Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCN8A	6334	broad.mit.edu	37	12	52145212	52145212	+	Silent	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr12:52145212C>T	ENST00000354534.5	+	14	2383	c.2205C>T	c.(2203-2205)tgC>tgT	p.C735C	SCN8A_ENST00000550891.1_Silent_p.C735C|SCN8A_ENST00000545061.1_Silent_p.C735C	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	735					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCTGGGAGTGCCACCCCTACT	0.443000													4	119					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123342198	123342198	+	Splice_Site	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr9:123342198C>T	ENST00000349780.4	-	1	238	c.59_splice	c.e1+1	p.S20_splice	CDK5RAP2_ENST00000360822.3_Splice_Site_p.S20_splice|CDK5RAP2_ENST00000359309.3_Splice_Site_p.S20_splice|CDK5RAP2_ENST00000360190.4_Splice_Site_p.S20_splice	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	20					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CCGGCCGCACCTGCAGCCGCT	0.642000													7	9					0	0	1	0	0
RORC	0	broad.mit.edu	37	1	151786011	151786011	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr1:151786011C>T	ENST00000356728.6	-	6	1110	c.956G>A	c.(955-957)gGc>gAc	p.G319D	RORC_ENST00000318247.6_Missense_Mutation_p.G340D|RORC_ENST00000392697.3_Missense_Mutation_p.G394D|RORC_ENST00000480719.1_5'UTR	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	340	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTCCATAAAGCCTGAGAGCCT	0.602000													13	31					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247055	39247055	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr7:39247055C>T	ENST00000518318.2	+	4	389	c.347C>T	c.(346-348)gCc>gTc	p.A116V	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.A116V|POU6F2_ENST00000559001.1_Missense_Mutation_p.A108V			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	116					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GGCCCCCCAGCCCTCAACCAG	0.577000													31	79					0	0	1	0	0
PRR4	11272	broad.mit.edu	37	12	10999642	10999642	+	Splice_Site	SNP	A	A	G	rs77818542		TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr12:10999642A>G	ENST00000228811.4	-	3	461		c.e3+1		PRR4_ENST00000536668.1_Splice_Site|PRR4_ENST00000540107.1_Splice_Site|PRR4_ENST00000544994.1_Splice_Site	NM_007244.2	NP_009175.2	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal)						visual perception	extracellular space				endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	9						CTGGAATCATACCTGCCACTG	0.423000													3	67					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29554565	29554565	+	Missense_Mutation	SNP	T	T	A			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr17:29554565T>A	ENST00000358273.4	+	20	2733	c.2350T>A	c.(2350-2352)Tgg>Agg	p.W784R	NF1_ENST00000356175.3_Missense_Mutation_p.W784R	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	784			W -> C (in NF1).|W -> R (in NF1).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)|p.H781_Q786del(1)|p.T780_Q786>K(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACATGCAAAATGGGAACAAGC	0.383000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			16	22					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103662557	103662557	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr8:103662557G>C	ENST00000395884.3	-	4	2115	c.1213C>G	c.(1213-1215)Ctg>Gtg	p.L405V	KLF10_ENST00000285407.6_Missense_Mutation_p.L416V	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	416					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			TGTCTGGACAGTTCATCAGAA	0.478000													4	53					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76212110	76212110	+	Silent	SNP	C	C	A			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr17:76212110C>A	ENST00000301633.4	+	3	416	c.285C>A	c.(283-285)atC>atA	p.I95I	BIRC5_ENST00000592734.1_Intron|AC087645.1_ENST00000600484.1_Intron|BIRC5_ENST00000374948.2_Intron|BIRC5_ENST00000350051.3_Intron	NM_001012271.1	NP_001012271.1	O15392	BIRC5_HUMAN	baculoviral IAP repeat containing 5	74					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			gcgggcggatcacgaggtcag	0.562000													3	25					0.115264	0.115264	1	1	0
APBB2	323	broad.mit.edu	37	4	41015773	41015773	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr4:41015773C>T	ENST00000295974.8	-	6	1291	c.662G>A	c.(661-663)gGc>gAc	p.G221D	APBB2_ENST00000506352.1_Missense_Mutation_p.G221D|APBB2_ENST00000513140.1_Missense_Mutation_p.G221D|APBB2_ENST00000508593.1_Missense_Mutation_p.G221D	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	221					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						GGCTACTTGGCCGTCTTCAGG	0.567000													5	368					0	0	1	0	0
PCDHGC3	0	broad.mit.edu	37	5	140856203	140856203	+	Missense_Mutation	SNP	C	C	G			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr5:140856203C>G	ENST00000308177.3	+	1	624	c.520C>G	c.(520-522)Ctg>Gtg	p.L174V	PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCTATGAGCTGAGCCGAAA	0.602000													12	25					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216264046	216264046	+	Silent	SNP	G	G	A			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr2:216264046G>A	ENST00000354785.4	-	21	3651	c.3282C>T	c.(3280-3282)taC>taT	p.Y1094Y	FN1_ENST00000356005.4_Silent_p.Y1094Y|FN1_ENST00000346544.3_Silent_p.Y1094Y|FN1_ENST00000345488.5_Silent_p.Y1094Y|FN1_ENST00000323926.6_Silent_p.Y1094Y|FN1_ENST00000336916.4_Silent_p.Y1094Y|FN1_ENST00000432072.2_Silent_p.Y1094Y|FN1_ENST00000446046.1_Silent_p.Y1094Y|FN1_ENST00000443816.1_Silent_p.Y1094Y|FN1_ENST00000421182.1_Silent_p.Y1094Y|FN1_ENST00000359671.1_Silent_p.Y1094Y|FN1_ENST00000357867.4_Silent_p.Y1094Y|FN1_ENST00000357009.2_Silent_p.Y1094Y			P02751	FINC_HUMAN	fibronectin 1	1094	Fibronectin type-III 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTCGGTGTTGTAAGGTGGAA	0.428000													25	47					0	0	1	0	0
ACADM	34	broad.mit.edu	37	1	76200505	76200505	+	Missense_Mutation	SNP	T	T	A			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr1:76200505T>A	ENST00000370841.4	+	6	854	c.417T>A	c.(415-417)gaT>gaA	p.D139E	ACADM_ENST00000370834.5_Missense_Mutation_p.D172E|ACADM_ENST00000541113.1_Missense_Mutation_p.D103E|ACADM_ENST00000543667.1_Intron|ACADM_ENST00000420607.2_Missense_Mutation_p.D143E	NM_000016.4|NM_001127328.1	NP_000007.1|NP_001120800.1	P11310	ACADM_HUMAN	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	139					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	18						CTGGAAATGATCAACAAAAGA	0.333000													3	16					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24628063	24628063	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr22:24628063G>T	ENST00000327365.4	-	5	1126	c.710C>A	c.(709-711)aCg>aAg	p.T237K	GGT5_ENST00000418439.2_Missense_Mutation_p.T160K|GGT5_ENST00000263112.7_Missense_Mutation_p.T205K|GGT5_ENST00000398292.3_Missense_Mutation_p.T237K	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	237					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						CAGCCTCCCCGTGTAGAAGAC	0.632000													4	6					0.00909568	0.00950912	1	1	0
TRIM48	79097	broad.mit.edu	37	11	55032490	55032490	+	Silent	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr11:55032490C>T	ENST00000417545.2	+	2	245	c.159C>T	c.(157-159)ccC>ccT	p.P53P		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	37						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TTTGCAGGCCCTGTTTCTACC	0.463000													4	141					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64818384	64818384	+	Silent	SNP	A	A	G			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr12:64818384A>G	ENST00000332707.5	+	12	1717	c.1188A>G	c.(1186-1188)gaA>gaG	p.E396E		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	396					intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		CATAGGGTGAAGATGAAGCCA	0.418000													30	53					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72829565	72829565	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr16:72829565C>T	ENST00000268489.5	-	9	7688	c.7016G>A	c.(7015-7017)cGc>cAc	p.R2339H	ZFHX3_ENST00000397992.5_Missense_Mutation_p.R1425H	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2339					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ATCAAAGATGCGCTGAAACAC	0.473000													4	134					0	0	1	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880756	105880756	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr11:105880756G>C	ENST00000301919.4	-	3	1959	c.544C>G	c.(544-546)Cac>Gac	p.H182D		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	182						nucleus											TCATCAATGTGGGGGAAATCG	0.393000													15	60					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43167852	43167852	+	Silent	SNP	C	C	T			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr6:43167852C>T	ENST00000252050.4	+	14	3426	c.3342C>T	c.(3340-3342)ctC>ctT	p.L1114L	CUL9_ENST00000372647.2_Silent_p.L1114L|CUL9_ENST00000354495.3_Silent_p.L1004L	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	1114					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						ACGCACAGCTCTATAGCAACC	0.567000													10	27					0	0	1	0	0
RP11-466F5.6	0	broad.mit.edu	37	1	165677513	165677513	+	RNA	DEL	G	G	-			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr1:165677513delG	ENST00000400982.2	+	0	407					NR_036683.1																						GCCCCTTCCTGGGATACCATG	0.557													2	4	---	---	---	---					
CYP2W1	54905	broad.mit.edu	37	7	1024197	1024197	+	Frame_Shift_Del	DEL	C	C	-			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr7:1024197delC	ENST00000340150.6	+	2	178	c.156delC	c.(154-156)atfs	p.I52fs	CYP2W1_ENST00000308919.7_Frame_Shift_Del_p.I108fs			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	108					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		TCCAGCTCATCCAGCGAGGTG	0.721													2	4	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-RW-A685-01A-11D-A35D-08	TCGA-RW-A685-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26b200cb-3d8c-40f5-9071-0ace6b35150f	04a2d37c-e3b0-4fdc-a546-66cd8a6dc94a	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													4	4	---	---	---	---					
