Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C14orf159	80017	broad.mit.edu	37	14	91639743	91639743	+	Silent	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr14:91639743C>T	ENST00000518868.1	+	9	1257	c.567C>T	c.(565-567)ctC>ctT	p.L189L	C14orf159_ENST00000523771.1_Silent_p.L184L|C14orf159_ENST00000525393.2_Silent_p.L60L|C14orf159_ENST00000523816.1_Silent_p.L184L|C14orf159_ENST00000428926.2_Silent_p.L184L|C14orf159_ENST00000412671.2_Silent_p.L189L|C14orf159_ENST00000522322.1_Silent_p.L184L|C14orf159_ENST00000256324.10_Silent_p.L189L|C14orf159_ENST00000521077.2_Silent_p.L189L|C14orf159_ENST00000520328.1_Silent_p.L184L			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	184						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GCTGCTCCCTCGGAGGTGAGC	0.612000											OREG0022869	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	21					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22657646	22657646	+	RNA	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr22:22657646C>T	ENST00000426066.1	+	0	58					NR_027293.1																						AAGGGAAAATCGGGCCCCGAT	0.507000													4	22					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141730215	141730215	+	Silent	SNP	T	T	C			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr7:141730215T>C	ENST00000475668.2	+	11	1329	c.1275T>C	c.(1273-1275)taT>taC	p.Y425Y	MGAM_ENST00000549489.2_Silent_p.Y425Y			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	425	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACTTCACTTATGATTCAGTGG	0.383000													18	17					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			21	28					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28320051	28320051	+	Missense_Mutation	SNP	T	T	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr1:28320051T>A	ENST00000373871.3	-	14	1403	c.1163A>T	c.(1162-1164)gAt>gTt	p.D388V	EYA3_ENST00000373863.3_Missense_Mutation_p.D342V|EYA3_ENST00000373864.1_Missense_Mutation_p.D231V|EYA3_ENST00000545175.1_Missense_Mutation_p.D335V|EYA3_ENST00000540618.1_Missense_Mutation_p.D342V|EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000436342.2_Missense_Mutation_p.D262V			Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	388				D -> N (in Ref. 1; CAA71311).	anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		ACTGAAACCATCTGTTGAGAA	0.428000													24	22					0	0	1	0	0
BZW1	9689	broad.mit.edu	37	2	201686894	201686894	+	Missense_Mutation	SNP	G	G	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr2:201686894G>T	ENST00000409600.1	+	12	1708	c.1253G>T	c.(1252-1254)gGt>gTt	p.G418V	BZW1_ENST00000409226.1_Missense_Mutation_p.G422V|BZW1_ENST00000452790.2_Missense_Mutation_p.G450V	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						GCTGAAGAAGGTGACTGAATT	0.373000													4	18					1.23904e-05	1.27081e-05	1	1	0
ANK3	288	broad.mit.edu	37	10	61829127	61829127	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr10:61829127G>A	ENST00000280772.1	-	37	11703	c.11512C>T	c.(11512-11514)Cac>Tac	p.H3838Y	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3838					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTTACACAGTGTCCTTGTAGT	0.398000													55	138					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	125032328	125032328	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr3:125032328G>A	ENST00000360647.4	-	4	642	c.157C>T	c.(157-159)Cct>Tct	p.P53S	ZNF148_ENST00000492394.1_Missense_Mutation_p.P53S|ZNF148_ENST00000485866.1_Missense_Mutation_p.P53S|ZNF148_ENST00000484491.1_Missense_Mutation_p.P53S|ZNF148_ENST00000468369.1_Intron|ZNF148_ENST00000544464.1_Intron	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	53					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						TCCTGGTGAGGCATACTTCGA	0.453000													4	76					0	0	1	0	0
TMEM98	26022	broad.mit.edu	37	17	31260234	31260234	+	Silent	SNP	G	G	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr17:31260234G>A	ENST00000579849.1	+	4	605	c.174G>A	c.(172-174)gaG>gaA	p.E58E	TMEM98_ENST00000394642.3_Silent_p.E58E|TMEM98_ENST00000578289.1_Silent_p.E58E	NM_015544.2	NP_056359.2	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	58						endoplasmic reticulum|integral to membrane				kidney(2)|large_intestine(1)	3		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			CCCAGTCTGAGCCCTCTGAGT	0.532000													17	33					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683256	50683256	+	Missense_Mutation	SNP	T	T	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr6:50683256T>A	ENST00000008391.3	+	2	695	c.467T>A	c.(466-468)aTg>aAg	p.M156K		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	156							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CAGTATGGAATGCACCCAGAT	0.617000													49	53					0	0	1	0	0
HSPA1L	0	broad.mit.edu	37	6	31779452	31779452	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr6:31779452C>T	ENST00000375654.4	-	2	487	c.298G>A	c.(298-300)Gga>Aga	p.G100R	HSPA1L_ENST00000417199.3_Missense_Mutation_p.G100R	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	100					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GGCTTGCCTCCTTCATTAATC	0.413000													4	121					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	29					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62039370	62039370	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr10:62039370C>T	ENST00000280772.1	-	2	333	c.142G>A	c.(142-144)Gca>Aca	p.A48T	ANK3_ENST00000503366.1_Missense_Mutation_p.A31T|ANK3_ENST00000373827.2_Missense_Mutation_p.A42T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	48					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTCGAGCTGCTCTTAAGTAA	0.343000													37	71					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11995945	11995945	+	Silent	SNP	G	G	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr8:11995945G>A	ENST00000333796.3	-	1	641	c.325C>T	c.(325-327)Ctg>Ttg	p.L109L	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	109					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						TCCCGGGACAGCATGTAGTTG	0.567000													17	41					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57642487	57642487	+	Splice_Site	SNP	A	A	C			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr12:57642487A>C	ENST00000332782.2	-	4	634		c.e4+1		STAC3_ENST00000546246.2_Intron|STAC3_ENST00000554578.1_Splice_Site	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3						intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CAGCCTACTCACGATCTTGCC	0.542000													9	405					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94223489	94223489	+	Splice_Site	SNP	T	T	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr10:94223489T>A	ENST00000265986.6	-	21	2816	c.2761_splice	c.e21+1	p.R920_splice	IDE_ENST00000496903.1_5'UTR|IDE_ENST00000371581.5_Splice_Site_p.R365_splice	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	920					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTACCTTACCTCTGTCAAAAT	0.373000													9	110					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124530814	124530814	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr9:124530814C>T	ENST00000408936.3	+	10	1983	c.1801C>T	c.(1801-1803)Ctc>Ttc	p.L601F	DAB2IP_ENST00000309989.1_Missense_Mutation_p.L477F|DAB2IP_ENST00000259371.2_Missense_Mutation_p.L573F			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	601					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CCCCGAGACCCTCTCCAATAC	0.597000													68	33					0	0	1	0	0
VSIG4	11326	broad.mit.edu	37	X	65253674	65253674	+	Splice_Site	SNP	T	T	C			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chrX:65253674T>C	ENST00000455586.2	-	2	182		c.e2-2		VSIG4_ENST00000412866.2_Splice_Site|VSIG4_ENST00000374737.4_Splice_Site	NM_001184830.1	NP_001171759.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4						complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGGACGGCCTGAAGAGGCGG	0.512000													10	8					0	0	1	0	0
RAB6A	5870	broad.mit.edu	37	11	73388973	73388973	+	Silent	SNP	T	T	C			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr11:73388973T>C	ENST00000310653.6	-	8	1098	c.597A>G	c.(595-597)caA>caG	p.Q199Q	RAB6A_ENST00000336083.3_Silent_p.Q199Q|RAB6A_ENST00000536566.1_Silent_p.Q166Q|RAB6A_ENST00000541588.1_Silent_p.Q95Q	NM_001077637.1|NM_002869.4	NP_001071105.1|NP_002860.2	P20340	RAB6A_HUMAN	RAB6A, member RAS oncogene family	199					minus-end-directed organelle transport along microtubule|peptidyl-cysteine methylation|protein targeting to Golgi|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic vesicle|cytosol|Golgi membrane|trans-Golgi network	GTP binding|GTPase activity|protein domain specific binding			large_intestine(2)|lung(2)	4						CACTGACTGGTTGCTCCTGAG	0.418000													4	77					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													3	36					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89926980	89926980	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr6:89926980G>A	ENST00000435811.1	-	1	516	c.62C>T	c.(61-63)gCc>gTc	p.A21V	GABRR1_ENST00000454853.2_Missense_Mutation_p.A21V|GABRR1_ENST00000369451.3_Intron|GABRR1_ENST00000481493.1_5'UTR	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	21					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GCTTTCAGTGGCCAAAACCCA	0.463000													3	34					0	0	1	0	0
VPS37A	137492	broad.mit.edu	37	8	17123483	17123483	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr8:17123483A>G	ENST00000324849.4	+	2	867	c.193A>G	c.(193-195)Att>Gtt	p.I65V	VPS37A_ENST00000521829.1_Intron|VPS37A_ENST00000324815.3_Missense_Mutation_p.I65V	NM_001145152.1|NM_152415.2	NP_001138624.1|NP_689628.2	Q8NEZ2	VP37A_HUMAN	vacuolar protein sorting 37 homolog A (S. cerevisiae)	65					cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus				autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	10				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		GACAATTAACATTAATATGTG	0.284000													10	72					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74443772	74443772	+	Missense_Mutation	SNP	C	C	T	rs139908030	byFrequency	TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr16:74443772C>T	ENST00000339953.5	-	11	1337	c.1216G>A	c.(1216-1218)Gtg>Atg	p.V406M		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	406	C-type lectin.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CTCAGCCACACCAGCCTGTGG	0.627000													4	38					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	38					0	0	1	0	0
MCUR1	63933	broad.mit.edu	37	6	13794127	13794127	+	Splice_Site	SNP	A	A	G			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr6:13794127A>G	ENST00000379170.4	-	7	1046	c.909_splice	c.e7+1	p.L303_splice		NM_001031713.3	NP_001026883.1			mitochondrial calcium uniporter regulator 1																		GTTTCTTACCAATGCCACTAT	0.373000													11	31					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P|FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													5	132					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4446365	4446365	+	Missense_Mutation	SNP	C	C	A			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr19:4446365C>A	ENST00000301281.6	-	9	1090	c.966G>T	c.(964-966)atG>atT	p.M322I	UBXN6_ENST00000394765.3_Missense_Mutation_p.M269I	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	322						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						CCTTCTCCCGCATGGCCTTGG	0.711000													3	6					6.4e-05	6.4e-05	1	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074470	76074470	+	RNA	SNP	A	A	G			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr15:76074470A>G	ENST00000395215.3	+	0	649																		p.Q203R(4)									CGGTTACAGCAGACCATAAAG	0.577000													6	43					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71054178	71054178	+	Missense_Mutation	SNP	T	T	C	rs117718337		TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr16:71054178T>C	ENST00000393567.2	-	22	3379	c.3229A>G	c.(3229-3231)Ata>Gta	p.I1077V	HYDIN_ENST00000448089.2_Missense_Mutation_p.I1029V	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1077			I -> V (in dbSNP:rs6416709).					p.I1077V(3)|p.I1029V(3)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATGTTCTTTATGGCCAAGGGC	0.418000													3	39					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157100396	157100397	+	In_Frame_Ins	INS	-	-	CGC			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr6:157100396_157100397insCGC	ENST00000346085.5	+	1	1334_1335	c.1333_1334insCGC	c.(1333-1335)gcc>CGCgcc	p.444_445insR	ARID1B_ENST00000367148.1_In_Frame_Ins_p.444_445insR|ARID1B_ENST00000350026.5_In_Frame_Ins_p.444_445insR|ARID1B_ENST00000275248.4_In_Frame_Ins_p.386_387insR	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	444	Ala-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity	p.P392_S393insP(1)		NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGCCCCAGCGCGCCGCCGCCG	0.787													4	5	---	---	---	---					
TPM2	7169	broad.mit.edu	37	9	35683161	35683161	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A81T-01A-11D-A35I-08	TCGA-WB-A81T-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	556c1156-ed29-43ee-a71e-53c24c51bed2	0c820458-5d04-4ba4-ba51-7a3e58fdd3fb	g.chr9:35683161delG	ENST00000360958.2	-	9	954	c.850delC	c.(850-852)tcfs	p.L284fs	TPM2_ENST00000378300.5_Intron|TPM2_ENST00000329305.2_Intron|TPM2_ENST00000378292.3_Intron	NM_003289.3	NP_003280.2	P07951	TPM2_HUMAN	tropomyosin 2 (beta)	284					muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGGGCTCAGAGGGAGGTGATG	0.577													2	4	---	---	---	---					
