Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF845	91664	broad.mit.edu	37	19	53854724	53854724	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr19:53854724A>G	ENST00000458035.1	+	4	913	c.796A>G	c.(796-798)Act>Gct	p.T266A	ZNF845_ENST00000595091.1_Missense_Mutation_p.T266A	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAGATGTCACACTGGCAAGAA	0.388000													14	33					0	0	1	0	0
FAM187B	148109	broad.mit.edu	37	19	35719389	35719389	+	Missense_Mutation	SNP	G	G	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr19:35719389G>C	ENST00000324675.3	-	1	243	c.195C>G	c.(193-195)agC>agG	p.S65R		NM_152481.1	NP_689694.1	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	65						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	9						TATTGGTGAGGCTGGTGAGCC	0.507000													14	39					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													3	48					0	0	1	0	0
KIAA2013	90231	broad.mit.edu	37	1	11985396	11985396	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr1:11985396A>G	ENST00000376572.3	-	1	1084	c.899T>C	c.(898-900)cTc>cCc	p.L300P	KIAA2013_ENST00000376576.3_Missense_Mutation_p.L300P	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	300						integral to membrane				endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGCTTTTGAGCACCTGGGG	0.597000													3	32					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65188460	65188460	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr4:65188460A>G	ENST00000381210.3	-	4	492	c.382T>C	c.(382-384)Tcc>Ccc	p.S128P	TECRL_ENST00000507440.1_Missense_Mutation_p.S128P	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	128					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GTGACAATGGAGGAAGCTGCA	0.323000													4	73					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51190309	51190309	+	Missense_Mutation	SNP	T	T	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr14:51190309T>C	ENST00000245441.5	-	31	6464	c.6274A>G	c.(6274-6276)Act>Gct	p.T2092A	NIN_ENST00000530997.2_Missense_Mutation_p.T2092A|NIN_ENST00000389868.3_3'UTR	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	1939					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CGCTGTTCAGTCACTTCCAGA	0.443000			T	PDGFRB	MPD								4	78					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42045067	42045067	+	Missense_Mutation	SNP	C	C	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr8:42045067C>G	ENST00000220809.4	-	6	644	c.388G>C	c.(388-390)Gac>Cac	p.D130H	PLAT_ENST00000429710.2_Intron|PLAT_ENST00000519510.1_Intron|PLAT_ENST00000352041.3_Missense_Mutation_p.D84H|PLAT_ENST00000429089.2_Missense_Mutation_p.D130H|PLAT_ENST00000270189.6_Missense_Mutation_p.D130H|PLAT_ENST00000524009.1_Intron	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	130	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATGCCCTGGTCCTCGTAGCAC	0.637000													8	19					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4535050	4535050	+	Nonsense_Mutation	SNP	C	C	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr17:4535050C>A	ENST00000570836.1	-	15	1930	c.1834G>T	c.(1834-1836)Gag>Tag	p.E612*	ALOX15_ENST00000574640.1_Nonsense_Mutation_p.E573*|ALOX15_ENST00000293761.3_Nonsense_Mutation_p.E612*|ALOX15_ENST00000545513.1_Nonsense_Mutation_p.E634*			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	612	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GAAAAATACTCCTCCTCATGC	0.577000													4	52					0.00024832	0.00027936	1	1	0
ATG9B	285973	broad.mit.edu	37	7	150713794	150713794	+	Missense_Mutation	SNP	C	C	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr7:150713794C>A	ENST00000377974.2	-	11	2477	c.2402G>T	c.(2401-2403)cGa>cTa	p.R801L	ATG9B_ENST00000444312.1_Missense_Mutation_p.R287L|ATG9B_ENST00000605938.1_3'UTR|ATG9B_ENST00000494791.1_5'UTR			Q674R7	ATG9B_HUMAN	autophagy related 9B	802					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGGGCAATTCGGGAAATGGA	0.662000													3	13					0.004672	0.00485169	1	1	0
FMOD	2331	broad.mit.edu	37	1	203316735	203316735	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr1:203316735G>A	ENST00000354955.4	-	2	1127	c.664C>T	c.(664-666)Ctc>Ttc	p.L222F	FMOD_ENST00000464898.1_5'UTR	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	222					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			AGTGACCGGAGGCCCCTCATG	0.567000													20	72					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42045068	42045068	+	Silent	SNP	C	C	T			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr8:42045068C>T	ENST00000220809.4	-	6	643	c.387G>A	c.(385-387)gaG>gaA	p.E129E	PLAT_ENST00000429710.2_Intron|PLAT_ENST00000519510.1_Intron|PLAT_ENST00000352041.3_Silent_p.E83E|PLAT_ENST00000429089.2_Silent_p.E129E|PLAT_ENST00000270189.6_Silent_p.E129E|PLAT_ENST00000524009.1_Intron	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	129	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGCCCTGGTCCTCGTAGCACG	0.637000													8	19					0	0	1	0	0
TRIM38	10475	broad.mit.edu	37	6	25966899	25966899	+	Missense_Mutation	SNP	A	A	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr6:25966899A>C	ENST00000357085.3	+	3	625	c.149A>C	c.(148-150)aAg>aCg	p.K50T	TRIM38_ENST00000349458.3_Missense_Mutation_p.K50T	NM_006355.3	NP_006346.1	O00635	TRI38_HUMAN	tripartite motif containing 38	50					positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	23						CCAAGCCAAAAGCAACTGAGG	0.507000													3	44					0	0	1	0	0
POLA1	5422	broad.mit.edu	37	X	24761358	24761358	+	Silent	SNP	T	T	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chrX:24761358T>C	ENST00000379068.3	+	23	2521	c.2478T>C	c.(2476-2478)gaT>gaC	p.D826D	POLA1_ENST00000379059.3_Silent_p.D820D			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	820					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	GAGATGAAGATGAAGAAATTG	0.378000													3	37					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2129863	2129863	+	Silent	SNP	T	T	C			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr4:2129863T>C	ENST00000511885.2	-	19	2312	c.1959A>G	c.(1957-1959)gtA>gtG	p.V653V	POLN_ENST00000382865.1_Silent_p.V653V			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	653					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			GAGTAGAAAATACATCATCTC	0.368000								DNA polymerases (catalytic subunits)					6	26					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106976779	106976779	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr10:106976779G>A	ENST00000369701.3	+	19	2860	c.2633G>A	c.(2632-2634)gGc>gAc	p.G878D	SORCS3_ENST00000369699.4_Missense_Mutation_p.G164D	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	878	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATCGAGGACGGCATCAAGCAC	0.517000													3	50					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385626	33385626	+	Missense_Mutation	SNP	G	G	A	rs149760238	by1000genomes	TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr9:33385626G>A	ENST00000537089.1	-	6	806	c.488C>T	c.(487-489)cCa>cTa	p.P163L	AQP7_ENST00000541274.1_Silent_p.P123P|AQP7_ENST00000377425.4_Intron|AQP7_ENST00000539936.1_Missense_Mutation_p.P255L			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		TCAAAGGAATGGGCCTGGGCA	0.622000													4	52					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374978	27374978	+	Missense_Mutation	SNP	G	G	T			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr16:27374978G>T	ENST00000395762.2	+	11	2564	c.2305G>T	c.(2305-2307)Gtt>Ttt	p.V769F	IL4R_ENST00000170630.2_Missense_Mutation_p.V769F|IL4R_ENST00000543915.2_Missense_Mutation_p.V769F|IL4R_ENST00000380922.3_Missense_Mutation_p.V754F	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	769					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						TCCAGGTGGGGTTCCACTGGA	0.637000													13	28					0.00010058	0.000118072	1	1	0
LRP1	4035	broad.mit.edu	37	12	57589943	57589943	+	Silent	SNP	C	C	T	rs139174222	by1000genomes	TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr12:57589943C>T	ENST00000243077.3	+	55	9241	c.8775C>T	c.(8773-8775)aaC>aaT	p.N2925N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2925	LDL-receptor class A 20.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCTCTGCAACGGCCAGGATG	0.637000													16	40					0	0	1	0	0
LPCAT3	10162	broad.mit.edu	37	12	7086308	7086308	+	Nonstop_Mutation	SNP	T	T	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr12:7086308T>G	ENST00000261407.4	-	12	1549	c.1464A>C	c.(1462-1464)taA>taC	p.*488Y	U47924.19_ENST00000564245.1_RNA|LPCAT3_ENST00000535021.1_5'UTR	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	0					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						GGGAAATGGATTATTCCATCT	0.368000													19	45					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22396360	22396360	+	Silent	SNP	A	A	G			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr11:22396360A>G	ENST00000263160.3	+	9	1538	c.1101A>G	c.(1099-1101)ggA>ggG	p.G367G		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	367					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						CTATTGGGGGACAAATTGCAG	0.388000													45	113					0	0	1	0	0
PTPN12	0	broad.mit.edu	37	7	77256458	77256458	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr7:77256458G>A	ENST00000248594.6	+	13	1734	c.1462G>A	c.(1462-1464)Ggt>Agt	p.G488S	PTPN12_ENST00000435495.2_Missense_Mutation_p.G358S|PTPN12_ENST00000415482.2_Missense_Mutation_p.G369S	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	488						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						TCTAAATGTCGGTGATACTTC	0.383000													4	63					0	0	1	0	0
TMEM63A	9725	broad.mit.edu	37	1	226034840	226034842	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr1:226034840_226034842delCTG	ENST00000366835.3	-	24	2593_2595	c.2323_2325delCAG	c.(2323-2325)del	p.Q775del		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	775						integral to membrane|lysosomal membrane	nucleotide binding	p.Q775delQ(1)		breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CACCATAGGTCTGCTGCTGCTGC	0.626													7	126	---	---	---	---					
SDHAP1	0	broad.mit.edu	37	3	195703972	195703973	+	RNA	DEL	AG	AG	-			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr3:195703972_195703973delAG	ENST00000427841.1	-	0	1171_1172					NR_003264.2																						GCGGATCTCCAGAGTCATCCAC	0.574													4	5	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													2	4	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540315	93540316	+	Frame_Shift_Ins	INS	-	-	A			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr15:93540315_93540316insA	ENST00000394196.4	+	29	4792_4793	c.3724_3725insA	c.(3724-3726)aaafs	p.K1242fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.K1242fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1242					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGACCCTGAAGAAAAAAAAAAG	0.347													8	69	---	---	---	---					
TNFAIP1	7126	broad.mit.edu	37	17	26671480	26671492	+	Frame_Shift_Del	DEL	GCCACAAGCCGTA	GCCACAAGCCGTA	-			TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr17:26671480_26671492delGCCACAAGCCGTA	ENST00000226225.2	+	7	1072_1084	c.805_817delGCCACAAGCCGTA	c.(805-819)gcfs	p.ATSRS269fs	TNFAIP1_ENST00000583213.1_3'UTR|TNFAIP1_ENST00000544907.2_Frame_Shift_Del_p.ATSRS165fs	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	269					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CTTGTTGGAGGCCACAAGCCGTAGCCGCAGCCA	0.592													8	21	---	---	---	---					
KRTAP9-9	81870	broad.mit.edu	37	17	39411670	39411671	+	In_Frame_Ins	INS	-	-	ACCTGCTGCAGGACC	rs58108918		TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr17:39411670_39411671insACCTGCTGCAGGACC	ENST00000394008.1	+	1	35_36	c.33_34insACCTGCTGCAGGACC	c.(31-36)cccctg>ccACCTGCTGCAGGACCcctg	p.10_11insPPAAG		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	10						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCTGTCAGCCTACCTGCTGCAG	0.604													7	30	---	---	---	---					
PPM1E	22843	broad.mit.edu	37	17	56833457	56833458	+	In_Frame_Ins	INS	-	-	GAACCC	rs72376816	by1000genomes	TCGA-S7-A7X2-01A-12D-A35I-08	TCGA-S7-A7X2-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c5a75eae-4aa4-4d54-b180-d5dd16e85424	1c55bf22-500e-4742-a4ad-9d0a39aa97fe	g.chr17:56833457_56833458insGAACCC	ENST00000308249.2	+	1	228_229	c.99_100insGAACCC	c.(97-102)ccaacc>ccGAACCCaacc	p.32_33insPN		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	32	11 X 2 AA tandem repeats of P-E.|Glu-rich.|Pro-rich.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			agccggagccggaacccgaacc	0.673													6	4	---	---	---	---					
