Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OTUD3	23252	broad.mit.edu	37	1	20232993	20232993	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr1:20232993G>A	ENST00000375120.3	+	7	905	c.904G>A	c.(904-906)Ggc>Agc	p.G302S		NM_015207.1	NP_056022.1	Q5T2D3	OTUD3_HUMAN	OTU domain containing 3	302										breast(1)|kidney(2)|large_intestine(4)|lung(1)|skin(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000276)|Lung NSC(340;0.000338)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.12e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.000408)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGAGGGTGGCAGTGGTGC	0.468000													5	8					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178358732	178358732	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr5:178358732A>G	ENST00000361362.2	+	5	948	c.418A>G	c.(418-420)Att>Gtt	p.I140V	ZFP2_ENST00000520301.1_Missense_Mutation_p.I140V|ZFP2_ENST00000503510.2_Missense_Mutation_p.I140V|ZFP2_ENST00000523286.1_Missense_Mutation_p.I140V	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GAAACACTTCATTGAACGATC	0.413000													25	29					0	0	1	0	0
LIMS2	55679	broad.mit.edu	37	2	128412102	128412102	+	Silent	SNP	G	G	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr2:128412102G>A	ENST00000409455.1	-	4	875	c.240C>T	c.(238-240)ggC>ggT	p.G80G	LIMS2_ENST00000409808.2_Silent_p.G80G|LIMS2_ENST00000545738.2_Silent_p.G107G|LIMS2_ENST00000355119.4_Silent_p.G85G|LIMS2_ENST00000410011.1_Silent_p.G80G|LIMS2_ENST00000324938.5_Silent_p.G109G			Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	85	LIM zinc-binding 2.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		TGATGACGCGGCCAATGATGA	0.607000													4	86					0	0	1	0	0
PRMT1	0	broad.mit.edu	37	19	50185323	50185323	+	Splice_Site	SNP	G	G	C			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr19:50185323G>C	ENST00000532489.1	+	4	716		c.e4+1		PRMT1_ENST00000454376.2_Splice_Site|PRMT1_ENST00000391851.4_Splice_Site			Q8WUW5	Q8WUW5_HUMAN	protein arginine methyltransferase 1							cytoplasm	protein methyltransferase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(2)	12		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		GGTCATCGGGGTGAGTCTCCA	0.682000													3	42					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68934377	68934377	+	Splice_Site	SNP	T	T	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr8:68934377T>A	ENST00000288368.4	+	4	718		c.e4+2		PREX2_ENST00000529398.1_Splice_Site	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2						G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTTCTTTTGGTAAGTGTATAT	0.338000													11	19					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34205716	34205716	+	Silent	SNP	C	C	T			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr20:34205716C>T	ENST00000374273.3	+	4	604	c.492C>T	c.(490-492)atC>atT	p.I164I	SPAG4_ENST00000462896.1_Intron	NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	164					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity	p.I164I(1)		NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCTGTTCCATCCGCTTCCTGT	0.637000													22	46					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38950323	38950323	+	Silent	SNP	C	C	T			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr5:38950323C>T	ENST00000357387.3	-	31	3657	c.3627G>A	c.(3625-3627)acG>acA	p.T1209T	RICTOR_ENST00000296782.5_Silent_p.T1209T	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1209					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TATGTGAGCTCGTTGAACTTT	0.393000													4	178					0	0	1	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032334	46032334	+	Missense_Mutation	SNP	C	C	T	rs141295608	byFrequency	TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr21:46032334C>T	ENST00000334662.2	+	1	339	c.317C>T	c.(316-318)cCg>cTg	p.P106L	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	106	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						AGCTGCCAGCCGGCTTGCTGC	0.642000													30	61					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143053779	143053779	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr7:143053779G>A	ENST00000409408.1	-	6	2571	c.863C>T	c.(862-864)gCg>gTg	p.A288V	FAM131B_ENST00000409346.1_Missense_Mutation_p.A288V|FAM131B_ENST00000409578.1_Missense_Mutation_p.A304V|FAM131B_ENST00000409222.3_Missense_Mutation_p.A288V|FAM131B_ENST00000443739.2_Missense_Mutation_p.A316V			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	288										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					CCGGCATCCCGCATCCTCTTC	0.627000													4	151					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000341724.6_Silent_p.Q1188Q|NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													6	56					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29528481	29528481	+	Nonsense_Mutation	SNP	C	C	G			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr17:29528481C>G	ENST00000358273.4	+	11	1621	c.1238C>G	c.(1237-1239)tCa>tGa	p.S413*	NF1_ENST00000356175.3_Nonsense_Mutation_p.S413*|NF1_ENST00000431387.4_Nonsense_Mutation_p.S413*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	413					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTGGTAAATTCACTCCATCGA	0.294000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			40	46					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000537140.1_Intron|CADM1_ENST00000331581.6_Silent_p.T343T|CADM1_ENST00000452722.2_Silent_p.T343T|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000542447.2_Intron			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													3	41					0.00909568	0.00955046	1	1	0
OR10A3	26496	broad.mit.edu	37	11	7960834	7960834	+	Silent	SNP	C	C	T			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr11:7960834C>T	ENST00000360759.3	-	1	307	c.234G>A	c.(232-234)acG>acA	p.T78T		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCATTTCAGGCGTAATGACTG	0.448000													13	77					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25016897	25016897	+	Missense_Mutation	SNP	A	A	T			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr22:25016897A>T	ENST00000400382.1	+	9	1348	c.593A>T	c.(592-594)gAt>gTt	p.D198V	GGT1_ENST00000400383.1_Missense_Mutation_p.D198V|GGT1_ENST00000248923.4_Missense_Mutation_p.D198V|GGT1_ENST00000406383.2_Missense_Mutation_p.D198V|GGT1_ENST00000400380.1_Missense_Mutation_p.D198V|GGT1_ENST00000466310.1_Intron			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	198					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TTCTGCCGGGATAGAAAGGTG	0.642000													3	20					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28919665	28919665	+	Nonsense_Mutation	SNP	C	C	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr13:28919665C>A	ENST00000282397.4	-	16	2523	c.2272G>T	c.(2272-2274)Gag>Tag	p.E758*	FLT1_ENST00000540678.1_5'UTR	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	758					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTGATCAGCTCCAGATTAGAC	0.403000													4	15					1	1	1	1	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	44					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	RNA	SNP	G	G	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr19:53958826G>A	ENST00000454407.1	+	0	1518							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418000													4	135					0	0	1	0	0
CSRNP1	64651	broad.mit.edu	37	3	39188103	39188105	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr3:39188103_39188105delGAG	ENST00000273153.5	-	2	246_248	c.69_71delCTC	c.(67-72)tct>tc	p.SS25del	CSRNP1_ENST00000514182.1_In_Frame_Del_p.SS25del	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	25	Ser-rich.				apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						CCCAGAGGAAGAGGAGGAGGAGG	0.616													2	4	---	---	---	---					
CPSF7	79869	broad.mit.edu	37	11	61183138	61183148	+	Splice_Site	DEL	CTGCACTGGCT	CTGCACTGGCT	-			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr11:61183138_61183148delCTGCACTGGCT	ENST00000340437.4	-	7	1283_1293	c.1213_splice	c.e7+1	p.GASAG401_splice	CPSF7_ENST00000439958.3_Splice_Site_p.GASAG349_splice|CPSF7_ENST00000394888.4_Splice_Site_p.GASAG358_splice|CPSF7_ENST00000448745.1_Splice_Site_p.GASAG349_splice	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	358					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						ACTGAGTTACCTGCACTGGCTCCAGATACTG	0.436													10	28	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53404542	53404543	+	RNA	INS	-	-	A			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr16:53404542_53404543insA	ENST00000565421.1	-	0	410																											TCTCCTTTCTCAAACTTAACCT	0.327													8	31	---	---	---	---					
RP11-1055B8.7	0	broad.mit.edu	37	17	79423466	79423467	+	Frame_Shift_Ins	INS	-	-	G			TCGA-RW-A7D0-01A-11D-A35D-08	TCGA-RW-A7D0-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	99293d59-23c9-46cf-bdaf-00c2b51a02bf	023921e3-188f-4540-9b31-b6ebf8d992fd	g.chr17:79423466_79423467insG	ENST00000307745.7	+	20	4713_4714	c.4713_4714insG	c.(4711-4716)ccggggfs	p.PG1571fs																								AGGCTACCCCCGGGGGGCGCAT	0.683													2	4	---	---	---	---					
