Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													6	90					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													5	110					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195599219	195599219	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr3:195599219T>C	ENST00000333602.6	-	10	1996	c.1379A>G	c.(1378-1380)aAc>aGc	p.N460S	TNK2_ENST00000381916.2_Missense_Mutation_p.N523S|TNK2_ENST00000428187.1_Missense_Mutation_p.N492S|TNK2_ENST00000316664.3_Missense_Mutation_p.N460S|TNK2_ENST00000392400.1_Missense_Mutation_p.N460S	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	460	CRIB.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GATGAAGCTGTTCTGCAGGGG	0.657000													3	26					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195692	18195692	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr11:18195692G>A	ENST00000314254.3	+	1	1309	c.889G>A	c.(889-891)Gac>Aac	p.D297N	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	297						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GGCTCTGCAGGACAAGCCTGA	0.552000													4	84					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354569	41354569	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr19:41354569C>T	ENST00000301141.5	-	3	463	c.443G>A	c.(442-444)cGc>cAc	p.R148H	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	148					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CTCCTGGATGCGCTCCTCGAT	0.692000													3	40					0	0	1	0	0
SPTBN1	0	broad.mit.edu	37	2	54853144	54853144	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr2:54853144G>A	ENST00000333896.5	+	11	1763	c.1378G>A	c.(1378-1380)Gca>Aca	p.A460T	SPTBN1_ENST00000356805.4_Missense_Mutation_p.A473T	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	473					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGACATTGCCGCATACGAGGA	0.537000													3	58					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189705336	189705336	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr3:189705336C>T	ENST00000319332.5	-	5	1275	c.1078G>A	c.(1078-1080)Gca>Aca	p.A360T	LEPREL1_ENST00000427335.2_Missense_Mutation_p.A179T	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	360					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCAATGGATGCCGGGTCAATG	0.428000													3	34					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													5	50					1.024e-07	1.09714e-07	1	1	0
TCHHL1	126637	broad.mit.edu	37	1	152058827	152058827	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr1:152058827G>A	ENST00000368806.1	-	3	1395	c.1331C>T	c.(1330-1332)aCa>aTa	p.T444I		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	444							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TAGATATTGTGTCTCAGAACC	0.453000													10	113					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23932274	23932274	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr15:23932274C>T	ENST00000331837.4	-	1	176	c.91G>A	c.(91-93)Ggg>Agg	p.G31R		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	31					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GGAGGAACCCCCTCCGAAACC	0.687000									Prader-Willi syndrome				11	21					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112178930	112178930	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr5:112178930T>C	ENST00000457016.1	+	16	8019	c.7639T>C	c.(7639-7641)Tgg>Cgg	p.W2547R	APC_ENST00000508376.2_Missense_Mutation_p.W2547R|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.W2547R			P25054	APC_HUMAN	adenomatous polyposis coli	2547	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GTCAGGAACCTGGAAACGTGA	0.428000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			4	71					0	0	1	0	0
SLC35G2	80723	broad.mit.edu	37	3	136573458	136573458	+	Silent	SNP	T	T	C			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr3:136573458T>C	ENST00000446465.2	+	2	784	c.156T>C	c.(154-156)aaT>aaC	p.N52N	SLC35G2_ENST00000393079.3_Silent_p.N52N|RP11-85F14.5_ENST00000461864.1_RNA|RP11-85F14.5_ENST00000474250.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	52						Golgi apparatus|integral to membrane											TGGAGGAAAATCCAAAGAAAG	0.408000													46	91					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44221299	44221299	+	Silent	SNP	C	C	T	rs143048794	byFrequency	TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr6:44221299C>T	ENST00000371554.1	+	12	2353	c.2139C>T	c.(2137-2139)ggC>ggT	p.G713G	HSP90AB1_ENST00000371646.5_Silent_p.G713G|HSP90AB1_ENST00000353801.3_Silent_p.G713G			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	713					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.G713G(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTCTCGAGGGCGATGAGGATG	0.498000											OREG0017471	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	35					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			38	36					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53516319	53516319	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr1:53516319G>A	ENST00000371514.3	+	16	1755	c.1587G>A	c.(1585-1587)atG>atA	p.M529I	SCP2_ENST00000407246.2_Missense_Mutation_p.M505I|SCP2_ENST00000435345.2_Missense_Mutation_p.M125I|SCP2_ENST00000430330.2_Missense_Mutation_p.M122I|SCP2_ENST00000408941.3_3'UTR|SCP2_ENST00000371509.4_Missense_Mutation_p.M485I|SCP2_ENST00000528311.1_Missense_Mutation_p.M448I|SCP2_ENST00000488965.1_3'UTR	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	529	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						CTGGCAACATGGGTCTCGCTA	0.373000													5	41					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	52					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17085364	17085364	+	RNA	SNP	G	G	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr1:17085364G>A	ENST00000455405.2	-	0	3																											CAGGGCCCATGGCTATCCCCA	0.597000													3	22					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178919203	178919203	+	Silent	SNP	C	C	A			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr3:178919203C>A	ENST00000263967.3	+	4	845	c.688C>A	c.(688-690)Cga>Aga	p.R230R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	230	PI3K-RBD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAAAAAACTCGAAGTATGTT	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	34					1.99824e-07	2.06714e-07	1	1	0
KRT6C	286887	broad.mit.edu	37	12	52863523	52863523	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr12:52863523A>G	ENST00000252250.6	-	7	1402	c.1355T>C	c.(1354-1356)aTg>aCg	p.M452T		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	452	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		CTTGACATTCATCAGCTCCTG	0.597000													18	62					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118372559	118372559	+	Silent	SNP	G	G	A	rs145452548	by1000genomes	TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr11:118372559G>A	ENST00000534358.1	+	26	6515	c.6492G>A	c.(6490-6492)ccG>ccA	p.P2164P	KMT2A_ENST00000389506.5_Silent_p.P2161P|KMT2A_ENST00000354520.4_Silent_p.P2123P	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GCTGTCGACCGTTGCCTTCTG	0.443000													4	86					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	52					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23728528	23728528	+	Silent	SNP	C	C	T			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr20:23728528C>T	ENST00000304749.2	-	3	421	c.351G>A	c.(349-351)ttG>ttA	p.L117L	CST1_ENST00000398402.1_Silent_p.L117L	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	117						extracellular region	cysteine-type endopeptidase inhibitor activity	p.L117L(1)		kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CGAAAGAGCACAACTGTTTCT	0.527000													3	25					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41149523	41149523	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr5:41149523C>T	ENST00000263413.3	-	17	2707	c.2443G>A	c.(2443-2445)Gct>Act	p.A815T	C6_ENST00000337836.5_Missense_Mutation_p.A815T	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	815	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AACTTACAAGCGGGTGAAGTA	0.418000													5	143					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	832030	832030	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr16:832030delG	ENST00000293892.3	-	2	92	c.93delC	c.(91-93)ccfs	p.P31fs	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						GGAAGGTGCTGGGGCCAAGGG	0.662													2	4	---	---	---	---					
USP14	9097	broad.mit.edu	37	18	158712	158712	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WB-A80O-01A-11D-A35I-08	TCGA-WB-A80O-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e09d3fb-45c2-42a5-a7e7-5f4dd76f7a92	8170c6e0-56f4-4b2d-97c0-fce7f75ec117	g.chr18:158712delC	ENST00000261601.6	+	1	105	c.14delC	c.(13-15)tcfs	p.S5fs	USP14_ENST00000383589.2_Frame_Shift_Del_p.S5fs|USP14_ENST00000582707.1_Frame_Shift_Del_p.S5fs|USP14_ENST00000400266.3_Frame_Shift_Del_p.S5fs	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	5	Ubiquitin-like.				regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CCGCTCTACTCCGGTGAGCCC	0.766													2	4	---	---	---	---					
