Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VCP	7415	broad.mit.edu	37	9	35060506	35060506	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr9:35060506G>A	ENST00000358901.6	-	13	2394	c.1499C>T	c.(1498-1500)cCa>cTa	p.P500L		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	500					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GAATTTGTCTGGGTGCTCCAC	0.453000													15	37					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	33					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49160648	49160648	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:49160648T>A	ENST00000418109.1	-	27	4305	c.4141A>T	c.(4141-4143)Agc>Tgc	p.S1381C	LAMB2_ENST00000305544.4_Missense_Mutation_p.S1381C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1381	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATGTGTTTGCTGTTGAAGTCC	0.557000													37	25					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169993051	169993051	+	Silent	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:169993051G>A	ENST00000295797.4	+	8	986	c.681G>A	c.(679-681)ttG>ttA	p.L227L		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	227	Regulatory domain.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			ATGAGAGTTTGGATCAAGTTG	0.289000													7	162					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49160646	49160646	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:49160646G>T	ENST00000418109.1	-	27	4307	c.4143C>A	c.(4141-4143)agC>agA	p.S1381R	LAMB2_ENST00000305544.4_Missense_Mutation_p.S1381R	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1381	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCATGTGTTTGCTGTTGAAGT	0.562000													38	25					1.38162e-09	1.60567e-09	1	1	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334038	39334038	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr17:39334038G>A	ENST00000377726.2	-	1	422	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	127	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CAGGTTGGGCGGCAGCAGGTG	0.582000													40	89					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940079	22940079	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr19:22940079C>A	ENST00000397104.3	-	6	2251	c.2252G>T	c.(2251-2253)tGt>tTt	p.C751F						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGCTTTGCCACATTCTTCACA	0.343000													20	64					1.56452e-12	1.92213e-12	1	1	0
A2M	2	broad.mit.edu	37	12	9256869	9256869	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr12:9256869G>C	ENST00000318602.7	-	11	1539	c.1232C>G	c.(1231-1233)aCc>aGc	p.T411S		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	411					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	AACATTGGTGGTGTTGATAGA	0.403000													3	23					0	0	1	0	0
CST5	1473	broad.mit.edu	37	20	23860252	23860252	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr20:23860252C>A	ENST00000304710.4	-	1	135	c.62G>T	c.(61-63)gGg>gTg	p.G21V		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	21						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						CGAGGCACTCCCGGCCACGGC	0.597000													29	59					4.59853e-10	5.49269e-10	1	1	0
NEDD4	4734	broad.mit.edu	37	15	56142797	56142797	+	Silent	SNP	C	C	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr15:56142797C>T	ENST00000508342.1	-	10	2846	c.2547G>A	c.(2545-2547)cgG>cgA	p.R849R	NEDD4_ENST00000338963.2_Silent_p.R777R|NEDD4_ENST00000506154.1_Silent_p.R833R|NEDD4_ENST00000435532.3_Silent_p.R430R			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	849	Mediates interaction with TNIK (By similarity).|WW 3.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TTGGTGCATGCCGGACTTCCC	0.453000													4	194					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520580	33520580	+	Silent	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr17:33520580G>A	ENST00000297307.5	-	1	832	c.747C>T	c.(745-747)gaC>gaT	p.D249D		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	249						integral to membrane											AACTCAGGAGGTCACTGGGCA	0.642000													4	100					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1551468	1551468	+	Silent	SNP	C	C	G			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr16:1551468C>G	ENST00000262319.6	+	10	1608	c.1329C>G	c.(1327-1329)ccC>ccG	p.P443P		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	443						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				TGGCCTCCCCCCAGCCTGCGG	0.701000													9	5					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													4	17					0	0	1	0	0
RP11-248G5.8	0	broad.mit.edu	37	13	52742043	52742043	+	RNA	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr13:52742043G>A	ENST00000451298.1	-	0	3596				RP11-64P12.8_ENST00000606031.1_RNA																							TCTACAAAACGCGAGTAGCAG	0.448000													5	7					0	0	1	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37948042	37948042	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr1:37948042C>T	ENST00000373087.6	+	5	942	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_025079.2	NP_079355.2	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	276					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGGTTTATGCCCCCTGATGA	0.592000													4	106					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603238	111603238	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:111603238T>C	ENST00000431670.2	+	2	725	c.314T>C	c.(313-315)aTg>aCg	p.M105T	PHLDB2_ENST00000393925.3_Missense_Mutation_p.M105T|PHLDB2_ENST00000393923.3_Missense_Mutation_p.M132T|PHLDB2_ENST00000477695.1_Missense_Mutation_p.M105T|PHLDB2_ENST00000412622.1_Missense_Mutation_p.M105T|PHLDB2_ENST00000481953.1_Missense_Mutation_p.M105T|PHLDB2_ENST00000478922.1_Missense_Mutation_p.M105T	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	105						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						AATATTCCTATGAAACCTCCA	0.463000													142	117					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	100					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31362169	31362169	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr15:31362169C>A	ENST00000559179.1	-	3	411	c.278G>T	c.(277-279)aGc>aTc	p.S93I	TRPM1_ENST00000542188.1_Intron|TRPM1_ENST00000256552.6_Intron|TRPM1_ENST00000397795.2_Intron	NM_001252030.1	NP_001238959.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1378					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CAGTTTGGGGCTGGGAGACTG	0.463000													5	290					0.000602214	0.00064738	1	1	0
MTHFD2P1	0	broad.mit.edu	37	3	95374420	95374420	+	RNA	SNP	A	A	G			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:95374420A>G	ENST00000494840.1	-	0	1441					NR_077228.1																						CTGGAGAAAAAGCATTGCAGA	0.413000													3	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179469737	179469737	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr2:179469737C>T	ENST00000589042.1	-	280	54391	c.54167G>A	c.(54166-54168)cGa>cAa	p.R18056Q	TTN_ENST00000460472.2_Missense_Mutation_p.R8991Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9183Q|TTN_ENST00000359218.5_Missense_Mutation_p.R9116Q|TTN_ENST00000591111.1_Missense_Mutation_p.R16415Q|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R15488Q|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16415	Fibronectin type-III 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGAACATTTCGGAACACTGA	0.438000													79	116					0	0	1	0	0
IL19	29949	broad.mit.edu	37	1	207014409	207014409	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr1:207014409G>A	ENST00000270218.6	+	6	1363	c.424G>A	c.(424-426)Gac>Aac	p.D142N	IL19_ENST00000340758.2_Missense_Mutation_p.D180N	NM_013371.3	NP_037503.2	Q9UHD0	IL19_HUMAN	interleukin 19	142					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			central_nervous_system(2)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7			BRCA - Breast invasive adenocarcinoma(75;0.211)			AGTCATCCATGACAACTATGA	0.512000													10	29					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6454709	6454709	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr19:6454709C>A	ENST00000301454.4	-	5	609	c.503G>T	c.(502-504)tGc>tTc	p.C168F	SLC25A23_ENST00000334510.5_Missense_Mutation_p.C168F	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	168					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						CACTGTCAGGCACTCGCCAAT	0.582000													24	63					3.28513e-13	4.15472e-13	1	1	0
FAM179B	23116	broad.mit.edu	37	14	45523651	45523651	+	Silent	SNP	A	A	G			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr14:45523651A>G	ENST00000361462.2	+	16	4641	c.4458A>G	c.(4456-4458)ccA>ccG	p.P1486P	FAM179B_ENST00000361577.3_Silent_p.P1433P|FAM179B_ENST00000382233.2_3'UTR			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1433							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GGGAGATACCATTAGATACTC	0.323000													17	59					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45894036	45894036	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr17:45894036G>C	ENST00000007414.3	-	10	1012	c.821C>G	c.(820-822)cCc>cGc	p.P274R	OSBPL7_ENST00000392507.3_Missense_Mutation_p.P274R	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	274					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						AGACAGGTTGGGAACAGAGCC	0.652000													4	31					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517139	158517139	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr1:158517139C>T	ENST00000302617.3	-	1	756	c.757G>A	c.(757-759)Gta>Ata	p.V253I		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					AAGAGAATTACGACGGTCAGG	0.507000													8	61					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													3	13					0	0	1	0	0
CGGBP1	8545	broad.mit.edu	37	3	88104673	88104673	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr3:88104673G>T	ENST00000398392.2	-	1	1786	c.454C>A	c.(454-456)Cct>Act	p.P152T	CGGBP1_ENST00000309534.6_Missense_Mutation_p.P152T|CGGBP1_ENST00000462901.1_Missense_Mutation_p.P152T|CGGBP1_ENST00000482016.1_Missense_Mutation_p.P152T			Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding			kidney(1)|large_intestine(2)|lung(2)	5		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		TATCCATCAGGAAGATATGCC	0.448000													7	72					5.18039e-06	5.71171e-06	1	1	0
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr2:29295647_29295649delTCC	ENST00000331664.5	-	1	1478_1480	c.1479_1481delGGA	c.(1477-1482)gaa>ga	p.EE493del		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	493					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CATTTTGTCTTCCTCCTCCTCCT	0.542													7	179	---	---	---	---					
PPIG	9360	broad.mit.edu	37	2	170492941	170492945	+	Frame_Shift_Del	DEL	AAAAG	AAAAG	-			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr2:170492941_170492945delAAAAG	ENST00000260970.3	+	14	1393_1397	c.1173_1177delAAAAG	c.(1171-1179)ataafs	p.IKE391fs	PPIG_ENST00000409714.3_Frame_Shift_Del_p.IKE376fs|PPIG_ENST00000448752.2_Frame_Shift_Del_p.IKE391fs|PPIG_ENST00000482772.1_3'UTR	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	391					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	TGAATGAAATAAAAGAAAATCAGAG	0.288													24	63	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48866909	48866910	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr8:48866909_48866910insT	ENST00000314191.2	-	5	552_553	c.496_497insA	c.(496-498)accfs	p.T166fs	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Frame_Shift_Ins_p.T166fs	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	166					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTATCTGGTATTTTTTTTTTC	0.267								Non-homologous end-joining					2	4	---	---	---	---					
OR9G4	283189	broad.mit.edu	37	11	56511186	56511186	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QR-A708-01A-11D-A35D-08	TCGA-QR-A708-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d09ee8c7-192b-410e-b222-7e1f23d68105	0f893a84-c320-47b8-b18b-a9f7ae480221	g.chr11:56511186delT	ENST00000302957.3	-	1	101	c.102delA	c.(100-102)gcfs	p.A34fs		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						ACTGGGAATCTGCTGAGAAAC	0.433													7	64	---	---	---	---					
