Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM188A	80013	broad.mit.edu	37	10	15883458	15883458	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr10:15883458G>A	ENST00000277632.3	-	4	596	c.376C>T	c.(376-378)Cct>Tct	p.P126S	FAM188A_ENST00000477891.1_5'UTR	NM_024948.2	NP_079224.1	Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	126					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						GACTCTGCAGGACTCCCAGAA	0.348000													5	36					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50904710	50904710	+	Silent	SNP	G	G	C			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr14:50904710G>C	ENST00000013125.4	-	24	2043	c.1725C>G	c.(1723-1725)ctC>ctG	p.L575L		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	575	CNH.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					TGTGAGAGTAGAGCTGAAAGG	0.348000													3	39					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88767438	88767438	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr4:88767438C>A	ENST00000497649.2	+	6	1724	c.1346C>A	c.(1345-1347)cCc>cAc	p.P449H	MEPE_ENST00000424957.3_Missense_Mutation_p.P473H|MEPE_ENST00000540395.1_Missense_Mutation_p.P360H|MEPE_ENST00000560249.1_Missense_Mutation_p.P360H|MEPE_ENST00000361056.3_Missense_Mutation_p.P473H|MEPE_ENST00000395102.4_Missense_Mutation_p.P504H|MEPE_ENST00000508016.1_3'UTR			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	473					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		CATTATGTACCCCACAGACAA	0.413000													6	45					3.59834e-05	3.95817e-05	1	1	0
AGBL1	123624	broad.mit.edu	37	15	86810268	86810268	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr15:86810268T>G	ENST00000441037.2	+	12	1756	c.1661T>G	c.(1660-1662)tTt>tGt	p.F554C	AGBL1_ENST00000421325.2_Missense_Mutation_p.F554C|AGBL1_ENST00000389298.3_Missense_Mutation_p.F285C	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	554					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TTCTCCAAATTTGAGTCAGGA	0.408000													4	1					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													3	44					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113888241	113888241	+	Silent	SNP	T	T	C			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr13:113888241T>C	ENST00000451881.1	+	7	655	c.406T>C	c.(406-408)Ttg>Ctg	p.L136L	CUL4A_ENST00000326335.4_Silent_p.L136L|CUL4A_ENST00000375441.3_Silent_p.L136L|CUL4A_ENST00000375440.4_Silent_p.L236L	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	236					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			ACTGAAATTTTTGGAAGAGAC	0.403000													5	46					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815687	106815687	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr8:106815687T>C	ENST00000407775.2	+	8	3627	c.3377T>C	c.(3376-3378)aTc>aCc	p.I1126T	RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.I994T|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000378472.4_Missense_Mutation_p.I857T|ZFPM2_ENST00000517361.1_Missense_Mutation_p.I994T|RP11-152P17.2_ENST00000509144.2_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1126					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTATGTGATATCCAGTTCAAC	0.418000													3	19					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113145101	113145101	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr3:113145101C>A	ENST00000393845.2	-	4	343	c.277G>T	c.(277-279)Gct>Tct	p.A93S	WDR52-AS1_ENST00000498480.1_RNA|WDR52-AS1_ENST00000473329.1_RNA|WDR52_ENST00000295868.2_Missense_Mutation_p.A93S	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	93										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						TCTTCCACAGCTGGAGCAGGG	0.398000													4	84					0.00909568	0.00952881	1	1	0
ZNF519	162655	broad.mit.edu	37	18	14106297	14106297	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr18:14106297A>G	ENST00000590202.1	-	3	394	c.242T>C	c.(241-243)tTa>tCa	p.L81S	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						GTTTTTCCATAAGCATATATT	0.353000													17	19					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr20:29625885A>T	ENST00000278882.3	+	5	509	c.129A>T	c.(127-129)aaA>aaT	p.K43N	FRG1B_ENST00000358464.4_Missense_Mutation_p.K43N|FRG1B_ENST00000439954.2_Missense_Mutation_p.K48N														p.K43N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCGCCCTGAAATCTGGCTATG	0.353000													4	67					0	0	1	0	0
MORN4	118812	broad.mit.edu	37	10	99376082	99376082	+	Missense_Mutation	SNP	A	A	C			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr10:99376082A>C	ENST00000335628.3	-	4	552	c.553T>G	c.(553-555)Tgt>Ggt	p.C185G	MORN4_ENST00000307450.6_Missense_Mutation_p.C127G|MORN4_ENST00000478953.1_3'UTR|PI4K2A_ENST00000555577.1_Intron|PI4K2A_ENST00000370649.3_Intron			Q8NDC4	MORN4_HUMAN	MORN repeat containing 4	127										large_intestine(1)|lung(1)|stomach(2)	4						ATGGCAGAACACTTCTCACGT	0.542000													9	17					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													4	79					0	0	1	0	0
INTS4L2	0	broad.mit.edu	37	7	65150816	65150816	+	RNA	DEL	A	A	-			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr7:65150816delA	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCC	0.463													9	23	---	---	---	---					
MED25	81857	broad.mit.edu	37	19	50338834	50338834	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chr19:50338834delA	ENST00000312865.6	+	15	1771	c.1718delA	c.(1717-1719)ggfs	p.E573fs	MED25_ENST00000538643.1_Frame_Shift_Del_p.E360fs	NM_030973.3	NP_112235.2	Q71SY5	MED25_HUMAN	mediator complex subunit 25	573	Interaction with RARA.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)|urinary_tract(1)	17		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		CCCATTCTGGAGGACCAAGCC	0.667													2	4	---	---	---	---					
MBTPS2	51360	broad.mit.edu	37	X	21857869	21857871	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chrX:21857869_21857871delTGG	ENST00000365779.2	+	1	98_100	c.17_19delTGG	c.(16-21)ctg>c	p.LV6del	MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000379484.5_In_Frame_Del_p.LV6del			O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase, site 2	6					cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						CCGGTGTCGCTGGTGGTGGTGGT	0.685													3	5	---	---	---	---					
PCYT1B	9468	broad.mit.edu	37	X	24637194	24637195	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-QR-A6H2-01A-11D-A35D-08	TCGA-QR-A6H2-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9cc04779-bc1d-4dc1-8d3b-e2b2eca28e1b	bb232599-25b5-450c-ad06-07c2393d0e15	g.chrX:24637194_24637195delGT	ENST00000379145.1	-	2	114_115	c.70_71delAC	c.(70-72)tfs	p.T24fs	PCYT1B_ENST00000379144.2_Frame_Shift_Del_p.T42fs|PCYT1B_ENST00000356768.4_Frame_Shift_Del_p.T42fs	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	42						endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	GGCAGGTGCAGTCAGGGTCTAG	0.480													10	2	---	---	---	---					
