Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD36	375248	broad.mit.edu	37	2	97856721	97856721	+	Missense_Mutation	SNP	C	C	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr2:97856721C>A	ENST00000420699.2	+	35	2496	c.2252C>A	c.(2251-2253)tCt>tAt	p.S751Y	ANKRD36_ENST00000461153.2_Missense_Mutation_p.S751Y	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	751										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TCAGTGTCTTCTCAGAAACAA	0.299000													3	11					0.0215528	0.0222263	1	1	0
EGLN1	54583	broad.mit.edu	37	1	231556829	231556829	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:231556829A>G	ENST00000366641.3	-	1	3961	c.806T>C	c.(805-807)aTt>aCt	p.I269T		NM_022051.2	NP_071334.1	Q9GZT9	EGLN1_HUMAN	egl-9 family hypoxia-inducible factor 1	269					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	16		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	GAGCAGCCCAATGGTTTCGCA	0.577000													9	45					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171076862	171076862	+	Missense_Mutation	SNP	G	G	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:171076862G>C	ENST00000367755.4	+	4	479	c.368G>C	c.(367-369)gGc>gCc	p.G123A	FMO3_ENST00000542847.1_Missense_Mutation_p.G103A|FMO3_ENST00000392085.2_Missense_Mutation_p.G123A|FMO3_ENST00000538429.1_Missense_Mutation_p.G60A	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	123					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCAACTACTGGCCAGTGGGAT	0.398000													14	42					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369200	158369200	+	Silent	SNP	G	G	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:158369200G>A	ENST00000334438.1	-	1	56	c.57C>T	c.(55-57)tcC>tcT	p.S19S		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CCCCCAGGCTGGAGAAACCCA	0.458000													10	9					0	0	1	0	0
MBD5	0	broad.mit.edu	37	2	149227977	149227977	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr2:149227977C>G	ENST00000407073.1	+	9	3462	c.2465C>G	c.(2464-2466)cCa>cGa	p.P822R	MBD5_ENST00000404807.1_Missense_Mutation_p.P822R	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	822						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCCTCCACTCCAGTGATACCA	0.423000													16	31					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													5	84					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100912716	100912716	+	Missense_Mutation	SNP	C	C	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr11:100912716C>T	ENST00000325455.5	-	7	4059	c.2606G>A	c.(2605-2607)cGt>cAt	p.R869H	PGR_ENST00000263463.5_Missense_Mutation_p.R767H|PGR_ENST00000534013.1_Missense_Mutation_p.R275H	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	869	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TTGATAGAAACGCTGTGAGCT	0.368000													9	15					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16261761	16261761	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:16261761C>G	ENST00000375759.3	+	11	9230	c.9026C>G	c.(9025-9027)gCa>gGa	p.A3009G		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3009					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGCATCCCAGCAGATCGAACT	0.617000													9	31					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123518383	123518383	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chrX:123518383T>C	ENST00000422452.2	-	30	6461	c.6398A>G	c.(6397-6399)cAa>cGa	p.Q2133R	TENM1_ENST00000371130.3_Missense_Mutation_p.Q2126R|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ATTATCATATTGAATGGTCAT	0.398000													4	117					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18150576	18150576	+	Silent	SNP	C	C	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr17:18150576C>G	ENST00000327031.4	-	21	2808	c.2583G>C	c.(2581-2583)ggG>ggC	p.G861G	FLII_ENST00000545457.2_Silent_p.G806G|FLII_ENST00000579294.1_Silent_p.G850G|FLII_ENST00000578558.1_Intron|FLII_ENST00000379450.4_Silent_p.G775G	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	861					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GTTTCACCTTCCCGGAGAGAC	0.622000													12	30					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215792612	215792612	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:215792612A>G	ENST00000259154.4	+	17	2159	c.1865A>G	c.(1864-1866)cAc>cGc	p.H622R	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	622						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CAGCATAGCCACTTACGAGAA	0.363000													14	75					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													4	100					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39613293	39613293	+	Missense_Mutation	SNP	C	C	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr8:39613293C>A	ENST00000265708.4	-	16	1854	c.1751G>T	c.(1750-1752)aGc>aTc	p.S584I	ADAM2_ENST00000347580.4_Missense_Mutation_p.S565I|ADAM2_ENST00000379853.2_Missense_Mutation_p.S428I|ADAM2_ENST00000521880.1_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	584	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CATCTTTTGGCTGTCTGCATG	0.348000													9	66					0.0477658	0.0477658	1	1	0
MCC	4163	broad.mit.edu	37	5	112824054	112824054	+	Missense_Mutation	SNP	C	C	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr5:112824054C>T	ENST00000408903.3	-	1	473	c.58G>A	c.(58-60)Ggc>Agc	p.G20S		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	548					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity	p.G20S(1)		endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ccgctgccgccgccgccgccg	0.756000													3	10					0	0	1	0	0
CYP2A7	1549	broad.mit.edu	37	19	41387998	41387998	+	Silent	SNP	G	G	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr19:41387998G>A	ENST00000301146.4	-	1	659	c.118C>T	c.(118-120)Ctg>Ttg	p.L40L	CYP2A7_ENST00000291764.3_Silent_p.L40L|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	40						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ATGAAGGGCAGTGGGGTGGGT	0.587000													3	41					0	0	1	0	0
CACYBP	27101	broad.mit.edu	37	1	174977818	174977818	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:174977818T>C	ENST00000367681.2	+	5	1017	c.377T>C	c.(376-378)gTt>gCt	p.V126A	CACYBP_ENST00000405362.1_Missense_Mutation_p.V126A|CACYBP_ENST00000367679.2_Missense_Mutation_p.V169A	NM_001007214.1	NP_001007215.1	Q9HB71	CYBP_HUMAN	calcyclin binding protein	169	CS.|Interaction with SKP1.					beta-catenin destruction complex	protein homodimerization activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)	11						CTGACCCAGGTTGAAAAGGAG	0.333000													10	29					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087339	9087339	+	Missense_Mutation	SNP	C	C	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr19:9087339C>T	ENST00000397910.4	-	1	4679	c.4476G>A	c.(4474-4476)atG>atA	p.M1492I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1492	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGTGTGGACATAGGTGGAA	0.423000													50	65					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54452061	54452061	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr17:54452061T>C	ENST00000566473.2	+	7	905	c.905T>C	c.(904-906)gTa>gCa	p.V302A	ANKFN1_ENST00000318698.2_Missense_Mutation_p.V302A			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	302	Fibronectin type-III.									NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GCAGCTGTAGTAACCAGGTAT	0.448000													19	46					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735860	12735860	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chrX:12735860C>G	ENST00000380682.1	+	16	3421	c.2915C>G	c.(2914-2916)gCt>gGt	p.A972G		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	972					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CACGCCCTGGCTGCTAGGCCA	0.597000													5	78					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	100					0	0	1	0	0
ALKBH1	8846	broad.mit.edu	37	14	78174291	78174291	+	Silent	SNP	C	C	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr14:78174291C>T	ENST00000216489.3	-	1	72	c.57G>A	c.(55-57)ggG>ggA	p.G19G		NM_006020.2	NP_006011.2	Q13686	ALKB1_HUMAN	alkB, alkylation repair homolog 1 (E. coli)	19					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		AGGCGTCCTCCCCGGGCTCAG	0.652000													6	42					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906391	23906391	+	Missense_Mutation	SNP	C	C	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr13:23906391C>A	ENST00000382298.3	-	10	12212	c.11624G>T	c.(11623-11625)cGt>cTt	p.R3875L	SACS_ENST00000382292.3_Missense_Mutation_p.R3875L|SACS_ENST00000402364.1_Missense_Mutation_p.R3125L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3875					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTAACTGTACGCATTTCATT	0.383000													21	107					3.62473e-10	3.98721e-10	1	1	0
WDR64	128025	broad.mit.edu	37	1	241886684	241886684	+	Silent	SNP	C	C	T	rs142859030	by1000genomes	TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:241886684C>T	ENST00000366552.2	+	9	1317	c.1110C>T	c.(1108-1110)gcC>gcT	p.A370A	WDR64_ENST00000437684.2_Silent_p.A370A	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	370										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TCAGTATCGCCGAGATCGTAA	0.418000													4	24					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950986	235950986	+	Missense_Mutation	SNP	G	G	A			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr2:235950986G>A	ENST00000409212.1	+	4	2080	c.1573G>A	c.(1573-1575)Ggg>Agg	p.G525R	SH3BP4_ENST00000344528.4_Missense_Mutation_p.G525R|SH3BP4_ENST00000392011.2_Missense_Mutation_p.G525R			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	525					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GCAGCTGTGGGGGAAGCACCA	0.572000													8	42					0	0	1	0	0
TM2D1	83941	broad.mit.edu	37	1	62190656	62190656	+	Missense_Mutation	SNP	A	A	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:62190656A>C	ENST00000371177.2	-	1	149	c.137T>G	c.(136-138)cTt>cGt	p.L46R	TM2D1_ENST00000294613.5_Missense_Mutation_p.L46R|TM2D1_ENST00000371180.2_Missense_Mutation_p.L108R|TM2D1_ENST00000606498.1_Missense_Mutation_p.L46R			Q9BX74	TM2D1_HUMAN	TM2 domain containing 1	46					apoptosis					large_intestine(2)|lung(3)|ovary(1)	6						CTCGCACTTAAGCGACTCCTC	0.637000													3	34					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91866581	91866581	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr1:91866581T>C	ENST00000370425.3	-	2	157	c.59A>G	c.(58-60)gAt>gGt	p.D20G	HFM1_ENST00000370424.3_5'UTR|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	20							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTCAACTTCATCTGGTTTTTC	0.299000													4	9					0	0	1	0	0
PDE1B	0	broad.mit.edu	37	12	54966508	54966508	+	Missense_Mutation	SNP	C	C	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr12:54966508C>T	ENST00000243052.3	+	7	1154	c.718C>T	c.(718-720)Ctc>Ttc	p.L240F	PDE1B_ENST00000538346.1_Missense_Mutation_p.L199F|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.L220F	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	240	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						TTGCTTCTTGCTCCGCACAGG	0.517000													6	150					0	0	1	0	0
YWHAQ	10971	broad.mit.edu	37	2	9728380	9728380	+	Missense_Mutation	SNP	T	T	C			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr2:9728380T>C	ENST00000381844.4	-	3	659	c.496A>G	c.(496-498)Atc>Gtc	p.I166V	YWHAQ_ENST00000238081.3_Missense_Mutation_p.I166V|YWHAQ_ENST00000474715.1_5'UTR			P27348	1433T_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	166					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		CCCAGGCGGATTGGGTGTGTG	0.423000													4	53					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552237	102552237	+	Silent	SNP	A	A	T			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr14:102552237A>T	ENST00000334701.7	-	4	1034	c.753T>A	c.(751-753)tcT>tcA	p.S251S	HSP90AA1_ENST00000216281.8_Silent_p.S129S|HSP90AA1_ENST00000441629.2_Intron	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	129					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GGCCAATCATAGAGATATCTG	0.448000													39	50					0	0	1	0	0
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr7:20824941_20824943delGCC	ENST00000361443.4	-	3	676_678	c.439_441delGGC	c.(439-441)del	p.G147del	SP8_ENST00000418710.2_In_Frame_Del_p.G165del	NM_198956.2	NP_945194.1	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G165delG(1)|p.G147delG(1)		NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGCGGAGGAgccgccgccgccg	0.729													2	4	---	---	---	---					
IRF7	3665	broad.mit.edu	37	11	613833	613833	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QT-A5XO-01A-11D-A35D-08	TCGA-QT-A5XO-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3410bf2-6b6b-4c73-9e6e-25594f40267f	e1babb7b-cefd-4f13-a63b-b487cac31a74	g.chr11:613833delC	ENST00000397566.1	-	6	1247	c.838delG	c.(838-840)cafs	p.A280fs	IRF7_ENST00000348655.6_Frame_Shift_Del_p.A238fs|IRF7_ENST00000330243.5_Frame_Shift_Del_p.A280fs|IRF7_ENST00000397562.3_5'UTR|IRF7_ENST00000397570.1_Frame_Shift_Del_p.A238fs|IRF7_ENST00000525445.1_Frame_Shift_Del_p.A161fs|IRF7_ENST00000397574.2_Frame_Shift_Del_p.A267fs	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	267					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TACGGCTCTGCCTGGTGCGGG	0.697													2	4	---	---	---	---					
