Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF311	282890	broad.mit.edu	37	6	28963545	28963545	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr6:28963545C>T	ENST00000377179.3	-	7	1746	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						TAAGGTCGTTCCCCAGTGTGG	0.512000													9	71					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	A	rs121913233		TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr11:533874T>A	ENST00000417302.1	-	3	369	c.182A>T	c.(181-183)cAg>cTg	p.Q61L	HRAS_ENST00000397596.2_Missense_Mutation_p.Q61L|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61L|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61L|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61L|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			23	70					0	0	1	0	0
FAM175B	23172	broad.mit.edu	37	10	126523309	126523309	+	Silent	SNP	T	T	C			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr10:126523309T>C	ENST00000298492.5	+	9	1062	c.1017T>C	c.(1015-1017)tcT>tcC	p.S339S		NM_032182.3	NP_115558.3	Q15018	F175B_HUMAN	family with sequence similarity 175, member B	339						BRISC complex	polyubiquitin binding			NS(1)	1						CTGTGGGCTCTTCCAATTATG	0.512000													10	23					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520392	33520392	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr17:33520392G>C	ENST00000297307.5	-	1	1020	c.935C>G	c.(934-936)gCg>gGg	p.A312G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	312	DUF6 2.					integral to membrane		p.A312G(4)									AACCCCTGCCGCCACGATGTC	0.567000													4	77					0	0	1	0	0
HOXC10	3226	broad.mit.edu	37	12	54379494	54379494	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr12:54379494G>A	ENST00000303460.4	+	1	525	c.451G>A	c.(451-453)Gcc>Acc	p.A151T		NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	151					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						CTACTACCGCGCCAGCCCGAG	0.677000													3	40					0	0	1	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354353	28354353	+	Missense_Mutation	SNP	T	T	G	rs1794256	by1000genomes	TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr16:28354353T>G	ENST00000532254.1	-	7	1538	c.853A>C	c.(853-855)Act>Cct	p.T285P	NPIPB6_ENST00000533640.1_Missense_Mutation_p.T267P					nuclear pore complex interacting protein family, member B6									p.T285P(4)									AGACACTCAGTAGGTGTCTTG	0.507000													4	40					0	0	1	0	0
TTC9C	283237	broad.mit.edu	37	11	62502998	62502998	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr11:62502998G>A	ENST00000316461.4	+	2	693	c.383G>A	c.(382-384)cGc>cAc	p.R128H	TTC9C_ENST00000532583.1_Missense_Mutation_p.R128H|TTC9C_ENST00000513247.2_3'UTR	NM_173810.3	NP_776171.1	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	128							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						GACCAGGCCCGCCACTACCTC	0.512000													3	25					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36385001	36385001	+	Silent	SNP	G	G	A	rs144489471	byFrequency	TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr13:36385001G>A	ENST00000255448.4	-	12	1870	c.1659C>T	c.(1657-1659)taC>taT	p.Y553Y	DCLK1_ENST00000379893.1_Silent_p.Y246Y|DCLK1_ENST00000360631.3_Silent_p.Y553Y	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	553	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTGGAGCCACGTATGTTGGGG	0.478000													4	174					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416378	105416378	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr14:105416378G>A	ENST00000333244.5	-	7	5529	c.5410C>T	c.(5410-5412)Cgg>Tgg	p.R1804W	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1804						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCTCCAGCCGCACACTGTCC	0.622000													5	444					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71096155	71096155	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr3:71096155C>T	ENST00000318789.4	-	10	1127	c.602G>A	c.(601-603)cGc>cAc	p.R201H	FOXP1_ENST00000475937.1_Missense_Mutation_p.R201H|FOXP1_ENST00000493089.1_Missense_Mutation_p.R201H|FOXP1_ENST00000491238.1_Missense_Mutation_p.R203H|FOXP1_ENST00000472382.1_5'UTR|FOXP1_ENST00000484350.1_Missense_Mutation_p.R125H|FOXP1_ENST00000468577.1_Missense_Mutation_p.R201H|FOXP1_ENST00000498215.1_Missense_Mutation_p.R201H	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	201	Gln-rich.				cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		AAGGCCTTGGCGCTGCAAAGA	0.527000			T	PAX5	ALL								4	184					0	0	1	0	0
NT5C3A	51251	broad.mit.edu	37	7	33057052	33057052	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr7:33057052G>A	ENST00000409787.1	-	7	603	c.590C>T	c.(589-591)aCt>aTt	p.T197I	NT5C3A_ENST00000409467.1_Splice_Site_p.T185_splice|AVL9_ENST00000404479.1_Intron|NT5C3A_ENST00000396152.2_Splice_Site_p.T197_splice|NT5C3A_ENST00000381626.2_Splice_Site_p.T185_splice|NT5C3A_ENST00000242210.7_Splice_Site_p.T236_splice|NT5C3A_ENST00000405342.1_Splice_Site_p.T197_splice					5'-nucleotidase, cytosolic IIIA																		TATTCTTACAGTTTCATCAAA	0.294000													26	42					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66942312	66942312	+	Silent	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr16:66942312G>A	ENST00000299752.4	-	18	2666	c.2473C>T	c.(2473-2475)Ctg>Ttg	p.L825L	CDH16_ENST00000568632.1_Silent_p.L728L|CDH16_ENST00000394055.3_Silent_p.L803L|CDH16_ENST00000565796.1_Silent_p.L786L|CDH16_ENST00000570262.1_Silent_p.L745L	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	825					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTCGCCTTCAGGGGCACGCTG	0.592000													14	44					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57288930	57288930	+	Missense_Mutation	SNP	G	G	T	rs142667389		TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr17:57288930G>T	ENST00000543872.2	+	2	1782	c.1518G>T	c.(1516-1518)atG>atT	p.M506I	SMG8_ENST00000578922.1_Missense_Mutation_p.M506I|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.M506I|SMG8_ENST00000580498.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	506					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						CTTTACCCATGGCCCACAGTG	0.398000													25	61					3.6726e-16	3.90214e-16	1	1	0
KRI1	65095	broad.mit.edu	37	19	10665833	10665833	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr19:10665833G>A	ENST00000312962.6	-	18	1748	c.1729C>T	c.(1729-1731)Cgg>Tgg	p.R577W	KRI1_ENST00000361821.5_Missense_Mutation_p.R573W	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	577										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CTGTACGCCCGCTTGTCCCGC	0.632000													4	99					0	0	1	0	0
IP6K1	9807	broad.mit.edu	37	3	49775711	49775711	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr3:49775711T>C	ENST00000321599.4	-	3	669	c.368A>G	c.(367-369)cAc>cGc	p.H123R	IP6K1_ENST00000395238.1_5'UTR|IP6K1_ENST00000460540.1_5'UTR|IP6K1_ENST00000468463.1_Missense_Mutation_p.H123R	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	123					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						GCCTGACCGGTGCAGGCTCCG	0.552000													4	55					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128050376	128050376	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr2:128050376T>C	ENST00000493187.2	-	3	552	c.89A>G	c.(88-90)aAa>aGa	p.K30R	ERCC3_ENST00000285398.2_Missense_Mutation_p.K94R			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	94					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TTGGGCATATTTGTAAACTGG	0.473000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				17	43					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	110					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12575498	12575498	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr19:12575498G>A	ENST00000397732.3	-	4	1409	c.1238C>T	c.(1237-1239)aCt>aTt	p.T413I	ZNF709_ENST00000428311.1_Missense_Mutation_p.T413I|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T413I(2)		large_intestine(3)|upper_aerodigestive_tract(3)	6						TCCAGTGTGAGTTCTTTCATG	0.418000													5	150					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033997	52033997	+	Missense_Mutation	SNP	C	C	G			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr19:52033997C>G	ENST00000346477.3	-	3	712	c.644G>C	c.(643-645)tGt>tCt	p.C215S	SIGLEC6_ENST00000436458.1_Missense_Mutation_p.C179S|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.C215S|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.C204S|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.C215S|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.C215S	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	215	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CGTCACCTGACAGGTGAGGTT	0.652000													15	34					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43512971	43512971	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr15:43512971G>A	ENST00000300215.3	-	1	510	c.53C>T	c.(52-54)gCa>gTa	p.A18V	EPB42_ENST00000540029.1_Intron|EPB42_ENST00000441366.2_Intron			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	0					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TGCGGGGGCTGCATACAGTCC	0.582000													4	153					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683180	100683180	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr7:100683180G>A	ENST00000306151.4	+	3	8547	c.8483G>A	c.(8482-8484)gGc>gAc	p.G2828D		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2828	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTGAGGCTGGCACCCTTTCA	0.498000													5	388					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544636	186544636	+	Silent	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr4:186544636G>A	ENST00000431808.1	-	14	2498	c.1935C>T	c.(1933-1935)caC>caT	p.H645H	SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000418609.1_Silent_p.H549H|SORBS2_ENST00000355634.5_Silent_p.H745H|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000284776.7_Silent_p.H645H|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000448662.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	645	His-rich.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.H645H(1)		endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ggtggtggtggtgatggtggt	0.527000													4	63					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520358	33520358	+	Silent	SNP	A	A	G	rs74740601	by1000genomes	TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr17:33520358A>G	ENST00000297307.5	-	1	1054	c.969T>C	c.(967-969)atT>atC	p.I323I		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	323	DUF6 2.					integral to membrane		p.I323I(1)									TCTGGGCTGTAATGATGGCAA	0.547000													4	64					0	0	1	0	0
IGKV1D-16	0	broad.mit.edu	37	2	90139477	90139477	+	RNA	SNP	G	G	A	rs2848291	by1000genomes	TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr2:90139477G>A	ENST00000492446.1	+	0	275																											GTCCCATCAAGGTTCAGCGGC	0.483000													4	178					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114269973	114269973	+	Silent	SNP	A	A	G	rs149757187		TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr7:114269973A>G	ENST00000393500.3	+	11	1105	c.285A>G	c.(283-285)caA>caG	p.Q95Q	FOXP2_ENST00000403559.4_Silent_p.Q187Q|FOXP2_ENST00000393489.3_Silent_p.Q78Q|FOXP2_ENST00000378237.3_Silent_p.Q170Q|FOXP2_ENST00000393491.3_Silent_p.Q78Q|FOXP2_ENST00000393494.2_Silent_p.Q170Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000350908.4_Silent_p.Q170Q|FOXP2_ENST00000390668.3_Silent_p.Q194Q|FOXP2_ENST00000360232.4_Silent_p.Q170Q|FOXP2_ENST00000393498.2_Silent_p.Q150Q|FOXP2_ENST00000408937.3_Silent_p.Q195Q			O15409	FOXP2_HUMAN	forkhead box P2	170	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcagcagcaacaacaacaac	0.502000													4	68					0	0	1	0	0
IL21	59067	broad.mit.edu	37	4	123542015	123542015	+	Missense_Mutation	SNP	T	T	G			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr4:123542015T>G	ENST00000264497.3	-	1	209	c.152A>C	c.(151-153)aAt>aCt	p.N51T	IL21-AS1_ENST00000417927.1_RNA	NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21	44					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						ATTCACATAATTTTTCAGCTG	0.338000													36	47					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	64					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3888472	3888472	+	Missense_Mutation	SNP	G	G	T			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr3:3888472G>T	ENST00000319331.3	+	2	2908	c.2147G>T	c.(2146-2148)tGg>tTg	p.W716L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	716						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TATTACATGTGGTAACTCAGA	0.423000													4	23					0.00024832	0.00024832	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228526563	228526563	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr1:228526563delC	ENST00000570156.2	+	80	20039	c.19965delC	c.(19963-19965)atfs	p.I6655fs	OBSCN_ENST00000366709.4_Frame_Shift_Del_p.I2817fs|OBSCN_ENST00000422127.1_Frame_Shift_Del_p.I5698fs|OBSCN_ENST00000366707.4_Frame_Shift_Del_p.I3332fs|OBSCN_ENST00000284548.11_Frame_Shift_Del_p.I5698fs	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5698	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCTCTGTGATCCAGGAGCTGC	0.672													2	4	---	---	---	---					
AC007682.1	0	broad.mit.edu	37	2	51737448	51737452	+	RNA	DEL	AGGTA	AGGTA	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr2:51737448_51737452delAGGTA	ENST00000440698.1	+	0	694																											GTCCAAGGGTAGGTACCTGAGATGC	0.424													2	4	---	---	---	---					
HHATL	57467	broad.mit.edu	37	3	42741312	42741312	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr3:42741312delC	ENST00000441594.1	-	3	373	c.112delG	c.(112-114)ccfs	p.A38fs	HHATL_ENST00000310417.5_Frame_Shift_Del_p.A38fs	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	38					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TTCCTGTGGGCCCCATCTGAG	0.662													2	4	---	---	---	---					
GRIN1	2902	broad.mit.edu	37	9	140056433	140056433	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr9:140056433delC	ENST00000371561.3	+	11	2622	c.1525delC	c.(1525-1527)agfs	p.Q509fs	GRIN1_ENST00000371560.3_Frame_Shift_Del_p.Q530fs|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000350902.5_Frame_Shift_Del_p.Q509fs|GRIN1_ENST00000371550.4_Frame_Shift_Del_p.Q509fs|GRIN1_ENST00000371553.3_Frame_Shift_Del_p.Q530fs|GRIN1_ENST00000371559.4_Frame_Shift_Del_p.Q509fs|GRIN1_ENST00000371546.4_Frame_Shift_Del_p.Q530fs|GRIN1_ENST00000371555.4_Frame_Shift_Del_p.Q530fs|GRIN1_ENST00000315048.3_Frame_Shift_Del_p.Q509fs	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	509					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCTCAGCGGGCAGGCAGACAT	0.592													2	4	---	---	---	---					
SEC61A2	55176	broad.mit.edu	37	10	12211282	12211282	+	Frame_Shift_Del	DEL	A	A	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr10:12211282delA	ENST00000304267.8	+	12	1357	c.1270delA	c.(1270-1272)agfs	p.K424fs	NUDT5_ENST00000378937.3_Intron|NUDT5_ENST00000491614.1_Intron|NUDT5_ENST00000537776.1_Intron|NUDT5_ENST00000378952.3_Intron|SEC61A2_ENST00000495368.1_3'UTR	NM_001142627.1	NP_001136099.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	0						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				AAGAAGGTGGAAGGGAGAAGG	0.443													2	4	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													3	4	---	---	---	---					
MVD	4597	broad.mit.edu	37	16	88721768	88721768	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WB-A80N-01A-11D-A35I-08	TCGA-WB-A80N-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e276efa-a716-467d-9ef1-aeaae0a1e1af	9ad87214-6a8b-4246-a8b5-151dcef4fbd7	g.chr16:88721768delC	ENST00000301012.3	-	7	765	c.736delG	c.(736-738)agfs	p.E246fs		NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	246					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		AAGTCTCGCTCCCGGATGCAG	0.657													2	4	---	---	---	---					
