Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-69H14.6	0	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													5	496					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18915370	18915370	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chrX:18915370C>T	ENST00000379942.4	-	30	3858	c.3193G>A	c.(3193-3195)Ggc>Agc	p.G1065S		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1065	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					AGCCACTGGCCCTGCCGCTCA	0.622000													6	122					0	0	1	0	0
CHEK2P2	0	broad.mit.edu	37	15	20496770	20496770	+	RNA	SNP	T	T	C	rs3865047	by1000genomes	TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr15:20496770T>C	ENST00000555186.1	+	0	823					NR_038836.1																						TTATAGTGTGTATTTTAATTA	0.353000													5	44					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	30					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			52	58					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869931	97869931	+	Missense_Mutation	SNP	A	A	T	rs76309140		TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr2:97869931A>T	ENST00000420699.2	+	50	3236	c.2992A>T	c.(2992-2994)Aca>Tca	p.T998S	ANKRD36_ENST00000461153.2_Missense_Mutation_p.T998S	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	998								p.T998S(13)		endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CATTCAGGCTACAAGTGATGA	0.289000													5	41					0	0	1	0	0
ZNF275	10838	broad.mit.edu	37	X	152613127	152613127	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chrX:152613127G>T	ENST00000421401.3	+	4	1161	c.984G>T	c.(982-984)aaG>aaT	p.K328N	ZNF275_ENST00000440091.1_Missense_Mutation_p.K358N|ZNF275_ENST00000370251.2_Intron|ZNF275_ENST00000370249.2_Missense_Mutation_p.K275N	NM_001080485.3	NP_001073954.3	A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	244						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGCGGCAAGGCCTTCCGCC	0.692000													7	39					0.000274275	0.000281688	1	1	0
THUMPD2	80745	broad.mit.edu	37	2	39997221	39997221	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr2:39997221C>A	ENST00000505747.1	-	3	328	c.301G>T	c.(301-303)Gat>Tat	p.D101Y	THUMPD2_ENST00000260619.6_Missense_Mutation_p.D71Y|THUMPD2_ENST00000454352.2_Missense_Mutation_p.D71Y|THUMPD2_ENST00000403537.3_5'UTR	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	101							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				CTTCCTGGATCTTCATTTATA	0.289000													6	57					3.59834e-05	4.02167e-05	1	1	0
CUX2	23316	broad.mit.edu	37	12	111729283	111729283	+	Silent	SNP	T	T	C			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr12:111729283T>C	ENST00000261726.6	+	5	517	c.363T>C	c.(361-363)ttT>ttC	p.F121F		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	121						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CCCCCAGCTTTGACCCCAGTG	0.627000													4	75					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49071913	49071913	+	Silent	SNP	G	G	A			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chrX:49071913G>A	ENST00000376265.2	-	28	3421	c.3360C>T	c.(3358-3360)taC>taT	p.Y1120Y	CACNA1F_ENST00000376251.1_Silent_p.Y1055Y|CACNA1F_ENST00000323022.5_Silent_p.Y1109Y	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1120	Dihydropyridine binding (By similarity).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TGATGATGATGTAGACAATGA	0.493000													16	22					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414331	20414331	+	Silent	SNP	G	G	A	rs10964556		TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr9:20414331G>A	ENST00000380338.4	-	5	799	c.513C>T	c.(511-513)agC>agT	p.S171S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S168S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	171	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctgctgctgc	0.537000			T	MLL	ALL								5	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076861	9076861	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr19:9076861C>T	ENST00000397910.4	-	3	10788	c.10585G>A	c.(10585-10587)Gac>Aac	p.D3529N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3530	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGTTACGTCCAGGATGCTC	0.517000													46	173					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109384207	109384207	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr2:109384207G>A	ENST00000283195.6	+	20	7338	c.7212G>A	c.(7210-7212)tgG>tgA	p.W2404*		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2404	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TATGGTTGTGGACTGCATGTG	0.368000													50	831					0	0	1	0	0
ZBTB14	7541	broad.mit.edu	37	18	5291780	5291780	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr18:5291780T>G	ENST00000357006.4	-	4	765	c.427A>C	c.(427-429)Aag>Cag	p.K143Q	ZBTB14_ENST00000400143.3_Missense_Mutation_p.K143Q	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		AGGCAATACTTACTTTTGGAC	0.448000													47	136					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52448551	52448551	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr19:52448551T>G	ENST00000293471.6	+	6	2094	c.1415T>G	c.(1414-1416)aTt>aGt	p.I472S	ZNF613_ENST00000391794.4_Missense_Mutation_p.I436S|ZNF613_ENST00000601794.1_3'UTR	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		TCAGGTCTCATTAACCACCAG	0.423000													40	53					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													7	82					0	0	1	0	0
TMEM208	29100	broad.mit.edu	37	16	67262480	67262480	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr16:67262480A>G	ENST00000563953.1	+	4	461	c.35A>G	c.(34-36)gAt>gGt	p.D12G	TMEM208_ENST00000565201.1_Missense_Mutation_p.D82G|TMEM208_ENST00000563426.1_3'UTR|TMEM208_ENST00000304800.9_Missense_Mutation_p.D82G			Q9BTX3	TM208_HUMAN	transmembrane protein 208	82						integral to membrane				breast(1)|kidney(2)|lung(1)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TTCTCTGAGGATGGGGCCCTG	0.622000													15	14					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227333333	227333333	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr1:227333333T>C	ENST00000366769.3	-	8	2291	c.1000A>G	c.(1000-1002)Ata>Gta	p.I334V	CDC42BPA_ENST00000366764.2_Missense_Mutation_p.I334V|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.I334V|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.I334V|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.I334V|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.I334V|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.I334V	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	334	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				AAGTCTTCTATTCCATTTTGA	0.393000													58	89					0	0	1	0	0
AC022596.6	0	broad.mit.edu	37	17	16723346	16723346	+	RNA	SNP	C	C	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr17:16723346C>T	ENST00000417510.1	-	0	773																											GTCCAGCACCCCAGCACCTGG	0.557000													33	208					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12712508	12712508	+	Missense_Mutation	SNP	G	G	A	rs148666498		TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chrX:12712508G>A	ENST00000380682.1	+	9	1374	c.868G>A	c.(868-870)Gtc>Atc	p.V290I		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	290	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AATTAGCTTCGTCCCAAAAGA	0.413000													30	83					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091638	74091638	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr18:74091638G>A	ENST00000443185.2	-	4	2749	c.2432C>T	c.(2431-2433)tCc>tTc	p.S811F	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TCCGCTCCGGGAAAGGAAAAC	0.612000													29	30					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37366507	37366507	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr3:37366507A>T	ENST00000361924.2	+	14	3504	c.3130A>T	c.(3130-3132)Ata>Tta	p.I1044L	GOLGA4_ENST00000356847.4_Missense_Mutation_p.I1066L|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1044	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CAATGATGTCATATCAATCTG	0.378000													21	15					0	0	1	0	0
TUBB4A	10382	broad.mit.edu	37	19	6495551	6495551	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr19:6495551C>T	ENST00000264071.2	-	4	1330	c.959G>A	c.(958-960)cGc>cAc	p.R320H	TUBB4A_ENST00000540257.1_Missense_Mutation_p.R320H			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	320					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity										CATGGACATGCGGCCCCGGAA	0.637000													5	192					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77331217	77331217	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr16:77331217T>G	ENST00000282849.5	-	18	3188	c.2770A>C	c.(2770-2772)Aaa>Caa	p.K924Q		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	924					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTGCAGATTTTGGGCTCAGTT	0.398000													4	97					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21555612	21555612	+	Silent	SNP	G	G	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr13:21555612G>T	ENST00000382592.4	-	6	3063	c.2658C>A	c.(2656-2658)ctC>ctA	p.L886L	LATS2_ENST00000542899.1_Silent_p.L886L	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	886	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TACCTTTGCGGAGGAGCACCT	0.607000													13	28					7.07596e-05	7.68247e-05	1	1	0
RP11-544M22.1	0	broad.mit.edu	37	1	160905974	160905975	+	RNA	INS	-	-	T			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr1:160905974_160905975insT	ENST00000356006.3	+	0	629																											tcttcttcttcttttttttttt	0.391													3	5	---	---	---	---					
RNF20	56254	broad.mit.edu	37	9	104307131	104307133	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr9:104307131_104307133delTCT	ENST00000389120.3	+	6	801_803	c.711_713delTCT	c.(709-714)gat>ga	p.DL237del		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	237					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AATTGACAGATCTTCTTCAGGAA	0.458													54	93	---	---	---	---					
BCL2L2	599	broad.mit.edu	37	14	23778132	23778132	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr14:23778132delG	ENST00000250405.5	+	4	769	c.540delG	c.(538-540)ctfs	p.L180fs	BCL2L2-PABPN1_ENST00000553781.1_Intron|BCL2L2-PABPN1_ENST00000557008.1_Intron	NM_001199839.1|NM_004050.4	NP_001186768.1|NP_004041.1			BCL2-like 2											central_nervous_system(1)|lung(4)|prostate(1)	6	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00654)		CCGTGGCACTGGGGGCCCTGG	0.652													16	74	---	---	---	---					
SCARNA15	0	broad.mit.edu	37	20	41933319	41933319	+	RNA	DEL	A	A	-	rs79619980		TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr20:41933319delA	ENST00000516384.1	+	0	125																											TATCaatagcaaaaaaaaaaa	0.318													2	4	---	---	---	---					
BCAS1	8537	broad.mit.edu	37	20	52558052	52558052	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QR-A6GW-01A-11D-A35D-08	TCGA-QR-A6GW-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cbc6621-a98f-4724-9162-14b25e317fe5	57bdb1f0-0ec2-4ae9-94c0-1e2e314e6687	g.chr20:52558052delT	ENST00000371440.3	-	12	2127	c.1790delA	c.(1789-1791)agfs	p.K597fs	AC005220.3_ENST00000450473.1_RNA			O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	0						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GAAGACACACTTCCCTGTGTA	0.403													2	4	---	---	---	---					
