Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNPO2	30000	broad.mit.edu	37	19	12830080	12830080	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr19:12830080G>A	ENST00000425528.1	-	4	527	c.170C>T	c.(169-171)tCa>tTa	p.S57L	TNPO2_ENST00000588216.1_Missense_Mutation_p.S57L|TNPO2_ENST00000441499.1_Missense_Mutation_p.S57L|TNPO2_ENST00000592287.1_Missense_Mutation_p.S57L|TNPO2_ENST00000589956.1_5'UTR|TNPO2_ENST00000356861.5_Missense_Mutation_p.S57L|TNPO2_ENST00000450764.2_Missense_Mutation_p.S57L			O14787	TNPO2_HUMAN	transportin 2	57	Importin N-terminal.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGTACCTTCTGACTTGAGTCT	0.542000													13	30					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942926	119942926	+	Missense_Mutation	SNP	G	G	A	rs146647643	byFrequency	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr12:119942926G>A	ENST00000327554.2	+	7	1166	c.701G>A	c.(700-702)cGg>cAg	p.R234Q	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	234								p.R234Q(1)		endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AAACCAAGCCGGCGAGGCTCC	0.547000													57	107					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													6	174					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80667072	80667072	+	Silent	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr16:80667072C>T	ENST00000299564.8	-	3	833	c.678G>A	c.(676-678)gcG>gcA	p.A226A	CDYL2_ENST00000566173.1_Silent_p.A227A|CDYL2_ENST00000562812.1_Silent_p.A227A|CDYL2_ENST00000563890.1_Silent_p.A227A	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	226						nucleus	catalytic activity|protein binding	p.A226A(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						AGTCCTTCTCCGCTTCCAGCT	0.488000													46	87					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y|FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													5	116					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													5	93					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													6	106					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104713352	104713352	+	Silent	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr12:104713352C>T	ENST00000526691.1	+	7	1140	c.684C>T	c.(682-684)taC>taT	p.Y228Y	TXNRD1_ENST00000526390.1_Silent_p.Y220Y|TXNRD1_ENST00000525566.1_Silent_p.Y326Y|TXNRD1_ENST00000524698.1_Silent_p.Y176Y|TXNRD1_ENST00000503506.2_Silent_p.Y176Y|TXNRD1_ENST00000427956.1_Silent_p.Y291Y|TXNRD1_ENST00000397736.2_Silent_p.Y220Y|TXNRD1_ENST00000388854.3_Silent_p.Y228Y|TXNRD1_ENST00000378070.4_Silent_p.Y275Y|TXNRD1_ENST00000354940.6_Silent_p.Y176Y|TXNRD1_ENST00000429002.2_Silent_p.Y326Y|TXNRD1_ENST00000542918.1_Silent_p.Y226Y|TXNRD1_ENST00000540716.1_Silent_p.Y138Y|TXNRD1_ENST00000529546.1_Silent_p.Y138Y|TXNRD1_ENST00000526950.1_Silent_p.Y245Y	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	326					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						ACAAAGAATACTGCATCAGCA	0.398000													3	9					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371680	19371680	+	Missense_Mutation	SNP	C	C	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr19:19371680C>A	ENST00000291481.7	-	3	489	c.426G>T	c.(424-426)gaG>gaT	p.E142D	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	142	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			TGACTTCGCACTCATAGCGCC	0.622000													33	36					9.65021e-13	1.00698e-12	1	1	0
RAD50	10111	broad.mit.edu	37	5	131931305	131931305	+	Silent	SNP	T	T	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr5:131931305T>A	ENST00000378823.3	+	13	2411	c.1593T>A	c.(1591-1593)atT>atA	p.I531I	RAD50_ENST00000265335.6_Silent_p.I670I	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	670					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAGTTCATTACTCAGCTAA	0.388000								Homologous recombination					51	77					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196645148	196645148	+	Missense_Mutation	SNP	G	G	A	rs121913058		TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:196645148G>A	ENST00000367429.4	+	4	620	c.380G>A	c.(379-381)cGt>cAt	p.R127H	CFH_ENST00000359637.2_Missense_Mutation_p.R127H|CFH_ENST00000439155.2_Missense_Mutation_p.R127H	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	127	Sushi 2.		R -> L (in CFH deficiency; with membranoproliferative glomerulonephritis).		complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ATTAATTACCGTGAATGTGAC	0.308000													38	53					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154309900	154309900	+	Missense_Mutation	SNP	G	G	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:154309900G>T	ENST00000368489.3	+	12	1013	c.1013G>T	c.(1012-1014)cGt>cTt	p.R338L	ATP8B2_ENST00000341822.2_Missense_Mutation_p.R324L|ATP8B2_ENST00000426445.1_3'UTR|ATP8B2_ENST00000368487.3_Missense_Mutation_p.R305L	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	324					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.R338H(1)	IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTGGGGATGCGTTTCCAGGTC	0.552000													89	123					3.28864e-39	3.50788e-39	1	1	0
LSM11	134353	broad.mit.edu	37	5	157182115	157182115	+	Missense_Mutation	SNP	T	T	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr5:157182115T>A	ENST00000286307.5	+	4	982	c.926T>A	c.(925-927)gTg>gAg	p.V309E		NM_173491.2	NP_775762.1	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	309					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCTCCAGTGTGGGAGGTACC	0.572000													38	50					0	0	1	0	0
PAIP1	10605	broad.mit.edu	37	5	43535001	43535001	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr5:43535001G>A	ENST00000306846.3	-	8	1383	c.1151C>T	c.(1150-1152)tCa>tTa	p.S384L	PAIP1_ENST00000436644.2_Missense_Mutation_p.S305L|PAIP1_ENST00000514514.1_Missense_Mutation_p.S305L|PAIP1_ENST00000338972.4_Missense_Mutation_p.S272L	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	384					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					TCTATATGTTGAAGTTGCATG	0.368000													6	51					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125769796	125769796	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr10:125769796G>A	ENST00000346248.5	-	8	2197	c.1555C>T	c.(1555-1557)Cgt>Tgt	p.R519C	CHST15_ENST00000435907.1_Missense_Mutation_p.R519C	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	519					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						TCCTCGGGACGCCGTGCATTG	0.587000													15	14					0	0	1	0	0
TRIM49C	642612	broad.mit.edu	37	11	89774252	89774252	+	Missense_Mutation	SNP	G	G	A	rs145791878	by1000genomes	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr11:89774252G>A	ENST00000448984.1	+	8	1222	c.893G>A	c.(892-894)aGt>aAt	p.S298N	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	298	B30.2/SPRY.					intracellular	zinc ion binding	p.S298N(4)		endometrium(3)|kidney(1)|lung(4)	8						GAAGCCAACAGTGATATCTTT	0.323000													3	42					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29855976	29855976	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr13:29855976C>T	ENST00000431530.3	+	4	2868	c.2810C>T	c.(2809-2811)gCg>gTg	p.A937V		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	927	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TTACTTCCAGCGCCAAAATCC	0.557000													8	105					0	0	1	0	0
GPR126	0	broad.mit.edu	37	6	142764556	142764556	+	Silent	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr6:142764556C>T	ENST00000367609.3	+	25	4058	c.3657C>T	c.(3655-3657)gtC>gtT	p.V1219V	GPR126_ENST00000296932.8_3'UTR|GPR126_ENST00000230173.6_3'UTR|GPR126_ENST00000367608.2_Silent_p.V1191V	NM_198569.2	NP_940971.1	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TCCATCAGGTCATTGATAAGG	0.403000													8	86					0	0	1	0	0
PCID2	55795	broad.mit.edu	37	13	113834493	113834493	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr13:113834493G>A	ENST00000375457.2	-	11	1429	c.833C>T	c.(832-834)gCg>gTg	p.A278V	PCID2_ENST00000375459.1_Missense_Mutation_p.A278V|PCID2_ENST00000493650.1_5'UTR|PCID2_ENST00000337344.4_Missense_Mutation_p.A280V|PCID2_ENST00000375479.2_Missense_Mutation_p.A280V|PCID2_ENST00000351317.3_Missense_Mutation_p.A257V|PCID2_ENST00000246505.5_Missense_Mutation_p.A334V|PCID2_ENST00000375477.1_Missense_Mutation_p.A280V	NM_001258213.1	NP_001245142.1	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	280	PCI.				negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding	p.A334V(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)	20	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			GGTTACTTCCGCAAACTGCAT	0.433000													4	93					0	0	1	0	0
TRIM51HP	0	broad.mit.edu	37	11	55065705	55065705	+	RNA	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr11:55065705G>A	ENST00000526016.1	-	0	3					NR_038174.2																						GATGGGACAGGTGAGTTCCCT	0.483000													4	49					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													4	75					0	0	1	0	0
NCDN	23154	broad.mit.edu	37	1	36030915	36030915	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:36030915G>A	ENST00000373243.2	+	7	2224	c.1841G>A	c.(1840-1842)gGc>gAc	p.G614D	NCDN_ENST00000373253.3_Missense_Mutation_p.G597D|NCDN_ENST00000356090.4_Missense_Mutation_p.G614D	NM_014284.2	NP_055099.1	Q9UBB6	NCDN_HUMAN	neurochondrin	614					neuron projection development	cytosol|dendrite|neuronal cell body				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|pancreas(1)|skin(2)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCCACCCCGGGCTCAGACCAG	0.637000													6	73					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501827	12501827	+	Missense_Mutation	SNP	G	G	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr19:12501827G>T	ENST00000419318.1	-	4	2038	c.1289C>A	c.(1288-1290)tCc>tAc	p.S430Y	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.S462Y			Q96GE5	ZN799_HUMAN	zinc finger protein 799	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						ATTTTGAAAGGAATAGAAATC	0.388000													6	125					3.59834e-05	3.6749e-05	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								5	109					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900045	151900045	+	Silent	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chrX:151900045C>T	ENST00000393900.3	-	3	1109	c.756G>A	c.(754-756)caG>caA	p.Q252Q	MAGEA12_ENST00000393869.3_Silent_p.Q252Q|MAGEA12_ENST00000357916.4_Silent_p.Q252Q|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	252	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GGTAGTTTTCCTGCACCAAAT	0.557000													120	48					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141053009	141053009	+	Nonsense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr5:141053009G>A	ENST00000239440.4	-	6	996	c.931C>T	c.(931-933)Cag>Tag	p.Q311*	ARAP3_ENST00000508305.1_Nonsense_Mutation_p.Q233*	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	311	PH 1.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCATTGAACTGCACAAAGCGT	0.547000													24	43					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	57					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61950686	61950686	+	Silent	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr17:61950686G>A	ENST00000336844.5	-	2	175	c.24C>T	c.(22-24)tcC>tcT	p.S8S	CSH2_ENST00000392886.2_Silent_p.S8S|CSH2_ENST00000560142.1_Silent_p.S8S|CSH2_ENST00000345366.7_Silent_p.S8S	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	8					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						CCAGGAGCAGGGACGTCCGGG	0.607000													15	67					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12290895	12290895	+	Silent	SNP	G	G	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr6:12290895G>T	ENST00000379375.5	+	1	300	c.33G>T	c.(31-33)ctG>ctT	p.L11L		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	11					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				TCTCTCTGCTGTTTGTGGCTT	0.418000											OREG0017197	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	45					0.115264	0.115264	1	1	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000402731.1_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	55					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401091	11401091	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr4:11401091C>T	ENST00000002596.5	-	2	1713	c.539G>A	c.(538-540)cGc>cAc	p.R180H		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	180						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						CCTGCCATCGCGCACCAGGAA	0.592000													40	53					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983244	97983244	+	Missense_Mutation	SNP	G	G	C			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr3:97983244G>C	ENST00000383696.2	+	1	157	c.116G>C	c.(115-117)tGt>tCt	p.C39S	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C39Y(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CAACCTGACTGTAAAATACCG	0.413000													6	135					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382519	152382519	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr1:152382519T>C	ENST00000271835.3	-	3	1101	c.1039A>G	c.(1039-1041)Act>Gct	p.T347A	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	347	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTATCTGAGTGTGTCCTCCT	0.592000													4	234					0	0	1	0	0
MRPL16	54948	broad.mit.edu	37	11	59575194	59575194	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr11:59575194C>T	ENST00000300151.4	-	3	463	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K		NM_017840.3	NP_060310.1	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16	84							rRNA binding			central_nervous_system(1)|endometrium(1)|liver(1)|lung(8)	11						AAATTGCCTTCTGTAAACTCC	0.398000													4	214					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37974712	37974712	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr9:37974712G>A	ENST00000377707.3	-	3	1526	c.961C>T	c.(961-963)Cgg>Tgg	p.R321W	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	321	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TTGCTCTCCCGCAGTCGGGGG	0.597000													46	71					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20331047	20331047	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr16:20331047A>G	ENST00000302555.5	-	6	1051	c.902T>C	c.(901-903)gTc>gCc	p.V301A	GP2_ENST00000381360.5_Missense_Mutation_p.V157A|GP2_ENST00000381362.4_Missense_Mutation_p.V304A|GP2_ENST00000341642.5_Missense_Mutation_p.V154A|GP2_ENST00000573897.1_5'UTR			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	304	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GAAATCATTGACCAAGGAGAG	0.423000													69	113					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													4	87					0	0	1	0	0
RP11-262H14.3	0	broad.mit.edu	37	9	66545695	66545695	+	RNA	DEL	A	A	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr9:66545695delA	ENST00000445604.2	-	0	669																											CTGTAAGAGGAAAAAAAAACA	0.373													2	4	---	---	---	---					
PTGDR2	11251	broad.mit.edu	37	11	60620167	60620169	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr11:60620167_60620169delGCG	ENST00000332539.4	-	2	1138_1140	c.1027_1029delCGC	c.(1027-1029)del	p.R343del		NM_004778.2	NP_004769.2	Q9Y5Y4	GPR44_HUMAN	prostaglandin D2 receptor 2	343					immune response	integral to plasma membrane	N-formyl peptide receptor activity										TGGAGGAGGTGCGGCGGCGGCGG	0.749													3	6	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65918177	65918179	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr15:65918177_65918179delCTG	ENST00000261892.6	+	2	2046_2048	c.1759_1761delCTG	c.(1759-1761)del	p.L591del	SLC24A1_ENST00000339868.6_In_Frame_Del_p.L591del|SLC24A1_ENST00000546330.1_In_Frame_Del_p.L591del|SLC24A1_ENST00000399033.4_In_Frame_Del_p.L591del|SLC24A1_ENST00000544319.2_In_Frame_Del_p.L591del|SLC24A1_ENST00000537259.1_In_Frame_Del_p.L591del	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	591					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GTGGGAGAGCCTGCTGCTGCTGC	0.547													9	123	---	---	---	---					
NOX5	79400	broad.mit.edu	37	15	69328208	69328210	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr15:69328208_69328210delCTG	ENST00000260364.5	+	8	1367_1369	c.1066_1068delCTG	c.(1066-1068)del	p.L362del	NOX5_ENST00000530406.2_In_Frame_Del_p.L352del|NOX5_ENST00000455873.3_In_Frame_Del_p.L345del|NOX5_ENST00000388866.3_In_Frame_Del_p.L380del|NOX5_ENST00000448182.3_In_Frame_Del_p.L334del			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	380	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						AGGTGTCGCTCTGCTGCTGCTGC	0.626													7	354	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													3	3	---	---	---	---					
SLC46A1	113235	broad.mit.edu	37	17	26732355	26732355	+	Frame_Shift_Del	DEL	G	G	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr17:26732355delG	ENST00000440501.1	-	2	455	c.360delC	c.(358-360)gcfs	p.A120fs	SLC46A1_ENST00000584729.1_5'UTR|CTD-2350C19.2_ENST00000580714.1_RNA|SLC46A1_ENST00000321666.5_Frame_Shift_Del_p.A120fs	NM_080669.4	NP_542400.2	Q96NT5	PCFT_HUMAN	solute carrier family 46 (folate transporter), member 1	120					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity			lung(5)	5	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	GGCCCAGCGAGGCCAGCACTA	0.652													2	4	---	---	---	---					
SYT5	6861	broad.mit.edu	37	19	55689729	55689729	+	Frame_Shift_Del	DEL	G	G	-			TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr19:55689729delG	ENST00000354308.3	-	3	456	c.87delC	c.(85-87)ccfs	p.P29fs	SYT5_ENST00000537500.1_Frame_Shift_Del_p.P29fs|SYT5_ENST00000590851.1_Intron	NM_003180.2	NP_003171.2	O00445	SYT5_HUMAN	synaptotagmin V	29					energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity			kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGGGCCCAGGGGGGCACTG	0.602													3	6	---	---	---	---					
MED15	51586	broad.mit.edu	37	22	20920814	20920816	+	In_Frame_Del	DEL	CAG	CAG	-	rs71769813		TCGA-W2-A7UY-01A-11D-A35I-08	TCGA-W2-A7UY-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	20747776-f960-4a9a-ae63-4de8cbff51a2	f88e9bd8-9f29-4144-88d5-ddfa5e10231b	g.chr22:20920814_20920816delCAG	ENST00000263205.7	+	7	820_822	c.751_753delCAG	c.(751-753)del	p.Q262del	MED15_ENST00000478831.1_3'UTR|MED15_ENST00000425759.2_In_Frame_Del_p.Q151del|MED15_ENST00000382974.2_In_Frame_Del_p.Q191del|MED15_ENST00000542773.1_In_Frame_Del_p.Q67del|MED15_ENST00000406969.1_In_Frame_Del_p.Q236del|MED15_ENST00000292733.7_In_Frame_Del_p.Q262del|MED15_ENST00000541476.1_In_Frame_Del_p.Q236del	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	262	Poly-Gln.		Missing.	Missing (in Ref. 3; BAB85034).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding	p.Q250_Q251insQ(4)		central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			acaacagcaacagcagcagcagc	0.591													8	41	---	---	---	---					
