Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-114H24.7	0	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													4	159					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56281693	56281693	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr17:56281693G>C	ENST00000225371.5	+	12	2167	c.2057G>C	c.(2056-2058)aGg>aCg	p.R686T		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	686					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						ACGGTTTCAAGGGACATCTTC	0.512000													4	78					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	95					0	0	1	0	0
CASP3	836	broad.mit.edu	37	4	185553476	185553476	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr4:185553476C>T	ENST00000308394.4	-	5	515	c.253G>A	c.(253-255)Gtc>Atc	p.V85I	CASP3_ENST00000517513.1_Missense_Mutation_p.V85I|CASP3_ENST00000393585.2_Missense_Mutation_p.V85I|CASP3_ENST00000393588.4_Missense_Mutation_p.V85I|CASP3_ENST00000523916.1_Missense_Mutation_p.V85I	NM_004346.3	NP_004337.2	P42574	CASP3_HUMAN	caspase 3, apoptosis-related cysteine peptidase	85					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	TTATTCCTGACTTCATATTTC	0.338000													4	79					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296440	145296440	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr1:145296440G>A	ENST00000342960.5	+	3	397	c.362G>A	c.(361-363)cGc>cAc	p.R121H	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	121								p.R121H(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGCCTCCCGCTCATTGTAT	0.562000													6	398					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													6	149					0	0	1	0	0
SDHAP3	0	broad.mit.edu	37	5	1593264	1593264	+	RNA	SNP	C	C	T	rs111700178	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr5:1593264C>T	ENST00000436493.2	-	0	361																											AGGGCACATGCCTGACCAAAG	0.557000													4	45					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53945909	53945909	+	RNA	SNP	T	T	C	rs28727441	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr19:53945909T>C	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACCCTGACTCTGCCTGAGGCC	0.562000													4	38					0	0	1	0	0
PCID2	55795	broad.mit.edu	37	13	113854816	113854816	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr13:113854816G>C	ENST00000375457.2	-	2	641	c.45C>G	c.(43-45)atC>atG	p.I15M	PCID2_ENST00000337344.4_Missense_Mutation_p.I17M|PCID2_ENST00000375479.2_Missense_Mutation_p.I17M|PCID2_ENST00000246505.5_Missense_Mutation_p.I17M|PCID2_ENST00000351317.3_Missense_Mutation_p.I17M|PCID2_ENST00000375477.1_Missense_Mutation_p.I17M|PCID2_ENST00000375459.1_Missense_Mutation_p.I15M	NM_001258213.1	NP_001245142.1	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	17					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)	20	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			CTCTGCTGTCGATGGCTTCGT	0.418000													4	65					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154414493	154414493	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr6:154414493G>T	ENST00000229768.5	+	4	1303	c.1253G>T	c.(1252-1254)aGa>aTa	p.R418I	OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000419506.2_Intron|OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000522555.1_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000414028.2_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000434900.2_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000518759.1_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CCTCTTGTCAGATATGACCTC	0.512000													5	191					1.024e-07	1.04676e-07	1	1	0
NLRP6	171389	broad.mit.edu	37	11	281682	281682	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr11:281682C>T	ENST00000534750.1	+	4	2153	c.1948C>T	c.(1948-1950)Cgc>Tgc	p.R650C	NLRP6_ENST00000312165.5_Missense_Mutation_p.R650C	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	650						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCAGCGAGTGCGCTTCTGCCG	0.637000													4	108					0	0	1	0	0
ZNF35	7584	broad.mit.edu	37	3	44692675	44692675	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr3:44692675A>T	ENST00000396056.2	+	2	351	c.116A>T	c.(115-117)cAc>cTc	p.H39L	ZNF35_ENST00000453164.1_Missense_Mutation_p.H39L|ZNF35_ENST00000296092.3_Missense_Mutation_p.H39L|ZNF35_ENST00000399560.2_Missense_Mutation_p.H39L|ZNF35_ENST00000542250.1_5'UTR|RP11-944L7.4_ENST00000457331.1_RNA	NM_003420.3	NP_003411.3	P13682	ZNF35_HUMAN	zinc finger protein 35	39	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		CAACAAGTGCACTCCGAGAAC	0.542000													8	106					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451498	138451498	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr4:138451498C>T	ENST00000344876.4	-	1	2131	c.1745G>A	c.(1744-1746)cGt>cAt	p.R582H	PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.R362H|PCDH18_ENST00000412923.2_Missense_Mutation_p.R582H|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	582	Cadherin 6.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R582H(2)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CGTATTATTACGCAATGCAGG	0.463000													6	237					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	3					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41069761	41069761	+	Splice_Site	SNP	G	G	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chrX:41069761G>A	ENST00000324545.7	+	33	5648		c.e33-1		USP9X_ENST00000378308.2_Splice_Site	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TCATTTCTTAGGCTTTGGGGT	0.328000													5	112					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50192316	50192316	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr22:50192316C>T	ENST00000216267.8	-	4	2161	c.1675G>A	c.(1675-1677)Gcc>Acc	p.A559T	BRD1_ENST00000542442.1_Missense_Mutation_p.A252T|BRD1_ENST00000342989.5_Missense_Mutation_p.A154T|BRD1_ENST00000404760.1_Missense_Mutation_p.A559T|BRD1_ENST00000457780.2_Missense_Mutation_p.A559T|BRD1_ENST00000404034.1_Missense_Mutation_p.A559T	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	559					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCTCCATGGCGACCTGCTCC	0.672000													8	12					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9006392	9006392	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr19:9006392C>T	ENST00000397910.4	-	45	39829	c.39626G>A	c.(39625-39627)aGc>aAc	p.S13209N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13211	SEA 8.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AACACTGGTGCTCTTGAACAA	0.562000													5	145					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38274849	38274849	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr8:38274849G>T	ENST00000447712.2	-	12	2579	c.1638C>A	c.(1636-1638)aaC>aaA	p.N546K	FGFR1_ENST00000356207.5_Missense_Mutation_p.N457K|FGFR1_ENST00000397103.1_Missense_Mutation_p.N457K|FGFR1_ENST00000397091.5_Missense_Mutation_p.N544K|FGFR1_ENST00000532791.1_Missense_Mutation_p.N544K|FGFR1_ENST00000397113.2_Missense_Mutation_p.N544K|FGFR1_ENST00000341462.5_Missense_Mutation_p.N546K|FGFR1_ENST00000425967.3_Missense_Mutation_p.N577K|FGFR1_ENST00000335922.5_Missense_Mutation_p.N536K|FGFR1_ENST00000397108.4_Missense_Mutation_p.N544K|FGFR1_ENST00000326324.6_Missense_Mutation_p.N455K	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	546	Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity	p.N546K(4)	FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CCCCCAGCAGGTTGATGATAT	0.542000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						51	62					2.44813e-32	2.55941e-32	1	1	0
CHD3	1107	broad.mit.edu	37	17	7803968	7803968	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr17:7803968G>A	ENST00000380358.4	+	18	3075	c.3074G>A	c.(3073-3075)cGg>cAg	p.R1025Q	CHD3_ENST00000330494.7_Missense_Mutation_p.R966Q|CHD3_ENST00000358181.4_Missense_Mutation_p.R966Q	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	966					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CACATGCTGCGGAGACTCAAG	0.512000													6	70					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43799001	43799001	+	Splice_Site	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr2:43799001C>T	ENST00000403856.1	-	14	2056	c.1908_splice	c.e14-1	p.V637_splice	THADA_ENST00000330266.7_Splice_Site_p.V347_splice|THADA_ENST00000402360.2_Splice_Site_p.V637_splice|THADA_ENST00000405006.4_Splice_Site_p.V637_splice|THADA_ENST00000404790.1_Splice_Site_p.V637_splice|THADA_ENST00000405975.2_Splice_Site_p.V637_splice|THADA_ENST00000415080.2_Splice_Site_p.V347_splice			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	637							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TCTATCCTTACCTAAAAAACA	0.318000													5	97					0	0	1	0	0
RDH8	50700	broad.mit.edu	37	19	10129527	10129527	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr19:10129527G>A	ENST00000591589.1	+	3	632	c.443G>A	c.(442-444)gGc>gAc	p.G148D	RDH8_ENST00000171214.1_Missense_Mutation_p.G128D			Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	128					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			endometrium(3)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|prostate(1)	21			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GTGCTTCCAGGCATGAAGAGG	0.602000													4	79					0	0	1	0	0
WHAMMP3	0	broad.mit.edu	37	15	23191911	23191911	+	RNA	SNP	C	C	T	rs147199465	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr15:23191911C>T	ENST00000400153.2	-	0	1785					NR_003521.1																						TGATTTTCTTCGCACTGATCC	0.408000													3	49					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261283	1261283	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr16:1261283T>A	ENST00000348261.5	+	22	4587	c.4339T>A	c.(4339-4341)Ttg>Atg	p.L1447M	CACNA1H_ENST00000565831.1_Missense_Mutation_p.L1447M|CACNA1H_ENST00000358590.4_Missense_Mutation_p.L1447M	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1447					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TTTTGGCATTTTGGGTGTGCA	0.637000													8	136					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9068919	9068919	+	Silent	SNP	A	A	G			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr11:9068919A>G	ENST00000457346.2	-	16	2060	c.1986T>C	c.(1984-1986)caT>caC	p.H662H	RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000520467.1_Silent_p.H662H|SCUBE2_ENST00000309263.3_Silent_p.H633H|SCUBE2_ENST00000450649.2_Silent_p.H507H			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	633						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GGTTTTCTGCATGACCCTGGC	0.542000													12	39					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050124	164050124	+	Silent	SNP	T	T	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr4:164050124T>C	ENST00000274054.2	-	8	1603	c.1410A>G	c.(1408-1410)ccA>ccG	p.P470P	NAF1_ENST00000422287.2_Intron|NAF1_ENST00000509434.1_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	470	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				ggggagggggtgggggtaggg	0.522000													11	15					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	60					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155207977	155207977	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr1:155207977T>G	ENST00000428024.2	-	5	950	c.448A>C	c.(448-450)Aag>Cag	p.K150Q	GBA_ENST00000536770.1_Missense_Mutation_p.K124Q|GBA_ENST00000327247.5_Missense_Mutation_p.K237Q|GBA_ENST00000427500.2_Missense_Mutation_p.K188Q|GBA_ENST00000368373.3_Missense_Mutation_p.K237Q	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	237					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GGCTGTCCCTTGAGTGACCCC	0.577000									Gaucher disease type I				14	27					0	0	1	0	0
AUP1	550	broad.mit.edu	37	2	74754875	74754875	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr2:74754875G>A	ENST00000377526.3	-	8	1138	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C		NM_181575.3	NP_853553.1	Q9Y679	AUP1_HUMAN	ancient ubiquitous protein 1	343						endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	11						GACTGGGGGCGCAATCTGGGG	0.512000													4	194					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41045776	41045776	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chrX:41045776C>T	ENST00000324545.7	+	24	4198	c.3565C>T	c.(3565-3567)Caa>Taa	p.Q1189*	USP9X_ENST00000378308.2_Nonsense_Mutation_p.Q1189*	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1189					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TCAGATCAACCAAGTTACCCA	0.408000													8	147					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111484935	111484935	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr7:111484935C>A	ENST00000428084.1	-	25	2892	c.2620G>T	c.(2620-2622)Gaa>Taa	p.E874*	DOCK4_ENST00000437633.1_Nonsense_Mutation_p.E874*			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	874					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				ACATCTATTTCCTCCAGCACA	0.428000													13	135					2.31682e-05	2.31682e-05	1	1	0
PCDHA10	0	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr5:140237249G>C	ENST00000307360.5	+	1	1616	c.1616G>C	c.(1615-1617)gGg>gCg	p.G539A	PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.G539A(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687000													5	181					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66635840	66635840	+	Silent	SNP	T	T	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr8:66635840T>C	ENST00000401827.3	-	12	1622	c.1179A>G	c.(1177-1179)aaA>aaG	p.K393K	PDE7A_ENST00000396642.3_Silent_p.K393K|PDE7A_ENST00000379419.4_Silent_p.K367K	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	393	Catalytic (By similarity).					cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CCAAATGATATTTTTTTTCTA	0.294000													14	21					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10302293	10302293	+	Missense_Mutation	SNP	A	A	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr3:10302293A>C	ENST00000287652.4	+	3	1938	c.887A>C	c.(886-888)gAc>gCc	p.D296A	TATDN2_ENST00000448281.2_Missense_Mutation_p.D296A|RP11-438J1.1_ENST00000450534.1_3'UTR	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	296						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						ACTGTCATTGACAAATGCTCT	0.473000													4	134					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32164840	32164840	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr22:32164840C>T	ENST00000400246.1	+	7	546	c.404C>T	c.(403-405)gCt>gTt	p.A135V	DEPDC5_ENST00000382112.3_Missense_Mutation_p.A135V|DEPDC5_ENST00000266091.3_Missense_Mutation_p.A135V|DEPDC5_ENST00000536766.1_Missense_Mutation_p.A107V|DEPDC5_ENST00000400249.2_Missense_Mutation_p.A135V|DEPDC5_ENST00000382105.2_Missense_Mutation_p.A135V|DEPDC5_ENST00000382111.2_Missense_Mutation_p.A135V|DEPDC5_ENST00000400242.3_Missense_Mutation_p.A135V|DEPDC5_ENST00000535622.1_Missense_Mutation_p.A135V|DEPDC5_ENST00000400248.1_Missense_Mutation_p.A135V			O75140	DEPD5_HUMAN	DEP domain containing 5	135					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						GTGGAGTTTGCTGGCATCAGG	0.488000													4	134					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033014	82033014	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr16:82033014T>C	ENST00000328945.5	-	3	1011	c.884A>G	c.(883-885)gAg>gGg	p.E295G		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	295					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						GTGAACCATCTCTGTTAGAAA	0.478000													5	96					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77614243	77614243	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr3:77614243T>G	ENST00000461745.1	+	12	2721	c.1821T>G	c.(1819-1821)agT>agG	p.S607R	ROBO2_ENST00000487694.3_Missense_Mutation_p.S623R|ROBO2_ENST00000332191.8_Missense_Mutation_p.S607R	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	607	Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTGACCCAAGTCCCATGTCAG	0.468000													27	68					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058168	11058168	+	RNA	SNP	A	A	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr21:11058168A>T	ENST00000470054.1	-	0	479									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACATCTTTCAGGAGCTTGGT	0.388000													5	161					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25289433	25289433	+	Silent	SNP	C	C	T			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr22:25289433C>T	ENST00000400358.4	+	17	1863	c.1806C>T	c.(1804-1806)acC>acT	p.T602T	SGSM1_ENST00000400359.4_Silent_p.T657T	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	657						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						ATGCACAGACCATGGCTGAGT	0.652000													3	33					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109312	145109313	+	RNA	INS	-	-	A	rs148903206		TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr1:145109312_145109313insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										aaaccaaaaacaaaAAAAAAAG	0.416													3	5	---	---	---	---					
AC023347.1	0	broad.mit.edu	37	2	127069021	127069022	+	RNA	INS	-	-	T	rs140927368	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr2:127069021_127069022insT	ENST00000435352.1	+	0	136																											TAGGAATTTCCTGGTCAAGTCT	0.386													4	3	---	---	---	---					
MAGI1	9223	broad.mit.edu	37	3	65372850	65372851	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr3:65372850_65372851delTC	ENST00000330909.8	-	15	2466_2467	c.2467_2468delGA	c.(2467-2469)afs	p.E823fs	MAGI1_ENST00000402939.2_Intron|MAGI1_ENST00000483466.1_Frame_Shift_Del_p.E823fs|MAGI1_ENST00000497477.2_Intron	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	823	PDZ 4.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GGAATTGATTTCTCTCTCTCTC	0.401													8	68	---	---	---	---					
STAG3L4	0	broad.mit.edu	37	7	66767611	66767611	+	RNA	DEL	T	T	-	rs12531701	by1000genomes	TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr7:66767611delT	ENST00000416602.2	+	0	4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				ACCGGACTGCTTTTTTTTTTT	0.542													3	4	---	---	---	---					
PMS2P3	0	broad.mit.edu	37	7	75142142	75142142	+	RNA	DEL	A	A	-	rs35519730		TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr7:75142142delA	ENST00000418756.1	-	0	991					NR_028059.1															lung(1)	1						tctcaaaaagaaaaaaaaaaa	0.418													3	5	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086237	20086237	+	RNA	DEL	T	T	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr14:20086237delT	ENST00000548261.1	+	0	51																											GGTGTGTGTGTGGGGGGGTAT	0.388													6	9	---	---	---	---					
ZNF106	64397	broad.mit.edu	37	15	42710138	42710145	+	Frame_Shift_Del	DEL	GCAACCAT	GCAACCAT	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr15:42710138_42710145delGCAACCAT	ENST00000263805.4	-	18	5779_5786	c.5453_5460delATGGTTGC	c.(5452-5460)cfs	p.HGC1818fs	ZNF106_ENST00000565611.1_Frame_Shift_Del_p.HGC1003fs|ZNF106_ENST00000565380.1_Frame_Shift_Del_p.HGC1046fs	NM_022473.1	NP_071918.1			zinc finger protein 106																		ATATCAGAGAGCAACCATGCCACTGGAG	0.476													12	25	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102312241	102312241	+	RNA	DEL	A	A	-	rs59860046		TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr15:102312241delA	ENST00000561463.1	+	0	13609																											AGTGGCCGGGAAATTTGCTGT	0.592													5	5	---	---	---	---					
PSG7	5676	broad.mit.edu	37	19	43429531	43429531	+	RNA	DEL	T	T	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr19:43429531delT	ENST00000446844.3	-	0	1726				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				aatatttcaattatcattccc	0.303													2	4	---	---	---	---					
KCNJ14	3770	broad.mit.edu	37	19	48965044	48965044	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr19:48965044delG	ENST00000391884.1	+	1	539	c.63delG	c.(61-63)gcfs	p.A21fs	KCNJ14_ENST00000342291.2_Frame_Shift_Del_p.A21fs			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	21						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		ACAGCCGGGCGGGCGATGAAG	0.746													2	4	---	---	---	---					
IFNGR2	3460	broad.mit.edu	37	21	34799292	34799292	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr21:34799292delT	ENST00000290219.6	+	4	1162	c.514delT	c.(514-516)ttfs	p.F173fs	IFNGR2_ENST00000381995.1_Frame_Shift_Del_p.F192fs|IFNGR2_ENST00000405436.1_Frame_Shift_Del_p.F94fs	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	173	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	CTCCACGGCCTTTTTTTGTTA	0.458													7	388	---	---	---	---					
CYP2D7P1	0	broad.mit.edu	37	22	42540245	42540245	+	RNA	DEL	C	C	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chr22:42540245delC	ENST00000433992.1	-	0	292				CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						GGTGGGGCATCCTCAGGACCT	0.612													2	4	---	---	---	---					
USP9X	8239	broad.mit.edu	37	X	41012243	41012246	+	Frame_Shift_Del	DEL	AATC	AATC	-			TCGA-QR-A70U-01A-11D-A35D-08	TCGA-QR-A70U-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a3547db-d8b6-4da9-9586-080cf4ade52e	eeaad513-715a-4a3e-b710-a8a99aa281ae	g.chrX:41012243_41012246delAATC	ENST00000324545.7	+	14	2439_2442	c.1806_1809delAATC	c.(1804-1809)ttfs	p.LI602fs	USP9X_ENST00000378308.2_Frame_Shift_Del_p.LI602fs	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	602					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						GCCATGACTTAATCAATCAACTTC	0.368													50	136	---	---	---	---					
