Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
S1PR5	53637	broad.mit.edu	37	19	10624929	10624929	+	Silent	SNP	G	G	C			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:10624929G>C	ENST00000439028.3	-	2	884	c.759C>G	c.(757-759)ctC>ctG	p.L253L	S1PR5_ENST00000333430.4_Silent_p.L253L	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	253						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						GCACCACGCTGAGCGTGCGCA	0.736000													3	2					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1629815	1629815	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr20:1629815G>A	ENST00000381580.1	-	2	393	c.214C>T	c.(214-216)Cgc>Tgc	p.R72C	SIRPG_ENST00000344103.4_Missense_Mutation_p.R105C|SIRPG_ENST00000216927.4_Missense_Mutation_p.R105C|SIRPG_ENST00000303415.3_Missense_Mutation_p.R105C|SIRPG_ENST00000381583.2_Missense_Mutation_p.R105C			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	105	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding	p.R105S(1)|p.R105C(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						CTACTGATGCGGATGGAAAAG	0.483000													5	86					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	64					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038778	11038778	+	RNA	SNP	G	G	C			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr21:11038778G>C	ENST00000470054.1	-	0	1425									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAATAGCTGGTTTACCCATG	0.398000													5	179					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													3	47					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476155	42476155	+	Missense_Mutation	SNP	A	A	C			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr17:42476155A>C	ENST00000434000.1	-	9	3338	c.3056T>G	c.(3055-3057)aTc>aGc	p.I1019S	GPATCH8_ENST00000591680.1_Missense_Mutation_p.I1097S			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1097						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CCTTGACTGGATCTTCTCCAG	0.532000													3	38					0	0	1	0	0
IGHV3-43	0	broad.mit.edu	37	14	106926411	106926411	+	RNA	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr14:106926411G>A	ENST00000434710.1	-	0	210																											GGTGAATCCAGAGGCTGCACA	0.562000													10	209					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15508364	15508364	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:15508364G>A	ENST00000397410.4	-	11	1436	c.1372C>T	c.(1372-1374)Cac>Tac	p.H458Y	AKAP8L_ENST00000595465.1_Missense_Mutation_p.H397Y	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	458				H -> Q (in Ref. 2; CAB65092, 3; AAF86048, 4; BAG70140/BAG70283, 6; EAW84475 and 7; AAH00713).		cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						TAGATTTGGTGGATGAGGCCA	0.527000													3	43					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846025	18846025	+	RNA	SNP	G	G	C	rs5993363		TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr22:18846025G>C	ENST00000412938.1	+	0	3383																											GACGTTGAAGGCTGCCTTCAG	0.647000													4	37					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935484	30935484	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:30935484G>A	ENST00000355537.3	+	2	1162	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CGGCGGTGGCGAGCAGTCGGC	0.647000													4	99					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129389998	129389998	+	Missense_Mutation	SNP	C	C	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr3:129389998C>A	ENST00000393238.3	-	4	1026	c.686G>T	c.(685-687)cGc>cTc	p.R229L	TMCC1_ENST00000329333.5_Missense_Mutation_p.R50L|TMCC1_ENST00000426664.2_Missense_Mutation_p.R115L|TMCC1_ENST00000432054.2_5'UTR	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	229						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						AGCCTTTGTGCGCTGAGGGTC	0.532000													4	96					0.00909568	0.00909568	1	1	0
ILF3	3609	broad.mit.edu	37	19	10799870	10799870	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:10799870C>T	ENST00000449870.1	+	20	2896	c.2579C>T	c.(2578-2580)tCg>tTg	p.S860L	ILF3_ENST00000590261.1_Missense_Mutation_p.S856L|ILF3_ENST00000588657.1_Missense_Mutation_p.S860L|ILF3_ENST00000586544.1_3'UTR|ILF3_ENST00000318511.3_Missense_Mutation_p.S856L	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	856	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACTCACAGTCGAACTACAAC	0.632000													12	166					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793658	13793658	+	Silent	SNP	C	C	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr5:13793658C>T	ENST00000265104.4	-	49	8294	c.8190G>A	c.(8188-8190)acG>acA	p.T2730T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2730	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAGAGGGCAACGTGCAATTAA	0.478000									Kartagener syndrome				10	92					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53848849	53848849	+	Missense_Mutation	SNP	G	G	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:53848849G>T	ENST00000458035.1	+	3	223	c.106G>T	c.(106-108)Gtg>Ttg	p.V36L	ZNF845_ENST00000595091.1_Missense_Mutation_p.V36L	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ATACAGGGACGTGATGCTGGA	0.473000													5	121					0.00198382	0.00204995	1	1	0
HSPG2	3339	broad.mit.edu	37	1	22157966	22157966	+	Silent	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr1:22157966G>A	ENST00000374695.3	-	83	11521	c.11442C>T	c.(11440-11442)agC>agT	p.S3814S		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3814	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTATGAAGCCGCTGCTCAGCC	0.642000													4	24					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2968246	2968246	+	Silent	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr7:2968246G>A	ENST00000396946.4	-	13	2143	c.1740C>T	c.(1738-1740)gaC>gaT	p.D580D		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	580					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GATGGGGCGCGTCCTCCTTGT	0.657000			Mis		DLBCL								5	64					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45877227	45877227	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr21:45877227C>T	ENST00000291592.4	+	2	1017	c.700C>T	c.(700-702)Cgg>Tgg	p.R234W		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	234						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GGAGGATGCCCGGAGGCACCT	0.672000													6	39					0	0	1	0	0
C4orf19	55286	broad.mit.edu	37	4	37590515	37590515	+	Missense_Mutation	SNP	T	T	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr4:37590515T>A	ENST00000284437.6	+	2	204	c.26T>A	c.(25-27)aTa>aAa	p.I9K	C4orf19_ENST00000508175.1_Missense_Mutation_p.I9K|C4orf19_ENST00000381980.4_Missense_Mutation_p.I9K	NM_018302.2	NP_060772.2	Q8IY42	CD019_HUMAN	chromosome 4 open reading frame 19	9										large_intestine(1)|lung(3)|skin(3)|stomach(1)|urinary_tract(1)	9						TGTAAAATAATACAAAGGTAA	0.398000													4	32					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75508331	75508331	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr14:75508331G>A	ENST00000355774.2	-	4	3667	c.3452C>T	c.(3451-3453)gCc>gTc	p.A1151V	MLH3_ENST00000556740.1_Missense_Mutation_p.A1151V|MLH3_ENST00000238662.7_Missense_Mutation_p.A1151V|MLH3_ENST00000556257.1_Intron|MLH3_ENST00000555671.1_Intron|MLH3_ENST00000380968.2_Missense_Mutation_p.A97V|MLH3_ENST00000544985.1_Missense_Mutation_p.A146V	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1151					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TGGATAACGGGCAAATACTGG	0.388000								Mismatch excision repair (MMR)					3	30					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202447	248202447	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr1:248202447A>G	ENST00000366479.2	+	1	974	c.878A>G	c.(877-879)aAc>aGc	p.N293S	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AGCCTGAGAAACAAGGAGGTG	0.473000													3	51					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49693162	49693162	+	Missense_Mutation	SNP	T	T	G			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr3:49693162T>G	ENST00000296452.4	+	5	6287	c.6173T>G	c.(6172-6174)aTg>aGg	p.M2058R		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2058					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCGCTTCCCATGCGGCGCTAT	0.602000													4	29					0	0	1	0	0
NDUFS7	374291	broad.mit.edu	37	19	1391008	1391008	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:1391008G>A	ENST00000313408.7	+	5	390	c.367G>A	c.(367-369)Gcc>Acc	p.A123T	NDUFS7_ENST00000414651.2_Missense_Mutation_p.A153T|NDUFS7_ENST00000233627.9_Missense_Mutation_p.A123T|NDUFS7_ENST00000546283.1_Missense_Mutation_p.A123T|NDUFS7_ENST00000540530.1_3'UTR|NDUFS7_ENST00000539480.1_Missense_Mutation_p.A123T			O75251	NDUS7_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	123					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			ovary(1)	1		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)	CATGATCGTGGCCGGCACACT	0.687000													3	23					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46704404	46704404	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr22:46704404C>T	ENST00000454366.1	+	4	538	c.326C>T	c.(325-327)gCt>gTt	p.A109V		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	90					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CACTTACTGGCTTTACACATT	0.572000													4	39					0	0	1	0	0
PHF15	0	broad.mit.edu	37	5	133895558	133895558	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr5:133895558C>T	ENST00000395003.1	+	5	529	c.350C>T	c.(349-351)tCc>tTc	p.S117F	PHF15_ENST00000282605.4_Missense_Mutation_p.S117F|PHF15_ENST00000361895.2_Missense_Mutation_p.S117F|PHF15_ENST00000402835.1_Missense_Mutation_p.S117F	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		117					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCCCAGGCATCCCCGAGCAGC	0.622000													9	13					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46607402	46607402	+	Missense_Mutation	SNP	C	C	G			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr2:46607402C>G	ENST00000263734.3	+	12	2101	c.1591C>G	c.(1591-1593)Ccc>Gcc	p.P531A		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	531	NTAD.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GACACTGGCACCCTATATCCC	0.587000													34	72					0	0	1	0	0
CA11	770	broad.mit.edu	37	19	49142648	49142648	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr19:49142648A>G	ENST00000084798.4	-	7	1388	c.709T>C	c.(709-711)Tat>Cat	p.Y237H	SEC1P_ENST00000430145.2_RNA	NM_001217.3	NP_001208.2	O75493	CAH11_HUMAN	carbonic anhydrase XI	237						extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	14		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		GAGCCCTGATAGGTGATGAAG	0.562000													3	26					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31273075	31273075	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr16:31273075G>A	ENST00000544665.3	+	2	162	c.91G>A	c.(91-93)Gca>Aca	p.A31T	ITGAM_ENST00000287497.8_Missense_Mutation_p.A31T	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	31					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CCAAGAGAACGCAAGGGGCTT	0.517000													5	14					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135752363	135752363	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr6:135752363delG	ENST00000367800.4	-	15	2572	c.2356delC	c.(2356-2358)acfs	p.H786fs	AHI1_ENST00000327035.6_Frame_Shift_Del_p.H786fs|AHI1_ENST00000417892.2_Frame_Shift_Del_p.H140fs|AHI1_ENST00000457866.2_Frame_Shift_Del_p.H786fs	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	786						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		ATAGTCCAGTGGTGCACTGAA	0.303													2	4	---	---	---	---					
SMARCB1	6598	broad.mit.edu	37	22	24176363	24176363	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S7-A7X0-01A-12D-A35I-08	TCGA-S7-A7X0-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac0ac255-1b96-4cad-922d-00e6a1eee43a	189f6578-c5db-4547-8d15-0121e268c8b1	g.chr22:24176363delG	ENST00000344921.6	+	9	1388	c.1181delG	c.(1180-1182)tgfs	p.W394fs	SMARCB1_ENST00000407422.3_Frame_Shift_Del_p.W376fs|SMARCB1_ENST00000407082.3_Frame_Shift_Del_p.W339fs|SMARCB1_ENST00000263121.7_Frame_Shift_Del_p.W385fs			Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	385					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)|p.L266_*386del(1)		bone(4)|central_nervous_system(198)|endometrium(4)|haematopoietic_and_lymphoid_tissue(25)|kidney(3)|large_intestine(5)|liver(2)|lung(5)|meninges(5)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|soft_tissue(194)	458		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				GCCCCGGCCTGGTAACCAGCC	0.662			"""D, N, F, S"""		malignant rhabdoid	malignant rhabdoid							2	4	---	---	---	---					
