Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC39A8	64116	broad.mit.edu	37	4	103228643	103228643	+	Missense_Mutation	SNP	G	G	C			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr4:103228643G>C	ENST00000424970.2	-	4	817	c.502C>G	c.(502-504)Ctg>Gtg	p.L168V	SLC39A8_ENST00000510255.1_5'UTR|SLC39A8_ENST00000356736.4_Missense_Mutation_p.L168V|SLC39A8_ENST00000394833.2_Missense_Mutation_p.L168V	NM_001135147.1	NP_001128619.1	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter), member 8	168						integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity			large_intestine(1)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		CCAATAGCCAGCCCCACAAAA	0.363000													5	132					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234891753	234891753	+	Silent	SNP	C	C	T	rs144605883		TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr2:234891753C>T	ENST00000324695.4	+	20	2686	c.2646C>T	c.(2644-2646)ggC>ggT	p.G882G	TRPM8_ENST00000433712.2_Silent_p.G460G	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	882						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGGCCTTTGGCGTGGCCAGGC	0.592000													4	160					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													3	60					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77354692	77354692	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr9:77354692G>A	ENST00000451710.3	-	33	5683	c.5446C>T	c.(5446-5448)Cgg>Tgg	p.R1816W	TRPM6_ENST00000361255.3_Missense_Mutation_p.R1807W|TRPM6_ENST00000360774.1_Missense_Mutation_p.R1812W|TRPM6_ENST00000376872.3_Missense_Mutation_p.R767W|TRPM6_ENST00000376871.3_Missense_Mutation_p.R649W|TRPM6_ENST00000376864.4_Missense_Mutation_p.R1816W|TRPM6_ENST00000449912.2_Missense_Mutation_p.R1807W			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1812	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGCCATGTCCGCACAACCTCA	0.488000													4	120					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756360	94756360	+	Missense_Mutation	SNP	C	C	A			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr14:94756360C>A	ENST00000554723.1	-	2	1109	c.691G>T	c.(691-693)Gtg>Ttg	p.V231L	SERPINA10_ENST00000393096.1_Missense_Mutation_p.V191L|SERPINA10_ENST00000261994.4_Missense_Mutation_p.V191L|SERPINA10_ENST00000554173.1_Missense_Mutation_p.V191L			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	191					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTCATAGGCACGCACTCTGTA	0.418000													4	80					0.150653	0.163208	1	1	0
NKAP	79576	broad.mit.edu	37	X	119059273	119059273	+	Missense_Mutation	SNP	G	G	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chrX:119059273G>T	ENST00000371410.3	-	9	1324	c.1158C>A	c.(1156-1158)aaC>aaA	p.N386K	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	386	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						TCTCTTCTTGGTTAAAGGATG	0.438000													4	79					0.00024832	0.000307444	1	1	0
AAED1	195827	broad.mit.edu	37	9	99417014	99417014	+	Silent	SNP	C	C	G			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr9:99417014C>G	ENST00000375234.3	-	2	233	c.234G>C	c.(232-234)ctG>ctC	p.L78L	AAED1_ENST00000464512.1_5'UTR	NM_153698.1	NP_714542.1	Q7RTV5	CI021_HUMAN	AhpC/TSA antioxidant enzyme domain containing 1	78							antioxidant activity|oxidoreductase activity										GGATTTTGGCCAGATCCTCTA	0.582000													2	2					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	C	G	rs104894228		TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr11:534286C>G	ENST00000417302.1	-	2	224	c.37G>C	c.(37-39)Ggt>Cgt	p.G13R	HRAS_ENST00000311189.7_Missense_Mutation_p.G13R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Missense_Mutation_p.G13R|HRAS_ENST00000397596.2_Missense_Mutation_p.G13R|HRAS_ENST00000451590.1_Missense_Mutation_p.G13R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	13			G -> C (in FCSS).|G -> D (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(70)|p.G13S(9)|p.G13C(8)|p.G12_G13insAG(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			11	24					0	0	1	0	0
MSN	4478	broad.mit.edu	37	X	64951750	64951750	+	Missense_Mutation	SNP	A	A	G			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chrX:64951750A>G	ENST00000360270.5	+	6	774	c.602A>G	c.(601-603)tAt>tGt	p.Y201C		NM_002444.2	NP_002435.1	P26038	MOES_HUMAN	moesin	201	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	breast(4)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	43						CTGGAGATGTATGGTGTGAAC	0.493000			T	ALK	ALCL								17	80					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48032102	48032102	+	Silent	SNP	G	G	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr2:48032102G>T	ENST00000234420.4	+	6	3644	c.3492G>T	c.(3490-3492)gtG>gtT	p.V1164V	FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Silent_p.V1034V|MSH6_ENST00000538136.1_Silent_p.V862V	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	1164					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTGCTGAAGTGTGCAGGCTCA	0.438000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				3	49					1	1	1	1	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													3	40					0.115264	0.130298	1	1	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	31					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66873753	66873753	+	Missense_Mutation	SNP	G	G	A			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr17:66873753G>A	ENST00000269080.2	-	31	4123	c.3986C>T	c.(3985-3987)gCg>gTg	p.A1329V	ABCA8_ENST00000586539.1_Missense_Mutation_p.A1369V|ABCA8_ENST00000430352.2_Missense_Mutation_p.A1369V	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1329	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.A1329V(1)		breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GGGCCACAGCGCGTTCTCCTG	0.597000													4	77					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277659	152277659	+	Missense_Mutation	SNP	C	C	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr1:152277659C>T	ENST00000368799.1	-	3	9738	c.9703G>A	c.(9703-9705)Gct>Act	p.A3235T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3235	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTCTGGAAGCAGACCCAGAC	0.592000									Ichthyosis				12	210					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99117515	99117515	+	Silent	SNP	A	A	G			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr12:99117515A>G	ENST00000357310.1	+	23	3751	c.3174A>G	c.(3172-3174)tcA>tcG	p.S1058S	APAF1_ENST00000552268.1_Intron|APAF1_ENST00000359972.2_Silent_p.S1047S|APAF1_ENST00000549007.1_Silent_p.S1058S|APAF1_ENST00000550527.1_Silent_p.S1090S|APAF1_ENST00000339433.3_Silent_p.S1058S|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000551964.1_Silent_p.S1101S|APAF1_ENST00000547045.1_Silent_p.S1058S	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	1101					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	CCAAGTTTTCATCTACCTCTG	0.353000													7	110					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100258051	100258051	+	Silent	SNP	C	C	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr9:100258051C>T	ENST00000355295.4	+	17	3478	c.3183C>T	c.(3181-3183)aaC>aaT	p.N1061N	TDRD7_ENST00000540902.1_Silent_p.N381N|TDRD7_ENST00000422139.2_Silent_p.N987N	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	1061	Interacts with CABLES1 (By similarity).|Interacts with CDK17 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				AAAATGCTAACCCTTGGGACC	0.463000													7	65					0	0	1	0	0
TOP1MT	116447	broad.mit.edu	37	8	144407615	144407615	+	Missense_Mutation	SNP	A	A	G			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr8:144407615A>G	ENST00000523676.1	-	6	683	c.278T>C	c.(277-279)aTt>aCt	p.I93T	TOP1MT_ENST00000519148.1_Missense_Mutation_p.I93T|TOP1MT_ENST00000329245.4_Missense_Mutation_p.I191T|TOP1MT_ENST00000521193.1_Missense_Mutation_p.I93T			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	191					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	AGGCGGCTCAATCTTGAAGTT	0.473000													3	50					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51944754	51944754	+	Missense_Mutation	SNP	C	C	T	rs149841071		TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr6:51944754C>T	ENST00000371117.3	-	5	609	c.334G>A	c.(334-336)Ggg>Agg	p.G112R	PKHD1_ENST00000340994.4_Missense_Mutation_p.G112R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	112					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGCTGTCCCCCGAAGTATGCT	0.463000													4	117					0	0	1	0	0
MIR656	0	broad.mit.edu	37	14	101533126	101533126	+	RNA	SNP	C	C	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr14:101533126C>T	ENST00000385224.1	+	0	66					NR_030392.1																						CAACCTCTTTCCGATATCGAA	0.507000													4	79					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611367	179611367	+	Missense_Mutation	SNP	T	T	A			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr2:179611367T>A	ENST00000360870.5	-	46	15982	c.15760A>T	c.(15760-15762)Atg>Ttg	p.M5254L	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8773	Ig-like 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATGACACATGTACTCTCCC	0.418000													4	55					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75841698	75841698	+	Silent	SNP	G	G	A			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr6:75841698G>A	ENST00000322507.8	-	35	6204	c.5895C>T	c.(5893-5895)cgC>cgT	p.R1965R	COL12A1_ENST00000483888.2_Silent_p.R1965R|COL12A1_ENST00000345356.6_Silent_p.R801R|COL12A1_ENST00000416123.2_Silent_p.R1965R	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1965	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AATACACAACGCGATATTGCA	0.463000													23	25					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59418227	59418227	+	Splice_Site	DEL	T	T	-			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr11:59418227delT	ENST00000300146.9	-	13	1668	c.1584_splice	c.e13+1	p.K528_splice		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	528	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						CTAAACTTACTTTCTCAATTA	0.313													2	4	---	---	---	---					
DENND4A	10260	broad.mit.edu	37	15	66021931	66021931	+	Frame_Shift_Del	DEL	T	T	-			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr15:66021931delT	ENST00000443035.3	-	10	1467	c.1252delA	c.(1252-1254)ttfs	p.I418fs	DENND4A_ENST00000431932.2_Frame_Shift_Del_p.I418fs	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	418	DENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TGGATAAGAATTTTATGTTCT	0.403													2	4	---	---	---	---					
SNORD3B-1	0	broad.mit.edu	37	17	18965296	18965297	+	RNA	INS	-	-	T			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr17:18965296_18965297insT	ENST00000363359.1	+	0	72_73																											tagagcaccgaaaaccccgagg	0.495													2	4	---	---	---	---					
BSG	682	broad.mit.edu	37	19	577826	577826	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SR-A6MQ-01A-11D-A35I-08	TCGA-SR-A6MQ-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1437acf1-5eac-48d6-9bd6-aed2266c82e3	e593e74f-35a2-4df8-9717-7e4974edf3e0	g.chr19:577826delG	ENST00000333511.3	+	2	190	c.120delG	c.(118-120)gtfs	p.V40fs	BSG_ENST00000545507.2_Intron|BSG_ENST00000574970.1_3'UTR|BSG_ENST00000353555.4_Intron|BSG_ENST00000346916.4_Intron	NM_001728.3	NP_001719.2	P35613	BASI_HUMAN	basigin	40					blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding			central_nervous_system(1)|endometrium(3)|lung(1)	5		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCAGTGTGGAGCTGCACT	0.692													2	4	---	---	---	---					
