Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AHNAK	79026	broad.mit.edu	37	11	62295869	62295869	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr11:62295869A>T	ENST00000378024.4	-	5	6294	c.6020T>A	c.(6019-6021)aTg>aAg	p.M2007K	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2007					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGACACATCCATATCCCCTTT	0.483000													5	353					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101473220	101473220	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr10:101473220T>C	ENST00000370483.5	-	9	1168	c.1118A>G	c.(1117-1119)aAc>aGc	p.N373S	CUTC_ENST00000493385.1_Intron	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	0					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		aaaagtaaagttgaataagac	0.358000													10	37					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141092044	141092044	+	Silent	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr2:141092044T>C	ENST00000389484.3	-	79	13172	c.12201A>G	c.(12199-12201)caA>caG	p.Q4067Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4067					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTAAGTTCTTTTGTACTAAAA	0.398000										TSP Lung(27;0.18)			22	33					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14031583	14031583	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr19:14031583C>A	ENST00000318003.7	+	14	1730	c.1489C>A	c.(1489-1491)Cta>Ata	p.L497I	CC2D1A_ENST00000589606.1_Missense_Mutation_p.L497I	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	497					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GCTGGCCTTCCTAGAGGGCCG	0.647000													12	11					6.40141e-05	6.61479e-05	1	1	0
ZAN	7455	broad.mit.edu	37	7	100363053	100363053	+	RNA	SNP	G	G	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr7:100363053G>A	ENST00000542585.1	+	0	4494				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGATTCTCCGGCATGTTCTGC	0.617000													3	31					0	0	1	0	0
PCDHA10	0	broad.mit.edu	37	5	140236490	140236490	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr5:140236490C>T	ENST00000307360.5	+	1	857	c.857C>T	c.(856-858)cCc>cTc	p.P286L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.P286L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGTCCCACCCACGATAAGA	0.358000													25	4					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17883154	17883154	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr2:17883154G>A	ENST00000448223.2	-	20	2434	c.2165C>T	c.(2164-2166)tCt>tTt	p.S722F	SMC6_ENST00000381272.4_Missense_Mutation_p.S748F|SMC6_ENST00000351948.4_Missense_Mutation_p.S722F|SMC6_ENST00000402989.1_Missense_Mutation_p.S722F	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	722					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCGAATTTCAGAAATATTTTT	0.249000													12	26					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55401054	55401054	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr19:55401054G>A	ENST00000355524.3	+	5	699	c.689G>A	c.(688-690)cGc>cAc	p.R230H	FCAR_ENST00000391726.3_Missense_Mutation_p.R122H|FCAR_ENST00000359272.4_Missense_Mutation_p.R218H|FCAR_ENST00000345937.4_Missense_Mutation_p.R134H|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000391723.3_Silent_p.P193P|FCAR_ENST00000391724.3_Missense_Mutation_p.R196H|FCAR_ENST00000353758.4_Missense_Mutation_p.R121H|FCAR_ENST00000391725.3_Missense_Mutation_p.R208H	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	230					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity	p.R230H(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		AACTTGATCCGCATGGCCGTG	0.532000													5	355					0	0	1	0	0
RFC5	5985	broad.mit.edu	37	12	118463630	118463630	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr12:118463630G>T	ENST00000392542.2	+	8	1130	c.597G>T	c.(595-597)ttG>ttT	p.L199F	RFC5_ENST00000229043.3_Missense_Mutation_p.L135F|RFC5_ENST00000454402.2_Missense_Mutation_p.L220F	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	220					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGAACATTTTGCAGGTATGGT	0.418000													4	60					2.56e-06	2.73655e-06	1	1	0
XDH	7498	broad.mit.edu	37	2	31628832	31628832	+	Splice_Site	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr2:31628832T>C	ENST00000379416.3	-	2	91		c.e2-2			NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase						purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTCCACCACCTATTAAAATAA	0.383000													17	40					0	0	1	0	0
PCED1A	64773	broad.mit.edu	37	20	2819277	2819277	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr20:2819277C>T	ENST00000360652.2	-	5	1061	c.559G>A	c.(559-561)Ggg>Agg	p.G187R	PCED1A_ENST00000356872.3_Missense_Mutation_p.G136R	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		ATACGTTCCCCGAGGGGCATC	0.577000													27	45					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688235	109688235	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr9:109688235A>G	ENST00000277225.5	+	3	2331	c.2042A>G	c.(2041-2043)aAt>aGt	p.N681S	ZNF462_ENST00000457913.1_Missense_Mutation_p.N681S			Q96JM2	ZN462_HUMAN	zinc finger protein 462	681					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AAGCTCGCCAATGACTTTCCT	0.448000													18	145					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7283232	7283232	+	Silent	SNP	C	C	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr7:7283232C>T	ENST00000436587.2	+	4	1189	c.966C>T	c.(964-966)ctC>ctT	p.L322L	C1GALT1_ENST00000223122.2_Silent_p.L322L	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	322					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TAGAATACCTCGTTTATCATC	0.353000													4	152					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740077	39740077	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr17:39740077G>A	ENST00000167586.6	-	4	948	c.862C>T	c.(862-864)Cgt>Tgt	p.R288C		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	288	Coil 2.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				TACTGGTCACGCATCTCGTTC	0.557000													4	123					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821618	72821618	+	Silent	SNP	A	A	G	rs112443847		TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr16:72821618A>G	ENST00000268489.5	-	10	11229	c.10557T>C	c.(10555-10557)ggT>ggC	p.G3519G	ZFHX3_ENST00000397992.5_Silent_p.G2605G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3519	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G3519G(3)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccaccgccgccgc	0.716000													3	27					0	0	1	0	0
PLP1	5354	broad.mit.edu	37	X	103040511	103040511	+	Splice_Site	SNP	G	G	A			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chrX:103040511G>A	ENST00000418604.1	+	3	285	c.4_splice	c.e3-1	p.G2_splice	PLP1_ENST00000361621.2_Splice_Site_p.G2_splice|PLP1_ENST00000303958.2_Splice_Site_p.G2_splice	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	2					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						TCTTCCCCAGGCTTGTTAGAG	0.562000													65	19					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230825896	230825896	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr1:230825896A>G	ENST00000534989.1	+	16	2089	c.1754A>G	c.(1753-1755)cAt>cGt	p.H585R	COG2_ENST00000366668.3_Missense_Mutation_p.H643R|COG2_ENST00000366669.4_Missense_Mutation_p.H644R|COG2_ENST00000546013.1_Missense_Mutation_p.H333R|COG2_ENST00000535166.1_Missense_Mutation_p.H528R			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	644					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GAAAGCACTCATAAGTAAGTA	0.473000													34	47					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5720980	5720980	+	Silent	SNP	C	C	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr4:5720980C>T	ENST00000382674.2	+	2	364	c.180C>T	c.(178-180)gaC>gaT	p.D60D	EVC_ENST00000509451.1_Silent_p.D60D|EVC_ENST00000264956.6_Silent_p.D60D			P57679	EVC_HUMAN	Ellis van Creveld syndrome	60					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TTTAGAAAGACGACACTCAAA	0.522000													44	70					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95414857	95414857	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr9:95414857G>C	ENST00000287996.3	-	4	566	c.290C>G	c.(289-291)cCa>cGa	p.P97R		NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	97					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						ACCCTTACCTGGTCTTTCAGA	0.313000													40	61					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183832016	183832016	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr2:183832016A>G	ENST00000360982.2	-	17	2332	c.1574T>C	c.(1573-1575)aTa>aCa	p.I525T	NCKAP1_ENST00000361354.3_Missense_Mutation_p.I519T	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	519					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			ATGAAAAATTATTGTATTCAT	0.333000													41	53					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907458	12907458	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr1:12907458T>C	ENST00000317869.6	-	2	910	c.685A>G	c.(685-687)Atg>Gtg	p.M229V		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCTTTCTTCATGGAGCTACTG	0.458000													5	68					0	0	1	0	0
IGHV1OR15-9	0	broad.mit.edu	37	15	20170029	20170029	+	RNA	SNP	C	C	T	rs144252881	by1000genomes	TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr15:20170029C>T	ENST00000338912.5	-	0	242																											CCTGGAACTTCTGTGCATAGC	0.547000													4	162					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30793592	30793592	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr16:30793592T>C	ENST00000262525.4	-	3	2264	c.2057A>G	c.(2056-2058)aAc>aGc	p.N686S		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	686					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			GGGCTTTTCGTTGCCGTGGGT	0.572000													3	14					0	0	1	0	0
RSU1P2	0	broad.mit.edu	37	10	45602582	45602582	+	RNA	SNP	T	T	C			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr10:45602582T>C	ENST00000423875.1	-	0	854																											ACCCAACCATTTGAGGTCTGA	0.443000													24	6					0	0	1	0	0
SOX13	9580	broad.mit.edu	37	1	204083473	204083473	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr1:204083473delG	ENST00000367204.1	+	3	353	c.244delG	c.(244-246)ggfs	p.G82fs	SOX13_ENST00000367203.4_3'UTR	NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	82					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			AGAGGGTAATGGGTCCCCAGA	0.552													2	4	---	---	---	---					
ANO10	55129	broad.mit.edu	37	3	43647213	43647213	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr3:43647213delT	ENST00000292246.3	-	2	302	c.132delA	c.(130-132)aafs	p.K44fs	ANO10_ENST00000414522.2_Frame_Shift_Del_p.K44fs|ANO10_ENST00000350459.4_Frame_Shift_Del_p.K44fs|ANO10_ENST00000396091.3_Frame_Shift_Del_p.K44fs|ANO10_ENST00000451430.2_Frame_Shift_Del_p.K44fs	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	44					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						CACCTCCATCTTTTTTTTTAG	0.408													7	89	---	---	---	---					
P4HTM	54681	broad.mit.edu	37	3	49027893	49027894	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr3:49027893_49027894insCA	ENST00000343546.4	+	1	572_573	c.204_205insCA	c.(202-207)gtacctfs	p.P69fs	P4HTM_ENST00000383729.4_Frame_Shift_Ins_p.P69fs	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	69						endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	TGGTGTTCGTGCACCTGTACCT	0.693													7	34	---	---	---	---					
ZNF367	195828	broad.mit.edu	37	9	99180259	99180261	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr9:99180259_99180261delGGC	ENST00000375256.4	-	1	350_352	c.54_56delGCC	c.(52-57)ccc>cc	p.PP18del		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	18	Pro-rich.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				GAAGATGACGggcggcggcggcg	0.749													2	4	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													4	9	---	---	---	---					
ADAMTS7	11173	broad.mit.edu	37	15	79058183	79058184	+	Frame_Shift_Ins	INS	-	-	TGGGTCC			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr15:79058183_79058184insTGGGTCC	ENST00000388820.4	-	19	4279_4280	c.4069_4070insGGACCCA	c.(4069-4071)gggfs	p.-1357fs		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						AGGCTGACCCTTGGGTCCTGGG	0.653													3	4	---	---	---	---					
GRIN3B	116444	broad.mit.edu	37	19	1009186	1009188	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr19:1009186_1009188delAGC	ENST00000234389.3	+	9	2736_2738	c.2717_2719delAGC	c.(2716-2721)gag>g	p.EQ906del		NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	906					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCCGAGGTGGagcagcagcagca	0.744													2	4	---	---	---	---					
MAN2B1	4125	broad.mit.edu	37	19	12758270	12758271	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QR-A6H1-01A-11D-A35D-08	TCGA-QR-A6H1-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	48af468f-3639-463b-ac97-9ce3032a965e	a3f547ad-3e04-4448-93c7-458be8e87b22	g.chr19:12758270_12758271insT	ENST00000456935.2	-	22	2846_2847	c.2806_2807insA	c.(2806-2808)cttfs	p.L936fs	CTD-2192J16.22_ENST00000597692.1_Frame_Shift_Ins_p.S122fs|MAN2B1_ENST00000221363.4_Frame_Shift_Ins_p.L935fs	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	936					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CAAGTTCAAGGTAACGGGGGCG	0.579													52	80	---	---	---	---					
