Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IGHV4-61	0	broad.mit.edu	37	14	107095582	107095582	+	RNA	SNP	G	G	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr14:107095582G>T	ENST00000390630.2	-	0	80																											AGGAGGTCCAGGACTCTCAGA	0.502000													3	37					0.00448238	0.00465478	1	1	0
SPTB	6710	broad.mit.edu	37	14	65237698	65237698	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr14:65237698G>A	ENST00000389722.3	-	26	5756	c.5703C>T	c.(5701-5703)gaC>gaT	p.D1901D	SPTB_ENST00000556626.1_Silent_p.D1901D|SPTB_ENST00000389721.5_Silent_p.D1901D|SPTB_ENST00000389720.3_Silent_p.D1901D|SPTB_ENST00000542895.1_Silent_p.D1901D	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1901					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TATCCGCCGTGTCCACTAGCT	0.642000													17	52					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52797571	52797571	+	Silent	SNP	C	C	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr12:52797571C>T	ENST00000257974.2	-	2	611	c.534G>A	c.(532-534)cgG>cgA	p.R178R		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	178	Coil 1B.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		AGTCCAGCTGCCGCCGAAGGG	0.592000													4	116					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72017892	72017892	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr12:72017892T>C	ENST00000378743.3	-	23	4856	c.4498A>G	c.(4498-4500)Att>Gtt	p.I1500V		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1500					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ACCTGTAAAATTGCCAGTGCA	0.368000													7	369					0	0	1	0	0
IGHV4-61	0	broad.mit.edu	37	14	107095585	107095585	+	RNA	SNP	C	C	G			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr14:107095585C>G	ENST00000390630.2	-	0	77																											AGGTCCAGGACTCTCAGAAAG	0.507000													3	37					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8215731	8215731	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr17:8215731G>C	ENST00000361926.3	+	2	484	c.374G>C	c.(373-375)gGg>gCg	p.G125A	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.G125A	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	125	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AAGCCGTCTGGGTCACCCTGC	0.667000													7	129					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108147534	108147534	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr3:108147534G>T	ENST00000273353.3	-	28	3623	c.3567C>A	c.(3565-3567)gaC>gaA	p.D1189E		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1189						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCTCTTCCATGTCTCGGTGCA	0.493000													6	89					2.7689e-08	3.11501e-08	1	1	0
NCAPD3	23310	broad.mit.edu	37	11	134029868	134029868	+	Silent	SNP	C	C	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr11:134029868C>T	ENST00000534548.2	-	29	3850	c.3786G>A	c.(3784-3786)caG>caA	p.Q1262Q		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1262					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CCTGGACCAGCTGTTCCTGGT	0.552000													26	55					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29624070	29624070	+	Missense_Mutation	SNP	G	G	A	rs79198850		TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr20:29624070G>A	ENST00000278882.3	+	4	474	c.94G>A	c.(94-96)Gct>Act	p.A32T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A37T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A32T														p.A32T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GCAGTTTATGGCTGTCAAATT	0.279000													3	21					0	0	1	0	0
GATAD2B	57459	broad.mit.edu	37	1	153800617	153800617	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr1:153800617G>A	ENST00000368655.4	-	2	450	c.207C>T	c.(205-207)ggC>ggT	p.G69G		NM_020699.2	NP_065750.1	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	69						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	38	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGACACCACTGCCATCCTGTT	0.478000													9	153					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325696	152325696	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr1:152325696G>A	ENST00000388718.5	-	3	4638	c.4566C>T	c.(4564-4566)caC>caT	p.H1522H	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1522							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTTTGGCCGTGAGTGTGTC	0.498000													7	393					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215910616	215910616	+	Missense_Mutation	SNP	A	A	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr2:215910616A>T	ENST00000272895.7	-	7	1036	c.817T>A	c.(817-819)Ttt>Att	p.F273I		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	273					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATTCTGAAACACATTTGGA	0.358000													35	52					0	0	1	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44201956	44201956	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr1:44201956G>A	ENST00000262915.3	+	2	200	c.23G>A	c.(22-24)cGc>cAc	p.R8H	ST3GAL3_ENST00000531816.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000531451.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000531993.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361746.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000528371.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372366.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372365.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372375.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372377.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000332628.6_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372369.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372374.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000545417.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361812.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000533933.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361392.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000351035.3_Missense_Mutation_p.R8H|ST3GAL3_ENST00000347631.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000335430.6_Missense_Mutation_p.R8H|ST3GAL3_ENST00000330208.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372368.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361400.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372362.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372367.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372372.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000353126.3_Missense_Mutation_p.R8H	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	8					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GTATTTGTGCGCAATCTGCTG	0.413000													4	173					0	0	1	0	0
GATA4	2626	broad.mit.edu	37	8	11606509	11606509	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr8:11606509C>T	ENST00000335135.4	+	3	1256	c.698C>T	c.(697-699)aCg>aTg	p.T233M	GATA4_ENST00000532059.1_Missense_Mutation_p.T234M|GATA4_ENST00000528712.1_Missense_Mutation_p.T27M	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	233					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding	p.T233M(1)		central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CGAGATGGGACGGGTCACTAT	0.587000													4	87					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134183876	134183876	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr11:134183876G>T	ENST00000431683.2	+	17	1621	c.1621G>T	c.(1621-1623)Ggc>Tgc	p.G541C		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	541					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTCCCTGGAGGGCTTTACCAT	0.488000													4	23					1.23904e-05	1.33816e-05	1	1	0
BCAS1	8537	broad.mit.edu	37	20	52674691	52674691	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr20:52674691G>A	ENST00000395961.3	-	3	241	c.75C>T	c.(73-75)gaC>gaT	p.D25D	BCAS1_ENST00000371435.2_Silent_p.D25D|BCAS1_ENST00000371440.3_Silent_p.D25D|BCAS1_ENST00000411563.1_Intron	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	25						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CAGACGCGTTGTCCTGAAACA	0.502000													11	46					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30047543	30047543	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr14:30047543G>A	ENST00000331968.5	-	17	2687	c.2458C>T	c.(2458-2460)Ctg>Ttg	p.L820L	PRKD1_ENST00000415220.2_Silent_p.L828L	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	820	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTTACTTGCAGCAAATTGTTG	0.333000													29	35					0	0	1	0	0
IGHG2	0	broad.mit.edu	37	14	106109985	106109985	+	RNA	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr14:106109985G>A	ENST00000390545.2	-	0	632																											TGGTTTTCTCGATGGGGGCTG	0.627000													10	316					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1263681	1263681	+	Nonsense_Mutation	SNP	C	C	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr11:1263681C>A	ENST00000447027.1	+	31	5638	c.5580C>A	c.(5578-5580)tgC>tgA	p.C1860*	MUC5B_ENST00000529681.1_Nonsense_Mutation_p.C1857*|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1857	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGCTGACCTGCAAGAACGAAG	0.592000													3	40					0.115264	0.115264	1	1	0
APOL2	23780	broad.mit.edu	37	22	36624072	36624072	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr22:36624072G>C	ENST00000249066.6	-	6	868	c.392C>G	c.(391-393)aCc>aGc	p.T131S	APOL2_ENST00000451256.2_Missense_Mutation_p.T243S|APOL2_ENST00000358502.5_Missense_Mutation_p.T131S	NM_145637.1	NP_663612.1	Q9BQE5	APOL2_HUMAN	apolipoprotein L, 2	131					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(2)	9						GCCGAGGAGGGTCAGGATGCC	0.582000													16	48					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199407	4199407	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr4:4199407G>A	ENST00000296358.4	-	5	1178	c.1154C>T	c.(1153-1155)cCg>cTg	p.P385L		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	385					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTTGCGGGCCGGATTTTTGGA	0.587000													5	69					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000360232.4_Silent_p.Q179Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|FOXP2_ENST00000378237.3_Silent_p.Q179Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000393494.2_Silent_p.Q179Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													4	63					0	0	1	0	0
SSB	6741	broad.mit.edu	37	2	170665008	170665008	+	Frame_Shift_Del	DEL	A	A	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr2:170665008delA	ENST00000409333.1	+	7	818	c.571delA	c.(571-573)aafs	p.K192fs	SSB_ENST00000260956.4_Frame_Shift_Del_p.K192fs			P05455	LA_HUMAN	Sjogren syndrome antigen B (autoantigen La)	192					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			endometrium(3)|large_intestine(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						TTACTTTGCCAAAAAAAATGA	0.323													7	121	---	---	---	---					
SH3BP5	9467	broad.mit.edu	37	3	15373833	15373835	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr3:15373833_15373835delTCC	ENST00000383791.3	-	1	301_303	c.81_83delGGA	c.(79-84)gaa>ga	p.EE27del	SH3BP5_ENST00000465894.2_Intron|SH3BP5_ENST00000408919.3_Intron|SH3BP5_ENST00000253688.5_5'UTR|SH3BP5_ENST00000426925.1_Intron	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	27	Glu-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						catcccctcttcctcctcctcct	0.719													3	5	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32444350	32444352	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr5:32444350_32444352delGCC	ENST00000265069.8	-	2	222_224	c.120_122delGGC	c.(118-123)gct>gc	p.AA42del		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	42	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		TTGGgccgcagccgccgccgccg	0.680													2	4	---	---	---	---					
FABP5P3	0	broad.mit.edu	37	7	152140121	152140121	+	RNA	DEL	T	T	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr7:152140121delT	ENST00000477993.1	+	0	876					NR_002935.1																						TGTTTCTTTCTTTTTTTTTTC	0.328													2	4	---	---	---	---					
ITGB1	3688	broad.mit.edu	37	10	33217043	33217045	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr10:33217043_33217045delTCC	ENST00000396033.2	-	5	659_661	c.524_526delGGA	c.(523-528)att>a	p.RI175del	ITGB1_ENST00000484088.1_Intron|ITGB1_ENST00000423113.1_In_Frame_Del_p.RI175del|ITGB1_ENST00000302278.3_In_Frame_Del_p.RI175del|ITGB1_ENST00000374956.4_In_Frame_Del_p.RI175del	NM_133376.2	NP_596867.1	P05556	ITB1_HUMAN	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	175	VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TCCGAAGTAATCCTCCTCATTTC	0.355													45	107	---	---	---	---					
CBL	867	broad.mit.edu	37	11	119077233	119077235	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr11:119077233_119077235delCAC	ENST00000264033.4	+	1	482_484	c.106_108delCAC	c.(106-108)del	p.H42del		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	42					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTTCCAGCCGcaccaccaccacc	0.675			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				2	4	---	---	---	---					
snoU13	0	broad.mit.edu	37	13	20449422	20449423	+	RNA	INS	-	-	A			TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr13:20449422_20449423insA	ENST00000459056.1	+	0	96_97																											gcacattactgaaaaaaaaaat	0.446													3	4	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131536	17131537	+	RNA	INS	-	-	CTG	rs34452519		TCGA-RW-A686-06A-11D-A35D-08	TCGA-RW-A686-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	779079b5-a036-417c-8bbe-903d3272bce9	b02dc736-4433-4a57-99f0-6ca1e83e00b3	g.chr22:17131536_17131537insCTG	ENST00000426585.1	+	0	2562_2563																											TGCCCACTCTTCTGGTCTCATG	0.540													3	4	---	---	---	---					
