Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RET	5979	broad.mit.edu	37	10	43609948	43609948	+	Missense_Mutation	SNP	T	T	C	rs75076352		TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr10:43609948T>C	ENST00000355710.3	+	11	2132	c.1900T>C	c.(1900-1902)Tgc>Cgc	p.C634R	RET_ENST00000340058.5_Missense_Mutation_p.C634R	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	634			C -> CHELC (in MEN2A).|C -> F (in MEN2A and pheochromocytoma).|C -> G (in MEN2A and pheochromocytoma).|C -> R (in MEN2A, pheochromocytoma and MTC; familial form; also found as somatic mutation in a sporadic thyroid carcinoma).|C -> S (in MEN2A, pheochromocytoma and MTC; familial form).|C -> W (in MEN2A, pheochromocytoma and MTC; familial form).|C -> Y (in MEN2A, pheochromocytoma and MTC; familial form).|CR -> WG (in MEN2A).|ELC -> DVR (in MEN2A).		homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.E632_T636>SS(14)|p.C634R(8)|p.D631_I638>A(1)|p.E632_C634>L(1)|p.E632_A640>VRP(1)	CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CGACGAGCTGTGCCGCACGGT	0.622000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				11	27					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187527280	187527280	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr4:187527280C>T	ENST00000441802.2	-	17	10503	c.10294G>A	c.(10294-10296)Gat>Aat	p.D3432N		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3432	Cadherin 31.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCATTGACATCGGACACATCG	0.507000										HNSCC(5;0.00058)			9	96					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616485	92616485	+	Missense_Mutation	SNP	A	A	C			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr11:92616485A>C	ENST00000298047.6	+	23	12880	c.12863A>C	c.(12862-12864)aAc>aCc	p.N4288T	FAT3_ENST00000533797.1_Missense_Mutation_p.N623T|FAT3_ENST00000489716.1_3'UTR|FAT3_ENST00000525166.1_Missense_Mutation_p.N4138T|FAT3_ENST00000409404.2_Missense_Mutation_p.N4288T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4288					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.N4288T(4)|p.N863T(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGCCCCCAACCTCCCCGCC	0.657000										TCGA Ovarian(4;0.039)			10	47					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84224883	84224883	+	Missense_Mutation	SNP	A	A	G			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr16:84224883A>G	ENST00000268624.3	+	1	140	c.47A>G	c.(46-48)aAg>aGg	p.K16R	ADAD2_ENST00000567413.1_3'UTR|ADAD2_ENST00000315906.5_Missense_Mutation_p.K16R	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	16					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						AGTCGTAGGAAGCCCCGCCTG	0.716000													6	6					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53732212	53732212	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr1:53732212C>T	ENST00000306052.6	-	9	1461	c.1360G>A	c.(1360-1362)Gca>Aca	p.A454T	LRP8_ENST00000465675.1_Missense_Mutation_p.A7T|LRP8_ENST00000371454.2_Missense_Mutation_p.A454T|LRP8_ENST00000347547.2_Missense_Mutation_p.A284T|LRP8_ENST00000354412.3_Missense_Mutation_p.A325T	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	454					cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						ACATCTAGTGCCACGACATTC	0.542000													3	43					0	0	1	0	0
KCTD5	54442	broad.mit.edu	37	16	2732747	2732747	+	Silent	SNP	G	G	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr16:2732747G>A	ENST00000301738.4	+	1	272	c.198G>A	c.(196-198)ccG>ccA	p.P66P	KCTD5_ENST00000564195.1_Silent_p.P66P	NM_018992.3	NP_061865.1	Q9NXV2	KCTD5_HUMAN	potassium channel tetramerization domain containing 5	66	BTB.				interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2						GCCGGGACCCGAAATCCTTCC	0.687000													13	30					0	0	1	0	0
IL13RA1	3597	broad.mit.edu	37	X	117892071	117892071	+	Missense_Mutation	SNP	A	A	G			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chrX:117892071A>G	ENST00000371666.3	+	5	609	c.542A>G	c.(541-543)cAa>cGa	p.Q181R	IL13RA1_ENST00000371642.1_Missense_Mutation_p.Q181R|IL13RA1_ENST00000481868.1_3'UTR	NM_001560.2	NP_001551.1	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1	181						interleukin-13 receptor complex	cytokine receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	12						AGAGAAGGCCAATACTTTGGT	0.348000													32	119					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113242030	113242030	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr9:113242030C>T	ENST00000401783.2	-	13	2708	c.2372G>A	c.(2371-2373)cGt>cAt	p.R791H	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.R791H|SVEP1_ENST00000374461.1_Missense_Mutation_p.R768H|SVEP1_ENST00000374469.1_Missense_Mutation_p.R768H	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	791					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GTTTGCAAAACGTTTTTCTAG	0.343000													49	132					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52456806	52456806	+	Silent	SNP	C	C	T			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr3:52456806C>T	ENST00000327906.3	+	10	1488	c.828C>T	c.(826-828)tgC>tgT	p.C276C	PHF7_ENST00000347025.2_Silent_p.C237C|PHF7_ENST00000478707.1_Silent_p.C276C	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	276						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		GTGCTACATGCGGATCCCACG	0.532000													4	119					0	0	1	0	0
TRAV8-2	0	broad.mit.edu	37	14	22315304	22315304	+	RNA	SNP	G	G	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr14:22315304G>A	ENST00000390434.3	+	0	467																											GGCATCAACGGTTTTGAGGCT	0.498000											OREG0022570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	108					0	0	1	0	0
BBS7	0	broad.mit.edu	37	4	122774228	122774228	+	Silent	SNP	A	A	G			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr4:122774228A>G	ENST00000264499.4	-	8	915	c.732T>C	c.(730-732)atT>atC	p.I244I	BBS7_ENST00000506636.1_Silent_p.I244I	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	244					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						CAAAGCTGTCAATACACAAAA	0.333000									Bardet-Biedl syndrome				14	44					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153134383	153134383	+	Missense_Mutation	SNP	G	G	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chrX:153134383G>A	ENST00000370060.1	-	12	1481	c.1292C>T	c.(1291-1293)gCg>gTg	p.A431V	L1CAM_ENST00000370055.1_Missense_Mutation_p.A426V|L1CAM_ENST00000370057.3_Missense_Mutation_p.A431V|L1CAM_ENST00000361981.3_Missense_Mutation_p.A426V|L1CAM_ENST00000538883.1_Missense_Mutation_p.A433V|L1CAM_ENST00000361699.4_Missense_Mutation_p.A431V|L1CAM_ENST00000543994.1_Missense_Mutation_p.A433V	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	431	Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGATTGTCCGCAGTCAGGAT	0.617000													4	99					0	0	1	0	0
GAGE2A	729447	broad.mit.edu	37	X	49355893	49355893	+	Missense_Mutation	SNP	C	C	G	rs147803166	by1000genomes	TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chrX:49355893C>G	ENST00000362097.1	+	3	258	c.175C>G	c.(175-177)Cag>Gag	p.Q59E		NM_001127212.1	NP_001120684.1			G antigen 2A									p.Q59E(8)		endometrium(4)	4	Ovarian(276;0.236)					TCAGGAGGGACAGGATGAGGG	0.562000													7	537					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43607567	43607567	+	Missense_Mutation	SNP	T	T	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr10:43607567T>A	ENST00000355710.3	+	8	1775	c.1543T>A	c.(1543-1545)Tgc>Agc	p.C515S	RET_ENST00000340058.5_Missense_Mutation_p.C515S	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	515					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GGAGGCGGGCTGCCCCCTGTC	0.667000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	11					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	25					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144863392	144863392	+	Missense_Mutation	SNP	T	T	G			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr1:144863392T>G	ENST00000369359.4	-	40	6457	c.6419A>C	c.(6418-6420)cAg>cCg	p.Q2140P	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.Q2004P|RP4-791M13.4_ENST00000532137.1_RNA|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.Q2004P|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.Q2089P|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.Q1898P			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2004					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCAAAGAGCTGCTGTTTCTC	0.532000			T	PDGFRB	MPD								8	166					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114782724	114782724	+	Missense_Mutation	SNP	C	C	T			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr13:114782724C>T	ENST00000334062.7	-	12	1316	c.1195G>A	c.(1195-1197)Gcc>Acc	p.A399T	RASA3_ENST00000389544.4_Missense_Mutation_p.A367T	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	399	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TCCTCGATGGCGGGCTTCAGG	0.622000											OREG0022538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	126					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126210125	126210125	+	Missense_Mutation	SNP	G	G	C			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr6:126210125G>C	ENST00000368357.3	+	10	1277	c.925G>C	c.(925-927)Gaa>Caa	p.E309Q	NCOA7_ENST00000392477.2_Missense_Mutation_p.E309Q|NCOA7_ENST00000229634.9_Missense_Mutation_p.E194Q	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	309					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CAGGCCTGGAGAATGGGAAGA	0.408000													4	180					0	0	1	0	0
IGHV4-61	0	broad.mit.edu	37	14	107095454	107095454	+	RNA	SNP	A	A	G			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr14:107095454A>G	ENST00000390630.2	-	0	147																											AGAGACCCACAGTGAGCCCTG	0.617000													4	30					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51534095	51534095	+	Missense_Mutation	SNP	G	G	A			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr19:51534095G>A	ENST00000529888.1	-	4	355	c.280C>T	c.(280-282)Cac>Tac	p.H94Y	KLK12_ENST00000319590.4_Silent_p.I180I|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000250351.4_Silent_p.I180I|KLK12_ENST00000250352.11_Silent_p.I70I|KLK12_ENST00000525263.1_Silent_p.I180I	NM_145895.1	NP_665902.1	Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	0	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		TGTTGCTCGTGATTCTCCCGG	0.622000													61	128					0	0	1	0	0
RP11-13J8.1	0	broad.mit.edu	37	2	201967217	201967218	+	RNA	DEL	AG	AG	-			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr2:201967217_201967218delAG	ENST00000448256.1	+	0	627_628																											aaaaaaaaaaagaaTTTGTTCT	0.460													5	8	---	---	---	---					
CASP8AP2	9994	broad.mit.edu	37	6	90556398	90556398	+	RNA	DEL	T	T	-			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr6:90556398delT	ENST00000551025.1	+	0	1492							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TCTAAtttccttttttttttt	0.418													3	4	---	---	---	---					
ZNF484	83744	broad.mit.edu	37	9	95609713	95609713	+	Frame_Shift_Del	DEL	T	T	-			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr9:95609713delT	ENST00000395505.2	-	3	1340	c.1248delA	c.(1246-1248)aafs	p.K416fs	ZNF484_ENST00000375495.3_Frame_Shift_Del_p.K452fs|ZNF484_ENST00000395506.3_Frame_Shift_Del_p.K454fs|ZNF484_ENST00000332591.6_Frame_Shift_Del_p.K416fs|ANKRD19P_ENST00000473204.1_RNA	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						GGAGTTGTGATTTTTTAATAA	0.383													19	83	---	---	---	---					
MYO15A	51168	broad.mit.edu	37	17	18023292	18023293	+	Frame_Shift_Ins	INS	-	-	C			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr17:18023292_18023293insC	ENST00000205890.5	+	2	1516_1517	c.1178_1179insC	c.(1177-1179)tccfs	p.S393fs		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	393	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GAGGCCATCTACCCCCCCGAGG	0.619													7	141	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-SP-A6QK-01A-11D-A35I-08	TCGA-SP-A6QK-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8faaac2-d88c-41c9-aa3f-c073a574a4c8	072a0cc2-5721-4b9a-a19c-dbc4f36876fd	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													3	6	---	---	---	---					
