Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BIRC6	57448	broad.mit.edu	37	2	32693033	32693033	+	Nonsense_Mutation	SNP	C	C	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr2:32693033C>G	ENST00000421745.2	+	28	5768	c.5634C>G	c.(5632-5634)taC>taG	p.Y1878*		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1878					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TAGGATTTTACTATGGTCATA	0.383000													14	15					0	0	1	0	0
IWS1	55677	broad.mit.edu	37	2	128262518	128262518	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr2:128262518A>G	ENST00000295321.4	-	3	1220	c.961T>C	c.(961-963)Tcc>Ccc	p.S321P	IWS1_ENST00000455721.2_Missense_Mutation_p.S328P|AC010976.2_ENST00000599001.1_RNA	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	321	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TTGTGTCTGGACGCATCCTCA	0.517000													66	104					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186379809	186379809	+	Silent	SNP	A	A	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr4:186379809A>G	ENST00000307588.3	-	6	2007	c.1932T>C	c.(1930-1932)ctT>ctC	p.L644L	CCDC110_ENST00000393540.3_Silent_p.L607L|CCDC110_ENST00000510617.1_Silent_p.L644L	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	644						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		ATGTTGTTTCAAGGTTGAGTT	0.338000													7	68					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882283	228882283	+	Missense_Mutation	SNP	T	T	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr2:228882283T>A	ENST00000392056.3	-	7	3333	c.3287A>T	c.(3286-3288)tAt>tTt	p.Y1096F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.Y1096F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1096						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTGTTGACATAGGCCCTGGC	0.602000													5	40					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27406652	27406652	+	Silent	SNP	A	A	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr10:27406652A>C	ENST00000326799.3	-	16	1891	c.1743T>G	c.(1741-1743)ccT>ccG	p.P581P	YME1L1_ENST00000375972.3_Silent_p.P491P|YME1L1_ENST00000376016.3_Silent_p.P524P	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	581					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TTCTTCTTTCAGGCCCTAAGA	0.323000													22	39					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9000200	9000200	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr19:9000200G>C	ENST00000397910.4	-	55	40760	c.40557C>G	c.(40555-40557)ttC>ttG	p.F13519L	MUC16_ENST00000380951.5_Missense_Mutation_p.F160L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13521	SEA 10.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTGTTCTTGAACACAGGCC	0.562000													26	53					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151260658	151260658	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr1:151260658C>T	ENST00000368879.2	+	2	1989	c.1891C>T	c.(1891-1893)Cct>Tct	p.P631S		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTGGCCTTGCCTGCCTTGGG	0.642000													23	53					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32480574	32480574	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr12:32480574G>C	ENST00000548411.1	+	5	1366	c.1185G>C	c.(1183-1185)aaG>aaC	p.K395N	BICD1_ENST00000281474.5_Missense_Mutation_p.K395N	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	395					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			ACGGGGAGAAGGGCCGGGACT	0.577000													11	24					0	0	1	0	0
ZNF252P	0	broad.mit.edu	37	8	146221048	146221048	+	RNA	SNP	C	C	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr8:146221048C>T	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						GCTTTCTTGCCAGAAATGATC	0.498000													3	0					0	0	1	0	0
TRIM17	51127	broad.mit.edu	37	1	228596255	228596255	+	Missense_Mutation	SNP	C	C	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr1:228596255C>A	ENST00000366697.2	-	6	2037	c.1081G>T	c.(1081-1083)Ggg>Tgg	p.G361W	TRIM17_ENST00000295033.3_Missense_Mutation_p.G361W|RP11-245P10.4_ENST00000436779.1_RNA|TRIM17_ENST00000366698.2_Missense_Mutation_p.G361W			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	361	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				AACGCGTCCCCGGTGATGTTC	0.627000													17	32					9.16793e-09	9.69181e-09	1	1	0
WT1	7490	broad.mit.edu	37	11	32450088	32450088	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr11:32450088G>T	ENST00000332351.3	-	2	1008	c.724C>A	c.(724-726)Cac>Aac	p.H242N	WT1_ENST00000530998.1_Missense_Mutation_p.H30N|WT1_ENST00000448076.3_Missense_Mutation_p.H242N|WT1_ENST00000379079.2_Missense_Mutation_p.H30N	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	174					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.?(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TTGAATGAGTGGTTGGGGAAC	0.632000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				6	15					0.00198382	0.00198382	1	1	0
CDK5RAP1	51654	broad.mit.edu	37	20	31984647	31984647	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr20:31984647G>A	ENST00000357886.4	-	2	377	c.224C>T	c.(223-225)cCt>cTt	p.P75L	CDK5RAP1_ENST00000473997.1_5'UTR|CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.P75L|CDK5RAP1_ENST00000452723.3_5'UTR|CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.P75L|CDK5RAP1_ENST00000339269.5_Missense_Mutation_p.P75L			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	75	CDK5 activation inhibition.				brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						CTTCTCCTGAGGAGCTGAGGC	0.493000													48	64					0	0	1	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66521051	66521051	+	Splice_Site	SNP	A	A	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr17:66521051A>G	ENST00000589228.1	+	6	630		c.e6-1		PRKAR1A_ENST00000358598.2_Splice_Site|PRKAR1A_ENST00000392711.1_Splice_Site|PRKAR1A_ENST00000586397.1_Splice_Site|PRKAR1A_ENST00000588188.2_Splice_Site|PRKAR1A_ENST00000536854.2_Splice_Site	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					ACCCTCTTTTAGGTGATGAAG	0.289000			"""T, Mis, N, F, S"""	RET	papillary thyroid	"""myxoma, endocrine, papillary thyroid"""			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				56	95					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89478273	89478273	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr3:89478273G>A	ENST00000336596.2	+	12	2317	c.2092G>A	c.(2092-2094)Gtc>Atc	p.V698I	EPHA3_ENST00000494014.1_Missense_Mutation_p.V698I	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	698	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AGTTATGATTGTCACAGAATA	0.294000										TSP Lung(6;0.00050)			36	57					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75893251	75893251	+	Missense_Mutation	SNP	C	C	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr6:75893251C>A	ENST00000322507.8	-	10	1715	c.1406G>T	c.(1405-1407)aGt>aTt	p.S469I	COL12A1_ENST00000483888.2_Missense_Mutation_p.S469I|COL12A1_ENST00000416123.2_Missense_Mutation_p.S469I|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	469	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.S469I(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AATTTCAAAACTTTTTACAAG	0.358000													36	52					4.34311e-12	4.72632e-12	1	1	0
FAM86DP	0	broad.mit.edu	37	3	75475709	75475709	+	RNA	SNP	T	T	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr3:75475709T>C	ENST00000459803.1	-	0	820					NR_024241.1													p.I261V(1)									CTCCGCAGGATCCCGACCAGC	0.562000													4	53					0	0	1	0	0
URM1	81605	broad.mit.edu	37	9	131140374	131140374	+	Missense_Mutation	SNP	A	A	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr9:131140374A>T	ENST00000372850.1	+	2	115	c.95A>T	c.(94-96)cAg>cTg	p.Q32L	URM1_ENST00000372847.1_Missense_Mutation_p.R46W|URM1_ENST00000452446.1_Missense_Mutation_p.Q32L|URM1_ENST00000483206.1_3'UTR|URM1_ENST00000372853.4_Missense_Mutation_p.Q32L			Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1	32					tRNA thio-modification|tRNA wobble uridine modification		protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	5						TTGCCTGGACAGGAGGAACCC	0.537000													18	37					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187521348	187521348	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr4:187521348G>T	ENST00000441802.2	-	22	12016	c.11807C>A	c.(11806-11808)aCa>aAa	p.T3936K		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3936	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CCCTGGGGCTGTGCCCGATGC	0.512000										HNSCC(5;0.00058)			14	21					0.00185496	0.00190648	1	1	0
ABCA2	20	broad.mit.edu	37	9	139911685	139911685	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr9:139911685G>A	ENST00000265662.5	-	18	2663	c.2516C>T	c.(2515-2517)gCg>gTg	p.A839V	ABCA2_ENST00000341511.6_Missense_Mutation_p.A839V|ABCA2_ENST00000371605.3_Missense_Mutation_p.A838V			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	838					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CTTATCATGCGCCACCTCCTC	0.652000													28	26					0	0	1	0	0
R3HDML	140902	broad.mit.edu	37	20	42965958	42965958	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr20:42965958G>A	ENST00000217043.2	+	1	333	c.161G>A	c.(160-162)cGg>cAg	p.R54Q		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	54						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			AGGTACCGCCGGAAGCGCCAC	0.592000													25	28					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28909760	28909760	+	Silent	SNP	C	C	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr16:28909760C>T	ENST00000395503.4	+	14	1936	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F	ATP2A1_ENST00000357084.3_Silent_p.F584F|ATP2A1_ENST00000536376.1_Silent_p.F459F	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	584					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						CTGCCAGGTTCCTGGAGTATG	0.652000													5	26					0	0	1	0	0
TMEM8B	51754	broad.mit.edu	37	9	35853200	35853200	+	Silent	SNP	C	C	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr9:35853200C>G	ENST00000377988.2	+	12	2317	c.1029C>G	c.(1027-1029)ctC>ctG	p.L343L	TMEM8B_ENST00000377991.4_Silent_p.L343L	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	343					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						GACATGGACTCTGGAACCTGC	0.607000													59	79					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196387237	196387237	+	Silent	SNP	C	C	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr3:196387237C>T	ENST00000328557.4	+	3	926	c.723C>T	c.(721-723)ttC>ttT	p.F241F		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		TGGAGTGGTTCCTCGCGACCG	0.632000													19	27					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39118252	39118252	+	Silent	SNP	T	T	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr9:39118252T>C	ENST00000297668.6	-	14	2158	c.2085A>G	c.(2083-2085)ggA>ggG	p.G695G	CNTNAP3_ENST00000358144.2_Silent_p.G607G|CNTNAP3_ENST00000377659.1_Silent_p.G694G|CNTNAP3_ENST00000323947.7_Silent_p.G601G|CNTNAP3_ENST00000377656.2_Silent_p.G694G	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	695	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCAGTGGGGTTCCATCTGAAA	0.473000													38	63					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45386413	45386413	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr15:45386413T>C	ENST00000389039.6	-	34	4967	c.4582A>G	c.(4582-4584)Aag>Gag	p.K1528E	DUOX2_ENST00000603300.1_Missense_Mutation_p.K1528E			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1528					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TGACAGGCCTTCTCTACATTC	0.577000													10	20					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129537028	129537028	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr10:129537028G>A	ENST00000388920.4	+	2	795	c.756G>A	c.(754-756)atG>atA	p.M252I		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	252					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				CTTCTGCTATGAGCGCTCTGG	0.711000													6	7					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74339086	74339086	+	Silent	SNP	T	T	C			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr13:74339086T>C	ENST00000377669.2	-	5	884	c.858A>G	c.(856-858)caA>caG	p.Q286Q	KLF12_ENST00000377666.4_Silent_p.Q286Q	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	286					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		aaggaaacttttgattattca	0.373000													58	88					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140641376	140641376	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr4:140641376G>A	ENST00000509479.2	-	5	3374	c.2518C>T	c.(2518-2520)Ccc>Tcc	p.P840S	MGST2_ENST00000515137.1_Intron	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	836	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					TTCTGGGAGGGTCCTATTCCC	0.592000													71	107					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													3	53					0	0	1	0	0
SHISA3	152573	broad.mit.edu	37	4	42403414	42403414	+	Silent	SNP	C	C	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr4:42403414C>G	ENST00000319234.4	+	2	881	c.663C>G	c.(661-663)ctC>ctG	p.L221L		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	221					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						CTTACCCCCTCCAGCAGGAGC	0.597000													12	41					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17619599	17619599	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr22:17619599A>G	ENST00000336737.4	-	7	801	c.776T>C	c.(775-777)cTg>cCg	p.L259P	CECR5_ENST00000399852.3_Intron|CECR5_ENST00000155674.5_Missense_Mutation_p.L229P	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	259							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				AATGGTTTCCAGGCACAGCAG	0.542000													56	92					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84693464	84693464	+	Silent	SNP	T	T	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr16:84693464T>A	ENST00000564996.1	+	4	1377	c.1236T>A	c.(1234-1236)tcT>tcA	p.S412S	KLHL36_ENST00000258157.5_Intron	NM_024731.2	NP_079007.2	Q8N4N3	KLH36_HUMAN	kelch-like family member 36	412										endometrium(3)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						GAGCGCTCTCTTCAGTAGAGA	0.572000													28	52					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7129360	7129360	+	Missense_Mutation	SNP	G	G	A	rs147610025		TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr17:7129360G>A	ENST00000005340.5	-	15	2317	c.2035C>T	c.(2035-2037)Ccc>Tcc	p.P679S	DVL2_ENST00000575458.1_Missense_Mutation_p.P673S	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	679					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						ACCATCATGGGGTTGTAGGGG	0.672000													19	26					0	0	1	0	0
HSPA1L	0	broad.mit.edu	37	6	31777995	31777995	+	Silent	SNP	G	G	A			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr6:31777995G>A	ENST00000375654.4	-	2	1944	c.1755C>T	c.(1753-1755)gtC>gtT	p.V585V	HSPA1L_ENST00000417199.3_Silent_p.V585V	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	585					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CCAGTTGATTGACCTCCAGCC	0.408000													4	131					0	0	1	0	0
AC019118.2	0	broad.mit.edu	37	2	2910722	2910723	+	RNA	INS	-	-	T			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr2:2910722_2910723insT	ENST00000457478.1	-	0	594																											tccaccccctctccccagccca	0.708													3	3	---	---	---	---					
SOHLH1	402381	broad.mit.edu	37	9	138586951	138586951	+	Frame_Shift_Del	DEL	C	C	-			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr9:138586951delC	ENST00000298466.5	-	6	880	c.820delG	c.(820-822)ctfs	p.A275fs	SOHLH1_ENST00000425225.1_Frame_Shift_Del_p.A275fs	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	275					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		AGAGGTGCAGCCCCCATGGCC	0.711													2	4	---	---	---	---					
DHX37	57647	broad.mit.edu	37	12	125465270	125465272	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr12:125465270_125465272delCTC	ENST00000308736.2	-	4	600_602	c.502_504delGAG	c.(502-504)del	p.E168del		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	168							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.E168delE(3)		breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCGATTCCGActcctcctcctcc	0.690													4	6	---	---	---	---					
PAPOLA	10914	broad.mit.edu	37	14	97022548	97022548	+	Frame_Shift_Del	DEL	A	A	-			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chr14:97022548delA	ENST00000216277.8	+	19	2022	c.1802delA	c.(1801-1803)cafs	p.Q601fs	PAPOLA_ENST00000392990.2_Frame_Shift_Del_p.Q601fs	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	601	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACTGCCACACAACCAGCCATT	0.408													91	131	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76937831	76937834	+	Frame_Shift_Del	DEL	GGTC	GGTC	-			TCGA-RW-A8AZ-01A-11D-A35D-08	TCGA-RW-A8AZ-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec9933fb-3414-4b9d-b130-f2bfac80bd56	6925a666-cb03-4e59-9a60-4246a41f30dd	g.chrX:76937831_76937834delGGTC	ENST00000373344.5	-	9	3128_3131	c.2914_2917delGACC	c.(2914-2919)agfs	p.DQ972fs	ATRX_ENST00000395603.3_Frame_Shift_Del_p.DQ934fs|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	972					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TCATCGCTCTGGTCTTTCTTTAGG	0.328			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						179	37	---	---	---	---					
