Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GNB1	2782	broad.mit.edu	37	1	1721961	1721961	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:1721961G>C	uc001aif.2	-	9	904	c.572C>G	c.(571-573)TCT>TGT	p.S191C	GNB1_uc009vky.2_Missense_Mutation_p.S91C	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	191	WD 4.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		AGGAGCAAGAGAAAGGCTCAT	0.577			NA											6	53					0	0	0.001984	0	0
IL22RA1	58985	broad.mit.edu	37	1	24449853	24449853	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:24449853G>T	uc001biq.1	-	6	770	c.731C>A	c.(730-732)GCA>GAA	p.A244E	IL22RA1_uc010oeg.1_Missense_Mutation_p.A176E|IL22RA1_uc009vrb.1_Missense_Mutation_p.A108E|IL22RA1_uc010oeh.1_Missense_Mutation_p.A244E	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	244	Helical; (Potential).					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCAGAGTACTGCGACGAGGAA	0.612			NA											22	18					1.10923e-09	1.18062e-09	0.00278	1	0
SLFNL1	200172	broad.mit.edu	37	1	41483474	41483474	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41483474C>T	uc001cgm.1	-	3	1010	c.790G>A	c.(790-792)GAC>AAC	p.D264N	SLFNL1_uc009vwf.1_Missense_Mutation_p.D264N|SLFNL1_uc001cgn.1_Missense_Mutation_p.D205N|SLFNL1_uc009vwg.1_Missense_Mutation_p.D264N	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	264	ATP (Potential).						ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				AGGCCGCTGTCCTCTACTCCC	0.662			NA											14	57					0	0	0.003163	0	0
SLFNL1	200172	broad.mit.edu	37	1	41483477	41483477	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41483477C>A	uc001cgm.1	-	3	1007	c.787G>T	c.(787-789)GAG>TAG	p.E263*	SLFNL1_uc009vwf.1_Nonsense_Mutation_p.E263*|SLFNL1_uc001cgn.1_Nonsense_Mutation_p.E204*|SLFNL1_uc009vwg.1_Nonsense_Mutation_p.E263*	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	263	ATP (Potential).						ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCGCTGTCCTCTACTCCCACG	0.672			NA											14	58					2.32078e-09	2.45797e-09	0.003163	1	0
SLFNL1	200172	broad.mit.edu	37	1	41486212	41486212	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41486212C>G	uc001cgm.1	-	2	341	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	SLFNL1_uc009vwf.1_Missense_Mutation_p.E41Q|SLFNL1_uc001cgn.1_Missense_Mutation_p.E41Q|SLFNL1_uc009vwg.1_Missense_Mutation_p.E41Q	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	41							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GGAGCCTCCTCGAGGTCAGAG	0.632			NA											14	104					0	0	0.003163	0	0
SLFNL1	200172	broad.mit.edu	37	1	41486281	41486281	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41486281C>T	uc001cgm.1	-	2	272	c.52G>A	c.(52-54)GAG>AAG	p.E18K	SLFNL1_uc009vwf.1_Missense_Mutation_p.E18K|SLFNL1_uc001cgn.1_Missense_Mutation_p.E18K|SLFNL1_uc009vwg.1_Missense_Mutation_p.E18K	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	18							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCCCAGGACTCCATGAAGGGC	0.607			NA											10	82					0	0	0.003163	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448792	89448792	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:89448792C>T	uc009wcx.2	-	3	1434	c.718G>A	c.(718-720)GAT>AAT	p.D240N	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.D240N	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	240							nucleotide binding|RNA binding				0						TAAGTATAATCTCGTGGTGGT	0.428			NA											32	33					0	0	0.003755	0	0
PLEKHO1	51177	broad.mit.edu	37	1	150131230	150131230	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:150131230G>C	uc001ett.2	+	6	1020	c.742G>C	c.(742-744)GAC>CAC	p.D248H	PLEKHO1_uc001etr.2_Missense_Mutation_p.D76H|PLEKHO1_uc001ets.2_Missense_Mutation_p.D65H|PLEKHO1_uc001etu.2_Missense_Mutation_p.D76H	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	248	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAAAAAACAGACAAAGGGGC	0.647			NA											27	25					0	0	0.009535	0	0
FLG	2312	broad.mit.edu	37	1	152282561	152282561	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:152282561C>G	uc001ezu.1	-	3	4837	c.4801G>C	c.(4801-4803)GAG>CAG	p.E1601Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1601	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTGTCCCTCACTGTCCCTG	0.592			NA							Ichthyosis				50	182					0	0	0.01441	0	0
ASH1L	55870	broad.mit.edu	37	1	155385641	155385641	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:155385641A>C	uc009wqq.2	-	6	6382	c.5902T>G	c.(5902-5904)TTG>GTG	p.L1968V	ASH1L_uc001fkt.2_Missense_Mutation_p.L1968V	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1968					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACAGGCTGCAAGGTACTTTCA	0.438			NA											15	73					0	0	0.004007	0	0
RXFP4	339403	broad.mit.edu	37	1	155912577	155912577	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:155912577C>T	uc010pgs.1	+	1	1098	c.1077C>T	c.(1075-1077)AGC>AGT	p.S359S		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	359	Cytoplasmic (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCCGGGAGAGCCGCCCTTCTA	0.632			NA											3	56					0	0	0.000602	0	0
INTS7	25896	broad.mit.edu	37	1	212118198	212118198	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:212118198G>C	uc001hiw.1	-	19	2634	c.2529C>G	c.(2527-2529)CTC>CTG	p.L843L	INTS7_uc009xdb.1_Silent_p.L823L|INTS7_uc001hix.1_Silent_p.L719L|INTS7_uc001hiy.1_Silent_p.L829L|INTS7_uc010pta.1_Silent_p.L794L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	843					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTTTGCGGAAGAGTCCTGGTT	0.478			NA											4	96					0	0	0.000602	0	0
ANKRD26	22852	broad.mit.edu	37	10	27328913	27328913	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:27328913G>A	uc001ith.2	-	21	2525	c.2353C>T	c.(2353-2355)CGA>TGA	p.R785*	ANKRD26_uc001itg.2_Nonsense_Mutation_p.R472*|ANKRD26_uc009xku.1_Nonsense_Mutation_p.R786*	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	785	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CACAGTTCTCGTTCCCATTCA	0.299			NA											7	98					0	0	0.004482	0	0
MASTL	84930	broad.mit.edu	37	10	27448608	27448608	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:27448608G>A	uc001itm.2	+	3	1024	c.385G>A	c.(385-387)GAT>AAT	p.D129N	MASTL_uc001itl.2_Missense_Mutation_p.D129N|MASTL_uc009xkw.1_Missense_Mutation_p.D129N|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	129	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TGGTTATTTTGATGAAGAGAT	0.338			NA											25	74					0	0	0.003954	0	0
PARD3	56288	broad.mit.edu	37	10	34663884	34663884	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:34663884G>A	uc010qej.1	-	11	1586	c.1586C>T	c.(1585-1587)TCG>TTG	p.S529L	PARD3_uc010qek.1_Missense_Mutation_p.S529L|PARD3_uc010qel.1_Missense_Mutation_p.S529L|PARD3_uc010qem.1_Missense_Mutation_p.S529L|PARD3_uc010qen.1_Missense_Mutation_p.S529L|PARD3_uc010qeo.1_Missense_Mutation_p.S529L|PARD3_uc010qep.1_Missense_Mutation_p.S485L|PARD3_uc010qeq.1_Missense_Mutation_p.S485L|PARD3_uc001ixo.1_Missense_Mutation_p.S259L|PARD3_uc001ixp.1_Missense_Mutation_p.S394L|PARD3_uc001ixq.1_Missense_Mutation_p.S529L|PARD3_uc001ixr.1_Missense_Mutation_p.S529L|PARD3_uc001ixt.1_Missense_Mutation_p.S350L|PARD3_uc001ixu.1_Missense_Mutation_p.S485L|PARD3_uc001ixs.1_Missense_Mutation_p.S182L	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	529	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TCTCAACAGCGAAACAACTTC	0.428			NA											39	73					0	0	0.007835	0	0
FZD8	8325	broad.mit.edu	37	10	35928705	35928705	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:35928705G>A	uc001iyz.1	-	1	1658	c.1653C>T	c.(1651-1653)CTC>CTT	p.L551L		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	551	Helical; Name=6; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						GCTCGTAGAAGAGGCAGGCGA	0.697			NA											5	30					0	0	0.001168	0	0
HERC4	26091	broad.mit.edu	37	10	69832647	69832647	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:69832647C>G	uc001jng.3	-	3	530	c.219G>C	c.(217-219)AAG>AAC	p.K73N	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.K73N|HERC4_uc009xpr.2_Missense_Mutation_p.K73N|HERC4_uc001jni.3_5'UTR|HERC4_uc001jnj.2_Missense_Mutation_p.K73N|HERC4_uc001jnk.2_Missense_Mutation_p.K73N	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	73	RCC1 2.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						TACCTGGTTTCTTTCTGGATT	0.303			NA											4	81					0	0	0.000602	0	0
HK1	3098	broad.mit.edu	37	10	71158502	71158502	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:71158502G>C	uc001jpl.3	+	17	2628	c.2527G>C	c.(2527-2529)GAT>CAT	p.D843H	HK1_uc001jpg.3_Missense_Mutation_p.D831H|HK1_uc001jph.3_Missense_Mutation_p.D847H|HK1_uc001jpi.3_Missense_Mutation_p.D847H|HK1_uc001jpj.3_Missense_Mutation_p.D878H|HK1_uc001jpk.3_Missense_Mutation_p.D842H	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	843	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						TGCGGTTGTGGATAAGATCCG	0.582			NA											6	89					0	0	0.004482	0	0
HK1	3098	broad.mit.edu	37	10	71158543	71158543	+	Silent	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:71158543G>T	uc001jpl.3	+	17	2669	c.2568G>T	c.(2566-2568)GTG>GTT	p.V856V	HK1_uc001jpg.3_Silent_p.V844V|HK1_uc001jph.3_Silent_p.V860V|HK1_uc001jpi.3_Silent_p.V860V|HK1_uc001jpj.3_Silent_p.V891V|HK1_uc001jpk.3_Silent_p.V855V	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	856	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GTCTGAATGTGACTGTGGGAG	0.607			NA											7	85					0.00307968	0.00313806	0.00308	1	0
HIF1AN	55662	broad.mit.edu	37	10	102304755	102304755	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:102304755C>G	uc001krj.3	+	4	700	c.625C>G	c.(625-627)CAG>GAG	p.Q209E		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	209	JmjC.|Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CTTTTTTGCTCAGATAAAAGG	0.448			NA											15	64					0	0	0.006122	0	0
TAF5	6877	broad.mit.edu	37	10	105145201	105145201	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:105145201C>G	uc001kwv.2	+	8	1806	c.1783C>G	c.(1783-1785)CCA>GCA	p.P595A	TAF5_uc010qqq.1_Intron	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	595	WD 3.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACAATTTTCTCCATATGGATA	0.413			NA											10	39					0	0	0.010729	0	0
C10orf81	79949	broad.mit.edu	37	10	115536935	115536935	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:115536935G>C	uc001lat.1	+	11	1646	c.1084G>C	c.(1084-1086)GAT>CAT	p.D362H	C10orf81_uc001lar.1_Intron|C10orf81_uc009xyc.1_Missense_Mutation_p.D280H|C10orf81_uc001las.1_Missense_Mutation_p.D280H|C10orf81_uc001lau.1_Missense_Mutation_p.D196H	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	376										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TTGCCACGGAGATCATCTTCT	0.547			NA											5	29					0	0	0.000602	0	0
EBF3	253738	broad.mit.edu	37	10	131676071	131676071	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:131676071C>A	uc001lki.1	-	7	656	c.597G>T	c.(595-597)TTG>TTT	p.L199F		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	199	Interaction with DNA (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CTGCATTCTTCAAACAGTTCT	0.358			NA											15	34					3.99206e-14	4.29146e-14	0.007413	1	0
DPYSL4	10570	broad.mit.edu	37	10	134017270	134017270	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:134017270C>T	uc009ybb.2	+	13	1620	c.1466C>T	c.(1465-1467)GCG>GTG	p.A489V		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	489					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CGGCAGCTGGCGGAGATCCAC	0.716			NA											21	29					0	0	0.004656	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950336	2950336	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:2950336C>T	uc001lxa.1	-	1	315	c.259G>A	c.(259-261)GAG>AAG	p.E87K		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	87	PH.				apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCAGCTCTCGCCCGCGCAG	0.657			NA											11	29					0	0	0.013537	0	0
OR51L1	119682	broad.mit.edu	37	11	5020308	5020308	+	Silent	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:5020308C>G	uc010qyu.1	+	1	96	c.96C>G	c.(94-96)CTC>CTG	p.L32L		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCCATCCTCTTCTGTCTTG	0.423			NA											9	184					0	0	0.013537	0	0
FOLH1	2346	broad.mit.edu	37	11	49168488	49168488	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:49168488G>C	uc001ngy.2	-	19	2334	c.2073C>G	c.(2071-2073)ATC>ATG	p.I691M	FOLH1_uc001ngx.2_Missense_Mutation_p.S91C|FOLH1_uc001ngz.2_Missense_Mutation_p.I660M|FOLH1_uc009yly.2_Missense_Mutation_p.I676M|FOLH1_uc009ylz.2_Missense_Mutation_p.I645M|FOLH1_uc009yma.2_Missense_Mutation_p.I383M	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	691	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TTGGAGCATAGATGACATGCC	0.423			NA											23	85					0	0	0.011902	0	0
OR4C15	81309	broad.mit.edu	37	11	55321913	55321913	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:55321913C>T	uc010rig.1	+	1	131	c.131C>T	c.(130-132)CCT>CTT	p.P44L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TACATGATCCCTGTTGGAGCT	0.378			NA								HNSCC(20;0.049)			4	137					0	0	0.000602	0	0
OR8H3	390152	broad.mit.edu	37	11	55890191	55890191	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:55890191C>G	uc001nii.1	+	1	343	c.343C>G	c.(343-345)CTC>GTC	p.L115V		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					ATGTTATCTTCTCTCCTCAAT	0.473			NA											48	230					0	0	0.01441	0	0
OR9G4	283189	broad.mit.edu	37	11	56510847	56510847	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:56510847A>G	uc010rjo.1	-	1	441	c.441T>C	c.(439-441)TAT>TAC	p.Y147Y		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGGTACCTGAATAAAGCAATG	0.488			NA											7	158					0	0	0.00308	0	0
C11orf84	144097	broad.mit.edu	37	11	63585793	63585793	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:63585793C>G	uc001nxt.2	+	3	799	c.563C>G	c.(562-564)CCT>CGT	p.P188R		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	188	Pro-rich.										0						CCATCCCTCCCTAAAAGGAGC	0.632			NA											4	87					0	0	0.001168	0	0
PYGM	5837	broad.mit.edu	37	11	64521147	64521147	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:64521147G>A	uc001oax.3	-	11	2064	c.1247C>T	c.(1246-1248)GCG>GTG	p.A416V	PYGM_uc001oay.3_Missense_Mutation_p.A328V	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	416					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GAATGCGGCCGCCACCCGCTG	0.692			NA											7	20					0	0	0.006214	0	0
CAPN1	823	broad.mit.edu	37	11	64974124	64974124	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:64974124C>T	uc009yqd.1	+	13	1655	c.1544C>T	c.(1543-1545)TCA>TTA	p.S515L	CAPN1_uc001odf.1_Missense_Mutation_p.S515L|CAPN1_uc001odg.1_Missense_Mutation_p.S515L|CAPN1_uc010roa.1_Missense_Mutation_p.S256L	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	515	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CGCTTCTTCTCAGAGAAGAGT	0.647			NA											8	48					0	0	0.008291	0	0
CCDC87	55231	broad.mit.edu	37	11	66360198	66360198	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:66360198C>T	uc001oiq.3	-	1	357	c.289G>A	c.(289-291)GAG>AAG	p.E97K	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	97										ovary(1)|skin(1)	2						GCGGGCGGCTCCCGCCAGCTG	0.632			NA									OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	0.001855	0	0
LRP5	4041	broad.mit.edu	37	11	68181430	68181430	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:68181430G>A	uc001ont.2	+	12	2852	c.2777G>A	c.(2776-2778)TGC>TAC	p.C926Y	LRP5_uc009ysg.2_Missense_Mutation_p.C336Y	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	926	EGF-like 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GGCCACCGCTGCGGCTGCGCC	0.647			NA											9	36					0	0	0.004482	0	0
C2CD3	26005	broad.mit.edu	37	11	73803494	73803494	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:73803494C>T	uc001ouu.2	-	19	3711	c.3484G>A	c.(3484-3486)GAG>AAG	p.E1162K		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1162						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TTCCTGTTCTCAATCCTGGGG	0.358			NA											34	101					0	0	0.009718	0	0
INTS4	92105	broad.mit.edu	37	11	77618802	77618802	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:77618802G>C	uc001oys.2	-	16	2005	c.1977C>G	c.(1975-1977)TTC>TTG	p.F659L	C11orf67_uc001oyp.2_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	659					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AGGTGGCAGAGAAATCAGCTA	0.408			NA											4	125					0	0	0.000602	0	0
ALG8	79053	broad.mit.edu	37	11	77823813	77823813	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:77823813G>A	uc001oza.1	-	8	846	c.781C>T	c.(781-783)CAG>TAG	p.Q261*	ALG8_uc001oyz.1_Nonsense_Mutation_p.Q261*|ALG8_uc009yux.1_Nonsense_Mutation_p.Q159*	NM_024079	NP_076984	Q9BVK2	ALG8_HUMAN	dolichyl pyrophosphate Glc1Man9GlcNAc2	261					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|pancreas(1)	3	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			TGAGGCAGCTGATTCTGTTGA	0.393			NA											5	31					0	0	0.001984	0	0
CASP1	834	broad.mit.edu	37	11	104897032	104897032	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:104897032C>T	uc010rve.1	-	9	1185	c.1168G>A	c.(1168-1170)GAA>AAA	p.E390K	CASP1_uc001pig.2_Missense_Mutation_p.E297K|CASP1_uc001pik.2_Missense_Mutation_p.E353K|CASP1_uc010rvf.1_Missense_Mutation_p.E297K|CASP1_uc010rvg.1_Missense_Mutation_p.E369K|CASP1_uc010rvh.1_Missense_Mutation_p.E249K|CASP1_uc010rvi.1_Missense_Mutation_p.E74K|CASP1_uc001pim.3_Missense_Mutation_p.E390K|CASP1_uc009yxi.2_Missense_Mutation_p.E369K|CASP1_uc010rvj.1_Missense_Mutation_p.E390K	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	390					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	GTCACTCTTTCAGTGGTGGGC	0.423	NSCLC(41;1246 1743 4934)		NA											12	75					0	0	0.00245	0	0
ROBO3	64221	broad.mit.edu	37	11	124744063	124744063	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:124744063C>T	uc001qbc.2	+	12	2074	c.1882C>T	c.(1882-1884)CTG>TTG	p.L628L	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	628	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTACCTGTTTCTGGTTCGAGC	0.602			NA											5	150					0	0	0.000602	0	0
APLP2	334	broad.mit.edu	37	11	129999975	129999975	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:129999975G>C	uc010sby.1	+	11	1655	c.1498G>C	c.(1498-1500)GAG>CAG	p.E500Q	APLP2_uc001qfp.2_Missense_Mutation_p.E500Q|APLP2_uc001qfq.2_Missense_Mutation_p.E444Q|APLP2_uc010sbz.1_Missense_Mutation_p.E288Q|APLP2_uc001qfr.2_Missense_Mutation_p.E266Q|APLP2_uc001qfs.2_Missense_Mutation_p.E271Q|APLP2_uc001qfv.2_Missense_Mutation_p.E391Q	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	500	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGTCCGTGCTGAGAACAAAGA	0.468			NA											21	138					0	0	0.00278	0	0
H3F3C	440093	broad.mit.edu	37	12	31944812	31944812	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:31944812C>T	uc001rkr.2	-	1	364	c.289G>A	c.(289-291)GAA>AAA	p.E97K		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	97					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGGTACGCTTCGCTAGCCTCC	0.572			NA								HNSCC(67;0.2)			8	100					0	0	0.006214	0	0
DNAJC14	85406	broad.mit.edu	37	12	56188646	56188646	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:56188646C>T	uc001shu.1	-	11	2427	c.2371G>A	c.(2371-2373)GAA>AAA	p.E791K	SARNP_uc009zoa.2_RNA|SARNP_uc001shs.3_RNA|SARNP_uc001sht.2_Missense_Mutation_p.E108K|SARNP_uc001shv.3_Missense_Mutation_p.E108K	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	Error:Variant_position_missing_in_Q6Y2X3_after_alignment					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TTGAATCGTTCAGCCCTCTTC	0.418			NA											7	18					0	0	0.008291	0	0
DGKA	1606	broad.mit.edu	37	12	56346586	56346586	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:56346586C>A	uc001sij.2	+	21	2076	c.1812C>A	c.(1810-1812)AGC>AGA	p.S604R	DGKA_uc009zod.1_Missense_Mutation_p.S523R|DGKA_uc001sik.2_Missense_Mutation_p.S604R|DGKA_uc001sil.2_Missense_Mutation_p.S604R|DGKA_uc001sim.2_Missense_Mutation_p.S604R|DGKA_uc001sin.2_Missense_Mutation_p.S604R|DGKA_uc009zof.2_Missense_Mutation_p.S250R|DGKA_uc001sio.2_Missense_Mutation_p.S346R	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	604					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	ACATCCCTAGCATGCATGGTG	0.552			NA											100	83					4.85316e-53	5.2966e-53	0.01441	1	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716			NA											5	10					0	0	0.001984	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72017964	72017964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:72017964G>A	uc001swo.2	-	23	4785	c.4426C>T	c.(4426-4428)CAG>TAG	p.Q1476*		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1476					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TCTAAAAGCTGAAAGGACAAA	0.408			NA											13	161					0	0	0.00245	0	0
PIWIL1	9271	broad.mit.edu	37	12	130827556	130827556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:130827556C>T	uc001uik.2	+	3	190	c.100C>T	c.(100-102)CAG>TAG	p.Q34*	PIWIL1_uc001uij.1_Nonsense_Mutation_p.Q34*	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	34					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TGGTTATATTCAGCCTAGGCC	0.478			NA											17	42					0	0	0.012319	0	0
KBTBD6	89890	broad.mit.edu	37	13	41704658	41704658	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr13:41704658C>G	uc001uxu.1	-	1	2279	c.1990G>C	c.(1990-1992)GAT>CAT	p.D664H	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.D598H|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	664	Kelch 6.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AAATCATCATCAGAAAGAGAA	0.418			NA											14	22					0	0	0.00499	0	0
RNASE1	6035	broad.mit.edu	37	14	21269841	21269841	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:21269841C>T	uc001vyf.2	-	2	563	c.387G>A	c.(385-387)CCG>CCA	p.P129P	RNASE1_uc001vyg.2_Silent_p.P129P|RNASE1_uc001vyh.2_Silent_p.P129P|RNASE1_uc001vyi.2_Silent_p.P129P	NM_198232	NP_937875	P07998	RNAS1_HUMAN	pancreatic ribonuclease precursor	129						extracellular region	nucleic acid binding|pancreatic ribonuclease activity|protein binding				0	all_cancers(95;0.00671)	all_lung(585;0.235)	Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)		GTCTCTCCTTCGGGCTGGTCC	0.562			NA											29	63					0	0	0.012213	0	0
FAM179B	23116	broad.mit.edu	37	14	45431675	45431675	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:45431675C>T	uc001wvv.2	+	1	260	c.51C>T	c.(49-51)CTC>CTT	p.L17L	FAM179B_uc001wvw.2_Silent_p.L17L|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Silent_p.L17L|FAM179B_uc001wvu.2_Silent_p.L17L	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	17							binding			skin(2)|upper_aerodigestive_tract(1)	3						TTCCAGTCCTCTCTACCTATC	0.582			NA											7	17					0	0	0.001984	0	0
ADCK1	57143	broad.mit.edu	37	14	78399726	78399726	+	Missense_Mutation	SNP	C	C	G	rs141850399		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:78399726C>G	uc001xui.2	+	11	1663	c.1564C>G	c.(1564-1566)CCA>GCA	p.P522A	ADCK1_uc001xuj.2_Missense_Mutation_p.P454A|ADCK1_uc001xul.2_Missense_Mutation_p.P229A	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	529						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GTTCCCTGCTCCACTCTGAGT	0.557			NA											4	120					0	0	0.001168	0	0
TCL1A	8115	broad.mit.edu	37	14	96178093	96178093	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:96178093C>T	uc001yfc.3	-	3	474	c.344G>A	c.(343-345)TGA>TAA	p.*115*	TCL1A_uc001yfb.3_Silent_p.*115*	NM_001098725	NP_001092195	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	115					multicellular organismal development	endoplasmic reticulum|microsome				lung(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CACCATACATCAGTCATCTGG	0.557	Ovarian(96;1068 2019 35393 39316)		NA	T	TRA@	T-CLL								9	13					0	0	0.006214	0	0
TMEM87A	25963	broad.mit.edu	37	15	42510006	42510006	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:42510006C>T	uc010udd.1	-	19	1780	c.1621G>A	c.(1621-1623)GAT>AAT	p.D541N		NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	541						integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		CCAACCTCATCTGAATCCAGA	0.343			NA											36	54					0	0	0.011902	0	0
UBR1	197131	broad.mit.edu	37	15	43328728	43328728	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:43328728G>A	uc001zqq.2	-	18	2152	c.2086C>T	c.(2086-2088)CAG>TAG	p.Q696*	UBR1_uc010udk.1_Nonsense_Mutation_p.Q696*	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	696					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ATAGGTACCTGAAGCATGATG	0.269			NA											36	74					0	0	0.007835	0	0
GNB5	10681	broad.mit.edu	37	15	52433340	52433340	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:52433340C>T	uc002abt.1	-	7	689	c.624G>A	c.(622-624)ATG>ATA	p.M208I	GNB5_uc002abr.1_Missense_Mutation_p.M166I|GNB5_uc002abs.1_Intron	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	208	WD 3.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		TATTTACCTGCATGTCAGAGT	0.507			NA											15	64					0	0	0.00278	0	0
CSNK1G1	53944	broad.mit.edu	37	15	64506298	64506298	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:64506298G>A	uc002anf.2	-	6	950	c.470C>T	c.(469-471)TCA>TTA	p.S157L	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.S157L|CSNK1G1_uc002anh.1_Missense_Mutation_p.S157L|CSNK1G1_uc002anj.2_Missense_Mutation_p.S139L	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	157	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						GAGGTTCTTTGAGTGCACGTA	0.373			NA											31	118					0	0	0.007835	0	0
LMAN1L	79748	broad.mit.edu	37	15	75115958	75115958	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:75115958G>A	uc002ayt.1	+	12	1260	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	LMAN1L_uc010bke.1_Missense_Mutation_p.E408K|CPLX3_uc002ayu.1_5'Flank	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	420	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						TGTGGGCATTGAGCATCATTT	0.597			NA											17	62					0	0	0.007413	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562495	75562495	+	Silent	SNP	G	G	T	rs138154232	by1000genomes	TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:75562495G>T	uc002azs.1	+	18	2078	c.2001G>T	c.(1999-2001)CCG>CCT	p.P667P	uc002azu.1_5'Flank|uc010ulz.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	679										ovary(1)	1						ACAACCCCCCGGTACAGCAGA	0.602			NA											5	71					5.9392e-07	6.22892e-07	0.001168	1	0
IREB2	3658	broad.mit.edu	37	15	78777160	78777160	+	Missense_Mutation	SNP	C	C	T	rs149176868		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:78777160C>T	uc002bdr.2	+	12	1633	c.1471C>T	c.(1471-1473)CAT>TAT	p.H491Y	IREB2_uc010unb.1_Missense_Mutation_p.H241Y	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	491							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TGTCTCCATTCATTATGAAGG	0.353	NSCLC(200;764 2208 35157 49871 50830)		NA											4	63					0	0	0.009096	0	0
FSD2	123722	broad.mit.edu	37	15	83455853	83455853	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:83455853C>T	uc002bjd.2	-	2	457	c.290G>A	c.(289-291)AGA>AAA	p.R97K	FSD2_uc010uol.1_Missense_Mutation_p.R97K|FSD2_uc010uom.1_Missense_Mutation_p.R97K	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	97										central_nervous_system(1)	1						AACCCCTGTTCTGGGTATGTT	0.468			NA											30	112					0	0	0.010818	0	0
KIF7	374654	broad.mit.edu	37	15	90173628	90173628	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:90173628G>A	uc002bof.2	-	16	3285	c.3208C>T	c.(3208-3210)CTT>TTT	p.L1070F	KIF7_uc010upw.1_Missense_Mutation_p.L556F|C15orf42_uc010upv.1_RNA	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1070					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GAGGCCCGAAGCACCCGCTGG	0.592			NA											3	33					0	0	0.004672	0	0
PKD1	5310	broad.mit.edu	37	16	2161870	2161870	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:2161870C>T	uc002cos.1	-	15	3507	c.3298G>A	c.(3298-3300)GAG>AAG	p.E1100K	PKD1_uc002cot.1_Missense_Mutation_p.E1100K	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1100	PKD 5.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGGAGGTACTCACCTGTGGGG	0.706			NA											7	29					0	0	0.006214	0	0
ITGAM	3684	broad.mit.edu	37	16	31309257	31309257	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:31309257C>G	uc002ebq.2	+	14	1787	c.1689C>G	c.(1687-1689)ATC>ATG	p.I563M	ITGAM_uc002ebr.2_Missense_Mutation_p.I564M|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	563	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GATCTGGCATCAGCCCCTCCC	0.557			NA											10	39					0	0	0.006214	0	0
MARVELD3	91862	broad.mit.edu	37	16	71674454	71674454	+	Missense_Mutation	SNP	C	C	T	rs140602857		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:71674454C>T	uc002fau.2	+	3	820	c.757C>T	c.(757-759)CGG>TGG	p.R253W	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane				skin(1)	1		Ovarian(137;0.125)				AGAGCAGGTTCGGCAGCTGGA	0.577			NA											23	90					0	0	0.005443	0	0
TCF25	22980	broad.mit.edu	37	16	89964965	89964965	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:89964965G>C	uc002fpb.2	+	10	1105	c.1023G>C	c.(1021-1023)AGG>AGC	p.R341S	TCF25_uc002fpc.2_Missense_Mutation_p.R106S	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	341					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TTGGATCTAGGAGCTTCTACC	0.577			NA											48	145					0	0	0.01441	0	0
SRR	63826	broad.mit.edu	37	17	2224685	2224685	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:2224685G>C	uc002fue.1	+	5	553	c.485G>C	c.(484-486)GGA>GCA	p.G162A	SRR_uc002fui.1_Missense_Mutation_p.G13A	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	162					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GTGATAGCTGGACAAGGGACA	0.413			NA											27	70					0	0	0.00632	0	0
ALOX15B	247	broad.mit.edu	37	17	7950584	7950584	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:7950584C>G	uc002gju.2	+	11	1582	c.1466C>G	c.(1465-1467)TCT>TGT	p.S489C	ALOX15B_uc002gjv.2_Missense_Mutation_p.S460C|ALOX15B_uc002gjw.2_Intron|ALOX15B_uc010vun.1_Intron|ALOX15B_uc010cnp.2_Missense_Mutation_p.S295C	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	489	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						AGCTTTGTCTCTGAAATCATC	0.532			NA											76	68					0	0	0.01441	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565946	18565946	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:18565946C>G	uc010vyd.1	-	5	1124	c.873G>C	c.(871-873)CAG>CAC	p.Q291H		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	291	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TATGAGTTCTCTGGTGTTTAG	0.403			NA											9	48					0	0	0.010729	0	0
KRT37	8688	broad.mit.edu	37	17	39579083	39579083	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:39579083G>A	uc002hwp.1	-	3	726	c.679C>T	c.(679-681)CAG>TAG	p.Q227*	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	227	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GACTCCTGCTGGGCCTCCAGG	0.667			NA											10	36					0	0	0.00245	0	0
CNTD1	124817	broad.mit.edu	37	17	40957871	40957872	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:40957871_40957872GG>CT	uc002ibm.3	+	4	781_782	c.549_550GG>CT	c.(547-552)CTGGCA>CTCTCA	p.A184S	CNTD1_uc010wha.1_Missense_Mutation_p.A101S	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	184										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCACTCCCCTGGCATATGTGGA	0.455			NA											13	43					0	0	0.004672	0	0
PPP1R9B	84687	broad.mit.edu	37	17	48217463	48217463	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:48217463C>T	uc002iqh.3	-	7	1864	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K		NM_032595	NP_115984	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	619	Interacts with TGN38 (By similarity).				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity				0						CCTACCTCCTCGTCATCCTCC	0.597			NA									OREG0024556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	17					0	0	0.00308	0	0
KIF2B	84643	broad.mit.edu	37	17	51902371	51902371	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:51902371G>C	uc002iua.2	+	1	2133	c.1977G>C	c.(1975-1977)CTG>CTC	p.L659L	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	659	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AAAAGAAACTGAAATTATTAC	0.458			NA											11	42					0	0	0.001855	0	0
BPTF	2186	broad.mit.edu	37	17	65850861	65850861	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:65850861G>A	uc002jgf.2	+	2	1480	c.1419G>A	c.(1417-1419)TTG>TTA	p.L473L	BPTF_uc002jge.2_Silent_p.L473L|BPTF_uc010wqm.1_Silent_p.L473L	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	473					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACTGGTTCTTGAACCGAAGAC	0.353			NA											8	47					0	0	0.004482	0	0
KIAA0195	9772	broad.mit.edu	37	17	73490824	73490824	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:73490824G>T	uc002jnz.3	+	19	2799	c.2524G>T	c.(2524-2526)GAT>TAT	p.D842Y	KIAA0195_uc010wsa.1_Missense_Mutation_p.D852Y|KIAA0195_uc010wsb.1_Missense_Mutation_p.D482Y|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	842					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGCCTCATTGATGGGCTTGT	0.577			NA											15	112					3.32936e-07	3.50888e-07	0.006122	1	0
GALK1	2584	broad.mit.edu	37	17	73754172	73754172	+	Missense_Mutation	SNP	G	G	C	rs111033608		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:73754172G>C	uc010wsi.1	-	8	1207	c.1144C>G	c.(1144-1146)CAA>GAA	p.Q382E	GALK1_uc002jpk.2_Missense_Mutation_p.Q382E	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	382					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCGGCTGCTTGAGAGAGGTAG	0.692			NA											19	54					0	0	0.010504	0	0
DSG3	1830	broad.mit.edu	37	18	29041325	29041325	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:29041325G>A	uc002kws.2	+	8	1058	c.949G>A	c.(949-951)GAA>AAA	p.E317K		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	317	Cadherin 3.|Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAATTGGTTTGAAATACAAAC	0.348			NA											22	75					0	0	0.008361	0	0
GALNT1	2589	broad.mit.edu	37	18	33243677	33243677	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:33243677G>A	uc010dmu.2	+	3	278	c.225G>A	c.(223-225)ATG>ATA	p.M75I	GALNT1_uc002kyz.3_Missense_Mutation_p.M15I|GALNT1_uc002kza.2_Missense_Mutation_p.M75I|GALNT1_uc002kzb.2_Missense_Mutation_p.M75I	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	75	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						AAGAAAAGATGAAAGAGATGT	0.378			NA											24	50					0	0	0.00278	0	0
IER3IP1	51124	broad.mit.edu	37	18	44683867	44683867	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:44683867C>A	uc002lcu.2	-	2	230	c.133G>T	c.(133-135)GAG>TAG	p.E45*		NM_016097	NP_057181	Q9Y5U9	IR3IP_HUMAN	immediate early response 3 interacting protein	45						endoplasmic reticulum membrane|Golgi apparatus|integral to membrane					0						ATTCCCGGCTCTTCTCCAAAT	0.393			NA											32	112					3.70713e-34	4.02542e-34	0.01441	1	0
ALPK2	115701	broad.mit.edu	37	18	56205245	56205245	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:56205245C>G	uc002lhj.3	-	5	2388	c.2174G>C	c.(2173-2175)AGA>ACA	p.R725T	ALPK2_uc002lhk.1_Missense_Mutation_p.R56T	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	725							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GTTGCCATCTCTGTCTTGTTT	0.458			NA											39	167					0	0	0.01441	0	0
ACSBG2	81616	broad.mit.edu	37	19	6183092	6183092	+	Silent	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:6183092C>G	uc002mef.1	+	10	1358	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	ACSBG2_uc002mee.1_Silent_p.L190L|ACSBG2_uc002meg.1_Silent_p.L377L|ACSBG2_uc002meh.1_Silent_p.L377L|ACSBG2_uc002mei.1_Silent_p.L327L|ACSBG2_uc010xiz.1_Silent_p.L377L	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	377					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						CTAAGACTCTCGTGTTCAGCA	0.498			NA											25	93					0	0	0.013726	0	0
FBN3	84467	broad.mit.edu	37	19	8201290	8201290	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:8201290C>T	uc002mjf.2	-	10	1348	c.1327G>A	c.(1327-1329)GTG>ATG	p.V443M		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	443	EGF-like 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TCGCCGCGCACGTCCTGGGTG	0.647			NA											4	71					0	0	0.009096	0	0
ZNF561	93134	broad.mit.edu	37	19	9721178	9721178	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:9721178G>A	uc002mlu.2	-	6	1364	c.1159C>T	c.(1159-1161)CAC>TAC	p.H387Y	ZNF561_uc010dwu.2_Missense_Mutation_p.H318Y|ZNF561_uc010xkr.1_Missense_Mutation_p.H251Y	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	387	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCTGTGTGAATTCTTGTA	0.403			NA											16	82					0	0	0.00499	0	0
COL5A3	50509	broad.mit.edu	37	19	10087239	10087239	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:10087239G>A	uc002mmq.1	-	45	3423	c.3337C>T	c.(3337-3339)CCC>TCC	p.P1113S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1113	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTCACCGGGGGACCTGGGTGT	0.532			NA											3	9					0	0	0.009096	0	0
RDH8	50700	broad.mit.edu	37	19	10127876	10127876	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:10127876G>C	uc002mmr.2	+	2	496	c.247G>C	c.(247-249)GAA>CAA	p.E83Q		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	83					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TATCCAGGGAGAAGTGGACGT	0.602			NA											14	28					0	0	0.007413	0	0
DHPS	1725	broad.mit.edu	37	19	12786738	12786738	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:12786738C>T	uc002muh.1	-	9	1121	c.1024G>A	c.(1024-1026)GAC>AAC	p.D342N	DHPS_uc002muf.1_Missense_Mutation_p.D219N|DHPS_uc002mug.1_Missense_Mutation_p.D300N|DHPS_uc002mui.1_Missense_Mutation_p.D295N|DHPS_uc002muj.1_Missense_Mutation_p.D286N|DHPS_uc002muk.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	342	NAD.			D->A: Strongly reduced NAD binding. Strongly reduced activity.	peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	AGGGAGGCGTCAGCATAGACC	0.607			NA									OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	43					0	0	0.010729	0	0
CACNA1A	773	broad.mit.edu	37	19	13395961	13395961	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:13395961C>T	uc010dze.2	-	21	3852	c.3616G>A	c.(3616-3618)GAG>AAG	p.E1206K	CACNA1A_uc010dzc.2_Missense_Mutation_p.E731K|CACNA1A_uc002mwy.3_Missense_Mutation_p.E1205K|CACNA1A_uc010xne.1_Missense_Mutation_p.E734K	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1206	Cytoplasmic (Potential).|Poly-Glu.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	tcgtcttcctcctcctccttc	0.458			NA											14	52					0	0	0.003163	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371821	19371821	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:19371821G>T	uc002nmb.2	-	3	340	c.285C>A	c.(283-285)TTC>TTA	p.F95L	HAPLN4_uc002nmc.2_Missense_Mutation_p.F95L	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	95	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			AGACGTCGGTGAAGGCCAGCG	0.692			NA											15	57					5.03518e-11	5.38589e-11	0.007413	1	0
ZNF607	84775	broad.mit.edu	37	19	38198843	38198843	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:38198843C>T	uc002ohc.1	-	4	803	c.207G>A	c.(205-207)GTG>GTA	p.V69V	ZNF607_uc002ohb.1_Silent_p.V68V	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TTTCTTCCCTCACAATCATCC	0.438			NA											15	58					0	0	0.006122	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610393	38610393	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:38610393C>T	uc002ohk.2	+	9	3248	c.2739C>T	c.(2737-2739)TGC>TGT	p.C913C		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	913					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACTGCTACTGCGGGGATGTCA	0.532			NA											5	141					0	0	0.000602	0	0
CNTD2	79935	broad.mit.edu	37	19	40730538	40730538	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:40730538G>C	uc010xvi.1	-	3	419	c.370C>G	c.(370-372)CTG>GTG	p.L124V	CNTD2_uc002ond.2_RNA	NM_024877	NP_079153	Q9H8S5	CNTD2_HUMAN	cyclin N-terminal domain containing 2 isoform 2	124					regulation of cyclin-dependent protein kinase activity		protein kinase binding				0						TCACCAGCCAGACCCAGGTAC	0.637			NA											11	36					0	0	0.00245	0	0
RTN2	6253	broad.mit.edu	37	19	45998252	45998252	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:45998252C>T	uc002pcb.2	-	3	319	c.91G>A	c.(91-93)GAC>AAC	p.D31N	RTN2_uc002pcc.2_Missense_Mutation_p.D31N|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	31						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		AAATCAGAGTCGTCGTTCCCT	0.622			NA											18	55					0	0	0.010504	0	0
LIN7B	64130	broad.mit.edu	37	19	49618206	49618206	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:49618206C>G	uc002pmp.2	+	2	182	c.138C>G	c.(136-138)TTC>TTG	p.F46L		NM_022165	NP_071448	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B	46	L27.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding				0		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		AGAGCCGCTTCTGCTCCGCTA	0.721			NA											4	8					0	0	0.001984	0	0
TMC4	147798	broad.mit.edu	37	19	54664081	54664081	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:54664081G>A	uc010erf.2	-	15	2233	c.2101C>T	c.(2101-2103)CGC>TGC	p.R701C	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.R415C|TMC4_uc002qdo.2_Missense_Mutation_p.R695C	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	701	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCACAGCGCGCCGTGCCAGG	0.567			NA											26	74					0	0	0.00632	0	0
ZNF583	147949	broad.mit.edu	37	19	56935705	56935705	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:56935705C>T	uc010ygl.1	+	5	1843	c.1678C>T	c.(1678-1680)CAG>TAG	p.Q560*	ZNF583_uc002qnc.2_Nonsense_Mutation_p.Q560*|ZNF583_uc010ygm.1_Nonsense_Mutation_p.Q560*	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		cacatcaaatcagttgccaag	0.104			NA											7	12					0	0	0.001984	0	0
ZNF544	27300	broad.mit.edu	37	19	58773458	58773458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:58773458C>T	uc010euo.2	+	7	1960	c.1486C>T	c.(1486-1488)CAG>TAG	p.Q496*	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Nonsense_Mutation_p.Q468*|ZNF544_uc010yhy.1_Nonsense_Mutation_p.Q468*|ZNF544_uc002qrt.3_Nonsense_Mutation_p.Q354*|ZNF544_uc002qru.3_Nonsense_Mutation_p.Q354*|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	496	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		CAAATGTACTCAGTGTGGGAA	0.448			NA											33	66					0	0	0.00623	0	0
ROCK2	9475	broad.mit.edu	37	2	11367475	11367475	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:11367475G>A	uc002rbd.1	-	6	1222	c.773C>T	c.(772-774)TCA>TTA	p.S258L		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	258	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AACCTCAGGTGATATATAATC	0.423			NA											38	222					0	0	0.01441	0	0
PUM2	23369	broad.mit.edu	37	2	20508167	20508167	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:20508167C>G	uc002rds.1	-	5	720	c.697G>C	c.(697-699)GAA>CAA	p.E233Q	PUM2_uc002rdt.1_Missense_Mutation_p.E233Q|PUM2_uc002rdr.2_Missense_Mutation_p.E172Q|PUM2_uc010yjy.1_Missense_Mutation_p.E233Q|PUM2_uc002rdu.1_Missense_Mutation_p.E233Q|PUM2_uc010yjz.1_Missense_Mutation_p.E172Q	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	233	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTAAGGATTCCAGACCAACT	0.433			NA											23	102					0	0	0.007291	0	0
KIF3C	3797	broad.mit.edu	37	2	26178520	26178520	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:26178520G>A	uc002rgu.2	-	3	2317	c.1660C>T	c.(1660-1662)CGG>TGG	p.R554W	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.R554W	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	554	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCATCTCCCGCTCACGACGT	0.602			NA											39	40					0	0	0.01441	0	0
SOS1	6654	broad.mit.edu	37	2	39224544	39224544	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:39224544C>G	uc002rrk.3	-	18	2855	c.2814G>C	c.(2812-2814)TTG>TTC	p.L938F	SOS1_uc002rrj.3_Missense_Mutation_p.L552F	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	938	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CTTCTGTTTTCAAGATATTAG	0.333			NA							Noonan_syndrome				14	50					0	0	0.006122	0	0
NRXN1	9378	broad.mit.edu	37	2	50724737	50724737	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:50724737G>T	uc010fbq.2	-	14	4210	c.2733C>A	c.(2731-2733)AGC>AGA	p.S911R	NRXN1_uc002rxb.3_Missense_Mutation_p.S543R|NRXN1_uc002rxe.3_Missense_Mutation_p.S871R|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TAAATGTCAAGCTCTGCAGGT	0.433			NA											7	39					5.18039e-06	5.3806e-06	0.00308	1	0
ZNF638	27332	broad.mit.edu	37	2	71650506	71650506	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:71650506C>G	uc002shx.2	+	22	4181	c.3862C>G	c.(3862-3864)CCC>GCC	p.P1288A	ZNF638_uc010yqw.1_Missense_Mutation_p.P867A|ZNF638_uc002shy.2_Missense_Mutation_p.P1288A|ZNF638_uc002shz.2_Missense_Mutation_p.P1288A|ZNF638_uc002sia.2_Missense_Mutation_p.P1288A|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.P385A|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1288	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ACCAGGAATTCCCACTGGGGA	0.368			NA											8	52					0	0	0.004482	0	0
NPHP1	4867	broad.mit.edu	37	2	110905540	110905540	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:110905540G>C	uc002tfn.3	-	13	1481	c.1387C>G	c.(1387-1389)CCA>GCA	p.P463A	NPHP1_uc002tfm.3_Missense_Mutation_p.P408A|NPHP1_uc002tfl.3_Missense_Mutation_p.P464A|NPHP1_uc002tfo.3_Missense_Mutation_p.P345A|NPHP1_uc010ywx.1_Missense_Mutation_p.P407A|NPHP1_uc010fjv.1_Missense_Mutation_p.P407A	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	463					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						CCAAGATCTGGAGATGCAGAA	0.318			NA											23	94					0	0	0.005443	0	0
PRPF40A	55660	broad.mit.edu	37	2	153530178	153530178	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:153530178C>G	uc002tyi.2	-	11	1168	c.1155G>C	c.(1153-1155)AAG>AAC	p.K385N	PRPF40A_uc002tyh.3_Missense_Mutation_p.K358N|PRPF40A_uc010zcd.1_Missense_Mutation_p.K305N|PRPF40A_uc002tyj.2_Missense_Mutation_p.K254N	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	385					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TGTATGTTTTCTTTGCTGGTT	0.299			NA											3	36					0	0	0.000602	0	0
TTC21B	79809	broad.mit.edu	37	2	166767949	166767949	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:166767949C>T	uc002udk.2	-	18	2482	c.2349G>A	c.(2347-2349)CTG>CTA	p.L783L		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	783	TPR 10.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						GTCCAGTTTTCAGAGCAGCTT	0.358			NA											17	61					0	0	0.010504	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802465	185802465	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:185802465C>T	uc002uph.2	+	4	2936	c.2342C>T	c.(2341-2343)TCA>TTA	p.S781L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	781						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TCTTATTCTTCAGATGAAAGT	0.373			NA											12	36					0	0	0.001855	0	0
ABCA12	26154	broad.mit.edu	37	2	215880343	215880343	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:215880343G>A	uc002vew.2	-	15	2047	c.1827C>T	c.(1825-1827)ATC>ATT	p.I609I	ABCA12_uc002vev.2_Silent_p.I291I|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	609					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGGGAGTGGTGATATTAGTAT	0.423	Ovarian(66;664 1488 5121 34295)		NA											20	24					0	0	0.00278	0	0
HDLBP	3069	broad.mit.edu	37	2	242206264	242206264	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:242206264C>G	uc002waz.2	-	3	249	c.21G>C	c.(19-21)TTG>TTC	p.L7F	HDLBP_uc002wba.2_Missense_Mutation_p.L7F|HDLBP_uc002wbb.2_Missense_Mutation_p.L28F|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	7					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCTCTTGGGTCAAAACTGCAA	0.443			NA											4	107					0	0	0.001984	0	0
UBOX5	22888	broad.mit.edu	37	20	3102754	3102754	+	Silent	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:3102754G>T	uc002whw.2	-	3	701	c.531C>A	c.(529-531)ATC>ATA	p.I177I	uc002whv.1_Intron|UBOX5_uc002whx.2_Silent_p.I177I|UBOX5_uc002why.1_Silent_p.I177I	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	177						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TCACATGGGTGATACAGATCC	0.582			NA											22	76					9.86323e-18	1.06563e-17	0.003954	1	0
PLCB1	23236	broad.mit.edu	37	20	8721083	8721083	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:8721083G>C	uc002wnb.2	+	22	2404	c.2401G>C	c.(2401-2403)GAC>CAC	p.D801H	PLCB1_uc010zrb.1_Missense_Mutation_p.D700H|PLCB1_uc002wna.2_Missense_Mutation_p.D801H|PLCB1_uc002wnc.1_Missense_Mutation_p.D700H|PLCB1_uc002wnd.1_Missense_Mutation_p.D378H	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	801					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTATGTGCCAGACACATATGC	0.408			NA											16	60					0	0	0.004007	0	0
REM1	28954	broad.mit.edu	37	20	30065669	30065669	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:30065669G>C	uc002wwa.2	+	3	663	c.379G>C	c.(379-381)GAC>CAC	p.D127H		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	127					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGATGGAGAAGACACCACACT	0.557			NA											9	27					0	0	0.010729	0	0
IGSF5	150084	broad.mit.edu	37	21	41142889	41142889	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr21:41142889G>C	uc002yyo.2	+	4	568	c.465G>C	c.(463-465)GAG>GAC	p.E155D		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	155	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				TAGTCGCTGAGAATGAACCTT	0.463			NA											12	50					0	0	0.00245	0	0
PWP2	5822	broad.mit.edu	37	21	45540973	45540973	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr21:45540973G>A	uc002zeb.2	+	13	1716	c.1626G>A	c.(1624-1626)CTG>CTA	p.L542L		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	542	WD 12.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CGCTGGCCCTGACCTCTGATG	0.607			NA											12	26					0	0	0.013537	0	0
CLTCL1	8218	broad.mit.edu	37	22	19222139	19222139	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:19222139G>A	uc002zpb.2	-	7	1135	c.1060C>T	c.(1060-1062)CGT>TGT	p.R354C	CLTCL1_uc011agv.1_Missense_Mutation_p.R354C|CLTCL1_uc011agw.1_Missense_Mutation_p.R354C	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	354	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					AGGTTACTACGAACGGCCAAA	0.483			NA	T	?	ALCL								10	114					0	0	0.008291	0	0
CSNK1E	1454	broad.mit.edu	37	22	38690475	38690475	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:38690475C>T	uc003avj.2	-	8	1212	c.951G>A	c.(949-951)ATG>ATA	p.M317I	CSNK1E_uc003avk.2_Missense_Mutation_p.M317I|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.M317I|CSNK1E_uc003avn.1_Missense_Mutation_p.M1I|CSNK1E_uc003avo.2_Missense_Mutation_p.M317I	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	317					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					GTAGCTGCCCCATCCTCTCCT	0.706	Esophageal Squamous(119;108 755 9651 12170 13692 17603 24932 28315 37982 41601)		NA											3	18					0	0	0.004672	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47290698	47290698	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:47290698C>T	uc003bib.2	+	7	991	c.856C>T	c.(856-858)CGC>TGC	p.R286C	TBC1D22A_uc010haf.2_Missense_Mutation_p.R256C|TBC1D22A_uc003bic.2_Missense_Mutation_p.R227C|TBC1D22A_uc003bie.2_Missense_Mutation_p.R208C|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.R239C	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	286	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		AGACATCCCTCGCATGAGCCC	0.507			NA											35	110					0	0	0.011902	0	0
MYRIP	25924	broad.mit.edu	37	3	40251560	40251560	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:40251560G>C	uc003cka.2	+	11	2016	c.1881G>C	c.(1879-1881)CAG>CAC	p.Q627H	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.Q627H|MYRIP_uc010hhw.2_Missense_Mutation_p.Q538H|MYRIP_uc011ayz.1_Missense_Mutation_p.Q440H|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	627	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACAACAGCCAGAGTGTCCAGG	0.507			NA											17	14					0	0	0.006122	0	0
LAMB2	3913	broad.mit.edu	37	3	49163465	49163465	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:49163465G>A	uc003cwe.2	-	17	2578	c.2279C>T	c.(2278-2280)TCT>TTT	p.S760F	LAMB2_uc003cwf.1_Missense_Mutation_p.S760F	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	760	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTCAGAGGGAGAAGTCTTGCT	0.597			NA											33	20					0	0	0.003755	0	0
NPRL2	10641	broad.mit.edu	37	3	50386409	50386409	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:50386409C>G	uc003daj.1	-	5	884	c.481G>C	c.(481-483)GAG>CAG	p.E161Q	NPRL2_uc003dai.1_Missense_Mutation_p.E41Q|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	161					negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						GGCCGCTGCTCAATCACCTTC	0.498			NA											49	65					0	0	0.01441	0	0
PDZRN3	23024	broad.mit.edu	37	3	73438989	73438989	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:73438989C>T	uc003dpl.1	-	7	1490	c.1394G>A	c.(1393-1395)CGA>CAA	p.R465Q	PDZRN3_uc011bgh.1_Missense_Mutation_p.R122Q|PDZRN3_uc010hoe.1_Missense_Mutation_p.R163Q|PDZRN3_uc011bgf.1_Missense_Mutation_p.R182Q|PDZRN3_uc011bgg.1_Missense_Mutation_p.R185Q	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	465	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTCTCCTTCTCGGATGCGCCC	0.478			NA											4	98					0	0	0.009096	0	0
PVRL3	25945	broad.mit.edu	37	3	110837719	110837719	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:110837719G>C	uc003dxt.1	+	3	719	c.719G>C	c.(718-720)AGA>ACA	p.R240T	PVRL3_uc003dxu.1_Missense_Mutation_p.R217T	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	240	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						AGATTTGCTAGAGGAAGGCGA	0.383			NA											45	45					0	0	0.01441	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	Colon(199;1504 1750 3362 26421 31210 32040)	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			24	29					0	0	0.007291	0	0
N4BP2	55728	broad.mit.edu	37	4	40121580	40121580	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:40121580G>C	uc003guy.3	+	9	2187	c.1849G>C	c.(1849-1851)GAA>CAA	p.E617Q	N4BP2_uc010ifq.2_Missense_Mutation_p.E537Q|N4BP2_uc010ifr.2_Missense_Mutation_p.E537Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	617						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TATTATCTCTGAAAAAGAAGA	0.308			NA											10	72					0	0	0.010729	0	0
N4BP2	55728	broad.mit.edu	37	4	40122548	40122548	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:40122548G>C	uc003guy.3	+	9	3155	c.2817G>C	c.(2815-2817)AAG>AAC	p.K939N	N4BP2_uc010ifq.2_Missense_Mutation_p.K859N|N4BP2_uc010ifr.2_Missense_Mutation_p.K859N	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	939						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AAAAACTAAAGACATTGGGTA	0.418			NA											12	46					0	0	0.003163	0	0
BMP2K	55589	broad.mit.edu	37	4	79808376	79808376	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:79808376C>G	uc003hlk.2	+	15	2166	c.2000C>G	c.(1999-2001)TCT>TGT	p.S667C	PAQR3_uc003hlm.2_RNA|PAQR3_uc003hln.2_RNA	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	667						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						GACTCACTTTCTGCTCCACAT	0.328			NA											4	26					0	0	0.000602	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192815	123192815	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:123192815C>G	uc003ieh.2	+	45	8181	c.8136C>G	c.(8134-8136)TTC>TTG	p.F2712L	KIAA1109_uc003iel.1_Missense_Mutation_p.F647L|KIAA1109_uc003iek.2_Missense_Mutation_p.F1331L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2712					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGCTTAACTTCTATTCACTTA	0.348			NA											6	50					0	0	0.001984	0	0
FAT4	79633	broad.mit.edu	37	4	126238505	126238505	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:126238505C>G	uc003ifj.3	+	1	939	c.939C>G	c.(937-939)TTC>TTG	p.F313L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	313	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCTGGACTTCGAAGCTCGGC	0.647			NA									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	45					0	0	0.008291	0	0
PCDH10	57575	broad.mit.edu	37	4	134073363	134073363	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:134073363G>A	uc003iha.2	+	1	2894	c.2068G>A	c.(2068-2070)GGG>AGG	p.G690R	PCDH10_uc003igz.2_Missense_Mutation_p.G690R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	690	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		gggcgggggcgggagcggagg	0.587			NA											22	35					0	0	0.00333	0	0
TLR2	7097	broad.mit.edu	37	4	154625613	154625613	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:154625613A>G	uc003inq.2	+	3	1773	c.1554A>G	c.(1552-1554)CAA>CAG	p.Q518Q	TLR2_uc003inr.2_Silent_p.Q518Q|TLR2_uc003ins.2_Silent_p.Q518Q	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	518	LRR 14.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CTAAGGAGCAACTTGACTCAT	0.428			NA											45	39					0	0	0.010771	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049273	36049273	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:36049273G>A	uc003jjz.1	-	4	654	c.561C>T	c.(559-561)TTC>TTT	p.F187F	UGT3A2_uc011cos.1_Silent_p.F153F|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	187	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCAAGGAACGGAATACTGGAA	0.463			NA											25	71					0	0	0.003954	0	0
SERINC5	256987	broad.mit.edu	37	5	79454754	79454754	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:79454754G>C	uc003kgj.2	-	8	1020	c.891C>G	c.(889-891)ATC>ATG	p.I297M	SERINC5_uc003kgk.2_Missense_Mutation_p.I295M|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.I297M|SERINC5_uc011ctj.1_Missense_Mutation_p.I297M	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	297	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		CAGGCACACAGATTGTAACAT	0.403			NA											5	95					0	0	0.00308	0	0
DDX46	9879	broad.mit.edu	37	5	134147433	134147433	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:134147433C>T	uc003kzw.2	+	18	2502	c.2334C>T	c.(2332-2334)TTC>TTT	p.F778F	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	778					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAAGGGATTCAAGTTTGATG	0.353	Colon(13;391 453 4901 21675 24897)		NA											15	58					0	0	0.006122	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214417	140214417	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:140214417C>G	uc003lhq.2	+	1	449	c.449C>G	c.(448-450)TCT>TGT	p.S150C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.S150C	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	150	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTTGACTCTCGGTTTCCA	0.552	NSCLC(160;258 2013 5070 22440 28951)		NA											3	33					0	0	0.00308	0	0
PCDHA9	9752	broad.mit.edu	37	5	140228529	140228529	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:140228529C>G	uc003lhu.2	+	1	1173	c.449C>G	c.(448-450)TCT>TGT	p.S150C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S150C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	150	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTTGACTCTCGGTTTCCA	0.542	Melanoma(55;1800 1972 14909)		NA											7	63					0	0	0.00499	0	0
DPYSL3	1809	broad.mit.edu	37	5	146777387	146777387	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:146777387C>T	uc003lon.1	-	12	1413	c.1303G>A	c.(1303-1305)GAA>AAA	p.E435K	DPYSL3_uc003loo.2_Missense_Mutation_p.E549K	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	435					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATCCCTTCAAAGATGTTG	0.567			NA											9	30					0	0	0.008291	0	0
GRIA1	2890	broad.mit.edu	37	5	153144112	153144112	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:153144112G>C	uc003lva.3	+	12	2307	c.1942G>C	c.(1942-1944)GAG>CAG	p.E648Q	GRIA1_uc003luy.3_Missense_Mutation_p.E648Q|GRIA1_uc003luz.3_Missense_Mutation_p.E553Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.E568Q|GRIA1_uc011dcx.1_Missense_Mutation_p.E579Q|GRIA1_uc011dcy.1_Missense_Mutation_p.E658Q|GRIA1_uc011dcz.1_Missense_Mutation_p.E658Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	648	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTCTCCCATTGAGAGTGCAGA	0.532			NA											3	54					0	0	0.004672	0	0
CDHR2	54825	broad.mit.edu	37	5	176002508	176002508	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:176002508G>A	uc003mem.1	+	10	836	c.770G>A	c.(769-771)GGA>GAA	p.G257E	CDHR2_uc003men.1_Missense_Mutation_p.G257E	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	257	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CCATTCCAGGGAACCTCGGTG	0.632			NA											6	146					0	0	0.001168	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032138	26032138	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:26032138C>G	uc003nfs.1	-	1	151	c.151G>C	c.(151-153)GAG>CAG	p.E51Q		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.E51Q(1)		ovary(2)	2						CGGCGGATCTCGCGCAGAGCC	0.627			NA											19	134					0	0	0.00278	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26124097	26124097	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:26124097C>T	uc003ngk.3	-	1	58	c.36G>A	c.(34-36)AAG>AAA	p.K12K	HIST1H2BC_uc003ngl.2_Silent_p.K12K|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	12					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						TGGAGCCCTTCTTCGGGGCGG	0.512			NA											23	115					0	0	0.005443	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782485	27782485	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:27782485G>A	uc003njn.1	-	1	34	c.34C>T	c.(34-36)CGC>TGC	p.R12C	HIST1H2BM_uc003njo.2_5'Flank	NM_021066	NP_066544	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	12					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCCTTGGCGCGAGCTTTGCCT	0.542			NA											8	66					0	0	0.004482	0	0
PGBD1	84547	broad.mit.edu	37	6	28251760	28251760	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:28251760G>A	uc003nky.2	+	2	540	c.170G>A	c.(169-171)GGA>GAA	p.G57E	PGBD1_uc003nkz.2_Missense_Mutation_p.G57E	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	57	SCAN box.				viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GAGGCTCACGGACCCCAGGAA	0.587			NA											23	56					0	0	0.00333	0	0
CDSN	1041	broad.mit.edu	37	6	31084746	31084746	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:31084746G>A	uc003nsm.1	-	2	673	c.646C>T	c.(646-648)CGT>TGT	p.R216C	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	216	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						CTACAGGGACGCTGGTTGGAG	0.607			NA											26	126					0	0	0.008361	0	0
TNXB	7148	broad.mit.edu	37	6	32023733	32023733	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:32023733C>T	uc003nzl.2	-	24	8564	c.8362G>A	c.(8362-8364)GAG>AAG	p.E2788K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2846	Fibronectin type-III 20.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACGGTGACCTCGCTCTCCTCG	0.687			NA											22	69					0	0	0.014323	0	0
SCUBE3	222663	broad.mit.edu	37	6	35210967	35210967	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:35210967G>A	uc003okf.1	+	15	1869	c.1863G>A	c.(1861-1863)CCG>CCA	p.P621P	SCUBE3_uc003okg.1_Silent_p.P620P|SCUBE3_uc003okh.1_Silent_p.P508P	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	621					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						GAGCAGAGCCGATGGAGTCCT	0.627			NA											23	78					0	0	0.005443	0	0
TEAD3	7005	broad.mit.edu	37	6	35444128	35444128	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:35444128C>T	uc003oku.3	-	9	913	c.677G>A	c.(676-678)CGG>CAG	p.R226Q	TEAD3_uc003okt.2_Missense_Mutation_p.R115Q|TEAD3_uc010jvx.2_Missense_Mutation_p.R166Q	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	226	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCCAGGAGCCGCAGCCGGGA	0.632			NA											17	49					0	0	0.007413	0	0
C6orf64	55776	broad.mit.edu	37	6	39082745	39082745	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:39082745G>C	uc003ook.1	-	1	121	c.121C>G	c.(121-123)CTA>GTA	p.L41V	C6orf64_uc011dty.1_RNA|C6orf64_uc003oom.1_RNA	NM_018322	NP_060792	Q9NPB0	CF064_HUMAN	hypothetical protein LOC55776	41	Ala-rich.					integral to membrane					0						GCTGCCTTTAGAGTCGCTGCT	0.667			NA											12	52					0	0	0.00245	0	0
AARS2	57505	broad.mit.edu	37	6	44278827	44278827	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:44278827C>T	uc010jza.1	-	4	656	c.653G>A	c.(652-654)TGT>TAT	p.C218Y	SPATS1_uc003oxg.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	218					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	ACAGGGCCCACAAGGGCCAGT	0.572			NA											4	128					0	0	0.001168	0	0
MUT	4594	broad.mit.edu	37	6	49421348	49421348	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:49421348G>C	uc003ozg.3	-	5	1288	c.1033C>G	c.(1033-1035)CTT>GTT	p.L345V		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	345					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTTAGAAGAAGAGATTTTGAG	0.303			NA											10	186					0	0	0.001855	0	0
FIG4	9896	broad.mit.edu	37	6	110113848	110113848	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:110113848G>A	uc003ptt.2	+	21	2655	c.2440G>A	c.(2440-2442)GAT>AAT	p.D814N	FIG4_uc011eau.1_Missense_Mutation_p.D537N	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	814					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTCAGAAGAAGATTTCTCCAT	0.313			NA											15	27					0	0	0.010504	0	0
KIF25	3834	broad.mit.edu	37	6	168430272	168430272	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:168430272T>A	uc003qwk.1	+	2	269	c.7T>A	c.(7-9)TGG>AGG	p.W3R	KIF25_uc010kkt.1_RNA|KIF25_uc003qwl.1_Missense_Mutation_p.W3R	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	3	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.W3C(1)		ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CCAGATGACATGGACCTCAGG	0.602			NA											4	92					0	0	0.009096	0	0
EIF3B	8662	broad.mit.edu	37	7	2409156	2409156	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:2409156G>A	uc003slx.2	+	10	1536	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	EIF3B_uc003sly.2_Missense_Mutation_p.E485K|EIF3B_uc003sma.2_Missense_Mutation_p.E213K	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	485					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTGGGTGCCTGAAGACAAAGA	0.473			NA											40	181					0	0	0.011902	0	0
GLCCI1	113263	broad.mit.edu	37	7	8110737	8110737	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:8110737G>A	uc003srk.2	+	6	1712	c.1153G>A	c.(1153-1155)GAT>AAT	p.D385N		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	385											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CTCAACAGAAGATTTGCTCTA	0.473			NA											26	117					0	0	0.013726	0	0
FAM188B	84182	broad.mit.edu	37	7	30831131	30831131	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:30831131G>C	uc003tbt.2	+	5	1091	c.1014G>C	c.(1012-1014)ATG>ATC	p.M338I	FAM188B_uc010kwe.2_Missense_Mutation_p.M309I	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	338											0						ATTCCAGGATGACCCAGGAGA	0.587			NA											13	36					0	0	0.003163	0	0
ZNF735	730291	broad.mit.edu	37	7	63680216	63680216	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:63680216C>T	uc011kdn.1	+	4	787	c.787C>T	c.(787-789)CAC>TAC	p.H263Y		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	263	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGAGAATTCACACTGGAGA	0.443			NA											5	30					0	0	0.000602	0	0
GTF2I	2969	broad.mit.edu	37	7	74173158	74173158	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:74173158C>A	uc003uau.2	+	34	3357	c.2987C>A	c.(2986-2988)CCC>CAC	p.P996H	GTF2I_uc003uav.2_Missense_Mutation_p.P975H|GTF2I_uc003uaw.2_Missense_Mutation_p.P976H|GTF2I_uc003uay.2_Missense_Mutation_p.P974H|GTF2I_uc003uax.2_Missense_Mutation_p.P955H|GTF2I_uc003uba.2_Missense_Mutation_p.P187H	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	996					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						GAACCAGACCCCACGTGGTAG	0.468			NA											3	75					7.48243e-07	7.80933e-07	0.006214	1	0
COL1A2	1278	broad.mit.edu	37	7	94029590	94029590	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:94029590G>A	uc003ung.1	+	5	686	c.215G>A	c.(214-216)GGT>GAT	p.G72D	COL1A2_uc011kib.1_Missense_Mutation_p.G72D	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	72					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGCCCCCCTGGTCTCGGTGGG	0.488			NA								HNSCC(75;0.22)			4	85					0	0	0.000602	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518581	113518581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:113518581G>A	uc010ljy.1	-	4	2597	c.2566C>T	c.(2566-2568)CAA>TAA	p.Q856*		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	856					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GTTGCTTTTTGATATTCTGTA	0.373			NA											25	116					0	0	0.00632	0	0
MDFIC	29969	broad.mit.edu	37	7	114655893	114655893	+	Silent	SNP	T	T	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:114655893T>C	uc003vhf.2	+	5	1235	c.972T>C	c.(970-972)CCT>CCC	p.P324P		NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	215	Cys-rich.				activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						GTAACTGCCCTTGTGATATGG	0.463			NA											4	265					0	0	0.001168	0	0
LOC407835	407835	broad.mit.edu	37	7	128767312	128767312	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:128767312G>A	uc003voo.2	+	1	988	c.741G>A	c.(739-741)TCG>TCA	p.S247S		NR_002144				SubName: Full=cDNA FLJ35806 fis, clone TESTI2005987, highly similar to Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2); SubName: Full=Mitogen-activated protein kinase kinase 2, isoform CRA_d;												0						CGGTGCAGTCGGTCATCTGGA	0.642			NA											2	3					0	0	0.009096	0	0
C7orf45	136263	broad.mit.edu	37	7	129847761	129847761	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:129847761T>C	uc003vpp.2	+	1	58	c.11T>C	c.(10-12)CTT>CCT	p.L4P	TMEM209_uc003vpn.2_5'Flank|TMEM209_uc010lmc.1_5'Flank|TMEM209_uc003vpo.2_5'Flank	NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	4						integral to membrane					0	Melanoma(18;0.0435)					ATGGGAGACCTTTTTTCCTTA	0.413			NA											3	107					0	0	0.001168	0	0
PLXNA4	91584	broad.mit.edu	37	7	131817925	131817925	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:131817925G>A	uc003vra.3	-	31	5701	c.5472C>T	c.(5470-5472)ATC>ATT	p.I1824I	PLXNA4_uc003vqz.3_Silent_p.I109I	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1824	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTTGGTCGCTGATGGCTGGCA	0.507			NA											30	124					0	0	0.006999	0	0
PRKDC	5591	broad.mit.edu	37	8	48719862	48719862	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:48719862C>T	uc003xqi.2	-	70	9640	c.9583G>A	c.(9583-9585)GAG>AAG	p.E3195K	PRKDC_uc003xqj.2_Missense_Mutation_p.E3195K|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3195	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GTAAGCTTCTCCTCTATTTTG	0.418	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					53	97					0	0	0.01441	0	0
PCMTD1	115294	broad.mit.edu	37	8	52733136	52733136	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:52733136C>G	uc003xqx.3	-	6	1190	c.849G>C	c.(847-849)CAG>CAC	p.Q283H	PCMTD1_uc011ldm.1_Missense_Mutation_p.Q153H|PCMTD1_uc003xqw.3_Missense_Mutation_p.Q283H|PCMTD1_uc011ldn.1_Missense_Mutation_p.Q95H|PCMTD1_uc010lya.2_Missense_Mutation_p.Q207H	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	283						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TGTTAATTCTCTGTTTAACTC	0.323			NA											6	246					0	0	0.006214	0	0
C8orf47	203111	broad.mit.edu	37	8	99102182	99102182	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:99102182C>T	uc003yih.1	+	2	1085	c.937C>T	c.(937-939)CGA>TGA	p.R313*		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	313	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GCATCCAGCACGAAATGTAGA	0.443			NA											29	146					0	0	0.004289	0	0
RIMS2	9699	broad.mit.edu	37	8	105261043	105261043	+	Splice_Site	SNP	T	T	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:105261043T>A	uc003yls.2	+	25	3884	c.3643_splice	c.e25+2	p.G1215_splice	RIMS2_uc003ylp.2_Splice_Site_p.G1197_splice|RIMS2_uc003ylw.2_Splice_Site_p.G1204_splice|RIMS2_uc003ylq.2_Splice_Site_p.G1011_splice|RIMS2_uc003ylr.2_Splice_Site_p.G1036_splice	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2						intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTGCAATGGGTAAGAATTTCT	0.383			NA								HNSCC(12;0.0054)			5	101					0	0	0.001168	0	0
LRP12	29967	broad.mit.edu	37	8	105511743	105511743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:105511743G>A	uc003yma.2	-	4	372	c.277C>T	c.(277-279)CAG>TAG	p.Q93*	LRP12_uc003ymb.2_Nonsense_Mutation_p.Q74*	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	93	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCAAAATCCTGAAAACTGAAA	0.299			NA											6	55					0	0	0.001984	0	0
DENND3	22898	broad.mit.edu	37	8	142178249	142178249	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:142178249C>G	uc003yvy.2	+	13	1938	c.1660C>G	c.(1660-1662)CTG>GTG	p.L554V	DENND3_uc010mep.2_Missense_Mutation_p.L515V|DENND3_uc003yvz.1_Missense_Mutation_p.L238V	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	554										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CGATAACTCTCTGCTCCTGGC	0.542			NA											93	168					0	0	0.01441	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957662	143957662	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:143957662C>G	uc003yxi.2	-	5	956	c.949G>C	c.(949-951)GAC>CAC	p.D317H	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_5'UTR|CYP11B1_uc003yxj.2_Missense_Mutation_p.D317H|CYP11B1_uc010mey.2_Missense_Mutation_p.D388H	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	317					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTGACCGTGTCCACGCTCCCT	0.617			NA							Familial_Hyperaldosteronism_type_I				29	79					0	0	0.003755	0	0
PTCH1	5727	broad.mit.edu	37	9	98244475	98244475	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr9:98244475A>G	uc004avk.3	-	4	783	c.595T>C	c.(595-597)TTG>CTG	p.L199L	PTCH1_uc010mro.2_Silent_p.L48L|PTCH1_uc010mrp.2_Silent_p.L48L|PTCH1_uc010mrq.2_Silent_p.L48L|PTCH1_uc004avl.3_Silent_p.L48L|PTCH1_uc010mrr.2_Silent_p.L133L|PTCH1_uc004avm.3_Silent_p.L198L|PTCH1_uc010mrs.1_5'Flank|PTCH1_uc010mrt.1_RNA|PTCH1_uc010mru.1_Intron|PTCH1_uc004avo.2_Silent_p.L133L|PTCH1_uc010mrv.1_RNA	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	199	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAATGTTCCAATTTCCACTGC	0.269			NA							Basal_Cell_Nevus_syndrome				10	17					0	0	0.008291	0	0
C9orf156	51531	broad.mit.edu	37	9	100667199	100667199	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr9:100667199G>A	uc004axv.1	-	5	1219	c.1142C>T	c.(1141-1143)GCG>GTG	p.A381V	C9orf156_uc004axw.1_Missense_Mutation_p.A278V|C9orf156_uc004axx.1_Missense_Mutation_p.A235V	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	381					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CCGAGGATCCGCTGACAGCAC	0.473			NA											3	57					0	0	0.004672	0	0
SFRS17A	8227	broad.mit.edu	37	X	1714321	1714321	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:1714321G>C	uc004cqa.2	+	3	1003	c.807G>C	c.(805-807)AAG>AAC	p.K269N	SFRS17A_uc010ncx.1_Missense_Mutation_p.K269N|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	269					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTCAATTAAGAAGCGGCAGC	0.517			NA											33	150					0	0	0.012213	0	0
TLR7	51284	broad.mit.edu	37	X	12906731	12906731	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:12906731C>G	uc004cvc.2	+	3	3243	c.3104C>G	c.(3103-3105)ACA>AGA	p.T1035R		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	1035	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	GCCCTGGCCACAGACAATCAT	0.517			NA											16	193					0	0	0.008871	0	0
ACE2	59272	broad.mit.edu	37	X	15605910	15605910	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:15605910G>C	uc004cxa.1	-	6	936	c.768C>G	c.(766-768)ATC>ATG	p.I256M	ACE2_uc004cxb.2_Missense_Mutation_p.I256M	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	256	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CAATTGGACTGATATAGGAAG	0.388			NA											10	201					0	0	0.004007	0	0
PPEF1	5475	broad.mit.edu	37	X	18725777	18725777	+	Splice_Site	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:18725777G>C	uc004cyq.2	+	4	360	c.-121_splice	c.e4-1		PPEF1_uc004cyp.2_Splice_Site|PPEF1_uc004cyr.2_Splice_Site|PPEF1_uc004cys.2_5'UTR|PPEF1_uc011mja.1_5'Flank	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					TTCCTCATTAGAATCTATGAC	0.458			NA											3	8					0	0	0.004672	0	0
MTMR8	55613	broad.mit.edu	37	X	63445233	63445233	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:63445233C>G	uc011mou.1	-	10	1491	c.1423G>C	c.(1423-1425)GAC>CAC	p.D475H	ASB12_uc004dvp.1_Missense_Mutation_p.D91H|ASB12_uc004dvq.1_Missense_Mutation_p.D100H|ASB12_uc004dvr.1_Missense_Mutation_p.D100H	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						TCCAAGCTGTCAACATCAGCA	0.552			NA											3	20					0	0	0.009096	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465569	70465569	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:70465569C>A	uc004dzh.1	-	17	2896	c.2809G>T	c.(2809-2811)GAA>TAA	p.E937*	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Nonsense_Mutation_p.E937*|ZMYM3_uc004dzj.1_Nonsense_Mutation_p.E925*	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	937					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GCAATCATTTCTGCCATAGCC	0.527			NA											7	41					0.00307968	0.00313806	0.00308	1	0
ACRC	93953	broad.mit.edu	37	X	70823512	70823512	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:70823512G>A	uc004eae.2	+	8	886	c.385G>A	c.(385-387)GAC>AAC	p.D129N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	129	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					TGATGACAATGACGATGACAA	0.448			NA											54	181					0	0	0.01441	0	0
TAF7L	54457	broad.mit.edu	37	X	100533109	100533109	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:100533109A>T	uc004ehb.2	-	8	775	c.763T>A	c.(763-765)TAC>AAC	p.Y255N	TAF7L_uc004eha.2_Missense_Mutation_p.Y169N|TAF7L_uc004ehc.1_Missense_Mutation_p.Y169N	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	255					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						GATTCAATGTACTGAAGCAAA	0.433	Ovarian(104;431 1530 3210 15406 18594)		NA											5	78					0	0	0.001984	0	0
MMEL1	79258	broad.mit.edu	37	1	2560819	2560821	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	CAG	CAG	-	-	CAG	CAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:2560819_2560821delCAG	uc001ajy.2	-	2	317_319	c.103_105delCTG	c.(103-105)CTGdel	p.L35del	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	35	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGCGGTCACcagcagcagcagc	0.665			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
WWP2	11060	broad.mit.edu	37	16	69833132	69833132	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:69833132delA	uc002exu.1	+	5	363	c.274delA	c.(274-276)AGAfs	p.R92fs	WWP2_uc002ext.2_Frame_Shift_Del_p.R92fs|WWP2_uc002exv.1_Frame_Shift_Del_p.R92fs	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	92	C2.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						CCATACCTTGAGAAATGAACT	0.453			NA									OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	71	---	---	---	---	NA	NA	NA	NA	NA
IFI35	3430	broad.mit.edu	37	17	41164281	41164281	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:41164281delC	uc010whj.1	+	2	303	c.107delC	c.(106-108)TCCfs	p.S36fs		NM_005533	NP_005524	P80217	IN35_HUMAN	interferon-induced protein 35	36					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			ovary(1)	1		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		CTCGGGGACTCCCCCAAAGAC	0.463			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
CNDP2	55748	broad.mit.edu	37	18	72167216	72167221	+	In_Frame_Del	DEL	CCCTCA	CCCTCA	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	CCCTCA	CCCTCA	-	-	CCCTCA	CCCTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:72167216_72167221delCCCTCA	uc002llm.1	+	2	170_175	c.8_13delCCCTCA	c.(7-15)GCCCTCACT>GCT	p.LT4del	CNDP2_uc002lln.1_In_Frame_Del_p.LT4del|CNDP2_uc002llo.2_In_Frame_Del_p.LT4del	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	4_5						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AAGATGGCGGCCCTCACTACCCTGTT	0.466			NA											12	62	---	---	---	---	NA	NA	NA	NA	NA
MEGF8	1954	broad.mit.edu	37	19	42880807	42880808	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:42880807_42880808delGC	uc002otl.3	+	41	8852_8853	c.8217_8218delGC	c.(8215-8220)CTGCGGfs	p.L2739fs	MEGF8_uc002otm.3_Frame_Shift_Del_p.L2347fs|MEGF8_uc002otn.3_Frame_Shift_Del_p.L400fs	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2806_2807	Gly-rich.|Cytoplasmic (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TCGTCACACTGCGGCACAGGCT	0.688			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
BAP1	8314	broad.mit.edu	37	3	52437500	52437500	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:52437500delC	uc003ddx.2	-	13	1776	c.1661delG	c.(1660-1662)GGTfs	p.G554fs	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	554					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GATGACAGGACCCAGATCACG	0.607	GBM(101;493 1458 7992 21037 25532)		NA	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								77	32	---	---	---	---	NA	NA	NA	NA	NA
