Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	73					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95376476	95376476	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr4:95376476C>T	ENST00000317968.4	+	2	173	c.37C>T	c.(37-39)Cct>Tct	p.P13S	PDLIM5_ENST00000450793.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000508216.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000512274.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000542407.1_5'UTR|PDLIM5_ENST00000318007.5_Missense_Mutation_p.P13S|PDLIM5_ENST00000538141.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000504489.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000359265.4_Missense_Mutation_p.P13S|PDLIM5_ENST00000380180.3_Missense_Mutation_p.P13S|PDLIM5_ENST00000514743.1_Missense_Mutation_p.P13S|PDLIM5_ENST00000437932.1_Missense_Mutation_p.P13S	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	13	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		TGGCCCAGCTCCTTGGGGTTT	0.408000													6	12					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			30	36					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	37					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21746483	21746483	+	Missense_Mutation	SNP	T	T	G			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr13:21746483T>G	ENST00000314759.5	-	3	450	c.326A>C	c.(325-327)aAt>aCt	p.N109T	SKA3_ENST00000400018.3_Missense_Mutation_p.N109T	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	109					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CAAACCTGAATTTTTCTTGAC	0.303000													32	46					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53602646	53602646	+	Missense_Mutation	SNP	C	C	A			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chrX:53602646C>A	ENST00000342160.3	-	44	6444	c.5987G>T	c.(5986-5988)cGt>cTt	p.R1996L	HUWE1_ENST00000262854.6_Missense_Mutation_p.R1996L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1996					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ACTGCTCTGACGCGTAAGTGA	0.443000													24	34					2.39556e-15	2.59519e-15	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62294307	62294307	+	Missense_Mutation	SNP	G	G	A	rs151063380		TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr11:62294307G>A	ENST00000378024.4	-	5	7856	c.7582C>T	c.(7582-7584)Cct>Tct	p.P2528S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2528					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCTACTTCAGGGCCCTCTGCT	0.507000													7	180					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													4	35					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								5	48					0	0	1	0	0
TOR3A	64222	broad.mit.edu	37	1	179064186	179064186	+	Missense_Mutation	SNP	G	G	A			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr1:179064186G>A	ENST00000367627.3	+	6	1779	c.1027G>A	c.(1027-1029)Gtg>Atg	p.V343M	TOR3A_ENST00000352445.6_Intron	NM_022371.3	NP_071766.2	Q9H497	TOR3A_HUMAN	torsin family 3, member A	343					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|urinary_tract(1)	13						GTACCGTCACGTGAGGCTGTG	0.507000													4	101					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723377	48723377	+	Missense_Mutation	SNP	G	G	T			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr12:48723377G>T	ENST00000335017.1	+	1	615	c.303G>T	c.(301-303)agG>agT	p.R101S		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	101					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						AAGCGCCCAGGGGGCAGGCCA	0.672000													8	7					0.000274275	0.000274275	1	1	0
TTN	7273	broad.mit.edu	37	2	179650740	179650740	+	Silent	SNP	G	G	A			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr2:179650740G>A	ENST00000589042.1	-	14	2429	c.2205C>T	c.(2203-2205)taC>taT	p.Y735Y	TTN_ENST00000359218.5_Silent_p.Y689Y|TTN_ENST00000342992.6_Silent_p.Y735Y|TTN_ENST00000342175.6_Silent_p.Y689Y|TTN_ENST00000591111.1_Silent_p.Y735Y|TTN_ENST00000360870.5_Silent_p.Y735Y|TTN_ENST00000460472.2_Silent_p.Y689Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	735							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTATATCCGTACTCCAAAG	0.537000													3	54					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42231224	42231224	+	Silent	SNP	T	T	G			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr19:42231224T>G	ENST00000221992.6	+	9	2211	c.2097T>G	c.(2095-2097)gtT>gtG	p.V699V	CEACAM5_ENST00000398599.4_Silent_p.V698V|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Silent_p.V699V	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	699						anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TGGTTGGGGTTGCTCTGATAT	0.498000													12	218					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129520747	129520747	+	Missense_Mutation	SNP	A	A	G			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr5:129520747A>G	ENST00000305031.4	+	3	2270	c.1912A>G	c.(1912-1914)Atg>Gtg	p.M638V		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	638						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CTTGAGATTCATGGAGAACTT	0.398000													9	71					0	0	1	0	0
TRAV3	0	broad.mit.edu	37	14	22192478	22192478	+	RNA	SNP	G	G	A			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr14:22192478G>A	ENST00000390425.2	+	0	429																											CTTTGAAGCTGAATTTAACAA	0.463000													19	32					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161519378	161519378	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr6:161519378C>T	ENST00000392142.4	+	17	3741	c.3593C>T	c.(3592-3594)gCt>gTt	p.A1198V	MAP3K4_ENST00000366919.2_Intron|MAP3K4_ENST00000366920.2_Missense_Mutation_p.A1194V|MAP3K4_ENST00000348824.7_Intron	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1198	Poly-Ala.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		gctgctgctgctgctgttgct	0.597000													5	137					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49062200	49062200	+	Missense_Mutation	SNP	G	G	A	rs2856748		TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chrX:49062200G>A	ENST00000376265.2	-	47	5640	c.5579C>T	c.(5578-5580)gCg>gTg	p.A1860V	CACNA1F_ENST00000376251.1_Missense_Mutation_p.A1795V|CACNA1F_ENST00000323022.5_Missense_Mutation_p.A1849V	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1860				A -> G (in Ref. 4; AAB92359).	axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity	p.A1860V(1)		autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CCCCTCCCCCGCTGCGCCCTC	0.652000													7	7					0	0	1	0	0
RP11-182I10.3	0	broad.mit.edu	37	1	65451792	65451793	+	RNA	INS	-	-	T	rs113756498		TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr1:65451792_65451793insT	ENST00000447748.1	-	0	1775																											CAATCTAATTGttttttttttt	0.490													2	4	---	---	---	---					
ARNT	0	broad.mit.edu	37	1	150814926	150814930	+	Frame_Shift_Del	DEL	GCTCT	GCTCT	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr1:150814926_150814930delGCTCT	ENST00000358595.5	-	5	442_446	c.242_246delAGAGC	c.(241-246)cfs	p.QS81fs	ARNT_ENST00000505755.1_Intron|ARNT_ENST00000354396.2_Frame_Shift_Del_p.QS81fs|ARNT_ENST00000515192.1_Frame_Shift_Del_p.QS72fs	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	81					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATCCGCAGAGCTCTGCTCATCATC	0.390			T	ETV6	AML								37	84	---	---	---	---					
FLNB	2317	broad.mit.edu	37	3	58104625	58104625	+	Frame_Shift_Del	DEL	C	C	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr3:58104625delC	ENST00000357272.4	+	19	2937	c.2772delC	c.(2770-2772)tafs	p.Y924fs	FLNB_ENST00000429972.2_Frame_Shift_Del_p.Y924fs|FLNB_ENST00000295956.4_Frame_Shift_Del_p.Y924fs|FLNB_ENST00000419752.2_Frame_Shift_Del_p.Y755fs|FLNB_ENST00000493452.1_Frame_Shift_Del_p.Y755fs|FLNB_ENST00000490882.1_Frame_Shift_Del_p.Y924fs|FLNB_ENST00000358537.3_Frame_Shift_Del_p.Y924fs|FLNB_ENST00000348383.5_Frame_Shift_Del_p.Y924fs			O75369	FLNB_HUMAN	filamin B, beta	924				Y -> H (in Ref. 6; CAE46040).	actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGGTGACTTACGGTGGCGATC	0.473													26	51	---	---	---	---					
SOBP	55084	broad.mit.edu	37	6	107956280	107956282	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr6:107956280_107956282delGCC	ENST00000317357.5	+	6	2891_2893	c.2232_2234delGCC	c.(2230-2235)cag>ca	p.QP744del	SOBP_ENST00000494935.1_3'UTR	NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	744	Pro-rich.						metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CTCCCGAGCAgccgccgccgccg	0.749													2	4	---	---	---	---					
RP11-1220K2.2	0	broad.mit.edu	37	7	141871942	141871942	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr7:141871942delG	ENST00000477922.3	+	29	3450	c.3396delG	c.(3394-3396)ctfs	p.L1132fs																	endometrium(1)|lung(5)	6						ACATGGCACTGGAGGAGGATG	0.473													2	4	---	---	---	---					
HNRNPKP3	0	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													2	4	---	---	---	---					
RP11-248G5.8	0	broad.mit.edu	37	13	52768405	52768405	+	RNA	DEL	G	G	-			TCGA-SP-A6QJ-01A-11D-A35I-08	TCGA-SP-A6QJ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75f94b37-99fd-4a05-88af-89a284b000b5	c80d68e4-25c6-4f27-bbac-f615d0e4ab59	g.chr13:52768405delG	ENST00000451298.1	-	0	1229				RP11-64P12.8_ENST00000606031.1_RNA																							GTTCCATGCCGAGCAGCGAGT	0.587													2	4	---	---	---	---					
