Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AKAP13	11214	broad.mit.edu	37	15	86198964	86198964	+	Missense_Mutation	SNP	A	A	G			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr15:86198964A>G	ENST00000394518.2	+	11	4786	c.4691A>G	c.(4690-4692)cAc>cGc	p.H1564R	AKAP13_ENST00000361243.2_Missense_Mutation_p.H1564R|AKAP13_ENST00000560579.1_3'UTR|RP11-815J21.4_ENST00000558980.1_RNA	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1564					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TTCCGGAGGCACAGCTGGGGG	0.562000													28	31					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292809	102292809	+	RNA	SNP	C	C	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr15:102292809C>A	ENST00000561463.1	+	0	855																											AACCTGCACTCGCGTGGGAAC	0.602000													3	40					0.000157383	0.000160805	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													8	73					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890950	32890950	+	RNA	SNP	A	A	G	rs151263854	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr16:32890950A>G	ENST00000330048.5	-	0	3016					NR_003083.2																						ATACACCCAGACCACCACCAC	0.637000													4	56					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144891186	144891186	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144891186G>A	ENST00000356994.2	-	15	1714	c.1708C>T	c.(1708-1710)Cat>Tat	p.H570Y	SCRIB_ENST00000377533.3_Missense_Mutation_p.H489Y|SCRIB_ENST00000320476.3_Missense_Mutation_p.H570Y	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	570	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCTGCGAAATGCACCGTGGGC	0.657000													33	31					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3723762	3723762	+	Missense_Mutation	SNP	T	T	C			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr11:3723762T>C	ENST00000324932.7	-	23	3863	c.3443A>G	c.(3442-3444)gAa>gGa	p.E1148G	NUP98_ENST00000359171.4_Missense_Mutation_p.E1148G|NUP98_ENST00000355260.3_Missense_Mutation_p.E1148G	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1165					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ATTTTCTAGTTCATGAGAGCC	0.458000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								7	82					0	0	1	0	0
TCAP	8557	broad.mit.edu	37	17	37822231	37822231	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:37822231G>A	ENST00000309889.2	+	2	1546	c.373G>A	c.(373-375)Ggc>Agc	p.G125S	TCAP_ENST00000578283.1_Missense_Mutation_p.G101S			O15273	TELT_HUMAN	titin-cap	125					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding			kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AGCCCTGGGTGGCCAGTGTGT	0.662000													15	38					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	84					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	51					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17084968	17084968	+	RNA	SNP	G	G	C	rs2761533		TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr1:17084968G>C	ENST00000455405.2	-	0	220																		p.R472G(1)|p.R503G(1)									CACCGATTCCGCAAGCTGACT	0.617000													3	28					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	40					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70117789	70117789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:70117789G>A	ENST00000245479.2	+	1	629	c.257G>A	c.(256-258)tGg>tAg	p.W86*		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	86					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GGCTACGACTGGACGCTGGTG	0.652000													4	1					0	0	1	0	0
TCAP	8557	broad.mit.edu	37	17	37822179	37822179	+	Missense_Mutation	SNP	G	G	C			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:37822179G>C	ENST00000309889.2	+	2	1494	c.321G>C	c.(319-321)gaG>gaC	p.E107D	TCAP_ENST00000578283.1_Missense_Mutation_p.E83D			O15273	TELT_HUMAN	titin-cap	107					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding			kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AGGAGCGTGAGGACACCCCCA	0.662000													6	22					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468631	10468631	+	Missense_Mutation	SNP	C	C	T	rs144078596	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:10468631C>T	ENST00000382483.3	-	4	3200	c.2977G>A	c.(2977-2979)Gac>Aac	p.D993N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	993					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCCCCAGGGTCCACCTCGGGG	0.642000													23	62					0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94884143	94884143	+	Splice_Site	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr1:94884143G>A	ENST00000370214.4	+	1	133	c.110_splice	c.e1+1	p.G37_splice	ABCD3_ENST00000315713.5_Splice_Site_p.G37_splice|ABCD3_ENST00000536817.1_5'UTR|ABCD3_ENST00000394233.2_Splice_Site_p.G37_splice|ABCD3_ENST00000454898.2_Splice_Site_p.G37_splice	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	37	Interaction with PEX19.|Targeting to peroxisomes.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CGGCCTGCACGGGTAAGAAGG	0.701000													3	18					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144890795	144890795	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144890795G>A	ENST00000356994.2	-	15	2105	c.2099C>T	c.(2098-2100)tCt>tTt	p.S700F	SCRIB_ENST00000377533.3_Missense_Mutation_p.S619F|SCRIB_ENST00000320476.3_Missense_Mutation_p.S700F	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	700	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding	p.S700F(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGAGGGCGCAGAAACCACGGC	0.652000													25	21					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63042971	63042971	+	Missense_Mutation	SNP	C	C	G			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr1:63042971C>G	ENST00000251157.5	-	18	2107	c.2074G>C	c.(2074-2076)Gaa>Caa	p.E692Q	DOCK7_ENST00000340370.5_Missense_Mutation_p.E692Q	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	692	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						GGTGGTTTTTCCAATGAGACT	0.368000													42	53					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179193271	179193271	+	Silent	SNP	G	G	T			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr5:179193271G>T	ENST00000292599.3	+	2	1523	c.1260G>T	c.(1258-1260)ccG>ccT	p.P420P	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	420					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGCCACCCCGGCACCAGCCC	0.652000													4	104					0.00024832	0.00024832	1	1	0
WHSC1	7468	broad.mit.edu	37	4	1918661	1918661	+	Missense_Mutation	SNP	G	G	T			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr4:1918661G>T	ENST00000503128.1	+	4	1031	c.824G>T	c.(823-825)tGg>tTg	p.W275L	WHSC1_ENST00000382892.2_Missense_Mutation_p.W275L|WHSC1_ENST00000514045.1_Missense_Mutation_p.W275L|WHSC1_ENST00000382895.3_Missense_Mutation_p.W275L|WHSC1_ENST00000382891.5_Missense_Mutation_p.W275L|WHSC1_ENST00000398261.1_Missense_Mutation_p.W275L|WHSC1_ENST00000420906.2_Missense_Mutation_p.W275L|WHSC1_ENST00000508803.1_Missense_Mutation_p.W275L			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	275	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAAGAGCTTGGATATTTGAG	0.408000			T	IGH@	MM								12	85					2.27111e-07	2.37205e-07	1	1	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													4	7					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169025544	169025544	+	Missense_Mutation	SNP	A	A	G			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr5:169025544A>G	ENST00000265295.4	+	9	1376	c.1097A>G	c.(1096-1098)tAt>tGt	p.Y366C		NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		GATAACACCTATTATACAGAT	0.343000													47	50					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467864	10467864	+	Silent	SNP	C	C	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:10467864C>A	ENST00000382483.3	-	4	3967	c.3744G>T	c.(3742-3744)ggG>ggT	p.G1248G		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1248					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TTTCCAGATCCCCTGGGCTCT	0.552000													23	43					4.26978e-12	4.66697e-12	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10467982	10467982	+	Missense_Mutation	SNP	C	C	T			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:10467982C>T	ENST00000382483.3	-	4	3849	c.3626G>A	c.(3625-3627)gGc>gAc	p.G1209D		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1209					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCCCCTGAGCCTCCAGAGCC	0.607000													15	30					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144892898	144892898	+	Silent	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144892898G>A	ENST00000356994.2	-	12	1368	c.1362C>T	c.(1360-1362)ccC>ccT	p.P454P	SCRIB_ENST00000377533.3_Silent_p.P373P|SCRIB_ENST00000320476.3_Silent_p.P454P	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	454	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CATCACCTATGGGGGCCTCCA	0.662000													58	65					0	0	1	0	0
TCAP	8557	broad.mit.edu	37	17	37822068	37822068	+	Silent	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:37822068G>A	ENST00000309889.2	+	2	1383	c.210G>A	c.(208-210)cgG>cgA	p.R70R	TCAP_ENST00000578283.1_Intron			O15273	TELT_HUMAN	titin-cap	70			R -> W (in CMD1N).		adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding			kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGATGATGCGGATGGGCATCC	0.662000													8	6					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35387985	35387985	+	Missense_Mutation	SNP	A	A	G			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr6:35387985A>G	ENST00000311565.4	+	5	561	c.212A>G	c.(211-213)aAc>aGc	p.N71S	PPARD_ENST00000360694.3_Missense_Mutation_p.N71S|PPARD_ENST00000337400.2_Missense_Mutation_p.N71S|PPARD_ENST00000448077.2_Missense_Mutation_p.N32S|PPARD_ENST00000418635.2_Intron|PPARD_ENST00000444397.1_Missense_Mutation_p.N71S|PPARD_ENST00000540939.1_Intron	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	71					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GGCAGCCTCAACATGGAGTGC	0.652000													3	53					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72685542	72685542	+	RNA	SNP	G	G	A	rs2539086		TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr7:72685542G>A	ENST00000425256.1	-	0	116					NR_002164.1																						ACGTTACCATGACAAAAGCAG	0.463000													4	155					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144895531	144895531	+	Missense_Mutation	SNP	G	G	C			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144895531G>C	ENST00000356994.2	-	6	523	c.517C>G	c.(517-519)Ctg>Gtg	p.L173V	SCRIB_ENST00000377533.3_Missense_Mutation_p.L92V|SCRIB_ENST00000320476.3_Missense_Mutation_p.L173V	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	173	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCTTGACCAGAAATGACAGG	0.642000													29	55					0	0	1	0	0
TCAP	8557	broad.mit.edu	37	17	37822170	37822170	+	Silent	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:37822170G>A	ENST00000309889.2	+	2	1485	c.312G>A	c.(310-312)gaG>gaA	p.E104E	TCAP_ENST00000578283.1_Silent_p.E80E			O15273	TELT_HUMAN	titin-cap	104					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding			kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCACCAAGGAGGAGCGTGAGG	0.662000													5	19					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119962585	119962585	+	Missense_Mutation	SNP	T	T	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr3:119962585T>A	ENST00000464295.1	-	3	580	c.135A>T	c.(133-135)ttA>ttT	p.L45F	GPR156_ENST00000461057.1_Missense_Mutation_p.L45F|GPR156_ENST00000315843.3_Missense_Mutation_p.L45F			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	45						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GGACAGGAGATAATGAAGAGA	0.423000													20	7					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144891006	144891006	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144891006G>A	ENST00000356994.2	-	15	1894	c.1888C>T	c.(1888-1890)Cag>Tag	p.Q630*	SCRIB_ENST00000377533.3_Nonsense_Mutation_p.Q549*|SCRIB_ENST00000320476.3_Nonsense_Mutation_p.Q630*	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	630	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGCATGCCCTGCAGCAGAGCC	0.667000													53	85					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27918013	27918013	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:27918013G>A	ENST00000413272.2	-	8	1169	c.1027C>T	c.(1027-1029)Cgg>Tgg	p.R343W	NUGGC_ENST00000341513.6_Missense_Mutation_p.R343W	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		CAGAAGCCCCGCTGGCAGGCT	0.552000											OREG0018675	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	17					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25264280	25264280	+	Missense_Mutation	SNP	G	G	C			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr16:25264280G>C	ENST00000328086.7	-	3	1468	c.665C>G	c.(664-666)cCt>cGt	p.P222R		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	222					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GGACCCAGCAGGAAGCCGTGT	0.493000													4	157					0	0	1	0	0
GOSR2	9570	broad.mit.edu	37	17	45012514	45012514	+	Silent	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr17:45012514G>A	ENST00000415811.2	+	5	511	c.456G>A	c.(454-456)agG>agA	p.R152R	GOSR2_ENST00000393456.2_Silent_p.R152R|RP11-156P1.2_ENST00000571841.1_Silent_p.R152R|GOSR2_ENST00000225567.4_Silent_p.R152R|GOSR2_ENST00000439730.2_Silent_p.R152R|GOSR2_ENST00000576910.2_Intron	NM_001012511.1	NP_001012529.1	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2	152					cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			kidney(1)|large_intestine(2)|liver(1)|lung(1)|ovary(1)|skin(1)	7			BRCA - Breast invasive adenocarcinoma(9;0.102)			ATGGACTGAGGACCCAGAGAC	0.463000													39	54					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144886884	144886884	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144886884G>A	ENST00000356994.2	-	21	2869	c.2863C>T	c.(2863-2865)Cct>Tct	p.P955S	SCRIB_ENST00000377533.3_Missense_Mutation_p.P874S|SCRIB_ENST00000320476.3_Missense_Mutation_p.P955S	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	955	Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGGCTGGGAGGAAGAGGGCCC	0.697000													11	10					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21226240	21226240	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr1:21226240G>A	ENST00000602326.1	-	14	2382	c.1799C>T	c.(1798-1800)tCa>tTa	p.S600L	EIF4G3_ENST00000374933.3_5'UTR|EIF4G3_ENST00000544689.1_Missense_Mutation_p.S137L|EIF4G3_ENST00000537738.1_Missense_Mutation_p.S47L|EIF4G3_ENST00000374935.3_Missense_Mutation_p.S314L|EIF4G3_ENST00000374937.3_Missense_Mutation_p.S600L|EIF4G3_ENST00000400422.1_Missense_Mutation_p.S594L|EIF4G3_ENST00000536266.1_Missense_Mutation_p.S198L|EIF4G3_ENST00000264211.8_Missense_Mutation_p.S594L	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	594					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGTGGAGCCTGAATTAGCATC	0.423000													28	177					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144888620	144888620	+	Missense_Mutation	SNP	G	G	C			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr8:144888620G>C	ENST00000356994.2	-	18	2309	c.2303C>G	c.(2302-2304)cCt>cGt	p.P768R	SCRIB_ENST00000377533.3_Missense_Mutation_p.P687R|SCRIB_ENST00000320476.3_Missense_Mutation_p.P768R	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	768	Interaction with ARHGEF7.|PDZ 1.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCGGGCCGCAGGGCCTTCCTC	0.657000													6	7					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31622624	31622624	+	Missense_Mutation	SNP	C	C	T			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr20:31622624C>T	ENST00000349552.1	+	4	358	c.358C>T	c.(358-360)Cgg>Tgg	p.R120W		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	120						extracellular region	lipid binding										AGCCACCAACCGGCTTCTGCG	0.577000													21	37					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058248	11058248	+	RNA	SNP	G	G	A	rs8130203	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr21:11058248G>A	ENST00000470054.1	-	0	399									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAGCACAAGGATAATGATAC	0.433000													4	117					0	0	1	0	0
PRRT3	285368	broad.mit.edu	37	3	9989643	9989643	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr3:9989643delG	ENST00000412055.1	-	4	1343	c.1214delC	c.(1213-1215)cafs	p.P405fs	PRRT3-AS1_ENST00000431558.1_RNA	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	405	Pro-rich.					integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						TGGGGGTGCTGGGGGATGGCT	0.602													2	4	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													4	2	---	---	---	---					
LEPREL2	10536	broad.mit.edu	37	12	6948498	6948500	+	RNA	DEL	AGG	AGG	-			TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr12:6948498_6948500delAGG	ENST00000251761.8	+	0	2117_2119				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						CAGGAGTCACaggaggaggagga	0.606													2	4	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546140	3546141	+	RNA	INS	-	-	A	rs74546027		TCGA-SR-A6MP-01A-11D-A35I-08	TCGA-SR-A6MP-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a33eeb-0950-4883-a62a-91f4f2ab7f5f	e0435371-7d5c-44fb-aae8-2e7796e59898	g.chr16:3546140_3546141insA	ENST00000574423.2	+	0	111																											gactccgtctcaaaaaaaaaaa	0.559													2	4	---	---	---	---					
