Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANGEL1	23357	broad.mit.edu	37	14	77275462	77275462	+	Missense_Mutation	SNP	T	T	C			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr14:77275462T>C	ENST00000251089.2	-	2	701	c.589A>G	c.(589-591)Atc>Gtc	p.I197V		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	197										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		AAGGGCCAGATGGAAGCCTCT	0.612000													5	23					0	0	1	0	0
CD82	3732	broad.mit.edu	37	11	44640634	44640634	+	Silent	SNP	G	G	A			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr11:44640634G>A	ENST00000227155.4	+	10	1010	c.762G>A	c.(760-762)cgG>cgA	p.R254R	CD82_ENST00000530931.1_3'UTR|CD82_ENST00000342935.3_Silent_p.R229R	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	254						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						GCTTGTGCCGGCACGTCCATT	0.652000													4	38					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													3	25					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869931	97869931	+	Missense_Mutation	SNP	A	A	T	rs76309140		TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr2:97869931A>T	ENST00000420699.2	+	50	3236	c.2992A>T	c.(2992-2994)Aca>Tca	p.T998S	ANKRD36_ENST00000461153.2_Missense_Mutation_p.T998S	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	998								p.T998S(13)		endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CATTCAGGCTACAAGTGATGA	0.289000													3	21					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021126	73021126	+	Silent	SNP	C	C	T	rs145219831		TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr11:73021126C>T	ENST00000263674.3	+	1	1793	c.1443C>T	c.(1441-1443)gaC>gaT	p.D481D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	481					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TGCGCTCAGACCTTTCAGAGC	0.577000													4	22					0	0	1	0	0
SOCS5	0	broad.mit.edu	37	2	46986916	46986916	+	Missense_Mutation	SNP	C	C	A			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr2:46986916C>A	ENST00000306503.5	+	2	1419	c.1247C>A	c.(1246-1248)tCt>tAt	p.S416Y	SOCS5_ENST00000394861.2_Missense_Mutation_p.S416Y	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	416	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TACCTCTTCTCTGTGAGCTTC	0.527000													24	67					1.55469e-16	1.69603e-16	1	1	0
PML	5371	broad.mit.edu	37	15	74336715	74336715	+	Missense_Mutation	SNP	C	C	G			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr15:74336715C>G	ENST00000565898.1	+	8	1955	c.1871C>G	c.(1870-1872)cCt>cGt	p.P624R	PML_ENST00000268058.3_Missense_Mutation_p.P672R			P29590	PML_HUMAN	promyelocytic leukemia	672					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						ATGCGCCGCCCTATCTTGGCC	0.602000			T	"""RARA, PAX5"""	"""APL, ALL"""								23	53					0	0	1	0	0
HP	3240	broad.mit.edu	37	16	72094218	72094218	+	Missense_Mutation	SNP	T	T	C			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr16:72094218T>C	ENST00000355906.5	+	7	708	c.650T>C	c.(649-651)aTt>aCt	p.I217T	HP_ENST00000565574.1_Missense_Mutation_p.I158T|HPR_ENST00000356967.5_Intron|HP_ENST00000562526.1_Intron|HP_ENST00000398131.2_Missense_Mutation_p.I158T|HP_ENST00000570083.1_Missense_Mutation_p.I158T	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	217	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		GCGAAAGACATTGCCCCTACT	0.453000													7	39					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77275462	77275462	+	Missense_Mutation	SNP	T	T	C			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr14:77275462T>C	ENST00000251089.2	-	2	701	c.589A>G	c.(589-591)Atc>Gtc	p.I197V		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	197										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		AAGGGCCAGATGGAAGCCTCT	0.612000													5	23					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	76					0	0	1	0	0
CD82	3732	broad.mit.edu	37	11	44640634	44640634	+	Silent	SNP	G	G	A			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr11:44640634G>A	ENST00000227155.4	+	10	1010	c.762G>A	c.(760-762)cgG>cgA	p.R254R	CD82_ENST00000530931.1_3'UTR|CD82_ENST00000342935.3_Silent_p.R229R	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	254						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						GCTTGTGCCGGCACGTCCATT	0.652000													4	38					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000509479.2_Silent_p.Q497Q|MAML3_ENST00000327122.5_Silent_p.Q341Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													3	25					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021126	73021126	+	Silent	SNP	C	C	T	rs145219831		TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr11:73021126C>T	ENST00000263674.3	+	1	1793	c.1443C>T	c.(1441-1443)gaC>gaT	p.D481D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	481					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TGCGCTCAGACCTTTCAGAGC	0.577000													4	22					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74336715	74336715	+	Missense_Mutation	SNP	C	C	G			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr15:74336715C>G	ENST00000565898.1	+	8	1955	c.1871C>G	c.(1870-1872)cCt>cGt	p.P624R	PML_ENST00000268058.3_Missense_Mutation_p.P672R			P29590	PML_HUMAN	promyelocytic leukemia	672					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						ATGCGCCGCCCTATCTTGGCC	0.602000			T	"""RARA, PAX5"""	"""APL, ALL"""								23	53					0	0	1	0	0
SOCS5	0	broad.mit.edu	37	2	46986916	46986916	+	Missense_Mutation	SNP	C	C	A			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr2:46986916C>A	ENST00000306503.5	+	2	1419	c.1247C>A	c.(1246-1248)tCt>tAt	p.S416Y	SOCS5_ENST00000394861.2_Missense_Mutation_p.S416Y	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	416	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TACCTCTTCTCTGTGAGCTTC	0.527000													24	67					1.55469e-16	1.65186e-16	1	1	0
HP	3240	broad.mit.edu	37	16	72094218	72094218	+	Missense_Mutation	SNP	T	T	C			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr16:72094218T>C	ENST00000355906.5	+	7	708	c.650T>C	c.(649-651)aTt>aCt	p.I217T	HP_ENST00000565574.1_Missense_Mutation_p.I158T|HP_ENST00000398131.2_Missense_Mutation_p.I158T|HP_ENST00000562526.1_Intron|HP_ENST00000570083.1_Missense_Mutation_p.I158T|HPR_ENST00000356967.5_Intron	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	217	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		GCGAAAGACATTGCCCCTACT	0.453000													7	39					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200881013	200881013	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr1:200881013delG	ENST00000367342.4	+	9	1847	c.1647delG	c.(1645-1647)gafs	p.E549fs	C1orf106_ENST00000413687.2_Frame_Shift_Del_p.E464fs	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	549										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						ACGAGGAGGAGGGCACTCCCC	0.741													2	4	---	---	---	---					
ANK1	286	broad.mit.edu	37	8	41582014	41582014	+	Frame_Shift_Del	DEL	A	A	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr8:41582014delA	ENST00000396942.1	-	7	754	c.671delT	c.(670-672)tgfs	p.L226fs	ANK1_ENST00000396945.1_Frame_Shift_Del_p.L226fs|ANK1_ENST00000352337.4_Frame_Shift_Del_p.L226fs|ANK1_ENST00000289734.7_Frame_Shift_Del_p.L226fs|ANK1_ENST00000379758.2_Frame_Shift_Del_p.L226fs|ANK1_ENST00000347528.4_Frame_Shift_Del_p.L226fs|ANK1_ENST00000265709.8_Frame_Shift_Del_p.L259fs			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	226	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTTGAGGAGCAACTGGGCCAC	0.587													2	4	---	---	---	---					
MAP2K1	5604	broad.mit.edu	37	15	66727443	66727457	+	In_Frame_Del	DEL	TCTTACCCAGAAGCA	TCTTACCCAGAAGCA	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr15:66727443_66727457delTCTTACCCAGAAGCA	ENST00000307102.5	+	2	690_704	c.159_173delTCTTACCCAGAAGCA	c.(157-174)ttg>tt	p.FLTQKQ53del		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	53			F -> S (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K57N(3)|p.K57T(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						TTGAGGCCTTTCTTACCCAGAAGCAGAAGGTGGGA	0.553													15	96	---	---	---	---					
CCDC105	126402	broad.mit.edu	37	19	15121690	15121691	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	1c3306d6-8c60-4750-a3df-72c2d355a6a4	g.chr19:15121690_15121691delCC	ENST00000292574.3	+	1	135_136	c.53_54delCC	c.(52-54)gfs	p.A18fs		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	18					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CGCGTTGGGGCCCCAGCATGGC	0.698													6	4	---	---	---	---					
NCR2	9436	broad.mit.edu	37	6	41303645	41303647	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr6:41303645_41303647delCTG	ENST00000373083.4	+	1	253_255	c.31_33delCTG	c.(31-33)del	p.L15del	NCR2_ENST00000373086.3_In_Frame_Del_p.L15del|NCR2_ENST00000373089.5_In_Frame_Del_p.L15del	NM_001199510.1	NP_001186439.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	15					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCACTGCTACTGCTGCTGCTGC	0.635													2	4	---	---	---	---					
TMEM184A	202915	broad.mit.edu	37	7	1586653	1586654	+	In_Frame_Ins	INS	-	-	GCC	rs112463195	by1000genomes	TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr7:1586653_1586654insGCC	ENST00000297477.5	-	9	1492_1493	c.1176_1177insGGC	c.(1174-1179)ggccgg>ggGGCccgg	p.392_393GR>GAR		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	392						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTCCCGCCGGAGCCGCCGCTGG	0.708													6	13	---	---	---	---					
LURAP1L	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	-	GGCGGCGGC	rs3833707	by1000genomes	TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr9:12775861_12775862insGGCGGCGGC	ENST00000319264.3	+	1	842_843	c.147_148insGGCGGCGGC	c.(145-150)gggcgg>ggGGCGGCGGCgcgg	p.49_50GR>GAAAR	LURAP1L_ENST00000489107.1_3'UTR|RP11-3L8.3_ENST00000417638.1_RNA	NM_203403.1	NP_981948.1	Q8IV03	CI150_HUMAN	leucine rich adaptor protein 1-like	49	Gly-rich.		Missing.					p.G49_G50insGGG(2)|p.G50_G52delGGG(1)									gcggtggtggtggcggcggcgg	0.688													2	4	---	---	---	---					
FAM74A3	0	broad.mit.edu	37	9	40715923	40715924	+	RNA	DEL	AA	AA	-	rs62565543		TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr9:40715923_40715924delAA	ENST00000604146.1	+	0	262_263					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAGACGTGGAAAGAGCTCAGA	0.569													3	5	---	---	---	---					
MAP2K1	5604	broad.mit.edu	37	15	66727443	66727457	+	In_Frame_Del	DEL	TCTTACCCAGAAGCA	TCTTACCCAGAAGCA	-			TCGA-SQ-A6I4-01A-11D-A35I-08	TCGA-SQ-A6I4-11A-11D-A35I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe7f0f4e-0379-466c-88ed-acd18efae6d4	89317873-c294-4d2a-8c09-7010dc095a7d	g.chr15:66727443_66727457delTCTTACCCAGAAGCA	ENST00000307102.5	+	2	690_704	c.159_173delTCTTACCCAGAAGCA	c.(157-174)ttg>tt	p.FLTQKQ53del		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	53			F -> S (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K57N(3)|p.K57T(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						TTGAGGCCTTTCTTACCCAGAAGCAGAAGGTGGGA	0.553													15	96	---	---	---	---					
