Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TUBB8P7	0	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr16:90161578G>A	ENST00000564451.1	+	0	931				TUBB8P7_ENST00000567960.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													3	38					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167031891	167031891	+	Missense_Mutation	SNP	C	C	A			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr3:167031891C>A	ENST00000392766.2	-	16	1628	c.1288G>T	c.(1288-1290)Gat>Tat	p.D430Y	ZBBX_ENST00000307529.5_Missense_Mutation_p.D430Y|ZBBX_ENST00000455345.2_Missense_Mutation_p.D430Y|ZBBX_ENST00000392767.2_Missense_Mutation_p.D430Y|ZBBX_ENST00000392764.1_Missense_Mutation_p.D401Y	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	430						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TTCTGACAATCATGAAAAGCA	0.299000													12	58					0.00136819	0.00145941	1	1	0
GPRASP1	9737	broad.mit.edu	37	X	101911811	101911811	+	Silent	SNP	G	G	C			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chrX:101911811G>C	ENST00000537097.1	+	6	3783	c.2970G>C	c.(2968-2970)ggG>ggC	p.G990G	GPRASP1_ENST00000361600.5_Silent_p.G990G|GPRASP1_ENST00000415986.1_Silent_p.G990G|GPRASP1_ENST00000444152.1_Silent_p.G990G|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	990	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GCAACTGTGGGTCCAGGACAT	0.512000													4	64					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													3	51					0	0	1	0	0
PCDHGA7	0	broad.mit.edu	37	5	140763352	140763352	+	Missense_Mutation	SNP	T	T	C			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr5:140763352T>C	ENST00000518325.1	+	1	886	c.886T>C	c.(886-888)Tcg>Ccg	p.S296P	PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCTGAACTCGCTTACAGG	0.418000													7	23					0	0	1	0	0
SYPL1	0	broad.mit.edu	37	7	105738244	105738244	+	Silent	SNP	T	T	C			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr7:105738244T>C	ENST00000455385.2	-	3	416	c.294A>G	c.(292-294)caA>caG	p.Q98Q	SYPL1_ENST00000470347.1_Silent_p.Q98Q|SYPL1_ENST00000011473.2_Silent_p.Q116Q	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	116	MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						TAACATAGAATTGTGCAGAAG	0.423000													9	48					0	0	1	0	0
ID2	3398	broad.mit.edu	37	2	8822538	8822538	+	Silent	SNP	G	G	A			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr2:8822538G>A	ENST00000234091.4	+	3	1103	c.243G>A	c.(241-243)tcG>tcA	p.S81S	ID2_ENST00000331129.3_Silent_p.S81S|ID2_ENST00000396290.1_Silent_p.S81S			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	81					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding	p.S81S(1)		breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCCTGGACTCGCATCCCACTA	0.582000													3	54					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32956104	32956104	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr17:32956104C>T	ENST00000321639.5	+	5	1277	c.949C>T	c.(949-951)Cgg>Tgg	p.R317W		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	317						integral to membrane		p.R317W(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCAGTCAAGCGGAGGATCAT	0.612000													9	69					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200878465	200878465	+	Missense_Mutation	SNP	G	G	A			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr1:200878465G>A	ENST00000367342.4	+	8	1354	c.1154G>A	c.(1153-1155)cGc>cAc	p.R385H	C1orf106_ENST00000413687.2_Missense_Mutation_p.R300H	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	385										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						TGGCAGGGCCGCACCAGTGCC	0.642000													3	22					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26428143	26428143	+	RNA	SNP	G	G	C			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr6:26428143G>C	ENST00000466808.2	+	0	1112																											GATCCTGCCTGTTATCATGAT	0.428000													3	103					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9887074	9887074	+	Missense_Mutation	SNP	G	G	A			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr18:9887074G>A	ENST00000306084.6	+	2	797	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000357775.4_Missense_Mutation_p.E133K	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	200	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GTCCTCAGAAGAAGCCATCCA	0.577000													4	90					0	0	1	0	0
SPIC	121599	broad.mit.edu	37	12	101880259	101880259	+	Missense_Mutation	SNP	C	C	A			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr12:101880259C>A	ENST00000551346.1	+	6	616	c.457C>A	c.(457-459)Ctt>Att	p.L153I	SPIC_ENST00000299272.5_Missense_Mutation_p.L153I			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	153						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						ACTTGCCGAGCTTTGGGGGAA	0.418000													4	43					1	1	1	1	0
ITGBL1	9358	broad.mit.edu	37	13	102359178	102359178	+	Missense_Mutation	SNP	G	G	A	rs149770736		TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr13:102359178G>A	ENST00000376180.3	+	9	1424	c.1205G>A	c.(1204-1206)cGg>cAg	p.R402Q	ITGBL1_ENST00000545560.2_Missense_Mutation_p.R261Q|ITGBL1_ENST00000376162.3_Missense_Mutation_p.R309Q	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	402	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAACATCCGCGGAAGTGTAAC	0.517000													4	148					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31110764	31110766	+	In_Frame_Del	DEL	CTG	CTG	-	rs140560656		TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr6:31110764_31110766delCTG	ENST00000396268.3	-	17	2653_2655	c.2465_2467delCAG	c.(2464-2469)gtg>g	p.AV822del	CCHCR1_ENST00000451521.2_In_Frame_Del_p.AV786del|CCHCR1_ENST00000396263.2_In_Frame_Del_p.AV680del|CCHCR1_ENST00000376266.5_In_Frame_Del_p.AV733del	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	733					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CTGGTGGGCACTGCTGCTGCTAC	0.532													7	382	---	---	---	---					
RP11-248G5.8	0	broad.mit.edu	37	13	52857402	52857402	+	RNA	DEL	A	A	-			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr13:52857402delA	ENST00000451298.1	-	0	303				RP11-64P12.8_ENST00000606031.1_RNA																							ACTTAACGTCAAAAAAAATGT	0.289													2	4	---	---	---	---					
DOC2A	8448	broad.mit.edu	37	16	30020586	30020586	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SP-A6QH-01A-21D-A35I-08	TCGA-SP-A6QH-11A-12D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06c3f43d-8457-4be9-95fd-b7c86e5ad223	b9e1eb7d-7b59-483a-a035-d7b571ca085e	g.chr16:30020586delG	ENST00000350119.4	-	4	544	c.354delC	c.(352-354)ccfs	p.P118fs	DOC2A_ENST00000564944.1_Frame_Shift_Del_p.P118fs|DOC2A_ENST00000564979.1_Frame_Shift_Del_p.P118fs	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	118	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						TGAAATCCATGGGCTTGAGGC	0.647													2	4	---	---	---	---					
