Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RBL1	5933	broad.mit.edu	37	20	35632208	35632208	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr20:35632208C>T	ENST00000373664.3	-	21	2999	c.2933G>A	c.(2932-2934)cGc>cAc	p.R978H	RBL1_ENST00000344359.3_Missense_Mutation_p.R978H	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	978					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				CTGGGAAATGCGGCGTGGTGA	0.453000													3	47					0	0	1	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153312923	153312923	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr1:153312923C>T	ENST00000368739.3	-	7	1104	c.746G>A	c.(745-747)cGc>cAc	p.R249H	PGLYRP4_ENST00000359650.5_Missense_Mutation_p.R253H			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	253					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GACCAGCAGGCGGCACTCATC	0.542000													6	68					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292770	102292770	+	RNA	SNP	C	C	T	rs149751844	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr15:102292770C>T	ENST00000561463.1	+	0	816																											AGCGGCGCGACGAGATGCTGC	0.597000													4	24					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99521448	99521448	+	Missense_Mutation	SNP	C	C	T	rs143262029		TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr9:99521448C>T	ENST00000375231.1	-	6	2314	c.1664G>A	c.(1663-1665)cGa>cAa	p.R555Q	ZNF510_ENST00000223428.4_Missense_Mutation_p.R555Q			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				ATGATCTTTTCGCCAGAAGGA	0.413000													20	77					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													4	68					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													3	22					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43820463	43820463	+	Silent	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr15:43820463C>T	ENST00000382031.1	+	5	7537	c.7506C>T	c.(7504-7506)acC>acT	p.T2502T	MAP1A_ENST00000399453.1_Silent_p.T2264T|MAP1A_ENST00000300231.5_Silent_p.T2264T			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2264						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CTGAGGCTACCACGCCTGTGA	0.622000													42	38					0	0	1	0	0
RBM23	0	broad.mit.edu	37	14	23371511	23371511	+	Silent	SNP	G	G	A			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr14:23371511G>A	ENST00000359890.3	-	11	1206	c.1011C>T	c.(1009-1011)ggC>ggT	p.G337G	RBM23_ENST00000555209.1_Silent_p.G87G|RBM23_ENST00000542016.2_Silent_p.G167G|RBM23_ENST00000399922.2_Silent_p.G321G|RBM23_ENST00000346528.5_Silent_p.G303G	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	337	RRM 2.				mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		CAGTCACATGGCCAACCCTCA	0.552000													3	38					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	20					0	0	1	0	0
EPO	2056	broad.mit.edu	37	7	100320669	100320669	+	Silent	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr7:100320669C>T	ENST00000252723.2	+	5	676	c.495C>T	c.(493-495)ttC>ttT	p.F165F		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	165					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CTGACACTTTCCGCAAACTCT	0.567000													86	45					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82308561	82308561	+	Missense_Mutation	SNP	T	T	C			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr9:82308561T>C	ENST00000376520.4	+	8	1433	c.605T>C	c.(604-606)cTc>cCc	p.L202P	TLE4_ENST00000376544.3_Missense_Mutation_p.L202P|TLE4_ENST00000376534.4_Intron|TLE4_ENST00000376552.2_Intron|TLE4_ENST00000265284.6_Intron|TLE4_ENST00000376537.4_Intron			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AGAGACAAACTCAACCACAAA	0.433000													7	11					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112522827	112522827	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr6:112522827G>A	ENST00000230538.7	-	5	882	c.485C>T	c.(484-486)gCt>gTt	p.A162V	LAMA4_ENST00000389463.4_Missense_Mutation_p.A162V|LAMA4_ENST00000424408.2_Missense_Mutation_p.A162V|LAMA4_ENST00000524032.1_5'UTR|LAMA4_ENST00000522006.1_Missense_Mutation_p.A162V	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	162	Laminin EGF-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GTTAGGTCCAGCATAATTTTC	0.388000													4	243					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75563184	75563184	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr16:75563184C>T	ENST00000336257.3	-	3	2493	c.1099G>A	c.(1099-1101)Gtg>Atg	p.V367M	RP11-77K12.7_ENST00000460606.1_3'UTR|CHST5_ENST00000541075.1_Missense_Mutation_p.V373M	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	367					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						ACCTCCTGCACGCGCAGGATC	0.652000													13	23					0	0	1	0	0
ATF1	466	broad.mit.edu	37	12	51213461	51213461	+	Missense_Mutation	SNP	A	A	C			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr12:51213461A>C	ENST00000262053.3	+	7	737	c.715A>C	c.(715-717)Aaa>Caa	p.K239Q	ATF1_ENST00000539132.1_Missense_Mutation_p.K104Q	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	239					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						AGAATATGTGAAATGCCTGGA	0.313000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								18	29					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27751697	27751697	+	Silent	SNP	C	C	A			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr16:27751697C>A	ENST00000261588.4	+	15	2098	c.2079C>A	c.(2077-2079)tcC>tcA	p.S693S		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	693										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						ACAGTTTGTCCCAGTTAGAGG	0.498000													4	96					1.23904e-05	1.28034e-05	1	1	0
GREB1	9687	broad.mit.edu	37	2	11755408	11755408	+	Missense_Mutation	SNP	G	G	C			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr2:11755408G>C	ENST00000381486.2	+	20	3614	c.3314G>C	c.(3313-3315)gGg>gCg	p.G1105A	GREB1_ENST00000234142.5_Missense_Mutation_p.G1105A|GREB1_ENST00000396123.1_Missense_Mutation_p.G103A	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1105						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GAGGAGCTGGGGACAGAAGGT	0.567000													5	3					0	0	1	0	0
ACAT2	39	broad.mit.edu	37	6	160184039	160184039	+	Silent	SNP	T	T	G			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr6:160184039T>G	ENST00000367048.4	+	2	1904	c.144T>G	c.(142-144)gcT>gcG	p.A48A	ACAT2_ENST00000541436.1_Silent_p.A77A	NM_005891.2	NP_005882.2	Q9BWD1	THIC_HUMAN	acetyl-CoA acetyltransferase 2	48						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(1)	9		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCACTGTGGCTCCGGAAGATG	0.488000													13	78					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71054178	71054178	+	Missense_Mutation	SNP	T	T	C	rs117718337		TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr16:71054178T>C	ENST00000393567.2	-	22	3379	c.3229A>G	c.(3229-3231)Ata>Gta	p.I1077V	HYDIN_ENST00000448089.2_Missense_Mutation_p.I1029V	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1077			I -> V (in dbSNP:rs6416709).					p.I1077V(3)|p.I1029V(3)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATGTTCTTTATGGCCAAGGGC	0.418000													3	32					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153296731	153296731	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chrX:153296731C>T	ENST00000303391.6	-	4	797	c.548G>A	c.(547-549)gGa>gAa	p.G183E	MECP2_ENST00000407218.1_Missense_Mutation_p.E147K|MECP2_ENST00000453960.2_Missense_Mutation_p.G195E	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	183					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTGCCAGTTCCTGGAGCTTT	0.597000													10	45					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887579	12887579	+	Missense_Mutation	SNP	G	G	T	rs2486717	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr1:12887579G>T	ENST00000535591.1	-	3	473	c.278C>A	c.(277-279)aCa>aAa	p.T93K		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	93								p.T93K(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						CTGCACTGGTGTTTTGTTCCT	0.493000													5	271					0.000274275	0.000274275	1	1	0
KYNU	8942	broad.mit.edu	37	2	143715264	143715264	+	Missense_Mutation	SNP	C	C	T	rs147103103		TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr2:143715264C>T	ENST00000264170.4	+	7	820	c.562C>T	c.(562-564)Cgg>Tgg	p.R188W	KYNU_ENST00000409512.1_Missense_Mutation_p.R188W|KYNU_ENST00000375773.2_Missense_Mutation_p.R188W	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	188			R -> Q (in dbSNP:rs2304705).		anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AGAAAGTATGCGGATGATAAA	0.308000													3	49					0	0	1	0	0
RP11-453E17.1	0	broad.mit.edu	37	4	68632418	68632419	+	RNA	INS	-	-	AT	rs59536241	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr4:68632418_68632419insAT	ENST00000500538.2	+	0	1905				RP11-453E17.1_ENST00000502758.1_RNA																							cacacacacacaTATATATAct	0.431													5	2	---	---	---	---					
COL21A1	0	broad.mit.edu	37	6	55966307	55966307	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr6:55966307delG	ENST00000244728.5	-	17	2172	c.1775delC	c.(1774-1776)ctfs	p.P592fs	COL21A1_ENST00000535941.1_Frame_Shift_Del_p.P592fs|COL21A1_ENST00000370819.1_Frame_Shift_Del_p.P589fs	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	592	Collagen-like 2.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CGGAGCACCAGGGGATCCTGC	0.383													2	4	---	---	---	---					
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>AGGAGGggg	p.428_429insRR	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insRR	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													6	5	---	---	---	---					
PLCB3	5331	broad.mit.edu	37	11	64033973	64033980	+	Frame_Shift_Del	DEL	GACGGAGA	GACGGAGA	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr11:64033973_64033980delGACGGAGA	ENST00000540288.1	+	29	3466_3473	c.3363_3370delGACGGAGA	c.(3361-3372)ctttfs	p.LTEI1121fs	PLCB3_ENST00000325234.5_Frame_Shift_Del_p.LTEI1054fs|PLCB3_ENST00000279230.6_Frame_Shift_Del_p.LTEI1121fs	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	1121					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GCAGGGAACTGACGGAGATTAACCGTCG	0.644													13	27	---	---	---	---					
EHBP1L1	254102	broad.mit.edu	37	11	65352540	65352540	+	Frame_Shift_Del	DEL	C	C	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr11:65352540delC	ENST00000309295.4	+	12	3676	c.3411delC	c.(3409-3411)atfs	p.I1137fs		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	1137	CH.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TGTGCCAGATCCGCGCCTTCT	0.716													2	4	---	---	---	---					
REM2	161253	broad.mit.edu	37	14	23354529	23354529	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr14:23354529delT	ENST00000267396.4	+	3	623	c.500delT	c.(499-501)gtfs	p.V167fs	REM2_ENST00000536884.1_Intron	NM_173527.2	NP_775798.2	Q8IYK8	REM2_HUMAN	RAS (RAD and GEM)-like GTP binding 2	167					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|ovary(1)	5	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		ACTCTAGTCGTTTATGACATC	0.507													19	45	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29533281	29533293	+	Frame_Shift_Del	DEL	GATTGATGCTGTG	GATTGATGCTGTG	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr17:29533281_29533293delGATTGATGCTGTG	ENST00000358273.4	+	12	1667_1679	c.1284_1296delGATTGATGCTGTG	c.(1282-1296)aafs	p.KIDAV428fs	NF1_ENST00000356175.3_Frame_Shift_Del_p.KIDAV428fs|NF1_ENST00000431387.4_Frame_Shift_Del_p.KIDAV428fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	428					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGTGGCCTAAGATTGATGCTGTGTATTGTCACT	0.408			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			18	10	---	---	---	---					
APC2	10297	broad.mit.edu	37	19	1465635	1465637	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr19:1465635_1465637delGAC	ENST00000535453.1	+	14	4048_4050	c.2335_2337delGAC	c.(2335-2337)del	p.D782del	APC2_ENST00000238483.4_In_Frame_Del_p.D508del|APC2_ENST00000233607.2_In_Frame_Del_p.D782del|C19orf25_ENST00000588427.1_Intron			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	782					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCTGCTTTGACGACGACGATG	0.719													2	4	---	---	---	---					
ANKRD27	84079	broad.mit.edu	37	19	33116849	33116849	+	Frame_Shift_Del	DEL	G	G	-	rs35109898	byFrequency	TCGA-S7-A7WL-01A-11D-A35I-08	TCGA-S7-A7WL-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	819a5f3c-350e-48ac-a62f-e9ad1b305b51	84a2d7bd-0255-46bc-85d1-cfb47d4e0b0d	g.chr19:33116849delG	ENST00000306065.4	-	17	1718	c.1560delC	c.(1558-1560)gcfs	p.A520fs		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	520					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CTTCCGCGCTGGCCTTGTAGT	0.647													2	4	---	---	---	---					
