Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample
EPHB2	2048	broad.mit.edu	37	1	23111211	23111211	+	Silent	SNP	C	C	T			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr1:23111211C>T	ENST00000400191.3	+	3	471	c.453C>T	c.(451-453)gaC>gaT	p.D151D	EPHB2_ENST00000544305.1_Silent_p.D151D|EPHB2_ENST00000374632.3_Silent_p.D151D|EPHB2_ENST00000374627.1_Silent_p.D145D|EPHB2_ENST00000374630.3_Silent_p.D151D	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	151					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCCAGGTGGACCTGGGTGGCC	0.597													12	11	---	---	---	---
RPRD2	23248	broad.mit.edu	37	1	150444279	150444279	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr1:150444279C>G	ENST00000401000.4	+	10	2842	c.2777C>G	c.(2776-2778)aCt>aGt	p.T926S	RPRD2_ENST00000369068.4_Missense_Mutation_p.T952S|RPRD2_ENST00000539519.1_Intron|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	952	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CAATCTACCACTGGGCATCTC	0.527													128	134	---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22389479	22389479	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr4:22389479A>G	ENST00000334304.5	-	19	4084	c.3815T>C	c.(3814-3816)gTt>gCt	p.V1272A	GPR125_ENST00000282943.5_5'UTR	NM_145290.3	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1272					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TTCAAGTTCAACCACAGCTGG	0.438													14	21	---	---	---	---
PDE10A	10846	broad.mit.edu	37	6	165829699	165829699	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr6:165829699A>T	ENST00000366882.1	-	13	1193	c.1039T>A	c.(1039-1041)Tat>Aat	p.Y347N	PDE10A_ENST00000539869.2_Missense_Mutation_p.Y357N|PDE10A_ENST00000354448.4_Missense_Mutation_p.Y347N			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	347	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGGTCTGCATAGGCATCTGGA	0.448													48	66	---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48318265	48318265	+	Silent	SNP	C	C	T			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr7:48318265C>T	ENST00000435803.1	+	18	7498	c.7474C>T	c.(7474-7476)Ctg>Ttg	p.L2492L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2492					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AAGTCACGTCCTGAAACCCCT	0.398													6	205	---	---	---	---
ZNF398	57541	broad.mit.edu	37	7	148851149	148851149	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr7:148851149T>C	ENST00000475153.1	+	2	404	c.137T>C	c.(136-138)gTg>gCg	p.V46A	ZNF398_ENST00000420008.2_5'UTR|ZNF398_ENST00000483892.1_5'UTR|ZNF398_ENST00000335901.4_5'UTR|ZNF398_ENST00000426851.2_5'UTR|ZNF398_ENST00000540950.1_Missense_Mutation_p.V51A|ZNF398_ENST00000491174.1_5'UTR|ZNF398_ENST00000485111.1_3'UTR			Q8TD17	ZN398_HUMAN	zinc finger protein 398	46					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			CTGTGGACAGTGGTGGCCGCC	0.592													37	23	---	---	---	---
PNOC	5368	broad.mit.edu	37	8	28186778	28186778	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr8:28186778C>A	ENST00000301908.3	+	2	312	c.104C>A	c.(103-105)gCc>gAc	p.A35D	RP11-380I10.4_ENST00000521731.1_RNA	NM_006228.3	NP_006219.1	Q13519	PNOC_HUMAN	prepronociceptin	35					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	5		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		CTCCACCCAGCCCTGGACAGC	0.577													3	23	---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96420442	96420442	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr9:96420442G>C	ENST00000359246.4	+	10	1530	c.1163G>C	c.(1162-1164)gGg>gCg	p.G388A	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	388					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CACAAATCTGGGAAGCAGCTG	0.567													19	19	---	---	---	---
NUTM2A	728118	broad.mit.edu	37	10	88988143	88988143	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr10:88988143G>A	ENST00000381689.4	+	2	837	c.506G>A	c.(505-507)gGg>gAg	p.G169E	NUTM2A-AS1_ENST00000451940.2_RNA|NUTM2A_ENST00000381707.2_Missense_Mutation_p.G169E					NUT family member 2A																		GTGACTGCAGGGGCTCCTCCA	0.687													12	38	---	---	---	---
EXT2	2132	broad.mit.edu	37	11	44146380	44146380	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr11:44146380A>C	ENST00000395673.3	+	5	940	c.884A>C	c.(883-885)cAt>cCt	p.H295P	EXT2_ENST00000343631.3_Missense_Mutation_p.H262P|EXT2_ENST00000533608.1_Missense_Mutation_p.H262P|EXT2_ENST00000358681.4_Missense_Mutation_p.H262P	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	262					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTGGGTCTCCATCCTGAGTAC	0.473			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				14	2	---	---	---	---
C12orf10	60314	broad.mit.edu	37	12	53693739	53693739	+	Splice_Site	SNP	T	T	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr12:53693739T>C	ENST00000267103.5	+	1	268		c.e1+2		C12orf10_ENST00000548632.1_Splice_Site|RP11-680A11.5_ENST00000550263.1_RNA	NM_021640.3	NP_067653	Q86UA3	Q86UA3_HUMAN	chromosome 12 open reading frame 10											cervix(1)|endometrium(3)|kidney(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	20						GAGTACCGGGTACGGTCCGCG	0.647											OREG0021864	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	15	---	---	---	---
TCTN2	79867	broad.mit.edu	37	12	124163788	124163788	+	Silent	SNP	T	T	G			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr12:124163788T>G	ENST00000303372.5	+	5	644	c.516T>G	c.(514-516)ccT>ccG	p.P172P	TCTN2_ENST00000426174.2_Silent_p.P171P	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	172	Cys-rich.				cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		GCCCTTGTCCTTGTAATTTAA	0.448													39	4	---	---	---	---
ISM2	145501	broad.mit.edu	37	14	77950790	77950790	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr14:77950790G>A	ENST00000393684.3	-	4	630	c.239C>T	c.(238-240)gCa>gTa	p.A80V	ISM2_ENST00000493585.1_Missense_Mutation_p.A168V|ISM2_ENST00000342219.4_Missense_Mutation_p.A168V|ISM2_ENST00000412904.1_Intron|ISM2_ENST00000429906.1_Missense_Mutation_p.A87V			Q6H9L7	ISM2_HUMAN	isthmin 2	168						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						GGTCAGGGCTGCTGGCTCAGT	0.612													28	39	---	---	---	---
BLM	641	broad.mit.edu	37	15	91346839	91346839	+	Silent	SNP	G	G	A			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr15:91346839G>A	ENST00000355112.3	+	18	3565	c.3447G>A	c.(3445-3447)ctG>ctA	p.L1149L	BLM_ENST00000560509.1_Intron|BLM_ENST00000560136.1_3'UTR	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	1149					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TTAAAAAGCTGATACTTGACA	0.378			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				21	71	---	---	---	---
SPOP	8405	broad.mit.edu	37	17	47696426	47696426	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr17:47696426A>C	ENST00000393331.3	-	7	867	c.397T>G	c.(397-399)Ttc>Gtc	p.F133V	SPOP_ENST00000504102.1_Missense_Mutation_p.F133V|SPOP_ENST00000393328.2_Missense_Mutation_p.F133V|SPOP_ENST00000347630.2_Missense_Mutation_p.F133V|SPOP_ENST00000503676.1_Missense_Mutation_p.F133V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	133	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F133V(4)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AATTTCTTGAATCCCCAGTCT	0.448										Prostate(2;0.17)			39	62	---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13323529	13323529	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr19:13323529C>T	ENST00000360228.5	-	41	5965	c.5966G>A	c.(5965-5967)cGc>cAc	p.R1989H	CACNA1A_ENST00000573710.2_Missense_Mutation_p.R1990H	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1990					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGGCTCCATGCGCTGGAACAT	0.667													8	4	---	---	---	---
ZNF230	7773	broad.mit.edu	37	19	44515050	44515050	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr19:44515050A>G	ENST00000429154.2	+	5	1087	c.859A>G	c.(859-861)Aag>Gag	p.K287E		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				AATATGTGGTAAGAGCTTCTG	0.433													54	63	---	---	---	---
CDH22	64405	broad.mit.edu	37	20	44869670	44869670	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr20:44869670A>C	ENST00000372262.3	-	2	882	c.482T>G	c.(481-483)aTc>aGc	p.I161S	CDH22_ENST00000537909.1_Missense_Mutation_p.I161S	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	161	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				ACTGTCATTGATGTCCTGCAC	0.642													14	74	---	---	---	---
MTG2	26164	broad.mit.edu	37	20	60775813	60775813	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr20:60775813G>A	ENST00000370823.3	+	7	919	c.901G>A	c.(901-903)Gag>Aag	p.E301K	MTG2_ENST00000536470.1_Missense_Mutation_p.E73K|MTG2_ENST00000436421.2_Missense_Mutation_p.E143K	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		CAGGCACATCGAGCGCTGCCG	0.567													119	195	---	---	---	---
TLR8	51311	broad.mit.edu	37	X	12939904	12939904	+	Silent	SNP	T	T	G			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chrX:12939904T>G	ENST00000218032.6	+	2	2832	c.2745T>G	c.(2743-2745)ctT>ctG	p.L915L	TLR8_ENST00000311912.5_Silent_p.L933L	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	915	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ACGTTCTCCTTTGTCTAGAGG	0.443													50	2	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150791530	150791530	+	Silent	SNP	C	C	T			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chrX:150791530C>T	ENST00000370357.4	+	7	785	c.540C>T	c.(538-540)ctC>ctT	p.L180L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	180						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GGACTCAGCTCCTGCAGGTGG	0.527													5	47	---	---	---	---
FOXA1	3169	broad.mit.edu	37	14	38061200	38061202	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chr14:38061200_38061202delCTG	ENST00000250448.2	-	2	848_850	c.787_789delCAG	c.(787-789)cagdel	p.Q263del	FOXA1_ENST00000545425.2_5'UTR|FOXA1_ENST00000540786.1_In_Frame_Del_p.Q230del	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	263					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TGAAGCGCTTCTGGCGGCGCAAG	0.719													13	9	---	---	---	---
MAOA	4128	broad.mit.edu	37	X	43591988	43591988	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KK-A8IK-01A-11D-A364-08	TCGA-KK-A8IK-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	640ab7e7-1e44-444d-b470-196a000a9958	3a8cd4b7-4379-4fcc-b252-6c053077a0d8	g.chrX:43591988delT	ENST00000338702.3	+	9	1121	c.998delT	c.(997-999)attfs	p.I333fs	MAOA_ENST00000542639.1_Frame_Shift_Del_p.I200fs	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	333					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	GATGCTCCAATTTCAATAACC	0.443													65	6	---	---	---	---
