Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NISCH	11188	broad.mit.edu	37	3	52521842	52521842	+	Silent	SNP	G	G	T	rs150301138		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr3:52521842G>T	ENST00000345716.4	+	16	2468	c.2334G>T	c.(2332-2334)ctG>ctT	p.L778L	NISCH_ENST00000479054.1_Silent_p.L778L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	778	Interaction with ITGA5 (By similarity).|Interaction with LIMK (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGCCGGAGCTGTGTCTGGTGC	0.597000													11	23					0.0809354	0.0859938	1	1	0
ACOT12	134526	broad.mit.edu	37	5	80643655	80643655	+	Silent	SNP	G	G	A	rs149420016		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr5:80643655G>A	ENST00000307624.3	-	6	619	c.591C>T	c.(589-591)caC>caT	p.H197H		NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	197	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		ATGTATTTCCGTGATGGTTTG	0.488000													82	146					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76457712	76457712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr17:76457712G>A	ENST00000389840.5	-	58	9335	c.9211C>T	c.(9211-9213)Cag>Tag	p.Q3071*	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Nonsense_Mutation_p.Q3080*					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCGACCACCTGGATCAGTTGG	0.527000													5	12					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			47	49					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	46					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219247721	219247721	+	Missense_Mutation	SNP	G	G	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr2:219247721G>T	ENST00000233202.6	+	2	386	c.46G>T	c.(46-48)Ggt>Tgt	p.G16C	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	16	Pro/Ser-rich.				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCCAGCTATGGTTCCATCTc	0.597000													3	29					6.4e-05	7.25333e-05	1	1	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													4	77					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182784164	182784164	+	Silent	SNP	C	C	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr2:182784164C>T	ENST00000431877.2	+	14	3314	c.3135C>T	c.(3133-3135)tcC>tcT	p.S1045S	SSFA2_ENST00000409001.1_Silent_p.S1045S|SSFA2_ENST00000428267.2_Silent_p.S892S|SSFA2_ENST00000409136.1_Silent_p.S554S|SSFA2_ENST00000320370.7_Silent_p.S1045S|SSFA2_ENST00000467172.2_3'UTR	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	1045						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCCGCTCCTCCGCACTCATGG	0.527000													4	116					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148004602	148004602	+	Missense_Mutation	SNP	C	C	A			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr1:148004602C>A	ENST00000369219.1	-	22	2728	c.2712G>T	c.(2710-2712)ttG>ttT	p.L904F				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	904	NBPF 10.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					TTGTCACCGTCAAAGTAAAAA	0.468000													19	212					1.75199e-13	2.29106e-13	1	1	0
MEFV	4210	broad.mit.edu	37	16	3293588	3293588	+	Silent	SNP	C	C	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr16:3293588C>T	ENST00000219596.1	-	10	1938	c.1899G>A	c.(1897-1899)ccG>ccA	p.P633P	MEFV_ENST00000339854.4_Silent_p.P453P|MEFV_ENST00000536379.1_Silent_p.P422P|MEFV_ENST00000541159.1_3'UTR	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	633	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	CAAATCTTTGCGGGCCATCAG	0.517000													7	219					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100961724	100961724	+	Missense_Mutation	SNP	G	G	C			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr9:100961724G>C	ENST00000375066.5	-	13	2784	c.2693C>G	c.(2692-2694)tCc>tGc	p.S898C	TBC1D2_ENST00000375064.1_3'UTR|TBC1D2_ENST00000342112.5_Missense_Mutation_p.S691C|TBC1D2_ENST00000375063.1_Missense_Mutation_p.S449C	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	909						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		TCTGCGCCGGGATGCCCGCCT	0.677000													6	97					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100961724	100961724	+	Missense_Mutation	SNP	G	G	C			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr9:100961724G>C	ENST00000375066.5	-	13	2784	c.2693C>G	c.(2692-2694)tCc>tGc	p.S898C	TBC1D2_ENST00000375064.1_3'UTR|TBC1D2_ENST00000375063.1_Missense_Mutation_p.S449C|TBC1D2_ENST00000342112.5_Missense_Mutation_p.S691C	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	909						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		TCTGCGCCGGGATGCCCGCCT	0.677000													6	97					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52521842	52521842	+	Silent	SNP	G	G	T	rs150301138		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr3:52521842G>T	ENST00000345716.4	+	16	2468	c.2334G>T	c.(2332-2334)ctG>ctT	p.L778L	NISCH_ENST00000479054.1_Silent_p.L778L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	778	Interaction with ITGA5 (By similarity).|Interaction with LIMK (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGCCGGAGCTGTGTCTGGTGC	0.597000													11	23					0.0809354	0.0809354	1	1	0
MEFV	4210	broad.mit.edu	37	16	3293588	3293588	+	Silent	SNP	C	C	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr16:3293588C>T	ENST00000219596.1	-	10	1938	c.1899G>A	c.(1897-1899)ccG>ccA	p.P633P	MEFV_ENST00000339854.4_Silent_p.P453P|MEFV_ENST00000536379.1_Silent_p.P422P|MEFV_ENST00000541159.1_3'UTR	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	633	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	CAAATCTTTGCGGGCCATCAG	0.517000													7	219					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80643655	80643655	+	Silent	SNP	G	G	A	rs149420016		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr5:80643655G>A	ENST00000307624.3	-	6	619	c.591C>T	c.(589-591)caC>caT	p.H197H		NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	197	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		ATGTATTTCCGTGATGGTTTG	0.488000													82	146					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76457712	76457712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr17:76457712G>A	ENST00000389840.5	-	58	9335	c.9211C>T	c.(9211-9213)Cag>Tag	p.Q3071*	DNAH17_ENST00000585328.1_Nonsense_Mutation_p.Q3080*|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCGACCACCTGGATCAGTTGG	0.527000													5	12					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			47	49					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219247721	219247721	+	Missense_Mutation	SNP	G	G	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr2:219247721G>T	ENST00000233202.6	+	2	386	c.46G>T	c.(46-48)Ggt>Tgt	p.G16C	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	16	Pro/Ser-rich.				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCCAGCTATGGTTCCATCTc	0.597000													3	29					6.4e-05	7.25333e-05	1	1	0
SSFA2	6744	broad.mit.edu	37	2	182784164	182784164	+	Silent	SNP	C	C	T			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr2:182784164C>T	ENST00000431877.2	+	14	3314	c.3135C>T	c.(3133-3135)tcC>tcT	p.S1045S	SSFA2_ENST00000409136.1_Silent_p.S554S|SSFA2_ENST00000467172.2_3'UTR|SSFA2_ENST00000320370.7_Silent_p.S1045S|SSFA2_ENST00000428267.2_Silent_p.S892S|SSFA2_ENST00000409001.1_Silent_p.S1045S	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	1045						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCCGCTCCTCCGCACTCATGG	0.527000													4	116					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	80					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148004602	148004602	+	Missense_Mutation	SNP	C	C	A			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr1:148004602C>A	ENST00000369219.1	-	22	2728	c.2712G>T	c.(2710-2712)ttG>ttT	p.L904F				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	904	NBPF 10.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					TTGTCACCGTCAAAGTAAAAA	0.468000													19	212					1.75199e-13	2.12741e-13	1	1	0
PRG4	10216	broad.mit.edu	37	1	186274011	186274012	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr1:186274011_186274012insAA	ENST00000445192.2	+	6	600_601	c.555_556insAA	c.(553-558)tcaaaafs	p.SK185fs	PRG4_ENST00000367485.4_Intron|PRG4_ENST00000367486.3_Intron|PRG4_ENST00000367483.4_Frame_Shift_Ins_p.SK144fs|PRG4_ENST00000367484.3_Frame_Shift_Ins_p.SK144fs	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	185	Ser-rich.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TCAAGTCTTCCAAAAATTCAGC	0.337													38	65	---	---	---	---					
RP11-360K13.1	0	broad.mit.edu	37	11	96514998	96514999	+	RNA	INS	-	-	A	rs112766481		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr11:96514998_96514999insA	ENST00000527528.1	+	0	158																											GCTTAGTTATTaaaaaaaaaaa	0.366													3	6	---	---	---	---					
JPH4	84502	broad.mit.edu	37	14	24046493	24046493	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr14:24046493delC	ENST00000397118.3	-	3	1072	c.170delG	c.(169-171)gcfs	p.G58fs	JPH4_ENST00000356300.4_Frame_Shift_Del_p.G58fs	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	58					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GCTGTGTCCGCCGGGCCCCGT	0.731													2	4	---	---	---	---					
NKD1	85407	broad.mit.edu	37	16	50664747	50664747	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr16:50664747delC	ENST00000268459.3	+	8	845	c.621delC	c.(619-621)agfs	p.S207fs		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	207					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		ACCTGCAGAGCGCAAGGCCCC	0.652													2	4	---	---	---	---					
WDR18	57418	broad.mit.edu	37	19	990349	990349	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	ce04400e-4148-4408-a9f5-a4ddaca639f9	g.chr19:990349delG	ENST00000251289.5	+	4	605	c.582delG	c.(580-582)ctfs	p.L194fs	WDR18_ENST00000587001.2_Frame_Shift_Del_p.L194fs	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	194										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCTCACTGGACCAGACGG	0.701													3	5	---	---	---	---					
PRG4	10216	broad.mit.edu	37	1	186274011	186274012	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr1:186274011_186274012insAA	ENST00000445192.2	+	6	600_601	c.555_556insAA	c.(553-558)tcaaaafs	p.SK185fs	PRG4_ENST00000367486.3_Intron|PRG4_ENST00000367485.4_Intron|PRG4_ENST00000367483.4_Frame_Shift_Ins_p.SK144fs|PRG4_ENST00000367484.3_Frame_Shift_Ins_p.SK144fs	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	185	Ser-rich.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TCAAGTCTTCCAAAAATTCAGC	0.337													38	65	---	---	---	---					
CASP8AP2	9994	broad.mit.edu	37	6	90556398	90556398	+	RNA	DEL	T	T	-			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr6:90556398delT	ENST00000551025.1	+	0	1492							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TCTAAtttccttttttttttt	0.418													2	4	---	---	---	---					
NKD1	85407	broad.mit.edu	37	16	50664747	50664747	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr16:50664747delC	ENST00000268459.3	+	8	845	c.621delC	c.(619-621)agfs	p.S207fs		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	207					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		ACCTGCAGAGCGCAAGGCCCC	0.652													2	4	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21142441	21142442	+	RNA	INS	-	-	A	rs71715453		TCGA-P8-A5KD-01A-11D-A35D-08	TCGA-P8-A5KD-11A-11D-A35D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d6d1ab98-19a0-40b0-ba01-e55a51c61b0d	d985c4ed-4c78-44f0-9254-35266677f568	g.chr20:21142441_21142442insA	ENST00000591761.1	-	0	5142				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							TTCATTTCTGGAAAAAAAAAAA	0.366													3	4	---	---	---	---					
