Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LANCL1	10314	broad.mit.edu	37	2	211302429	211302429	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr2:211302429G>A	ENST00000443314.1	-	6	1200	c.858C>T	c.(856-858)ctC>ctT	p.L286L	LANCL1_ENST00000441020.3_Silent_p.L286L|LANCL1_ENST00000233714.4_Silent_p.L286L|LANCL1_ENST00000431941.2_Silent_p.L286L|AC007970.1_ENST00000433296.1_RNA|LANCL1_ENST00000450366.2_Silent_p.L286L|AC007970.1_ENST00000420418.1_RNA			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	286						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		AGGCCTGGATGAGCATGTAGA	0.358000													5	37					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	91					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213415627	213415627	+	Missense_Mutation	SNP	A	A	T			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr1:213415627A>T	ENST00000366960.3	+	11	2958	c.2808A>T	c.(2806-2808)ttA>ttT	p.L936F	RPS6KC1_ENST00000543470.1_Missense_Mutation_p.L724F|RPS6KC1_ENST00000543354.1_Missense_Mutation_p.L639F|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.L924F|RPS6KC1_ENST00000490299.1_3'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	936	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		ACAACATCTTATTGAATGATA	0.398000													14	119					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q|TBC1D2B_ENST00000492078.1_5'UTR			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													3	13					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	122					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811108	140811108	+	Silent	SNP	C	C	T			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr4:140811108C>T	ENST00000509479.2	-	2	2338	c.1482G>A	c.(1480-1482)caG>caA	p.Q494Q	MAML3_ENST00000327122.5_Silent_p.Q338Q|MAML3_ENST00000398940.1_Silent_p.Q33Q	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	494	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.537000													4	20					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75066839	75066839	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr7:75066839C>T	ENST00000453279.2	-	7	1298	c.434G>A	c.(433-435)cGc>cAc	p.R145H	POM121C_ENST00000257665.5_Missense_Mutation_p.R387H	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	387	Pore side (Potential).|Pro-rich.|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						AATGGCATTGCGGCTGGAGCT	0.502000													4	174					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	12					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890365	55890365	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr11:55890365A>G	ENST00000313472.3	+	1	517	c.517A>G	c.(517-519)Ata>Gta	p.I173V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TGACTCAAACATAATTCATCA	0.438000													4	228					0	0	1	0	0
DLX4	0	broad.mit.edu	37	17	48046950	48046950	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr17:48046950G>A	ENST00000240306.3	+	1	413	c.118G>A	c.(118-120)Gca>Aca	p.A40T	DLX4_ENST00000503410.1_Intron|DLX4_ENST00000505318.2_Missense_Mutation_p.A40T	NM_138281.2	NP_612138.1	Q92988	DLX4_HUMAN	distal-less homeobox 4	40				MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAA SPNLSYSRPYGHLLSYPYTEPANPGDSYLSCQQPAALSQPL CGPAEHPQELEA -> GGSLSLPPEPLCARCPTKEGAAPRR PGFWGSLETQAATVWRGRHGHFSCRVRLSRGAARYSRRGQG KPGVTISAARLVFKVLSAGPLTHPAGRSRRLPRGHRLKPLS IALSLCLQCPSSVISRPRLSPGPSLSAPPYPKLAPPPVAEL RPPTAGAAVPWLWPSARFLPRVTGPIRVGAPLGAELRLVSP GAVNVGVETLHAE (in Ref. 9).	multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(3)	10						CCCTACAACCGCAGCCTCCCC	0.662000													4	135					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31137681	31137681	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr10:31137681G>A	ENST00000538351.1	-	7	2260	c.1506C>T	c.(1504-1506)agC>agT	p.S502S	ZNF438_ENST00000436087.2_Silent_p.S551S|ZNF438_ENST00000375311.1_Silent_p.S115S|ZNF438_ENST00000413025.1_Silent_p.S551S|ZNF438_ENST00000331737.6_Silent_p.S541S|ZNF438_ENST00000452305.1_Silent_p.S541S|ZNF438_ENST00000444692.2_Silent_p.S541S|ZNF438_ENST00000361310.3_Silent_p.S551S|ZNF438_ENST00000442986.1_Silent_p.S551S	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TCATGTGTGTGCTCAGGCTGC	0.473000													5	214					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	56					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72081809	72081809	+	RNA	SNP	T	T	C			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr7:72081809T>C	ENST00000438125.1	-	0	1246							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GAACTTTCTCTGCAGTAGGTA	0.498000													4	51					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62597735	62597735	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr20:62597735G>A	ENST00000450537.1	-	5	853	c.793C>T	c.(793-795)Ccg>Tcg	p.P265S	ZNF512B_ENST00000369888.1_Missense_Mutation_p.P265S|ZNF512B_ENST00000217130.3_Missense_Mutation_p.P265S			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TTGGTGACCGGCACAGACTTG	0.572000													6	438					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269120	1269120	+	Missense_Mutation	SNP	C	C	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr11:1269120C>A	ENST00000447027.1	+	31	11077	c.11019C>A	c.(11017-11019)caC>caA	p.H3673Q	MUC5B_ENST00000529681.1_Missense_Mutation_p.H3670Q|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3670	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTACGGCCACTGCCCCAGCA	0.597000													12	116					7.93312e-07	8.16645e-07	1	1	0
HS3ST3B1	9953	broad.mit.edu	37	17	14204904	14204904	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr17:14204904G>A	ENST00000360954.2	+	1	505	c.69G>A	c.(67-69)ccG>ccA	p.P23P		NM_006041.1	NP_006032.1	Q9Y662	HS3SB_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	23					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			large_intestine(3)|lung(3)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CGCAgccgccgccgcccccgc	0.726000													3	4					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	75					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275374	71275374	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr4:71275374G>A	ENST00000399575.2	+	3	503	c.329G>A	c.(328-330)aGa>aAa	p.R110K	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	110	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TTCCCACTAAGACCTTACTAT	0.403000													20	195					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152472814	152472814	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr6:152472814G>A	ENST00000367255.5	-	135	24925	c.24324C>T	c.(24322-24324)ggC>ggT	p.G8108G	SYNE1_ENST00000354674.4_Silent_p.G263G|SYNE1_ENST00000423061.1_Silent_p.G8037G|SYNE1_ENST00000356820.4_Silent_p.G2632G|SYNE1_ENST00000265368.4_Silent_p.G8108G|SYNE1_ENST00000341594.5_Silent_p.G7720G|SYNE1_ENST00000539504.1_Silent_p.G263G|SYNE1_ENST00000448038.1_Silent_p.G8037G|SYNE1_ENST00000347037.5_5'UTR	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8108					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTCACGCTGGCCAATAAAAT	0.428000										HNSCC(10;0.0054)			7	28					0	0	1	0	0
TMEM144	55314	broad.mit.edu	37	4	159158779	159158779	+	Silent	SNP	A	A	G			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr4:159158779A>G	ENST00000296529.6	+	9	1186	c.666A>G	c.(664-666)gcA>gcG	p.A222A	TMEM144_ENST00000503404.1_3'UTR	NM_018342.4	NP_060812.2	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	222						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(7)|lung(9)|prostate(1)	19	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		GTATATATGCAGGGGCAAGCC	0.323000													10	38					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34935028	34935028	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr6:34935028G>A	ENST00000360359.3	+	2	348	c.210G>A	c.(208-210)ggG>ggA	p.G70G	ANKS1A_ENST00000535627.1_Silent_p.G70G	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	70						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TGTGGAGAGGGCCAAATGTGA	0.423000													4	121					0	0	1	0	0
GPX4	2879	broad.mit.edu	37	19	1105248	1105248	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr19:1105248G>A	ENST00000354171.8	+	2	255	c.148G>A	c.(148-150)Gac>Aac	p.D50N	GPX4_ENST00000589115.1_Missense_Mutation_p.D50N	NM_001039847.1|NM_002085.3	NP_001034936.1|NP_002076.2	P36969	GPX4_HUMAN	glutathione peroxidase 4	50					multicellular organismal development|phospholipid metabolic process		glutathione peroxidase activity|phospholipid-hydroperoxide glutathione peroxidase activity			endometrium(1)|kidney(2)	3		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glutathione(DB00143)	CAAGGACATCGACGGGCACAT	0.682000													14	83					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	56					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78443848	78443848	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr12:78443848T>C	ENST00000397909.2	+	10	2272	c.2099T>C	c.(2098-2100)aTg>aCg	p.M700T	NAV3_ENST00000228327.6_Missense_Mutation_p.M700T|NAV3_ENST00000536525.2_Missense_Mutation_p.M700T|NAV3_ENST00000266692.7_Missense_Mutation_p.M700T			Q8IVL0	NAV3_HUMAN	neuron navigator 3	700						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GAAGAGACTATGTCCAGTCTT	0.328000										HNSCC(70;0.22)			5	39					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000403	16000403	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr19:16000403T>C	ENST00000221700.5	-	7	843	c.748A>G	c.(748-750)Acc>Gcc	p.T250A	CYP4F2_ENST00000011989.7_Missense_Mutation_p.T101A|CYP4F2_ENST00000592328.1_Missense_Mutation_p.T250A	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	250					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CCATCAGGGGTGAGATAATAC	0.557000													33	82					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111853098	111853098	+	Silent	SNP	G	G	A			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr11:111853098G>A	ENST00000440460.2	+	7	1101	c.804G>A	c.(802-804)cgG>cgA	p.R268R	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Silent_p.R57R	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	268	Actin-binding.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GAGACTGGCGGCCAGGGAGCC	0.423000											OREG0021331	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	26					0	0	1	0	0
RP11-206L10.10	0	broad.mit.edu	37	1	745643	745643	+	RNA	DEL	C	C	-			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr1:745643delC	ENST00000435300.1	-	0	340																											TTCAAAGTGACAGACTGTGGG	0.299													5	3	---	---	---	---					
RTN4	57142	broad.mit.edu	37	2	55252907	55252910	+	Frame_Shift_Del	DEL	AAAT	AAAT	-			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr2:55252907_55252910delAAAT	ENST00000337526.6	-	3	2568_2571	c.2325_2328delATTT	c.(2323-2328)tcfs	p.SF775fs	RTN4_ENST00000357732.4_Intron|RTN4_ENST00000404909.1_Frame_Shift_Del_p.SF569fs|RTN4_ENST00000357376.3_Frame_Shift_Del_p.SF569fs|RTN4_ENST00000394611.2_Frame_Shift_Del_p.SF569fs|RTN4_ENST00000354474.6_Frame_Shift_Del_p.SF543fs|RTN4_ENST00000405240.1_Frame_Shift_Del_p.SF569fs|RTN4_ENST00000317610.7_Intron|RTN4_ENST00000402434.2_Intron	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	775					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						TCATTGACTCAAATGAAGTCTCAG	0.363													24	89	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172992494	172992494	+	RNA	DEL	C	C	-	rs79222726		TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr3:172992494delC	ENST00000447709.1	+	0	216																											aacaaacaaacaaaaacatgt	0.512													4	4	---	---	---	---					
NFE2L3	9603	broad.mit.edu	37	7	26224911	26224914	+	Frame_Shift_Del	DEL	AGAT	AGAT	-			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr7:26224911_26224914delAGAT	ENST00000056233.3	+	4	1852_1855	c.1593_1596delAGAT	c.(1591-1596)acfs	p.TD531fs		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	531					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						TTGAAGACACAGATAGAAACTTGA	0.431													31	85	---	---	---	---					
FAM66B	0	broad.mit.edu	37	8	7191540	7191541	+	RNA	DEL	CA	CA	-			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr8:7191540_7191541delCA	ENST00000606573.1	-	0	703																											GGGGTGcacgcacacacacaca	0.530													8	41	---	---	---	---					
EBLN1	340900	broad.mit.edu	37	10	22498484	22498485	+	In_Frame_Ins	INS	-	-	AGA	rs145490621	by1000genomes	TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr10:22498484_22498485insAGA	ENST00000422359.2	-	1	465_466	c.428_429insTCT	c.(427-429)cat>cTCTat	p.143_143H>LY		NM_001199938.1	NP_001186867.1			endogenous Bornavirus-like nucleoprotein 1																		CAATGCCTATCAGATCACAGCA	0.455													4	2	---	---	---	---					
TRAV9-2	0	broad.mit.edu	37	14	22409533	22409537	+	RNA	DEL	CTCTC	CTCTC	-	rs57759840		TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr14:22409533_22409537delCTCTC	ENST00000390441.2	+	0	102																											ctctctctctctctctctTTTTTTT	0.410													4	9	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-WB-A81H-01A-11D-A35I-08	TCGA-WB-A81H-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2759a8f9-f3d1-4883-9ce4-ba235595c426	705edc68-43ca-465d-894e-1d6d39ab9d9f	g.chr16:69782978_69782980delTCC	ENST00000268802.5	-	6	596_598	c.567_569delGGA	c.(565-570)gaa>ga	p.EE189del		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	189	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCGTTTTCTTCCTCCTCCTCCT	0.522													7	83	---	---	---	---					
