Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17084510	17084510	+	Silent	SNP	G	G	A	rs61769731	by1000genomes	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:17084510G>A	uc010ock.1	-	12	1588	c.1588C>T	c.(1588-1590)CTA>TTA	p.L530L	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.L130L	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCCGCTGTAGGCCTGGCTCT	0.577			NA											5	83					0	0	0.001168	0	0
RCC1	1104	broad.mit.edu	37	1	28863368	28863368	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:28863368G>T	uc001bqg.1	+	9	1132	c.1047G>T	c.(1045-1047)TCG>TCT	p.S349S	SNHG3-RCC1_uc001bqa.1_Silent_p.S349S|SNHG3-RCC1_uc001bqb.1_Silent_p.S349S|SNHG3-RCC1_uc001bqc.1_Silent_p.S349S|RCC1_uc001bqe.1_Silent_p.S366S|RCC1_uc001bqf.1_Silent_p.S380S	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	349	RCC1 6.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCTCCTCGGTGGCTTGTG	0.622			NA											39	226					4.65455e-14	7.01877e-14	0.00361	1	0
CSMD2	114784	broad.mit.edu	37	1	34003151	34003151	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:34003151G>A	uc001bxn.1	-	60	9287	c.9258C>T	c.(9256-9258)TTC>TTT	p.F3086F	CSMD2_uc001bxm.1_Silent_p.F3230F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3086	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCTGTAGGAGAAGCCTCGGT	0.602			NA											4	65					0	0	0.000248	0	0
NTNG1	22854	broad.mit.edu	37	1	107866979	107866979	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:107866979G>C	uc001dvh.3	+	3	1040	c.322G>C	c.(322-324)GAT>CAT	p.D108H	NTNG1_uc001dvf.3_Missense_Mutation_p.D108H|NTNG1_uc010out.1_Missense_Mutation_p.D108H|NTNG1_uc001dvc.3_Missense_Mutation_p.D108H|NTNG1_uc001dvd.1_Missense_Mutation_p.D108H	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	108	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GCTGATGTTTGATTTTGAAGG	0.488			NA											4	212					0	0	0.000248	0	0
CELF3	11189	broad.mit.edu	37	1	151681551	151681551	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:151681551A>T	uc001eys.1	-	5	1203	c.409T>A	c.(409-411)TGC>AGC	p.C137S	CELF3_uc010pdh.1_5'Flank|CELF3_uc001eyr.2_Missense_Mutation_p.C136S|CELF3_uc009wmy.2_Missense_Mutation_p.C137S|CELF3_uc009wmx.1_Missense_Mutation_p.C137S|CELF3_uc001eyt.2_Missense_Mutation_p.C60S|CELF3_uc010pdi.1_Missense_Mutation_p.C137S|C1orf230_uc001eyu.2_5'Flank	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	137	RRM 2.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						ACGAAGGCGCAGCCTGGAGAG	0.667			NA											17	115					0	0	0.002299	0	0
NES	10763	broad.mit.edu	37	1	156641024	156641024	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:156641024C>T	uc001fpq.2	-	4	3089	c.2956G>A	c.(2956-2958)GAT>AAT	p.D986N		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	986	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGAAGCCATCCTGCTCCCTC	0.592			NA											11	525					0	0	0.004007	0	0
FCRL5	83416	broad.mit.edu	37	1	157514290	157514290	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:157514290G>A	uc001fqu.2	-	5	764	c.606C>T	c.(604-606)ATC>ATT	p.I202I	FCRL5_uc009wsm.2_Silent_p.I202I|FCRL5_uc010phv.1_Silent_p.I202I|FCRL5_uc010phw.1_Silent_p.I117I|FCRL5_uc001fqv.1_Silent_p.I202I|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	202	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GGTTCCCGCTGATGGGCTGGA	0.562			NA											5	117					0	0	0.001168	0	0
GPA33	10223	broad.mit.edu	37	1	167032927	167032927	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:167032927C>A	uc001gea.1	-	4	807	c.463G>T	c.(463-465)GGG>TGG	p.G155W		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	155	Ig-like C2-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						ATGTTGTTCCCAATTATGGTC	0.547			NA											21	145					6.32553e-13	9.38946e-13	0.004656	1	0
TNR	7143	broad.mit.edu	37	1	175335167	175335167	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:175335167T>G	uc001gkp.1	-	9	2242	c.2161A>C	c.(2161-2163)ACC>CCC	p.T721P	TNR_uc009wwu.1_Missense_Mutation_p.T721P	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	721	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAGGATGGGGTAAAGGTAATT	0.552			NA											7	95					0	0	0.004482	0	0
C1orf157	284573	broad.mit.edu	37	1	204009392	204009392	+	Splice_Site	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:204009392C>A	uc001haj.2	-	2		c.303_splice	c.e2+1		C1orf157_uc001hak.2_Splice_Site|C1orf157_uc010pqo.1_Splice_Site	NR_027902				Homo sapiens cDNA FLJ40343 fis, clone TESTI2032774.												0	all_cancers(21;0.083)|Breast(84;0.193)|all_epithelial(62;0.21)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0754)|Kidney(21;0.0934)|Epithelial(59;0.233)			CATATCCACACCAGTGAGAGC	0.368			NA											5	18					0.00198382	0.00227064	0.001984	1	0
RYR2	6262	broad.mit.edu	37	1	237813214	237813214	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:237813214A>T	uc001hyl.1	+	50	7670	c.7550A>T	c.(7549-7551)AAT>ATT	p.N2517I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2517	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGGCCCTCAATCGGTACCTT	0.463			NA											28	132					0	0	0.004289	0	0
ADSS	159	broad.mit.edu	37	1	244580948	244580948	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:244580948A>G	uc001iaj.2	-	10	1346	c.1052T>C	c.(1051-1053)ATG>ACG	p.M351T		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	351					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	TCCATTGATCATATGAGCATA	0.363			NA											9	65					0	0	0.000978	0	0
CDH23	64072	broad.mit.edu	37	10	73406352	73406352	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:73406352G>T	uc001jrx.3	+	13	1804	c.1427G>T	c.(1426-1428)GGG>GTG	p.G476V	CDH23_uc001jrw.3_Missense_Mutation_p.G476V|CDH23_uc001jry.2_Missense_Mutation_p.G92V|CDH23_uc001jrz.2_Missense_Mutation_p.G92V	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	476	Cadherin 5.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GTCACCGTGGGGACCTCTGTG	0.562			NA											24	167					1.99505e-19	3.21237e-19	0.002445	1	0
PIPSL	266971	broad.mit.edu	37	10	95720433	95720433	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:95720433G>T	uc009xuj.2	-	1	1240	c.721C>A	c.(721-723)CTT>ATT	p.L241I		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						TCCAAAAAAAGACCATCAGGG	0.488			NA											9	46					1.58986e-06	2.05493e-06	0.008291	1	0
RPL13AP6	644511	broad.mit.edu	37	10	112696573	112696573	+	Missense_Mutation	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:112696573T>C	uc010qrh.1	-	1	441	c.419A>G	c.(418-420)CAC>CGC	p.H140R	SHOC2_uc001kzl.3_Intron|SHOC2_uc009xxx.2_Intron|SHOC2_uc010qrg.1_Intron	NR_026715				SubName: Full=cDNA FLJ51256, highly similar to 60S ribosomal protein L13a;												0						GTGAGCCAGGTGCCCCAGATA	0.537			NA											2	9					0	0	0.004672	0	0
HMX2	3167	broad.mit.edu	37	10	124908149	124908149	+	Silent	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:124908149T>C	uc001lhc.1	+	1	512	c.255T>C	c.(253-255)CCT>CCC	p.P85P		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	85					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		CCCCCATCCCTTTTCCTTGCC	0.711			NA											3	64					0	0	0.000248	0	0
MUC5B	727897	broad.mit.edu	37	11	1263477	1263477	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:1263477G>A	uc009ycr.1	+	47	7572	c.7446G>A	c.(7444-7446)GAG>GAA	p.E2482E	MUC5B_uc001ltb.2_Silent_p.E1792E	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1789	7 X Cys-rich subdomain repeats.|Thr-rich.|Cys-rich subdomain 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGAAGTGTGAGTGGACAGAGT	0.587			NA											13	97					0	0	0.00245	0	0
TRIM21	6737	broad.mit.edu	37	11	4409573	4409573	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:4409573T>A	uc001lyy.1	-	4	805	c.692A>T	c.(691-693)GAG>GTG	p.E231V		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	231	Potential.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		TCGATCTAGCTCTGAGATGAG	0.557			NA											10	67					0	0	0.000978	0	0
OR51V1	283111	broad.mit.edu	37	11	5221240	5221240	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:5221240G>A	uc010qyz.1	-	1	691	c.691C>T	c.(691-693)CTT>TTT	p.L231F		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGACTTAAGAATCAGGATG	0.433			NA											8	53					0	0	0.00308	0	0
PSMA1	5682	broad.mit.edu	37	11	14526749	14526749	+	Missense_Mutation	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:14526749T>C	uc001mlk.2	-	10	927	c.781A>G	c.(781-783)ATG>GTG	p.M261V	PSMA1_uc001mll.2_Missense_Mutation_p.M267V|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.M236V	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	261					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						TAATGTTCCATTGGTTCATCA	0.333			NA											20	174					0	0	0.001786	0	0
PTPN5	84867	broad.mit.edu	37	11	18755170	18755170	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:18755170C>G	uc001mpd.2	-	10	1444	c.1013G>C	c.(1012-1014)AGA>ACA	p.R338T	PTPN5_uc001mpb.2_Missense_Mutation_p.R306T|PTPN5_uc001mpc.2_Missense_Mutation_p.R338T|PTPN5_uc001mpe.2_Missense_Mutation_p.R306T|PTPN5_uc010rdj.1_Missense_Mutation_p.R282T|PTPN5_uc001mpf.2_Missense_Mutation_p.R314T|PTPN5_uc010rdk.1_Missense_Mutation_p.R283T	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	338	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						CAGACACACTCTGCTGTGAGG	0.572			NA											5	116					0	0	0.000602	0	0
OR4C15	81309	broad.mit.edu	37	11	55321821	55321821	+	Silent	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55321821A>T	uc010rig.1	+	1	39	c.39A>T	c.(37-39)GCA>GCT	p.A13A		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATAATTTTGCACTTGGATGTA	0.323			NA								HNSCC(20;0.049)			16	84					0	0	0.006122	0	0
OR8H3	390152	broad.mit.edu	37	11	55890560	55890560	+	Missense_Mutation	SNP	T	T	A	rs143312423		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55890560T>A	uc001nii.1	+	1	712	c.712T>A	c.(712-714)TTC>ATC	p.F238I		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					GCAGAAAGCTTTCTCTACTTG	0.403			NA											11	70					0	0	0.000978	0	0
OR8J3	81168	broad.mit.edu	37	11	55904714	55904714	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55904714G>T	uc010riz.1	-	1	481	c.481C>A	c.(481-483)CCT>ACT	p.P161T		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					AATATACAAGGTGAAACCACA	0.423			NA											13	74					0.00010058	0.000119439	0.001368	1	0
OR6Q1	219952	broad.mit.edu	37	11	57799060	57799060	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:57799060G>A	uc010rjz.1	+	1	636	c.636G>A	c.(634-636)CTG>CTA	p.L212L	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CTGTGCTACTGGCCTCCTCTA	0.547			NA											16	73					0	0	0.006122	0	0
TAF6L	10629	broad.mit.edu	37	11	62554190	62554190	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:62554190C>T	uc001nvc.2	+	11	1392	c.1291C>T	c.(1291-1293)CCT>TCT	p.P431S	TMEM179B_uc001nvd.3_5'Flank	NM_006473	NP_006464	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II	431					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			ovary(3)	3						GCCGGAGGACCCTTCTCTTTC	0.677			NA									OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	33					0	0	0.001984	0	0
MUS81	80198	broad.mit.edu	37	11	65631311	65631311	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:65631311A>T	uc001ofv.3	+	10	1351	c.998A>T	c.(997-999)GAG>GTG	p.E333V	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	333	ERCC4.			ER->AG: Loss of activity.	DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		CACATTGTGGAGCGCAAGCGA	0.607			NA						Homologous_recombination					24	92					0	0	0.001786	0	0
FAM181B	220382	broad.mit.edu	37	11	82443620	82443620	+	Silent	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:82443620C>G	uc001ozp.2	-	1	1287	c.1152G>C	c.(1150-1152)CCG>CCC	p.P384P		NM_175885	NP_787081	A6NEQ2	F181B_HUMAN	hypothetical protein LOC220382	384	Pro-rich.									large_intestine(1)	1						GCGGCGGCGGCGGGGGCAGGG	0.701			NA											2	13					0	0	0.004672	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106856830	106856830	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:106856830T>A	uc001pjg.1	-	2	721	c.331A>T	c.(331-333)AGG>TGG	p.R111W	GUCY1A2_uc010rvo.1_Missense_Mutation_p.R111W|GUCY1A2_uc009yxn.1_Missense_Mutation_p.R111W	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	111					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TGCAGTGTCCTCTTGAGAGTC	0.338			NA											15	75					0	0	0.004007	0	0
HTR3B	9177	broad.mit.edu	37	11	113803729	113803729	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:113803729G>A	uc001pok.2	+	6	677	c.610G>A	c.(610-612)GAC>AAC	p.D204N	HTR3B_uc001pol.2_Missense_Mutation_p.D193N	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	204	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GTTTTTGAATGACAGTGAGTG	0.453			NA											6	42					0	0	0.001168	0	0
DCPS	28960	broad.mit.edu	37	11	126174154	126174154	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:126174154A>T	uc001qdp.2	+	1	508	c.179A>T	c.(178-180)AAA>ATA	p.K60I		NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme	60					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		GCGCGGGACAAAATCATTTTC	0.537			NA											19	99					0	0	0.001882	0	0
FLI1	2313	broad.mit.edu	37	11	128680399	128680399	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:128680399C>T	uc010sbu.1	+	9	1216	c.875C>T	c.(874-876)TCC>TTC	p.S292F	FLI1_uc010sbt.1_Missense_Mutation_p.S99F|FLI1_uc010sbv.1_Missense_Mutation_p.S259F|FLI1_uc009zci.2_Missense_Mutation_p.S226F	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	292	ETS.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GAGCTGCTCTCCGACAGCGCC	0.627			NA	T	EWSR1	Ewing sarcoma								5	11					0	0	0.000602	0	0
BARX2	8538	broad.mit.edu	37	11	129246035	129246035	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:129246035C>A	uc001qfc.3	+	1	155	c.105C>A	c.(103-105)ACC>ACA	p.T35T		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	35											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CCAAGGAGACCTGCGATTACT	0.602			NA									OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	166					6.05902e-23	9.92425e-23	0.003755	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	33					0.000602214	0.000697687	0.000602	1	0
C12orf35	55196	broad.mit.edu	37	12	32134631	32134631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:32134631C>T	uc001rks.2	+	4	1156	c.742C>T	c.(742-744)CAG>TAG	p.Q248*		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	248										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TAAAAATAGTCAGCTTCTAAA	0.393			NA											6	60					0	0	0.001984	0	0
BICD1	636	broad.mit.edu	37	12	32458919	32458919	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:32458919C>T	uc001rku.2	+	4	949	c.868C>T	c.(868-870)CAT>TAT	p.H290Y	BICD1_uc001rkv.2_Missense_Mutation_p.H290Y|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	290					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CGGTCATATCCATGGGCCTCT	0.448			NA											5	51					0	0	0.001168	0	0
LRP1	4035	broad.mit.edu	37	12	57587439	57587439	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:57587439G>T	uc001snd.2	+	47	8241	c.7775G>T	c.(7774-7776)GGG>GTG	p.G2592V	MIR1228_hsa-mir-1228|MI0006318_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2592	Extracellular (Potential).|LDL-receptor class A 12.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGACTGTGGGGATGGCTCT	0.602			NA											25	78					2.61193e-14	3.97014e-14	0.001786	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85638600	85638600	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:85638600G>C	uc001tac.2	+	27	5161	c.5050G>C	c.(5050-5052)GAC>CAC	p.D1684H		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1684										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CACGGATTTAGACCTTTTTTC	0.398			NA											15	79					0	0	0.001523	0	0
ANKS1B	56899	broad.mit.edu	37	12	100048885	100048885	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:100048885C>A	uc001tge.1	-	9	1649	c.1232G>T	c.(1231-1233)TGT>TTT	p.C411F	ANKS1B_uc001tgf.1_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.C377F	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	411						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ACATCCATTACACGGAGTTAA	0.403			NA											9	45					7.03913e-09	9.76229e-09	0.001368	1	0
SFRS8	6433	broad.mit.edu	37	12	132281798	132281798	+	Silent	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:132281798A>G	uc001uja.1	+	16	2750	c.2610A>G	c.(2608-2610)TCA>TCG	p.S870S	SFRS8_uc010tbn.1_Silent_p.S922S	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	870	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		AGTCGGTGTCACCCAGCAAGC	0.532			NA											16	77					0	0	0.004007	0	0
NALCN	259232	broad.mit.edu	37	13	101712256	101712256	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr13:101712256G>A	uc001vox.1	-	42	5008	c.4819C>T	c.(4819-4821)CGG>TGG	p.R1607W		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1607	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTCAGAAACCGGCTCAGCTCT	0.532			NA											8	133					0	0	0.004482	0	0
SUPT16H	11198	broad.mit.edu	37	14	21836475	21836475	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:21836475T>G	uc001wao.2	-	7	1247	c.908A>C	c.(907-909)AAC>ACC	p.N303T		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	303					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GAGCAAAAAGTTATAATTTTC	0.403			NA											10	67					0	0	0.000978	0	0
CHD8	57680	broad.mit.edu	37	14	21873479	21873479	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:21873479C>A	uc001was.1	-	16	2453	c.2359G>T	c.(2359-2361)GAG>TAG	p.E787*	CHD8_uc001war.1_Nonsense_Mutation_p.E683*|CHD8_uc001wav.1_Nonsense_Mutation_p.E229*	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1066					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AAATTCTTCTCCAAAATAGCC	0.408			NA											5	14					8.12818e-05	9.7744e-05	0.001984	1	0
SIX6	4990	broad.mit.edu	37	14	60976318	60976318	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:60976318C>A	uc001xfa.3	+	1	381	c.202C>A	c.(202-204)CGC>AGC	p.R68S		NM_007374	NP_031400	O95475	SIX6_HUMAN	SIX homeobox 6	68					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.088)		TGGCAACTACCGCGAGCTCTA	0.607			NA											6	22					3.59834e-05	4.35467e-05	0.001168	1	0
SETD3	84193	broad.mit.edu	37	14	99871602	99871602	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:99871602C>A	uc001ygc.2	-	10	1201	c.1031G>T	c.(1030-1032)AGT>ATT	p.S344I		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	344					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GTCACTTTTACTCACTCCAAG	0.463			NA											26	85					7.33532e-06	9.2914e-06	0.003954	1	0
TRPM1	4308	broad.mit.edu	37	15	31294305	31294305	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:31294305A>T	uc001zfm.2	-	27	4660	c.4532T>A	c.(4531-4533)GTC>GAC	p.V1511D	TRPM1_uc010azy.2_Missense_Mutation_p.V1418D|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1511	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TGCTTCAGCGACATGGTGTTC	0.458			NA											12	311					0	0	0.001855	0	0
SIN3A	25942	broad.mit.edu	37	15	75694265	75694265	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:75694265C>A	uc002bai.2	-	10	1713	c.1454G>T	c.(1453-1455)CGC>CTC	p.R485L	SIN3A_uc002baj.2_Missense_Mutation_p.R485L|SIN3A_uc010uml.1_Missense_Mutation_p.R485L	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	485	PAH 3.|Interaction with SAP30 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						AACAAGACAGCGTAGGAAATT	0.463			NA											3	67					0.004672	0.00531545	0.004672	1	0
IL16	3603	broad.mit.edu	37	15	81593853	81593853	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:81593853G>T	uc002bgh.3	+	15	3694	c.3318G>T	c.(3316-3318)AAG>AAT	p.K1106N	IL16_uc010blq.1_Missense_Mutation_p.K1060N|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.K1148N|IL16_uc002bgg.2_Missense_Mutation_p.K1106N|IL16_uc002bgi.1_Missense_Mutation_p.K496N|IL16_uc002bgj.2_Missense_Mutation_p.K600N|IL16_uc002bgk.2_Missense_Mutation_p.K405N|IL16_uc002bgl.1_Missense_Mutation_p.K405N|IL16_uc010unq.1_Missense_Mutation_p.K405N	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1106	Interaction with HTLV-1 tax.|Interaction with PPP1R12A, PPP1R12B and PPP1R12C.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CAACATTAAAGGTAGGTTTCC	0.473			NA											9	52					3.07112e-06	3.94265e-06	0.000978	1	0
FANCI	55215	broad.mit.edu	37	15	89857858	89857858	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:89857858G>A	uc010bnp.1	+	36	3826	c.3736G>A	c.(3736-3738)GAA>AAA	p.E1246K	FANCI_uc002bnm.1_Missense_Mutation_p.E1186K|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.E1006K|FANCI_uc002bnq.1_Missense_Mutation_p.E659K	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1246					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AGTTCTTCGGGAAACCAAGCC	0.373			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				3	75					0	0	0.000248	0	0
PKD1	5310	broad.mit.edu	37	16	2160351	2160351	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:2160351G>A	uc002cos.1	-	15	5026	c.4817C>T	c.(4816-4818)ACC>ATC	p.T1606I	PKD1_uc002cot.1_Missense_Mutation_p.T1606I	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1606	PKD 11.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GATATTGAAGGTGCCCACGGA	0.617			NA											3	74					0	0	0.000248	0	0
NAT15	79903	broad.mit.edu	37	16	3533551	3533551	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:3533551A>G	uc002cvh.3	+	6	772	c.526A>G	c.(526-528)ACC>GCC	p.T176A	NAT15_uc010uxb.1_Missense_Mutation_p.T183A|NAT15_uc010btk.1_Missense_Mutation_p.T111A|NAT15_uc010btl.2_Intron|NAT15_uc010btm.2_Missense_Mutation_p.T176A|NAT15_uc010uxc.1_Missense_Mutation_p.T176A|NAT15_uc010uxd.1_Intron|NAT15_uc010uxe.1_Intron|NAT15_uc002cvg.1_Missense_Mutation_p.T176A	NM_001083601	NP_001077070	Q9H7X0	NAT15_HUMAN	N-acetyltransferase 15	176	N-acetyltransferase.						N-acetyltransferase activity				0						AGATGGCTTCACCTATGTCCT	0.488			NA											6	65					0	0	0.004482	0	0
TXNDC11	51061	broad.mit.edu	37	16	11785454	11785454	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:11785454G>A	uc010buu.1	-	9	1735	c.1673C>T	c.(1672-1674)ACT>ATT	p.T558I	TXNDC11_uc002dbg.1_Missense_Mutation_p.T531I	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	558					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						AAATGCAACAGTAGGGGCTTC	0.488			NA											4	133					0	0	0.000602	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926638	22926638	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:22926638C>A	uc002dli.2	+	2	931	c.859C>A	c.(859-861)CGA>AGA	p.R287R	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	287	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		CGAGATGGGGCGAGTCCAGGA	0.532			NA											28	218					1.08312e-15	1.67311e-15	0.001786	1	0
ERN2	10595	broad.mit.edu	37	16	23702633	23702633	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:23702633C>T	uc002dma.3	-	20	2803	c.2634G>A	c.(2632-2634)CCG>CCA	p.P878P	ERN2_uc010bxp.2_Silent_p.P826P	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	830	KEN.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGTCTGCAGCGGCATGGAGA	0.672			NA											3	51					0	0	0.000248	0	0
EIF3CL	728689	broad.mit.edu	37	16	28734627	28734627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:28734627G>T	uc010byj.2	+	10	1011	c.922G>T	c.(922-924)GGA>TGA	p.G308*	uc010vct.1_Intron|EIF3CL_uc010byi.2_Nonsense_Mutation_p.G307*|EIF3CL_uc002dqs.3_Nonsense_Mutation_p.G307*|EIF3C_uc002dqt.3_Nonsense_Mutation_p.G307*|EIF3CL_uc010vcy.1_Nonsense_Mutation_p.G297*|EIF3C_uc002dqu.3_Nonsense_Mutation_p.G307*|EIF3CL_uc002dqv.3_Nonsense_Mutation_p.G53*	NM_001099661	NP_001093131	B5ME19	B5ME19_HUMAN	eukaryotic translation initiation factor 3,	308						eukaryotic translation initiation factor 3 complex	translation initiation factor activity				0						GGTCCGGGGCGGAGTGCCGTT	0.542			NA											37	492					1.38909e-20	2.2558e-20	0.00361	1	0
ORAI3	93129	broad.mit.edu	37	16	30964750	30964750	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:30964750G>C	uc002eac.2	+	2	679	c.473G>C	c.(472-474)GGC>GCC	p.G158A		NM_152288	NP_689501	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator	158	Helical; (Potential).					integral to membrane	protein binding				0						ACTGCCCTGGGCACCTTTCTC	0.597			NA									OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	140					0	0	0.008361	0	0
ZNF668	79759	broad.mit.edu	37	16	31073432	31073432	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:31073432T>A	uc010caf.2	-	3	1174	c.817A>T	c.(817-819)ACG>TCG	p.T273S	ZNF668_uc002eao.2_Missense_Mutation_p.T273S	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	273	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						CCCGAGTGCGTGCGCTCGTGG	0.692	Colon(181;1111 1980 5060 10512 25785)		NA											5	59					0	0	0.001168	0	0
SHCBP1	79801	broad.mit.edu	37	16	46649880	46649880	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:46649880C>A	uc002eec.3	-	4	614	c.574G>T	c.(574-576)GCC>TCC	p.A192S		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	192										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				ATTGCAAGGGCTGTCTGGTCA	0.463			NA											26	181					9.65021e-13	1.42135e-12	0.002096	1	0
CDH8	1006	broad.mit.edu	37	16	61689518	61689518	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:61689518T>A	uc002eog.1	-	11	2014	c.1762A>T	c.(1762-1764)AGC>TGC	p.S588C		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	588	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTGCTAGTGCTGCTCAGTGGA	0.453			NA											14	77					0	0	0.006122	0	0
FAM65A	79567	broad.mit.edu	37	16	67579635	67579635	+	Missense_Mutation	SNP	G	G	A	rs139937481		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:67579635G>A	uc010vjp.1	+	19	3415	c.3319G>A	c.(3319-3321)GAG>AAG	p.E1107K	FAM65A_uc002eth.2_Missense_Mutation_p.E1087K|FAM65A_uc010cej.2_Missense_Mutation_p.E1090K|FAM65A_uc010vjq.1_Missense_Mutation_p.E1101K|FAM65A_uc002etk.2_Missense_Mutation_p.E1085K	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	1091						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		ATTGGCGCCCGAGGGGCGTCT	0.622			NA											8	95					0	0	0.00308	0	0
HYDIN	54768	broad.mit.edu	37	16	70889125	70889125	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:70889125C>G	uc002ezr.2	-	73	12474	c.12346G>C	c.(12346-12348)GAT>CAT	p.D4116H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4117										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AAGGAAAAATCGAACCCCTGC	0.547			NA											3	110					0	0	0.000602	0	0
MPRIP	23164	broad.mit.edu	37	17	17057722	17057722	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:17057722G>T	uc002gqu.1	+	13	1524	c.1468G>T	c.(1468-1470)GTG>TTG	p.V490L	MPRIP_uc002gqv.1_Missense_Mutation_p.V490L|MPRIP_uc002gqw.1_Missense_Mutation_p.V245L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	490						cytoplasm|cytoskeleton	actin binding				0						TGCCCCGGATGTGACCAGGTA	0.592			NA											12	60					6.31663e-08	8.63424e-08	0.003163	1	0
MYO15A	51168	broad.mit.edu	37	17	18023545	18023545	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:18023545C>A	uc010vxh.1	+	2	1769	c.1431C>A	c.(1429-1431)TTC>TTA	p.F477L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	477	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TCCGCAAGTTCCGCCTCTTCC	0.647			NA											19	35					1.55795e-14	2.38718e-14	0.001882	1	0
SLC13A2	9058	broad.mit.edu	37	17	26822805	26822805	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:26822805A>G	uc002hbh.2	+	10	1508	c.1441A>G	c.(1441-1443)ACG>GCG	p.T481A	SLC13A2_uc010wam.1_Missense_Mutation_p.T437A|SLC13A2_uc010wan.1_Missense_Mutation_p.T530A|SLC13A2_uc010wao.1_Missense_Mutation_p.T438A|SLC13A2_uc002hbi.2_Missense_Mutation_p.T410A	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	481						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GGCCACCACTACGATCTTCCT	0.637			NA											29	185					0	0	0.004878	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27939023	27939023	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:27939023A>G	uc002hei.2	+	10	1212	c.1099A>G	c.(1099-1101)AAG>GAG	p.K367E	ANKRD13B_uc002heh.2_Missense_Mutation_p.K235E|ANKRD13B_uc002hej.2_RNA|ANKRD13B_uc002hek.2_5'Flank	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	367											0						CAAGACACAGAAGTGAGGCCC	0.612			NA											7	45					0	0	0.004482	0	0
PTPRM	5797	broad.mit.edu	37	18	8384599	8384599	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:8384599A>T	uc002knn.3	+	28	4423	c.3920A>T	c.(3919-3921)CAC>CTC	p.H1307L	PTPRM_uc010dkv.2_Missense_Mutation_p.H1320L|PTPRM_uc010wzl.1_Missense_Mutation_p.H1094L	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1307	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GTACACAGACACGGCCCCATC	0.453			NA											19	87					0	0	0.002299	0	0
KIAA1632	57724	broad.mit.edu	37	18	43437840	43437840	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:43437840G>A	uc002lbm.2	-	42	7520	c.7420C>T	c.(7420-7422)CGG>TGG	p.R2474W	KIAA1632_uc010xcq.1_Missense_Mutation_p.R1028W|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.R1349W	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2474					autophagy						0						GGCGACTTCCGGCCAAACCCA	0.488			NA											13	63					0	0	0.004007	0	0
NEDD4L	23327	broad.mit.edu	37	18	55996235	55996235	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:55996235C>T	uc002lgy.2	+	10	963	c.689C>T	c.(688-690)TCC>TTC	p.S230F	NEDD4L_uc002lgz.2_Missense_Mutation_p.S230F|NEDD4L_uc002lgx.2_Missense_Mutation_p.S230F|NEDD4L_uc010xee.1_Missense_Mutation_p.S109F|NEDD4L_uc002lhc.2_Missense_Mutation_p.S222F|NEDD4L_uc002lhd.2_Missense_Mutation_p.S109F|NEDD4L_uc002lhb.2_Missense_Mutation_p.S109F|NEDD4L_uc002lhe.2_Missense_Mutation_p.S222F|NEDD4L_uc002lhf.2_Missense_Mutation_p.S109F|NEDD4L_uc002lhg.2_Missense_Mutation_p.S109F|NEDD4L_uc002lhh.2_Missense_Mutation_p.S109F|NEDD4L_uc010dpm.1_Missense_Mutation_p.S81F	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	230					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						AGGGACGTGTCCTCGGAGTCG	0.587			NA											5	65					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9087070	9087070	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:9087070G>T	uc002mkp.2	-	1	4949	c.4745C>A	c.(4744-4746)TCC>TAC	p.S1582Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1582	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGGGAAGGGGATGCTGAGGC	0.498			NA											23	209					2.27525e-19	3.63276e-19	0.003954	1	0
BEST2	54831	broad.mit.edu	37	19	12867072	12867072	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:12867072C>T	uc002mux.2	+	8	1066	c.1066C>T	c.(1066-1068)CGG>TGG	p.R356W		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	356	Cytoplasmic (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						CTTCCAGCTGCGGCAGCCTTC	0.627			NA											10	199					0	0	0.000978	0	0
CYP4F3	4051	broad.mit.edu	37	19	15769110	15769110	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:15769110C>T	uc002nbj.2	+	10	1202	c.1152C>T	c.(1150-1152)TGC>TGT	p.C384C	CYP4F3_uc010xok.1_Silent_p.C384C|CYP4F3_uc010xol.1_Silent_p.C384C|CYP4F3_uc010xom.1_Silent_p.C235C|CYP4F3_uc002nbk.2_Silent_p.C384C|CYP4F3_uc010xon.1_Silent_p.C94C	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	384					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TGACCATGTGCATTAAGGAGA	0.592			NA											17	122					0	0	0.006122	0	0
C19orf44	84167	broad.mit.edu	37	19	16612013	16612013	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:16612013G>T	uc002neh.1	+	2	483	c.410G>T	c.(409-411)GGG>GTG	p.G137V	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.G137V|C19orf44_uc002neg.2_Missense_Mutation_p.G137V|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	137											0						ATCCTCTCTGGGGGTGCACTC	0.507			NA											12	60					1.05317e-09	1.48224e-09	0.00245	1	0
PBX4	80714	broad.mit.edu	37	19	19681537	19681537	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:19681537C>A	uc002nmy.2	-	3	300	c.299G>T	c.(298-300)GGA>GTA	p.G100V	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_5'UTR	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	100							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						TCCTCCTCTTCCTCTCTTCTC	0.602			NA											9	53					1.12685e-05	1.39936e-05	0.004482	1	0
ZNF98	148198	broad.mit.edu	37	19	22585642	22585642	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:22585642C>A	uc002nqt.2	-	3	324	c.202G>T	c.(202-204)GGA>TGA	p.G68*		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGTTCTTTTCCTTGCTCCAGA	0.423			NA											18	99					3.32936e-07	4.3929e-07	0.006122	1	0
UPK1A	11045	broad.mit.edu	37	19	36159410	36159410	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:36159410C>T	uc002oaw.2	+	2	139	c.139C>T	c.(139-141)CGT>TGT	p.R47C	UPK1A_uc010eeh.2_Missense_Mutation_p.R47C|uc002oax.1_Missense_Mutation_p.R46Q	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	47	Extracellular (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGACCAGTACCGTGTATACCC	0.577			NA											8	96					0	0	0.006214	0	0
PSENEN	55851	broad.mit.edu	37	19	36237385	36237385	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:36237385C>G	uc002obi.1	+	3	331	c.127C>G	c.(127-129)CTT>GTT	p.L43V	TMEM149_uc010eej.2_5'Flank|U2AF1L4_uc002obh.1_5'Flank|U2AF1L4_uc002obe.2_5'Flank|U2AF1L4_uc002obf.2_5'Flank|U2AF1L4_uc002obg.2_5'Flank|PSENEN_uc002obj.1_Missense_Mutation_p.L43V|PSENEN_uc002obk.1_RNA|LIN37_uc002obm.2_5'Flank	NM_172341	NP_758844	Q9NZ42	PEN2_HUMAN	presenilin enhancer 2	43	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	aspartic-type endopeptidase activity|protein binding			ovary(2)	2	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAGGCCTTCCTTGTCCCAGC	0.527			NA											15	128					0	0	0.008871	0	0
RYR1	6261	broad.mit.edu	37	19	39034259	39034259	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:39034259G>T	uc002oit.2	+	86	11996	c.11866G>T	c.(11866-11868)GTG>TTG	p.V3956L	RYR1_uc002oiu.2_Missense_Mutation_p.V3951L|RYR1_uc002oiv.1_Missense_Mutation_p.V865L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3956					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCCATGTCGGTGGCTAAGCA	0.597			NA											17	105					5.3912e-06	6.87469e-06	0.006122	1	0
ZNF534	147658	broad.mit.edu	37	19	52941209	52941209	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:52941209G>T	uc002pzk.2	+	4	596	c.535G>T	c.(535-537)GAT>TAT	p.D179Y	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.D166Y	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACAGAAATGATTTTCTTTT	0.333			NA											7	52					1.12685e-05	1.39936e-05	0.004482	1	0
CACNG8	59283	broad.mit.edu	37	19	54483188	54483188	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:54483188C>A	uc002qcs.1	+	3	538	c.432C>A	c.(430-432)TGC>TGA	p.C144*	MIR935_hsa-mir-935|MI0005757_5'Flank	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	145	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GGGGTGTGTGCGTGGCGGCCT	0.642			NA											11	28					0.00010058	0.000119439	0.001368	1	0
LILRB5	10990	broad.mit.edu	37	19	54760503	54760503	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:54760503G>T	uc002qex.2	-	3	315	c.204C>A	c.(202-204)GCC>GCA	p.A68A	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.A68A|LILRB5_uc002qey.2_Silent_p.A68A|LILRB5_uc002qez.2_Silent_p.A68A|LILRB5_uc002qfa.1_Silent_p.A58A|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	68	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCTCTTCCGGGCCCATGGGA	0.602			NA											33	189					1.30998e-17	2.057e-17	0.005524	1	0
SH3YL1	26751	broad.mit.edu	37	2	233146	233146	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:233146G>C	uc002qvx.2	-	6	572	c.488C>G	c.(487-489)TCT>TGT	p.S163C	SH3YL1_uc002qvy.2_Missense_Mutation_p.S163C|SH3YL1_uc002qvz.2_RNA|SH3YL1_uc002qwa.2_RNA|SH3YL1_uc010ewe.2_Missense_Mutation_p.S67C|SH3YL1_uc002qvu.2_RNA|SH3YL1_uc002qvv.2_Missense_Mutation_p.S67C|SH3YL1_uc002qvw.2_RNA	NM_015677	NP_056492	Q96HL8	SH3Y1_HUMAN	SH3 domain containing, Ysc84-like 1 isoform 1	163										ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		CCCTTCTAAAGACACGCCTGC	0.423			NA											6	38					0	0	0.006214	0	0
PLB1	151056	broad.mit.edu	37	2	28840597	28840597	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:28840597T>G	uc002rmb.1	+	45	3199	c.3199T>G	c.(3199-3201)TGG>GGG	p.W1067G	PLB1_uc010ezj.1_Missense_Mutation_p.W1056G|PLB1_uc002rme.1_Missense_Mutation_p.W32G|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	1067	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|4.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GATTTAGAACTGGGGCAGTGA	0.463			NA											25	99					0	0	0.002445	0	0
ATOH8	84913	broad.mit.edu	37	2	85981354	85981354	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:85981354C>T	uc002sqn.2	+	1	446	c.42C>T	c.(40-42)ACC>ACT	p.T14T	ATOH8_uc002sqm.3_Silent_p.T14T	NM_032827	NP_116216	Q96SQ7	ATOH8_HUMAN	atonal homolog 8	14					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CGTGGAAGACCGTGTGCGTGA	0.443			NA											4	16					0	0	0.001168	0	0
TBC1D8	11138	broad.mit.edu	37	2	101706815	101706815	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:101706815C>G	uc010fiv.2	-	2	270	c.139G>C	c.(139-141)GGC>CGC	p.G47R	TBC1D8_uc010yvw.1_Missense_Mutation_p.G47R	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	47					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						TCCAGAGCGCCGACCAGGCGA	0.547			NA											7	45					0	0	0.00308	0	0
LRP1B	53353	broad.mit.edu	37	2	141299476	141299476	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:141299476C>T	uc002tvj.1	-	44	8231	c.7259G>A	c.(7258-7260)TGG>TAG	p.W2420*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2420	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAGTCCGACCAGAATATATA	0.388	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	62					0	0	0.00245	0	0
SCN7A	6332	broad.mit.edu	37	2	167262236	167262236	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:167262236C>A	uc002udu.1	-	25	5030	c.4903G>T	c.(4903-4905)GCT>TCT	p.A1635S		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1635					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TTTTTATAAGCACGTTGAATG	0.378			NA											15	109					1.3612e-06	1.77143e-06	0.003163	1	0
MDH1B	130752	broad.mit.edu	37	2	207621963	207621963	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:207621963G>C	uc002vbs.2	-	3	323	c.268C>G	c.(268-270)CAG>GAG	p.Q90E	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.Q90E|MDH1B_uc010fuj.2_5'UTR|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	90					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTATATACCTGAGCATGCTCC	0.368	Pancreas(76;29 1355 28675 37177 51207)		NA											20	87					0	0	0.00278	0	0
DES	1674	broad.mit.edu	37	2	220286087	220286087	+	Missense_Mutation	SNP	G	G	T	rs57965306		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:220286087G>T	uc002vll.2	+	6	1135	c.1049G>T	c.(1048-1050)CGG>CTG	p.R350L		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	350	Rod.|Coil 2B.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGGCAGATGCGGGAATTGGAG	0.587			NA											7	64					3.09899e-07	4.11753e-07	0.004482	1	0
STK11IP	114790	broad.mit.edu	37	2	220473352	220473352	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:220473352G>C	uc002vml.2	+	15	1727	c.1684G>C	c.(1684-1686)GGC>CGC	p.G562R	STK11IP_uc010zll.1_Missense_Mutation_p.G519R|STK11IP_uc002vmm.1_Missense_Mutation_p.G551R	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	562	Glu-rich.				protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGCCTGAGGGCGTACGGGG	0.602			NA											6	56					0	0	0.001984	0	0
INPP5D	3635	broad.mit.edu	37	2	233995347	233995347	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:233995347G>A	uc010zmo.1	+	5	807	c.654G>A	c.(652-654)AAG>AAA	p.K218K	INPP5D_uc010zmp.1_Silent_p.K217K	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	218					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TGCTCTGCAAGGAGCTCTATG	0.577	NSCLC(82;1215 1426 16163 20348 41018)		NA											4	38					0	0	0.001168	0	0
ANKMY1	51281	broad.mit.edu	37	2	241465684	241465685	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:241465684_241465685CC>AA	uc002vyz.1	-	5	1093_1094	c.864_865GG>TT	c.(862-867)GTGGCG>GTTTCG	p.A289S	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Missense_Mutation_p.A378S|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	289							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTTGCGTCCGCCACGTCAGCAC	0.554			NA											7	90					0	0	0.004672	0	0
PLCB1	23236	broad.mit.edu	37	20	8703032	8703032	+	Silent	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr20:8703032T>C	uc002wnb.2	+	15	1548	c.1545T>C	c.(1543-1545)GAT>GAC	p.D515D	PLCB1_uc010zrb.1_Silent_p.D414D|PLCB1_uc002wna.2_Silent_p.D515D|PLCB1_uc002wnc.1_Silent_p.D414D|PLCB1_uc002wnd.1_Silent_p.D92D	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	515					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ACGACGACGATGATGATGATG	0.423			NA											3	87					0	0	0.004672	0	0
TTC3	7267	broad.mit.edu	37	21	38459593	38459593	+	Silent	SNP	G	G	T	rs73201925	by1000genomes	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr21:38459593G>T	uc002yvz.2	+	2	141	c.36G>T	c.(34-36)GCG>GCT	p.A12A	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Silent_p.A12A|TTC3_uc002ywb.2_Silent_p.A12A|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Silent_p.A12A	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	12					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TCACTGTGGCGGATTATGCCT	0.403	Ovarian(38;194 1649 35661)		NA											39	233					2.42038e-35	3.9989e-35	0.007835	1	0
AP1B1	162	broad.mit.edu	37	22	29754807	29754807	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr22:29754807C>A	uc003afj.2	-	5	617	c.433G>T	c.(433-435)GTG>TTG	p.V145L	AP1B1_uc003afi.2_Missense_Mutation_p.V145L|AP1B1_uc003afk.2_Missense_Mutation_p.V145L|AP1B1_uc003afl.2_Missense_Mutation_p.V145L	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	145					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						AGCTTGGCCACGCACACAGCT	0.577			NA											7	48					2.17888e-05	2.68823e-05	0.006214	1	0
CELSR1	9620	broad.mit.edu	37	22	46780486	46780486	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr22:46780486G>A	uc003bhw.1	-	20	6837	c.6837C>T	c.(6835-6837)TCC>TCT	p.S2279S	CELSR1_uc011arc.1_Silent_p.S600S	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2279	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGGAGACGGAGGACTCCAGCT	0.552			NA											8	24					0	0	0.00308	0	0
ITPR1	3708	broad.mit.edu	37	3	4558210	4558210	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:4558210G>T	uc003bqa.2	+	3	383	c.35G>T	c.(34-36)GGA>GTA	p.G12V	ITPR1_uc010hbz.2_Missense_Mutation_p.G12V|ITPR1_uc010hca.1_Missense_Mutation_p.G12V|ITPR1_uc011asu.1_Missense_Mutation_p.G12V|ITPR1_uc010hcb.1_Missense_Mutation_p.G12V	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	12	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTACATATTGGAGACATTTGT	0.383			NA											10	117					2.80697e-09	3.92151e-09	0.000978	1	0
SLC25A38	54977	broad.mit.edu	37	3	39432934	39432934	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:39432934C>T	uc003cjo.2	+	4	680	c.279C>T	c.(277-279)TCC>TCT	p.S93S		NM_017875	NP_060345	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	93	Solcar 1.|Helical; Name=2; (Potential).				erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTCTGCAGTCCATTGTGAGAT	0.368			NA											78	544					0	0	0.00361	0	0
GPR27	2850	broad.mit.edu	37	3	71804119	71804119	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:71804119C>T	uc011bge.1	+	1	919	c.919C>T	c.(919-921)CGG>TGG	p.R307W	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	307	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CAGCTACCTGCGGGTCCTGGT	0.662			NA											5	44					0	0	0.000602	0	0
GOLGB1	2804	broad.mit.edu	37	3	121383793	121383793	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:121383793T>G	uc003eei.3	-	21	9751	c.9625A>C	c.(9625-9627)ACA>CCA	p.T3209P	GOLGB1_uc010hrc.2_Missense_Mutation_p.T3219P|GOLGB1_uc003eej.3_Missense_Mutation_p.T3175P	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3209	Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CTGTTGCTTGTAAGATCTATT	0.478			NA											8	66					0	0	0.006214	0	0
IL12A	3592	broad.mit.edu	37	3	159713204	159713204	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:159713204A>G	uc003fcx.2	+	7	835	c.620A>G	c.(619-621)AAC>AGC	p.N207S	uc003fcw.1_Intron	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	173					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTGAATTTCAACAGTGAGACT	0.373			NA											8	74					0	0	0.004482	0	0
LPHN3	23284	broad.mit.edu	37	4	62800699	62800699	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:62800699C>G	uc010ihh.2	+	11	2223	c.2050C>G	c.(2050-2052)CTT>GTT	p.L684V	LPHN3_uc003hcq.3_Missense_Mutation_p.L684V|LPHN3_uc003hct.2_Missense_Mutation_p.L77V|LPHN3_uc003hcs.1_Missense_Mutation_p.L500V	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	671	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GGCTGATAACCTTTTGAAGAC	0.443			NA											5	60					0	0	0.001168	0	0
PDLIM5	10611	broad.mit.edu	37	4	95585159	95585159	+	Missense_Mutation	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:95585159T>C	uc003hti.2	+	13	1883	c.1732T>C	c.(1732-1734)TTT>CTT	p.F578L	PDLIM5_uc011cdx.1_Missense_Mutation_p.F475L|PDLIM5_uc003hth.2_Missense_Mutation_p.F469L|PDLIM5_uc003htj.2_Missense_Mutation_p.F253L|PDLIM5_uc003htk.2_Missense_Mutation_p.F607L|PDLIM5_uc011cdy.1_Missense_Mutation_p.F456L|PDLIM5_uc003htl.2_Missense_Mutation_p.F253L	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	578	LIM zinc-binding 3.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		AGGTCAGACCTTTTTCTCCAA	0.373			NA											3	100					0	0	0.000248	0	0
FAT4	79633	broad.mit.edu	37	4	126372962	126372962	+	Silent	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:126372962A>T	uc003ifj.3	+	9	10791	c.10791A>T	c.(10789-10791)ACA>ACT	p.T3597T	FAT4_uc011cgp.1_Silent_p.T1895T|FAT4_uc003ifi.1_Silent_p.T1075T	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3597	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTCTTCCACAGGAACTGTGC	0.428			NA											20	106					0	0	0.003954	0	0
SLC9A3	6550	broad.mit.edu	37	5	491958	491958	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:491958G>A	uc003jbe.2	-	2	552	c.440C>T	c.(439-441)GCC>GTC	p.A147V	SLC9A3_uc011clx.1_Missense_Mutation_p.A147V	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	147	Helical; Name=E/M5; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACCCACGACGGCGTACAACAG	0.642			NA											6	15					0	0	0.001168	0	0
PRDM9	56979	broad.mit.edu	37	5	23527167	23527167	+	Missense_Mutation	SNP	G	G	C	rs112679149		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:23527167G>C	uc003jgo.2	+	11	2152	c.1970G>C	c.(1969-1971)AGA>ACA	p.R657T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	657	C2H2-type 6.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CACCAGAGGAGACACACAGGG	0.607			NA								HNSCC(3;0.000094)			5	96					0	0	0.000602	0	0
PLK2	10769	broad.mit.edu	37	5	57750850	57750850	+	Splice_Site	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:57750850T>C	uc003jrn.2	-	13	1883	c.1756_splice	c.e13-1	p.G586_splice		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2						positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ATCTCCACCCTGGAAGAGATT	0.358			NA											16	103					0	0	0.00499	0	0
TGFBI	7045	broad.mit.edu	37	5	135382099	135382099	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:135382099C>T	uc003lbf.3	+	4	535	c.374C>T	c.(373-375)ACG>ATG	p.T125M	TGFBI_uc003lbg.3_Translation_Start_Site|TGFBI_uc003lbh.3_Translation_Start_Site|TGFBI_uc011cyb.1_Translation_Start_Site	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	125	FAS1 1.		Missing (associated with Leu-124 in atypical granular dystrophy; French granular variant).		angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACGGACCGCACGGAGAAGCTG	0.612			NA											3	60					0	0	0.004672	0	0
CDC25C	995	broad.mit.edu	37	5	137622942	137622942	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:137622942C>A	uc003lcp.1	-	11	1213	c.942G>T	c.(940-942)CTG>CTT	p.L314L	CDC25C_uc003lcq.1_Silent_p.L241L|CDC25C_uc003lcr.1_Silent_p.L314L|CDC25C_uc011cyp.1_Silent_p.L331L|CDC25C_uc003lcs.1_Silent_p.L392L	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	314					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTTCCCCGACAGTAAGGCAG	0.468			NA											7	78					5.68852e-11	8.25053e-11	0.004482	1	0
FAM71B	153745	broad.mit.edu	37	5	156589684	156589684	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:156589684G>T	uc003lwn.2	-	2	1692	c.1592C>A	c.(1591-1593)GCC>GAC	p.A531D		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	531						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATCTTACTGGCTTTCTTTTG	0.473			NA											13	44					1.5842e-08	2.18115e-08	0.001855	1	0
STK10	6793	broad.mit.edu	37	5	171520788	171520788	+	Silent	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:171520788T>G	uc003mbo.1	-	9	1482	c.1182A>C	c.(1180-1182)CCA>CCC	p.P394P		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	394							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGGCCACGACTGGGGGACTGG	0.632			NA											10	75					0	0	0.000978	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948601	2948601	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:2948601G>A	uc003muk.2	-	6	3057	c.1062C>T	c.(1060-1062)CCC>CCT	p.P354P	SERPINB6_uc003mui.2_Silent_p.P237P|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Silent_p.P354P|SERPINB6_uc003mum.2_Silent_p.P354P|SERPINB6_uc003mun.2_Silent_p.P354P|SERPINB6_uc003muo.2_Silent_p.P354P	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	354					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGAAAAGGAAGGGGTGGTCGG	0.602			NA											3	38					0	0	0.004672	0	0
PPT2	9374	broad.mit.edu	37	6	32122466	32122466	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:32122466A>G	uc003nzx.2	+	2	663	c.95A>G	c.(94-96)CAC>CGC	p.H32R	PRRT1_uc003nzs.2_5'Flank|PRRT1_uc003nzt.2_5'Flank|PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Missense_Mutation_p.H38R|PPT2_uc011dpi.1_RNA|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.H32R|PPT2_uc003oaa.2_Missense_Mutation_p.H32R|PPT2_uc010jtu.1_Missense_Mutation_p.H32R	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	32					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						CCCGCGCCCCACCGCGCGTCC	0.672			NA											7	66					0	0	0.001984	0	0
PACSIN1	29993	broad.mit.edu	37	6	34499392	34499392	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:34499392C>G	uc003ojo.2	+	9	1259	c.1053C>G	c.(1051-1053)GAC>GAG	p.D351E	PACSIN1_uc003ojp.2_Missense_Mutation_p.D351E	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	351					endocytosis		protein kinase activity				0						GCAGCTACGACAGAGGCCAGC	0.622			NA											11	138					0	0	0.001855	0	0
ASCC3	10973	broad.mit.edu	37	6	100965873	100965873	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:100965873A>G	uc003pqk.2	-	38	6250	c.5921T>C	c.(5920-5922)CTT>CCT	p.L1974P		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTACTTGAAAAGGTGAAGATG	0.308			NA											3	79					0	0	0.004672	0	0
AIM1	202	broad.mit.edu	37	6	106967686	106967686	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:106967686C>T	uc003prh.2	+	2	1866	c.1379C>T	c.(1378-1380)TCA>TTA	p.S460L		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	460							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CCTGCTGAGTCATCTCCTGGG	0.512			NA											9	108					0	0	0.000978	0	0
PTPRK	5796	broad.mit.edu	37	6	128643394	128643394	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:128643394C>A	uc003qbk.2	-	3	652	c.285G>T	c.(283-285)CTG>CTT	p.L95L	PTPRK_uc003qbj.2_Silent_p.L95L|PTPRK_uc010kfc.2_Silent_p.L95L|PTPRK_uc011ebu.1_Silent_p.L95L|PTPRK_uc003qbl.1_Intron|PTPRK_uc011ebv.1_Silent_p.L95L|PTPRK_uc003qbm.3_Silent_p.L24L	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	95	Extracellular (Potential).|MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCATTGTAGGCAGCTGAAGTC	0.388			NA											11	128					4.3838e-07	5.74429e-07	0.001855	1	0
VNN2	8875	broad.mit.edu	37	6	133078815	133078815	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:133078815C>T	uc003qdt.2	-	1	219	c.208G>A	c.(208-210)GAG>AAG	p.E70K	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Missense_Mutation_p.E70K|VNN2_uc003qdv.2_Missense_Mutation_p.E17K	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	70	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		AATACCTGCTCAGCTGCCTGC	0.433			NA											4	78					0	0	0.000248	0	0
GLCCI1	113263	broad.mit.edu	37	7	8126004	8126004	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:8126004G>A	uc003srk.2	+	8	2039	c.1480G>A	c.(1480-1482)GTT>ATT	p.V494I		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	494											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		AACTCTGACCGTTGAGCAGCT	0.552			NA											5	274					0	0	0.000602	0	0
ISPD	729920	broad.mit.edu	37	7	16348241	16348241	+	Silent	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:16348241A>G	uc010ktx.2	-	4	696	c.696T>C	c.(694-696)TAT>TAC	p.Y232Y	ISPD_uc010kty.2_Silent_p.Y182Y	NM_001101426	NP_001094896	A4D126	ISPD_HUMAN	notch1-induced protein isoform a	232					isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1						ATTCCAAGTCATAGTCACTAC	0.373			NA								Multiple Myeloma(15;0.18)			4	15					0	0	0.000248	0	0
SP4	6671	broad.mit.edu	37	7	21469643	21469643	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:21469643C>T	uc003sva.2	+	3	1041	c.860C>T	c.(859-861)GCT>GTT	p.A287V	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	287					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GGCCAGCCTGCTGCTACTGCT	0.517			NA											6	87					0	0	0.001984	0	0
URGCP	55665	broad.mit.edu	37	7	43917298	43917298	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:43917298C>A	uc003tiw.2	-	6	1821	c.1764G>T	c.(1762-1764)ACG>ACT	p.T588T	URGCP_uc003tiu.2_Silent_p.T545T|URGCP_uc003tiv.2_Silent_p.T513T|URGCP_uc003tix.2_Silent_p.T579T|URGCP_uc003tiy.2_Silent_p.T545T|URGCP_uc003tiz.2_Silent_p.T545T|URGCP_uc011kbj.1_Silent_p.T545T	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	588					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GGGTGAGAAGCGTCTCCGGAG	0.647			NA											12	67					0.00185496	0.00213601	0.001855	1	0
CALCR	799	broad.mit.edu	37	7	93055880	93055880	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:93055880G>A	uc003umv.1	-	15	1576	c.1315C>T	c.(1315-1317)CAA>TAA	p.Q439*	CALCR_uc011kia.1_Nonsense_Mutation_p.Q219*|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Nonsense_Mutation_p.Q405*|CALCR_uc003umw.2_Nonsense_Mutation_p.Q405*	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	421	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGGGCCCATTGGCGCTTCACG	0.532			NA											11	32					0	0	0.008291	0	0
RELN	5649	broad.mit.edu	37	7	103202036	103202036	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:103202036C>G	uc003vca.2	-	36	5632	c.5472G>C	c.(5470-5472)GAG>GAC	p.E1824D	RELN_uc010liz.2_Missense_Mutation_p.E1824D	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1824					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GATTCCCCCTCTCTGCACCAT	0.418	NSCLC(146;835 1944 15585 22231 52158)		NA											21	152					0	0	0.00632	0	0
HIPK2	28996	broad.mit.edu	37	7	139416071	139416071	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:139416071C>A	uc003vvf.3	-	2	937	c.763G>T	c.(763-765)GCC>TCC	p.A255S	HIPK2_uc003vvd.3_Missense_Mutation_p.A255S	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	255	Protein kinase.|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					TAGTCATCGGCACTCTCCGTG	0.517			NA											9	38					1.12685e-05	1.39936e-05	0.004482	1	0
LZTS1	11178	broad.mit.edu	37	8	20107693	20107693	+	Missense_Mutation	SNP	C	C	A	rs148039718	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:20107693C>A	uc003wzr.2	-	3	1442	c.1331G>T	c.(1330-1332)GGC>GTC	p.G444V	LZTS1_uc010ltg.1_Missense_Mutation_p.G444V	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	444					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		CAGCTCCAGGCCCTTGGTGCG	0.652			NA											21	112					4.59853e-10	6.56933e-10	0.005443	1	0
KCNB2	9312	broad.mit.edu	37	8	73848226	73848226	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:73848226C>A	uc003xzb.2	+	3	1224	c.636C>A	c.(634-636)CTC>CTA	p.L212L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	212	Helical; Name=Segment S1; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTTTGTCTCTCAATACGCTGC	0.473			NA											62	178					6.5469e-37	1.09115e-36	0.00361	1	0
PLEC	5339	broad.mit.edu	37	8	144993590	144993590	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:144993590C>A	uc003zaf.1	-	32	10980	c.10810G>T	c.(10810-10812)GCC>TCC	p.A3604S	PLEC_uc003zab.1_Missense_Mutation_p.A3467S|PLEC_uc003zac.1_Missense_Mutation_p.A3471S|PLEC_uc003zad.2_Missense_Mutation_p.A3467S|PLEC_uc003zae.1_Missense_Mutation_p.A3435S|PLEC_uc003zag.1_Missense_Mutation_p.A3445S|PLEC_uc003zah.2_Missense_Mutation_p.A3453S|PLEC_uc003zaj.2_Missense_Mutation_p.A3494S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3604	Globular 2.|Plectin 15.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGATCTGGGCCTCCAGCAGG	0.667			NA											9	60					3.09899e-07	4.11753e-07	0.004482	1	0
LRRC24	441381	broad.mit.edu	37	8	145749504	145749504	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:145749504C>T	uc003zdm.2	-	4	729	c.597G>A	c.(595-597)CTG>CTA	p.L199L	LRRC24_uc003zdn.2_Silent_p.L196L|LRRC14_uc003zdk.1_3'UTR|LRRC14_uc003zdl.1_3'UTR|LRRC14_uc003zdo.2_Intron	NM_001024678	NP_001019849	Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24 precursor	199						integral to membrane					0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGTGAGGCGCAGGACTTGCA	0.637			NA											65	190					0	0	0.00361	0	0
ZNF250	58500	broad.mit.edu	37	8	146112249	146112249	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:146112249G>C	uc003zeq.3	-	5	454	c.337C>G	c.(337-339)CAA>GAA	p.Q113E	COMMD5_uc010mgf.2_5'UTR|ZNF250_uc003zer.3_Missense_Mutation_p.Q108E|ZNF250_uc010mgg.2_Missense_Mutation_p.Q108E	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		AAACTGTCTTGTTGTGTACAG	0.373	NSCLC(16;520 556 24096 40084 43446)		NA											16	138					0	0	0.001523	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608545	84608545	+	Missense_Mutation	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:84608545T>C	uc004amn.2	+	4	3207	c.3160T>C	c.(3160-3162)TCA>CCA	p.S1054P		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1054						integral to membrane					0						CCTTGTCACTTCACCTGTCAA	0.448			NA											4	232					0	0	0.000602	0	0
CTSL1	1514	broad.mit.edu	37	9	90343602	90343602	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:90343602G>C	uc004aph.2	+	5	849	c.499G>C	c.(499-501)GTA>CTA	p.V167L	CTSL1_uc004api.2_Missense_Mutation_p.V167L|CTSL1_uc004apj.2_Missense_Mutation_p.V112L|CTSL1_uc010mqh.2_Intron|CTSL1_uc004apk.2_Missense_Mutation_p.V167L|CTSL1_uc004apl.2_Missense_Mutation_p.V167L	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	167					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GCAGAATCTGGTAGACTGCTC	0.493			NA											5	116					0	0	0.000602	0	0
ASTN2	23245	broad.mit.edu	37	9	119567928	119567928	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:119567928G>T	uc004bjs.1	-	13	2480	c.2379C>A	c.(2377-2379)GTC>GTA	p.V793V	ASTN2_uc004bjr.1_Silent_p.V789V|ASTN2_uc004bjt.1_Silent_p.V742V	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	793	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TCATCTGGAAGACTTGGCCTT	0.488			NA											20	114					3.73988e-18	5.92148e-18	0.00632	1	0
SETX	23064	broad.mit.edu	37	9	135210025	135210025	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:135210025T>A	uc004cbk.2	-	7	991	c.808A>T	c.(808-810)ATA>TTA	p.I270L		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	270					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GTGTGAAGTATCGATTGCATA	0.373			NA											11	68					0	0	0.001855	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999372	27999372	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:27999372G>C	uc004dbx.1	-	1	195	c.80C>G	c.(79-81)TCT>TGT	p.S27C		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	27										ovary(3)|skin(1)	4						TGCTACTCCAGACTGCTCCTC	0.567			NA											10	45					0	0	0.001368	0	0
FAM47A	158724	broad.mit.edu	37	X	34148985	34148985	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:34148985G>T	uc004ddg.2	-	1	1444	c.1411C>A	c.(1411-1413)CCC>ACC	p.P471T		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	471										ovary(4)|central_nervous_system(1)	5						TGAGTCTCGGGAGGCTGCAGG	0.602			NA											11	68					2.27111e-07	3.06036e-07	0.001368	1	0
FAM47B	170062	broad.mit.edu	37	X	34961812	34961812	+	Silent	SNP	C	C	G	rs142684131		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:34961812C>G	uc004ddi.1	+	1	882	c.864C>G	c.(862-864)CCC>CCG	p.P288P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	288	Pro-rich.									ovary(3)|breast(1)	4						CGGAGCCTCCCGAGACTCGCG	0.627			NA											10	71					0	0	0.000978	0	0
RGN	9104	broad.mit.edu	37	X	46951083	46951083	+	Missense_Mutation	SNP	G	G	A	rs147490967	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:46951083G>A	uc004dgz.1	+	6	1538	c.569G>A	c.(568-570)CGC>CAC	p.R190H	RGN_uc004dha.1_Missense_Mutation_p.R190H|RGN_uc010nho.1_Missense_Mutation_p.R137H|RGN_uc010nhp.1_Missense_Mutation_p.R118H	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	190					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						ATAGCCAACCGCAGAAGTGTT	0.428			NA											11	64					0	0	0.004007	0	0
GPKOW	27238	broad.mit.edu	37	X	48978831	48978831	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:48978831C>A	uc004dmr.2	-	3	380	c.373G>T	c.(373-375)GAC>TAC	p.D125Y		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	125						nucleus	nucleic acid binding			ovary(2)	2						AGCGTGGGGTCGACACCCGCA	0.567			NA											5	31					3.59834e-05	4.35467e-05	0.001168	1	0
RPL36A	6173	broad.mit.edu	37	X	100646034	100646034	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:100646034G>A	uc004ehk.2	+	1	87	c.3G>A	c.(1-3)ATG>ATA	p.M1I	BTK_uc010nno.2_5'Flank|RPL36A_uc004ehj.1_Missense_Mutation_p.M1I	NM_021029	NP_066357	P83881	RL36A_HUMAN	ribosomal protein L36a	1					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						ACGCAAGCATGGTAGGACTTG	0.582			NA									OREG0019892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	112					0	0	0.001368	0	0
KIAA1210	57481	broad.mit.edu	37	X	118238956	118238956	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:118238956T>G	uc004era.3	-	7	1067	c.1067A>C	c.(1066-1068)CAG>CCG	p.Q356P		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	356										ovary(4)|skin(1)	5						TATACTCACCTGAGTCGCTGT	0.428			NA											29	184					0	0	0.00623	0	0
AFF2	2334	broad.mit.edu	37	X	148037640	148037640	+	Missense_Mutation	SNP	C	C	A	rs140525796	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:148037640C>A	uc004fcp.2	+	11	2544	c.2065C>A	c.(2065-2067)CCT>ACT	p.P689T	AFF2_uc004fcq.2_Missense_Mutation_p.P679T|AFF2_uc004fcr.2_Missense_Mutation_p.P650T|AFF2_uc011mxb.1_Missense_Mutation_p.P654T|AFF2_uc004fcs.2_Missense_Mutation_p.P656T|AFF2_uc011mxc.1_Missense_Mutation_p.P330T	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	689					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTAACATCCCTTTGGCTCC	0.488			NA											15	100					8.60227e-14	1.28695e-13	0.004007	1	0
SLC6A8	6535	broad.mit.edu	37	X	152960251	152960251	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:152960251G>T	uc004fib.3	+	12	1952	c.1674G>T	c.(1672-1674)GAG>GAT	p.E558D	SLC6A8_uc004fic.3_Missense_Mutation_p.E548D|SLC6A8_uc011myx.1_Missense_Mutation_p.E443D|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	558	Extracellular (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GGTGGGGTGAGGCCATGGGCT	0.617			NA											11	62					1.61879e-10	2.33008e-10	0.001368	1	0
SSR4	6748	broad.mit.edu	37	X	153062934	153062934	+	Missense_Mutation	SNP	G	G	T	rs149873632		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:153062934G>T	uc004fiw.2	+	3	257	c.208G>T	c.(208-210)GTC>TTC	p.V70F	IDH3G_uc004fip.2_5'Flank|IDH3G_uc004fiq.2_5'Flank|IDH3G_uc010num.2_5'Flank|IDH3G_uc004fir.2_5'Flank|IDH3G_uc004fit.1_5'Flank|IDH3G_uc004fis.2_5'Flank|SSR4_uc004fiv.2_Missense_Mutation_p.V81F	NM_006280	NP_006271	P51571	SSRD_HUMAN	signal sequence receptor, delta precursor	70	Lumenal (Potential).				intracellular protein transport	integral to membrane|Sec61 translocon complex	calcium ion binding|protein binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTATGCTGACGTCGGTGGAAA	0.617			NA											12	96					2.5808e-16	4.01927e-16	0.006122	1	0
SLAMF6	114836	broad.mit.edu	37	1	160458940	160458940	+	Frame_Shift_Del	DEL	C	C	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:160458940delC	uc001fwe.1	-	6	877	c.817delG	c.(817-819)GAGfs	p.E273fs	SLAMF6_uc001fwd.1_Frame_Shift_Del_p.E272fs|SLAMF6_uc010pjh.1_Frame_Shift_Del_p.E223fs|SLAMF6_uc010pji.1_Frame_Shift_Del_p.E162fs|SLAMF6_uc010pjj.1_3'UTR	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	273	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			GAAACATACTCTAGGTTCCTT	0.473			NA											19	167	---	---	---	---	NA	NA	NA	NA	NA
DHX32	55760	broad.mit.edu	37	10	127548457	127548461	+	Frame_Shift_Del	DEL	ATGAA	ATGAA	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	ATGAA	ATGAA	-	-	ATGAA	ATGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:127548457_127548461delATGAA	uc001ljf.1	-	3	1051_1055	c.560_564delTTCAT	c.(559-564)ATTCATfs	p.I187fs	DHX32_uc001ljg.1_Frame_Shift_Del_p.I187fs|DHX32_uc009yam.1_Frame_Shift_Del_p.I23fs	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	187_188	DEAH box.|Helicase ATP-binding.					mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGCTTCTTTCATGAATATCATCTAA	0.366			NA											9	65	---	---	---	---	NA	NA	NA	NA	NA
HSF4	3299	broad.mit.edu	37	16	67201666	67201666	+	Frame_Shift_Del	DEL	G	G	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:67201666delG	uc002erl.1	+	11	1863	c.898delG	c.(898-900)GGGfs	p.G300fs	HSF4_uc002erm.1_Intron|HSF4_uc002ern.1_Intron|HSF4_uc010cec.1_Intron|NOL3_uc010vjc.1_5'Flank	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	300	Interactions with DUSP26, MAPK1 and MAPK2.				response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGCCAGTCCAGGGGGGGATGG	0.647			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MSL1	339287	broad.mit.edu	37	17	38290535	38290535	+	Frame_Shift_Del	DEL	T	T	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:38290535delT	uc002hub.2	+	9	1174	c.1155delT	c.(1153-1155)AATfs	p.N385fs	MSL1_uc002hua.3_Frame_Shift_Del_p.N323fs|MSL1_uc002hud.2_Frame_Shift_Del_p.N125fs	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	586					histone H4-K16 acetylation	MSL complex					0						TTGCCAGGAATTTTGAGCTAC	0.463			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
PRR12	57479	broad.mit.edu	37	19	50098807	50098808	+	Frame_Shift_Ins	INS	-	-	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:50098807_50098808insC	uc002poo.3	+	4	1215_1216	c.1215_1216insC	c.(1213-1218)AGGCCCfs	p.R405fs		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment_146							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GTGCCACCAGGCCCCCCCCACC	0.688			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
RICTOR	253260	broad.mit.edu	37	5	38942422	38942423	+	Frame_Shift_Ins	INS	-	-	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:38942422_38942423insT	uc003jlp.2	-	38	5134_5135	c.5110_5111insA	c.(5110-5112)ACAfs	p.T1704fs	RICTOR_uc003jlo.2_Frame_Shift_Ins_p.T1728fs|RICTOR_uc010ivf.2_Frame_Shift_Ins_p.T1381fs	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1704					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTCAGCAGATGTATCAACTATA	0.347			NA											14	209	---	---	---	---	NA	NA	NA	NA	NA
C6	729	broad.mit.edu	37	5	41201800	41201801	+	Frame_Shift_Ins	INS	-	-	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:41201800_41201801insA	uc003jmk.2	-	3	369_370	c.159_160insT	c.(157-162)GATAAGfs	p.D53fs	C6_uc003jml.1_Frame_Shift_Ins_p.D53fs	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	53_54	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGGTAGTACTTATCTACTACTA	0.391			NA											41	94	---	---	---	---	NA	NA	NA	NA	NA
MTAP	4507	broad.mit.edu	37	9	21816764	21816765	+	Frame_Shift_Ins	INS	-	-	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:21816764_21816765insT	uc003zph.2	+	3	285_286	c.172_173insT	c.(172-174)CTTfs	p.L58fs	MTAP_uc003zpi.1_Frame_Shift_Ins_p.L58fs|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Frame_Shift_Ins_p.L75fs|MTAP_uc011lnl.1_5'Flank	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	58					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TTGCGTCCTCCTTGCAAGGTAT	0.322			NA											57	218	---	---	---	---	NA	NA	NA	NA	NA
