutation_p.S856L|PITPNM3_uc010clm.2_Missense_Mutation_p.S375L|PITPNM3_uc002gdc.3_Missense_Mutation_p.S483L	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	892					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CTTTGGGCGTGAGCGGTGGCT	0.532			NA											6	27					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7577507	7577507	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:7577507T>A	uc002gim.2	-	7	968	c.774A>T	c.(772-774)GAA>GAT	p.E258D	TP53_uc002gig.1_Missense_Mutation_p.E258D|TP53_uc002gih.2_Missense_Mutation_p.E258D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E126D|TP53_uc010cng.1_Missense_Mutation_p.E126D|TP53_uc002gii.1_Missense_Mutation_p.E126D|TP53_uc010cnh.1_Missense_Mutation_p.E258D|TP53_uc010cni.1_Missense_Mutation_p.E258D|TP53_uc002gij.2_Missense_Mutation_p.E258D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E165D|TP53_uc002gio.2_Missense_Mutation_p.E126D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	258	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> Q (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E258K(37)|p.E258*(12)|p.E258Q(8)|p.E258D(8)|p.0?(7)|p.E258G(7)|p.E258V(5)|p.E258A(5)|p.D259fs*5(1)|p.?(1)|p.E258fs*85(1)|p.E258>XX(1)|p.E258fs*71(1)|p.D259fs*86(1)|p.E258fs*2(1)|p.E258_S260delEDS(1)|p.E258del(1)|p.E258L(1)|p.E258fs*87(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCTGGAGTCTTCCAGTGTGA	0.577	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	21					0	0	0.006122	0	0
PER1	5187	broad.mit.edu	37	17	8050243	8050243	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:8050243G>A	uc002gkd.2	-	14	1945	c.1707C>T	c.(1705-1707)GCC>GCT	p.A569A	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.A553A	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	569					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						ACTGAGGCCGGGCCCGAGACT	0.587			NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					52	95					0	0	0.00361	0	0
MYH13	8735	broad.mit.edu	37	17	10265707	10265707	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:10265707G>A	uc002gmk.1	-	4	408	c.318C>T	c.(316-318)CTC>CTT	p.L106L		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	106	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AGCGCTCTTTGAGGTTGTACA	0.443			NA											10	120					0	0	0.000978	0	0
MYH1	4619	broad.mit.edu	37	17	10419569	10419569	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:10419569C>A	uc002gmo.2	-	4	389	c.295G>T	c.(295-297)GAG>TAG	p.E99*	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	99	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACAGCAGGCTCGTGTAGATGA	0.473			NA											41	103					3.09479e-21	6.00621e-21	0.006999	1	0
C17orf63	55731	broad.mit.edu	37	17	27085330	27085330	+	Silent	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:27085330T>A	uc002hct.1	-	3	1914	c.1647A>T	c.(1645-1647)ACA>ACT	p.T549T	C17orf63_uc010wax.1_Silent_p.T549T|C17orf63_uc010way.1_Silent_p.T549T|C17orf63_uc002hcw.2_Silent_p.T421T	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	549										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			TTCGACTCTCTGTGGGATCGG	0.567			NA											11	31					0	0	0.001368	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29850980	29850980	+	Missense_Mutation	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:29850980A>C	uc002hgn.1	+	9	1328	c.1099A>C	c.(1099-1101)AAG>CAG	p.K367Q	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.K265Q	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	367	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				CCTGAAGAGCAAGCTGAAGCA	0.612			NA											6	21					0	0	0.001168	0	0
UNC45B	146862	broad.mit.edu	37	17	33501326	33501326	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:33501326G>T	uc002hja.2	+	14	1999	c.1902G>T	c.(1900-1902)CTG>CTT	p.L634L	UNC45B_uc002hjb.2_Silent_p.L632L|UNC45B_uc002hjc.2_Silent_p.L632L|UNC45B_uc010cto.2_Silent_p.L553L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	634					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				TCTCTGCCCTGGCTTGCATGG	0.567			NA											33	97					3.11337e-16	5.71211e-16	0.002836	1	0
AATF	26574	broad.mit.edu	37	17	35310239	35310239	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:35310239G>T	uc002hni.2	+	3	588	c.337G>T	c.(337-339)GGT>TGT	p.G113C	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	113	Glu-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				AGAGGGACTGGGTCTGGAGGA	0.483	NSCLC(49;901 1159 19183 41572 46244)		NA											16	66					0.000422831	0.000509294	0.004007	1	0
MRPL45	84311	broad.mit.edu	37	17	36478458	36478458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:36478458C>T	uc002hpy.2	+	8	1053	c.901C>T	c.(901-903)CAG>TAG	p.Q301*		NM_032351	NP_115727	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45 precursor	301					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGGAGAGGCCCAGAAGCCTCA	0.527			NA									OREG0024353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	29					0	0	0.000978	0	0
FBXL20	84961	broad.mit.edu	37	17	37453402	37453402	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:37453402C>A	uc010wed.1	-	6	597	c.376G>T	c.(376-378)GGG>TGG	p.G126W	FBXL20_uc002hrt.2_Missense_Mutation_p.G126W|FBXL20_uc010cvu.2_Missense_Mutation_p.G126W	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	126	LRR 2.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			TTTGTACACCCATTTAGATTC	0.368			NA											7	48					0.000274275	0.000331549	0.004482	1	0
KRT20	54474	broad.mit.edu	37	17	39036369	39036369	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:39036369C>G	uc002hvl.2	-	4	817	c.775G>C	c.(775-777)GAA>CAA	p.E259Q		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	259	Rod.|Coil 2.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				TCAAACTGTTCTTTGGCCTCT	0.418			NA											4	112					0	0	0.000248	0	0
KRT36	8689	broad.mit.edu	37	17	39645944	39645944	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:39645944C>G	uc002hwt.2	-	1	173	c.173G>C	c.(172-174)GGC>GCC	p.G58A		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	58	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				GCTCCCAAGGCCAGAGAGGCC	0.637			NA											17	70					0	0	0.00499	0	0
MPP3	4356	broad.mit.edu	37	17	41895456	41895456	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:41895456C>A	uc002iei.3	-	12	1070	c.904G>T	c.(904-906)GCG>TCG	p.A302S	MPP3_uc002ieh.2_Missense_Mutation_p.A327S|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Missense_Mutation_p.A302S|MPP3_uc010wik.1_Missense_Mutation_p.A327S	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	302					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		AGGGTGCCCGCGGCTCTCCGG	0.642			NA											3	8					0.00024832	0.000301804	0.000248	1	0
DCAKD	79877	broad.mit.edu	37	17	43111717	43111717	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:43111717C>A	uc002ihx.2	-	2	410	c.154G>T	c.(154-156)GTC>TTC	p.V52F	DCAKD_uc010daa.1_Missense_Mutation_p.V52F|DCAKD_uc010dab.1_Missense_Mutation_p.V52F|DCAKD_uc002ihy.2_Missense_Mutation_p.V52F	NM_024819	NP_079095	Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	52	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity				0		Prostate(33;0.155)				GTGCCGAAGACCTCTACGATG	0.617			NA											6	24					8.12818e-05	0.000101263	0.001984	1	0
NMT1	4836	broad.mit.edu	37	17	43183001	43183001	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:43183001A>G	uc002ihz.2	+	12	1503	c.1485A>G	c.(1483-1485)CTA>CTG	p.L495L	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	495					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				GACTGGTGCTACAATAACCAG	0.512			NA											16	58					0	0	0.00499	0	0
ABCC3	8714	broad.mit.edu	37	17	48734068	48734068	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:48734068G>T	uc002isl.2	+	3	308	c.228G>T	c.(226-228)CTG>CTT	p.L76L	ABCC3_uc002isk.3_Silent_p.L76L	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	76	Helical; Name=2; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CGCAGGTCCTGGGTGTCCTGC	0.597			NA											25	83					8.24728e-16	1.49073e-15	0.004656	1	0
MPO	4353	broad.mit.edu	37	17	56348200	56348200	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:56348200C>T	uc002ivu.1	-	12	2232	c.2055G>A	c.(2053-2055)GTG>GTA	p.V685V		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	685					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GCATGCTGAACACACCCTCGT	0.567			NA											6	57					0	0	0.001984	0	0
MARCH10	162333	broad.mit.edu	37	17	60821831	60821831	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:60821831T>C	uc010ddr.2	-	5	679	c.441A>G	c.(439-441)ACA>ACG	p.T147T	MARCH10_uc002jag.3_Silent_p.T147T|MARCH10_uc010dds.2_Silent_p.T185T|MARCH10_uc002jah.2_Silent_p.T146T	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	147							ligase activity|zinc ion binding				0						CTGGGCTGACTGTAAATCTCC	0.478			NA											24	77					0	0	0.00333	0	0
KCNH6	81033	broad.mit.edu	37	17	61607588	61607588	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:61607588G>C	uc002jay.2	+	3	524	c.444G>C	c.(442-444)CTG>CTC	p.L148L	KCNH6_uc002jax.1_Silent_p.L148L|KCNH6_uc010wpl.1_Silent_p.L25L|KCNH6_uc010wpm.1_Silent_p.L148L|KCNH6_uc002jaz.1_Silent_p.L148L	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	148	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCCAGCGCCTGTTGTCCCAGA	0.642			NA											6	28					0	0	0.001168	0	0
CSH2	1443	broad.mit.edu	37	17	61949662	61949663	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:61949662_61949663GG>CT	uc002jch.2	-	5	592_593	c.477_478CC>AG	c.(475-480)CGCCGG>CGAGGG	p.R160G	CSH2_uc002jcg.2_Missense_Mutation_p.R65G|CSH2_uc002jci.2_3'UTR|GH2_uc002jcj.2_Missense_Mutation_p.A158E|CSH2_uc002jck.2_Missense_Mutation_p.R160G	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	160					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						TGCCCAGTCCGGCGGCTGCCGT	0.55			NA											26	100					0	0	0.004672	0	0
CACNG5	27091	broad.mit.edu	37	17	64873633	64873633	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:64873633C>A	uc010wqi.1	+	2	420	c.183C>A	c.(181-183)GTC>GTA	p.V61V	CACNG5_uc002jfr.2_Silent_p.V61V|CACNG5_uc010wqj.1_Silent_p.V61V	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	61					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TCTGGCGGGTCTGCTTCCTTG	0.617			NA											11	23					3.86212e-05	4.87942e-05	0.008291	1	0
ABCA9	10350	broad.mit.edu	37	17	67047243	67047243	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:67047243C>A	uc002jhu.2	-	2	168	c.25G>T	c.(25-27)GGT>TGT	p.G9C	ABCA9_uc010dez.2_Missense_Mutation_p.G9C|ABCA9_uc002jhv.2_Missense_Mutation_p.G9C	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	9					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					GTTTGCTGACCCACGCTCATG	0.388			NA											8	50					0.000157383	0.000191976	0.00308	1	0
ABCA10	10349	broad.mit.edu	37	17	67190585	67190585	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:67190585T>G	uc010dfa.1	-	13	2165	c.1286A>C	c.(1285-1287)AAT>ACT	p.N429T	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.N30T	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	429	ATP 1 (Potential).|ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					ACCAGCTCCATTATGCCCAAG	0.333			NA											17	50					0	0	0.00499	0	0
CD300LB	124599	broad.mit.edu	37	17	72518919	72518919	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:72518919G>T	uc002jkx.2	-	4	688	c.675C>A	c.(673-675)TAC>TAA	p.Y225*		NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	188	Cytoplasmic (Potential).			Y->F: No effect on interaction with TYROBP, but strongly reduces activation properties.		integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGAAGTTCATGTAGATAGGCT	0.537			NA											15	70					6.72482e-11	1.09472e-10	0.003163	1	0
KCTD2	23510	broad.mit.edu	37	17	73055695	73055695	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:73055695G>C	uc002jmp.2	+	4	698	c.631G>C	c.(631-633)GAA>CAA	p.E211Q	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	211						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					CTGGAAATTCGAACAGGTACA	0.537			NA											4	43					0	0	0.000602	0	0
RECQL5	9400	broad.mit.edu	37	17	73662539	73662539	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:73662539T>C	uc010dgl.2	-	2	255	c.99A>G	c.(97-99)TTA>TTG	p.L33L	RECQL5_uc010dgk.2_Silent_p.L33L|RECQL5_uc002jpb.1_Silent_p.L33L|RECQL5_uc002joz.3_Silent_p.L33L|RECQL5_uc002jpa.3_Silent_p.L33L|SAP30BP_uc010dgm.1_5'Flank|SAP30BP_uc002jpc.1_5'Flank|SAP30BP_uc010wsf.1_5'Flank|SAP30BP_uc010wsg.1_5'Flank|SAP30BP_uc002jpe.2_5'Flank|SAP30BP_uc002jpf.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	33					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CACTCTCCTGTAAAGGCGTCT	0.483			NA						Other_identified_genes_with_known_or_suspected_DNA_repair_function					23	58					0	0	0.00333	0	0
EVPL	2125	broad.mit.edu	37	17	74005011	74005011	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:74005011G>A	uc002jqi.2	-	22	4503	c.4275C>T	c.(4273-4275)TTC>TTT	p.F1425F	EVPL_uc010wss.1_Silent_p.F1447F|EVPL_uc010wst.1_Silent_p.F895F	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1425	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GGTCCTCCTGGAAGCTGAGCA	0.692			NA											11	61					0	0	0.001855	0	0
DNAH17	8632	broad.mit.edu	37	17	76565498	76565498	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:76565498T>A	uc002jvv.1	-	4	368	c.262A>T	c.(262-264)ACG>TCG	p.T88S						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AAGTCGTACGTCTGGTAGAGC	0.562			NA											4	9					0	0	0.000602	0	0
CCDC137	339230	broad.mit.edu	37	17	79638803	79638803	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:79638803G>T	uc002kbc.3	+	4	563	c.527G>T	c.(526-528)CGA>CTA	p.R176L	CCDC137_uc002kbd.2_RNA	NM_199287	NP_954981	Q6PK04	CC137_HUMAN	coiled-coil domain containing 137	176	Potential.									central_nervous_system(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GATAAAGTCCGACGGAAAAAG	0.577			NA											6	73					0.00198382	0.00231877	0.001984	1	0
COLEC12	81035	broad.mit.edu	37	18	321716	321716	+	Missense_Mutation	SNP	C	C	A	rs141957359		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:321716C>A	uc002kkm.2	-	9	2370	c.2155G>T	c.(2155-2157)GAT>TAT	p.D719Y		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	719	Extracellular (Potential).|C-type lectin.	Calcium 3.|Carbohydrate; via carbonyl oxygen (By similarity).			carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CATTGGAAATCGTTCCACTGC	0.483			NA											28	163					5.45727e-16	9.89084e-16	0.008361	1	0
MC2R	4158	broad.mit.edu	37	18	13885436	13885436	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:13885436C>A	uc002ksp.1	-	2	259	c.82G>T	c.(82-84)GAG>TAG	p.E28*		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	28	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AATATCTCCTCCGGCAAAACC	0.413	Colon(141;1584 1782 35999 48227 48692)		NA											9	36					0.00621372	0.00712032	0.006214	1	0
CTAGE1	64693	broad.mit.edu	37	18	19996602	19996602	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:19996602G>A	uc002ktv.1	-	1	1277	c.1173C>T	c.(1171-1173)ATC>ATT	p.I391I		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	391	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TGGCATGGCTGATCATTTCGT	0.343			NA											16	169					0	0	0.004007	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996730	19996730	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:19996730G>T	uc002ktv.1	-	1	1149	c.1045C>A	c.(1045-1047)CAG>AAG	p.Q349K		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	349	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGTTTCTGCTGAAGCTTCTGA	0.328			NA											18	105					9.16793e-09	1.38968e-08	0.00499	1	0
ZNF521	25925	broad.mit.edu	37	18	22804767	22804767	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:22804767C>A	uc002kvk.2	-	4	3362	c.3115G>T	c.(3115-3117)GGG>TGG	p.G1039W	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G1039W|ZNF521_uc002kvl.2_Missense_Mutation_p.G819W	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1039	C2H2-type 24.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGGAACGTCCCATGGATTTTG	0.532			NA	T	PAX5	ALL								11	28					1.08611e-07	1.56675e-07	0.000978	1	0
ZNF521	25925	broad.mit.edu	37	18	22804769	22804769	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:22804769T>A	uc002kvk.2	-	4	3360	c.3113A>T	c.(3112-3114)CAT>CTT	p.H1038L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.H1038L|ZNF521_uc002kvl.2_Missense_Mutation_p.H818L	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1038	C2H2-type 24.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GAACGTCCCATGGATTTTGAG	0.537			NA	T	PAX5	ALL								11	28					0	0	0.000978	0	0
DTNA	1837	broad.mit.edu	37	18	32455254	32455254	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:32455254C>A	uc010dmn.1	+	17	1715	c.1714C>A	c.(1714-1716)CCA>ACA	p.P572T	DTNA_uc002kxw.2_Missense_Mutation_p.P515T|DTNA_uc010dmj.2_Missense_Mutation_p.P512T|DTNA_uc002kxz.2_Missense_Mutation_p.P519T|DTNA_uc002kxy.2_Missense_Mutation_p.P512T|DTNA_uc010xby.1_Missense_Mutation_p.P262T|DTNA_uc010xbz.1_Missense_Mutation_p.P281T|DTNA_uc010xca.1_Missense_Mutation_p.P224T|DTNA_uc002kye.2_Missense_Mutation_p.P220T	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	572					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						CATCAGCAGGCCAATTCCCAT	0.587			NA											9	34					0.00621372	0.00712032	0.006214	1	0
LIPG	9388	broad.mit.edu	37	18	47101900	47101900	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:47101900G>T	uc002ldv.2	+	5	985	c.733G>T	c.(733-735)GGG>TGG	p.G245W	LIPG_uc002ldu.1_Missense_Mutation_p.G245W|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	245					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CTACCCCAATGGGGGTGACTT	0.493	Pancreas(126;280 1778 12814 26243 34948)		NA											6	21					0.000157383	0.000191976	0.00308	1	0
MYO5B	4645	broad.mit.edu	37	18	47511162	47511162	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:47511162C>G	uc002leb.2	-	8	1160	c.872G>C	c.(871-873)GGA>GCA	p.G291A	MYO5B_uc002lec.1_Missense_Mutation_p.G290A	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	291	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGTGTCTCCTCCCTGTGATGT	0.522			NA											9	30					0	0	0.004482	0	0
MALT1	10892	broad.mit.edu	37	18	56414758	56414758	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:56414758G>T	uc002lhm.1	+	17	2417	c.2159G>T	c.(2158-2160)GGT>GTT	p.G720V	MALT1_uc002lhn.1_Missense_Mutation_p.G709V	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	720					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						ATGCATCGAGGTTTGGGAAGG	0.433			NA	T	BIRC3	MALT								21	85					2.21704e-12	3.74055e-12	0.00278	1	0
CBLN2	147381	broad.mit.edu	37	18	70209247	70209247	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:70209247C>A	uc002lku.2	-	2	384	c.149G>T	c.(148-150)CGG>CTG	p.R50L	CBLN2_uc002lkv.2_Missense_Mutation_p.R50L	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	50						integral to membrane					0		Esophageal squamous(42;0.131)				GTTCTGCGCCCGCACGGGGCA	0.602			NA											4	12					3.59834e-05	4.57629e-05	0.001168	1	0
CDC34	997	broad.mit.edu	37	19	537086	537086	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:537086G>T	uc002lov.2	+	4	635	c.436G>T	c.(436-438)GTG>TTG	p.V146L		NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	146					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACGCCTCCGTGATGTACAG	0.617			NA											12	53					3.07112e-06	4.16617e-06	0.000978	1	0
POLRMT	5442	broad.mit.edu	37	19	624806	624806	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:624806C>G	uc002lpf.1	-	5	1109	c.1053G>C	c.(1051-1053)GTG>GTC	p.V351V		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	351					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCACCTTGTGCACGGCCTTCA	0.637			NA											19	42					0	0	0.001882	0	0
TCF3	6929	broad.mit.edu	37	19	1623968	1623968	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:1623968C>A	uc002ltr.2	-	8	598	c.531G>T	c.(529-531)CCG>CCT	p.P177P	TCF3_uc002lto.2_5'Flank|TCF3_uc002ltt.3_Silent_p.P177P|TCF3_uc002ltq.2_Silent_p.P126P|TCF3_uc002lts.1_Silent_p.P93P	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	177					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGACCCGGCGGGACCTTCC	0.632			NA	T	PBX1|HLF|TFPT	pre B-ALL								7	13					0.00448238	0.00518058	0.004482	1	0
TIMM44	10469	broad.mit.edu	37	19	7997545	7997545	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:7997545C>A	uc002miz.2	-	9	956	c.954G>T	c.(952-954)CAG>CAT	p.Q318H	TIMM44_uc002mja.2_Missense_Mutation_p.Q58H|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	318					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CGTTCTCGCACTGTTTCAGAA	0.647			NA											17	30					1.56452e-12	2.64963e-12	0.007413	1	0
FBN3	84467	broad.mit.edu	37	19	8175977	8175977	+	Missense_Mutation	SNP	C	C	A	rs145427911	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:8175977C>A	uc002mjf.2	-	32	4196	c.4175G>T	c.(4174-4176)GGC>GTC	p.G1392V		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1392	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGGGTCAAAGCCCATCTCACA	0.657			NA											7	19					2.0095e-06	2.76512e-06	0.001984	1	0
ZNF823	55552	broad.mit.edu	37	19	11832562	11832562	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:11832562C>A	uc002msm.2	-	4	1913	c.1787G>T	c.(1786-1788)CGT>CTT	p.R596L	ZNF823_uc010xmd.1_Missense_Mutation_p.R414L|ZNF823_uc010dyi.1_Missense_Mutation_p.R552L	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	596	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATGCAAGGAACGGAGAGAACT	0.398			NA								HNSCC(68;0.2)			19	51					1.15919e-05	1.52926e-05	0.001216	1	0
PLVAP	83483	broad.mit.edu	37	19	17476209	17476209	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:17476209C>A	uc002ngk.1	-	3	1115	c.1065G>T	c.(1063-1065)CGG>CGT	p.R355R		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	355	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTCGTTCCTTCCGCAGCACCG	0.617			NA											15	40					6.72482e-11	1.09472e-10	0.003163	1	0
ZNF682	91120	broad.mit.edu	37	19	20117282	20117282	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:20117282A>G	uc002noq.2	-	4	1152	c.1029T>C	c.(1027-1029)TGT>TGC	p.C343C	ZNF682_uc002noo.2_Silent_p.C311C|ZNF682_uc002nop.2_Silent_p.C311C|ZNF682_uc010eck.2_Silent_p.C267C	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	343	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						CACATTCTTCACATTTATAGG	0.373			NA											19	37					0	0	0.007413	0	0
CCNE1	898	broad.mit.edu	37	19	30314607	30314607	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:30314607G>T	uc002nsn.2	+	12	1339	c.1156G>T	c.(1156-1158)GCT>TCT	p.A386S	CCNE1_uc002nso.2_Missense_Mutation_p.A371S|CCNE1_uc002nsp.2_Missense_Mutation_p.A133S	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	386					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			ACAAAATAGGGCTTCTCCTCT	0.522			NA											8	53					1.06961e-07	1.55129e-07	0.00308	1	0
ZNF536	9745	broad.mit.edu	37	19	30936469	30936469	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:30936469G>T	uc002nsu.1	+	2	2138	c.2000G>T	c.(1999-2001)GGC>GTC	p.G667V	ZNF536_uc010edd.1_Missense_Mutation_p.G667V	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	667					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGCACGTGGGCCTGGATGAG	0.697			NA											14	29					1.36491e-13	2.38371e-13	0.001855	1	0
ZNF536	9745	broad.mit.edu	37	19	31039909	31039909	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:31039909G>T	uc002nsu.1	+	4	3521	c.3383G>T	c.(3382-3384)AGT>ATT	p.S1128I	ZNF536_uc010edd.1_Missense_Mutation_p.S1128I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGGCCTCCAGTTCCTGCCCC	0.547			NA											14	38					3.27435e-08	4.84835e-08	0.00245	1	0
KIRREL2	84063	broad.mit.edu	37	19	36353928	36353928	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:36353928G>T	uc002ocb.3	+	13	1927	c.1715G>T	c.(1714-1716)CGC>CTC	p.R572L	KIRREL2_uc002obz.3_Missense_Mutation_p.R572L|KIRREL2_uc002oca.3_Missense_Mutation_p.R522L|KIRREL2_uc002occ.3_Missense_Mutation_p.R519L|KIRREL2_uc002ocd.3_Missense_Mutation_p.R534L	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	572	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACAGGCAGCCGCGAGGACCGG	0.577			NA											3	12					6.4e-05	8.03467e-05	0.004672	1	0
ZNF566	84924	broad.mit.edu	37	19	36940320	36940320	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:36940320T>C	uc002oea.3	-	5	898	c.816A>G	c.(814-816)CGA>CGG	p.R272R	ZNF566_uc010xte.1_Silent_p.R272R|ZNF566_uc010xtf.1_Silent_p.R273R|ZNF566_uc002oeb.3_Silent_p.R272R|ZNF566_uc002oec.3_Silent_p.R168R|ZNF566_uc010xtg.1_Silent_p.R168R	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	272	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TTCTCTGATGTCGAGTGAAGT	0.423			NA											10	65					0	0	0.008291	0	0
HKR1	284459	broad.mit.edu	37	19	37854289	37854289	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:37854289G>T	uc002ogb.2	+	6	1861	c.1592G>T	c.(1591-1593)GGA>GTA	p.G531V	HKR1_uc002ofx.2_Missense_Mutation_p.G247V|HKR1_uc002ofy.2_Missense_Mutation_p.G247V|HKR1_uc002oga.2_Missense_Mutation_p.G513V|HKR1_uc010xto.1_Missense_Mutation_p.G513V|HKR1_uc002ogc.2_Missense_Mutation_p.G512V|HKR1_uc010xtp.1_Missense_Mutation_p.G470V|HKR1_uc002ogd.2_Missense_Mutation_p.G470V	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	531	C2H2-type 9.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCTGAGTGTGGACGAGGCTTT	0.522			NA											20	47					1.9806e-07	2.84182e-07	0.002299	1	0
FAM98C	147965	broad.mit.edu	37	19	38899419	38899419	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:38899419G>T	uc002oin.1	+	8	966	c.947G>T	c.(946-948)GGG>GTG	p.G316V	FAM98C_uc002oio.1_Missense_Mutation_p.G234V|FAM98C_uc010xtz.1_Silent_p.G182G	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	316										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCAGACCGGGGGGGCCGCCCA	0.557			NA											10	82					2.17888e-05	2.81911e-05	0.006214	1	0
PAPL	390928	broad.mit.edu	37	19	39591247	39591247	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:39591247C>A	uc002oki.2	+	6	931	c.657C>A	c.(655-657)TTC>TTA	p.F219L	PAPL_uc010egl.2_Nonsense_Mutation_p.S178*	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	219						extracellular region	acid phosphatase activity|metal ion binding				0						AGGCTCGCTTCAGCATGCCGG	0.557			NA											29	98					6.19805e-25	1.21696e-24	0.005524	1	0
RPS16	6217	broad.mit.edu	37	19	39924008	39924010	+	Missense_Mutation	TNP	CAT	CAT	ATA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CAT	CAT	-	-	CAT	CAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:39924008_39924010CAT>ATA	uc002olk.2	-	5	427_429	c.344_346ATG>TAT	c.(343-348)TATGAC>TTATAC	p.115_116YD>LY	RPS16_uc002oll.2_Missense_Mutation_p.98_99YD>LY|RPS16_uc002olm.2_Missense_Mutation_p.M147Y	NM_001020	NP_001011	P62249	RS16_HUMAN	ribosomal protein S16	115_116					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			skin(1)	1	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGGTCCGGTCATACTGGATGAG	0.537			NA											10	55					0	0	0.004672	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41445035	41445035	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:41445035G>T	uc010ehg.1	+	4	654	c.646G>T	c.(646-648)GTC>TTC	p.V216F	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Splice_Site_p.Q215_splice|CYP2B7P1_uc002opq.2_Splice_Site					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						ATCCAGCCAGGTCCAGGAGAG	0.507			NA											5	23					3.59834e-05	4.57629e-05	0.001168	1	0
CEACAM4	1089	broad.mit.edu	37	19	42131976	42131976	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:42131976G>T	uc002orh.1	-	2	534	c.423C>A	c.(421-423)CAC>CAA	p.H141Q	CEACAM4_uc010xwd.1_Missense_Mutation_p.H141Q	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	141	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						ATCACTCACGGTGTACGTGGA	0.552			NA											24	108					7.92952e-12	1.32951e-11	0.003954	1	0
ZNF574	64763	broad.mit.edu	37	19	42584394	42584394	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:42584394A>T	uc002osm.3	+	2	1805	c.1636A>T	c.(1636-1638)ACA>TCA	p.T546S	ZNF574_uc002osk.3_Missense_Mutation_p.T636S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCTCACACACACAGGAGAGCG	0.652			NA											29	102					0	0	0.00632	0	0
MEGF8	1954	broad.mit.edu	37	19	42855448	42855448	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:42855448C>T	uc002otl.3	+	15	3251	c.2616C>T	c.(2614-2616)GCC>GCT	p.A872A	MEGF8_uc002otm.3_Silent_p.A480A	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	939	Extracellular (Potential).|PSI 3.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GTCGGGGTGCCCTGAAGAGTC	0.677			NA											4	7					0	0	0.000602	0	0
ZNF223	7766	broad.mit.edu	37	19	44570336	44570336	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:44570336A>G	uc002oyf.1	+	5	608	c.355A>G	c.(355-357)ATA>GTA	p.I119V	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AGACTCTACCATAAAGAGCTC	0.473			NA											21	48					0	0	0.001523	0	0
ZNF226	7769	broad.mit.edu	37	19	44679961	44679961	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:44679961G>C	uc002oyp.2	+	6	690	c.546G>C	c.(544-546)CAG>CAC	p.Q182H	ZNF226_uc002oyq.2_Missense_Mutation_p.Q65H|ZNF226_uc002oyr.2_Missense_Mutation_p.Q65H|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.Q182H|ZNF226_uc002oyt.2_Missense_Mutation_p.Q182H	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CTGAGTCACAGAGATTGAACA	0.378	Pancreas(115;581 1665 13228 19278 50070)		NA											8	28					0	0	0.004482	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48511980	48511980	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:48511980A>G	uc002pht.2	+	2	211	c.56A>G	c.(55-57)TAT>TGT	p.Y19C		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	19					single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		CTCTATTCCTATGAGTCAAGT	0.438			NA											8	23					0	0	0.006214	0	0
MED25	81857	broad.mit.edu	37	19	50332242	50332242	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:50332242G>T	uc002ppw.1	+	5	473	c.420G>T	c.(418-420)CGG>CGT	p.R140R	MED25_uc010ybe.1_Intron|MED25_uc002ppx.1_5'Flank	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	140	Interaction with the Mediator complex.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		AGACGCACCGGGTCTGCCTCC	0.562	GBM(51;894 1657 37868)		NA											6	25					2.0095e-06	2.76512e-06	0.001984	1	0
CLEC11A	6320	broad.mit.edu	37	19	51228646	51228646	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:51228646G>T	uc002psy.2	+	4	1072	c.894G>T	c.(892-894)GCG>GCT	p.A298A		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	298	C-type lectin.				positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		ACTGCGTGGCGCAGGCCTCTG	0.721			NA											8	15					0.000673444	0.000798266	0.008291	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51920552	51920552	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:51920552T>C	uc002pwo.2	-	2	821	c.205A>G	c.(205-207)AAG>GAG	p.K69E	SIGLEC10_uc002pwp.2_Missense_Mutation_p.K69E|SIGLEC10_uc002pwq.2_Missense_Mutation_p.K69E|SIGLEC10_uc002pwr.2_Missense_Mutation_p.K69E|SIGLEC10_uc010ycy.1_Missense_Mutation_p.K69E|SIGLEC10_uc010ycz.1_Missense_Mutation_p.K69E|SIGLEC10_uc010eow.2_Intron|SIGLEC10_uc002pws.1_Missense_Mutation_p.K53E	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	69	Extracellular (Potential).|Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGAGCACCCTTGGTTGTCTCA	0.592			NA											19	43					0	0	0.007413	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983926	51983926	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:51983926A>T	uc002pwv.1	+	3	575	c.575A>T	c.(574-576)GAG>GTG	p.E192V		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	192						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGCTGGCTGGAGGTTCTAGGT	0.438			NA											8	36					0	0	0.006214	0	0
ZNF480	147657	broad.mit.edu	37	19	52825580	52825580	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:52825580A>G	uc010ydl.1	+	5	1147	c.1077A>G	c.(1075-1077)GTA>GTG	p.V359V	ZNF480_uc002pyv.2_Silent_p.V282V|ZNF480_uc010ydm.1_Silent_p.V316V|ZNF480_uc010epn.2_Silent_p.V190V|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	359	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		CGCTCCTTGTACGACATCAGA	0.378			NA											8	66					0	0	0.00308	0	0
ZNF665	79788	broad.mit.edu	37	19	53668312	53668312	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:53668312C>A	uc010eqm.1	-	4	1531	c.1431G>T	c.(1429-1431)CGG>CGT	p.R477R		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	412	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		AATGAATTCCCCGATGACTTG	0.428			NA											15	88					4.93089e-13	8.53375e-13	0.00245	1	0
CACNG7	59284	broad.mit.edu	37	19	54444782	54444782	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:54444782G>T	uc002qcr.1	+	4	498	c.483G>T	c.(481-483)ATG>ATT	p.M161I	CACNG7_uc010era.1_Missense_Mutation_p.M161I	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	161					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		ACGAGGTCATGAACAGGCCCA	0.562			NA											12	97					2.68362e-12	4.52208e-12	0.001368	1	0
LILRB2	10288	broad.mit.edu	37	19	54783326	54783326	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:54783326G>T	uc002qfb.2	-	5	798	c.532C>A	c.(532-534)CGC>AGC	p.R178S	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.R178S|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.R178S|LILRB2_uc010yet.1_Missense_Mutation_p.R62S|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	178	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AAGATGGCGCGGGACGACCCA	0.577			NA											24	90					7.87624e-14	1.38634e-13	0.00278	1	0
LILRA3	11026	broad.mit.edu	37	19	54803141	54803141	+	Missense_Mutation	SNP	C	C	T	rs147561158	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:54803141C>T	uc002qfd.2	-	4	601	c.536G>A	c.(535-537)CGG>CAG	p.R179Q	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	179	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GAAGATGGCCCGGGATGACCC	0.567			NA											16	101					0	0	0.004007	0	0
LILRA2	11027	broad.mit.edu	37	19	55085572	55085572	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:55085572C>A	uc002qgg.3	+	2	153	c.64C>A	c.(64-66)CAG>AAG	p.Q22K	LILRA2_uc010ern.2_Missense_Mutation_p.Q22K|LILRA2_uc002qgf.2_Missense_Mutation_p.Q22K|LILRA2_uc010yfe.1_Missense_Mutation_p.Q22K|LILRA2_uc010yff.1_Intron|LILRA2_uc010ero.2_Intron|LILRA2_uc010yfg.1_Missense_Mutation_p.Q22K	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	22					defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GACCCACGTGCAGGCAGGTGA	0.632			NA											19	68					1.50039e-11	2.49693e-11	0.001882	1	0
KIR2DL4	3805	broad.mit.edu	37	19	55316358	55316358	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:55316358T>C	uc010yfm.1	+	3	227	c.187T>C	c.(187-189)TAC>CAC	p.Y63H	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Missense_Mutation_p.Y58H|KIR2DL4_uc002qhg.2_Missense_Mutation_p.Y63H|KIR2DL4_uc002qhi.2_Missense_Mutation_p.Y63H|KIR2DL4_uc002qhh.2_Intron|KIR2DL4_uc002qhj.2_Missense_Mutation_p.Y63H|KIR2DL4_uc002qhf.2_Intron|KIR2DL4_uc010esd.2_Missense_Mutation_p.Y63H|KIR2DL4_uc010ese.2_5'Flank	NM_002255	NP_002246	Q99706	KI2L4_HUMAN	killer cell immunoglobulin-like receptor, two	63	Ig-like C2-type 1.|Extracellular (Potential).				cellular defense response|regulation of immune response	integral to plasma membrane	protein binding|transmembrane receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0192)		CTTCACGCTGTACAAGAAAGA	0.547			NA											15	41					0	0	0.006122	0	0
NCR1	9437	broad.mit.edu	37	19	55421391	55421391	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:55421391C>G	uc002qib.2	+	5	686	c.648C>G	c.(646-648)AAC>AAG	p.N216K	NCR1_uc002qic.2_Missense_Mutation_p.N216K|NCR1_uc002qie.2_Missense_Mutation_p.N216K|NCR1_uc002qid.2_Missense_Mutation_p.N121K|NCR1_uc002qif.2_Missense_Mutation_p.N121K|NCR1_uc010esj.2_Missense_Mutation_p.N109K	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	216	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		ACATTGAGAACACCAGCCTTG	0.418			NA											32	112					0	0	0.002096	0	0
NLRP13	126204	broad.mit.edu	37	19	56416458	56416458	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:56416458G>T	uc010ygg.1	-	8	2493	c.2468C>A	c.(2467-2469)TCG>TAG	p.S823*		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	823							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCTGGCTGCCGACAAGTTGCA	0.527			NA											7	39					0.000157383	0.000191976	0.00308	1	0
NLRP8	126205	broad.mit.edu	37	19	56490764	56490764	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:56490764G>T	uc002qmh.2	+	9	2952	c.2881G>T	c.(2881-2883)GAA>TAA	p.E961*	NLRP8_uc010etg.2_Nonsense_Mutation_p.E942*	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	961						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCACAGGCTGGAAAACTGCCT	0.512			NA											11	84					3.86212e-05	4.87942e-05	0.008291	1	0
DUXA	503835	broad.mit.edu	37	19	57666724	57666724	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:57666724C>T	uc002qoa.1	-	5	500	c.455G>A	c.(454-456)CGA>CAA	p.R152Q		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	152	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TCTAGATCTTCGATTTTGGAA	0.378			NA											13	39					0	0	0.003163	0	0
DUXA	503835	broad.mit.edu	37	19	57666732	57666732	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:57666732G>T	uc002qoa.1	-	5	492	c.447C>A	c.(445-447)TTC>TTA	p.F149L		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	149	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TTCGATTTTGGAACCAAATCT	0.368			NA											12	32					1.5842e-08	2.38251e-08	0.001855	1	0
ZNF417	147687	broad.mit.edu	37	19	58420783	58420783	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:58420783C>A	uc002qqq.2	-	3	1062	c.863G>T	c.(862-864)CGA>CTA	p.R288L	ZNF417_uc010yhm.1_Missense_Mutation_p.R245L|ZNF417_uc002qqr.2_Missense_Mutation_p.R287L	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	288	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		AGTGTGGACTCGCTGATGTTG	0.458			NA											31	107					5.45727e-16	9.89084e-16	0.008361	1	0
ZNF606	80095	broad.mit.edu	37	19	58491351	58491351	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:58491351G>A	uc002qqw.2	-	7	1315	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	ZNF606_uc010yhp.1_Nonsense_Mutation_p.Q143*	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGTTCTATCTGAGAAACTCTC	0.393			NA											9	95					0	0	0.004482	0	0
TPO	7173	broad.mit.edu	37	2	1418272	1418272	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:1418272G>T	uc002qww.2	+	2	183	c.92G>T	c.(91-93)TGG>TTG	p.W31L	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Missense_Mutation_p.W31L|TPO_uc002qwu.2_Missense_Mutation_p.W31L|TPO_uc002qwr.2_Missense_Mutation_p.W31L|TPO_uc002qwx.2_Missense_Mutation_p.W31L|TPO_uc010yio.1_Missense_Mutation_p.W31L|TPO_uc010yip.1_Missense_Mutation_p.W31L	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	31	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GAACTCCTTTGGGGTAAGTAG	0.448			NA											14	24					1.3612e-06	1.8944e-06	0.003163	1	0
MYT1L	23040	broad.mit.edu	37	2	1926164	1926164	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:1926164C>A	uc002qxe.2	-	10	2204	c.1377G>T	c.(1375-1377)AGG>AGT	p.R459S	MYT1L_uc002qxd.2_Missense_Mutation_p.R459S|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	459					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCATATTGTCCCTCCTCCCAG	0.522			NA											24	111					7.87624e-14	1.38634e-13	0.00278	1	0
COLEC11	78989	broad.mit.edu	37	2	3691331	3691332	+	Missense_Mutation	DNP	CG	CG	AC			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:3691331_3691332CG>AC	uc002qya.2	+	7	587_588	c.439_440CG>AC	c.(439-441)CGC>ACC	p.R147T	COLEC11_uc002qxz.2_Missense_Mutation_p.R144T|COLEC11_uc002qyb.2_Missense_Mutation_p.R123T|COLEC11_uc002qyc.2_Missense_Mutation_p.R123T|COLEC11_uc010ewo.2_Missense_Mutation_p.R99T|COLEC11_uc010ewp.2_Missense_Mutation_p.R121T|COLEC11_uc010ewq.2_Missense_Mutation_p.R97T|COLEC11_uc010ewr.2_Missense_Mutation_p.R97T|COLEC11_uc010ews.2_Missense_Mutation_p.R73T	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	147	Potential.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CGCCGGTGTGCGCGAGACGGAG	0.634			NA											12	43					0	0	0.004672	0	0
ASAP2	8853	broad.mit.edu	37	2	9531320	9531320	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:9531320C>A	uc002qzh.2	+	23	2853	c.2513C>A	c.(2512-2514)TCT>TAT	p.S838Y	ASAP2_uc002qzi.2_Intron	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	838	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						CGCGTGACATCTACCAGTACG	0.567			NA											27	84					9.39395e-14	1.64701e-13	0.00632	1	0
APOB	338	broad.mit.edu	37	2	21251391	21251391	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:21251391T>A	uc002red.2	-	13	1765	c.1637A>T	c.(1636-1638)CAG>CTG	p.Q546L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	546	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAGGAAAGTCTGAAGAAGAAC	0.468			NA											16	58					0	0	0.00499	0	0
C2orf84	653140	broad.mit.edu	37	2	24413446	24413446	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:24413446C>A	uc002rfc.2	+	6	653	c.567C>A	c.(565-567)GGC>GGA	p.G189G	C2orf84_uc010eyc.2_RNA	NM_001040710	NP_001035800	Q86W67	CB084_HUMAN	hypothetical protein LOC653140	189											0						TGGGGCGGGGCTGGCATGCAG	0.597			NA											17	44					5.35267e-07	7.53525e-07	0.007413	1	0
ITSN2	50618	broad.mit.edu	37	2	24533223	24533223	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:24533223G>C	uc002rfe.2	-	7	841	c.583C>G	c.(583-585)CTG>GTG	p.L195V	ITSN2_uc002rff.2_Missense_Mutation_p.L195V|ITSN2_uc002rfg.2_Missense_Mutation_p.L195V|ITSN2_uc010eyd.2_Missense_Mutation_p.L195V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	195					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCATCATCAGACTATAAGAT	0.343			NA											77	199					0	0	0.00361	0	0
NCOA1	8648	broad.mit.edu	37	2	24949555	24949555	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:24949555A>G	uc002rfk.2	+	13	2955	c.2697A>G	c.(2695-2697)ATA>ATG	p.I899M	NCOA1_uc010eye.2_Missense_Mutation_p.I899M|NCOA1_uc002rfi.2_Missense_Mutation_p.I748M|NCOA1_uc002rfj.2_Missense_Mutation_p.I899M|NCOA1_uc002rfl.2_Missense_Mutation_p.I899M	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	899	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACAGCTATAAATCAGAGTA	0.343			NA	T	PAX3	alveolar rhadomyosarcoma								7	37					0	0	0.001984	0	0
C2orf18	54978	broad.mit.edu	37	2	27001193	27001193	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:27001193G>T	uc002rhp.1	+	6	1006	c.930G>T	c.(928-930)CTG>CTT	p.L310L	C2orf18_uc002rhq.1_Silent_p.L227L|C2orf18_uc010eyo.1_Silent_p.L257L|C2orf18_uc010ylc.1_Silent_p.L163L	NM_017877	NP_060347	Q8N357	CB018_HUMAN	ANT2-binding protein precursor	310	Helical; (Potential).					integral to membrane|lysosomal membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTGGCACTGGGCTGGGAGG	0.612			NA											12	92					9.31168e-06	1.24063e-05	0.001855	1	0
GALNT14	79623	broad.mit.edu	37	2	31147103	31147103	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:31147103T>A	uc002rnr.2	-	13	1881	c.1262A>T	c.(1261-1263)AAG>ATG	p.K421M	GALNT14_uc002rnq.2_Missense_Mutation_p.K401M|GALNT14_uc002rns.2_Missense_Mutation_p.K426M|GALNT14_uc010ymr.1_Missense_Mutation_p.K386M|GALNT14_uc010ezo.1_Missense_Mutation_p.K388M	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	421	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GATATTGCCCTTCTGGATGGA	0.532			NA											17	97					0	0	0.006122	0	0
LTBP1	4052	broad.mit.edu	37	2	33412009	33412009	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:33412009T>A	uc002ros.2	+	6	1288	c.1288T>A	c.(1288-1290)TGT>AGT	p.C430S	LTBP1_uc002rot.2_Missense_Mutation_p.C104S|LTBP1_uc002rou.2_Missense_Mutation_p.C104S|LTBP1_uc002rov.2_Missense_Mutation_p.C104S|LTBP1_uc010ymz.1_Missense_Mutation_p.C104S|LTBP1_uc010yna.1_Missense_Mutation_p.C104S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	430	EGF-like 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGGAAAACTTTGTCAGATCCC	0.478			NA											19	31					0	0	0.006122	0	0
LTBP1	4052	broad.mit.edu	37	2	33488390	33488390	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:33488390C>A	uc002ros.2	+	15	2551	c.2551C>A	c.(2551-2553)CCT>ACT	p.P851T	LTBP1_uc002rot.2_Missense_Mutation_p.P525T|LTBP1_uc002rou.2_Missense_Mutation_p.P524T|LTBP1_uc002rov.2_Missense_Mutation_p.P471T|LTBP1_uc010ymz.1_Missense_Mutation_p.P524T|LTBP1_uc010yna.1_Missense_Mutation_p.P471T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	850					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ACCTCCTGTGCCTGTTGAAGT	0.398			NA											16	58					1.3612e-06	1.8944e-06	0.003163	1	0
MAP4K3	8491	broad.mit.edu	37	2	39487871	39487871	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:39487871C>A	uc002rro.2	-	29	2275	c.2184G>T	c.(2182-2184)CTG>CTT	p.L728L	MAP4K3_uc002rrp.2_Silent_p.L707L|MAP4K3_uc010yns.1_Silent_p.L281L	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	728	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CAGGAACTACCAGCATTTCAA	0.363			NA											15	27					2.32078e-09	3.60742e-09	0.003163	1	0
SLC8A1	6546	broad.mit.edu	37	2	40405545	40405545	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:40405545C>G	uc002rrx.2	-	2	1921	c.1897G>C	c.(1897-1899)GAG>CAG	p.E633Q	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.E633Q|SLC8A1_uc002rrz.2_Intron|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Intron	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	633	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCACTCATCTCCACCAGGCGG	0.512			NA											34	215					0	0	0.004289	0	0
EML4	27436	broad.mit.edu	37	2	42488304	42488304	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:42488304A>G	uc002rsi.2	+	4	644	c.382A>G	c.(382-384)AAA>GAA	p.K128E	EML4_uc002rsh.3_Missense_Mutation_p.K128E|EML4_uc010fap.2_Intron	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	128					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						acagagagaaaaaaaagagga	0.274			NA	T	ALK	NSCLC								14	13					0	0	0.001855	0	0
SOCS5	9655	broad.mit.edu	37	2	46986566	46986566	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:46986566G>C	uc002rvf.2	+	2	1061	c.897G>C	c.(895-897)CTG>CTC	p.L299L	SOCS5_uc010yoe.1_Silent_p.L268L|SOCS5_uc002rvg.2_Silent_p.L299L	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	299					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TATATAAACTGGGACCAAAAT	0.433			NA											20	62					0	0	0.001523	0	0
NRXN1	9378	broad.mit.edu	37	2	50463932	50463932	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:50463932G>T	uc010fbp.2	-	2	1243	c.436C>A	c.(436-438)CAT>AAT	p.H146N	NRXN1_uc002rxb.3_Missense_Mutation_p.H853N|NRXN1_uc010fbq.2_Missense_Mutation_p.H1221N|NRXN1_uc002rxe.3_Missense_Mutation_p.H1181N|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	146	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding	p.H146L(1)		ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTTACTATATGCAGTTCTAGG	0.398			NA											10	18					7.48243e-07	1.04676e-06	0.006214	1	0
NRXN1	9378	broad.mit.edu	37	2	50780095	50780095	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:50780095C>A	uc010fbq.2	-	9	2986	c.1509G>T	c.(1507-1509)ATG>ATT	p.M503I	NRXN1_uc002rxb.3_Missense_Mutation_p.M135I|NRXN1_uc002rxe.3_Missense_Mutation_p.M463I|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATGGATCTTCATCTTAGGAT	0.418			NA											22	128					4.7796e-09	7.3444e-09	0.004656	1	0
GPR75	10936	broad.mit.edu	37	2	54080865	54080865	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:54080865C>A	uc002rxo.3	-	2	1300	c.1029G>T	c.(1027-1029)CAG>CAT	p.Q343H	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	343	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGAGAACCACCTGTACCAAGG	0.433			NA											20	36					6.33239e-15	1.13392e-14	0.001523	1	0
MTIF2	4528	broad.mit.edu	37	2	55471275	55471275	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:55471275C>G	uc002ryn.2	-	12	1938	c.1201G>C	c.(1201-1203)GAT>CAT	p.D401H	MTIF2_uc010yox.1_Missense_Mutation_p.D70H|MTIF2_uc002ryo.2_Missense_Mutation_p.D401H	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	401					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						CCATTTTCATCAAACATTAAG	0.398			NA											4	47					0	0	0.000602	0	0
MDH1	4190	broad.mit.edu	37	2	63832413	63832413	+	Splice_Site	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:63832413G>C	uc002scj.1	+	7	732	c.676_splice	c.e7-1	p.T226_splice	MDH1_uc010ypv.1_Splice_Site_p.T244_splice|MDH1_uc010ypw.1_Splice_Site_p.T131_splice	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase						gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)	CCCCTTCCCAGACTGTGCAGC	0.512			NA											5	21					0	0	0.000602	0	0
ALMS1	7840	broad.mit.edu	37	2	73650100	73650100	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:73650100G>C	uc002sje.1	+	5	876	c.765G>C	c.(763-765)CTG>CTC	p.L255L	ALMS1_uc002sjf.1_Silent_p.L212L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	254					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTGCACCTCTGAGGTAGGATG	0.398			NA											5	154					0	0	0.000602	0	0
TET3	200424	broad.mit.edu	37	2	74273589	74273589	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:74273589G>C	uc002skb.3	+	1	140	c.140G>C	c.(139-141)TGG>TCG	p.W47S	TET3_uc010fez.1_Missense_Mutation_p.W47S	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	47							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AAGCCCGACTGGGAGGCTGCC	0.647			NA											5	32					0	0	0.001168	0	0
DCTN1	1639	broad.mit.edu	37	2	74593378	74593378	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:74593378G>A	uc002skx.2	-	23	3064	c.2753C>T	c.(2752-2754)CCC>CTC	p.P918L	SLC4A5_uc002skl.2_5'Flank|DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Missense_Mutation_p.P784L|DCTN1_uc002sku.2_Missense_Mutation_p.P784L|DCTN1_uc002skw.1_Missense_Mutation_p.P894L|DCTN1_uc010ffd.2_Missense_Mutation_p.P898L|DCTN1_uc002sky.2_Missense_Mutation_p.P881L	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	918					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						TACCTTGCTGGGGGGCCGCTC	0.562			NA											31	72					0	0	0.003755	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975980	76975980	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:76975980G>T	uc002snr.2	-	4	2029	c.1614C>A	c.(1612-1614)TGC>TGA	p.C538*	LRRTM4_uc002snq.2_Nonsense_Mutation_p.C538*	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	538	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GGTGGGCCTGGCAGTACCCGA	0.537			NA											13	31					0.000219431	0.000267177	0.00245	1	0
REG1B	5968	broad.mit.edu	37	2	79313623	79313623	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:79313623C>A	uc002sny.2	-	4	303	c.191G>T	c.(190-192)TGC>TTC	p.C64F	REG1B_uc010ffv.1_Missense_Mutation_p.C64F|REG1B_uc010ffw.2_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	64	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						CATGTTCTGGCAATAGAGCTG	0.498			NA											18	80					8.28177e-16	1.49495e-15	0.007413	1	0
CTNNA2	1496	broad.mit.edu	37	2	79878723	79878723	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:79878723C>A	uc010ysh.1	+	1	46	c.41C>A	c.(40-42)CCC>CAC	p.P14H	CTNNA2_uc010yse.1_Missense_Mutation_p.P14H|CTNNA2_uc010ysf.1_Missense_Mutation_p.P14H|CTNNA2_uc010ysg.1_Missense_Mutation_p.P14H|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	14					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AAATGGGACCCCAAAAGTTTG	0.398			NA											15	68					1.33834e-09	2.09242e-09	0.007413	1	0
SFTPB	6439	broad.mit.edu	37	2	85893739	85893739	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:85893739C>A	uc002sqh.2	-	4	399	c.393_splice	c.e4+1	p.T131_splice	SFTPB_uc002sqi.2_Splice_Site_p.T143_splice|SFTPB_uc002sqj.2_Splice_Site_p.T131_splice	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B						organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						GCAGCCCTCACAGTCTGGTTC	0.607			NA											18	35					9.7654e-05	0.000121435	0.007413	1	0
CD8A	925	broad.mit.edu	37	2	87017548	87017548	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:87017548C>G	uc002srt.2	-	2	1195	c.306G>C	c.(304-306)CTG>CTC	p.L102L	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Silent_p.L102L|CD8A_uc010ytn.1_Silent_p.L143L|CD8A_uc002sru.2_Silent_p.L102L	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	102	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						GGAAGTCGCTCAGGGTGAGGA	0.607			NA											5	79					0	0	0.000602	0	0
MAL	4118	broad.mit.edu	37	2	95713808	95713808	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:95713808C>A	uc002stx.1	+	2	257	c.198C>A	c.(196-198)ACC>ACA	p.T66T	MAL_uc002sty.1_Intron|MAL_uc002stz.1_Silent_p.T66T|MAL_uc002sua.1_Intron	NM_002371	NP_002362	P21145	MAL_HUMAN	T-lymphocyte maturation-associated protein	66	Helical; (Potential).|MARVEL.				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath				0				STAD - Stomach adenocarcinoma(1183;0.18)		TCGTGGCCACCACCACCTTGA	0.627			NA											8	23					0.00307968	0.00357786	0.00308	1	0
ZNF2	7549	broad.mit.edu	37	2	95847751	95847751	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:95847751C>T	uc002suf.2	+	6	1637	c.1175C>T	c.(1174-1176)ACG>ATG	p.T392M	ZNF2_uc002sug.2_Missense_Mutation_p.T350M|ZNF2_uc010yue.1_Missense_Mutation_p.T355M|ZNF2_uc010fhs.2_Missense_Mutation_p.T313M	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CGTGTCCACACGGGAGAGAAG	0.507			NA											24	66					0	0	0.002299	0	0
ASTL	431705	broad.mit.edu	37	2	96795583	96795583	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:96795583C>A	uc010yui.1	-	8	854	c.854G>T	c.(853-855)GGC>GTC	p.G285V		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	285					proteolysis		metalloendopeptidase activity|zinc ion binding				0						GGGCCTGGGGCCACTTGGGCT	0.622			NA											12	45					5.50884e-06	7.37624e-06	0.001368	1	0
EIF5B	9669	broad.mit.edu	37	2	99976814	99976814	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:99976814C>T	uc002tab.2	+	2	335	c.151C>T	c.(151-153)CAG>TAG	p.Q51*		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	51					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						GAAAAAAAAGCAGGACTTTGA	0.323	Colon(162;2388 2567 2705 3444)		NA											5	27					0	0	0.000602	0	0
EIF5B	9669	broad.mit.edu	37	2	99988139	99988139	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:99988139G>A	uc002tab.2	+	9	1682	c.1498G>A	c.(1498-1500)GAT>AAT	p.D500N		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	500					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AGATACTGAGGATGCTGGATT	0.333	Colon(162;2388 2567 2705 3444)		NA											4	24					0	0	0.000602	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095483	103095483	+	Missense_Mutation	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:103095483A>C	uc002tbz.3	+	2	899	c.442A>C	c.(442-444)ACC>CCC	p.T148P		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	148	Helical; Name=D/M4; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CTTCATGCCCACCCGGCCCTT	0.592			NA											16	34					0	0	0.006122	0	0
BUB1	699	broad.mit.edu	37	2	111431931	111431931	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:111431931G>A	uc002tgc.2	-	2	150	c.38C>T	c.(37-39)GCC>GTC	p.A13V	BUB1_uc010yxh.1_Intron|BUB1_uc010fkb.2_Missense_Mutation_p.A13V|BUB1_uc002tgd.2_Missense_Mutation_p.A13V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	13	BUB1 N-terminal.|Necessary for kinetochore localization.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		CTGCATGTGGGCTTCAAGCAT	0.378			NA											14	38					0	0	0.00499	0	0
IL1B	3553	broad.mit.edu	37	2	113588914	113588914	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:113588914G>T	uc002tii.1	-	6	639	c.552C>A	c.(550-552)TAC>TAA	p.Y184*	IL1B_uc002tih.1_Nonsense_Mutation_p.Y153*	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	184					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CGCAGGACAGGTACAGATTCT	0.463			NA											45	129					3.4345e-17	6.36211e-17	0.002852	1	0
IL1F7	27178	broad.mit.edu	37	2	113676314	113676314	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:113676314C>G	uc002tij.2	+	5	627	c.585C>G	c.(583-585)AAC>AAG	p.N195K	IL1F7_uc002tik.2_Missense_Mutation_p.N174K|IL1F7_uc002til.2_Missense_Mutation_p.N155K|IL1F7_uc002tim.2_Missense_Mutation_p.N134K|IL1F7_uc002tin.2_Missense_Mutation_p.N169K	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	195					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						AATTTGAGAACAGGAAACACA	0.498			NA											8	35					0	0	0.00308	0	0
MKI67IP	84365	broad.mit.edu	37	2	122488549	122488549	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:122488549C>G	uc002tnk.2	-	4	561	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	MKI67IP_uc010fls.2_Missense_Mutation_p.E162Q	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	162					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						AATCGCTCCTCCATCCGTAGC	0.343			NA											5	130					0	0	0.000602	0	0
TSN	7247	broad.mit.edu	37	2	122519027	122519027	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:122519027C>G	uc002tnl.2	+	4	535	c.300C>G	c.(298-300)TTC>TTG	p.F100L	TSN_uc002tnm.2_Missense_Mutation_p.F53L|TSN_uc010yze.1_Missense_Mutation_p.F100L|TSN_uc010flt.2_Intron	NM_004622	NP_004613	Q15631	TSN_HUMAN	translin	100					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			breast(2)|large_intestine(1)	3		Ovarian(717;0.0563)|Prostate(154;0.116)				GCTTGGTCTTCTTGGCAGCAT	0.428			NA											3	126					0	0	0.004672	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125284963	125284963	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:125284963A>T	uc002tno.2	+	10	1940	c.1576A>T	c.(1576-1578)ATT>TTT	p.I526F	CNTNAP5_uc010flu.2_Missense_Mutation_p.I527F	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	526	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CAAGGACCTCATTTCAGTTCA	0.438			NA											13	87					0	0	0.001368	0	0
SAP130	79595	broad.mit.edu	37	2	128707786	128707786	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:128707786C>G	uc002tpp.2	-	16	2724	c.2592G>C	c.(2590-2592)AAG>AAC	p.K864N	SAP130_uc002tpn.2_Missense_Mutation_p.K624N|SAP130_uc002tpo.2_Missense_Mutation_p.K644N|SAP130_uc010fmd.2_Missense_Mutation_p.K899N	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	864	Interactions with SIN3A and HDAC1.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CCAGAAGACTCTTGGCAGTGG	0.468			NA											11	163					0	0	0.001368	0	0
TUBA3E	112714	broad.mit.edu	37	2	130951770	130951770	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:130951770G>T	uc002tqv.2	-	4	746	c.645C>A	c.(643-645)CGC>CGA	p.R215R		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	215					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					TGTCCAGGTTGCGCCGACATA	0.547			NA											15	53					7.93312e-07	1.1075e-06	0.00245	1	0
TUBA3E	112714	broad.mit.edu	37	2	130951938	130951938	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:130951938C>A	uc002tqv.2	-	4	578	c.477G>T	c.(475-477)GTG>GTT	p.V159V		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	159					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					TGCTGTAATCCACTGAGAGCC	0.582			NA											23	64					7.88262e-20	1.51018e-19	0.00333	1	0
TUBA3D	113457	broad.mit.edu	37	2	132237911	132237911	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:132237911C>A	uc002tsu.3	+	4	752	c.645C>A	c.(643-645)CGC>CGA	p.R215R		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	215					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TATGTCGGCGCAACCTGGACA	0.547	Ovarian(137;2059 2432 35543 39401)		NA											8	175					0.00244969	0.00286082	0.00245	1	0
MGAT5	4249	broad.mit.edu	37	2	135206372	135206372	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:135206372G>T	uc002ttv.1	+	16	2325	c.2180G>T	c.(2179-2181)CGG>CTG	p.R727L	LOC151162_uc002ttw.3_5'Flank	NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	727	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)		TGCCCCTGCCGGGACTTCATC	0.602			NA											12	37					4.3838e-07	6.19079e-07	0.001855	1	0
YSK4	80122	broad.mit.edu	37	2	135744958	135744958	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:135744958G>T	uc002tue.1	-	7	1515	c.1484C>A	c.(1483-1485)CCC>CAC	p.P495H	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.P382H|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.P223H|YSK4_uc002tui.3_Missense_Mutation_p.P512H	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	495							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGGTTCCTTGGGGCTTCCATC	0.428			NA											21	55					1.50039e-11	2.49693e-11	0.001882	1	0
THSD7B	80731	broad.mit.edu	37	2	138169276	138169276	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:138169276T>A	uc002tva.1	+	13	2700	c.2700T>A	c.(2698-2700)TAT>TAA	p.Y900*	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Nonsense_Mutation_p.Y790*	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCCAACCTTATGGAAACTGGT	0.483			NA											27	104					0	0	0.003954	0	0
LRP1B	53353	broad.mit.edu	37	2	141773396	141773396	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:141773396G>T	uc002tvj.1	-	13	3031	c.2059C>A	c.(2059-2061)CAG>AAG	p.Q687K	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	687	Extracellular (Potential).|LDL-receptor class B 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAAAAATCTGCCGATTGAAT	0.423	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			12	55					5.16669e-11	8.46202e-11	0.000978	1	0
TNFAIP6	7130	broad.mit.edu	37	2	152220468	152220468	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:152220468G>A	uc002txk.2	+	2	182	c.106G>A	c.(106-108)GGT>AGT	p.G36S		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	36	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		ACGAGCAGCCGGTGTGTACCA	0.483			NA											4	55					0	0	0.001168	0	0
PLA2R1	22925	broad.mit.edu	37	2	160806229	160806229	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:160806229T>A	uc002ube.1	-	25	3806	c.3599A>T	c.(3598-3600)GAT>GTT	p.D1200V	PLA2R1_uc010zcp.1_Missense_Mutation_p.D1200V|PLA2R1_uc002ubf.2_Missense_Mutation_p.D1200V	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1200	Extracellular (Potential).|C-type lectin 7.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GGACTCCTCATCTTTCCAAAA	0.493			NA											14	44					0	0	0.004007	0	0
ITGB6	3694	broad.mit.edu	37	2	160964216	160964216	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:160964216C>G	uc002ubh.2	-	14	2258	c.2242G>C	c.(2242-2244)GAA>CAA	p.E748Q	ITGB6_uc010fou.2_Missense_Mutation_p.E748Q|ITGB6_uc010zcq.1_Missense_Mutation_p.E706Q|ITGB6_uc010fov.1_Missense_Mutation_p.E748Q	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	748	Cytoplasmic (Potential).|Interaction with HAX1.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TTTGATCGTTCTGCTTCAAAT	0.478			NA											7	118					0	0	0.00308	0	0
FIGN	55137	broad.mit.edu	37	2	164467883	164467883	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:164467883C>A	uc002uck.1	-	3	770	c.459G>T	c.(457-459)GGG>GGT	p.G153G		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	153						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TGCTGGCTACCCCAGGAGAGC	0.527			NA											10	72					0.000442599	0.000529778	0.006214	1	0
SCN2A	6326	broad.mit.edu	37	2	166229750	166229750	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:166229750T>A	uc002udc.2	+	21	4155	c.3865T>A	c.(3865-3867)TTA>ATA	p.L1289I	SCN2A_uc002udd.2_Missense_Mutation_p.L1289I|SCN2A_uc002ude.2_Missense_Mutation_p.L1289I	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1289	III.|Helical; Name=S3 of repeat III; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACTGGTTAGCTTAACTGCAAA	0.403			NA											27	95					0	0	0.001786	0	0
SCN2A	6326	broad.mit.edu	37	2	166246119	166246119	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:166246119G>T	uc002udc.2	+	27	6093	c.5803G>T	c.(5803-5805)GAC>TAC	p.D1935Y	SCN2A_uc002udd.2_Missense_Mutation_p.D1935Y|SCN2A_uc002ude.2_Missense_Mutation_p.D1935Y	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1935					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATACAAGAAAGACAAAGGCAA	0.388			NA											11	65					4.68919e-08	6.92803e-08	0.008291	1	0
XIRP2	129446	broad.mit.edu	37	2	168103862	168103862	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:168103862C>A	uc002udx.2	+	8	5978	c.5960C>A	c.(5959-5961)GCG>GAG	p.A1987E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A1812E|XIRP2_uc010fpq.2_Missense_Mutation_p.A1765E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1812					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTTGAGCCAGCGGCCAAGTGG	0.463			NA											5	36					0.000602214	0.000715729	0.000602	1	0
XIRP2	129446	broad.mit.edu	37	2	168103880	168103880	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:168103880G>A	uc002udx.2	+	8	5996	c.5978G>A	c.(5977-5979)GGA>GAA	p.G1993E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G1818E|XIRP2_uc010fpq.2_Missense_Mutation_p.G1771E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1818					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGGCAAGGGGGAGCAGATACT	0.458			NA											12	30					0	0	0.001855	0	0
XIRP2	129446	broad.mit.edu	37	2	168104711	168104711	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:168104711C>G	uc002udx.2	+	8	6827	c.6809C>G	c.(6808-6810)TCC>TGC	p.S2270C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S2095C|XIRP2_uc010fpq.2_Missense_Mutation_p.S2048C|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2095					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATGGAAAGGTCCTTGAATCCA	0.428			NA											10	41					0	0	0.008291	0	0
LRP2	4036	broad.mit.edu	37	2	170058194	170058194	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:170058194A>T	uc002ues.2	-	44	8609	c.8396T>A	c.(8395-8397)ATC>AAC	p.I2799N		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2799	LDL-receptor class A 18.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCATTGCAGATAAACTCACG	0.438			NA											13	43					0	0	0.00245	0	0
LRP2	4036	broad.mit.edu	37	2	170092507	170092507	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:170092507A>T	uc002ues.2	-	29	4976	c.4763T>A	c.(4762-4764)ATG>AAG	p.M1588K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1588	LDL-receptor class B 12.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GACAGTGCGCATGCTGCCGTC	0.522			NA											8	31					0	0	0.008291	0	0
KBTBD10	10324	broad.mit.edu	37	2	170367183	170367183	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:170367183G>A	uc002ueu.1	+	1	972	c.895G>A	c.(895-897)GGA>AGA	p.G299R	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	299					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						TCCCAGGCATGGAATGTTTGT	0.473			NA											12	62					0	0	0.000978	0	0
FASTKD1	79675	broad.mit.edu	37	2	170403179	170403179	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:170403179G>C	uc002uev.3	-	8	1638	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.S403C	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	417					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						GACCAGAACAGACACCTCAGT	0.373			NA											3	64					0	0	0.004672	0	0
FASTKD1	79675	broad.mit.edu	37	2	170417034	170417034	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:170417034T>C	uc002uev.3	-	5	1222	c.834A>G	c.(832-834)CTA>CTG	p.L278L	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Silent_p.L264L|FASTKD1_uc002uey.2_Silent_p.L241L	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	278					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TATTAAATTGTAGAAATTTGT	0.284			NA											22	70					0	0	0.00278	0	0
ITGA6	3655	broad.mit.edu	37	2	173352066	173352066	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:173352066C>A	uc002uhp.1	+	15	2248	c.2045C>A	c.(2044-2046)CCT>CAT	p.P682H	ITGA6_uc010zdy.1_Missense_Mutation_p.P563H|ITGA6_uc002uho.1_Missense_Mutation_p.P682H|ITGA6_uc010fqm.1_Missense_Mutation_p.P328H	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	721	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			ACAAACAGCCCTTCCAACCCA	0.378			NA											8	66					0.00307968	0.00357786	0.00308	1	0
ZAK	51776	broad.mit.edu	37	2	174131331	174131332	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:174131331_174131332TG>CT	uc002uhz.2	+	20	2456_2457	c.2256_2257TG>CT	c.(2254-2259)ACTGAC>ACCTAC	p.D753Y	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	753					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			ACCCTGAGACTGACTCAAGAGC	0.554			NA											13	40					0	0	0.004672	0	0
HOXD1	3231	broad.mit.edu	37	2	177054838	177054838	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:177054838G>T	uc002ukv.3	+	2	1178	c.955G>T	c.(955-957)GGC>TGC	p.G319C	HOXD1_uc010fqy.2_3'UTR|HOXD1_uc010zez.1_Missense_Mutation_p.G319C	NM_024501	NP_078777	Q9GZZ0	HXD1_HUMAN	homeobox D1	319						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		CAAGAACCCCGGCAGCCCTTC	0.587			NA											10	54					9.70103e-10	1.53276e-09	0.008291	1	0
TTN	7273	broad.mit.edu	37	2	179466465	179466465	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179466465C>A	uc010zfg.1	-	235	47872	c.47648G>T	c.(47647-47649)CGA>CTA	p.R15883L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9578L|TTN_uc010zfi.1_Missense_Mutation_p.R9511L|TTN_uc010zfj.1_Missense_Mutation_p.R9386L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATGAGATCGTTTACACTC	0.363			NA											18	99					1.33834e-09	2.09242e-09	0.007413	1	0
TTN	7273	broad.mit.edu	37	2	179472235	179472235	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179472235G>T	uc010zfg.1	-	226	45700	c.45476C>A	c.(45475-45477)TCT>TAT	p.S15159Y	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S8854Y|TTN_uc010zfi.1_Missense_Mutation_p.S8787Y|TTN_uc010zfj.1_Missense_Mutation_p.S8662Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16086							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTAGTTCAGATTTGGTTCC	0.448			NA											10	421					1.58986e-06	2.20122e-06	0.008291	1	0
TTN	7273	broad.mit.edu	37	2	179594220	179594220	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179594220T>A	uc010zfg.1	-	61	15155	c.14931A>T	c.(14929-14931)GAA>GAT	p.E4977D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1638D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5904							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCCGTAACTTCACACTCCA	0.443			NA											36	86					0	0	0.005524	0	0
TTN	7273	broad.mit.edu	37	2	179640809	179640809	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179640809C>G	uc010zfg.1	-	28	6006	c.5782G>C	c.(5782-5784)GAG>CAG	p.E1928Q	TTN_uc010zfh.1_Missense_Mutation_p.E1882Q|TTN_uc010zfi.1_Missense_Mutation_p.E1882Q|TTN_uc010zfj.1_Missense_Mutation_p.E1882Q|TTN_uc002unb.2_Missense_Mutation_p.E1928Q|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1928							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTGAATCTCAAGCTTCACT	0.458			NA											5	229					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179658174	179658174	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179658174A>T	uc010zfg.1	-	9	1717	c.1493T>A	c.(1492-1494)GTA>GAA	p.V498E	TTN_uc010zfh.1_Missense_Mutation_p.V498E|TTN_uc010zfi.1_Missense_Mutation_p.V498E|TTN_uc010zfj.1_Missense_Mutation_p.V498E|TTN_uc002unb.2_Missense_Mutation_p.V498E|TTN_uc010frg.1_Missense_Mutation_p.V172E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	498							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGGTAATTACTTCTTTGGT	0.413			NA											10	99					0	0	0.000978	0	0
SESTD1	91404	broad.mit.edu	37	2	179979965	179979965	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179979965T>A	uc002uni.3	-	16	1816	c.1666A>T	c.(1666-1668)AGG>TGG	p.R556W	SESTD1_uc002unh.3_Missense_Mutation_p.R59W	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	556	Spectrin 3.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGCAACTGCCTGCCATAGTCA	0.418			NA											6	16					0	0	0.001168	0	0
PDE1A	5136	broad.mit.edu	37	2	183053759	183053759	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:183053759G>T	uc002uos.2	-	12	1286	c.1202C>A	c.(1201-1203)CCA>CAA	p.P401Q	PDE1A_uc010zfp.1_Missense_Mutation_p.P297Q|PDE1A_uc002uoq.1_Missense_Mutation_p.P401Q|PDE1A_uc010zfq.1_Missense_Mutation_p.P401Q|PDE1A_uc002uor.2_Missense_Mutation_p.P385Q|PDE1A_uc002uou.2_Missense_Mutation_p.P367Q	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	401	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TGGGGAAAATGGAAGCCCTAA	0.408			NA											43	117					5.20837e-25	1.02413e-24	0.00874	1	0
ZNF804A	91752	broad.mit.edu	37	2	185731213	185731213	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:185731213A>G	uc002uph.2	+	2	823	c.229A>G	c.(229-231)AAT>GAT	p.N77D		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	77	C2H2-type.					intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAATCACATTAATTCATATGA	0.358			NA											8	48					0	0	0.004482	0	0
FAM171B	165215	broad.mit.edu	37	2	187627079	187627079	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:187627079C>A	uc002ups.2	+	8	2122	c.2010C>A	c.(2008-2010)CCC>CCA	p.P670P	FAM171B_uc002upr.1_Silent_p.P637P|FAM171B_uc002upt.2_Silent_p.P139P	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	670	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						CCCCGCATCCCAGAGCCTGGT	0.483			NA											25	95					7.87624e-14	1.38634e-13	0.00278	1	0
COL5A2	1290	broad.mit.edu	37	2	189917697	189917697	+	Silent	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:189917697T>A	uc002uqk.2	-	39	2876	c.2601A>T	c.(2599-2601)GGA>GGT	p.G867G	COL5A2_uc010frx.2_Silent_p.G443G	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	867					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CTCCCTTCTGTCCTGGCTCTC	0.433			NA											12	38					0	0	0.00245	0	0
STAT4	6775	broad.mit.edu	37	2	191895766	191895766	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:191895766G>A	uc002usm.1	-	23	2406	c.2152C>T	c.(2152-2154)CTT>TTT	p.L718F	STAT4_uc002usn.1_Missense_Mutation_p.L718F	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	718					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GACATGGGAAGAAGGTCTGAT	0.403			NA											7	212					0	0	0.004482	0	0
SATB2	23314	broad.mit.edu	37	2	200136964	200136964	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:200136964C>T	uc002uuy.1	-	11	2989	c.2172G>A	c.(2170-2172)AAG>AAA	p.K724K	SATB2_uc010fsq.1_Silent_p.K606K|SATB2_uc002uuz.1_Silent_p.K724K|SATB2_uc002uva.1_Silent_p.K724K	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	724						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAGGTGCTGCCTTGCTTTTGT	0.468	Colon(30;262 767 11040 24421 36230)		NA											19	94					0	0	0.007413	0	0
NRP2	8828	broad.mit.edu	37	2	206659578	206659578	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:206659578C>A	uc002vaw.2	+	17	3383	c.2592C>A	c.(2590-2592)CCC>CCA	p.P864P	NRP2_uc002vax.2_Silent_p.P859P|NRP2_uc002vay.2_Silent_p.P842P	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	864	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CCCTGGATCCCATCCTCATCA	0.587			NA											13	72					1.5842e-08	2.38251e-08	0.001855	1	0
CPS1	1373	broad.mit.edu	37	2	211525226	211525226	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:211525226G>T	uc002vee.3	+	32	3906	c.3774G>T	c.(3772-3774)TTG>TTT	p.L1258F	CPS1_uc010fur.2_Missense_Mutation_p.L1264F|CPS1_uc010fus.2_Missense_Mutation_p.L807F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1258	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AGTGTAACTTGAGAGCTTCTC	0.403			NA											37	149					5.04308e-16	9.18976e-16	0.00623	1	0
RUFY4	285180	broad.mit.edu	37	2	218947967	218947967	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:218947967T>C	uc002vgw.2	+	12	2815	c.971T>C	c.(970-972)TTG>TCG	p.L324S	RUFY4_uc002vgy.1_RNA|RUFY4_uc010fvl.1_Missense_Mutation_p.L324S	NM_198483	NP_940885	Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	497	FYVE-type.						metal ion binding			pancreas(1)	1		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGCGGGTGTTGGAACTGATC	0.582			NA											8	48					0	0	0.004482	0	0
C2orf24	27013	broad.mit.edu	37	2	220039790	220039790	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:220039790C>A	uc002vju.3	-	4	453	c.301G>T	c.(301-303)GTG>TTG	p.V101L	C2orf24_uc002vjv.2_Missense_Mutation_p.V101L	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	101					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAATGTACACCAGAGCCAGC	0.517			NA											20	40					1.56452e-12	2.64963e-12	0.007413	1	0
DNAJB2	3300	broad.mit.edu	37	2	220149365	220149365	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:220149365G>T	uc002vkx.1	+	9	868	c.631G>T	c.(631-633)GAC>TAC	p.D211Y	DNAJB2_uc002vkw.1_Missense_Mutation_p.D211Y|DNAJB2_uc002vky.2_Missense_Mutation_p.D27Y|DNAJB2_uc010zlb.1_Missense_Mutation_p.D27Y	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	211	UIM 1.				ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTCCCAGATGACCTGGCACT	0.622			NA											11	32					0.00829132	0.00946874	0.008291	1	0
ACCN4	55515	broad.mit.edu	37	2	220401832	220401832	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:220401832C>G	uc002vma.2	+	6	1612	c.1598C>G	c.(1597-1599)TCT>TGT	p.S533C	ACCN4_uc002vlz.2_Missense_Mutation_p.S552C|ACCN4_uc002vmb.2_Missense_Mutation_p.S206C	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	533	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		GCCCTGACCTCTGAAGCCATG	0.627			NA											4	51					0	0	0.000602	0	0
SCG2	7857	broad.mit.edu	37	2	224463909	224463909	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:224463909T>G	uc002vnm.2	-	2	225	c.92A>C	c.(91-93)CAG>CCG	p.Q31P		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	31					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CTGGTTTCTCTGAAATGAAGC	0.458			NA											4	103					0	0	0.000248	0	0
SLC19A3	80704	broad.mit.edu	37	2	228560738	228560738	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:228560738G>C	uc002vpi.2	-	4	1128	c.1039C>G	c.(1039-1041)CTG>GTG	p.L347V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.L343V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	347	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	ACCAGAGCCAGCTCTCCCAGA	0.448			NA											23	45					0	0	0.002299	0	0
GPR55	9290	broad.mit.edu	37	2	231775329	231775329	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:231775329T>G	uc002vrg.2	-	2	542	c.349A>C	c.(349-351)ATG>CTG	p.M117L	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.M117L	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	117	Cytoplasmic (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		AACCGGTCCATGCTGATGAAG	0.592			NA											11	28					0	0	0.001368	0	0
UGT1A5	54579	broad.mit.edu	37	2	234677057	234677057	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:234677057G>T	uc002vuw.2	+	4	1279	c.1279G>T	c.(1279-1281)GCT>TCT	p.A427S	UGT1A8_uc010zmv.1_Missense_Mutation_p.A423S|UGT1A8_uc002vup.2_Missense_Mutation_p.A423S|UGT1A10_uc002vuq.3_Missense_Mutation_p.A423S|UGT1A10_uc002vur.2_Missense_Mutation_p.A423S|UGT1A9_uc010zmw.1_Missense_Mutation_p.A423S|UGT1A9_uc002vus.2_Missense_Mutation_p.A423S|UGT1A7_uc010zmx.1_Missense_Mutation_p.A423S|UGT1A7_uc002vut.2_Missense_Mutation_p.A423S|UGT1A6_uc002vuu.2_Missense_Mutation_p.A158S|UGT1A6_uc010zmy.1_Missense_Mutation_p.A425S|UGT1A6_uc002vuv.3_Missense_Mutation_p.A425S|UGT1A5_uc010zmz.1_Missense_Mutation_p.A427S|UGT1A4_uc010zna.1_Missense_Mutation_p.A427S|UGT1A4_uc002vux.2_Missense_Mutation_p.A427S|UGT1A3_uc010znb.1_Missense_Mutation_p.A427S|UGT1A3_uc002vuy.2_Missense_Mutation_p.A427S|UGT1A9_uc002vva.2_RNA|UGT1A1_uc010znc.1_Missense_Mutation_p.A426S|UGT1A1_uc002vvb.2_Missense_Mutation_p.A426S	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	427					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		TTTAGAAAATGCTCTAAAAGC	0.368			NA											5	19					1.024e-07	1.49157e-07	0.000602	1	0
GBX2	2637	broad.mit.edu	37	2	237076108	237076108	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:237076108C>T	uc002vvw.1	-	1	545	c.507G>A	c.(505-507)ACG>ACA	p.T169T	GBX2_uc010zng.1_Silent_p.T159T	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	169				LPPAHPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSA SPQHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFL AKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKG -> CRPHTLTTRSPACPQASAPAWRRAWRSPLRSWPRSPAA SPRRPSTRRRQRPASSRRSRCPAAVTSTRRRRCRLTRRTAK ASWPKRARCSPSPRPRRCRLRSSGLSEGKGKTSQRWKTTRS (in Ref. 1; AAC03241).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		AAGCCTGCACCGTCTCGGCCG	0.736			NA											6	9					0	0	0.00308	0	0
COL6A3	1293	broad.mit.edu	37	2	238305434	238305434	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:238305434T>A	uc002vwl.2	-	2	312	c.27A>T	c.(25-27)TTA>TTT	p.L9F	COL6A3_uc002vwo.2_Missense_Mutation_p.L9F|COL6A3_uc010znj.1_Missense_Mutation_p.L9F|COL6A3_uc002vwq.2_Missense_Mutation_p.L9F|COL6A3_uc002vwr.2_Missense_Mutation_p.L9F|COL6A3_uc010znk.1_Missense_Mutation_p.L9F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	9					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGACGGCCACTAAGGGCAAGT	0.438			NA											19	46					0	0	0.007413	0	0
RAMP1	10267	broad.mit.edu	37	2	238785925	238785925	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:238785925G>T	uc002vxj.2	+	2	244	c.112G>T	c.(112-114)GAG>TAG	p.E38*		NM_005855	NP_005846	O60894	RAMP1_HUMAN	receptor activity-modifying protein 1 precursor	38	Extracellular (Potential).				intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity				0		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	CCTCCTCCGGGAGCTCTGCCT	0.627	NSCLC(177;211 2889 43936 50767)		NA											9	61					3.86212e-05	4.87942e-05	0.008291	1	0
TRAF3IP1	26146	broad.mit.edu	37	2	239237914	239237914	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:239237914G>C	uc002vye.2	+	5	965	c.846G>C	c.(844-846)GTG>GTC	p.V282V	TRAF3IP1_uc002vyf.2_Silent_p.V282V	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	282	Abolishes microtubules-binding when missing.|DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		gacggagagtgaaaaacgggg	0.219			NA											4	49					0	0	0.000602	0	0
OR6B2	389090	broad.mit.edu	37	2	240969652	240969653	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:240969652_240969653GG>TT	uc002vyr.2	-	2	240_241	c.194_195CC>AA	c.(193-195)TCC>TAA	p.S65*	OR6B2_uc010zoc.1_Nonsense_Mutation_p.S65*	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GGAAAGACATGGAGCTCAGAAA	0.554			NA											13	84					0	0	0.004672	0	0
HDLBP	3069	broad.mit.edu	37	2	242195624	242195624	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:242195624C>T	uc002waz.2	-	7	1076	c.848G>A	c.(847-849)CGC>CAC	p.R283H	HDLBP_uc002wba.2_Missense_Mutation_p.R283H|HDLBP_uc002wbb.2_Missense_Mutation_p.R304H|HDLBP_uc010fzn.1_Missense_Mutation_p.R35H	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	283	KH 2.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CTTCTTGATGCGAGCCACAGC	0.512			NA											7	54					0	0	0.001984	0	0
ING5	84289	broad.mit.edu	37	2	242650848	242650848	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:242650848G>A	uc002wcd.2	+	4	358	c.333G>A	c.(331-333)CTG>CTA	p.L111L	ING5_uc002wcc.1_Silent_p.L111L	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	111					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		AAGCAGATCTGAAGGACAAGA	0.383			NA											6	188					0	0	0.004482	0	0
D2HGDH	728294	broad.mit.edu	37	2	242690681	242690681	+	Missense_Mutation	SNP	A	A	G	rs149383887	by1000genomes	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:242690681A>G	uc002wce.1	+	8	1191	c.1018A>G	c.(1018-1020)ATC>GTC	p.I340V	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.I206V|D2HGDH_uc002wcg.1_Intron|D2HGDH_uc002wch.2_Intron|D2HGDH_uc002wci.2_Missense_Mutation_p.I39V	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	340					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTACGTCCTCATCGAGACTTC	0.622			NA											15	30					0	0	0.00499	0	0
PRND	23627	broad.mit.edu	37	20	4705237	4705237	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:4705237T>A	uc002wkz.2	+	2	111	c.40T>A	c.(40-42)TGC>AGC	p.C14S		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	14					protein homooligomerization	anchored to membrane|plasma membrane					0						GGCCACTGTCTGCATGCTGCT	0.632			NA											18	39					0	0	0.007413	0	0
NINL	22981	broad.mit.edu	37	20	25472120	25472120	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:25472120C>A	uc002wux.1	-	11	1426	c.1352G>T	c.(1351-1353)CGG>CTG	p.R451L	NINL_uc010gdn.1_Missense_Mutation_p.R451L|NINL_uc010gdo.1_Missense_Mutation_p.R234L|NINL_uc010ztf.1_Missense_Mutation_p.R467L	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	451					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CACCTCAGACCGCAGGAGGCT	0.657			NA											18	79					1.33834e-09	2.09242e-09	0.007413	1	0
NINL	22981	broad.mit.edu	37	20	25491358	25491358	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:25491358C>G	uc002wux.1	-	5	543	c.469G>C	c.(469-471)GAG>CAG	p.E157Q	NINL_uc010gdn.1_Missense_Mutation_p.E157Q|NINL_uc010gdo.1_5'UTR|NINL_uc010ztf.1_Missense_Mutation_p.E173Q	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	157					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTCTCGGCCTCTTCATCTGAC	0.512			NA											3	109					0	0	0.004672	0	0
DEFB121	245934	broad.mit.edu	37	20	29992817	29992817	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:29992817A>G	uc002wvv.1	-	2	166	c.130T>C	c.(130-132)TGC>CGC	p.C44R		NM_001011878	NP_001011878	Q5J5C9	DB121_HUMAN	defensin, beta 121 precursor	44					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TCAGTTTTGCATAATATATAG	0.388			NA											10	46					0	0	0.008291	0	0
MYLK2	85366	broad.mit.edu	37	20	30411373	30411373	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:30411373A>T	uc002wwq.2	+	5	968	c.866A>T	c.(865-867)GAG>GTG	p.E289V		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	289	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AACTCCAAGGAGGCGCTCGGA	0.617			NA									OREG0025856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	55					0	0	0.003163	0	0
HCK	3055	broad.mit.edu	37	20	30659562	30659562	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:30659562G>T	uc002wxh.2	+	2	331	c.160G>T	c.(160-162)GAT>TAT	p.D54Y	HCK_uc010gdy.2_Missense_Mutation_p.D33Y|HCK_uc002wxi.2_Missense_Mutation_p.D33Y	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	54					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTACGTGCCGGATCCCACATC	0.577			NA											5	19					1.23904e-05	1.62503e-05	0.000602	1	0
KIF3B	9371	broad.mit.edu	37	20	30898583	30898583	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:30898583A>T	uc002wxq.2	+	2	1170	c.1003A>T	c.(1003-1005)AAC>TAC	p.N335Y	KIF3B_uc010ztv.1_Missense_Mutation_p.N335Y|KIF3B_uc010ztw.1_Missense_Mutation_p.N335Y	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	335	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCGATATGCCAACCGTGCCAA	0.527			NA											11	49					0	0	0.001368	0	0
PLUNC	51297	broad.mit.edu	37	20	31827694	31827694	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:31827694G>A	uc002wyv.2	+	4	476	c.406G>A	c.(406-408)GGC>AGC	p.G136S	PLUNC_uc002wyt.3_Missense_Mutation_p.G136S|PLUNC_uc002wyu.3_Missense_Mutation_p.G136S	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	136					innate immune response	extracellular region	lipid binding				0						CATCCCTCTCGGCATAAAGCT	0.458			NA											39	100					0	0	0.00623	0	0
GDF5	8200	broad.mit.edu	37	20	34021970	34021970	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:34021970C>A	uc002xck.1	-	2	1562	c.1243G>T	c.(1243-1245)GAC>TAC	p.D415Y	GDF5_uc010gfc.1_Missense_Mutation_p.D415Y|uc002xcj.2_Silent_p.V127V|GDF5_uc010zvc.1_Missense_Mutation_p.D415Y	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	415					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			ATCCAGTCGTCCCAGCCCATG	0.612			NA											23	54					1.96895e-08	2.93811e-08	0.00278	1	0
NDRG3	57446	broad.mit.edu	37	20	35350115	35350115	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:35350115C>A	uc002xfw.2	-	2	106	c.24G>T	c.(22-24)CAG>CAT	p.Q8H	NDRG3_uc002xfx.2_Missense_Mutation_p.Q8H|NDRG3_uc010zvq.1_5'UTR|NDRG3_uc010zvr.1_5'UTR	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	8					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				TCTCTGTGAGCTGAACATCCT	0.343			NA											15	39					5.01169e-05	6.31398e-05	0.00499	1	0
HNF4A	3172	broad.mit.edu	37	20	43034763	43034763	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:43034763G>C	uc002xma.2	+	2	270	c.181G>C	c.(181-183)GCC>CCC	p.A61P	HNF4A_uc010zwo.1_Silent_p.V51V|HNF4A_uc002xlt.2_Missense_Mutation_p.A39P|HNF4A_uc002xlu.2_Missense_Mutation_p.A39P|HNF4A_uc002xlv.2_Missense_Mutation_p.A39P|HNF4A_uc002xly.2_Missense_Mutation_p.A61P|HNF4A_uc002xlz.2_Missense_Mutation_p.A61P|HNF4A_uc010ggq.2_Missense_Mutation_p.A54P	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	61	Nuclear receptor.|NR C4-type.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGCCCTGTGTGCCATCTGCGG	0.632	Colon(79;2 1269 8820 14841 52347)		NA											13	123					0	0	0.001855	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505942	44505942	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:44505942G>C	uc002xqd.2	+	2	948	c.745G>C	c.(745-747)GTG>CTG	p.V249L	ZSWIM3_uc010zxg.1_Missense_Mutation_p.V243L	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	249							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				AAGTCGAGTGGTGCACTTTGC	0.542			NA											20	53					0	0	0.001523	0	0
PREX1	57580	broad.mit.edu	37	20	47267939	47267939	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:47267939C>A	uc002xtw.1	-	22	2673	c.2650G>T	c.(2650-2652)GCC>TCC	p.A884S	PREX1_uc002xtv.1_Missense_Mutation_p.A181S	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	884					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GAGACCTTGGCGGTGAGGCCG	0.617			NA											7	29					1.06961e-07	1.55129e-07	0.00308	1	0
PREX1	57580	broad.mit.edu	37	20	47273692	47273692	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:47273692G>T	uc002xtw.1	-	18	2032	c.2009C>A	c.(2008-2010)TCC>TAC	p.S670Y	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	670	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCATTGATGGAGTAGATCTT	0.617			NA									OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0.000602214	0.000715729	0.000602	1	0
KCNG1	3755	broad.mit.edu	37	20	49626434	49626434	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:49626434G>T	uc002xwa.3	-	2	737	c.442C>A	c.(442-444)CAG>AAG	p.Q148K	KCNG1_uc002xwb.2_Missense_Mutation_p.Q148K	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	148	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						AGCTCCTCCTGGAAGGACAGC	0.652			NA											16	29					9.16793e-09	1.38968e-08	0.00499	1	0
ATP9A	10079	broad.mit.edu	37	20	50292705	50292705	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:50292705C>A	uc002xwg.1	-	10	842	c.842G>T	c.(841-843)CGG>CTG	p.R281L	ATP9A_uc010gih.1_Missense_Mutation_p.R145L|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	281	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						CATGACACTCCGGAGTTCTCT	0.428			NA											10	35					2.17888e-05	2.81911e-05	0.006214	1	0
TSHZ2	128553	broad.mit.edu	37	20	51873022	51873022	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:51873022G>T	uc002xwo.2	+	2	3981	c.3025G>T	c.(3025-3027)GTA>TTA	p.V1009L		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	1009	C2H2-type 5.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CAAACATGCGGTAAAACTCCA	0.473			NA											23	73					2.89027e-11	4.77445e-11	0.002299	1	0
BCAS1	8537	broad.mit.edu	37	20	52645173	52645173	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:52645173C>A	uc002xws.2	-	4	819	c.481G>T	c.(481-483)GAC>TAC	p.D161Y	BCAS1_uc010zzb.1_Missense_Mutation_p.D64Y|BCAS1_uc010gim.2_Missense_Mutation_p.D64Y|BCAS1_uc002xwt.2_Missense_Mutation_p.D161Y|BCAS1_uc010gil.1_Missense_Mutation_p.D161Y|BCAS1_uc010zzc.1_Missense_Mutation_p.D64Y	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	161						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			AGGACCTTGTCTTGGGCCGGG	0.622			NA											8	57					1.12685e-05	1.48953e-05	0.004482	1	0
BCAS1	8537	broad.mit.edu	37	20	52645175	52645175	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:52645175T>G	uc002xws.2	-	4	817	c.479A>C	c.(478-480)CAA>CCA	p.Q160P	BCAS1_uc010zzb.1_Missense_Mutation_p.Q63P|BCAS1_uc010gim.2_Missense_Mutation_p.Q63P|BCAS1_uc002xwt.2_Missense_Mutation_p.Q160P|BCAS1_uc010gil.1_Missense_Mutation_p.Q160P|BCAS1_uc010zzc.1_Missense_Mutation_p.Q63P	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	160						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GACCTTGTCTTGGGCCGGGGC	0.622			NA											8	56					0	0	0.004482	0	0
CTCFL	140690	broad.mit.edu	37	20	56098847	56098847	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:56098847G>T	uc010gix.1	-	1	1077	c.415C>A	c.(415-417)CAG>AAG	p.Q139K	CTCFL_uc010giw.1_Missense_Mutation_p.Q139K|CTCFL_uc002xym.2_Missense_Mutation_p.Q139K|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Missense_Mutation_p.Q139K|CTCFL_uc010gjb.1_Missense_Mutation_p.Q139K|CTCFL_uc010gjc.1_Missense_Mutation_p.Q139K|CTCFL_uc010gjd.1_Missense_Mutation_p.Q139K|CTCFL_uc010gje.2_Missense_Mutation_p.Q139K|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Missense_Mutation_p.Q139K|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Missense_Mutation_p.Q139K|CTCFL_uc010gjk.1_Missense_Mutation_p.Q139K|CTCFL_uc010gjl.1_Missense_Mutation_p.Q139K	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	139					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AGCTCTTGCTGGATACTAATG	0.582			NA											27	91					3.73988e-18	7.04441e-18	0.00632	1	0
PCK1	5105	broad.mit.edu	37	20	56137200	56137200	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:56137200A>G	uc002xyn.3	+	3	461	c.298A>G	c.(298-300)AGA>GGA	p.R100G	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	100					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCAAGAGCAAAGAGACACAGT	0.547			NA											6	50					0	0	0.001984	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227368	56227368	+	Missense_Mutation	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:56227368A>C	uc002xyq.2	-	4	998	c.605T>G	c.(604-606)CTG>CGG	p.L202R	PMEPA1_uc002xyr.2_Missense_Mutation_p.L152R|PMEPA1_uc002xys.2_Missense_Mutation_p.L167R|PMEPA1_uc002xyt.2_Missense_Mutation_p.L152R	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	202	Cytoplasmic (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						GGGGCCGCCCAGCCTGGCACT	0.687			NA											9	41					0	0	0.008291	0	0
SS18L1	26039	broad.mit.edu	37	20	60737876	60737876	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:60737876G>T	uc002ycb.2	+	5	500	c.445G>T	c.(445-447)GGG>TGG	p.G149W	SS18L1_uc011aaa.1_Missense_Mutation_p.G149W|SS18L1_uc002ybz.1_RNA|SS18L1_uc002yca.1_RNA|SS18L1_uc002ycc.1_RNA	NM_198935	NP_945173	O75177	CREST_HUMAN	SS18-like protein 1	149	Methionine-rich intra-molecular domain (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore				ovary(2)	2	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			GAGCATCTCTGGGCCCGGCTA	0.662			NA	T	SSX1	synovial sarcoma								6	24					3.59834e-05	4.57629e-05	0.001168	1	0
SS18L1	26039	broad.mit.edu	37	20	60737878	60737878	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:60737878G>T	uc002ycb.2	+	5	502	c.447G>T	c.(445-447)GGG>GGT	p.G149G	SS18L1_uc011aaa.1_Silent_p.G149G|SS18L1_uc002ybz.1_RNA|SS18L1_uc002yca.1_RNA|SS18L1_uc002ycc.1_RNA	NM_198935	NP_945173	O75177	CREST_HUMAN	SS18-like protein 1	149	Methionine-rich intra-molecular domain (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore				ovary(2)	2	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			GCATCTCTGGGCCCGGCTACA	0.662			NA	T	SSX1	synovial sarcoma								6	24					3.59834e-05	4.57629e-05	0.001168	1	0
COL9A3	1299	broad.mit.edu	37	20	61453473	61453473	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr20:61453473G>T	uc002ydm.2	+	9	437	c.434G>T	c.(433-435)GGA>GTA	p.G145V		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	145	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					GGACCTTCTGGACTCCCCGGC	0.652			NA											12	51					9.31168e-06	1.24063e-05	0.001855	1	0
TPTE	7179	broad.mit.edu	37	21	10934082	10934082	+	Missense_Mutation	SNP	C	C	A	rs139617622		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:10934082C>A	uc002yip.1	-	16	1263	c.895G>T	c.(895-897)GTC>TTC	p.V299F	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V281F|TPTE_uc002yir.1_Missense_Mutation_p.V261F|TPTE_uc010gkv.1_Missense_Mutation_p.V161F	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	299	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTCTAACGACCCTATTATGG	0.328			NA											31	220					2.42023e-17	4.48946e-17	0.003271	1	0
CXADR	1525	broad.mit.edu	37	21	18924196	18924196	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:18924196G>C	uc002yki.2	+	3	458	c.340G>C	c.(340-342)GAT>CAT	p.D114H	CXADR_uc002ykh.1_Missense_Mutation_p.D114H|CXADR_uc010gld.1_Missense_Mutation_p.D114H|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Missense_Mutation_p.D87H	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	114	Extracellular (Potential).|Ig-like C2-type 1.				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		ACAACTGTCAGATATTGGCAC	0.348			NA											3	40					0	0	0.000602	0	0
CCT8	10694	broad.mit.edu	37	21	30441752	30441752	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:30441752C>G	uc002ynb.2	-	3	322	c.223G>C	c.(223-225)GAA>CAA	p.E75Q	CCT8_uc011acp.1_Missense_Mutation_p.E56Q|CCT8_uc002yna.2_Missense_Mutation_p.E24Q|CCT8_uc002ync.2_Missense_Mutation_p.E75Q|CCT8_uc010glm.2_Missense_Mutation_p.E75Q|CCT8_uc011acq.1_Intron	NM_006585	NP_006576	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	75					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding				0						ACTTCTAGTTCTCTTAAAATA	0.284			NA											5	52					0	0	0.001984	0	0
TIAM1	7074	broad.mit.edu	37	21	32526583	32526583	+	Silent	SNP	C	C	T	rs147935563	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:32526583C>T	uc002yow.1	-	18	3625	c.3153G>A	c.(3151-3153)ACG>ACA	p.T1051T	TIAM1_uc011adk.1_Silent_p.T1051T|TIAM1_uc011adl.1_Silent_p.T991T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1051	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AGGTGCGCTCCGTCTCCAGGA	0.557			NA											7	43					0	0	0.001984	0	0
WDR4	10785	broad.mit.edu	37	21	44283572	44283572	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:44283572T>G	uc002zci.2	-	4	504	c.431A>C	c.(430-432)CAC>CCC	p.H144P	WDR4_uc002zck.1_Missense_Mutation_p.H144P|WDR4_uc002zcl.1_5'UTR|WDR4_uc010gpg.1_Missense_Mutation_p.H144P|WDR4_uc011aew.1_5'UTR|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	144	WD 2.				tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CATAGACAGGTGCCCCAGCTC	0.607			NA											4	21					0	0	0.000248	0	0
TRPM2	7226	broad.mit.edu	37	21	45861640	45861640	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:45861640C>G	uc002zet.1	+	33	4665	c.4452C>G	c.(4450-4452)CTC>CTG	p.L1484L	TRPM2_uc002zeu.1_Silent_p.L1484L|TRPM2_uc002zew.1_Silent_p.L1484L|TRPM2_uc010gpt.1_Silent_p.L1534L|TRPM2_uc002zex.1_Silent_p.L1270L|TRPM2_uc002zey.1_Silent_p.L963L|TRPM2_uc011aff.1_Silent_p.L165L	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1484	Nudix hydrolase.|Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCATCCCACTCTATGCGAACC	0.642			NA											9	18					0	0	0.004482	0	0
POFUT2	23275	broad.mit.edu	37	21	46687515	46687515	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr21:46687515C>G	uc002zhc.2	-	8	1151	c.1126G>C	c.(1126-1128)GCA>CCA	p.A376P	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.A376P	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	376					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		CTGGCGTGTGCGCAGATCCAC	0.572			NA											16	69					0	0	0.004007	0	0
MICAL3	57553	broad.mit.edu	37	22	18304813	18304813	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:18304813G>A	uc002zng.3	-	24	3784	c.3431C>T	c.(3430-3432)CCG>CTG	p.P1144L	MICAL3_uc011agl.1_Missense_Mutation_p.P1060L	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1144	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TTGGTGCTTCGGTGAGGCGGG	0.582			NA											11	85					0	0	0.00245	0	0
CLTCL1	8218	broad.mit.edu	37	22	19175534	19175534	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:19175534C>G	uc002zpb.2	-	29	4468	c.4393G>C	c.(4393-4395)GAG>CAG	p.E1465Q	CLTCL1_uc011agv.1_Missense_Mutation_p.E1465Q|CLTCL1_uc011agw.1_Missense_Mutation_p.E1444Q|CLTCL1_uc011agt.1_Missense_Mutation_p.E256Q|CLTCL1_uc011agu.1_Intron	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1465	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTGAGTGCCTCATTCACACTC	0.597			NA	T	?	ALCL								9	152					0	0	0.006214	0	0
MYO18B	84700	broad.mit.edu	37	22	26423548	26423548	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:26423548C>A	uc003abz.1	+	43	7858	c.7608C>A	c.(7606-7608)GAC>GAA	p.D2536E	MYO18B_uc003aca.1_Missense_Mutation_p.D2417E|MYO18B_uc010guy.1_Missense_Mutation_p.D2418E|MYO18B_uc010guz.1_Missense_Mutation_p.D2416E|MYO18B_uc011aka.1_Missense_Mutation_p.D1690E|MYO18B_uc011akb.1_Missense_Mutation_p.D2049E|MYO18B_uc010gva.1_Missense_Mutation_p.D519E|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2536						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TTGCGGGTGACGGTGGCGAGC	0.567			NA											8	16					2.17888e-05	2.81911e-05	0.006214	1	0
SF3A1	10291	broad.mit.edu	37	22	30736319	30736319	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:30736319G>T	uc003ahl.2	-	9	1373	c.1241C>A	c.(1240-1242)CCC>CAC	p.P414H		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	414					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						CCCAGTAATGGGGGACACAAG	0.562			NA											31	37					1.99505e-19	3.8005e-19	0.002445	1	0
CSNK1E	1454	broad.mit.edu	37	22	38696770	38696770	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:38696770C>A	uc003avj.2	-	5	785	c.524G>T	c.(523-525)GGC>GTC	p.G175V	CSNK1E_uc003avk.2_Missense_Mutation_p.G175V|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.G175V|CSNK1E_uc003avo.2_Missense_Mutation_p.G175V|CSNK1E_uc003avp.1_Missense_Mutation_p.G175V|CSNK1E_uc003avq.1_Missense_Mutation_p.G175V	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	175	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					GCGGGCCGTGCCGGTCAGGTT	0.647	Esophageal Squamous(119;108 755 9651 12170 13692 17603 24932 28315 37982 41601)		NA											12	35					4.36969e-10	6.96144e-10	0.001855	1	0
RPL3	6122	broad.mit.edu	37	22	39709261	39709261	+	Missense_Mutation	SNP	T	T	C	rs150061768		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:39709261T>C	uc003axi.2	-	9	1170	c.1102A>G	c.(1102-1104)ATT>GTT	p.I368V	RPL3_uc003axh.2_Missense_Mutation_p.I319V|RPL3_uc003axj.2_Missense_Mutation_p.I216V|RPL3_uc010gxx.2_Intron|RPL3_uc003axg.2_Missense_Mutation_p.I316V|RPL3_uc003axk.1_Missense_Mutation_p.I216V	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	368					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					GTGGTGTCAATGAACTTAAGG	0.572			NA											3	11					0	0	0.004672	0	0
TAB1	10454	broad.mit.edu	37	22	39817853	39817853	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:39817853C>T	uc003axt.2	+	8	847	c.798C>T	c.(796-798)ATC>ATT	p.I266I	TAB1_uc003axr.2_Silent_p.I342I|TAB1_uc011aok.1_Silent_p.I100I|TAB1_uc003axu.1_Silent_p.I266I	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	266	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CCAAACCAATCATCGCAGAGC	0.587			NA											13	62					0	0	0.00245	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139765	40139765	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:40139765C>T	uc003ayg.2	-	7	1994	c.1743G>A	c.(1741-1743)ATG>ATA	p.M581I		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	581										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GACTCATGCTCATCAAGATGT	0.403			NA											8	47					0	0	0.00308	0	0
EP300	2033	broad.mit.edu	37	22	41489047	41489047	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:41489047C>G	uc003azl.3	+	1	434	c.39C>G	c.(37-39)GCC>GCG	p.A13A		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	13	Interaction with ALX1.|Nuclear localization signal (Potential).				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CGCCTTCAGCCAAGCGGCCTA	0.547			NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybsyndrome				6	101					0	0	0.001984	0	0
MPPED1	758	broad.mit.edu	37	22	43821208	43821208	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:43821208G>T	uc011apv.1	+	2	440	c.217G>T	c.(217-219)GTG>TTG	p.V73L	MPPED1_uc011apw.1_Intron|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.V73L|MPPED1_uc011apz.1_Missense_Mutation_p.V106L	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	73							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				GCCACCGCATGTGCAGATGTA	0.657			NA											9	15					0.00448238	0.00518058	0.004482	1	0
C22orf9	23313	broad.mit.edu	37	22	45595905	45595905	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:45595905G>T	uc003bfx.1	-	8	930	c.864C>A	c.(862-864)TTC>TTA	p.F288L	C22orf9_uc010gzw.1_Missense_Mutation_p.F140L|C22orf9_uc003bfv.1_Missense_Mutation_p.F297L|C22orf9_uc003bfw.1_Missense_Mutation_p.F293L|C22orf9_uc010gzx.2_Missense_Mutation_p.F270L	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	288							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GGGGTGTGCTGAAGGAGGTCA	0.612			NA											7	25					0.000442599	0.000529778	0.006214	1	0
FBLN1	2192	broad.mit.edu	37	22	45923784	45923784	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:45923784G>C	uc003bgj.1	+	4	526	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	FBLN1_uc003bgg.1_Missense_Mutation_p.E127Q|FBLN1_uc003bgh.2_Missense_Mutation_p.E127Q|FBLN1_uc010gzz.2_Missense_Mutation_p.E165Q|FBLN1_uc003bgi.1_Missense_Mutation_p.E127Q	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	127	Anaphylatoxin-like 3.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCAGAGCTGCGAGTACAGCCT	0.622			NA											16	48					0	0	0.004007	0	0
ZBED4	9889	broad.mit.edu	37	22	50280622	50280622	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr22:50280622G>A	uc003bix.2	+	2	3782	c.3312G>A	c.(3310-3312)TGG>TGA	p.W1104*		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	1104						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TCACCTACTGGAACCTGAAGA	0.567			NA											7	16					0	0	0.001984	0	0
GRM7	2917	broad.mit.edu	37	3	7340513	7340513	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:7340513G>T	uc003bqm.2	+	3	1152	c.878_splice	c.e3+1	p.K293_splice	GRM7_uc011ata.1_Splice_Site|GRM7_uc011atb.1_Splice_Site|GRM7_uc010hcf.2_Splice_Site|GRM7_uc011atc.1_Splice_Site|GRM7_uc010hcg.2_Splice_Site_p.K293_splice|GRM7_uc003bql.2_Splice_Site_p.K293_splice|GRM7_uc003bqn.1_Splice_Site	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a						negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	AGGATATAAAGTAAGAATAAC	0.413			NA											10	29					3.07112e-06	4.16617e-06	0.000978	1	0
SRGAP3	9901	broad.mit.edu	37	3	9055201	9055201	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:9055201G>T	uc003brf.1	-	17	2614	c.1938C>A	c.(1936-1938)GAC>GAA	p.D646E	SRGAP3_uc003brg.1_Missense_Mutation_p.D622E	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	646	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCATGTTCTCGTCGCTATACT	0.542			NA	T	RAF1	pilocytic astrocytoma								11	32					0.000978159	0.00115742	0.000978	1	0
SRGAP3	9901	broad.mit.edu	37	3	9074378	9074378	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:9074378A>T	uc003brf.1	-	12	2171	c.1495T>A	c.(1495-1497)TAT>AAT	p.Y499N	SRGAP3_uc003brg.1_Intron|SRGAP3_uc003bri.1_RNA	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	499	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TTATGGCTATACACTGAGAGA	0.493			NA	T	RAF1	pilocytic astrocytoma								16	60					0	0	0.00499	0	0
SETD5	55209	broad.mit.edu	37	3	9515147	9515147	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:9515147G>T	uc003brt.2	+	20	3858	c.3423G>T	c.(3421-3423)GAG>GAT	p.E1141D	SETD5_uc003bru.2_Missense_Mutation_p.E1043D|SETD5_uc003brv.2_Missense_Mutation_p.E1030D|SETD5_uc010hck.2_Missense_Mutation_p.E623D|SETD5_uc003brx.2_Missense_Mutation_p.E810D	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	1141	Ser-rich.									ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CCCATTTGGAGGCGGTAAGCC	0.478			NA											5	12					3.59834e-05	4.57629e-05	0.001168	1	0
C3orf24	115795	broad.mit.edu	37	3	10146187	10146187	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:10146187G>A	uc003buz.2	-	2	497	c.272C>T	c.(271-273)CCC>CTC	p.P91L	C3orf24_uc003bva.1_Missense_Mutation_p.P91L	NM_173472	NP_775743	Q96PS1	CC024_HUMAN	hypothetical protein LOC115795	91											0				OV - Ovarian serous cystadenocarcinoma(96;0.196)		GATGGGCTGGGGCTTCCTGAC	0.532			NA											19	53					0	0	0.001216	0	0
SLC6A1	6529	broad.mit.edu	37	3	11072886	11072886	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:11072886C>G	uc010hdq.2	+	13	1758	c.1347C>G	c.(1345-1347)CTC>CTG	p.L449L		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	449					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCTTCAAACTCTTTGACTACT	0.498			NA											6	159					0	0	0.001984	0	0
CAND2	23066	broad.mit.edu	37	3	12845083	12845083	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:12845083G>T	uc003bxk.2	+	2	214	c.165G>T	c.(163-165)CGG>CGT	p.R55R	CAND2_uc003bxj.2_Silent_p.R55R	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	55	HEAT 2.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						TGCTGCTCCGGCTCCTGGAGG	0.617	GBM(43;676 868 1633 6395 37496)		NA											12	14					0.00010058	0.000124382	0.001368	1	0
KCNH8	131096	broad.mit.edu	37	3	19295220	19295220	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:19295220G>T	uc003cbk.1	+	2	346	c.151G>T	c.(151-153)GAG>TAG	p.E51*	KCNH8_uc011awe.1_Nonsense_Mutation_p.E51*|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	51	Cytoplasmic (Potential).|PAS.					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TGGCTTCTGCGAGCTTGCTGG	0.448	NSCLC(124;1625 1765 8018 24930 42026)		NA											46	103					6.08268e-21	1.1754e-20	0.00361	1	0
SUSD5	26032	broad.mit.edu	37	3	33195367	33195367	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:33195367T>A	uc003cfo.1	-	5	1175	c.757A>T	c.(757-759)ATT>TTT	p.I253F		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	253	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						CCCACAGAAATGGAGACCAGA	0.562			NA											11	33					0	0	0.000978	0	0
GOLGA4	2803	broad.mit.edu	37	3	37360566	37360566	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:37360566G>C	uc003cgv.2	+	12	1730	c.1426G>C	c.(1426-1428)GAA>CAA	p.E476Q	GOLGA4_uc010hgr.1_Intron|GOLGA4_uc003cgw.2_Missense_Mutation_p.E498Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.E357Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	476	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ATCCTCAGAAGAACAAATTGC	0.363			NA											4	95					0	0	0.000248	0	0
SCN10A	6336	broad.mit.edu	37	3	38797302	38797302	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:38797302C>G	uc003ciq.2	-	10	1438	c.1438G>C	c.(1438-1440)GAT>CAT	p.D480H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	480					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGTAAGGATCAGAGCGGGGT	0.264			NA											6	154					0	0	0.004482	0	0
MYRIP	25924	broad.mit.edu	37	3	40211460	40211460	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:40211460G>T	uc003cka.2	+	8	884	c.749G>T	c.(748-750)AGC>ATC	p.S250I	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.S250I|MYRIP_uc010hhw.2_Missense_Mutation_p.S161I|MYRIP_uc011ayz.1_Missense_Mutation_p.S63I	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	250	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AAACAGAAGAGCAAAAGTGAG	0.532			NA											15	19					2.31682e-05	2.98321e-05	0.003163	1	0
ZNF502	91392	broad.mit.edu	37	3	44763714	44763714	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:44763714G>T	uc011baa.1	+	4	1660	c.1405G>T	c.(1405-1407)GGG>TGG	p.G469W	ZNF502_uc003cns.2_Missense_Mutation_p.G469W|ZNF502_uc011bab.1_Missense_Mutation_p.G469W|ZNF502_uc003cnt.2_Missense_Mutation_p.G469W	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	469	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TAAAGAATGTGGGAAAGCCTT	0.403			NA											15	20					1.49906e-05	1.9584e-05	0.00245	1	0
LIMD1	8994	broad.mit.edu	37	3	45714995	45714995	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:45714995G>T	uc003coq.2	+	6	1871	c.1822G>T	c.(1822-1824)GAG>TAG	p.E608*		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	608	LIM zinc-binding 3.|Necessary for nuclear localization.				cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		CCTTCCACCTGAGGTAAGATG	0.512			NA											23	69					0.00278032	0.00324411	0.00278	1	0
NISCH	11188	broad.mit.edu	37	3	52524743	52524743	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:52524743C>A	uc011beg.1	+	20	3708	c.3636C>A	c.(3634-3636)ACC>ACA	p.T1212T	NISCH_uc003ded.3_Silent_p.T1212T|NISCH_uc003dee.3_Silent_p.T701T|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1212					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		AGAAAAACACCGACTACAACA	0.532			NA											23	76					1.55469e-16	2.86413e-16	0.00333	1	0
PBRM1	55193	broad.mit.edu	37	3	52649423	52649423	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:52649423T>C	uc003des.2	-	15	1880	c.1868A>G	c.(1867-1869)AAA>AGA	p.K623R	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.K623R|PBRM1_uc003der.2_Missense_Mutation_p.K591R|PBRM1_uc003det.2_Missense_Mutation_p.K638R|PBRM1_uc003deu.2_Missense_Mutation_p.K638R|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.K623R|PBRM1_uc010hmk.1_Missense_Mutation_p.K623R|PBRM1_uc003dey.2_Missense_Mutation_p.K623R|PBRM1_uc003dez.1_Missense_Mutation_p.K623R|PBRM1_uc003dfb.1_Missense_Mutation_p.K536R|PBRM1_uc003dfc.2_5'UTR	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	623					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GCCCAGCTCTTTCCTTTTCTC	0.373			NA	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								16	46					0	0	0.006122	0	0
PTPRG	5793	broad.mit.edu	37	3	62118337	62118337	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:62118337A>G	uc003dlb.2	+	6	1396	c.677A>G	c.(676-678)CAT>CGT	p.H226R	PTPRG_uc003dlc.2_Missense_Mutation_p.H226R	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	226	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GGTGTCGTACATCATGGTAAG	0.438			NA											35	53					0	0	0.006999	0	0
MAGI1	9223	broad.mit.edu	37	3	65456114	65456115	+	Missense_Mutation	DNP	AA	AA	TG			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:65456114_65456115AA>TG	uc003dmn.2	-	5	1328_1329	c.802_803TT>CA	c.(802-804)TTA>CAA	p.L268Q	MAGI1_uc003dmm.2_Missense_Mutation_p.L268Q|MAGI1_uc003dmo.2_Missense_Mutation_p.L268Q|MAGI1_uc003dmp.2_Missense_Mutation_p.L268Q|MAGI1_uc010hny.2_Missense_Mutation_p.L153Q|MAGI1_uc003dmr.2_Missense_Mutation_p.L269Q	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	268	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CACAGGTGGTAATGCTGTTTCT	0.446			NA											20	51					0	0	0.004672	0	0
PROS1	5627	broad.mit.edu	37	3	93603635	93603635	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:93603635C>A	uc003drb.3	-	12	1770	c.1429G>T	c.(1429-1431)GTT>TTT	p.V477F	PROS1_uc010hoo.2_Missense_Mutation_p.V346F|PROS1_uc003dqz.3_Missense_Mutation_p.V346F	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	477					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TCCACAGTAACCAGGCAATGC	0.363			NA											16	41					1.5739e-10	2.54668e-10	0.004007	1	0
EPHA6	285220	broad.mit.edu	37	3	97454805	97454805	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:97454805G>T	uc010how.1	+	16	3014	c.2971G>T	c.(2971-2973)GCT>TCT	p.A991S	EPHA6_uc003drt.2_Missense_Mutation_p.A383S|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	896	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CAGACTTCCAGCTCCCATGGG	0.418			NA											8	37					3.86212e-05	4.87942e-05	0.008291	1	0
OR5K3	403277	broad.mit.edu	37	3	98109831	98109831	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:98109831G>C	uc011bgw.1	+	1	322	c.322G>C	c.(322-324)GAA>CAA	p.E108Q		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGTCTTGCTGAAACTACAGA	0.438			NA											44	154					0	0	0.002852	0	0
GPR128	84873	broad.mit.edu	37	3	100356151	100356151	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:100356151G>A	uc003duc.2	+	6	871	c.603G>A	c.(601-603)AAG>AAA	p.K201K	GPR128_uc011bhc.1_5'UTR	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	201	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GGCAGGCAAAGAAAGTTGCCA	0.348	Pancreas(87;185 1975 7223 18722)		NA											3	37					0	0	0.000602	0	0
GPR128	84873	broad.mit.edu	37	3	100374023	100374023	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:100374023G>T	uc003duc.2	+	12	1992	c.1724G>T	c.(1723-1725)TGG>TTG	p.W575L	GPR128_uc011bhc.1_Missense_Mutation_p.W276L|GPR128_uc003dud.2_Missense_Mutation_p.W98L	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	575	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TTAATTGGATGGGGTAAGTGT	0.318	Pancreas(87;185 1975 7223 18722)		NA											15	61					3.35478e-16	6.13823e-16	0.003163	1	0
TRAT1	50852	broad.mit.edu	37	3	108568088	108568088	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:108568088C>A	uc003dxi.1	+	5	434	c.290C>A	c.(289-291)ACC>AAC	p.T97N	TRAT1_uc010hpx.1_Missense_Mutation_p.T60N	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	97	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CAGGAAGCCACCCCATCTGCA	0.373			NA											14	48					0.000308642	0.000372422	0.003163	1	0
MORC1	27136	broad.mit.edu	37	3	108723721	108723721	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:108723721A>T	uc003dxl.2	-	20	2115	c.2028T>A	c.(2026-2028)GCT>GCA	p.A676A	MORC1_uc011bhn.1_Silent_p.A655A	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	676					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TGGTAATATTAGCAATCTGAC	0.353			NA											51	149					0	0	0.00361	0	0
CCDC80	151887	broad.mit.edu	37	3	112358068	112358068	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:112358068C>A	uc003dzf.2	-	2	903	c.685G>T	c.(685-687)GAG>TAG	p.E229*	CCDC80_uc011bhv.1_Nonsense_Mutation_p.E229*|CCDC80_uc003dzg.2_Nonsense_Mutation_p.E229*|CCDC80_uc003dzh.1_Nonsense_Mutation_p.E229*	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	229										ovary(2)	2						TTGCCCTTCTCCAGCTTCAGG	0.577			NA											38	107					3.93418e-24	7.69084e-24	0.004289	1	0
HCLS1	3059	broad.mit.edu	37	3	121376180	121376180	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:121376180T>C	uc003eeh.3	-	3	229	c.104A>G	c.(103-105)GAG>GGG	p.E35G	HCLS1_uc011bjj.1_Missense_Mutation_p.E35G|HCLS1_uc011bjk.1_RNA|HCLS1_uc011bjl.1_Missense_Mutation_p.E35G	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	35	Involved in HAX-1 binding.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		CCATCGTTGCTCCTTTTCAGA	0.517			NA											36	135					0	0	0.004878	0	0
GOLGB1	2804	broad.mit.edu	37	3	121433816	121433816	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:121433816G>C	uc003eei.3	-	10	1407	c.1281C>G	c.(1279-1281)CTC>CTG	p.L427L	GOLGB1_uc010hrc.2_Silent_p.L432L|GOLGB1_uc003eej.3_Silent_p.L393L|GOLGB1_uc011bjm.1_Silent_p.L313L|GOLGB1_uc010hrd.1_Silent_p.L391L	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	427	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ATTTTTGCTGGAGCTGATCTA	0.318			NA											12	72					0	0	0.000978	0	0
DIRC2	84925	broad.mit.edu	37	3	122591347	122591347	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:122591347C>G	uc003efw.3	+	8	1363	c.1224C>G	c.(1222-1224)GTC>GTG	p.V408V	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Silent_p.V246V	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	408					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TGGAAACTGTCTACCCAGTTC	0.348			NA											33	136					0	0	0.002445	0	0
PDIA5	10954	broad.mit.edu	37	3	122873846	122873846	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:122873846G>T	uc003egc.1	+	15	1358	c.1302G>T	c.(1300-1302)CCG>CCT	p.P434P	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	434	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		AGGTCATTCCGCACTTTACTG	0.532			NA											31	83					1.74807e-11	2.90552e-11	0.002096	1	0
COL29A1	256076	broad.mit.edu	37	3	130095164	130095164	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:130095164C>A	uc010htj.1	+	3	646	c.152C>A	c.(151-153)ACG>AAG	p.T51K	COL29A1_uc010hti.1_RNA	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	51	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen					0						TTCGTGAAAACGTTCATCAAC	0.478			NA											21	67					1.00905e-13	1.76682e-13	0.001216	1	0
C3orf36	80111	broad.mit.edu	37	3	133647523	133647523	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:133647523C>T	uc003epz.1	-	1	1134	c.125G>A	c.(124-126)GGA>GAA	p.G42E		NM_025041	NP_079317	Q3SXR2	CC036_HUMAN	hypothetical protein LOC80111	42										ovary(1)	1						GGCCATTCCTCCAGGCCCTGA	0.622			NA											15	38					0	0	0.003163	0	0
EPHB1	2047	broad.mit.edu	37	3	134851709	134851709	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:134851709G>T	uc003eqt.2	+	5	1335	c.1115G>T	c.(1114-1116)CGC>CTC	p.R372L	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	372	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AGCTGCTCCCGCTGTGACGAC	0.617			NA											7	22					0.00448238	0.00518058	0.004482	1	0
EPHB1	2047	broad.mit.edu	37	3	134885845	134885845	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:134885845C>A	uc003eqt.2	+	9	1976	c.1756C>A	c.(1756-1758)CGA>AGA	p.R586R	EPHB1_uc003equ.2_Silent_p.R147R	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	586	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CAGCACAGGCCGAGGTAAGTA	0.547			NA											22	179					4.16121e-05	5.25236e-05	0.00278	1	0
SLC25A36	55186	broad.mit.edu	37	3	140689777	140689777	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:140689777G>C	uc003etr.2	+	5	629	c.394G>C	c.(394-396)GCA>CCA	p.A132P	SLC25A36_uc003ets.2_Missense_Mutation_p.A132P|SLC25A36_uc003etq.2_5'UTR|SLC25A36_uc011bmz.1_Missense_Mutation_p.A106P	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	132	Solcar 2.				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						AGGTTTTACTGCAATCACAGC	0.294			NA											11	37					0	0	0.001368	0	0
ACPL2	92370	broad.mit.edu	37	3	140997196	140997196	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:140997196C>T	uc003etu.2	+	5	391	c.92C>T	c.(91-93)CCG>CTG	p.P31L	ACPL2_uc003etv.2_Missense_Mutation_p.P31L|ACPL2_uc011bna.1_5'UTR|ACPL2_uc011bnb.1_Missense_Mutation_p.P14L	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	31						extracellular region	acid phosphatase activity			skin(1)	1						CACCTGATCCCGGTGTCGACT	0.567			NA											10	36					0	0	0.006214	0	0
ZBTB38	253461	broad.mit.edu	37	3	141164114	141164114	+	Missense_Mutation	SNP	G	G	T	rs75545796	by1000genomes	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:141164114G>T	uc003etw.2	+	8	3866	c.2884G>T	c.(2884-2886)GTG>TTG	p.V962L	ZBTB38_uc010hun.2_Missense_Mutation_p.V959L|ZBTB38_uc010huo.2_Missense_Mutation_p.V962L|ZBTB38_uc003ety.2_Missense_Mutation_p.V962L|ZBTB38_uc010hup.2_Missense_Mutation_p.V963L	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	962					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GGATTGCGCCGTGGGGAAGGC	0.498			NA											8	27					3.09899e-07	4.40883e-07	0.004482	1	0
XRN1	54464	broad.mit.edu	37	3	142139947	142139947	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:142139947C>G	uc003eus.2	-	10	1151	c.1084G>C	c.(1084-1086)GAA>CAA	p.E362Q	XRN1_uc003eut.2_Missense_Mutation_p.E362Q|XRN1_uc003euu.2_Missense_Mutation_p.E362Q|XRN1_uc003euv.1_Missense_Mutation_p.E223Q|XRN1_uc003euw.2_Missense_Mutation_p.E362Q|XRN1_uc011bnh.1_Missense_Mutation_p.E152Q	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	362					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ACTTTGCTTTCAAACCATTTT	0.338			NA											5	131					0	0	0.001168	0	0
CHST2	9435	broad.mit.edu	37	3	142841199	142841199	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:142841199C>A	uc003evm.2	+	2	2430	c.1541C>A	c.(1540-1542)CCT>CAT	p.P514H		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	514	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GTCAACAGCCCTGAGGAGGTC	0.572			NA											10	32					0.000442599	0.000529778	0.006214	1	0
SLC9A9	285195	broad.mit.edu	37	3	142985603	142985603	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:142985603C>A	uc003evn.2	-	16	2061	c.1879G>T	c.(1879-1881)GGC>TGC	p.G627C		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	627					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CCTCCCAGGCCGAGGTCTCCC	0.498			NA											23	82					9.95505e-16	1.79458e-15	0.002299	1	0
FAM194A	131831	broad.mit.edu	37	3	150384672	150384672	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:150384672G>T	uc003eyg.2	-	13	1687	c.1630C>A	c.(1630-1632)CGT>AGT	p.R544S	FAM194A_uc003eyh.2_Missense_Mutation_p.R398S	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	544										skin(2)|ovary(1)	3						CCAATATAACGGTTCAAAGCC	0.413			NA											23	64					5.35356e-11	8.74675e-11	0.00278	1	0
P2RY14	9934	broad.mit.edu	37	3	150931206	150931206	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:150931206T>A	uc003eyr.1	-	3	1377	c.899A>T	c.(898-900)CAG>CTG	p.Q300L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Missense_Mutation_p.Q300L	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	300	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTAAACGGCTGGCATAGAAA	0.358			NA											27	81					0	0	0.007291	0	0
SHOX2	6474	broad.mit.edu	37	3	157823666	157823666	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:157823666C>T	uc003fbr.2	-	1	287	c.148G>A	c.(148-150)GAC>AAC	p.D50N	SHOX2_uc003fbs.2_Missense_Mutation_p.D50N|SHOX2_uc010hvw.2_Missense_Mutation_p.D50N	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	50					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CTGCTGCGGTCGTCGCGGCCC	0.453			NA											3	7					0	0	0.004672	0	0
SI	6476	broad.mit.edu	37	3	164724727	164724727	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:164724727G>T	uc003fei.2	-	37	4345	c.4283C>A	c.(4282-4284)ACT>AAT	p.T1428N		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1428	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAATCCATCAGTTCTTTTTGT	0.333			NA								HNSCC(35;0.089)			11	18					5.50884e-06	7.37624e-06	0.001368	1	0
SI	6476	broad.mit.edu	37	3	164737505	164737505	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:164737505G>T	uc003fei.2	-	28	3370	c.3308C>A	c.(3307-3309)TCG>TAG	p.S1103*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1103	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAGGCGAGTCGATATTTGAAT	0.378			NA								HNSCC(35;0.089)			9	73					0.00621372	0.00712032	0.006214	1	0
SI	6476	broad.mit.edu	37	3	164786549	164786549	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:164786549G>T	uc003fei.2	-	5	506	c.444C>A	c.(442-444)TTC>TTA	p.F148L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	148	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTTGAGTTGTGAAGAGAACAC	0.333			NA								HNSCC(35;0.089)			22	78					6.44725e-10	1.02469e-09	0.002299	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906813	164906813	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:164906813C>T	uc003fej.3	-	2	2250	c.1806G>A	c.(1804-1806)GTG>GTA	p.V602V	SLITRK3_uc003fek.2_Silent_p.V602V	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	602	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CAATAGTGCGCACATCACGGT	0.547			NA								HNSCC(40;0.11)			13	34					0	0	0.001368	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906974	164906974	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:164906974C>G	uc003fej.3	-	2	2089	c.1645G>C	c.(1645-1647)GAA>CAA	p.E549Q	SLITRK3_uc003fek.2_Missense_Mutation_p.E549Q	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	549	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TTCAAGTGTTCCAGGACACCA	0.532			NA								HNSCC(40;0.11)			13	41					0	0	0.00245	0	0
LRRC31	79782	broad.mit.edu	37	3	169587549	169587549	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:169587549G>C	uc003fgc.1	-	1	124	c.47C>G	c.(46-48)CCC>CGC	p.P16R	LRRC31_uc010hwp.1_Missense_Mutation_p.P16R	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	16										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TGAAGTCTGGGGCTTAGTTTC	0.443			NA											9	69					0	0	0.006214	0	0
SLC7A14	57709	broad.mit.edu	37	3	170216537	170216537	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:170216537C>A	uc003fgz.2	-	4	994	c.678G>T	c.(676-678)GTG>GTT	p.V226V	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	226	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TCATGATGAACACCCATACTG	0.507			NA											17	70					3.41278e-10	5.4499e-10	0.00499	1	0
FNDC3B	64778	broad.mit.edu	37	3	171830326	171830326	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:171830326G>T	uc003fhy.2	+	2	229	c.57G>T	c.(55-57)CTG>CTT	p.L19L	FNDC3B_uc003fhz.3_Silent_p.L19L|FNDC3B_uc003fhx.2_RNA	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	19						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CACCATTGCTGAACGGAGAGG	0.498			NA											20	73					8.10497e-08	1.18444e-07	0.001523	1	0
FNDC3B	64778	broad.mit.edu	37	3	171965348	171965348	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:171965348G>T	uc003fhy.2	+	5	462	c.290G>T	c.(289-291)CGC>CTC	p.R97L	FNDC3B_uc003fhz.3_Missense_Mutation_p.R97L|FNDC3B_uc003fia.2_Missense_Mutation_p.R28L	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	97						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACTGGAGTCCGCCGGGTGGTG	0.458			NA											32	120					5.6714e-07	7.96725e-07	0.002096	1	0
ECT2	1894	broad.mit.edu	37	3	172474909	172474909	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:172474909G>C	uc003fii.2	+	4	485	c.347G>C	c.(346-348)AGA>ACA	p.R116T	ECT2_uc010hwv.1_Missense_Mutation_p.R147T|ECT2_uc003fih.2_Missense_Mutation_p.R115T|ECT2_uc003fij.1_Missense_Mutation_p.R116T|ECT2_uc003fik.1_Missense_Mutation_p.R116T|ECT2_uc003fil.1_Missense_Mutation_p.R147T	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	116					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			GCTGATTGTAGAGTTATTGGA	0.308			NA											6	96					0	0	0.001984	0	0
PEX5L	51555	broad.mit.edu	37	3	179605484	179605484	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:179605484C>A	uc003fki.1	-	4	417	c.287G>T	c.(286-288)AGG>ATG	p.R96M	PEX5L_uc011bqd.1_Missense_Mutation_p.R53M|PEX5L_uc011bqe.1_Translation_Start_Site|PEX5L_uc011bqf.1_Missense_Mutation_p.R53M|PEX5L_uc003fkj.1_Missense_Mutation_p.R61M|PEX5L_uc010hxd.1_Missense_Mutation_p.R94M|PEX5L_uc011bqg.1_Missense_Mutation_p.R72M|PEX5L_uc011bqh.1_Missense_Mutation_p.R37M	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	96					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TGTTACTGGCCTTGCTATTGC	0.388			NA											36	158					5.43694e-19	1.03425e-18	0.005524	1	0
ECE2	9718	broad.mit.edu	37	3	184001646	184001646	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:184001646A>T	uc003fni.3	+	8	1282	c.1244A>T	c.(1243-1245)GAG>GTG	p.E415V	ECE2_uc011brh.1_Missense_Mutation_p.E268V|ECE2_uc003fnl.3_Missense_Mutation_p.E343V|ECE2_uc003fnm.3_Missense_Mutation_p.E297V|ECE2_uc003fnk.3_Missense_Mutation_p.E268V|ECE2_uc011bri.1_Missense_Mutation_p.E330V|ECE2_uc010hxv.2_Missense_Mutation_p.E59V	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	415	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCCACGAGGGAGCAGATGCAG	0.607			NA											7	44					0	0	0.001984	0	0
LIPH	200879	broad.mit.edu	37	3	185252583	185252583	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:185252583C>A	uc003fpm.2	-	2	497	c.387G>T	c.(385-387)ATG>ATT	p.M129I	LIPH_uc010hyh.2_Missense_Mutation_p.M129I	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	129					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CCTTCAAGACCATGGCTACTT	0.393			NA											20	41					2.94398e-08	4.37364e-08	0.007413	1	0
SENP2	59343	broad.mit.edu	37	3	185307917	185307917	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:185307917A>G	uc003fpn.2	+	2	288	c.117A>G	c.(115-117)ACA>ACG	p.T39T	SENP2_uc011brv.1_Silent_p.T29T|SENP2_uc011brw.1_5'UTR	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	39				T -> TA (in Ref. 1; AAG15309).	mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TGTTTTCTACAGTGGACACTG	0.254			NA											13	26					0	0	0.00245	0	0
AHSG	197	broad.mit.edu	37	3	186335114	186335114	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:186335114A>T	uc003fqk.3	+	4	629	c.548A>T	c.(547-549)GAG>GTG	p.E183V	AHSG_uc003fqj.2_Missense_Mutation_p.E183V|AHSG_uc003fql.3_Missense_Mutation_p.E184V|AHSG_uc003fqm.3_Missense_Mutation_p.E182V|AHSG_uc010hyp.2_Missense_Mutation_p.E146V	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	183	Cystatin fetuin-A-type 2.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TTTCAGCTGGAGGAAATTTCC	0.587			NA									OREG0015968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	77					0	0	0.002299	0	0
C3orf59	151963	broad.mit.edu	37	3	192517414	192517414	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:192517414C>A	uc011bsp.1	-	2	558	c.237G>T	c.(235-237)AAG>AAT	p.K79N		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	79											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		CCACTGGAAGCTTTTGGTCCA	0.448			NA											13	29					2.31682e-05	2.98321e-05	0.003163	1	0
ATP13A4	84239	broad.mit.edu	37	3	193201780	193201780	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:193201780G>C	uc003ftd.2	-	8	861	c.753C>G	c.(751-753)CTC>CTG	p.L251L	ATP13A4_uc003fte.1_Silent_p.L251L|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	251	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CGAGATGGTGGAGTTTTACAG	0.343			NA											13	127					0	0	0.00245	0	0
MUC4	4585	broad.mit.edu	37	3	195517450	195517450	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:195517450C>G	uc011bto.1	-	2	1461	c.1001G>C	c.(1000-1002)AGA>ACA	p.R334T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.R216T	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	339					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TTGAGATACTCTGGTGGTCTC	0.463			NA											4	208					0	0	0.000248	0	0
LRRC33	375387	broad.mit.edu	37	3	196386747	196386747	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr3:196386747A>T	uc003fwv.2	+	3	337	c.233A>T	c.(232-234)CAG>CTG	p.Q78L		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	78	Extracellular (Potential).|LRR 1.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CACTCCCTCCAGCCTTACCCT	0.677			NA											10	20					0	0	0.008291	0	0
PSAPL1	768239	broad.mit.edu	37	4	7435511	7435511	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:7435511A>T	uc011bwj.1	-	1	1190	c.1096T>A	c.(1096-1098)TGT>AGT	p.C366S	SORCS2_uc003gkb.3_Intron|SORCS2_uc011bwi.1_Intron	NM_001085382	NP_001078851	Q6NUJ1	SAPL1_HUMAN	prosaposin-like protein 1	366	Saposin B-type 3.				sphingolipid metabolic process	extracellular region|lysosome					0						CGGTTGCCACACAGACGGATG	0.607			NA											12	89					0	0	0.001368	0	0
PSAPL1	768239	broad.mit.edu	37	4	7435731	7435731	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:7435731C>G	uc011bwj.1	-	1	970	c.876G>C	c.(874-876)GTG>GTC	p.V292V	SORCS2_uc003gkb.3_Intron|SORCS2_uc011bwi.1_Intron	NM_001085382	NP_001078851	Q6NUJ1	SAPL1_HUMAN	prosaposin-like protein 1	292	Saposin B-type 3.				sphingolipid metabolic process	extracellular region|lysosome					0						CCTCACAGGTCACACCGGCCT	0.597			NA											6	23					0	0	0.001168	0	0
SLC2A9	56606	broad.mit.edu	37	4	9828093	9828093	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:9828093C>T	uc003gmc.2	-	12	1612	c.1551G>A	c.(1549-1551)AGG>AGA	p.R517R	SLC2A9_uc003gmd.2_Silent_p.R488R	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	517	Cytoplasmic (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						ATGCTTTGTTCCTTTTGGAAA	0.423			NA											31	129					0	0	0.002445	0	0
BOD1L	259282	broad.mit.edu	37	4	13604345	13604345	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:13604345C>A	uc003gmz.1	-	10	4296	c.4179G>T	c.(4177-4179)GTG>GTT	p.V1393V	BOD1L_uc010idr.1_Silent_p.V730V	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1393							DNA binding			ovary(5)|breast(1)	6						TTTCCACAATCACGCCCGTTA	0.398			NA											29	99					1.88708e-17	3.50533e-17	0.008361	1	0
SLIT2	9353	broad.mit.edu	37	4	20525666	20525666	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:20525666A>T	uc003gpr.1	+	14	1508	c.1304A>T	c.(1303-1305)GAC>GTC	p.D435V	SLIT2_uc003gps.1_Missense_Mutation_p.D435V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	435	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TTTATTTGTGACTGCCATCTC	0.483			NA											31	138					0	0	0.008361	0	0
SLIT2	9353	broad.mit.edu	37	4	20541151	20541151	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:20541151T>C	uc003gpr.1	+	19	2124	c.1920T>C	c.(1918-1920)AAT>AAC	p.N640N	SLIT2_uc003gps.1_Silent_p.N632N	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	640	LRR 16.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGTATGATAATCAAATTACTA	0.378			NA											9	42					0	0	0.004482	0	0
PCDH7	5099	broad.mit.edu	37	4	30724559	30724559	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:30724559C>G	uc003gsk.1	+	1	2523	c.1515C>G	c.(1513-1515)ATC>ATG	p.I505M	PCDH7_uc011bxw.1_Missense_Mutation_p.I458M|PCDH7_uc011bxx.1_Missense_Mutation_p.I505M	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	505	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						ACGTGGTCATCGTGGCGGTGG	0.602			NA											12	25					0	0	0.000978	0	0
WDR19	57728	broad.mit.edu	37	4	39255635	39255635	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:39255635T>C	uc003gtv.2	+	26	3140	c.2986T>C	c.(2986-2988)TAT>CAT	p.Y996H	WDR19_uc011byi.1_Missense_Mutation_p.Y836H|WDR19_uc003gtw.1_Missense_Mutation_p.Y593H	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	996					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AATGGAAATCTATGCAGATAT	0.358			NA											5	72					0	0	0.000602	0	0
SHISA3	152573	broad.mit.edu	37	4	42403163	42403163	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:42403163C>A	uc003gwp.2	+	2	630	c.412C>A	c.(412-414)CTC>ATC	p.L138I		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	138	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						CCGCTTCTCACTCCGCAGCTA	0.587			NA											28	234					5.60225e-13	9.65831e-13	0.001786	1	0
ATP8A1	10396	broad.mit.edu	37	4	42487601	42487601	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:42487601C>A	uc003gwr.2	-	25	2468	c.2236G>T	c.(2236-2238)GGG>TGG	p.G746W	ATP8A1_uc003gwq.2_Intron|ATP8A1_uc003gws.2_Missense_Mutation_p.G731W	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	746	Cytoplasmic (Potential).|ATP (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	AGGGTTTTCCCATCAATTATA	0.418			NA											11	38					6.40141e-05	8.03467e-05	0.000978	1	0
GABRG1	2565	broad.mit.edu	37	4	46053441	46053441	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:46053441C>A	uc003gxb.2	-	8	1283	c.1131G>T	c.(1129-1131)TCG>TCT	p.S377S		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	377	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTTAACATACCGAGGCTTTAT	0.313			NA											5	12					1.024e-07	1.49157e-07	0.000602	1	0
GABRB1	2560	broad.mit.edu	37	4	47427936	47427936	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:47427936C>A	uc003gxh.2	+	9	1700	c.1326C>A	c.(1324-1326)GAC>GAA	p.D442E	GABRB1_uc011bze.1_Missense_Mutation_p.D372E	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	442	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGATCCCCGACTTGACTGATG	0.557			NA											16	72					2.23348e-06	3.05455e-06	0.004007	1	0
LRRC66	339977	broad.mit.edu	37	4	52860965	52860965	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:52860965C>A	uc003gzi.2	-	4	2236	c.2223G>T	c.(2221-2223)GGG>GGT	p.G741G		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	741						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCTTGCTTGCCCCTGAGCTCT	0.488			NA											39	81					9.73076e-26	1.919e-25	0.006999	1	0
AASDH	132949	broad.mit.edu	37	4	57221417	57221417	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:57221417C>A	uc003hbn.2	-	6	1187	c.1034G>T	c.(1033-1035)GGT>GTT	p.G345V	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.G192V|AASDH_uc003hbo.2_Missense_Mutation_p.G245V|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Missense_Mutation_p.G345V|AASDH_uc003hbp.2_Missense_Mutation_p.G345V	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	345					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CTCTGTGATACCATAAACATT	0.393			NA											25	43					5.35356e-11	8.74675e-11	0.00278	1	0
AASDH	132949	broad.mit.edu	37	4	57221579	57221579	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:57221579G>A	uc003hbn.2	-	6	1025	c.872C>T	c.(871-873)ACA>ATA	p.T291I	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.T138I|AASDH_uc003hbo.2_Missense_Mutation_p.T191I|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Missense_Mutation_p.T291I|AASDH_uc003hbp.2_Missense_Mutation_p.T291I	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	291					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TCTAAGCAATGTTGGTGTTGC	0.343			NA											20	28					0	0	0.002299	0	0
LPHN3	23284	broad.mit.edu	37	4	62599255	62599255	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:62599255C>T	uc010ihh.2	+	5	1351	c.1178C>T	c.(1177-1179)CCT>CTT	p.P393L	LPHN3_uc003hcq.3_Missense_Mutation_p.P393L|LPHN3_uc010ihg.1_Missense_Mutation_p.P461L|LPHN3_uc003hcs.1_Missense_Mutation_p.P222L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	393	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GATTTTGGACCTCTGGATAGT	0.363			NA											6	19					0	0	0.001984	0	0
UBA6	55236	broad.mit.edu	37	4	68566807	68566807	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:68566807G>A	uc003hdg.3	-	1	83	c.31C>T	c.(31-33)CAG>TAG	p.Q11*	UBA6_uc003hdi.2_Nonsense_Mutation_p.Q11*|UBA6_uc003hdj.2_Nonsense_Mutation_p.Q11*|LOC550112_uc003hdl.3_5'Flank|LOC550112_uc003hdk.2_5'Flank	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	11					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TCTTCCCCCTGATGGGCGGCC	0.687			NA									OREG0016213	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44					0	0	0.006122	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69107514	69107514	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:69107514A>G	uc003hdw.3	-	2	153	c.17T>C	c.(16-18)ATA>ACA	p.I6T		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	6	Cytoplasmic (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TTGGGAAGATATGCCGTGCCT	0.383			NA											7	66					0	0	0.001984	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146396	70146396	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:70146396G>T	uc003hej.2	+	1	180	c.178G>T	c.(178-180)GCT>TCT	p.A60S	UGT2B28_uc010ihr.2_Missense_Mutation_p.A60S	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	60					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GGCATCTTCAGCTTCCATTCT	0.403			NA											88	134					1.16018e-38	2.33953e-38	0.00361	1	0
AFM	173	broad.mit.edu	37	4	74367545	74367545	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:74367545A>T	uc003hhb.2	+	13	1719	c.1688A>T	c.(1687-1689)GAT>GTT	p.D563V		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	563	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GAACTCACAGATGAAGAGCTG	0.383			NA											11	14					0	0	0.000978	0	0
CCDC158	339965	broad.mit.edu	37	4	77288729	77288729	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:77288729A>G	uc003hkb.3	-	11	1701	c.1548T>C	c.(1546-1548)AAT>AAC	p.N516N		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	516	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TGATCTCTGCATTGGTAGCCT	0.478			NA											5	69					0	0	0.000602	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691881	77691881	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:77691881G>T	uc011cbx.1	+	10	6405	c.5452G>T	c.(5452-5454)GTG>TTG	p.V1818L	SHROOM3_uc003hkg.2_Missense_Mutation_p.V1596L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1818	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGGAGAAGAGGTGGAGGCTCT	0.552			NA											30	83					1.88708e-17	3.50533e-17	0.008361	1	0
HPSE	10855	broad.mit.edu	37	4	84227453	84227453	+	Missense_Mutation	SNP	C	C	A	rs138882001	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:84227453C>A	uc003hoj.3	-	9	1208	c.1109G>T	c.(1108-1110)GGC>GTC	p.G370V	HPSE_uc010ika.2_Missense_Mutation_p.G312V|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_Intron|HPSE_uc011ccs.1_Missense_Mutation_p.G113V|HPSE_uc011cct.1_Intron|HPSE_uc003hok.3_Missense_Mutation_p.G370V	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	370					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GGCTGACAGGCCCAATTTATC	0.423			NA											15	52					2.23348e-06	3.05455e-06	0.004007	1	0
WDFY3	23001	broad.mit.edu	37	4	85731345	85731345	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:85731345T>C	uc003hpd.2	-	14	2448	c.2040A>G	c.(2038-2040)CAA>CAG	p.Q680Q	WDFY3_uc003hpf.2_Silent_p.Q680Q	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	680						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTTCAAACACTTGATTCTGGT	0.438			NA											4	98					0	0	0.000602	0	0
FAM190A	401145	broad.mit.edu	37	4	91229571	91229571	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:91229571C>T	uc003hsv.3	+	2	476	c.136C>T	c.(136-138)CCT>TCT	p.P46S	FAM190A_uc003hsu.3_Missense_Mutation_p.P46S|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.P46S	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	46	Ser-rich.									large_intestine(1)|ovary(1)	2						CAGTTCCTCTCCTTCCAGCAC	0.458			NA											5	56					0	0	0.000602	0	0
DKK2	27123	broad.mit.edu	37	4	107845822	107845822	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:107845822G>T	uc003hyi.2	-	3	1114	c.409C>A	c.(409-411)CCT>ACT	p.P137T	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Missense_Mutation_p.P137T	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	137					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GGGATGTGAGGGGTTAAGATG	0.433			NA											5	93					8.12818e-05	0.000101263	0.001984	1	0
SEC24B	10427	broad.mit.edu	37	4	110384497	110384497	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:110384497G>T	uc003hzk.2	+	2	629	c.574G>T	c.(574-576)GCG>TCG	p.A192S	SEC24B_uc003hzl.2_Missense_Mutation_p.A192S|SEC24B_uc011cfp.1_Missense_Mutation_p.A223S|SEC24B_uc011cfq.1_Missense_Mutation_p.A192S|SEC24B_uc011cfr.1_Missense_Mutation_p.A192S	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	192					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTCTAATGCCGCGTATCCTAG	0.453			NA											6	188					0.00116845	0.00137772	0.001168	1	0
SEC24B	10427	broad.mit.edu	37	4	110434907	110434907	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:110434907T>C	uc003hzk.2	+	10	1963	c.1908T>C	c.(1906-1908)CCT>CCC	p.P636P	SEC24B_uc003hzl.2_Silent_p.P601P|SEC24B_uc011cfp.1_Silent_p.P666P|SEC24B_uc011cfq.1_Silent_p.P635P|SEC24B_uc011cfr.1_Silent_p.P600P	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	636					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ATCTAGTTCCTGAAGAATTTA	0.333			NA											3	85					0	0	0.000248	0	0
C4orf31	79625	broad.mit.edu	37	4	121966809	121966809	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:121966809T>C	uc003idq.1	-	2	711	c.184A>G	c.(184-186)AAG>GAG	p.K62E		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	62											0						GAATACCTCTTAGGTGTATCT	0.358			NA											24	20					0	0	0.004656	0	0
PCDH10	57575	broad.mit.edu	37	4	134084345	134084345	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:134084345G>T	uc003iha.2	+	4	3837	c.3011G>T	c.(3010-3012)GGC>GTC	p.G1004V		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	1004	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCCACCTTTGGCAAAGAGAAG	0.517			NA											50	90					2.12129e-23	4.14082e-23	0.00361	1	0
LRBA	987	broad.mit.edu	37	4	151827516	151827516	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:151827516G>A	uc010ipj.2	-	12	2009	c.1535C>T	c.(1534-1536)TCA>TTA	p.S512L	LRBA_uc003ilu.3_Missense_Mutation_p.S512L|LRBA_uc010ipk.1_Missense_Mutation_p.S431L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	512						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CATAGCAATTGAGTTCTTCAA	0.308			NA											5	118					0	0	0.001984	0	0
DCHS2	54798	broad.mit.edu	37	4	155156222	155156222	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:155156222C>G	uc003inw.2	-	25	8217	c.8217G>C	c.(8215-8217)GAG>GAC	p.E2739D		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2739					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCAGGATGCTCTCTTTTGCCT	0.473			NA											6	33					0	0	0.001168	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156696161	156696161	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:156696161G>C	uc003ipc.2	+	3	286	c.119G>C	c.(118-120)AGA>ACA	p.R40T	GUCY1B3_uc011cio.1_Missense_Mutation_p.R40T|GUCY1B3_uc011cip.1_Missense_Mutation_p.R20T|GUCY1B3_uc003ipd.2_5'UTR|GUCY1B3_uc010iqf.2_Missense_Mutation_p.R40T|GUCY1B3_uc010iqg.2_5'UTR|GUCY1B3_uc011ciq.1_5'UTR	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	40					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		TTTCTTGTCAGAATAATATAT	0.358			NA											3	107					0	0	0.004672	0	0
ACCN5	51802	broad.mit.edu	37	4	156763423	156763423	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:156763423G>T	uc003ipe.1	-	6	992	c.945C>A	c.(943-945)TGC>TGA	p.C315*		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	315	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		ATTCCTTCAAGCAACCAGAAG	0.398			NA											21	43					3.62473e-10	5.78149e-10	0.001882	1	0
FNIP2	57600	broad.mit.edu	37	4	159753234	159753234	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:159753234G>C	uc003iqe.3	+	5	681	c.498G>C	c.(496-498)CTG>CTC	p.L166L	FNIP2_uc003iqd.2_Silent_p.L166L	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	166					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CTCCACAACTGATGATTAGTA	0.403			NA											6	36					0	0	0.001168	0	0
AADAT	51166	broad.mit.edu	37	4	171010812	171010812	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:171010812C>G	uc003isr.2	-	1	372	c.30G>C	c.(28-30)GCG>GCC	p.A10A	AADAT_uc003iss.2_Silent_p.A10A|AADAT_uc003ist.2_Silent_p.A10A	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II	10					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TGGCTGCGCTCGCTGCCGTGA	0.537			NA									OREG0016403	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	110					0	0	0.007835	0	0
KIAA1712	80817	broad.mit.edu	37	4	175223237	175223237	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:175223237C>G	uc003itr.2	+	4	551	c.137C>G	c.(136-138)TCT>TGT	p.S46C	KIAA1712_uc010iro.2_Missense_Mutation_p.S46C|KIAA1712_uc003its.2_RNA	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a	46						centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		ATCAGCTATTCTTTTACCTCA	0.328			NA											7	55					0	0	0.004482	0	0
NEIL3	55247	broad.mit.edu	37	4	178274629	178274629	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:178274629G>T	uc003iut.2	+	8	1324	c.1207G>T	c.(1207-1209)GAA>TAA	p.E403*	NEIL3_uc010irs.2_3'UTR	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	403					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CAGTACTTTGGAAAGAAAAAC	0.368			NA						BER_DNA_glycosylases					16	18					6.31663e-08	9.24099e-08	0.003163	1	0
TLR3	7098	broad.mit.edu	37	4	187003533	187003533	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:187003533C>G	uc003iyq.2	+	4	794	c.693C>G	c.(691-693)GTC>GTG	p.V231V	TLR3_uc011ckz.1_5'UTR|TLR3_uc003iyr.2_5'UTR	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	231	Lumenal (Potential).|LRR 8.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TGAACAATGTCCAGCTGGGTC	0.428			NA											17	98					0	0	0.006122	0	0
AHRR	57491	broad.mit.edu	37	5	376812	376812	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:376812A>G	uc003jav.2	+	4	388	c.344A>G	c.(343-345)GAG>GGG	p.E115G	AHRR_uc003jaw.2_Missense_Mutation_p.E111G|AHRR_uc010isy.2_Intron|AHRR_uc010isz.2_Missense_Mutation_p.E111G	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	115	PAS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCCGTGCTGGAGGGAAGGCTG	0.627			NA											16	7					0	0	0.004007	0	0
SLC6A19	340024	broad.mit.edu	37	5	1221362	1221362	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:1221362C>T	uc003jbw.3	+	11	1691	c.1635C>T	c.(1633-1635)ATC>ATT	p.I545I		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	545	Helical; Name=11; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCTGATCATCTTCCTCTTCT	0.567			NA											10	30					0	0	0.006214	0	0
ADCY2	108	broad.mit.edu	37	5	7396557	7396557	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:7396557C>A	uc003jdz.1	+	1	215	c.148C>A	c.(148-150)CTG>ATG	p.L50M		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	50	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CATCGTCTTCCTGCTGCTCAT	0.711			NA											46	26					1.38658e-30	2.75877e-30	0.00361	1	0
SEMA5A	9037	broad.mit.edu	37	5	9043077	9043077	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:9043077G>T	uc003jek.2	-	23	3869	c.3157C>A	c.(3157-3159)CCA>ACA	p.P1053T		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	1053	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTGAGATGTGGGTTGAAGTAT	0.328			NA											7	53					8.12818e-05	0.000101263	0.001984	1	0
SEMA5A	9037	broad.mit.edu	37	5	9063218	9063218	+	Splice_Site	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:9063218C>A	uc003jek.2	-	18	3012	c.2300_splice	c.e18-1	p.G767_splice		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor						cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCAGAAAGCCCTGCCAAGGAA	0.522			NA											5	22					0.000602214	0.000715729	0.000602	1	0
SEMA5A	9037	broad.mit.edu	37	5	9122858	9122858	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:9122858A>T	uc003jek.2	-	14	2403	c.1691T>A	c.(1690-1692)CTC>CAC	p.L564H		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	564	Extracellular (Potential).|TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGTTCGACAGAGGCAGGATCC	0.652			NA											7	127					0	0	0.00308	0	0
MARCH6	10299	broad.mit.edu	37	5	10417481	10417481	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:10417481C>T	uc003jet.1	+	22	2431	c.2248C>T	c.(2248-2250)CCC>TCC	p.P750S	MARCH6_uc011cmu.1_Missense_Mutation_p.P702S|MARCH6_uc003jeu.1_Missense_Mutation_p.P448S|MARCH6_uc011cmv.1_Missense_Mutation_p.P645S	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	750	Extracellular (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						CCTGAGGGTTCCCTTGGATCA	0.438			NA											6	195					0	0	0.00308	0	0
DNAH5	1767	broad.mit.edu	37	5	13766226	13766226	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:13766226C>T	uc003jfd.2	-	59	10002	c.9960G>A	c.(9958-9960)ATG>ATA	p.M3320I	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3320	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATGATCCGCATGATGAGGT	0.537			NA							Kartagener_syndrome				125	97					0	0	0.00361	0	0
DNAH5	1767	broad.mit.edu	37	5	13876872	13876872	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:13876872T>C	uc003jfd.2	-	22	3359	c.3317A>G	c.(3316-3318)TAT>TGT	p.Y1106C		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1106	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTCTTATAATAGTTCTTGGT	0.343			NA							Kartagener_syndrome				15	91					0	0	0.003163	0	0
MARCH11	441061	broad.mit.edu	37	5	16067773	16067773	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:16067773G>T	uc003jfo.2	-	4	1229	c.1016C>A	c.(1015-1017)TCC>TAC	p.S339Y	MARCH11_uc010itw.1_Missense_Mutation_p.S95Y	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	339						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						CCTACTTGTGGAAGACTCTCC	0.483			NA											15	70					1.05317e-09	1.65622e-09	0.00245	1	0
CDH12	1010	broad.mit.edu	37	5	22078722	22078722	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:22078722G>T	uc010iuc.2	-	2	522	c.64C>A	c.(64-66)CCA>ACA	p.P22T	CDH12_uc011cno.1_Missense_Mutation_p.P22T|CDH12_uc003jgk.2_Missense_Mutation_p.P22T	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	22					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GGTTGTAGTGGTGTTAGGAGA	0.458			NA								HNSCC(59;0.17)			61	241					2.40885e-21	4.68174e-21	0.00361	1	0
PRDM9	56979	broad.mit.edu	37	5	23509638	23509638	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:23509638G>T	uc003jgo.2	+	3	311	c.129G>T	c.(127-129)ATG>ATT	p.M43I		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	43	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGCAGAGATGGGAGACTGGG	0.433			NA								HNSCC(3;0.000094)			30	196					5.45727e-16	9.89084e-16	0.008361	1	0
TARS	6897	broad.mit.edu	37	5	33453497	33453497	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33453497G>C	uc003jhy.2	+	4	728	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	TARS_uc011cob.1_Missense_Mutation_p.E133Q|TARS_uc010iup.1_Missense_Mutation_p.E86Q|TARS_uc011coc.1_Missense_Mutation_p.E166Q|TARS_uc003jhz.2_Missense_Mutation_p.E41Q|TARS_uc011cod.1_Intron	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	145					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	TCTCAAGTTTGAGGATGAGGA	0.453			NA											12	125					0	0	0.001368	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33561252	33561253	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33561252_33561253CC>AA	uc003jia.1	-	20	4167_4168	c.4004_4005GG>TT	c.(4003-4005)TGG>TTT	p.W1335F	ADAMTS12_uc010iuq.1_Missense_Mutation_p.W1250F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1335	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCACCCTTCTCCAGTAGGCCCC	0.589			NA								HNSCC(64;0.19)			11	74					0	0	0.004672	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576225	33576225	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33576225G>T	uc003jia.1	-	19	4069	c.3906C>A	c.(3904-3906)GCC>GCA	p.A1302A	ADAMTS12_uc010iuq.1_Silent_p.A1217A	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1302	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTAATTGGAGGCATTTAGCA	0.473			NA								HNSCC(64;0.19)			46	252					6.61955e-31	1.319e-30	0.00361	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33683200	33683200	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33683200C>A	uc003jia.1	-	5	1001	c.838G>T	c.(838-840)GGG>TGG	p.G280W	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G280W	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	280	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGGAACAACCCAGTGACCTAG	0.373			NA								HNSCC(64;0.19)			12	36					1.49906e-05	1.9584e-05	0.00245	1	0
SLC45A2	51151	broad.mit.edu	37	5	33947441	33947441	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33947441C>A	uc003jid.2	-	6	1287	c.1195G>T	c.(1195-1197)GGT>TGT	p.G399C	SLC45A2_uc003jie.2_Missense_Mutation_p.G399C	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	399	Helical; Name=9; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AAGTAAAGACCCTTTAATCCA	0.453	Ovarian(31;380 859 8490 22203 49048)		NA											86	66					3.3814e-41	6.84951e-41	0.00361	1	0
TTC23L	153657	broad.mit.edu	37	5	34845617	34845617	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:34845617C>T	uc003jiu.2	+	3	197	c.94C>T	c.(94-96)CAC>TAC	p.H32Y		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	32							binding			central_nervous_system(1)	1						GATCCCAGCTCACCAGCAAAC	0.458			NA											5	91					0	0	0.000602	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049077	36049077	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:36049077A>T	uc003jjz.1	-	4	850	c.757T>A	c.(757-759)TTT>ATT	p.F253I	UGT3A2_uc011cos.1_Missense_Mutation_p.F219I|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	253	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCAAAGGCAAAGTCAGAGTTA	0.418			NA											22	106					0	0	0.00278	0	0
C5orf42	65250	broad.mit.edu	37	5	37169174	37169174	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:37169174C>A	uc011cpa.1	-	34	7183	c.6952G>T	c.(6952-6954)GAT>TAT	p.D2318Y	C5orf42_uc011coy.1_Missense_Mutation_p.D818Y|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D1393Y|C5orf42_uc003jkr.1_Missense_Mutation_p.D351Y	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2318										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACATATTGATCCAAGTTCACA	0.373			NA											26	172					2.79863e-10	4.48516e-10	0.004656	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41052593	41052593	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:41052593G>T	uc003jmj.3	-	12	1694	c.1204C>A	c.(1204-1206)CAG>AAG	p.Q402K	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	402							binding			ovary(6)|central_nervous_system(2)	8						GTTGCAAACTGGGAGAAGACA	0.388			NA											17	122					3.32936e-07	4.72157e-07	0.006122	1	0
HCN1	348980	broad.mit.edu	37	5	45262343	45262343	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:45262343G>T	uc003jok.2	-	8	2378	c.2353C>A	c.(2353-2355)CCA>ACA	p.P785T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	785	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCGGAGAGTGGCCTGACTTCC	0.627			NA											11	72					0.00010058	0.000124382	0.001368	1	0
GZMA	3001	broad.mit.edu	37	5	54403630	54403630	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:54403630G>T	uc003jpm.2	+	3	261	c.224G>T	c.(223-225)AGG>ATG	p.R75M		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	75	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				AGGAACAAAAGGTCCCAGGTC	0.388			NA											9	21					1.08611e-07	1.56675e-07	0.000978	1	0
VCAN	1462	broad.mit.edu	37	5	82816151	82816151	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:82816151C>G	uc003kii.3	+	7	2382	c.2026C>G	c.(2026-2028)CTA>GTA	p.L676V	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.L676V|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	676	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTATCCTTCTCTACAAACAGA	0.328			NA											21	35					0	0	0.001216	0	0
GPR98	84059	broad.mit.edu	37	5	89949444	89949444	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:89949444A>G	uc003kju.2	+	20	4149	c.4053A>G	c.(4051-4053)ACA>ACG	p.T1351T	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1351	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGAATAATACAATTGCCAACT	0.458			NA											4	14					0	0	0.000602	0	0
ERAP2	64167	broad.mit.edu	37	5	96232566	96232566	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:96232566A>T	uc003kmq.2	+	9	2212	c.1502A>T	c.(1501-1503)AAT>ATT	p.N501I	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.N501I|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.N450I|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	501	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		AGTCTGTCAAATGTAAGTCAT	0.323			NA											9	118					0	0	0.001368	0	0
FER	2241	broad.mit.edu	37	5	108134001	108134001	+	Nonsense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:108134001A>T	uc003kop.1	+	3	502	c.118A>T	c.(118-120)AAA>TAA	p.K40*	FER_uc011cve.1_Intron|FER_uc011cvf.1_RNA|FER_uc003koq.2_Nonsense_Mutation_p.K40*|FER_uc011cvg.1_5'UTR	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	40	Important for interaction with membranes containing phosphoinositides.|FCH.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		AAAAAGTGATAAAGAATATGC	0.343	Colon(146;1051 1799 9836 27344 47401)		NA											8	18					0	0	0.004482	0	0
TSLP	85480	broad.mit.edu	37	5	110407649	110407649	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:110407649C>A	uc003kpb.2	+	1	260	c.61C>A	c.(61-63)CAA>AAA	p.Q21K	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_5'Flank	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	21						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTTCATCTTACAACTTGTAGG	0.388			NA											32	45					1.30897e-18	2.47948e-18	0.001786	1	0
SEMA6A	57556	broad.mit.edu	37	5	115783231	115783231	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:115783231G>C	uc010jck.2	-	19	2880	c.2171C>G	c.(2170-2172)ACG>AGG	p.T724R	SEMA6A_uc003krx.3_Missense_Mutation_p.T741R|SEMA6A_uc011cwe.1_Missense_Mutation_p.T103R|SEMA6A_uc003krv.3_Missense_Mutation_p.T151R|SEMA6A_uc003krw.3_Missense_Mutation_p.T201R|SEMA6A_uc010jcj.2_Missense_Mutation_p.T268R	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	724	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CATGAGTGGCGTGAGGATGGC	0.632			NA											5	201					0	0	0.000602	0	0
DMXL1	1657	broad.mit.edu	37	5	118580152	118580152	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:118580152G>C	uc003ksd.2	+	42	8921	c.8740G>C	c.(8740-8742)GAC>CAC	p.D2914H	DMXL1_uc010jcl.1_Missense_Mutation_p.D2935H|DMXL1_uc010jcm.1_RNA|DMXL1_uc003kse.1_Missense_Mutation_p.D88H	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2914	WD 14.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ATATGTATTTGACCTTTGTCA	0.423			NA											8	37					0	0	0.00308	0	0
FTMT	94033	broad.mit.edu	37	5	121188138	121188138	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:121188138G>T	uc003kss.2	+	1	489	c.480G>T	c.(478-480)ATG>ATT	p.M160I		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	160	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TGCATGCCATGGAGTGTGCTC	0.557			NA											36	77					1.90571e-15	3.42161e-15	0.004289	1	0
FBN2	2201	broad.mit.edu	37	5	127611777	127611777	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:127611777G>A	uc003kuu.2	-	59	7986	c.7547C>T	c.(7546-7548)TCA>TTA	p.S2516L		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2516	EGF-like 42; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCTCGGACATGAACACTGATA	0.448			NA											7	50					0	0	0.001984	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037099	129037099	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:129037099G>C	uc003kvb.1	+	20	2955	c.2955G>C	c.(2953-2955)TGG>TGC	p.W985C	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	985	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGACAGAATGGACCCCTTGTT	0.388			NA											22	51					0	0	0.00333	0	0
IL9	3578	broad.mit.edu	37	5	135229727	135229727	+	Silent	SNP	T	T	C	rs144819897	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:135229727T>C	uc003lbb.1	-	4	308	c.297A>G	c.(295-297)CTA>CTG	p.L99L		NM_000590	NP_000581	P15248	IL9_HUMAN	interleukin 9 precursor	99					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGTTGTTCTTTAGTACTTCAA	0.398			NA											16	7					0	0	0.004007	0	0
KDM3B	51780	broad.mit.edu	37	5	137727287	137727287	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:137727287G>T	uc003lcy.1	+	8	2166	c.1966G>T	c.(1966-1968)GCA>TCA	p.A656S	KDM3B_uc010jew.1_Missense_Mutation_p.A312S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	656	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TGCATCTCAGGCATCAGGTAG	0.507			NA											28	33					4.22769e-11	6.95808e-11	0.00632	1	0
PCDHA3	56145	broad.mit.edu	37	5	140182981	140182981	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140182981G>T	uc003lhf.2	+	1	2199	c.2199G>T	c.(2197-2199)GGG>GGT	p.G733G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.G733G	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACTGTGGGCCGGGCAAGC	0.647			NA											40	65					9.73076e-26	1.919e-25	0.006999	1	0
PCDHA11	56138	broad.mit.edu	37	5	140249457	140249457	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140249457A>G	uc003lia.2	+	1	1627	c.769A>G	c.(769-771)AAA>GAA	p.K257E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.K257E	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	257	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATGCTGCTAAAGAAACTCT	0.428			NA											6	5					0	0	0.001168	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475034	140475034	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140475034G>T	uc003lil.2	+	1	798	c.660G>T	c.(658-660)GGG>GGT	p.G220G	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	220	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGATGGCGGGAGTCCACCCA	0.557			NA											7	22					0.00198382	0.00231877	0.001984	1	0
PCDHB17	54661	broad.mit.edu	37	5	140536781	140536781	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140536781A>T	uc003lis.2	+	1	1202	c.1202A>T	c.(1201-1203)TAC>TTC	p.Y401F		NR_001280				SubName: Full=Protocadherin-psi1;												0						GAAAATTTCTACACTTTGTTA	0.468			NA											7	22					0	0	0.001984	0	0
PCDHB9	56127	broad.mit.edu	37	5	140568367	140568367	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140568367G>T	uc003liw.1	+	3	1476	c.1476G>T	c.(1474-1476)CCG>CCT	p.P492P		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	492	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTGCTGCCGCCCCAGGACC	0.662			NA											75	112					3.54697e-40	7.16328e-40	0.00361	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604284	140604284	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:140604284C>A	uc003ljb.2	+	1	1207	c.1207C>A	c.(1207-1209)CTA>ATA	p.L403I	PCDHB14_uc011dal.1_Missense_Mutation_p.L250I	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	403	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTTCACTCTAGTTTCTGA	0.458	Ovarian(141;50 1831 27899 33809 37648)		NA											54	81					2.76378e-25	5.44247e-25	0.00361	1	0
SH3TC2	79628	broad.mit.edu	37	5	148392151	148392151	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:148392151A>T	uc003lpu.2	-	13	3352	c.3200T>A	c.(3199-3201)CTG>CAG	p.L1067Q	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.L711Q|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.L614Q|SH3TC2_uc010jgx.2_Missense_Mutation_p.L1060Q	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1067							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTACCTGCAGGCACAGCTC	0.597			NA											7	34					0	0	0.00308	0	0
CDX1	1044	broad.mit.edu	37	5	149563122	149563122	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:149563122C>A	uc003lrq.2	+	3	773	c.677C>A	c.(676-678)CCG>CAG	p.P226Q		NM_001804	NP_001795	P47902	CDX1_HUMAN	caudal type homeobox 1	226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACAGCCGCCGATGGCCCAC	0.637			NA											15	17					6.31663e-08	9.24099e-08	0.003163	1	0
NDST1	3340	broad.mit.edu	37	5	149907801	149907801	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:149907801G>T	uc003lsk.3	+	3	1451	c.949G>T	c.(949-951)GAC>TAC	p.D317Y	NDST1_uc011dcj.1_Missense_Mutation_p.D317Y|NDST1_uc003lsl.2_Missense_Mutation_p.D317Y	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	317	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATCCTGGTGGACATTGATGA	0.612			NA											14	37					2.31682e-05	2.98321e-05	0.003163	1	0
ANXA6	309	broad.mit.edu	37	5	150483222	150483222	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:150483222C>G	uc003ltl.1	-	25	2023	c.1871G>C	c.(1870-1872)AGG>ACG	p.R624T	ANXA6_uc011dcp.1_Missense_Mutation_p.R592T|ANXA6_uc003ltm.1_Missense_Mutation_p.R618T|ANXA6_uc003ltn.1_Missense_Mutation_p.R411T|ANXA6_uc003lto.1_Missense_Mutation_p.R211T	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	624	Annexin 8.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TACCATGATCCTGGTCAGAGT	0.532			NA											6	8					0	0	0.001984	0	0
ADAM19	8728	broad.mit.edu	37	5	156926626	156926626	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:156926626C>A	uc003lwz.2	-	13	1417	c.1353G>T	c.(1351-1353)AGG>AGT	p.R451S	ADAM19_uc003lww.1_Missense_Mutation_p.R184S|ADAM19_uc003lwy.2_Missense_Mutation_p.R50S|ADAM19_uc011ddr.1_Missense_Mutation_p.R382S	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	451	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCGCCCCCGGCCTCAGGGTAC	0.627			NA											6	15					3.59834e-05	4.57629e-05	0.001168	1	0
ADRA1B	147	broad.mit.edu	37	5	159344430	159344430	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:159344430C>G	uc003lxt.1	+	1	691	c.518C>G	c.(517-519)TCC>TGC	p.S173C		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	173	Helical; Name=4; (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	TGGGTCTTGTCCACCGTCATC	0.607			NA											17	27					0	0	0.004007	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179564598	179564598	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:179564598G>T	uc003mlq.2	-	2	589	c.292C>A	c.(292-294)CTG>ATG	p.L98M	RASGEF1C_uc003mlr.2_Missense_Mutation_p.L98M|RASGEF1C_uc003mlp.3_5'Flank	NM_175062	NP_778232	Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	98	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCTTGTCCAGCACCGGCTTG	0.592			NA											8	7					2.17888e-05	2.81911e-05	0.006214	1	0
CDYL	9425	broad.mit.edu	37	6	4943946	4943946	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:4943946G>T	uc003mwi.2	+	7	1581	c.1450G>T	c.(1450-1452)GGC>TGC	p.G484C	CDYL_uc003mwj.2_Missense_Mutation_p.G430C|CDYL_uc003mwk.2_Missense_Mutation_p.G195C|CDYL_uc011dhx.1_Missense_Mutation_p.G298C|CDYL_uc011dhy.1_Missense_Mutation_p.G298C	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	484					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GAGTCCAGATGGCTGTTCTAC	0.408			NA											37	135					5.04308e-16	9.18976e-16	0.00623	1	0
F13A1	2162	broad.mit.edu	37	6	6167690	6167690	+	Splice_Site	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:6167690C>T	uc003mwv.2	-	13	2031	c.1908_splice	c.e13+1	p.K636_splice	F13A1_uc011dib.1_Splice_Site_p.K573_splice	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor						peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTAAGACTGACCTTGATGATG	0.398			NA											11	57					0	0	0.004007	0	0
GCNT2	2651	broad.mit.edu	37	6	10529193	10529193	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:10529193G>T	uc010joo.2	+	3	600	c.49G>T	c.(49-51)GCC>TCC	p.A17S	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.A16S|GCNT2_uc010jon.2_Missense_Mutation_p.A16S	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	17	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TCTTATCTCTGCCCTGATTTT	0.418			NA											21	88					1.64113e-05	2.14193e-05	0.001523	1	0
JARID2	3720	broad.mit.edu	37	6	15487586	15487586	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:15487586A>T	uc003nbj.2	+	6	963	c.719A>T	c.(718-720)AAA>ATA	p.K240I	JARID2_uc011diu.1_Missense_Mutation_p.K104I|JARID2_uc011div.1_Missense_Mutation_p.K68I|JARID2_uc011diw.1_Missense_Mutation_p.K202I	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	240					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CCTGTTCAAAAACACAAAAGC	0.532			NA											18	52					0	0	0.001523	0	0
KIF13A	63971	broad.mit.edu	37	6	17837114	17837114	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:17837114C>G	uc003ncg.3	-	11	1255	c.1150G>C	c.(1150-1152)GCA>CCA	p.A384P	KIF13A_uc003ncf.2_Missense_Mutation_p.A384P|KIF13A_uc003nch.3_Missense_Mutation_p.A384P|KIF13A_uc003nci.3_Missense_Mutation_p.A384P|KIF13A_uc003ncj.2_Missense_Mutation_p.A60P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	384	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTTACCTCTGCCTGAGAGAGC	0.507			NA											57	161					0	0	0.00361	0	0
SLC17A2	10246	broad.mit.edu	37	6	25921632	25921632	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:25921632C>A	uc011dkb.1	-	3	332	c.249G>T	c.(247-249)GTG>GTT	p.V83V	SLC17A2_uc011dkc.1_Silent_p.V83V|SLC17A2_uc003nfl.2_Silent_p.V83V			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	83					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						TCCATTGATACACAGAGGCCT	0.413			NA											6	26					3.59834e-05	4.57629e-05	0.001168	1	0
HIST1H3B	8358	broad.mit.edu	37	6	26031973	26031973	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:26031973C>T	uc003nfs.1	-	1	316	c.316G>A	c.(316-318)GAG>AAG	p.E106K		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TTTGTGTCCTCAAAGAGCCCT	0.542			NA											21	51					0	0	0.001882	0	0
HIST1H2AB	8335	broad.mit.edu	37	6	26033604	26033604	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:26033604C>G	uc003nft.1	-	1	193	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	65					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCCGCCAGCTCCAGGATCTCG	0.637			NA											4	70					0	0	0.001168	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225539	26225539	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:26225539C>A	uc003nhb.2	+	2	517	c.157C>A	c.(157-159)CGT>AGT	p.R53S	HIST1H3E_uc003nhc.3_Missense_Mutation_p.R53S	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	53					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GCGCGAGATCCGTCGCTACCA	0.627			NA											11	45					7.03913e-09	1.07427e-08	0.001368	1	0
HIST1H4F	8361	broad.mit.edu	37	6	26240950	26240950	+	Nonsense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:26240950C>G	uc003nhe.1	+	1	297	c.297C>G	c.(295-297)TAC>TAG	p.Y99*		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	99					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GCACTCTGTACGGCTTTGGTG	0.557			NA											4	42					0	0	0.000248	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27835138	27835138	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:27835138C>A	uc003njx.2	-	1	222	c.170G>T	c.(169-171)CGC>CTC	p.R57L		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	57	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						AAGGCCATTGCGCTCCTTAGA	0.597			NA											25	94					6.32553e-13	1.08773e-12	0.004656	1	0
ZNF192	7745	broad.mit.edu	37	6	28120089	28120089	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:28120089G>T	uc003nkn.1	+	5	886	c.702G>T	c.(700-702)TGG>TGT	p.W234C	ZNF192_uc010jqx.1_Missense_Mutation_p.W234C|ZNF192_uc010jqy.1_Missense_Mutation_p.W47C|ZNF192_uc011dkz.1_Missense_Mutation_p.W47C	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	234	KRAB.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGAGGAGTGGCTTCTTGATC	0.453			NA											22	98					1.10513e-12	1.89069e-12	0.002299	1	0
ZNF187	7741	broad.mit.edu	37	6	28244355	28244355	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:28244355G>T	uc011dld.1	+	5	1189	c.919G>T	c.(919-921)GAG>TAG	p.E307*	ZNF187_uc011dlc.1_Nonsense_Mutation_p.E308*|ZNF187_uc003nku.3_Nonsense_Mutation_p.E173*|ZNF187_uc003nkw.3_Nonsense_Mutation_p.E154*|ZNF187_uc011dle.1_Nonsense_Mutation_p.E154*|ZNF187_uc011dlf.1_Nonsense_Mutation_p.E99*|ZNF187_uc011dlg.1_Nonsense_Mutation_p.E154*	NM_001111039	NP_001104509	Q16670	ZN187_HUMAN	zinc finger protein 187 isoform b	307					viral reproduction	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCATCTTGGTGAGAAGCCTTA	0.443			NA											7	19					8.12818e-05	0.000101263	0.001984	1	0
ZNF323	64288	broad.mit.edu	37	6	28294030	28294030	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:28294030G>C	uc003nla.2	-	4	1534	c.1134C>G	c.(1132-1134)CCC>CCG	p.P378P	ZNF323_uc003nld.2_Silent_p.P378P|ZNF323_uc010jra.2_Silent_p.P378P|ZNF323_uc003nlb.2_Silent_p.P219P|ZNF323_uc010jrb.2_Silent_p.P219P|ZNF323_uc003nlc.2_Silent_p.P378P	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	378					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGCACTGATAGGGTTTCTCAC	0.468	Colon(115;1052 1587 16954 47314 53012)		NA											10	245					0	0	0.008291	0	0
GABBR1	2550	broad.mit.edu	37	6	29591181	29591181	+	Silent	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:29591181T>C	uc003nmt.3	-	8	1200	c.864A>G	c.(862-864)CCA>CCG	p.P288P	GABBR1_uc003nmp.3_Silent_p.P171P|GABBR1_uc003nms.3_Silent_p.P171P|GABBR1_uc003nmu.3_Silent_p.P226P|GABBR1_uc011dlr.1_Silent_p.P111P|GABBR1_uc011dls.1_Silent_p.P288P	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	288	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GTGTGGCTGATGGGTGCGTTC	0.562			NA											16	26					0	0	0.004007	0	0
ZFP57	346171	broad.mit.edu	37	6	29641187	29641187	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:29641187G>T	uc011dlw.1	-	4	852	c.701C>A	c.(700-702)ACG>AAG	p.T234K	ZFP57_uc003nnl.3_Missense_Mutation_p.T214K	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	150	C2H2-type 3.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GTCACAGAGCGTGCAACAGAA	0.562			NA											15	59					2.32078e-09	3.60742e-09	0.003163	1	0
TRIM40	135644	broad.mit.edu	37	6	30104992	30104992	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:30104992G>C	uc003npk.2	+	2	565	c.179G>C	c.(178-180)TGT>TCT	p.C60S	TRIM40_uc003npl.1_RNA|TRIM40_uc003npm.2_Missense_Mutation_p.C60S	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	60						intracellular	zinc ion binding			ovary(1)	1						CGGAAGCCCTGTTCTGAGGAG	0.572			NA											11	34					0	0	0.008291	0	0
MUC21	394263	broad.mit.edu	37	6	30955887	30955887	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:30955887G>T	uc003nsh.2	+	3	1868	c.1617G>T	c.(1615-1617)AGG>AGT	p.R539S	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	539	Cytoplasmic (Potential).|Cytoplasmic tail.					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCCCCCACAGGCCCAGGTGGA	0.597			NA											11	28					1.58986e-06	2.20122e-06	0.008291	1	0
CDSN	1041	broad.mit.edu	37	6	31083934	31083934	+	Nonsense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:31083934A>T	uc003nsm.1	-	2	1485	c.1458T>A	c.(1456-1458)TGT>TGA	p.C486*	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	486					cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						TGCTGGAGCCACAGGGCTTGG	0.617			NA											11	41					0	0	0.001368	0	0
BAT5	7920	broad.mit.edu	37	6	31655057	31655057	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:31655057G>A	uc003nvy.1	-	20	1639	c.1609C>T	c.(1609-1611)CAC>TAC	p.H537Y	BAT5_uc003nvx.1_Missense_Mutation_p.H318Y|BAT5_uc011dny.1_Missense_Mutation_p.H504Y|BAT5_uc003nvz.1_Missense_Mutation_p.H318Y|BAT5_uc011dnz.1_Missense_Mutation_p.H318Y	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	537						integral to membrane	hydrolase activity|protein binding				0						TCAAAGTTGTGCAGATGCTTC	0.602			NA											6	22					0	0	0.001984	0	0
NOTCH4	4855	broad.mit.edu	37	6	32180910	32180910	+	Splice_Site	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:32180910A>T	uc003obb.2	-	15	2577	c.2438_splice	c.e15+1	p.S813_splice	NOTCH4_uc011dpu.1_Splice_Site|NOTCH4_uc011dpv.1_Splice_Site	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein						cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGCCCTGCTCACCTGTCTGCA	0.647			NA											5	37					0	0	0.000602	0	0
C6orf10	10665	broad.mit.edu	37	6	32323447	32323447	+	Splice_Site	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:32323447C>G	uc011dpy.1	-	7	391	c.218_splice	c.e7-1	p.E73_splice	C6orf10_uc011dpz.1_Splice_Site_p.E73_splice	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10							integral to membrane				skin(1)	1						TTGGATCTCTCTGAAAACATA	0.308			NA											3	61					0	0	0.000248	0	0
BTNL2	56244	broad.mit.edu	37	6	32362737	32362737	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:32362737A>G	uc003obg.1	-	6	1144	c.1144T>C	c.(1144-1146)TCT>CCT	p.S382P	BTNL2_uc010jty.1_Missense_Mutation_p.S105P|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.S172P	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	382	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCATCTGAAGAGCACATCGGC	0.577			NA											33	112					0	0	0.002096	0	0
PIM1	5292	broad.mit.edu	37	6	37139014	37139014	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:37139014G>C	uc003onk.2	+	4	784	c.354G>C	c.(352-354)CTG>CTC	p.L118L	PIM1_uc011dtw.1_5'Flank	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	209	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	GTTTCGTCCTGATCCTGGAGA	0.607			NA	T	BCL6	NHL								7	125					0	0	0.001984	0	0
KCNK17	89822	broad.mit.edu	37	6	39267446	39267446	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:39267446C>T	uc003ooo.2	-	5	896	c.756G>A	c.(754-756)GGG>GGA	p.G252G	KCNK17_uc003oop.2_3'UTR	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	252	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						GCCATGCCATCCCAAAGAGGA	0.562			NA											19	92					0	0	0.001216	0	0
TREML2	79865	broad.mit.edu	37	6	41162309	41162309	+	Silent	SNP	C	C	T	rs143539514		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:41162309C>T	uc010jxm.1	-	3	818	c.639G>A	c.(637-639)GCG>GCA	p.A213A		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	213	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCTGGGAGACGCGGTCACTG	0.627			NA											5	30					0	0	0.000602	0	0
FOXP4	116113	broad.mit.edu	37	6	41533600	41533600	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:41533600C>A	uc003oql.2	+	2	560	c.102C>A	c.(100-102)GCC>GCA	p.A34A	FOXP4_uc003oqm.2_Silent_p.A34A|FOXP4_uc003oqn.2_Silent_p.A34A	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	34					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					GCGGCGGGGCCACAGGGACAA	0.622			NA											25	69					4.02929e-09	6.24144e-09	0.002096	1	0
SLC22A7	10864	broad.mit.edu	37	6	43271888	43271888	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:43271888G>T	uc003out.2	+	10	1597	c.1498G>T	c.(1498-1500)GGG>TGG	p.G500W	SLC22A7_uc003ous.2_Missense_Mutation_p.G498W	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	500	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			TACTTATGGGGGGATCGCCCT	0.662			NA											32	87					8.16721e-17	1.50874e-16	0.002096	1	0
CAPN11	11131	broad.mit.edu	37	6	44144372	44144372	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:44144372G>T	uc003owt.1	+	10	1094	c.1056G>T	c.(1054-1056)AAG>AAT	p.K352N	CAPN11_uc011dvn.1_Missense_Mutation_p.K6N	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	352	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGCACAAGACGGAGGACG	0.627			NA											11	45					3.07112e-06	4.16617e-06	0.000978	1	0
TCTE1	202500	broad.mit.edu	37	6	44254012	44254012	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:44254012C>G	uc003oxi.2	-	3	691	c.535G>C	c.(535-537)GAC>CAC	p.D179H	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	179										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGCAGCAGGTCGAGGATCACC	0.647			NA											5	30					0	0	0.000602	0	0
GPR111	222611	broad.mit.edu	37	6	47646726	47646726	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:47646726C>T	uc010jzj.1	+	4	328	c.327C>T	c.(325-327)TGC>TGT	p.C109C	GPR111_uc010jzk.1_Silent_p.C41C|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	109	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CAGGTGTATGCGATGGTGTCT	0.517			NA											12	55					0	0	0.001855	0	0
C6orf138	442213	broad.mit.edu	37	6	47847488	47847488	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:47847488C>A	uc011dwm.1	-	3	1126	c.1041G>T	c.(1039-1041)GTG>GTT	p.V347V	C6orf138_uc011dwn.1_Silent_p.V111V	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	364	SSD.					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						AGAAGACCTTCACAGCCTCTA	0.458			NA											6	37					2.0095e-06	2.76512e-06	0.001984	1	0
DEFB110	245913	broad.mit.edu	37	6	49986727	49986727	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:49986727C>A	uc003pac.2	-	2	213	c.167G>T	c.(166-168)TGC>TTC	p.C56F	DEFB110_uc011dwr.1_Intron	NM_001037497	NP_001032586	Q30KQ9	DB110_HUMAN	beta-defensin 110 isoform a	56					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					AGGTCTTATGCAGTAAGCAAT	0.408			NA											10	45					1.76689e-08	2.64247e-08	0.006214	1	0
TFAP2D	83741	broad.mit.edu	37	6	50686838	50686838	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:50686838T>A	uc003paf.2	+	3	1085	c.573T>A	c.(571-573)AAT>AAA	p.N191K	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	191							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					TTGTTCTCAATGGCCAAGGTG	0.388			NA											10	17					0	0	0.001855	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791195	50791195	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:50791195A>T	uc003pag.2	+	2	323	c.157A>T	c.(157-159)AGC>TGC	p.S53C		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	53	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					ACCCTACTCGAGCGCCCCGCC	0.652	Pancreas(116;1373 2332 5475 10752)		NA											5	19					0	0	0.000602	0	0
PKHD1	5314	broad.mit.edu	37	6	51777291	51777292	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:51777291_51777292CC>AA	uc003pah.1	-	38	6480_6481	c.6204_6205GG>TT	c.(6202-6207)GTGGAC>GTTTAC	p.D2069Y	PKHD1_uc010jzn.1_Missense_Mutation_p.D94Y|PKHD1_uc003pai.2_Missense_Mutation_p.D2069Y	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2069	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGGTTCCAGTCCACAGCATCTT	0.49			NA											22	102					0	0	0.004672	0	0
PKHD1	5314	broad.mit.edu	37	6	51935236	51935236	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:51935236C>A	uc003pah.1	-	10	951	c.675G>T	c.(673-675)CAG>CAT	p.Q225H	PKHD1_uc003pai.2_Missense_Mutation_p.Q225H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	225	IPT/TIG 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGCTAACATTCTGGGAGCCTG	0.388			NA											15	27					4.7546e-09	7.32274e-09	0.004007	1	0
C6orf142	90523	broad.mit.edu	37	6	53986316	53986316	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:53986316C>A	uc003pcg.3	+	2	248	c.135C>A	c.(133-135)ACC>ACA	p.T45T	C6orf142_uc003pcf.2_Silent_p.T45T|C6orf142_uc003pch.3_Intron|C6orf142_uc011dwz.1_Intron|C6orf142_uc011dxa.1_Silent_p.T56T	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	45						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					GACTACCAACCCATACTCAGT	0.393			NA											27	82					5.45727e-16	9.89084e-16	0.008361	1	0
FAM83B	222584	broad.mit.edu	37	6	54806636	54806636	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:54806636C>A	uc003pck.2	+	5	2983	c.2867C>A	c.(2866-2868)ACC>AAC	p.T956N		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	956										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ATGCCAAATACCAGTATAAAT	0.413			NA											17	56					9.16793e-09	1.38968e-08	0.00499	1	0
HCRTR2	3062	broad.mit.edu	37	6	55142304	55142304	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:55142304C>G	uc003pcl.2	+	5	1204	c.889C>G	c.(889-891)CGA>GGA	p.R297G	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	297	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAAGCAGATCCGAGCCAGAAG	0.493			NA											6	29					0	0	0.001168	0	0
DST	667	broad.mit.edu	37	6	56504830	56504830	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:56504830C>A	uc003pdf.2	-	18	2445	c.2417G>T	c.(2416-2418)GGC>GTC	p.G806V	DST_uc003pcz.3_Missense_Mutation_p.G628V|DST_uc011dxj.1_Missense_Mutation_p.G657V|DST_uc011dxk.1_Missense_Mutation_p.G668V|DST_uc011dxl.1_Missense_Mutation_p.G657V|DST_uc003pcy.3_Missense_Mutation_p.G302V|DST_uc003pdb.2_Missense_Mutation_p.G302V|DST_uc003pdc.3_Missense_Mutation_p.G302V|DST_uc003pdd.3_Missense_Mutation_p.G302V|DST_uc003pde.2_Missense_Mutation_p.G744V	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	628					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CAAATCTGAGCCCCACTCAGT	0.333			NA											20	55					1.50039e-11	2.49693e-11	0.001882	1	0
EYS	346007	broad.mit.edu	37	6	66205175	66205175	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:66205175C>A	uc011dxu.1	-	4	667	c.129G>T	c.(127-129)TGG>TGT	p.W43C	EYS_uc003peq.2_Missense_Mutation_p.W43C|EYS_uc003per.1_Missense_Mutation_p.W43C|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	43					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CTGTTAGTGTCCAATTTACCA	0.408			NA											33	110					4.62619e-21	8.95241e-21	0.004289	1	0
BAI3	577	broad.mit.edu	37	6	70049390	70049390	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:70049390G>T	uc003pev.3	+	26	3901	c.3453G>T	c.(3451-3453)CGG>CGT	p.R1151R	BAI3_uc010kak.2_Silent_p.R1151R|BAI3_uc011dxx.1_Silent_p.R357R|BAI3_uc003pex.1_Silent_p.R281R	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1151	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GCATTCTTCGGAGAGAGGTGA	0.368			NA											37	116					1.60099e-16	2.94537e-16	0.004878	1	0
COL19A1	1310	broad.mit.edu	37	6	70639516	70639516	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:70639516C>A	uc003pfc.1	+	6	707	c.590C>A	c.(589-591)ACT>AAT	p.T197N	COL19A1_uc010kam.1_Missense_Mutation_p.T93N	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	197	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AGGAGGCAGACTGATGAAAAG	0.428			NA											20	62					1.01871e-10	1.65433e-10	0.001216	1	0
SNX14	57231	broad.mit.edu	37	6	86243356	86243356	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:86243356C>T	uc003pkr.2	-	18	1964	c.1771G>A	c.(1771-1773)GTG>ATG	p.V591M	SNX14_uc003pkp.2_Missense_Mutation_p.V454M|SNX14_uc003pkq.2_Missense_Mutation_p.V197M|SNX14_uc011dzg.1_Missense_Mutation_p.V539M|SNX14_uc003pks.2_Missense_Mutation_p.V538M|SNX14_uc003pkt.2_Missense_Mutation_p.V582M	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	591	PX.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ATACAAAACACAGGAATTCTT	0.388			NA											11	58					0	0	0.008291	0	0
HTR1E	3354	broad.mit.edu	37	6	87726017	87726017	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:87726017C>A	uc003pli.2	+	2	1668	c.965C>A	c.(964-966)TCC>TAC	p.S322Y		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	322	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TACACCGTGTCCTCGGAAGTG	0.473			NA											34	187					3.76114e-14	6.67266e-14	0.004289	1	0
HTR1E	3354	broad.mit.edu	37	6	87726077	87726077	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:87726077T>A	uc003pli.2	+	2	1728	c.1025T>A	c.(1024-1026)CTG>CAG	p.L342Q		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	342	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATCAACCCTCTGCTCTATACG	0.433			NA											48	120					0	0	0.003214	0	0
GABRR1	2569	broad.mit.edu	37	6	89909117	89909117	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:89909117C>G	uc003pna.2	-	4	767	c.312G>C	c.(310-312)CAG>CAC	p.Q104H	GABRR1_uc011dzv.1_Missense_Mutation_p.Q81H	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	104	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AACTCTCCACCTGCACATCCA	0.488			NA											10	38					0	0	0.001368	0	0
FHL5	9457	broad.mit.edu	37	6	97063629	97063629	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:97063629G>T	uc003pos.1	+	7	1241	c.836G>T	c.(835-837)GGA>GTA	p.G279V	FHL5_uc003pot.1_Missense_Mutation_p.G279V	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	279	LIM zinc-binding 4.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TGTGGCTCCGGAATGGACACT	0.468			NA											8	39					1.06961e-07	1.55129e-07	0.00308	1	0
C6orf168	84553	broad.mit.edu	37	6	99729269	99729269	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:99729269C>A	uc003ppj.3	-	6	1284	c.1001G>T	c.(1000-1002)TGG>TTG	p.W334L	C6orf168_uc003ppi.3_Missense_Mutation_p.W54L	NM_032511	NP_115900	Q5TGI0	CF168_HUMAN	hypothetical protein LOC84553	334										ovary(2)|central_nervous_system(1)	3		all_cancers(76;1.63e-06)|Acute lymphoblastic leukemia(125;5.12e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00898)|Colorectal(196;0.0699)|Lung NSC(302;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.073)		ATCGTGGTGCCACTCTGGCCA	0.483			NA											25	81					4.59853e-10	7.31733e-10	0.005443	1	0
ASCC3	10973	broad.mit.edu	37	6	100960595	100960596	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:100960595_100960596CC>AA	uc003pqk.2	-	40	6603_6604	c.6274_6275GG>TT	c.(6274-6276)GGG>TTG	p.G2092L		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	2092					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTTGTGGAACCCAAAGTGGACT	0.431			NA											17	52					0	0	0.004672	0	0
ASCC3	10973	broad.mit.edu	37	6	100965956	100965956	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:100965956C>G	uc003pqk.2	-	38	6167	c.5838G>C	c.(5836-5838)CTG>CTC	p.L1946L		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1946	SEC63 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CCATCTGAATCAGGTTGGTGA	0.433			NA											20	58					0	0	0.001216	0	0
HACE1	57531	broad.mit.edu	37	6	105300216	105300216	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:105300216G>A	uc003pqu.1	-	2	384	c.107C>T	c.(106-108)CCA>CTA	p.P36L	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.P36L	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	36					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CATAACCATTGGCATTAATGT	0.343			NA											10	32					0	0	0.008291	0	0
BVES	11149	broad.mit.edu	37	6	105564715	105564715	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:105564715C>A	uc003pqw.2	-	6	834	c.677G>T	c.(676-678)AGA>ATA	p.R226I	BVES_uc003pqx.2_Missense_Mutation_p.R226I|BVES_uc003pqy.2_Missense_Mutation_p.R226I	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	226	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GCATAAAAATCTGCAGTTATC	0.313			NA											8	39					0.000274275	0.000331549	0.004482	1	0
BEND3	57673	broad.mit.edu	37	6	107390010	107390010	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:107390010C>T	uc003prs.2	-	5	3035	c.2385G>A	c.(2383-2385)GAG>GAA	p.E795E		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	795	BEN 4.									ovary(3)	3						AGTGCCACACCTCCTCCATCT	0.567			NA											24	76					0	0	0.00278	0	0
ZBTB24	9841	broad.mit.edu	37	6	109802996	109802996	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:109802996C>G	uc003ptl.1	-	2	402	c.234G>C	c.(232-234)ATG>ATC	p.M78I	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.M78I|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.M78I	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	78	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TGCCTTCCAGCATATAAATGG	0.448			NA											11	57					0	0	0.001368	0	0
FIG4	9896	broad.mit.edu	37	6	110112626	110112626	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:110112626C>T	uc003ptt.2	+	20	2443	c.2228C>T	c.(2227-2229)GCC>GTC	p.A743V	FIG4_uc011eau.1_Missense_Mutation_p.A466V	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	743					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		AAAACGGCAGCCAGCGCCCCG	0.517			NA											16	152					0	0	0.001523	0	0
ZUFSP	221302	broad.mit.edu	37	6	116956996	116956996	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:116956996C>T	uc003pxf.1	-	10	1982	c.1736G>A	c.(1735-1737)TGA>TAA	p.*579*		NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	579						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		CTTGATTCTTCAAGGAATCTT	0.294			NA											12	67					0	0	0.001855	0	0
ROS1	6098	broad.mit.edu	37	6	117677813	117677813	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:117677813T>A	uc003pxp.1	-	25	4319	c.4120A>T	c.(4120-4122)ATC>TTC	p.I1374F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1374	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGTACTGTGATAACTCTCCAA	0.433			NA	T	GOPC|ROS1	glioblastoma|NSCLC								13	42					0	0	0.001855	0	0
CLVS2	134829	broad.mit.edu	37	6	123319180	123319180	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:123319180C>G	uc003pzi.1	+	2	1127	c.258C>G	c.(256-258)TTC>TTG	p.F86L		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	86					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGGACATGTTCAAAAGCTTTA	0.547			NA											27	84					0	0	0.007291	0	0
ENPP1	5167	broad.mit.edu	37	6	132173372	132173372	+	Missense_Mutation	SNP	C	C	T	rs145868241	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:132173372C>T	uc011ecf.1	+	5	634	c.614C>T	c.(613-615)GCA>GTA	p.A205V		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	205	Phosphodiesterase.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CAGTGCCCAGCAGGGTAAGAT	0.294	Colon(104;336 1535 5856 11019 33782)		NA											17	58					0	0	0.00499	0	0
TAAR9	134860	broad.mit.edu	37	6	132860367	132860367	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:132860367C>A	uc011eci.1	+	2	941	c.939C>A	c.(937-939)TTC>TTA	p.F313L		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	313	Helical; Name=7; (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TTTATGCTTTCTTTTACCAAT	0.318	Colon(10;433 445 15992 45047 47213)		NA											8	25					0.000157383	0.000191976	0.00308	1	0
TAAR8	83551	broad.mit.edu	37	6	132873990	132873990	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:132873990G>A	uc011ecj.1	+	1	159	c.159G>A	c.(157-159)ATG>ATA	p.M53I		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	53	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		TCTTAGTAATGACTTCTGTTC	0.448			NA											48	184					0	0	0.00361	0	0
TAAR8	83551	broad.mit.edu	37	6	132874129	132874129	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:132874129G>T	uc011ecj.1	+	1	298	c.298G>T	c.(298-300)GGA>TGA	p.G100*		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	100	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CTGGTATTTTGGAGCCAAATT	0.468			NA											18	138					5.01169e-05	6.31398e-05	0.00499	1	0
HIVEP2	3097	broad.mit.edu	37	6	143092296	143092296	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:143092296C>G	uc003qjd.2	-	5	4323	c.3580G>C	c.(3580-3582)GAG>CAG	p.E1194Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGAATTGTCTCTTGATGTGGA	0.433	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											22	132					0	0	0.00333	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093208	143093208	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:143093208C>G	uc003qjd.2	-	5	3411	c.2668G>C	c.(2668-2670)GAG>CAG	p.E890Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	890					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACTCGAATCTCAGGAACCTGG	0.547	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											8	56					0	0	0.006214	0	0
GRM1	2911	broad.mit.edu	37	6	146719922	146719922	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:146719922G>C	uc010khw.1	+	8	2217	c.1747G>C	c.(1747-1749)GTG>CTG	p.V583L	GRM1_uc010khv.1_Missense_Mutation_p.V583L|GRM1_uc003qll.2_Missense_Mutation_p.V583L|GRM1_uc011edz.1_Missense_Mutation_p.V583L|GRM1_uc011eea.1_Missense_Mutation_p.V583L	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	583	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCCCATTCCTGTGCGCTATCT	0.428			NA											43	192					0	0	0.003214	0	0
AKAP12	9590	broad.mit.edu	37	6	151673998	151673998	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:151673998C>T	uc011eep.1	+	4	4712	c.4472C>T	c.(4471-4473)ACT>ATT	p.T1491I	AKAP12_uc003qoe.2_Missense_Mutation_p.T1491I|AKAP12_uc003qof.2_Missense_Mutation_p.T1393I|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.T1386I	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1491					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GTATCTGCTACTACCAAGAAA	0.498	Melanoma(141;1616 1805 10049 24534 51979)		NA											10	67					0	0	0.008291	0	0
C6orf97	80129	broad.mit.edu	37	6	151936691	151936691	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:151936691G>A	uc003qol.2	+	10	1913	c.1824G>A	c.(1822-1824)CTG>CTA	p.L608L		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	608	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AGTCAGAACTGGATACCACAG	0.398			NA											36	93					0	0	0.005524	0	0
SYNE1	23345	broad.mit.edu	37	6	152754989	152754989	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:152754989C>A	uc010kiw.2	-	34	5004	c.4402G>T	c.(4402-4404)GAA>TAA	p.E1468*	SYNE1_uc003qot.3_Nonsense_Mutation_p.E1475*|SYNE1_uc003qou.3_Nonsense_Mutation_p.E1468*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.E1451*|SYNE1_uc003qow.2_Nonsense_Mutation_p.E763*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1468	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCATTGAGTTCTTTTTCTTTC	0.373			NA								HNSCC(10;0.0054)			13	50					4.3838e-07	6.19079e-07	0.001855	1	0
MYCT1	80177	broad.mit.edu	37	6	153042943	153042943	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:153042943C>A	uc003qpd.3	+	2	271	c.263C>A	c.(262-264)GCT>GAT	p.A88D	MYCT1_uc010kjc.1_Missense_Mutation_p.A88D|MYCT1_uc003qpc.3_Missense_Mutation_p.A88D	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	88						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TTTATTTGGGCTGTGTTCATT	0.448			NA											22	84					1.37878e-21	2.68363e-21	0.00333	1	0
OPRM1	4988	broad.mit.edu	37	6	154412483	154412483	+	Missense_Mutation	SNP	G	G	C	rs77013544		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:154412483G>C	uc003qpr.2	+	3	1277	c.1040G>C	c.(1039-1041)CGA>CCA	p.R347P	OPRM1_uc011efc.1_Missense_Mutation_p.R266P|OPRM1_uc011efd.1_Missense_Mutation_p.R247P|OPRM1_uc011efe.1_Missense_Mutation_p.R440P|OPRM1_uc003qpn.2_Missense_Mutation_p.R347P|OPRM1_uc003qpo.1_Missense_Mutation_p.R347P|OPRM1_uc011eff.1_Missense_Mutation_p.R347P|OPRM1_uc011efg.1_Missense_Mutation_p.R347P|OPRM1_uc011efh.1_Missense_Mutation_p.R347P|OPRM1_uc003qpq.1_Missense_Mutation_p.R347P|OPRM1_uc003qpt.1_Missense_Mutation_p.R347P|OPRM1_uc011efi.1_Missense_Mutation_p.R347P|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Missense_Mutation_p.R247P|OPRM1_uc003qpu.2_Missense_Mutation_p.R247P	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	347	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	AACTTCAAACGATGCTTCAGA	0.463			NA											5	80					0	0	0.000602	0	0
TAGAP	117289	broad.mit.edu	37	6	159457615	159457615	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:159457615G>A	uc003qrz.2	-	10	1772	c.1440C>T	c.(1438-1440)CCC>CCT	p.P480P	TAGAP_uc011eft.1_Silent_p.P417P|TAGAP_uc003qsa.2_Silent_p.P302P	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AATTTCTTTTGGGACTGGAAG	0.537			NA											32	172					0	0	0.002836	0	0
SLC22A2	6582	broad.mit.edu	37	6	160666574	160666574	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:160666574G>A	uc003qtf.2	-	6	1131	c.961C>T	c.(961-963)CTG>TTG	p.L321L	SLC22A2_uc003qte.1_Silent_p.L321L	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	321	Cytoplasmic (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TCAAGTCTCAGGCGCTAAGAA	0.403			NA											6	24					0	0	0.001984	0	0
PLG	5340	broad.mit.edu	37	6	161160109	161160109	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:161160109G>C	uc003qtm.3	+	16	1950	c.1887G>C	c.(1885-1887)AGG>AGC	p.R629S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	629	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGTCCCCAAGGCCTTCATCCT	0.507			NA											24	89					0	0	0.003954	0	0
PLG	5340	broad.mit.edu	37	6	161160215	161160215	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:161160215G>T	uc003qtm.3	+	16	2056	c.1993G>T	c.(1993-1995)GAT>TAT	p.D665Y		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	665	Peptidase S1.	Charge relay system.			extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CACACGAAAAGATATTGCCTT	0.478			NA											21	78					2.52088e-20	4.85034e-20	0.00278	1	0
THBS2	7058	broad.mit.edu	37	6	169648580	169648580	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:169648580C>T	uc003qwt.2	-	4	789	c.541G>A	c.(541-543)GAG>AAG	p.E181K		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	181	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TGCAGGTGCTCGTAGAAGGGC	0.622	Esophageal Squamous(91;219 1934 18562 44706)		NA											17	58					0	0	0.006122	0	0
SDK1	221935	broad.mit.edu	37	7	4089047	4089047	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:4089047G>C	uc003smx.2	+	18	2809	c.2670G>C	c.(2668-2670)TGG>TGC	p.W890C	SDK1_uc010kso.2_Missense_Mutation_p.W166C	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	890	Fibronectin type-III 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTTCCTGTGGAACCCTCCGC	0.592			NA											9	33					0	0	0.008291	0	0
SLC29A4	222962	broad.mit.edu	37	7	5327577	5327577	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:5327577G>A	uc003sod.2	+	2	291	c.130G>A	c.(130-132)GGC>AGC	p.G44S	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.G44S|SLC29A4_uc003soe.2_Missense_Mutation_p.G44S	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	44	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TCAGGGCCAGGGCCTTAGGGC	0.667			NA											6	30					0	0	0.00308	0	0
ACTB	60	broad.mit.edu	37	7	5567507	5567507	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:5567507C>T	uc003sos.3	-	5	1036	c.1000G>A	c.(1000-1002)GAG>AAG	p.E334K	ACTB_uc003sor.3_Missense_Mutation_p.E212K|ACTB_uc003sot.3_Missense_Mutation_p.E334K|ACTB_uc003soq.3_Missense_Mutation_p.E212K|ACTB_uc010ksy.2_Missense_Mutation_p.E212K	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	334					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TACTTGCGCTCAGGAGGAGCA	0.627			NA											10	81					0	0	0.008291	0	0
PHF14	9678	broad.mit.edu	37	7	11068443	11068443	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:11068443G>C	uc003sry.1	+	7	1888	c.1453G>C	c.(1453-1455)GAG>CAG	p.E485Q	PHF14_uc011jxi.1_Missense_Mutation_p.E200Q|PHF14_uc003srz.2_Missense_Mutation_p.E485Q|PHF14_uc011jxj.1_Missense_Mutation_p.E200Q	NM_014660	NP_055475	O94880	PHF14_HUMAN	PHD finger protein 14 isoform 2	485							zinc ion binding			kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		AGCGGCGGAAGAGGTAGGTTT	0.398			NA											4	54					0	0	0.001168	0	0
BZW2	28969	broad.mit.edu	37	7	16714111	16714111	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:16714111C>T	uc003stl.2	+	3	311	c.133C>T	c.(133-135)CTT>TTT	p.L45F	BZW2_uc011jxx.1_5'UTR|BZW2_uc003stm.2_5'UTR|BZW2_uc003stj.2_Missense_Mutation_p.L45F|BZW2_uc003stk.2_5'UTR|BZW2_uc003stn.1_Missense_Mutation_p.L45F|BZW2_uc003sto.1_5'UTR|BZW2_uc003stp.2_5'UTR|BZW2_uc010kua.2_Missense_Mutation_p.L45F	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	45					cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		TGGTGATGACCTTGAAGCTGT	0.423			NA											22	85					0	0	0.00278	0	0
ITGB8	3696	broad.mit.edu	37	7	20441723	20441723	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:20441723C>T	uc003suu.2	+	10	2366	c.1661C>T	c.(1660-1662)CCA>CTA	p.P554L	ITGB8_uc011jyh.1_Missense_Mutation_p.P419L	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	554	III.|Cysteine-rich tandem repeats.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TTTTCTTGTCCATATCACCAT	0.358			NA											8	74					0	0	0.006214	0	0
DNAH11	8701	broad.mit.edu	37	7	21723472	21723472	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:21723472G>A	uc003svc.2	+	33	5583	c.5552G>A	c.(5551-5553)TGC>TAC	p.C1851Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1851	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGAAACACTGCTTTGTTAAT	0.438			NA							Kartagener_syndrome				18	152					0	0	0.001216	0	0
GPNMB	10457	broad.mit.edu	37	7	23313811	23313811	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:23313811C>A	uc003swc.2	+	11	1848	c.1687C>A	c.(1687-1689)CTC>ATC	p.L563I	GPNMB_uc003swb.2_Missense_Mutation_p.L551I|GPNMB_uc011jyy.1_Missense_Mutation_p.L505I|GPNMB_uc011jyz.1_Missense_Mutation_p.L452I	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	563	Cytoplasmic (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			GGATCCGCTACTCAAAAACCA	0.438			NA											10	82					2.17888e-05	2.81911e-05	0.006214	1	0
STK31	56164	broad.mit.edu	37	7	23808719	23808719	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:23808719G>T	uc003sws.3	+	12	1589	c.1522G>T	c.(1522-1524)GAG>TAG	p.E508*	STK31_uc003swt.3_Nonsense_Mutation_p.E485*|STK31_uc011jze.1_Nonsense_Mutation_p.E508*|STK31_uc010kuq.2_Nonsense_Mutation_p.E485*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	508							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TAAAAGAGAGGAGTTCACCAG	0.408			NA											33	58					1.71298e-08	2.5733e-08	0.003755	1	0
HOXA5	3202	broad.mit.edu	37	7	27182767	27182767	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:27182767G>T	uc003syn.1	-	1	521	c.460C>A	c.(460-462)CCT>ACT	p.P154T		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	154					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGCTGGCAGGGGCGTCCTCC	0.706	Colon(119;75 2200 7557 42868)		NA											13	65					1.5842e-08	2.38251e-08	0.001855	1	0
CHN2	1124	broad.mit.edu	37	7	29535575	29535575	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:29535575C>A	uc003szz.2	+	8	1099	c.662C>A	c.(661-663)ACG>AAG	p.T221K	CHN2_uc011jzs.1_Missense_Mutation_p.T296K|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.T186K|CHN2_uc011jzt.1_Missense_Mutation_p.T234K|CHN2_uc010kvd.2_Missense_Mutation_p.T77K|CHN2_uc011jzu.1_Missense_Mutation_p.T206K|CHN2_uc010kvg.2_Missense_Mutation_p.T85K|CHN2_uc010kvh.2_Missense_Mutation_p.T85K|CHN2_uc010kvi.2_Missense_Mutation_p.T85K|CHN2_uc010kve.2_Missense_Mutation_p.T85K|CHN2_uc003taa.2_Missense_Mutation_p.T85K|CHN2_uc010kvf.2_Missense_Mutation_p.T85K|CHN2_uc010kvj.2_Missense_Mutation_p.T40K|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_Intron|CHN2_uc010kvm.2_Missense_Mutation_p.T40K|CHN2_uc011jzv.1_Missense_Mutation_p.T14K	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	221	Phorbol-ester/DAG-type.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CAGGTCCACACGTTCCGAGGC	0.483	Ovarian(1;44 48 13232 18918 31480)		NA											12	21					0.00010058	0.000124382	0.001368	1	0
SCRN1	9805	broad.mit.edu	37	7	29980355	29980355	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:29980355G>C	uc010kvp.2	-	4	886	c.682C>G	c.(682-684)CCA>GCA	p.P228A	SCRN1_uc011jzy.1_Missense_Mutation_p.P160A|SCRN1_uc003tak.2_Missense_Mutation_p.P228A|SCRN1_uc011jzz.1_Missense_Mutation_p.P228A|SCRN1_uc011kaa.1_Missense_Mutation_p.P248A|SCRN1_uc011jzw.1_Intron|SCRN1_uc011jzx.1_Missense_Mutation_p.P51A	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	228					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						TCCTCAACTGGAGAAAAGACT	0.488			NA											4	100					0	0	0.000602	0	0
SCRN1	9805	broad.mit.edu	37	7	29980412	29980412	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:29980412G>C	uc010kvp.2	-	4	829	c.625C>G	c.(625-627)CAG>GAG	p.Q209E	SCRN1_uc011jzy.1_Missense_Mutation_p.Q141E|SCRN1_uc003tak.2_Missense_Mutation_p.Q209E|SCRN1_uc011jzz.1_Missense_Mutation_p.Q209E|SCRN1_uc011kaa.1_Missense_Mutation_p.Q229E|SCRN1_uc011jzw.1_Intron|SCRN1_uc011jzx.1_Missense_Mutation_p.Q32E	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	209					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						CCTTGGCTCTGAGCGTAACTC	0.527			NA											3	131					0	0	0.000602	0	0
AQP1	358	broad.mit.edu	37	7	30951831	30951831	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:30951831G>T	uc003tbv.1	+	1	364	c.307G>T	c.(307-309)GTG>TTG	p.V103L	AQP1_uc011kac.1_Missense_Mutation_p.V163L	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	103	Helical; Name=Helix 3.				ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	CGCCCAGTGCGTGGGGGCCAT	0.642			NA											22	78					3.5997e-14	6.3947e-14	0.002299	1	0
BBS9	27241	broad.mit.edu	37	7	33545098	33545098	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:33545098G>A	uc003tdn.1	+	20	2652	c.2139G>A	c.(2137-2139)GTG>GTA	p.V713V	BBS9_uc003tdo.1_Silent_p.V678V|BBS9_uc003tdp.1_Silent_p.V708V|BBS9_uc003tdq.1_Silent_p.V673V|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Silent_p.V237V|BBS9_uc003tds.1_Silent_p.V136V|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	713					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			CAGATGCAGTGGAGGAAAACC	0.453			NA							Bardet-Biedl_syndrome				21	141					0	0	0.001882	0	0
BMPER	168667	broad.mit.edu	37	7	34118542	34118542	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:34118542G>T	uc011kap.1	+	12	1266	c.1152G>T	c.(1150-1152)GGG>GGT	p.G384G		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	384	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						ACTTTCAGGGGACGTGTCAGT	0.572			NA											18	98					9.16793e-09	1.38968e-08	0.00499	1	0
INHBA	3624	broad.mit.edu	37	7	41739731	41739731	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:41739731G>T	uc003thq.2	-	1	477	c.242C>A	c.(241-243)GCG>GAG	p.A81E	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.A81E|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	81					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CAGAAGCGCCGCCTTGGGTAC	0.527			NA								TSP Lung(11;0.080)			117	315					3.3835e-51	6.8745e-51	0.00361	1	0
GLI3	2737	broad.mit.edu	37	7	42012087	42012087	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:42012087G>T	uc011kbh.1	-	13	2043	c.1952C>A	c.(1951-1953)CCA>CAA	p.P651Q	GLI3_uc011kbg.1_Missense_Mutation_p.P592Q	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	651					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TCTCGGGGGTGGCGGCCGAGG	0.612			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				15	83					3.52763e-06	4.77101e-06	0.00499	1	0
ADCY1	107	broad.mit.edu	37	7	45688397	45688397	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:45688397G>T	uc003tne.3	+	5	1166	c.1148_splice	c.e5+1	p.T383_splice	ADCY1_uc003tnd.2_Splice_Site_p.T158_splice	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ATACCATCACGTAAGTACCCC	0.587			NA											18	25					5.03518e-11	8.26681e-11	0.007413	1	0
IGFBP3	3486	broad.mit.edu	37	7	45956825	45956825	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:45956825C>T	uc003tns.2	-	2	749	c.617G>A	c.(616-618)CGG>CAG	p.R206Q	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Missense_Mutation_p.R212Q|IGFBP3_uc003tnt.2_Missense_Mutation_p.R109Q	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	206	Ser/Thr-rich.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	TTCTGTCTCCCGCTTGGACTC	0.493			NA									OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	97					0	0	0.001368	0	0
PKD1L1	168507	broad.mit.edu	37	7	47866973	47866973	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:47866973C>T	uc003tny.1	-	45	6829	c.6829G>A	c.(6829-6831)GAG>AAG	p.E2277K	C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Missense_Mutation_p.E4K	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2277	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTGCGACTCTCTCTCCTCATC	0.662			NA											13	35					0	0	0.00245	0	0
ABCA13	154664	broad.mit.edu	37	7	48315431	48315431	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:48315431A>G	uc003toq.2	+	17	6193	c.6168A>G	c.(6166-6168)GAA>GAG	p.E2056E	ABCA13_uc010kyr.2_Silent_p.E1559E	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2056					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACAACTTTGAAGAACTATGGC	0.338			NA											9	30					0	0	0.004482	0	0
TRIM50	135892	broad.mit.edu	37	7	72727283	72727283	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:72727283G>A	uc010lbd.1	-	7	1223	c.1098C>T	c.(1096-1098)ATC>ATT	p.I366I	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Silent_p.I366I|TRIM50_uc003txz.1_Silent_p.I365I	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	366	B30.2/SPRY.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						CTGTGCCCTTGATGACCCCCA	0.672			NA											3	8					0	0	0.004672	0	0
CLIP2	7461	broad.mit.edu	37	7	73790803	73790803	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:73790803A>T	uc003uam.2	+	10	2399	c.2072A>T	c.(2071-2073)GAG>GTG	p.E691V	CLIP2_uc003uan.2_Missense_Mutation_p.E656V|CLIP2_uc003uao.2_Missense_Mutation_p.E85V	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	691	Potential.					microtubule associated complex				skin(3)	3						AAGCTGCAGGAGGCCCAGGAG	0.672			NA											5	18					0	0	0.000602	0	0
GTF2I	2969	broad.mit.edu	37	7	74114663	74114663	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:74114663C>T	uc003uau.2	+	5	830	c.460C>T	c.(460-462)CCG>TCG	p.P154S	GTF2I_uc003uat.2_Missense_Mutation_p.P154S|GTF2I_uc003uav.2_Missense_Mutation_p.P154S|GTF2I_uc003uaw.2_Missense_Mutation_p.P154S|GTF2I_uc003uay.2_Missense_Mutation_p.P154S|GTF2I_uc003uax.2_Missense_Mutation_p.P154S|uc003uaz.2_RNA	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	154	GTF2I-like 1.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						GCAGGGGCTTCCGGAAGGTGT	0.483			NA											9	162					0	0	0.000978	0	0
HGF	3082	broad.mit.edu	37	7	81381508	81381508	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:81381508C>T	uc003uhl.2	-	5	718	c.553G>A	c.(553-555)GGG>AGG	p.G185R	HGF_uc003uhm.2_Missense_Mutation_p.G180R|HGF_uc003uhn.1_Missense_Mutation_p.G185R|HGF_uc003uho.1_Missense_Mutation_p.G180R|HGF_uc003uhp.2_Missense_Mutation_p.G185R	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	185	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CAGGGTCCCCCTTCTTCCCCT	0.448			NA											18	55					0	0	0.001216	0	0
CACNA2D1	781	broad.mit.edu	37	7	81593551	81593551	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:81593551T>C	uc003uhr.1	-	33	2955	c.2699A>G	c.(2698-2700)CAA>CGA	p.Q900R	CACNA2D1_uc011kgy.1_Missense_Mutation_p.Q112R	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	912	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TCCTGCTCCTTGTTTTGGTGC	0.423			NA											4	103					0	0	0.000248	0	0
PCLO	27445	broad.mit.edu	37	7	82544135	82544136	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:82544135_82544136CC>AA	uc003uhx.2	-	7	13455_13456	c.13166_13167GG>TT	c.(13165-13167)AGG>ATT	p.R4389I	PCLO_uc003uhv.2_Missense_Mutation_p.R4389I|PCLO_uc010lec.2_Missense_Mutation_p.R1354I	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4320					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAAACTGATCCCTGGTGTCTGC	0.525			NA											9	29					0	0	0.004672	0	0
PCLO	27445	broad.mit.edu	37	7	82585859	82585859	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:82585859C>G	uc003uhx.2	-	5	4699	c.4410G>C	c.(4408-4410)GAG>GAC	p.E1470D	PCLO_uc003uhv.2_Missense_Mutation_p.E1470D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1401					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTCTTGACTCTCTTTGATCT	0.368			NA											11	100					0	0	0.001368	0	0
SAMD9	54809	broad.mit.edu	37	7	92731170	92731170	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:92731170T>A	uc003umf.2	-	3	4497	c.4241A>T	c.(4240-4242)CAG>CTG	p.Q1414L	SAMD9_uc003umg.2_Missense_Mutation_p.Q1414L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1414						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTCTCGAAGCTGATCTTTTAG	0.378			NA											26	102					0	0	0.005443	0	0
SAMD9	54809	broad.mit.edu	37	7	92734837	92734837	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:92734837C>G	uc003umf.2	-	3	830	c.574G>C	c.(574-576)GAT>CAT	p.D192H	SAMD9_uc003umg.2_Missense_Mutation_p.D192H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	192						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGTATCGGATCAATGAGATTG	0.393			NA											21	87					0	0	0.001523	0	0
COL1A2	1278	broad.mit.edu	37	7	94049556	94049556	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:94049556G>T	uc003ung.1	+	35	2562	c.2091G>T	c.(2089-2091)GGG>GGT	p.G697G	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	697			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GCGAAGCTGGGGctgctggtc	0.398			NA								HNSCC(75;0.22)			33	86					1.414e-09	2.20814e-09	0.003755	1	0
TAC1	6863	broad.mit.edu	37	7	97361970	97361970	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:97361970C>A	uc003uop.3	+	2	292	c.46C>A	c.(46-48)CAG>AAG	p.Q16K	TAC1_uc003uoq.3_Missense_Mutation_p.Q16K|TAC1_uc003uor.3_Missense_Mutation_p.Q16K|TAC1_uc003uos.3_Missense_Mutation_p.Q16K	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	16					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	TGTCTCCACTCAGCTGTTTGC	0.488			NA											32	107					2.85442e-18	5.3841e-18	0.002096	1	0
LMTK2	22853	broad.mit.edu	37	7	97780744	97780744	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:97780744A>T	uc003upd.1	+	4	720	c.427A>T	c.(427-429)ATT>TTT	p.I143F		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	143	ATP (By similarity).|Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CATACAGGAAATTGGAAATGG	0.338			NA											17	40					0	0	0.007413	0	0
TRRAP	8295	broad.mit.edu	37	7	98546278	98546278	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:98546278G>A	uc003upp.2	+	34	4946	c.4737G>A	c.(4735-4737)CTG>CTA	p.L1579L	TRRAP_uc011kis.1_Silent_p.L1561L|TRRAP_uc003upr.2_Silent_p.L1278L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1579					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAGCCACACTGAACGATCCCC	0.527			NA											8	56					0	0	0.004482	0	0
ATP5J2	9551	broad.mit.edu	37	7	99063748	99063748	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:99063748T>A	uc003uqm.2	-	1	61	c.17A>T	c.(16-18)GAG>GTG	p.E6V	PTCD1_uc011kiw.1_Intron|ATP5J2_uc003uql.2_Intron|ATP5J2_uc003uqn.2_Intron|ATP5J2_uc003uqo.2_Missense_Mutation_p.E6V	NM_004889	NP_004880	P56134	ATPK_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	6					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)				ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGCCGGACACTCACCAACTGA	0.647			NA											9	45					0	0	0.004482	0	0
AP4M1	9179	broad.mit.edu	37	7	99701314	99701314	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:99701314A>T	uc003utb.3	+	6	750	c.542A>T	c.(541-543)CAG>CTG	p.Q181L	MCM7_uc003usv.1_5'Flank|MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Missense_Mutation_p.Q135L|AP4M1_uc010lgl.1_Missense_Mutation_p.Q181L|AP4M1_uc003utc.3_Missense_Mutation_p.Q188L|AP4M1_uc010lgm.2_Missense_Mutation_p.Q53L|AP4M1_uc003utd.2_Missense_Mutation_p.Q181L|AP4M1_uc011kjh.1_Missense_Mutation_p.Q133L|AP4M1_uc003ute.3_5'UTR|AP4M1_uc003utf.3_Missense_Mutation_p.Q53L	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	181	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGCTCTGACCAGGTGAGGGAA	0.483	Pancreas(174;1182 2812 29595 49511)		NA											39	110					0	0	0.004289	0	0
C7orf51	222950	broad.mit.edu	37	7	100091411	100091411	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:100091411G>T	uc003uvd.1	+	7	2570	c.2411G>T	c.(2410-2412)TGC>TTC	p.C804F	C7orf51_uc003uve.1_Missense_Mutation_p.C587F	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	804										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGAGGCCTCTGCAAGCAGGAG	0.731			NA											5	23					0.000602214	0.000715729	0.000602	1	0
ZAN	7455	broad.mit.edu	37	7	100349983	100349983	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:100349983C>A	uc003uwj.2	+	14	2420	c.2255C>A	c.(2254-2256)CCC>CAC	p.P752H	ZAN_uc003uwk.2_Missense_Mutation_p.P752H|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	752	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACAGAAAAACCCACCATCTCC	0.522			NA											19	65					8.00594e-06	1.06985e-05	0.007413	1	0
SLC12A9	56996	broad.mit.edu	37	7	100458871	100458871	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:100458871G>T	uc003uwp.2	+	10	1472	c.1330G>T	c.(1330-1332)GCC>TCC	p.A444S	SLC12A9_uc003uwq.2_Missense_Mutation_p.A355S|SLC12A9_uc011kki.1_5'UTR|SLC12A9_uc003uwr.2_Missense_Mutation_p.A180S|SLC12A9_uc003uws.2_5'UTR|SLC12A9_uc003uwt.2_Missense_Mutation_p.A180S|SLC12A9_uc003uwv.2_5'UTR	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	444	Cytoplasmic (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTGGGCCTCGGCCCCCAACTT	0.642			NA											16	89					1.15088e-07	1.6584e-07	0.004007	1	0
MUC17	140453	broad.mit.edu	37	7	100685526	100685526	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:100685526C>G	uc003uxp.1	+	3	10882	c.10829C>G	c.(10828-10830)TCT>TGT	p.S3610C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3610	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|58.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGACCACTTCTACTCAGAGC	0.468			NA											6	173					0	0	0.001984	0	0
ORAI2	80228	broad.mit.edu	37	7	102079459	102079459	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:102079459C>G	uc010lhz.1	+	3	291	c.56C>G	c.(55-57)CCC>CGC	p.P19R	ORAI2_uc003uzj.2_Missense_Mutation_p.P19R|ORAI2_uc003uzk.2_Missense_Mutation_p.P19R|ORAI2_uc011kks.1_Intron	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	19						integral to membrane	protein binding			ovary(1)|kidney(1)	2						TGCCCTGAGCCCGGCCATAAG	0.617			NA											22	77					0	0	0.004656	0	0
SLC26A5	375611	broad.mit.edu	37	7	103061306	103061306	+	Silent	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:103061306T>A	uc003vbz.2	-	4	407	c.171A>T	c.(169-171)ATA>ATT	p.I57I	SLC26A5_uc003vbt.1_Silent_p.I57I|SLC26A5_uc003vbu.1_Silent_p.I57I|SLC26A5_uc003vbv.1_Silent_p.I57I|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.I57I|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	57	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TGATATTTCTTATTTTTTTAG	0.358			NA											16	53					0	0	0.004007	0	0
MLL5	55904	broad.mit.edu	37	7	104747098	104747098	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:104747098C>G	uc003vcm.2	+	20	3260	c.2726C>G	c.(2725-2727)TCT>TGT	p.S909C	MLL5_uc010ljc.2_Missense_Mutation_p.S909C|MLL5_uc010lje.1_Intron|MLL5_uc010ljf.1_5'Flank|MLL5_uc010ljg.2_5'Flank|MLL5_uc010ljh.1_5'Flank	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	909					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ATGGACCCATCTTTTGCCACG	0.433			NA											7	166					0	0	0.001984	0	0
PUS7	54517	broad.mit.edu	37	7	105146454	105146454	+	Missense_Mutation	SNP	C	C	A	rs141658791	by1000genomes	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:105146454C>A	uc003vcx.2	-	4	752	c.533G>T	c.(532-534)CGA>CTA	p.R178L	PUS7_uc010lji.2_Missense_Mutation_p.R178L|PUS7_uc003vcy.2_Missense_Mutation_p.R178L|PUS7_uc003vcz.1_Missense_Mutation_p.R178L	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	178					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						CTCTTCCAATCGCTGCTTTTC	0.338	Colon(138;2387 3051 17860)		NA											38	154					1.96642e-18	3.71435e-18	0.006999	1	0
CBLL1	79872	broad.mit.edu	37	7	107399464	107399464	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:107399464G>C	uc003veq.2	+	6	1647	c.1317G>C	c.(1315-1317)CTG>CTC	p.L439L	CBLL1_uc011kme.1_Silent_p.L318L|CBLL1_uc011kmf.1_Silent_p.L438L	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	439	Pro-rich.			L -> P (in Ref. 1; BAB15544).	cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						AAGGAACTCTGAGCCCTCCAT	0.537			NA											6	101					0	0	0.001168	0	0
LAMB4	22798	broad.mit.edu	37	7	107688526	107688526	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:107688526C>A	uc010ljo.1	-	28	4237	c.4153G>T	c.(4153-4155)GTG>TTG	p.V1385L	LAMB4_uc003vey.2_Missense_Mutation_p.V1385L|LAMB4_uc010ljp.1_Missense_Mutation_p.V354L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1385	Domain alpha.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GGCAAGGGCACACATGGCACA	0.502			NA											26	130					1.17739e-12	2.00665e-12	0.005443	1	0
NRCAM	4897	broad.mit.edu	37	7	107823167	107823167	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:107823167A>T	uc003vfb.2	-	23	2973	c.2502T>A	c.(2500-2502)GCT>GCA	p.A834A	NRCAM_uc003vfc.2_Silent_p.A818A|NRCAM_uc011kmk.1_Silent_p.A829A|NRCAM_uc003vfd.2_Silent_p.A810A|NRCAM_uc003vfe.2_Silent_p.A810A	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	834	Fibronectin type-III 2.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CCATGACTACAGCTGGCTCGG	0.483			NA											10	46					0	0	0.008291	0	0
LRRN3	54674	broad.mit.edu	37	7	110763749	110763750	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:110763749_110763750CC>AA	uc003vft.3	+	4	1967_1968	c.921_922CC>AA	c.(919-924)AACCTG>AAAATG	p.307_308NL>KM	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.307_308NL>KM|LRRN3_uc003vfs.3_Missense_Mutation_p.307_308NL>KM	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	307_308	Extracellular (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CTGTGGATAACCTGCCAGATTT	0.396			NA											8	69					0	0	0.004672	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519495	113519495	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:113519495C>A	uc010ljy.1	-	4	1683	c.1652G>T	c.(1651-1653)AGT>ATT	p.S551I		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	551					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						CCCTGCCACACTTATTTTAGG	0.413			NA											14	63					3.35478e-16	6.13823e-16	0.003163	1	0
KCND2	3751	broad.mit.edu	37	7	119915331	119915331	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:119915331C>T	uc003vjj.1	+	1	1610	c.645C>T	c.(643-645)CAC>CAT	p.H215H		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	215					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCCCAGGTCACATTAAAGAAC	0.537			NA											6	36					0	0	0.001168	0	0
C7orf58	79974	broad.mit.edu	37	7	120655759	120655759	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:120655759G>A	uc003vjq.3	+	3	737	c.290G>A	c.(289-291)CGA>CAA	p.R97Q	C7orf58_uc003vjr.1_Missense_Mutation_p.R97Q|C7orf58_uc003vjs.3_Missense_Mutation_p.R97Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	97						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AGCCATGGCCGAAGGGCCATA	0.428			NA											5	63					0	0	0.000602	0	0
CADPS2	93664	broad.mit.edu	37	7	121985728	121985728	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:121985728C>T	uc010lkp.2	-	27	3675	c.3512G>A	c.(3511-3513)GGA>GAA	p.G1171E	CADPS2_uc011knx.1_Missense_Mutation_p.G546E|CADPS2_uc003vkg.3_Missense_Mutation_p.G825E|CADPS2_uc010lkq.2_Missense_Mutation_p.G1130E	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1171					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CAGATCCATTCCTGGTTTCTG	0.318			NA											11	85					0	0	0.008291	0	0
ASB15	142685	broad.mit.edu	37	7	123257734	123257734	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:123257734G>T	uc003vku.1	+	7	686	c.394G>T	c.(394-396)GAA>TAA	p.E132*	ASB15_uc003vkv.1_Nonsense_Mutation_p.E132*|ASB15_uc003vkw.1_Nonsense_Mutation_p.E132*	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	132	ANK 1.				intracellular signal transduction					skin(2)|lung(1)	3						AACTTTATTAGAAAAGGGAGT	0.388			NA											10	45					2.80697e-09	4.35308e-09	0.000978	1	0
GPR37	2861	broad.mit.edu	37	7	124404327	124404327	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:124404327G>A	uc003vli.2	-	1	1355	c.704C>T	c.(703-705)CCC>CTC	p.P235L		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	235	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TCCCCGGCGGGGACCCCCAGG	0.632			NA											6	41					0	0	0.001168	0	0
GRM8	2918	broad.mit.edu	37	7	126883160	126883160	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:126883160G>A	uc003vlr.2	-	1	410	c.99C>T	c.(97-99)AGC>AGT	p.S33S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.S33S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	33					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CATACTCCTGGCTGTGAGTTC	0.532			NA								HNSCC(24;0.065)			21	79					0	0	0.001882	0	0
PAX4	5078	broad.mit.edu	37	7	127255572	127255572	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:127255572C>A	uc010lld.1	-	1	209	c.3G>T	c.(1-3)ATG>ATT	p.M1I	PAX4_uc003vmf.2_5'UTR|PAX4_uc003vmg.1_Missense_Mutation_p.M1I|PAX4_uc003vmh.2_5'UTR	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	9	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAAGCTGGTTCATGCTGCTGA	0.637	Ovarian(113;737 1605 7858 27720 34092)		NA											16	45					2.35188e-11	3.89948e-11	0.006122	1	0
IMPDH1	3614	broad.mit.edu	37	7	128034338	128034338	+	Missense_Mutation	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:128034338A>C	uc011kol.1	-	13	1623	c.1517T>G	c.(1516-1518)CTG>CGG	p.L506R	IMPDH1_uc011kom.1_Missense_Mutation_p.L501R|IMPDH1_uc003vmt.2_Missense_Mutation_p.L481R|IMPDH1_uc003vmu.2_Missense_Mutation_p.L591R|IMPDH1_uc003vmw.2_Missense_Mutation_p.L581R|IMPDH1_uc011kon.1_Missense_Mutation_p.L558R|IMPDH1_uc003vmv.2_Missense_Mutation_p.L555R|IMPDH1_uc003vmx.2_Missense_Mutation_p.L514R|IMPDH1_uc003vmy.2_Missense_Mutation_p.L522R|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	506					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	TTACGAGTGCAGGCCATGGAC	0.592			NA											4	28					0	0	0.000602	0	0
CALU	813	broad.mit.edu	37	7	128398927	128398927	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:128398927G>T	uc003vns.2	+	4	570	c.418G>T	c.(418-420)GAT>TAT	p.D140Y	CALU_uc003vnq.2_Missense_Mutation_p.D140Y|CALU_uc003vnr.2_Missense_Mutation_p.D140Y	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	140					platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						TTTTCTAGATGATCCAGATCC	0.363			NA											25	83					9.86323e-18	1.84489e-17	0.003954	1	0
TNPO3	23534	broad.mit.edu	37	7	128612603	128612604	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:128612603_128612604CC>AA	uc003vol.1	-	19	2680_2681	c.2306_2307GG>TT	c.(2305-2307)CGG>CTT	p.R769L	TNPO3_uc010llx.1_Missense_Mutation_p.R180L|TNPO3_uc003vom.1_Missense_Mutation_p.R703L|TNPO3_uc010lly.1_Missense_Mutation_p.R803L|TNPO3_uc010llz.1_Missense_Mutation_p.R705L	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	769					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						CCACTTGGCTCCGCAGCAAGGT	0.48	Pancreas(147;583 2585 39696 52331)		NA											7	36					0	0	0.004672	0	0
FAM40B	57464	broad.mit.edu	37	7	129096289	129096289	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:129096289G>T	uc011koy.1	+	9	884	c.844G>T	c.(844-846)GGT>TGT	p.G282C	FAM40B_uc003vow.2_Missense_Mutation_p.G282C|FAM40B_uc011koz.1_5'Flank	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	282											0						GTTTACCCTCGGTGGATTTGA	0.512			NA											4	70					1.23904e-05	1.62503e-05	0.000602	1	0
PLXNA4	91584	broad.mit.edu	37	7	132192749	132192749	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:132192749G>T	uc003vra.3	-	2	933	c.704C>A	c.(703-705)ACC>AAC	p.T235N	PLXNA4_uc003vrc.2_Missense_Mutation_p.T235N|PLXNA4_uc003vrb.2_Missense_Mutation_p.T235N	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	235	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGGGATGATGGTGAAGGTGTC	0.488			NA											22	58					2.52088e-20	4.85034e-20	0.00278	1	0
AKR1B1	231	broad.mit.edu	37	7	134136493	134136493	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:134136493G>T	uc003vrp.1	-	2	153	c.79C>A	c.(79-81)CAG>AAG	p.Q27K	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	27					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	TCAGTCACCTGCCCTGGAGGG	0.597			NA											5	21					0.000602214	0.000715729	0.000602	1	0
SVOPL	136306	broad.mit.edu	37	7	138329521	138329521	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:138329521G>T	uc011kqh.1	-	8	730	c.730C>A	c.(730-732)CGC>AGC	p.R244S	SVOPL_uc003vue.2_Missense_Mutation_p.R92S	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	244						integral to membrane	transmembrane transporter activity				0						TTGGCAACGCGCTCCAGAGTG	0.587			NA											16	73					2.23348e-06	3.05455e-06	0.004007	1	0
PARP12	64761	broad.mit.edu	37	7	139756937	139756937	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:139756937T>A	uc003vvl.1	-	3	1353	c.479A>T	c.(478-480)AAC>ATC	p.N160I	PARP12_uc003vvk.1_5'UTR|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	160	C3H1-type 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					ATCTCCTTTGTTGTAATGTTG	0.493			NA											33	97					0	0	0.002096	0	0
PRSS1	5644	broad.mit.edu	37	7	142459706	142459706	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:142459706C>G	uc003wak.2	+	3	299	c.282C>G	c.(280-282)ATC>ATG	p.I94M	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.I34M	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	94	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CCAAGATCATCCGCCACCCCC	0.542			NA							Hereditary_Pancreatitis				32	110					0	0	0.003271	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175208	143175208	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:143175208C>A	uc003wdc.1	+	1	243	c.243C>A	c.(241-243)GGC>GGA	p.G81G	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	81	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					GGGGTCTCGGCCGACAGTTCT	0.537			NA											27	91					1.17739e-12	2.00665e-12	0.005443	1	0
OR2A7	401427	broad.mit.edu	37	7	143973470	143973470	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:143973470C>A	uc003wef.2	-	4	423	c.272G>T	c.(271-273)AGC>ATC	p.S91I	OR2A9P_uc003wec.1_Intron			Q96R45	OR2A7_HUMAN	SubName: Full=LOC728377 protein; Flags: Fragment;	Error:Variant_position_missing_in_Q96R45_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					AATCTTCTGGCTCAGGTAGAT	0.542			NA											8	202					3.07112e-06	4.16617e-06	0.000978	1	0
OR2A7	401427	broad.mit.edu	37	7	143973472	143973472	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:143973472C>A	uc003wef.2	-	4	421	c.270G>T	c.(268-270)CTG>CTT	p.L90L	OR2A9P_uc003wec.1_Intron			Q96R45	OR2A7_HUMAN	SubName: Full=LOC728377 protein; Flags: Fragment;	Error:Variant_position_missing_in_Q96R45_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					TCTTCTGGCTCAGGTAGATTA	0.537			NA											10	205					5.50884e-06	7.37624e-06	0.001368	1	0
TPK1	27010	broad.mit.edu	37	7	144245632	144245632	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:144245632C>A	uc003weq.2	-	8	668	c.565G>T	c.(565-567)GGA>TGA	p.G189*	TPK1_uc003weo.2_Nonsense_Mutation_p.G135*|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Nonsense_Mutation_p.G140*|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	189					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	CAAGGCTGTCCAACAGGAATA	0.403	Ovarian(45;88 1034 2073 5829 28455)		NA											15	88					2.35188e-11	3.89948e-11	0.006122	1	0
CUL1	8454	broad.mit.edu	37	7	148427288	148427288	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:148427288G>T	uc010lpg.2	+	2	600	c.74G>T	c.(73-75)AGA>ATA	p.R25I	CUL1_uc003wey.2_Missense_Mutation_p.R25I|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	25					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GACGACCTCAGAGCCGGCATC	0.567			NA											13	67					6.81908e-15	1.21944e-14	0.00245	1	0
CUL1	8454	broad.mit.edu	37	7	148486887	148486887	+	Missense_Mutation	SNP	A	A	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:148486887A>C	uc010lpg.2	+	15	2169	c.1643A>C	c.(1642-1644)CAG>CCG	p.Q548P	CUL1_uc003wey.2_Missense_Mutation_p.Q548P|CUL1_uc003wez.2_Missense_Mutation_p.Q438P|CUL1_uc003wfa.2_Missense_Mutation_p.Q209P	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	548					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGGCCCTTCCAGCAGTCTTGT	0.517			NA											41	130					0	0	0.00361	0	0
MLL3	58508	broad.mit.edu	37	7	151871221	151871221	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:151871221C>G	uc003wla.2	-	39	9588	c.9369G>C	c.(9367-9369)ATG>ATC	p.M3123I	MLL3_uc003wkz.2_Missense_Mutation_p.M2184I|MLL3_uc003wky.2_Missense_Mutation_p.M632I	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3123	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCTACCTGCTCATCACCATTG	0.393	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								3	74					0	0	0.004672	0	0
MLL3	58508	broad.mit.edu	37	7	151879291	151879291	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:151879291C>A	uc003wla.2	-	36	5873	c.5654G>T	c.(5653-5655)GGG>GTG	p.G1885V	MLL3_uc003wkz.2_Missense_Mutation_p.G946V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1885	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GTTAGAGGACCCAGGTGAAAA	0.532	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								21	95					2.37509e-13	4.13716e-13	0.001523	1	0
VIPR2	7434	broad.mit.edu	37	7	158835763	158835763	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:158835763G>T	uc003woh.2	-	6	746	c.560C>A	c.(559-561)TCT>TAT	p.S187Y	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	187	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane		p.S187Y(1)		lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CAACGTGCCAGAGCTGGAGTA	0.557	Pancreas(154;1876 1931 2329 17914 20079)		NA											6	31					1.26484e-09	1.98445e-09	0.00308	1	0
RP1L1	94137	broad.mit.edu	37	8	10468763	10468763	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:10468763G>T	uc003wtc.2	-	4	3074	c.2845C>A	c.(2845-2847)CCC>ACC	p.P949T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	949					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GACGAGCGGGGCAGAGAGCTG	0.642			NA											7	43					5.4927e-09	8.40171e-09	0.004482	1	0
MSR1	4481	broad.mit.edu	37	8	16032707	16032707	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:16032707C>A	uc003wwz.2	-	3	404	c.206G>T	c.(205-207)GGA>GTA	p.G69V	MSR1_uc010lsu.2_Missense_Mutation_p.G87V|MSR1_uc003wxa.2_Missense_Mutation_p.G69V|MSR1_uc003wxb.2_Missense_Mutation_p.G69V|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	69	Helical; Signal-anchor for type II membrane protein; (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TGCCACTATTCCAATGAGAGG	0.418			NA											8	27					1.12685e-05	1.48953e-05	0.004482	1	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729733	37729733	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:37729733C>A	uc003xkm.1	-	4	2631	c.2587G>T	c.(2587-2589)GAA>TAA	p.E863*	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Nonsense_Mutation_p.E192*|RAB11FIP1_uc003xko.1_Nonsense_Mutation_p.E192*|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	863					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GATTCCCTTTCTGAGTCCTCT	0.627			NA											15	66					2.32078e-09	3.60742e-09	0.003163	1	0
IKBKB	3551	broad.mit.edu	37	8	42179669	42179669	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:42179669C>G	uc003xow.1	+	18	2013	c.1836C>G	c.(1834-1836)CTC>CTG	p.L612L	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.L389L|IKBKB_uc003xox.1_Silent_p.L333L|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.L610L|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.L553L	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	612					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATACGCAGCTCAGGTATGAGC	0.547			NA											7	52					0	0	0.001984	0	0
CHRNB3	1142	broad.mit.edu	37	8	42591710	42591711	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:42591710_42591711GG>TT	uc003xpi.1	+	6	1454_1455	c.1326_1327GG>TT	c.(1324-1329)TCGGTT>TCTTTT	p.V443F		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	443	Helical; (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TAACAGGCTCGGTTCTGATTTT	0.396			NA											37	111					0	0	0.004672	0	0
ST18	9705	broad.mit.edu	37	8	53084452	53084452	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:53084452G>T	uc003xqz.2	-	5	1125	c.969C>A	c.(967-969)ACC>ACA	p.T323T	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.T288T|ST18_uc011lds.1_Silent_p.T228T|ST18_uc003xra.2_Silent_p.T323T|ST18_uc003xrb.2_Silent_p.T323T	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	323						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GCTCTTTGTAGGTGTTATGGA	0.483			NA											19	66					2.4624e-09	3.82312e-09	0.001216	1	0
RGS20	8601	broad.mit.edu	37	8	54764607	54764607	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:54764607G>T	uc003xrp.2	+	1	240	c.148G>T	c.(148-150)GCT>TCT	p.A50S	RGS20_uc003xrq.2_Missense_Mutation_p.A50S|RGS20_uc010lye.2_Silent_p.G6G|RGS20_uc010lyf.2_Silent_p.G6G	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	50					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			AGACCTCAGGGCTGTTCCTGA	0.433			NA											15	28					6.72482e-11	1.09472e-10	0.003163	1	0
NSMAF	8439	broad.mit.edu	37	8	59515919	59515919	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:59515919C>T	uc003xtt.2	-	13	1109	c.895G>A	c.(895-897)GAG>AAG	p.E299K	NSMAF_uc011lee.1_Missense_Mutation_p.E330K|NSMAF_uc003xtu.2_Missense_Mutation_p.E299K	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	299	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				ATGTAGCTCTCAGCAGTGTGC	0.557			NA											15	43					0	0	0.00245	0	0
NCOA2	10499	broad.mit.edu	37	8	71068584	71068584	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:71068584C>A	uc003xyn.1	-	11	2178	c.2016G>T	c.(2014-2016)TTG>TTT	p.L672F		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	672					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CAGAACCAGGCAAGCTACCTG	0.517			NA	T	RUNXBP2	AML								62	71					1.72039e-30	3.41787e-30	0.00361	1	0
KCNB2	9312	broad.mit.edu	37	8	73480145	73480145	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:73480145C>A	uc003xzb.2	+	2	764	c.176C>A	c.(175-177)ACG>AAG	p.T59K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	59	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTGCCCAGGACGCGCCTGGGG	0.537			NA											30	82					5.6714e-07	7.96725e-07	0.002096	1	0
STAU2	27067	broad.mit.edu	37	8	74515961	74515961	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:74515961C>A	uc003xzm.2	-	10	1265	c.1029G>T	c.(1027-1029)CAG>CAT	p.Q343H	STAU2_uc011lfg.1_Missense_Mutation_p.Q171H|STAU2_uc003xzn.2_Missense_Mutation_p.Q311H|STAU2_uc011lfh.1_Missense_Mutation_p.Q239H|STAU2_uc003xzo.2_Missense_Mutation_p.Q343H|STAU2_uc003xzp.2_Missense_Mutation_p.Q311H|STAU2_uc011lfi.1_Missense_Mutation_p.Q305H|STAU2_uc003xzq.2_Missense_Mutation_p.Q123H|STAU2_uc010lzk.2_Missense_Mutation_p.Q311H|STAU2_uc010lzl.1_Missense_Mutation_p.Q171H	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	343	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TTAGAAATACCTGCATCACAA	0.423			NA											17	27					9.7654e-05	0.000121435	0.007413	1	0
Unknown	0	broad.mit.edu	37	8	86567355	86567355	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:86567355G>T	uc003ydl.1	-	1	551	c.464C>A	c.(463-465)ACG>AAG	p.T155K		NM_172239	NP_758439			exonuclease GOR												NA						CAGGCCATGCGTGGTGTAGCA	0.567			NA											13	138					0.00010058	0.000124382	0.001368	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885094	88885094	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:88885094G>T	uc003ydz.2	-	1	1203	c.1106C>A	c.(1105-1107)TCT>TAT	p.S369Y		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	369										ovary(1)	1						GAGGCGAGAAGAGAAGGCCAC	0.587			NA											13	53					1.36491e-13	2.38371e-13	0.001855	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885822	88885822	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:88885822C>T	uc003ydz.2	-	1	475	c.378G>A	c.(376-378)AAG>AAA	p.K126K		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	126										ovary(1)	1						TAGAATTCACCTTCCGATTAG	0.562			NA											25	61					0	0	0.003954	0	0
NECAB1	64168	broad.mit.edu	37	8	91929850	91929850	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:91929850A>G	uc011lgg.1	+	6	682	c.488A>G	c.(487-489)CAA>CGA	p.Q163R		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	163	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CAAACCCGTCAAGAAAGGCAA	0.378			NA											3	56					0	0	0.004672	0	0
CDH17	1015	broad.mit.edu	37	8	95183141	95183141	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:95183141T>C	uc003ygh.2	-	8	981	c.856A>G	c.(856-858)ATT>GTT	p.I286V	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.I286V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	286	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCCTGGTCAATTGAAAATGGG	0.463			NA											25	104					0	0	0.005443	0	0
ESRP1	54845	broad.mit.edu	37	8	95690472	95690472	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:95690472G>C	uc003ygq.3	+	13	1876	c.1693G>C	c.(1693-1695)GTT>CTT	p.V565L	ESRP1_uc003ygr.3_Missense_Mutation_p.V561L|ESRP1_uc003ygs.3_Missense_Mutation_p.V561L|ESRP1_uc003ygt.3_Missense_Mutation_p.V565L|ESRP1_uc003ygu.3_Missense_Mutation_p.V561L|ESRP1_uc003ygv.2_Missense_Mutation_p.V405L|ESRP1_uc003ygw.2_Missense_Mutation_p.V405L	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	565					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TCCTGCTGCAGTTATTCCTAC	0.498			NA											21	40					0	0	0.002299	0	0
DPY19L4	286148	broad.mit.edu	37	8	95800281	95800281	+	Splice_Site	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:95800281G>T	uc003ygx.2	+	18	2131	c.2007_splice	c.e18+1	p.H669_splice		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4							integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					AAATGGCCACGTAAGTAACCA	0.284			NA											7	51					5.18039e-06	6.99223e-06	0.00308	1	0
PGCP	10404	broad.mit.edu	37	8	97978195	97978195	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:97978195G>T	uc003yhw.2	+	5	1048	c.882G>T	c.(880-882)TGG>TGT	p.W294C	PGCP_uc010mbe.2_Missense_Mutation_p.W294C	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	294					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TGGACAGCTGGGATGTTGGGC	0.358			NA											8	48					0.000157383	0.000191976	0.00308	1	0
MATN2	4147	broad.mit.edu	37	8	98943360	98943360	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:98943360G>T	uc003yic.2	+	3	553	c.322G>T	c.(322-324)GAG>TAG	p.E108*	MATN2_uc003yib.1_Nonsense_Mutation_p.E108*|MATN2_uc010mbh.1_Nonsense_Mutation_p.E108*|MATN2_uc003yid.2_Nonsense_Mutation_p.E108*|MATN2_uc003yie.1_Nonsense_Mutation_p.E108*|MATN2_uc010mbi.1_5'UTR	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	108	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGTCAAGAATGAGTTCTCCCT	0.542			NA											7	41					0.00198382	0.00231877	0.001984	1	0
RGS22	26166	broad.mit.edu	37	8	101065078	101065078	+	Silent	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:101065078G>C	uc003yjb.1	-	10	1836	c.1641C>G	c.(1639-1641)CTC>CTG	p.L547L	RGS22_uc003yja.1_Silent_p.L366L|RGS22_uc003yjc.1_Silent_p.L535L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	547					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTAATGGCAAGAGGGTTGCCA	0.423			NA											4	165					0	0	0.000602	0	0
UBR5	51366	broad.mit.edu	37	8	103277397	103277397	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:103277397C>G	uc003ykr.1	-	53	7565	c.7532G>C	c.(7531-7533)AGA>ACA	p.R2511T	UBR5_uc003yks.1_Missense_Mutation_p.R2510T|UBR5_uc003ykq.2_Missense_Mutation_p.R22T	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2511	HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATAAAATCCTCTTTTCCCAGG	0.403	Ovarian(131;96 1741 5634 7352 27489)		NA											4	99					0	0	0.000248	0	0
RIMS2	9699	broad.mit.edu	37	8	104948909	104948909	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:104948909C>A	uc003yls.2	+	11	2081	c.1840C>A	c.(1840-1842)CAA>AAA	p.Q614K	RIMS2_uc003ylp.2_Missense_Mutation_p.Q836K|RIMS2_uc003ylw.2_Missense_Mutation_p.Q628K|RIMS2_uc003ylq.2_Missense_Mutation_p.Q628K|RIMS2_uc003ylr.2_Missense_Mutation_p.Q675K|RIMS2_uc003ylt.2_Missense_Mutation_p.Q221K	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	898	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCTTTGGGATCAAGCTCGTGT	0.373			NA								HNSCC(12;0.0054)			22	69					1.96895e-08	2.93811e-08	0.00278	1	0
TM7SF4	81501	broad.mit.edu	37	8	105361740	105361740	+	Silent	SNP	C	C	A	rs144377739	byFrequency	TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:105361740C>A	uc003ylx.1	+	2	1009	c.960C>A	c.(958-960)CTC>CTA	p.L320L		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	320					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGTATCGGCTCATTTTCTCAG	0.458			NA											73	176					1.54081e-58	3.13531e-58	0.00361	1	0
ZFPM2	23414	broad.mit.edu	37	8	106813863	106813863	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:106813863C>A	uc003ymd.2	+	8	1576	c.1553C>A	c.(1552-1554)GCT>GAT	p.A518D	ZFPM2_uc011lhs.1_Missense_Mutation_p.A249D	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	518					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGATCTTAGCTAAGATGTCT	0.502			NA											60	132					5.47352e-35	1.09716e-34	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113529330	113529330	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:113529330C>G	uc003ynu.2	-	28	4848	c.4689G>C	c.(4687-4689)GAG>GAC	p.E1563D	CSMD3_uc003yns.2_Missense_Mutation_p.E835D|CSMD3_uc003ynt.2_Missense_Mutation_p.E1523D|CSMD3_uc011lhx.1_Missense_Mutation_p.E1459D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1563	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATTCTTTCCTCTCCTTGAA	0.433			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	70					0	0	0.004656	0	0
CSMD3	114788	broad.mit.edu	37	8	113694742	113694742	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:113694742C>A	uc003ynu.2	-	16	2765	c.2606G>T	c.(2605-2607)GGA>GTA	p.G869V	CSMD3_uc003yns.2_Missense_Mutation_p.G141V|CSMD3_uc003ynt.2_Missense_Mutation_p.G829V|CSMD3_uc011lhx.1_Missense_Mutation_p.G765V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	869	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTTTCTGTTCCCTGGGTTTT	0.373			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	63					5.35267e-07	7.53525e-07	0.007413	1	0
CSMD3	114788	broad.mit.edu	37	8	113694744	113694744	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:113694744C>A	uc003ynu.2	-	16	2763	c.2604G>T	c.(2602-2604)CAG>CAT	p.Q868H	CSMD3_uc003yns.2_Missense_Mutation_p.Q140H|CSMD3_uc003ynt.2_Missense_Mutation_p.Q828H|CSMD3_uc011lhx.1_Missense_Mutation_p.Q764H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	868	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTCTGTTCCCTGGGTTTTAA	0.378			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	67					1.99824e-07	2.86407e-07	0.00499	1	0
TRPS1	7227	broad.mit.edu	37	8	116631637	116631637	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:116631637G>C	uc003ynz.2	-	2	1108	c.649C>G	c.(649-651)CCA>GCA	p.P217A	TRPS1_uc011lhy.1_Missense_Mutation_p.P221A|TRPS1_uc003yny.2_Missense_Mutation_p.P230A|TRPS1_uc010mcy.2_Missense_Mutation_p.P217A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	217					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGAAGCTCTGGAGACAGAGGT	0.453			NA							Langer-Giedion_syndrome				5	159					0	0	0.000602	0	0
COL14A1	7373	broad.mit.edu	37	8	121357730	121357730	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:121357730G>A	uc003yox.2	+	45	5270	c.5005G>A	c.(5005-5007)GGT>AGT	p.G1669S	COL14A1_uc003yoz.2_Missense_Mutation_p.G634S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1669	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGAGCCCCTGGTGAACAAGG	0.642			NA											8	39					0	0	0.004482	0	0
ATAD2	29028	broad.mit.edu	37	8	124333375	124333375	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:124333375C>T	uc003yqh.3	-	28	4280	c.4172G>A	c.(4171-4173)TGA>TAA	p.*1391*	ATAD2_uc011lii.1_Silent_p.*1182*|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ATGACATCATCATCTGGAACA	0.343			NA											7	84					0	0	0.004482	0	0
FAM91A1	157769	broad.mit.edu	37	8	124801879	124801879	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:124801879A>T	uc003yqv.2	+	15	1366	c.1305A>T	c.(1303-1305)GCA>GCT	p.A435A	FAM91A1_uc011lik.1_Silent_p.A435A|FAM91A1_uc011lil.1_Silent_p.A193A	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	435										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AAGGAGAAGCACAGAGATATT	0.378			NA											18	68					0	0	0.001523	0	0
FER1L6	654463	broad.mit.edu	37	8	124988193	124988193	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:124988193G>T	uc003yqw.2	+	9	945	c.739G>T	c.(739-741)GTG>TTG	p.V247L		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	247	C2 2.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAGATTCTATGTGAGACTCTA	0.468			NA											21	158					1.9806e-07	2.84182e-07	0.002299	1	0
FER1L6	654463	broad.mit.edu	37	8	125074120	125074120	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:125074120C>A	uc003yqw.2	+	25	3381	c.3175C>A	c.(3175-3177)CCG>ACG	p.P1059T	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1059	Cytoplasmic (Potential).|C2 4.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCTTCTGCACCCGCCACTGAG	0.547			NA											17	69					1.02788e-11	1.71911e-11	0.00499	1	0
ASAP1	50807	broad.mit.edu	37	8	131073179	131073179	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:131073179C>A	uc003yta.1	-	27	2866	c.2838G>T	c.(2836-2838)CTG>CTT	p.L946L	ASAP1_uc003ysz.1_Silent_p.L757L|ASAP1_uc011liw.1_Silent_p.L939L	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	946	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GCTTGGGGGCCAGTTCTGTGG	0.577			NA											61	177					9.04393e-38	1.81826e-37	0.00361	1	0
ADCY8	114	broad.mit.edu	37	8	131964203	131964203	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:131964203C>A	uc003ytd.3	-	3	1408	c.1152G>T	c.(1150-1152)CTG>CTT	p.L384L	ADCY8_uc010mds.2_Silent_p.L384L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	384	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGATCATTTCCAGGACAACAA	0.532			NA								HNSCC(32;0.087)			17	65					1.5739e-10	2.54668e-10	0.004007	1	0
ADCY8	114	broad.mit.edu	37	8	132002674	132002674	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:132002674C>A	uc003ytd.3	-	2	1331	c.1075G>T	c.(1075-1077)GCC>TCC	p.A359S	ADCY8_uc010mds.2_Missense_Mutation_p.A359S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	359	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CGCAGCCTGGCCTCCACACAC	0.502			NA								HNSCC(32;0.087)			34	130					4.34311e-12	7.30926e-12	0.003271	1	0
FAM135B	51059	broad.mit.edu	37	8	139155268	139155268	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:139155268T>A	uc003yuy.2	-	16	3796	c.3625A>T	c.(3625-3627)ATA>TTA	p.I1209L	FAM135B_uc003yux.2_Missense_Mutation_p.I1110L|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.I771L|FAM135B_uc003yvb.2_3'UTR	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1209										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATTCGGGATATGGAGAGGTTG	0.403			NA								HNSCC(54;0.14)			14	28					0	0	0.001855	0	0
TSNARE1	203062	broad.mit.edu	37	8	143436085	143436085	+	Missense_Mutation	SNP	T	T	G	rs147546908		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:143436085T>G	uc003ywk.2	-	2	119	c.1A>C	c.(1-3)ATG>CTG	p.M1L	TSNARE1_uc011lju.1_Missense_Mutation_p.M1L|TSNARE1_uc003ywj.2_Missense_Mutation_p.M1L|TSNARE1_uc003ywl.3_Missense_Mutation_p.M1L	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	1					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCGTATGACATCTTCTTACAG	0.572			NA											15	25					0	0	0.00499	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922478	5922478	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:5922478A>G	uc003zjq.3	-	8	3734	c.3518T>C	c.(3517-3519)ATT>ACT	p.I1173T	KIAA2026_uc010mht.2_Missense_Mutation_p.I348T	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1173										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAAAGGTGTAATTGTTTTGTT	0.368			NA											4	91					0	0	0.001168	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18635992	18635992	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:18635992T>C	uc003zne.3	+	6	780	c.653T>C	c.(652-654)GTC>GCC	p.V218A	ADAMTSL1_uc003znb.2_Missense_Mutation_p.V218A|ADAMTSL1_uc003znc.3_Missense_Mutation_p.V218A	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	218						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		ATTCGCCTTGTCTTAAAAGGT	0.353			NA											20	55					0	0	0.001882	0	0
TAF1L	138474	broad.mit.edu	37	9	32633404	32633404	+	Missense_Mutation	SNP	C	C	T	rs145899352		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:32633404C>T	uc003zrg.1	-	1	2264	c.2174G>A	c.(2173-2175)CGG>CAG	p.R725Q	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	725					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCCAGGTTTCCGTTTATAATA	0.423			NA											53	112					0	0	0.00361	0	0
AQP7	364	broad.mit.edu	37	9	33395131	33395131	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:33395131T>A	uc003zst.2	-	3	261	c.89A>T	c.(88-90)CAG>CTG	p.Q30L	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Intron|AQP7_uc010mjs.2_5'Flank|AQP7_uc010mjt.2_5'UTR|AQP7_uc011lnx.1_Missense_Mutation_p.Q30L|AQP7_uc011lny.1_Missense_Mutation_p.Q29L|AQP7_uc003zss.3_5'UTR|AQP7_uc011lnz.1_5'UTR|AQP7_uc011loa.1_5'UTR	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	30	Cytoplasmic (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CATCTTCCTCTGCAGTATTTC	0.577			NA											16	32					0	0	0.003163	0	0
TLN1	7094	broad.mit.edu	37	9	35711289	35711289	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:35711289C>A	uc003zxt.2	-	30	4336	c.3982G>T	c.(3982-3984)GCC>TCC	p.A1328S		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1328	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGGTTAGGGGCAGCAGGGTCC	0.582			NA											4	53					1.23904e-05	1.62503e-05	0.000602	1	0
ALDH1B1	219	broad.mit.edu	37	9	38395746	38395746	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:38395746A>T	uc004aay.2	+	2	113	c.1A>T	c.(1-3)ATG>TTG	p.M1L		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	1					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GAGTGTCAGCATGCTGCGCTT	0.607			NA											6	39					0	0	0.001168	0	0
C9orf71	169693	broad.mit.edu	37	9	71152289	71152289	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:71152289G>A	uc004agt.2	-	2	452	c.399C>T	c.(397-399)TTC>TTT	p.F133F	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	133						integral to membrane					0						TTCCATCCTGGAATTCCAGGC	0.557			NA											4	41					0	0	0.000248	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318740	79318740	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:79318740T>A	uc010mpk.2	-	9	7913	c.7789A>T	c.(7789-7791)ACA>TCA	p.T2597S	PRUNE2_uc004akj.3_Missense_Mutation_p.T50S|PRUNE2_uc010mpl.1_Missense_Mutation_p.T50S	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2597					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGCTGACATGTGTCTGGGAAG	0.428			NA											21	81					0	0	0.001882	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323683	79323683	+	Silent	SNP	C	C	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:79323683C>T	uc010mpk.2	-	8	3631	c.3507G>A	c.(3505-3507)GTG>GTA	p.V1169V		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1169					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CCAGCTGTCTCACTGTAAATC	0.552			NA											34	69					0	0	0.004289	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325100	79325100	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:79325100C>G	uc010mpk.2	-	8	2214	c.2090G>C	c.(2089-2091)AGA>ACA	p.R697T		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	697					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATCTGAGGCTCTCCTATCAAT	0.443			NA											11	23					0	0	0.001368	0	0
VPS13A	23230	broad.mit.edu	37	9	79933397	79933397	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:79933397G>A	uc004akr.2	+	41	5463	c.5203G>A	c.(5203-5205)GCT>ACT	p.A1735T	VPS13A_uc004akp.3_Missense_Mutation_p.A1735T|VPS13A_uc004akq.3_Missense_Mutation_p.A1735T|VPS13A_uc004aks.2_Missense_Mutation_p.A1696T|VPS13A_uc004akt.2_Missense_Mutation_p.A75T|VPS13A_uc010mpo.1_Missense_Mutation_p.A331T	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1735					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						AGTTCTTGAGGCTGGAATTGG	0.383			NA											17	69					0	0	0.00499	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609893	84609893	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:84609893A>T	uc004amn.2	+	4	4555	c.4508A>T	c.(4507-4509)GAG>GTG	p.E1503V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1503						integral to membrane					0						CAGAAAGTTGAGGCATTTAAG	0.502			NA											5	37					0	0	0.000602	0	0
RASEF	158158	broad.mit.edu	37	9	85615413	85615413	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:85615413C>A	uc004amo.1	-	11	1771	c.1510G>T	c.(1510-1512)GGG>TGG	p.G504W		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	504					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CTAACAGACCCTTGGGGCTTC	0.448			NA											18	57					3.32936e-07	4.72157e-07	0.006122	1	0
FAM75C1	441452	broad.mit.edu	37	9	90536463	90536463	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:90536463G>T	uc010mqi.2	+	4	1670	c.1641G>T	c.(1639-1641)GGG>GGT	p.G547G	FAM75C1_uc004apq.3_Silent_p.G530G	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AGGTTCTGGGGGCGACCTCTG	0.512			NA											19	111					0.000132079	0.000163035	0.001216	1	0
ROR2	4920	broad.mit.edu	37	9	94486419	94486419	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:94486419T>C	uc004arj.1	-	9	2556	c.2357A>G	c.(2356-2358)TAC>TGC	p.Y786C	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	786	Cytoplasmic (Potential).|Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GGGCCCCACGTAGCGGGCGTT	0.657			NA											21	39					0	0	0.002299	0	0
COL15A1	1306	broad.mit.edu	37	9	101802814	101802814	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:101802814G>A	uc004azb.1	+	23	2693	c.2487G>A	c.(2485-2487)GGG>GGA	p.G829G		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	829	Triple-helical region 4 (COL4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GGCCGGACGGGTTGCCTGGGC	0.582			NA											16	86					0	0	0.004007	0	0
ERP44	23071	broad.mit.edu	37	9	102769949	102769949	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:102769949G>A	uc004bam.2	-	9	993	c.785C>T	c.(784-786)CCT>CTT	p.P262L	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.P262L	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	262	Interaction with ITPR1 (By similarity).				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						TATGAGAAAAGGCAGTCCTTC	0.348			NA											18	59					0	0	0.006122	0	0
C9orf84	158401	broad.mit.edu	37	9	114484859	114484859	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:114484859T>A	uc004bfr.2	-	13	1904	c.1769A>T	c.(1768-1770)CAG>CTG	p.Q590L	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.Q551L|C9orf84_uc010mug.2_Missense_Mutation_p.Q536L	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	590										ovary(2)	2						TGCTTGGCACTGGCTATCTGC	0.388			NA											8	28					0	0	0.00308	0	0
PRPF4	9128	broad.mit.edu	37	9	116044941	116044941	+	Silent	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:116044941C>G	uc004bgx.2	+	4	461	c.411C>G	c.(409-411)CTC>CTG	p.L137L	PRPF4_uc004bgy.2_Silent_p.L136L	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	137						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						GAAATATCCTCTCAGTTGTCG	0.303			NA											3	38					0	0	0.000602	0	0
TLR4	7099	broad.mit.edu	37	9	120470943	120470943	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:120470943C>A	uc004bjz.2	+	2	487	c.196C>A	c.(196-198)CTG>ATG	p.L66M	TLR4_uc004bka.2_Missense_Mutation_p.L26M|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	66	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTTTAATCCCCTGAGGCATTT	0.443			NA											52	121					4.17463e-26	8.25703e-26	0.00361	1	0
OR1N2	138882	broad.mit.edu	37	9	125316353	125316353	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:125316353T>A	uc011lyx.1	+	1	905	c.905T>A	c.(904-906)CTA>CAA	p.L302Q		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	302	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						ATTCCCACGCTAAACCCATTC	0.393			NA											8	69					0	0	0.006214	0	0
NR6A1	2649	broad.mit.edu	37	9	127300495	127300495	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:127300495C>G	uc004bor.1	-	6	878	c.700G>C	c.(700-702)GGC>CGC	p.G234R	NR6A1_uc004boq.1_Missense_Mutation_p.G229R|NR6A1_uc010mwq.1_Missense_Mutation_p.G230R	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	234	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GGTGAGTGGCCAGAATAGCTA	0.507	Esophageal Squamous(192;272 2884 6208 20560)		NA											9	55					0	0	0.006214	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511506	130511506	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:130511506C>A	uc004bsc.2	-	5	1265	c.1123G>T	c.(1123-1125)GAT>TAT	p.D375Y	SH2D3C_uc010mxo.2_Missense_Mutation_p.D215Y|SH2D3C_uc004bry.2_Missense_Mutation_p.D217Y|SH2D3C_uc004brz.3_Missense_Mutation_p.D21Y|SH2D3C_uc011mak.1_Missense_Mutation_p.D21Y|SH2D3C_uc004bsa.2_Missense_Mutation_p.D218Y|SH2D3C_uc004bsb.2_Missense_Mutation_p.D307Y	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	375					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GGGCAGCCATCGCTGCGGGTG	0.607			NA											5	51					3.59834e-05	4.57629e-05	0.001168	1	0
NUP188	23511	broad.mit.edu	37	9	131715112	131715112	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:131715112T>C	uc004bws.1	+	3	170	c.148T>C	c.(148-150)TAC>CAC	p.Y50H	NUP188_uc004bwq.1_Missense_Mutation_p.Y52H	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	50					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GCTTTCTTACTACAAACCTCC	0.403			NA											3	81					0	0	0.004672	0	0
LAMC3	10319	broad.mit.edu	37	9	133911562	133911562	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:133911562C>A	uc004caa.1	+	4	917	c.819C>A	c.(817-819)TGC>TGA	p.C273*		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	273	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GGTGCAAGTGCAACGGGCATG	0.652			NA											7	61					0.00621372	0.00712032	0.006214	1	0
SETX	23064	broad.mit.edu	37	9	135158694	135158694	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:135158694C>A	uc004cbk.2	-	19	6686	c.6503G>T	c.(6502-6504)CGT>CTT	p.R2168L	SETX_uc004cbj.2_Missense_Mutation_p.R1787L|SETX_uc010mzt.2_Missense_Mutation_p.R1787L	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2168					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CCCTTGCCCACGGAAAGCAGA	0.478			NA											7	57					8.12818e-05	0.000101263	0.001984	1	0
SETX	23064	broad.mit.edu	37	9	135203189	135203189	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:135203189G>A	uc004cbk.2	-	10	3979	c.3796C>T	c.(3796-3798)CCT>TCT	p.P1266S	SETX_uc004cbj.2_Missense_Mutation_p.P885S|SETX_uc010mzt.2_Missense_Mutation_p.P885S	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1266					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ACTATAGCAGGAGTTGTTCTA	0.418			NA											10	161					0	0	0.000978	0	0
TTF1	7270	broad.mit.edu	37	9	135277138	135277138	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:135277138G>A	uc004cbl.2	-	2	1123	c.1071C>T	c.(1069-1071)TAC>TAT	p.Y357Y	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	357					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ATCCTTCAGGGTATGCACTCT	0.458			NA											8	105					0	0	0.00308	0	0
COL5A1	1289	broad.mit.edu	37	9	137688228	137688228	+	Silent	SNP	C	C	T	rs142849628		TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:137688228C>T	uc004cfe.2	+	35	3190	c.2808C>T	c.(2806-2808)TCC>TCT	p.S936S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	936	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGGCAACTCCGGAGGTGACG	0.572			NA											7	63					0	0	0.001984	0	0
FUT7	2529	broad.mit.edu	37	9	139925532	139925532	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:139925532G>T	uc004ckq.2	-	2	1508	c.659C>A	c.(658-660)GCC>GAC	p.A220D	ABCA2_uc011mel.1_5'Flank|ABCA2_uc011mem.1_5'Flank|ABCA2_uc004ckl.1_5'Flank|ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	220	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GCGGTACTGGGCCACGGTGGG	0.627			NA											25	170					6.32553e-13	1.08773e-12	0.004656	1	0
COBRA1	25920	broad.mit.edu	37	9	140151353	140151353	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:140151353G>C	uc004cmm.3	+	4	647	c.444G>C	c.(442-444)CAG>CAC	p.Q148H		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	148					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TGAAGCGGCAGATCTGGCAAG	0.562			NA											4	42					0	0	0.000248	0	0
PNPLA7	375775	broad.mit.edu	37	9	140395241	140395241	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:140395241C>A	uc004cnf.2	-	15	1921	c.1584G>T	c.(1582-1584)GTG>GTT	p.V528V	C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Silent_p.V553V	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	528	cNMP 2.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CCAGCTGGCCCACCATCTCCC	0.632			NA											9	22					0.000274275	0.000331549	0.004482	1	0
EHMT1	79813	broad.mit.edu	37	9	140637960	140637960	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:140637960C>G	uc011mfc.1	+	5	998	c.961C>G	c.(961-963)CAT>GAT	p.H321D	EHMT1_uc004coa.2_Missense_Mutation_p.H321D|EHMT1_uc004cob.1_Missense_Mutation_p.H290D|EHMT1_uc010ncn.1_RNA	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	321					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GAGCATAACTCATTCCACTGT	0.428			NA											9	46					0	0	0.004482	0	0
MXRA5	25878	broad.mit.edu	37	X	3239969	3239969	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:3239969A>T	uc004crg.3	-	5	3914	c.3757T>A	c.(3757-3759)TCC>ACC	p.S1253T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1253						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGGATCCGGACGCTCTTGAG	0.453			NA											44	121					0	0	0.002222	0	0
SHROOM2	357	broad.mit.edu	37	X	9863246	9863246	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:9863246G>A	uc004csu.1	+	4	1388	c.1298G>A	c.(1297-1299)AGC>AAC	p.S433N		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	433					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCCTATACAGCGACCACAGC	0.632			NA											20	43					0	0	0.002299	0	0
OFD1	8481	broad.mit.edu	37	X	13764935	13764935	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:13764935A>G	uc004cvp.3	+	8	1050	c.691A>G	c.(691-693)AAA>GAA	p.K231E	OFD1_uc004cvr.3_5'UTR|OFD1_uc011mil.1_5'UTR|OFD1_uc004cvq.3_Missense_Mutation_p.K91E|OFD1_uc010nen.2_Missense_Mutation_p.K230E|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.K230E|OFD1_uc004cvv.3_Missense_Mutation_p.K230E|OFD1_uc010neo.1_Missense_Mutation_p.K17E	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	231	Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						AGCAAAAATTAAAATGGAAGC	0.299			NA											14	27					0	0	0.003163	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20212340	20212340	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:20212340C>A	uc004czu.2	-	6	453	c.453G>T	c.(451-453)AGG>AGT	p.R151S	RPS6KA3_uc011mjk.1_Missense_Mutation_p.R122S|RPS6KA3_uc004czv.2_Missense_Mutation_p.R139S|RPS6KA3_uc011mjl.1_Missense_Mutation_p.R123S|RPS6KA3_uc011mjm.1_Missense_Mutation_p.R123S	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	151	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						AATCTCCTCCCCTGAGAAAAT	0.299			NA											14	24					3.41278e-10	5.4499e-10	0.00499	1	0
PHEX	5251	broad.mit.edu	37	X	22112188	22112188	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:22112188G>T	uc004dah.2	+	7	1023	c.820G>T	c.(820-822)GTG>TTG	p.V274L	PHEX_uc011mjr.1_Missense_Mutation_p.V274L|PHEX_uc011mjs.1_Missense_Mutation_p.V177L	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	274	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						CATGAAGTCAGTGCTCAGATT	0.318			NA											20	42					1.56452e-12	2.64963e-12	0.007413	1	0
MAGEB4	4115	broad.mit.edu	37	X	30260943	30260943	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:30260943G>T	uc004dcb.2	+	1	775	c.691G>T	c.(691-693)GAT>TAT	p.D231Y	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	231	MAGE.									ovary(1)	1						GGGGATCTATGATGGAAAGAG	0.473			NA											21	63					2.37509e-13	4.13716e-13	0.001523	1	0
FAM47A	158724	broad.mit.edu	37	X	34150261	34150261	+	Silent	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:34150261G>T	uc004ddg.2	-	1	168	c.135C>A	c.(133-135)ACC>ACA	p.T45T		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	45										ovary(4)|central_nervous_system(1)	5						CCCAGTTCTGGGTGTCCATGG	0.577			NA											15	36					6.31663e-08	9.24099e-08	0.003163	1	0
FAM47C	442444	broad.mit.edu	37	X	37026780	37026780	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:37026780G>C	uc004ddl.1	+	1	311	c.297G>C	c.(295-297)AAG>AAC	p.K99N		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	99										ovary(3)	3						AGCTGCTCAAGAAAGCGGCCC	0.532			NA											35	74					0	0	0.003271	0	0
FAM47C	442444	broad.mit.edu	37	X	37027491	37027491	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:37027491G>T	uc004ddl.1	+	1	1022	c.1008G>T	c.(1006-1008)AAG>AAT	p.K336N		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	336										ovary(3)	3						AGCCTCCCAAGACTCTGGTGT	0.617			NA											25	55					3.6726e-16	6.71062e-16	0.003954	1	0
SSX1	6756	broad.mit.edu	37	X	48125747	48125747	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:48125747G>C	uc004djb.1	+	7	583	c.492G>C	c.(490-492)TGG>TGC	p.W164C		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						AACATGCCTGGACCCACAGAC	0.483	Esophageal Squamous(175;994 1982 2214 6527 18857)		NA											10	298					0	0	0.000978	0	0
CACNA1F	778	broad.mit.edu	37	X	49070315	49070315	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:49070315C>A	uc004dnb.2	-	31	3851	c.3789G>T	c.(3787-3789)GTG>GTT	p.V1263V	CACNA1F_uc010nip.2_Silent_p.V1252V	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1263	IV.|Helical; Name=S3 of repeat IV; (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CTATGCTGCCCACCACAATAA	0.512			NA											11	28					1.58986e-06	2.20122e-06	0.008291	1	0
DGKK	139189	broad.mit.edu	37	X	50136178	50136178	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:50136178C>A	uc010njr.1	-	9	1627	c.1567G>T	c.(1567-1569)GAC>TAC	p.D523Y		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	523	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTCAATAAGTCGAACACTTGA	0.433			NA											4	13					1.024e-07	1.49157e-07	0.000602	1	0
GPR173	54328	broad.mit.edu	37	X	53106005	53106005	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:53106005G>T	uc004dru.2	+	2	460	c.202G>T	c.(202-204)GAT>TAT	p.D68Y		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	68	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GTGCCTGGCCGATGGCATACG	0.602			NA											22	45					4.35082e-09	6.72399e-09	0.001523	1	0
FAM120C	54954	broad.mit.edu	37	X	54161374	54161374	+	Silent	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:54161374A>G	uc004dsz.3	-	7	1589	c.1506T>C	c.(1504-1506)TCT>TCC	p.S502S	FAM120C_uc011moh.1_Silent_p.S502S	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	502										ovary(1)|central_nervous_system(1)	2						ACTGGGATGCAGAAGAGTCAT	0.517			NA											13	28					0	0	0.001855	0	0
FGD1	2245	broad.mit.edu	37	X	54497780	54497780	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:54497780G>T	uc004dtg.2	-	2	1182	c.448C>A	c.(448-450)CCA>ACA	p.P150T	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	150	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGCTTCAGTGGTGAAGGACGC	0.627			NA											19	43					5.26018e-13	9.08023e-13	0.001882	1	0
LAS1L	81887	broad.mit.edu	37	X	64734730	64734730	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:64734730C>A	uc004dwa.1	-	13	2123	c.2051G>T	c.(2050-2052)CGG>CTG	p.R684L	LAS1L_uc004dwc.1_Missense_Mutation_p.R667L|LAS1L_uc004dwd.1_Missense_Mutation_p.R625L|LAS1L_uc004dvy.1_Missense_Mutation_p.R197L|LAS1L_uc004dvz.1_Missense_Mutation_p.R197L	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	684						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						GGGTTCCAGCCGCTGCTCTAG	0.557			NA											6	9					3.59834e-05	4.57629e-05	0.001168	1	0
MSN	4478	broad.mit.edu	37	X	64949300	64949300	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:64949300G>C	uc004dwf.2	+	4	391	c.193G>C	c.(193-195)GTG>CTG	p.V65L		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	65	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CTCTTCCCAGGTGACTGCCCA	0.478			NA	T	ALK	ALCL								14	70					0	0	0.004007	0	0
EDA2R	60401	broad.mit.edu	37	X	65819692	65819692	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:65819692C>A	uc004dwq.2	-	5	539	c.528G>T	c.(526-528)CTG>CTT	p.L176L	EDA2R_uc004dwr.2_Silent_p.L176L|EDA2R_uc004dws.2_Silent_p.L176L|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Silent_p.L52L|EDA2R_uc010nkt.1_Silent_p.L176L|EDA2R_uc004dwt.1_Silent_p.L197L	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	176	Cytoplasmic (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CCTCAAACTGCAGCAAACCTC	0.522			NA											12	16					1.05317e-09	1.65622e-09	0.00245	1	0
AR	367	broad.mit.edu	37	X	66937402	66937402	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:66937402G>C	uc004dwu.1	+	5	3371	c.2256G>C	c.(2254-2256)TGG>TGC	p.W752C	AR_uc004dwv.1_Missense_Mutation_p.W220C	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	751	Ligand-binding.|Interaction with MYST2.		W -> R (in AIS).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CCATGGGCTGGCGATCCTTCA	0.532			NA							Androgen_Insensitivity_Syndrome				11	34					0	0	0.001368	0	0
NLGN3	54413	broad.mit.edu	37	X	70387517	70387517	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:70387517G>T	uc004dzd.1	+	6	1770	c.1570G>T	c.(1570-1572)GGG>TGG	p.G524W	NLGN3_uc010nlb.1_Missense_Mutation_p.G484W|NLGN3_uc004dzb.2_Missense_Mutation_p.G504W|NLGN3_uc004dzc.2_Missense_Mutation_p.G387W|NLGN3_uc011mps.1_Missense_Mutation_p.G484W|NLGN3_uc004dze.2_Missense_Mutation_p.G322W	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	524	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					TGCAGCTCATGGGGATGAAGT	0.527	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											20	87					8.34094e-07	1.16323e-06	0.001216	1	0
RGAG4	340526	broad.mit.edu	37	X	71351060	71351060	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:71351060G>C	uc010nlh.1	-	1	692	c.331C>G	c.(331-333)CGC>GGC	p.R111G	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	111										ovary(2)|skin(1)	3	Renal(35;0.156)					GGGGTGCTGCGATCCTGGATC	0.692			NA											3	11					0	0	0.004672	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433573	72433573	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:72433573A>T	uc004ebi.2	-	1	1112	c.756T>A	c.(754-756)GAT>GAA	p.D252E	NAP1L2_uc011mqj.1_Missense_Mutation_p.D110E	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	252					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					GAGTGAGTGTATCAACGTTTT	0.378			NA											4	46					0	0	0.000602	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962851	73962851	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:73962851C>A	uc004eby.2	-	3	2158	c.1541G>T	c.(1540-1542)GGT>GTT	p.G514V		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	514					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTCTTTGGAACCAACTGGCAG	0.398			NA											10	26					1.58986e-06	2.20122e-06	0.008291	1	0
MAGEE2	139599	broad.mit.edu	37	X	75003786	75003786	+	Silent	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:75003786A>T	uc004ecj.1	-	1	1286	c.1101T>A	c.(1099-1101)TCT>TCA	p.S367S		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	367	MAGE 2.									ovary(1)|skin(1)	2						CCTCAATCAGAGACAACCCAT	0.458			NA											17	50					0	0	0.00499	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913554	77913554	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:77913554C>A	uc004edc.1	-	2	660	c.364G>T	c.(364-366)GAG>TAG	p.E122*		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	122	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						TTCTGGGACTCCCGGGTTGCT	0.627			NA											9	10					0.000274275	0.000331549	0.004482	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177312	89177312	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:89177312C>A	uc004efe.2	+	2	277	c.228C>A	c.(226-228)GCC>GCA	p.A76A		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	76	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GGTTTAAGGCCTACCCTTCAG	0.468			NA											22	57					3.11337e-16	5.71211e-16	0.002836	1	0
ARMCX2	9823	broad.mit.edu	37	X	100910689	100910689	+	Missense_Mutation	SNP	A	A	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:100910689A>G	uc004eid.2	-	3	2241	c.1886T>C	c.(1885-1887)GTG>GCG	p.V629A	ARMCX2_uc004eie.3_Missense_Mutation_p.V629A|ARMCX2_uc004eif.3_Missense_Mutation_p.V629A|ARMCX2_uc004eig.3_Missense_Mutation_p.V629A|ARMCX2_uc010nnt.2_Missense_Mutation_p.V629A	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	629						integral to membrane	binding			ovary(6)	6						GAATTTGTTCACTAGTTTTAT	0.249			NA											15	67					0	0	0.003163	0	0
NXF5	55998	broad.mit.edu	37	X	101096947	101096947	+	Splice_Site	SNP	T	T	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:101096947T>A	uc011mrk.1	-	4	412	c.52_splice	c.e4-1	p.I18_splice	NXF5_uc004eih.1_Splice_Site|NXF5_uc004eii.1_Splice_Site|NXF5_uc004eij.1_Splice_Site|NXF5_uc004eik.1_Intron|NXF5_uc004eil.1_Intron	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5						mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						ATAAGGAATCTAAGCATAAAA	0.398			NA											38	62					0	0	0.003755	0	0
H2BFWT	158983	broad.mit.edu	37	X	103267967	103267967	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:103267967A>T	uc004elr.2	-	1	290	c.266T>A	c.(265-267)CTG>CAG	p.L89Q		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	89					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AACCTGCTTCAGCACCCGGCG	0.627			NA											6	40					0	0	0.001984	0	0
COL4A6	1288	broad.mit.edu	37	X	107407909	107407909	+	Silent	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:107407909G>A	uc004enw.3	-	40	4096	c.3993C>T	c.(3991-3993)GGC>GGT	p.G1331G	COL4A6_uc004env.3_Silent_p.G1330G|COL4A6_uc011msn.1_Silent_p.G1306G|COL4A6_uc010npk.2_Intron|COL4A6_uc010npj.2_5'Flank	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1331	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						TCCCCATGAAGCCAGGCTCAC	0.597	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				23	36					0	0	0.00278	0	0
CAPN6	827	broad.mit.edu	37	X	110490691	110490691	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:110490691C>A	uc004epc.1	-	12	1816	c.1648G>T	c.(1648-1650)GTC>TTC	p.V550F	CAPN6_uc011msu.1_Missense_Mutation_p.V295F	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	550	C2.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						GGAGAACGGACTTCCTCCTTT	0.393			NA											23	60					2.89027e-11	4.77445e-11	0.002299	1	0
ODZ1	10178	broad.mit.edu	37	X	123838989	123838989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:123838989G>A	uc004euj.2	-	5	953	c.889C>T	c.(889-891)CGA>TGA	p.R297*	ODZ1_uc011muj.1_Nonsense_Mutation_p.R297*|ODZ1_uc010nqy.2_Nonsense_Mutation_p.R297*	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	297	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AAGGTGCTTCGAGGAAGAGGC	0.522			NA											10	149					0	0	0.008291	0	0
ODZ1	10178	broad.mit.edu	37	X	123839041	123839041	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:123839041G>T	uc004euj.2	-	5	901	c.837C>A	c.(835-837)AAC>AAA	p.N279K	ODZ1_uc011muj.1_Missense_Mutation_p.N279K|ODZ1_uc010nqy.2_Missense_Mutation_p.N279K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	279	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCAGAGGGTAGTTCTGACTGG	0.483			NA											34	84					3.67414e-24	7.19296e-24	0.002445	1	0
OCRL	4952	broad.mit.edu	37	X	128692884	128692884	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:128692884T>C	uc004euq.2	+	8	793	c.628T>C	c.(628-630)TTT>CTT	p.F210L	OCRL_uc004eur.2_Missense_Mutation_p.F210L	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	210					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						GCGGAAGCTCTTTGTACCAAA	0.428			NA											20	46					0	0	0.001882	0	0
FGF13	2258	broad.mit.edu	37	X	137715014	137715014	+	Silent	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:137715014C>A	uc004fam.2	-	5	1397	c.735G>T	c.(733-735)ACG>ACT	p.T245T	FGF13_uc004fan.2_Silent_p.T192T|FGF13_uc011mwi.1_Silent_p.T226T|FGF13_uc004faq.2_Silent_p.T255T|FGF13_uc004far.2_Silent_p.T226T|FGF13_uc011mwj.1_Silent_p.T255T|FGF13_uc011mwk.1_Silent_p.T199T	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	245					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TCACTGGCTACGTTGATTCAT	0.502			NA											50	120					4.29476e-34	8.59592e-34	0.00361	1	0
SLITRK4	139065	broad.mit.edu	37	X	142718335	142718335	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:142718335C>A	uc004fbx.2	-	2	966	c.590G>T	c.(589-591)GGG>GTG	p.G197V	SLITRK4_uc004fby.2_Missense_Mutation_p.G197V	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	197	Extracellular (Potential).|LRR 6.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCAGAACCCCGATATAAGG	0.438			NA											26	48					1.85244e-09	2.88946e-09	0.00333	1	0
TREX2	11219	broad.mit.edu	37	X	152710395	152710395	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:152710395C>A	uc010nue.1	-	3	736	c.620G>T	c.(619-621)CGG>CTG	p.R207L	TREX2_uc010nud.1_Missense_Mutation_p.R165L|TREX2_uc011myp.1_Missense_Mutation_p.R165L|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	208					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGCGGCCCCGGGCCCGGGT	0.756			NA						Editing_and_processing_nucleases					3	11					0.004672	0.00538583	0.004672	1	0
GAB3	139716	broad.mit.edu	37	X	153941501	153941501	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chrX:153941501C>G	uc004fmj.1	-	3	622	c.574G>C	c.(574-576)GGA>CGA	p.G192R	GAB3_uc004fmk.1_Missense_Mutation_p.G193R|GAB3_uc010nve.1_Missense_Mutation_p.G193R|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	192										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGCAGTCTTCCAGTCTCGCAG	0.517			NA											3	87					0	0	0.004672	0	0
CDC7	8317	broad.mit.edu	37	1	91979544	91979544	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr1:91979544delG	uc001doe.2	+	8	1027	c.862delG	c.(862-864)GGAfs	p.G288fs	CDC7_uc001dof.2_Frame_Shift_Del_p.G288fs|CDC7_uc010osw.1_Frame_Shift_Del_p.G260fs|CDC7_uc009wdc.2_Frame_Shift_Del_p.G288fs|CDC7_uc009wdd.2_5'Flank	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	288	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		CTCTGTTTTTGGAGAAAGAAA	0.393			NA											14	43	---	---	---	---	NA	NA	NA	NA	NA
ADARB2	105	broad.mit.edu	37	10	1405671	1405671	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:1405671delG	uc009xhq.2	-	3	1003	c.629delC	c.(628-630)ACGfs	p.T210fs		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	210			T -> M (in a colorectal cancer sample; somatic mutation).		mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding	p.T210M(1)		large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GGTGAAGTCCGTgccggggcc	0.433			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
AP3M1	26985	broad.mit.edu	37	10	75883569	75883569	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:75883569delC	uc001jwf.2	-	9	1686	c.1256delG	c.(1255-1257)TGAfs	p.*419fs	AP3M1_uc001jwg.2_Frame_Shift_Del_p.*419fs|AP3M1_uc001jwh.2_Frame_Shift_Del_p.*419fs|AP3M1_uc010qla.1_Frame_Shift_Del_p.*365fs	NM_207012	NP_996895	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	419					protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding				0	Prostate(51;0.0112)					GGCCTCTTCTCATGTCCTCAC	0.393			NA											33	71	---	---	---	---	NA	NA	NA	NA	NA
CDHR1	92211	broad.mit.edu	37	10	85974197	85974197	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr10:85974197delG	uc001kcv.2	+	17	2400	c.2400delG	c.(2398-2400)GTGfs	p.V800fs	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Frame_Shift_Del_p.V504fs|CDHR1_uc001kcx.2_Frame_Shift_Del_p.V114fs	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	800	Cytoplasmic (Potential).|Pro-rich.				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CACCCAGCGTGGCGCCCAGCA	0.597			NA											37	91	---	---	---	---	NA	NA	NA	NA	NA
DENND5A	23258	broad.mit.edu	37	11	9163520	9163520	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:9163520delC	uc001mhl.2	-	22	3902	c.3647delG	c.(3646-3648)GGCfs	p.G1216fs	DENND5A_uc001mhk.2_Frame_Shift_Del_p.G559fs|DENND5A_uc010rbw.1_Splice_Site_p.E1216_splice	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1216	RUN 2.									liver(1)	1						CTGAAACTTGCCATCCTTGCC	0.552			NA											12	40	---	---	---	---	NA	NA	NA	NA	NA
OR8I2	120586	broad.mit.edu	37	11	55861592	55861592	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:55861592delC	uc010rix.1	+	1	809	c.809delC	c.(808-810)GCGfs	p.A270fs		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					CTGACCCAGGCGCAGGTGGCA	0.453			NA											22	110	---	---	---	---	NA	NA	NA	NA	NA
SORL1	6653	broad.mit.edu	37	11	121429484	121429484	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr11:121429484delG	uc001pxx.2	+	20	2928	c.2848delG	c.(2848-2850)GGCfs	p.G950fs		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	950	Extracellular (Potential).|LDL-receptor class B 4.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CACGTTCAGTGGCCAGCAGCG	0.552			NA											19	66	---	---	---	---	NA	NA	NA	NA	NA
GDF3	9573	broad.mit.edu	37	12	7848269	7848269	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:7848269delC	uc001qte.2	-	1	92	c.56delG	c.(55-57)GGCfs	p.G19fs		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	19					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GACTGCCTGGCCCAAAGCCAG	0.498			NA											8	50	---	---	---	---	NA	NA	NA	NA	NA
SCN8A	6334	broad.mit.edu	37	12	52093524	52093525	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr12:52093524_52093525insT	uc001ryw.2	+	7	1055_1056	c.877_878insT	c.(877-879)CTTfs	p.L293fs	SCN8A_uc010snl.1_Frame_Shift_Ins_p.L158fs|SCN8A_uc001ryx.1_Frame_Shift_Ins_p.L158fs|SCN8A_uc001ryz.1_Frame_Shift_Ins_p.L158fs|SCN8A_uc001ryy.2_Frame_Shift_Ins_p.L158fs	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	293	I.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CGAGAGCTATCTTGAAAATGGC	0.436			NA											9	25	---	---	---	---	NA	NA	NA	NA	NA
NAA16	79612	broad.mit.edu	37	13	41933096	41933097	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:41933096_41933097insG	uc001uyf.2	+	12	1732_1733	c.1408_1409insG	c.(1408-1410)AGGfs	p.R470fs	NAA16_uc010tfg.1_RNA	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	470					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						CAAGTTCACAAGGGTAGGAAAT	0.356			NA											33	94	---	---	---	---	NA	NA	NA	NA	NA
EDNRB	1910	broad.mit.edu	37	13	78492477	78492477	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr13:78492477delC	uc001vko.2	-	1	490	c.232delG	c.(232-234)GCAfs	p.A78fs	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Frame_Shift_Del_p.A78fs|EDNRB_uc010aez.1_Frame_Shift_Del_p.A78fs|EDNRB_uc001vkp.1_Frame_Shift_Del_p.A161fs|EDNRB_uc010afa.1_Frame_Shift_Del_p.A78fs	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	78	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GGAGATCCTGCCGTCCTGTCT	0.582			NA											16	71	---	---	---	---	NA	NA	NA	NA	NA
PRKCH	5583	broad.mit.edu	37	14	62016430	62016430	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:62016430delG	uc001xfn.2	+	14	2238	c.1933delG	c.(1933-1935)GACfs	p.D645fs	PRKCH_uc010tsa.1_Frame_Shift_Del_p.D484fs|PRKCH_uc010tsb.1_Frame_Shift_Del_p.D213fs|PRKCH_uc001xfo.2_RNA	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	645	AGC-kinase C-terminal.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CAGTAATTTTGACCCTGACTT	0.398	Melanoma(135;863 1779 8064 14443 26348)		NA											31	81	---	---	---	---	NA	NA	NA	NA	NA
BTBD7	55727	broad.mit.edu	37	14	93719992	93719992	+	Splice_Site	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr14:93719992delC	uc001ybo.2	-	7	2078	c.1752_splice	c.e7+1	p.K584_splice	BTBD7_uc010aur.2_Splice_Site_p.K109_splice|BTBD7_uc010two.1_Splice_Site_p.K404_splice|BTBD7_uc001ybp.2_Splice_Site_p.K233_splice	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1											pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		GTTTTCATTACCTTTGCTTCT	0.289			NA											30	77	---	---	---	---	NA	NA	NA	NA	NA
SGCA	6442	broad.mit.edu	37	17	48245032	48245033	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr17:48245032_48245033insA	uc002iqi.2	+	3	283_284	c.247_248insA	c.(247-249)CCCfs	p.P83fs	SGCA_uc010wmh.1_Intron|SGCA_uc002iqj.2_Frame_Shift_Ins_p.P83fs|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	83	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						CCAGCGCAGCCCCCACCACCCT	0.658			NA											7	29	---	---	---	---	NA	NA	NA	NA	NA
SERPINB11	89778	broad.mit.edu	37	18	61390628	61390628	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr18:61390628delC	uc002ljk.3	+	9	1236	c.1174delC	c.(1174-1176)CCCfs	p.P392fs	SERPINB11_uc010xes.1_Frame_Shift_Del_p.P217fs|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Frame_Shift_Del_p.P278fs|SERPINB11_uc010dqe.2_Frame_Shift_Del_p.P191fs|SERPINB11_uc010dqf.2_Frame_Shift_Del_p.P190fs	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	392					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GCTTGCCTCTCCCTAATCAGA	0.488	Ovarian(27;496 784 5942 8975 23930)		NA											20	78	---	---	---	---	NA	NA	NA	NA	NA
CAPN12	147968	broad.mit.edu	37	19	39227940	39227941	+	Frame_Shift_Ins	INS	-	-	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr19:39227940_39227941insC	uc002ojd.1	-	10	1526_1527	c.1217_1218insG	c.(1216-1218)GGCfs	p.G406fs	CAPN12_uc010egd.1_5'Flank|CAPN12_uc002ojc.1_5'Flank	NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	406	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CAGCCCCCCAGCCCCCCCAGGG	0.673			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MPHOSPH10	10199	broad.mit.edu	37	2	71360643	71360645	+	In_Frame_Del	DEL	TTT	TTT	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	TTT	TTT	-	-	TTT	TTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:71360643_71360645delTTT	uc002sht.1	+	2	1057_1059	c.705_707delTTT	c.(703-708)GATTTT>GAT	p.F237del	MPHOSPH10_uc010feb.1_In_Frame_Del_p.F237del	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	237	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AAGATATTGATTTTTTTGAAGAT	0.34			NA											26	72	---	---	---	---	NA	NA	NA	NA	NA
RIF1	55183	broad.mit.edu	37	2	152292047	152292048	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:152292047_152292048insT	uc002txm.2	+	11	1278_1279	c.1148_1149insT	c.(1147-1149)CATfs	p.H383fs	RIF1_uc002txl.2_Frame_Shift_Ins_p.H383fs|RIF1_uc010fnv.1_Frame_Shift_Ins_p.H347fs|RIF1_uc002txn.2_Frame_Shift_Ins_p.H383fs|RIF1_uc002txo.2_Frame_Shift_Ins_p.H383fs|RIF1_uc010zby.1_Intron	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	383					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATTCGTGTCATGTAGCTACAT	0.376			NA											44	140	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179554591	179554591	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:179554591delC	uc010zfg.1	-	119	28287	c.28063delG	c.(28063-28065)GAAfs	p.E9355fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.E6016fs|TTN_uc010fre.1_Frame_Shift_Del_p.E466fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10282							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAATCTTTTCTTCAGGGACA	0.393			NA											72	214	---	---	---	---	NA	NA	NA	NA	NA
WDR75	84128	broad.mit.edu	37	2	190340074	190340074	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr2:190340074delG	uc002uql.1	+	21	2484	c.2424delG	c.(2422-2424)TTGfs	p.L808fs	WDR75_uc002uqm.1_Frame_Shift_Del_p.L744fs|WDR75_uc002uqn.1_Frame_Shift_Del_p.L586fs|WDR75_uc002uqo.1_Frame_Shift_Del_p.L586fs	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	808						nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			TACATCAGTTGTCAAAATCTG	0.363			NA											19	46	---	---	---	---	NA	NA	NA	NA	NA
KCTD8	386617	broad.mit.edu	37	4	44177021	44177021	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:44177021delG	uc003gwu.2	-	2	1492	c.1208delC	c.(1207-1209)CCAfs	p.P403fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	403						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TTTGTCTGGTGGGGGTATCCA	0.483			NA								HNSCC(17;0.042)			44	294	---	---	---	---	NA	NA	NA	NA	NA
EPHA5	2044	broad.mit.edu	37	4	66467435	66467435	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr4:66467435delG	uc003hcy.2	-	3	1027	c.834delC	c.(832-834)GCCfs	p.A278fs	EPHA5_uc003hcx.2_Frame_Shift_Del_p.A209fs|EPHA5_uc003hcz.2_Frame_Shift_Del_p.A278fs|EPHA5_uc011cah.1_Frame_Shift_Del_p.A278fs|EPHA5_uc011cai.1_Frame_Shift_Del_p.A278fs|EPHA5_uc003hda.2_Frame_Shift_Del_p.A278fs	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	278	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ACTCCCCTTCGGCGCTGCAGT	0.522			NA								TSP Lung(17;0.13)			9	65	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS12	81792	broad.mit.edu	37	5	33546184	33546184	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33546184delC	uc003jia.1	-	22	4589	c.4426delG	c.(4426-4428)GCCfs	p.A1476fs	ADAMTS12_uc010iuq.1_Frame_Shift_Del_p.A1391fs	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1476	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTCCCAGTGGCCCAGTGACAG	0.378			NA								HNSCC(64;0.19)			7	88	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS12	81792	broad.mit.edu	37	5	33561259	33561260	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:33561259_33561260insT	uc003jia.1	-	20	4160_4161	c.3997_3998insA	c.(3997-3999)GCCfs	p.A1333fs	ADAMTS12_uc010iuq.1_Frame_Shift_Ins_p.A1248fs	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1333	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTCCAGTAGGCCCCCAGGCCA	0.584			NA								HNSCC(64;0.19)			14	80	---	---	---	---	NA	NA	NA	NA	NA
SPEF2	79925	broad.mit.edu	37	5	35709195	35709196	+	Frame_Shift_Ins	INS	-	-	C			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:35709195_35709196insC	uc003jjo.2	+	19	2922_2923	c.2811_2812insC	c.(2809-2814)ACTCCTfs	p.T937fs	SPEF2_uc003jjq.3_Frame_Shift_Ins_p.T932fs|SPEF2_uc003jjp.1_Frame_Shift_Ins_p.T423fs	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	937_938					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTCAAAAACTCCTACTGCAAA	0.386			NA											18	118	---	---	---	---	NA	NA	NA	NA	NA
HTR1A	3350	broad.mit.edu	37	5	63257309	63257309	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:63257309delC	uc011cqt.1	-	1	238	c.238delG	c.(238-240)GTCfs	p.V80fs		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	80	Helical; Name=2; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGGTCGGTGACCGCCAAAGAG	0.597			NA											8	15	---	---	---	---	NA	NA	NA	NA	NA
DRD1	1812	broad.mit.edu	37	5	174869076	174869076	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr5:174869076delT	uc003mcz.2	-	2	1972	c.1027delA	c.(1027-1029)ACCfs	p.T343fs		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	343	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	CCTAAGAGGGTTGAAAATGCC	0.453			NA											35	52	---	---	---	---	NA	NA	NA	NA	NA
SIM1	6492	broad.mit.edu	37	6	100838281	100838281	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:100838281delG	uc003pqj.3	-	11	2464	c.2257delC	c.(2257-2259)CAAfs	p.Q753fs	SIM1_uc010kcu.2_Frame_Shift_Del_p.Q753fs	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	753	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TTGTGTCCTTGTGCTGGGTCT	0.383			NA											32	110	---	---	---	---	NA	NA	NA	NA	NA
C6orf118	168090	broad.mit.edu	37	6	165711542	165711542	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr6:165711542delC	uc003qum.3	-	5	1021	c.985delG	c.(985-987)GCGfs	p.A329fs	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	329											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TCCATGTCCGCCGTCTTCACC	0.602			NA											15	49	---	---	---	---	NA	NA	NA	NA	NA
DLX5	1749	broad.mit.edu	37	7	96653778	96653778	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr7:96653778delC	uc003uon.2	-	1	366	c.158delG	c.(157-159)GGAfs	p.G53fs	DLX5_uc011kim.1_Frame_Shift_Del_p.G53fs	NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	53					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GTGCGGGGCTCCCCCCGTAGG	0.602			NA											14	62	---	---	---	---	NA	NA	NA	NA	NA
POP1	10940	broad.mit.edu	37	8	99146751	99146751	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:99146751delT	uc003yij.3	+	7	975	c.875delT	c.(874-876)CTTfs	p.L292fs	POP1_uc011lgv.1_Frame_Shift_Del_p.L292fs|POP1_uc003yik.2_Frame_Shift_Del_p.L292fs	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	292					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CAAGGGAGCCTTGTGCTTTAT	0.502			NA											19	68	---	---	---	---	NA	NA	NA	NA	NA
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr8:110455173_110455174insG	uc003yne.2	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322			NA								HNSCC(38;0.096)			9	127	---	---	---	---	NA	NA	NA	NA	NA
ADAMTSL1	92949	broad.mit.edu	37	9	18906757	18906758	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:18906757_18906758insT	uc003zne.3	+	28	5156_5157	c.5029_5030insT	c.(5029-5031)CTGfs	p.L1677fs	ADAMTSL1_uc003znf.3_Frame_Shift_Ins_p.L378fs|ADAMTSL1_uc003zng.1_Frame_Shift_Ins_p.L68fs	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1677	TSP type-1 9.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTGTGGACCCTGTGCACAGCT	0.614			NA											10	15	---	---	---	---	NA	NA	NA	NA	NA
TMEM2	23670	broad.mit.edu	37	9	74324265	74324266	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-86-6851-01A-11D-1945-08	TCGA-86-6851-10A-01D-1946-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5a79ea9-4b65-4e69-bed1-79919e2639d7	4b0090ac-8a7d-463b-a3be-c2cb6f0ac7dc	g.chr9:74324265_74324266delCA	uc011lsa.1	-	17	3434_3435	c.2894_2895delTG	c.(2893-2895)GTGfs	p.V965fs	TMEM2_uc010mos.2_Frame_Shift_Del_p.V902fs|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	965						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CCATTCTTCCCACATAAGCATC	0.465			NA											9	89	---	---	---	---	NA	NA	NA	NA	NA
