Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			31	31					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31805046	31805046	+	Missense_Mutation	SNP	G	G	A	rs3026403		TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:31805046G>A	ENST00000350638.5	+	10	1284	c.1249G>A	c.(1249-1251)Gga>Aga	p.G417R	ELP4_ENST00000379163.5_Missense_Mutation_p.R464Q|ELP4_ENST00000395934.2_3'UTR	NM_019040.3	NP_061913.3	Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	417					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CATGATGGCCGGAGGCAAGAA	0.498000													3	38					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62297449	62297449	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:62297449T>C	ENST00000378024.4	-	5	4714	c.4440A>G	c.(4438-4440)atA>atG	p.I1480M	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1480					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CAGGAGCTTTTATCTCTCCTT	0.423000													92	120					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152590365	152590365	+	Silent	SNP	G	G	A			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr6:152590365G>A	ENST00000367255.5	-	99	19231	c.18630C>T	c.(18628-18630)ccC>ccT	p.P6210P	SYNE1_ENST00000356820.4_Silent_p.P734P|SYNE1_ENST00000265368.4_Silent_p.P6210P|SYNE1_ENST00000423061.1_Silent_p.P6139P|SYNE1_ENST00000341594.5_Silent_p.P5822P|SYNE1_ENST00000448038.1_Silent_p.P6139P	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6210					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTGGACGCCGGGGCTCTGCG	0.547000										HNSCC(10;0.0054)			29	48					0	0	1	0	0
PRSS3P2	0	broad.mit.edu	37	7	142481888	142481888	+	RNA	SNP	T	T	C	rs138077672	by1000genomes	TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr7:142481888T>C	ENST00000603901.1	+	0	567					NR_001296.3																						TGGGCTTCCTTGAGGGAGGCA	0.522000													3	31					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23956667	23956667	+	Silent	SNP	T	T	A			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chrX:23956667T>A	ENST00000379211.3	+	8	1338	c.789T>A	c.(787-789)ggT>ggA	p.G263G		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	263										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						TTTCTAGGGGTCCATACTTAA	0.333000													4	95					0	0	1	0	0
ATP9B	374868	broad.mit.edu	37	18	76953241	76953241	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr18:76953241G>A	ENST00000426216.2	+	9	949	c.932G>A	c.(931-933)aGt>aAt	p.S311N	ATP9B_ENST00000307671.7_Missense_Mutation_p.S311N	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	311					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		GACATTCACAGTTTCGAAGGC	0.333000													4	87					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161529848	161529848	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr6:161529848A>G	ENST00000392142.4	+	22	4341	c.4193A>G	c.(4192-4194)aAa>aGa	p.K1398R	MAP3K4_ENST00000366919.2_Missense_Mutation_p.K1348R|MAP3K4_ENST00000366920.2_Missense_Mutation_p.K1394R|MAP3K4_ENST00000348824.7_Missense_Mutation_p.K1344R	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1398	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GAAGGCATCAAACACCCCAAT	0.423000													5	141					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63669773	63669773	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:63669773A>G	ENST00000402010.2	+	12	1784	c.1205A>G	c.(1204-1206)aAt>aGt	p.N402S	MARK2_ENST00000502399.3_Missense_Mutation_p.N402S|MARK2_ENST00000513765.2_Missense_Mutation_p.N369S|MARK2_ENST00000509502.2_Missense_Mutation_p.N369S|MARK2_ENST00000377809.4_Missense_Mutation_p.N402S|MARK2_ENST00000350490.7_Missense_Mutation_p.N402S|MARK2_ENST00000425897.2_Missense_Mutation_p.N369S|MARK2_ENST00000377810.3_Missense_Mutation_p.N369S|MARK2_ENST00000361128.5_Missense_Mutation_p.N402S|MARK2_ENST00000408948.3_Missense_Mutation_p.N369S|MARK2_ENST00000315032.8_Missense_Mutation_p.N402S|MARK2_ENST00000508192.1_Missense_Mutation_p.N402S|MARK2_ENST00000413835.2_Missense_Mutation_p.N402S	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	402					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						GTGTCGGCCAATCCCAAGCAG	0.592000													19	31					0	0	1	0	0
SCGB3A2	117156	broad.mit.edu	37	5	147261032	147261032	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr5:147261032G>A	ENST00000296694.4	+	2	172	c.79G>A	c.(79-81)Gtg>Atg	p.V27M	SCGB3A2_ENST00000514688.1_3'UTR|C5orf46_ENST00000510432.1_Intron|SCGB3A2_ENST00000504320.1_5'UTR	NM_054023.4	NP_473364.1	Q96PL1	SG3A2_HUMAN	secretoglobin, family 3A, member 2	27						extracellular region	binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCAACAAAGTGCCCCTTCC	0.473000													7	85					0	0	1	0	0
MIR329-1	0	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	A	T			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr14:101493161A>T	ENST00000385028.1	+	0	40					NR_029967.1																						TGTTTCTTTAATGAGGACGAA	0.468000													4	167					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169847313	169847313	+	Missense_Mutation	SNP	G	G	T			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr3:169847313G>T	ENST00000494943.1	-	8	979	c.911C>A	c.(910-912)tCt>tAt	p.S304Y	PHC3_ENST00000495893.1_Missense_Mutation_p.S316Y|PHC3_ENST00000467570.1_Missense_Mutation_p.S263Y			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	304					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTTTATTAGAGAATGAGGCTG	0.343000													12	34					3.27435e-08	3.39129e-08	1	1	0
ACAD10	80724	broad.mit.edu	37	12	112165863	112165863	+	Missense_Mutation	SNP	A	A	G	rs140075311		TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr12:112165863A>G	ENST00000455480.2	+	10	1429	c.1252A>G	c.(1252-1254)Ata>Gta	p.I418V	ACAD10_ENST00000313698.4_Missense_Mutation_p.I387V|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000549590.1_Missense_Mutation_p.I387V|ACAD10_ENST00000392636.2_Intron	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	387							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CAGACGAGCCATATACACTGC	0.542000													5	167					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154684108	154684108	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr7:154684108T>C	ENST00000404039.1	+	26	2911	c.2324T>C	c.(2323-2325)aTc>aCc	p.I775T	DPP6_ENST00000427557.1_Missense_Mutation_p.I732T|DPP6_ENST00000377770.3_Missense_Mutation_p.I839T|DPP6_ENST00000332007.3_Missense_Mutation_p.I777T	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	839					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TACCGGTCCATCATCAACTTC	0.512000													19	27					0	0	1	0	0
GUSBP1	0	broad.mit.edu	37	5	21497235	21497235	+	RNA	SNP	C	C	T	rs141635554	by1000genomes	TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr5:21497235C>T	ENST00000607545.1	+	0	179					NR_027026.1																						AGTTTGAGAACTGGTGTAAGA	0.488000													4	8					0	0	1	0	0
RUFY1	80230	broad.mit.edu	37	5	178994549	178994549	+	Silent	SNP	T	T	C			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr5:178994549T>C	ENST00000377001.2	+	4	690	c.690T>C	c.(688-690)aaT>aaC	p.N230N	RUFY1_ENST00000437570.2_Silent_p.N122N|RUFY1_ENST00000319449.4_Silent_p.N230N|RUFY1_ENST00000393438.2_Silent_p.N122N			Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	230	RUN.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTATAGACAATAAACATCTCT	0.418000										HNSCC(44;0.11)			17	21					0	0	1	0	0
METTL21A	151194	broad.mit.edu	37	2	208486586	208486586	+	Missense_Mutation	SNP	G	G	C			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr2:208486586G>C	ENST00000411432.1	-	3	419	c.203C>G	c.(202-204)tCt>tGt	p.S68C	METTL21A_ENST00000406927.2_Missense_Mutation_p.S68C|METTL21A_ENST00000458426.1_Missense_Mutation_p.S68C|METTL21A_ENST00000448823.2_Intron|METTL21A_ENST00000448007.2_Missense_Mutation_p.S68C|METTL21A_ENST00000442521.1_Missense_Mutation_p.S68C|METTL21A_ENST00000432416.1_Missense_Mutation_p.S68C|METTL21A_ENST00000426075.1_Missense_Mutation_p.S68C|METTL21A_ENST00000425132.1_Missense_Mutation_p.S68C|METTL21A_ENST00000272839.3_Missense_Mutation_p.S68C	NM_001127395.1	NP_001120867.1	Q8WXB1	MT21A_HUMAN	methyltransferase like 21A	68						integral to membrane	methyltransferase activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|stomach(1)	10						CTCCACGGCAGAGCGGCCCCT	0.557000													31	35					0	0	1	0	0
TMEM126B	55863	broad.mit.edu	37	11	85342776	85342776	+	Missense_Mutation	SNP	C	C	G			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:85342776C>G	ENST00000534341.1	+	2	133	c.127C>G	c.(127-129)Cta>Gta	p.L43V	TMEM126B_ENST00000393375.1_Missense_Mutation_p.L13V|TMEM126B_ENST00000358867.6_Missense_Mutation_p.L43V			Q8IUX1	T126B_HUMAN	transmembrane protein 126B	43						integral to membrane				kidney(1)|large_intestine(2)|lung(3)|prostate(1)	7		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CAGTCCTTCTCTAGAAGATGC	0.343000													6	53					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402858	124402858	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr10:124402858G>A	ENST00000338354.3	+	53	7292	c.7186G>A	c.(7186-7188)Gtc>Atc	p.V2396I	DMBT1_ENST00000368955.3_Missense_Mutation_p.V2386I|DMBT1_ENST00000330163.4_Missense_Mutation_p.V1768I|DMBT1_ENST00000344338.3_Missense_Mutation_p.V2386I|DMBT1_ENST00000359586.6_Missense_Mutation_p.V1116I|DMBT1_ENST00000368956.2_Missense_Mutation_p.V1768I|DMBT1_ENST00000368909.3_Missense_Mutation_p.V2396I			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2396					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGTGGACGTCGTCCTGGGTCC	0.647000													19	18					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113699965	113699965	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr11:113699965T>C	ENST00000003302.4	-	10	1081	c.1013A>G	c.(1012-1014)gAt>gGt	p.D338G	USP28_ENST00000537706.1_Missense_Mutation_p.D338G|USP28_ENST00000545540.1_Missense_Mutation_p.D213G|USP28_ENST00000544967.1_Missense_Mutation_p.D46G|USP28_ENST00000260188.5_Missense_Mutation_p.D338G	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	338					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AAGCTCAACATCACCCTCCAC	0.478000													29	21					0	0	1	0	0
AC073321.4	0	broad.mit.edu	37	2	217475032	217475032	+	RNA	DEL	A	A	-	rs71401156		TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr2:217475032delA	ENST00000441803.1	+	0	195																											ATTTTATTTCAAAAAAAAAAA	0.373													3	4	---	---	---	---					
PCDHB10	0	broad.mit.edu	37	5	140574170	140574175	+	In_Frame_Del	DEL	AGGCCG	AGGCCG	-	rs58244182	byFrequency	TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr5:140574170_140574175delAGGCCG	ENST00000239446.4	+	1	2229_2234	c.2045_2050delAGGCCG	c.(2044-2052)cag>c	p.QAE682del		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		682					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCAGGCCCAGGCCGAGGCCGACTT	0.704													12	87	---	---	---	---					
CTC-338M12.4	0	broad.mit.edu	37	5	180699086	180699087	+	RNA	INS	-	-	A	rs149736603		TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr5:180699086_180699087insA	ENST00000511331.1	+	0	918_919				CTC-338M12.3_ENST00000507434.1_RNA																							CTTTCCATCAGAAAAAAAAAAA	0.406													2	4	---	---	---	---					
PPM1E	22843	broad.mit.edu	37	17	56833457	56833458	+	In_Frame_Ins	INS	-	-	GAACCC	rs72376816	by1000genomes	TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr17:56833457_56833458insGAACCC	ENST00000308249.2	+	1	228_229	c.99_100insGAACCC	c.(97-102)ccaacc>ccGAACCCaacc	p.32_33insPN		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	32	11 X 2 AA tandem repeats of P-E.|Glu-rich.|Pro-rich.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			agccggagccggaacccgaacc	0.673													3	6	---	---	---	---					
CBX4	8535	broad.mit.edu	37	17	77807917	77807918	+	In_Frame_Ins	INS	-	-	GCCGCC			TCGA-W2-A7HD-01A-11D-A35I-08	TCGA-W2-A7HD-10D-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	face6668-e895-4c3e-90df-0458d0ca4b71	b47faef1-217c-4eb1-bca9-c8863ec1ab6c	g.chr17:77807917_77807918insGCCGCC	ENST00000269397.4	-	5	1700_1701	c.1523_1524insGGCGGC	c.(1522-1524)ggc>gGGCGGCgc	p.508_509insRR		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	508	Interaction with BMI1.|Poly-Ala.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TGGGTgccgctgccgccgccac	0.683													13	37	---	---	---	---					
