Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ALPK1	80216	broad.mit.edu	37	4	113303581	113303581	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr4:113303581T>A	ENST00000458497.1	+	4	428	c.149T>A	c.(148-150)cTg>cAg	p.L50Q	ALPK1_ENST00000504176.2_Intron|ALPK1_ENST00000177648.9_Missense_Mutation_p.L50Q	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	50							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TTAAGGACCCTGATCCAGGAG	0.478000													3	58					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86308796	86308796	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr2:86308796T>A	ENST00000263857.6	-	8	1229	c.851A>T	c.(850-852)gAt>gTt	p.D284V	POLR1A_ENST00000409681.1_Missense_Mutation_p.D284V			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	284					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						ACCATCATCATCCATTCCCGA	0.403000													14	61					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102293008	102293008	+	RNA	SNP	A	A	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr15:102293008A>G	ENST00000561463.1	+	0	1054																		p.K171E(1)									GCGTGGGAACAAGAAGACACT	0.582000													3	8					0	0	1	0	0
TFAM	7019	broad.mit.edu	37	10	60146034	60146034	+	Silent	SNP	A	A	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr10:60146034A>G	ENST00000487519.1	+	2	682	c.156A>G	c.(154-156)aaA>aaG	p.K52K	TFAM_ENST00000373895.3_Silent_p.K52K|TFAM_ENST00000373899.3_3'UTR	NM_003201.1	NP_003192.1	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial	52					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						GTCCAAAGAAACCTGTAAGTT	0.363000													4	116					0	0	1	0	0
HTR6	3362	broad.mit.edu	37	1	20005098	20005098	+	Silent	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr1:20005098C>T	ENST00000289753.1	+	2	1220	c.753C>T	c.(751-753)gaC>gaT	p.D251D		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	251					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	AGTCTGCTGACAGCAGGCGTC	0.627000													17	51					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33358928	33358928	+	Silent	SNP	T	T	C			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr15:33358928T>C	ENST00000334528.9	-	1	1157	c.1158A>G	c.(1156-1158)ccA>ccG	p.P386P	FMN1_ENST00000561249.1_Intron|FMN1_ENST00000559047.1_Intron|FMN1_ENST00000558197.1_Silent_p.P386P|FMN1_ENST00000559150.1_Intron	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	483	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCTGGGTTTGTGGTACTCCAG	0.592000													47	57					0	0	1	0	0
AWAT1	158833	broad.mit.edu	37	X	69457054	69457054	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chrX:69457054G>C	ENST00000374521.3	+	4	457	c.416G>C	c.(415-417)tGg>tCg	p.W139S	AWAT1_ENST00000480702.1_3'UTR	NM_001013579.2	NP_001013597.1	Q58HT5	AWAT1_HUMAN	acyl-CoA wax alcohol acyltransferase 1	139					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(3)|ovary(4)|skin(1)	15						ACGCTGTCCTGGTTCTTCAAG	0.537000													3	16					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	41					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37455268	37455268	+	Silent	SNP	A	A	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr2:37455268A>G	ENST00000234170.5	-	2	1213	c.1068T>C	c.(1066-1068)gaT>gaC	p.D356D		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	356					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTACTAATGTATCATGACTTA	0.403000													34	90					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62400986	62400986	+	Splice_Site	SNP	C	C	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr11:62400986C>G	ENST00000346178.4	-	7	642	c.626_splice	c.e7-1	p.R209_splice	GANAB_ENST00000540933.1_Splice_Site_p.S90_splice|GANAB_ENST00000356638.3_Splice_Site_p.S187_splice|GANAB_ENST00000534779.1_Splice_Site_p.R95_splice|GANAB_ENST00000534422.1_5'UTR	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	187					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						TTGATCCTTGCCTGGAAGGTA	0.607000													18	35					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84205889	84205889	+	Silent	SNP	A	A	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr9:84205889A>G	ENST00000376499.3	-	16	2724	c.1660T>C	c.(1660-1662)Ttg>Ctg	p.L554L		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	554					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CAAATGGACAAAGTACTGGCT	0.547000													17	117					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73111447	73111447	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr10:73111447G>A	ENST00000373189.5	+	4	564	c.512G>A	c.(511-513)tGc>tAc	p.C171Y	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	171					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						ACCATTGTCTGCATGGTGATC	0.547000													4	81					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66102456	66102456	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr11:66102456C>T	ENST00000311320.4	-	6	940	c.814G>A	c.(814-816)Ggg>Agg	p.G272R	RIN1_ENST00000530056.1_Missense_Mutation_p.G167R|RP11-867G23.12_ENST00000526655.1_RNA|RIN1_ENST00000424433.2_Missense_Mutation_p.G167R	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	272					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						GGGACTGCCCCTGGCAGCACG	0.667000													5	37					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68084697	68084697	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr8:68084697C>T	ENST00000262210.5	+	23	2891	c.2860C>T	c.(2860-2862)Cgg>Tgg	p.R954W	CSPP1_ENST00000412460.1_Missense_Mutation_p.R609W|CSPP1_ENST00000521168.1_3'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	989						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGCTAGACATCGGTTGCAAGC	0.388000													4	62					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114514513	114514513	+	Silent	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr1:114514513C>T	ENST00000369558.1	+	15	3313	c.3081C>T	c.(3079-3081)acC>acT	p.T1027T	HIPK1_ENST00000340480.4_Silent_p.T653T|HIPK1_ENST00000369553.1_Silent_p.T633T|HIPK1_ENST00000369554.2_Silent_p.T982T|HIPK1_ENST00000369555.2_Silent_p.T982T|HIPK1_ENST00000369559.4_Silent_p.T1027T|HIPK1_ENST00000369561.4_Silent_p.T993T|HIPK1_ENST00000426820.2_Silent_p.T1027T|HIPK1_ENST00000406344.1_Silent_p.T633T			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	1027	Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTGTATCACCCCCACAGGGT	0.517000													41	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009599	9009599	+	Silent	SNP	G	G	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr19:9009599G>A	ENST00000397910.4	-	39	39330	c.39127C>T	c.(39127-39129)Ctg>Ttg	p.L13043L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13045	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACCCTGCAGGACCCTCTCT	0.552000													12	149					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89392730	89392730	+	RNA	SNP	G	G	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr11:89392730G>A	ENST00000532352.1	+	0	553							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GCTGGCAGGGGCCAAAGGAGT	0.438000													3	29					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47918530	47918530	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr21:47918530C>T	ENST00000318711.7	+	5	622	c.439C>T	c.(439-441)Cgg>Tgg	p.R147W	DIP2A_ENST00000466639.1_Missense_Mutation_p.R147W|DIP2A_ENST00000427143.2_Missense_Mutation_p.R83W|DIP2A_ENST00000435722.3_Missense_Mutation_p.R147W|DIP2A_ENST00000417564.2_Missense_Mutation_p.R147W|DIP2A_ENST00000457905.3_Missense_Mutation_p.R147W|DIP2A_ENST00000400274.1_Missense_Mutation_p.R147W	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	147					multicellular organismal development	nucleus	catalytic activity|transcription factor binding	p.R147R(2)|p.R83R(1)		cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGGCTCTTTACGGCGACCCGG	0.587000													4	153					0	0	1	0	0
POC1B-GALNT4	0	broad.mit.edu	37	12	89917393	89917393	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr12:89917393C>T	ENST00000548729.1	-	3	1227	c.925G>A	c.(925-927)Gga>Aga	p.G309R	POC1B_ENST00000549504.1_Intron|POC1B_ENST00000541909.1_Intron|POC1B-GALNT4_ENST00000547474.1_3'UTR|GALNT4_ENST00000529983.2_Missense_Mutation_p.G312R|POC1B_ENST00000393179.4_Intron|POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.G140R|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000313546.3_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					GCAAACAGTCCTCCAGCCATG	0.468000													8	125					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7172601	7172601	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr12:7172601G>A	ENST00000406697.1	+	9	1343	c.715G>A	c.(715-717)Gtt>Att	p.V239I	C1S_ENST00000402681.3_Missense_Mutation_p.V72I|C1S_ENST00000360817.5_Missense_Mutation_p.V239I|C1S_ENST00000328916.3_Missense_Mutation_p.V239I			P09871	C1S_HUMAN	complement component 1, s subcomponent	239	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity	p.V239F(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGACAGTTTAGTTGTGCGTGA	0.453000													10	19					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98533274	98533274	+	Missense_Mutation	SNP	G	G	A	rs140553884	by1000genomes	TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr7:98533274G>A	ENST00000359863.4	+	28	4296	c.4087G>A	c.(4087-4089)Gta>Ata	p.V1363I	TRRAP_ENST00000355540.3_Missense_Mutation_p.V1363I|TRRAP_ENST00000446306.3_Missense_Mutation_p.V1362I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1363					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCGTCACTCGTACCTTTACG	0.378000													4	95					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12301949	12301949	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr12:12301949C>G	ENST00000261349.4	-	14	3209	c.3133G>C	c.(3133-3135)Ggg>Cgg	p.G1045R	LRP6_ENST00000543091.1_Missense_Mutation_p.G1045R	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1045	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				ACTGATCTCCCATCTAATCTT	0.463000													74	97					0	0	1	0	0
ANKK1	255239	broad.mit.edu	37	11	113266945	113266945	+	Splice_Site	SNP	G	G	T			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr11:113266945G>T	ENST00000303941.3	+	5	932		c.e5+1			NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1								ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGCTTTCTAGGTGCTTATCCA	0.612000													4	105					0.150653	0.150653	1	1	0
MST1	4485	broad.mit.edu	37	3	49722300	49722300	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr3:49722300C>A	ENST00000449682.2	-	15	2001	c.1640G>T	c.(1639-1641)gGc>gTc	p.G547V	AC099668.5_ENST00000563780.1_RNA	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	533	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TACCTCATAGCCCGTGAGAGG	0.582000													4	49					0.0293803	0.0304296	1	1	0
FBP2	8789	broad.mit.edu	37	9	97355969	97355969	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr9:97355969delG	ENST00000375337.3	-	1	106	c.40delC	c.(40-42)tgfs	p.L14fs		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	14					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				TAGCGGGTCAGGGTGAGCATG	0.552													39	68	---	---	---	---					
MBL1P	0	broad.mit.edu	37	10	81680655	81680656	+	RNA	INS	-	-	A			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr10:81680655_81680656insA	ENST00000480805.1	+	0	722_723					NR_002724.2																						AGCTTTTGGGGAAAAAAAAAAG	0.545													4	7	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													4	7	---	---	---	---					
KRTAP10-4	386672	broad.mit.edu	37	21	45993755	45993769	+	In_Frame_Del	DEL	CTGCTGCGCCCCCAG	CTGCTGCGCCCCCAG	-			TCGA-QR-A70T-01A-11D-A35D-08	TCGA-QR-A70T-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f7c81c93-90ef-4266-9fc0-d5ff6416b139	5683aefc-0242-47e7-a2ca-9fdfa234f0f3	g.chr21:45993755_45993769delCTGCTGCGCCCCCAG	ENST00000400374.3	+	1	150_164	c.120_134delCTGCTGCGCCCCCAG	c.(118-135)ccc>cc	p.PCCAPS40del	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	40	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GCGAGCCCCCCTGCTGCGCCCCCAGCTGCTGCGCC	0.698													9	18	---	---	---	---					
