Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RASL11B	65997	broad.mit.edu	37	4	53731672	53731672	+	Silent	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr4:53731672C>T	ENST00000248706.3	+	4	665	c.447C>T	c.(445-447)gtC>gtT	p.V149V	RASL11B_ENST00000505041.1_3'UTR	NM_023940.2	NP_076429.1	Q9BPW5	RSLBB_HUMAN	RAS-like, family 11, member B	149	Small GTPase-like.				small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			autonomic_ganglia(1)|central_nervous_system(1)|lung(5)|ovary(1)|stomach(1)	9			LUSC - Lung squamous cell carcinoma(32;0.0302)			CTGTGGTGGTCGTGGCCAACA	0.547000													5	138					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192788	152192788	+	Silent	SNP	G	G	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr1:152192788G>A	ENST00000368801.2	-	3	1392	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	439					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGTTGGCCGGAGCTGGGAG	0.617000													4	131					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869931	97869931	+	Missense_Mutation	SNP	A	A	T	rs76309140		TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr2:97869931A>T	ENST00000420699.2	+	50	3236	c.2992A>T	c.(2992-2994)Aca>Tca	p.T998S	ANKRD36_ENST00000461153.2_Missense_Mutation_p.T998S	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	998								p.T998S(13)		endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CATTCAGGCTACAAGTGATGA	0.289000													4	22					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													4	135					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41038870	41038870	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr5:41038870G>T	ENST00000399564.4	-	21	2632	c.2182C>A	c.(2182-2184)Caa>Aaa	p.Q728K	MROH2B_ENST00000506092.2_Missense_Mutation_p.Q283K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GACAGGACTTGGGATATGATA	0.517000													3	33					0.115264	0.115264	1	1	0
ZSCAN31	64288	broad.mit.edu	37	6	28294493	28294493	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr6:28294493C>T	ENST00000414429.1	-	8	1574	c.671G>A	c.(670-672)aGc>aAc	p.S224N	ZSCAN31_ENST00000396838.2_Missense_Mutation_p.S224N|ZSCAN31_ENST00000481934.1_5'UTR|ZSCAN31_ENST00000446474.1_Missense_Mutation_p.S65N|ZSCAN31_ENST00000344279.6_Missense_Mutation_p.S224N|ZSCAN31_ENST00000439158.1_Missense_Mutation_p.S224N					zinc finger and SCAN domain containing 31																		TTCTGCCTTGCTGTCTCGTTT	0.423000													6	124					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3131089	3131089	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr12:3131089G>A	ENST00000359864.2	+	10	993	c.803G>A	c.(802-804)cGc>cAc	p.R268H	TEAD4_ENST00000397122.2_Missense_Mutation_p.R139H|TEAD4_ENST00000358409.2_Missense_Mutation_p.R225H	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	268					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GTGGACATCCGCCAAATCTAT	0.527000													5	151					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814297	123814297	+	Silent	SNP	G	G	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr11:123814297G>A	ENST00000321252.2	-	1	283	c.249C>T	c.(247-249)gtC>gtT	p.V83V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V83V(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGAGGATGACGACAAGCATCT	0.507000													4	75					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155154083	155154083	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr6:155154083C>T	ENST00000367178.3	+	20	3946	c.3370C>T	c.(3370-3372)Cgg>Tgg	p.R1124W	SCAF8_ENST00000417268.1_Missense_Mutation_p.R1124W|SCAF8_ENST00000367186.4_Missense_Mutation_p.R1190W|TIAM2_ENST00000461783.3_5'UTR	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1124	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						AGGTAGATTTCGGTCTGGAAA	0.478000													23	39					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102303120	102303120	+	RNA	SNP	C	C	G			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr15:102303120C>G	ENST00000561463.1	+	0	11166																											CTTCTCAGAGCTGCTGTCCAA	0.592000													5	36					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66607419	66607419	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr15:66607419G>A	ENST00000319194.5	+	7	872	c.611G>A	c.(610-612)cGc>cAc	p.R204H	DIS3L_ENST00000441424.2_Missense_Mutation_p.R153H|RP11-352G18.2_ENST00000565993.1_RNA|DIS3L_ENST00000319212.4_Missense_Mutation_p.R287H	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	287					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GCTCGAAACCGCTCAATTCAT	0.478000													4	100					0	0	1	0	0
COL21A1	0	broad.mit.edu	37	6	56044743	56044743	+	Silent	SNP	G	G	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr6:56044743G>A	ENST00000244728.5	-	3	670	c.273C>T	c.(271-273)ctC>ctT	p.L91L	COL21A1_ENST00000370819.1_Silent_p.L91L|COL21A1_ENST00000535941.1_Silent_p.L91L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	91	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CATAGCTTCCGAGAGGAATCT	0.453000													9	22					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71142222	71142222	+	Silent	SNP	C	C	A			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr7:71142222C>A	ENST00000333538.5	+	9	2065	c.1431C>A	c.(1429-1431)gtC>gtA	p.V477V	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	477	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CAAAAGACGTCTGCTTGGACC	0.542000													5	262					2.0095e-06	2.08127e-06	1	1	0
FKBP8	23770	broad.mit.edu	37	19	18648510	18648510	+	Silent	SNP	C	C	T	rs146804732	byFrequency	TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr19:18648510C>T	ENST00000597960.2	-	6	966	c.846G>A	c.(844-846)tcG>tcA	p.S282S	FKBP8_ENST00000222308.3_Silent_p.S282S|FKBP8_ENST00000544835.2_Silent_p.S122S|FKBP8_ENST00000453489.2_Silent_p.S310S|FKBP8_ENST00000596558.1_Silent_p.S281S			Q14318	FKBP8_HUMAN	FK506 binding protein 8, 38kDa	281					apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	15						GCTTCAGCTGCGAGGCCGCCA	0.617000													22	62					0	0	1	0	0
IGHG3	0	broad.mit.edu	37	14	106237582	106237582	+	RNA	SNP	C	C	T	rs2983776		TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr14:106237582C>T	ENST00000390551.2	-	0	160																											GTAGGACAGCCGGGAAGGTGT	0.637000													4	64					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1101_splice	c.e13-1	p.L368_splice	POLR3B_ENST00000539066.1_Splice_Site_p.L310_splice|POLR3B_ENST00000549195.1_3'UTR	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													6	14					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466101	220466101	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr2:220466101C>T	ENST00000456909.1	+	3	296	c.206C>T	c.(205-207)tCc>tTc	p.S69F	STK11IP_ENST00000295641.10_Missense_Mutation_p.S80F|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	80					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCCGACTCCCCTGTTATT	0.567000													5	37					0	0	1	0	0
SHC1	6464	broad.mit.edu	37	1	154940727	154940727	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr1:154940727C>T	ENST00000448116.2	-	5	977	c.757G>A	c.(757-759)Gcc>Acc	p.A253T	SHC1_ENST00000368453.4_Missense_Mutation_p.A143T|SHC1_ENST00000368445.5_Missense_Mutation_p.A253T|SHC1_ENST00000368449.4_Missense_Mutation_p.A24T|SHC1_ENST00000368450.1_Missense_Mutation_p.A143T|SHC1_ENST00000606391.1_Missense_Mutation_p.A54T	NM_001130040.1	NP_001123512.1	P29353	SHC1_HUMAN	SHC (Src homology 2 domain containing) transforming protein 1	253	PID.				activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	20	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGGTGGTTGGCGATGATCTGA	0.567000													5	279					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	57					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21970988	21970988	+	Missense_Mutation	SNP	G	G	A	rs34170727		TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr9:21970988G>A	ENST00000304494.5	-	2	640	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C	CDKN2A_ENST00000479692.2_Missense_Mutation_p.R73C|CDKN2A_ENST00000530628.2_3'UTR|CDKN2A_ENST00000494262.1_Missense_Mutation_p.R73C|CDKN2A_ENST00000579122.1_Missense_Mutation_p.R124C|CDKN2A_ENST00000498628.2_Missense_Mutation_p.R73C|CDKN2A_ENST00000361570.3_3'UTR|CDKN2A_ENST00000497750.1_Missense_Mutation_p.R73C|CDKN2A_ENST00000578845.2_Missense_Mutation_p.R73C|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000498124.1_Missense_Mutation_p.R124C|CDKN2A_ENST00000446177.1_Missense_Mutation_p.R124C|CDKN2A_ENST00000579755.1_3'UTR	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	124			R -> C (in dbSNP:rs34170727).|R -> H (in an esophagus tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(13)|p.R124fs*22(2)|p.0(1)|p.A118fs*10(1)|p.L121fs*21(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCGACATCGCGATGGCCCAGC	0.711000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			21	21					0	0	1	0	0
GOLGA1	2800	broad.mit.edu	37	9	127674230	127674230	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr9:127674230G>C	ENST00000373555.4	-	11	1252	c.919C>G	c.(919-921)Cta>Gta	p.L307V		NM_002077.3	NP_002068.1	Q92805	GOGA1_HUMAN	golgin A1	307						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						TTCTGTTCTAGTCTCTTCTCC	0.453000													7	66					0	0	1	0	0
RPL32P3	0	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													4	98					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369997	20369997	+	RNA	SNP	C	C	T			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr19:20369997C>T	ENST00000593655.1	-	0	199																											ACGGTTGAAACGAGAACTTAA	0.413000													7	88					0	0	1	0	0
NUMA1	0	broad.mit.edu	37	11	71715362	71715362	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr11:71715362delG	ENST00000393695.3	-	25	6363	c.6032delC	c.(6031-6033)cafs	p.P2011fs	NUMA1_ENST00000351960.6_Frame_Shift_Del_p.P875fs|NUMA1_ENST00000358965.6_Frame_Shift_Del_p.P1997fs	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	2011					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CATGGGGCGTGGGAAACAGCT	0.542			T	RARA	APL								21	49	---	---	---	---					
PREX1	57580	broad.mit.edu	37	20	47444201	47444201	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QR-A6H6-01A-11D-A35D-08	TCGA-QR-A6H6-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac18eca3-999a-48c2-9f96-76b69e4b8395	ef2fc228-103c-4c7e-b676-179029a08831	g.chr20:47444201delC	ENST00000396220.1	-	1	219	c.197delG	c.(196-198)gcfs	p.G66fs	PREX1_ENST00000371941.3_Frame_Shift_Del_p.G66fs			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	66	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCGCAAGGTGCCCACGTAGTC	0.716													2	4	---	---	---	---					
