Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample
MIR429	554210	broad.mit.edu	37	1	1104442	1104442	+	RNA	SNP	G	G	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:1104442G>T	ENST00000362106.1	+	0	58					NR_029957.1																						GTCTAATACTGTCTGGTAAAA	0.627													3	36	---	---	---	---
C1QC	714	broad.mit.edu	37	1	22973820	22973820	+	Silent	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:22973820G>A	ENST00000374639.3	+	3	400	c.282G>A	c.(280-282)ggG>ggA	p.G94G	C1QC_ENST00000374640.4_Silent_p.G94G|C1QC_ENST00000374637.1_Silent_p.G94G	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	94	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GACCCCCTGGGATGCCAGGGG	0.627													11	40	---	---	---	---
ASAP3	55616	broad.mit.edu	37	1	23782631	23782631	+	Silent	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:23782631G>A	ENST00000336689.3	-	2	230	c.186C>T	c.(184-186)atC>atT	p.I62I	ASAP3_ENST00000437606.2_Silent_p.I62I|ASAP3_ENST00000449467.2_5'UTR	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	62					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CGGAGCTATGGATTGCCCGCA	0.587													9	28	---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181725150	181725150	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:181725150C>T	ENST00000526775.1	+	28	4156	c.3991C>T	c.(3991-3993)Cgc>Tgc	p.R1331C	CACNA1E_ENST00000367567.4_Missense_Mutation_p.R957C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R1301C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1282C|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R1350C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R1331C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R1350C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1350					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GGAATGGAAGCGCCATGAATT	0.493													4	38	---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197111887	197111887	+	Nonsense_Mutation	SNP	T	T	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:197111887T>A	ENST00000367409.4	-	3	1751	c.1495A>T	c.(1495-1497)Aaa>Taa	p.K499*	ASPM_ENST00000294732.7_Nonsense_Mutation_p.K499*	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	499					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GCCTTCCTTTTAGTAACAGTG	0.358													5	163	---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234536985	234536985	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr1:234536985C>T	ENST00000040877.1	-	25	4012	c.4013G>A	c.(4012-4014)cGc>cAc	p.R1338H	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1338					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CTCCTGAATGCGTTGCCAATT	0.358													6	23	---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141072599	141072599	+	Missense_Mutation	SNP	C	C	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr2:141072599C>A	ENST00000389484.3	-	83	13681	c.12710G>T	c.(12709-12711)tGt>tTt	p.C4237F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4237	EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAACAGTGACACCTCAAATC	0.383										TSP Lung(27;0.18)			4	77	---	---	---	---
YEATS2	55689	broad.mit.edu	37	3	183490196	183490196	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr3:183490196C>T	ENST00000305135.5	+	16	2246	c.2051C>T	c.(2050-2052)tCc>tTc	p.S684F		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	684					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCTTCTGTCTCCAAAGCAGTT	0.537													20	73	---	---	---	---
CNOT6L	246175	broad.mit.edu	37	4	78641641	78641641	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr4:78641641G>C	ENST00000504123.1	-	12	1742	c.1612C>G	c.(1612-1614)Ctc>Gtc	p.L538V	CNOT6L_ENST00000264903.4_Missense_Mutation_p.L538V			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	538					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						GGAGGGTGGAGTTCAAGTTGT	0.527													7	157	---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123237982	123237982	+	Silent	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr4:123237982A>G	ENST00000264501.4	+	62	11008	c.10635A>G	c.(10633-10635)gaA>gaG	p.E3545E	KIAA1109_ENST00000388738.3_Silent_p.E3545E|KIAA1109_ENST00000455637.1_Silent_p.E3545E			Q2LD37	K1109_HUMAN	KIAA1109	3545					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ATATCAGAGAACTGAATGAAC	0.353													4	48	---	---	---	---
HIST1H3B	8358	broad.mit.edu	37	6	26031999	26031999	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr6:26031999C>T	ENST00000244661.2	-	1	289	c.290G>A	c.(289-291)tGt>tAt	p.C97Y		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	97					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						GTAGGCCTCACAAGCCTCCTG	0.577													5	70	---	---	---	---
GSTA3	2940	broad.mit.edu	37	6	52761716	52761716	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr6:52761716G>C	ENST00000211122.3	-	7	622	c.557C>G	c.(556-558)aCc>aGc	p.T186S	GSTA3_ENST00000370968.1_Missense_Mutation_p.T136S	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	186	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	GCTGATTCTGGTTTTCAGGGC	0.517													13	104	---	---	---	---
SNAP91	9892	broad.mit.edu	37	6	84290295	84290295	+	Silent	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr6:84290295A>G	ENST00000428679.2	-	24	2766	c.2173T>C	c.(2173-2175)Ttg>Ctg	p.L725L	SNAP91_ENST00000520302.1_Silent_p.L695L|SNAP91_ENST00000439399.2_Silent_p.L725L|SNAP91_ENST00000195649.6_Silent_p.L720L|SNAP91_ENST00000369694.2_Silent_p.L725L|SNAP91_ENST00000437520.1_Silent_p.L418L|SNAP91_ENST00000521485.1_Silent_p.L720L|SNAP91_ENST00000521743.1_Silent_p.L725L|SNAP91_ENST00000520213.1_Silent_p.L418L			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	725					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GTTGGCATCAAAAGATCACCT	0.433													8	46	---	---	---	---
CEP85L	387119	broad.mit.edu	37	6	118790275	118790275	+	Silent	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr6:118790275C>T	ENST00000368491.3	-	12	2835	c.2214G>A	c.(2212-2214)caG>caA	p.Q738Q	CEP85L_ENST00000368488.5_Silent_p.Q741Q	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	738						centrosome											GCTCCTTGCCCTGAGCACGCT	0.368													10	64	---	---	---	---
PKD1L1	168507	broad.mit.edu	37	7	47944821	47944821	+	Missense_Mutation	SNP	A	A	C			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr7:47944821A>C	ENST00000289672.2	-	11	1674	c.1624T>G	c.(1624-1626)Ttt>Gtt	p.F542V		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	542	PKD 1.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TCCTCTCCAAAATACCACTCA	0.438													20	89	---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48315425	48315425	+	Missense_Mutation	SNP	C	C	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr7:48315425C>A	ENST00000435803.1	+	17	6186	c.6162C>A	c.(6160-6162)aaC>aaA	p.N2054K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2054					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CACCTTACAACTTTGAAGAAC	0.343													4	32	---	---	---	---
COBL	23242	broad.mit.edu	37	7	51096535	51096535	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr7:51096535G>C	ENST00000395542.2	-	12	2688	c.2504C>G	c.(2503-2505)tCt>tGt	p.S835C	COBL_ENST00000265136.7_Missense_Mutation_p.S753C			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	753										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CACAGACGAAGACAGGGAAAT	0.547													18	44	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100681373	100681373	+	Missense_Mutation	SNP	C	C	T	rs144624588		TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr7:100681373C>T	ENST00000306151.4	+	3	6740	c.6676C>T	c.(6676-6678)Cct>Tct	p.P2226S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2226	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P2226T(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACAAGTATGCCTGTCAGCAC	0.502													5	636	---	---	---	---
TG	7038	broad.mit.edu	37	8	134030207	134030207	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr8:134030207G>C	ENST00000220616.4	+	38	6787	c.6747G>C	c.(6745-6747)ttG>ttC	p.L2249F	TG_ENST00000542445.1_Missense_Mutation_p.L619F|TG_ENST00000519543.1_Missense_Mutation_p.L382F|TG_ENST00000522523.1_3'UTR|TG_ENST00000377869.1_Missense_Mutation_p.L2192F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2249					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGAGCCCTTGAACTGGACAG	0.552													14	30	---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8636728	8636728	+	Nonsense_Mutation	SNP	C	C	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr9:8636728C>A	ENST00000381196.4	-	10	724	c.181G>T	c.(181-183)Gga>Tga	p.G61*	PTPRD_ENST00000486161.1_Nonsense_Mutation_p.G61*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.G61*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.G61*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.G61*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.G61*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.G61*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.G61*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.G61*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.G61*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.G61*|PTPRD_ENST00000463477.1_Nonsense_Mutation_p.G61*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	61	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACTTTCTTTCCTTTTTTGTTC	0.453										TSP Lung(15;0.13)			12	109	---	---	---	---
CYLC2	1539	broad.mit.edu	37	9	105767017	105767017	+	Missense_Mutation	SNP	C	C	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr9:105767017C>A	ENST00000374798.3	+	4	291	c.221C>A	c.(220-222)cCa>cAa	p.P74Q	CYLC2_ENST00000487798.1_Missense_Mutation_p.P74Q	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	74	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				CGTAGACAACCATTATGGATG	0.378													17	50	---	---	---	---
EDF1	8721	broad.mit.edu	37	9	139760662	139760662	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr9:139760662G>T	ENST00000371648.4	-	1	56	c.49C>A	c.(49-51)Cct>Act	p.P17T	EDF1_ENST00000224073.1_Missense_Mutation_p.P17T|EDF1_ENST00000371649.1_Missense_Mutation_p.P17T	NM_153200.1	NP_694880.1	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1	17					endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|sequence-specific DNA binding|transcription coactivator activity			lung(1)	1	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GCGGCCGTAGGGCCCTTCTTG	0.731													5	22	---	---	---	---
DOCK1	1793	broad.mit.edu	37	10	129207655	129207655	+	Splice_Site	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr10:129207655G>A	ENST00000280333.6	+	42	4389	c.4280G>A	c.(4279-4281)aGt>aAt	p.S1427N		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1427	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAGATTGTAAGGTAATAATCC	0.448													6	56	---	---	---	---
OR5A1	219982	broad.mit.edu	37	11	59210893	59210893	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr11:59210893G>T	ENST00000302030.2	+	1	277	c.252G>T	c.(250-252)atG>atT	p.M84I		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CTCCCAATATGCTCACTGACT	0.478													5	104	---	---	---	---
C2CD5	9847	broad.mit.edu	37	12	22637658	22637658	+	Missense_Mutation	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr12:22637658A>G	ENST00000333957.4	-	13	1778	c.1523T>C	c.(1522-1524)aTt>aCt	p.I508T	C2CD5_ENST00000446597.1_Missense_Mutation_p.I508T|C2CD5_ENST00000545552.1_Missense_Mutation_p.I521T|C2CD5_ENST00000536386.1_Missense_Mutation_p.I510T|C2CD5_ENST00000542676.1_Missense_Mutation_p.I508T|C2CD5_ENST00000396028.2_Missense_Mutation_p.I499T|C2CD5_ENST00000544930.1_Missense_Mutation_p.I323T	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ACCTTTTCCAATAACTGTTGC	0.383													4	109	---	---	---	---
XPO4	64328	broad.mit.edu	37	13	21373356	21373356	+	Missense_Mutation	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr13:21373356A>G	ENST00000400602.2	-	16	2305	c.2270T>C	c.(2269-2271)tTa>tCa	p.L757S	XPO4_ENST00000255305.6_Missense_Mutation_p.L757S	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	757					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AAAACCTCCTAAGACTAGAGC	0.438													14	364	---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88329858	88329858	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr13:88329858C>T	ENST00000325089.6	+	2	2434	c.2215C>T	c.(2215-2217)Ccc>Tcc	p.P739S	SLITRK5_ENST00000400028.3_Missense_Mutation_p.P498S	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	739						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCCCGCGCTGCCCAAGGTGAA	0.667													19	98	---	---	---	---
MCF2L	23263	broad.mit.edu	37	13	113738343	113738343	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr13:113738343G>T	ENST00000397030.1	+	18	2159	c.2122G>T	c.(2122-2124)Gac>Tac	p.D708Y	MCF2L_ENST00000423482.2_Missense_Mutation_p.D673Y|MCF2L_ENST00000375608.3_Missense_Mutation_p.D705Y|MCF2L_ENST00000375597.4_Missense_Mutation_p.D673Y|MCF2L_ENST00000442652.2_Missense_Mutation_p.D705Y|MCF2L_ENST00000375601.3_Missense_Mutation_p.D679Y|MCF2L_ENST00000434480.2_Missense_Mutation_p.D681Y|MCF2L_ENST00000421756.1_Missense_Mutation_p.D679Y|MCF2L_ENST00000375604.2_Missense_Mutation_p.D732Y|MCF2L_ENST00000535094.2_Missense_Mutation_p.D675Y			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	705	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AAACTACACTGACTGCCCAGA	0.433													4	78	---	---	---	---
CDC16	8881	broad.mit.edu	37	13	115027372	115027372	+	Missense_Mutation	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr13:115027372A>G	ENST00000360383.3	+	15	1523	c.1325A>G	c.(1324-1326)gAc>gGc	p.D442G	CDC16_ENST00000252458.6_Missense_Mutation_p.D297G|CDC16_ENST00000375308.1_Missense_Mutation_p.D348G|CDC16_ENST00000375312.3_Missense_Mutation_p.D297G|CDC16_ENST00000252457.5_Missense_Mutation_p.D441G|CDC16_ENST00000375310.1_Missense_Mutation_p.D348G|CDC16_ENST00000356221.3_Missense_Mutation_p.D442G	NM_001078645.1|NM_003903.3	NP_001072113.1|NP_003894.3	Q13042	CDC16_HUMAN	cell division cycle 16	442					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding			endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			GTAACAGTTGACAAATGGGAA	0.378													5	80	---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72037466	72037466	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr15:72037466G>A	ENST00000355327.3	+	12	2062	c.1928G>A	c.(1927-1929)cGc>cAc	p.R643H	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000261862.6_Missense_Mutation_p.R643H|THSD4_ENST00000357769.4_Missense_Mutation_p.R283H			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	643						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CCTATTTTCCGCTGTGTGCAC	0.542													92	321	---	---	---	---
GOLGA6A	342096	broad.mit.edu	37	15	74368249	74368249	+	Silent	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr15:74368249G>A	ENST00000290438.3	-	8	682	c.642C>T	c.(640-642)caC>caT	p.H214H		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	214										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						CCTGTGTCACGTGTGCGTTCA	0.582													4	134	---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60685506	60685506	+	Silent	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr17:60685506A>G	ENST00000582809.1	+	22	2332	c.1629A>G	c.(1627-1629)gcA>gcG	p.A543A	TLK2_ENST00000346027.5_Silent_p.A692A|TLK2_ENST00000343388.7_Silent_p.A660A|TLK2_ENST00000542523.1_Silent_p.A660A|TLK2_ENST00000326270.9_Silent_p.A714A			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	714	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						CACCTGAAGCAAAGGTAAGTT	0.418													6	33	---	---	---	---
UNC13D	201294	broad.mit.edu	37	17	73827403	73827403	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr17:73827403G>A	ENST00000207549.4	-	26	2853	c.2474C>T	c.(2473-2475)aCa>aTa	p.T825I	UNC13D_ENST00000412096.2_Missense_Mutation_p.T825I	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	825	MHD2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACTGTGAGTGTGTGGGTCCA	0.657									Familial Hemophagocytic Lymphohistiocytosis				13	26	---	---	---	---
PGLYRP2	114770	broad.mit.edu	37	19	15582860	15582860	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr19:15582860C>T	ENST00000292609.4	-	3	1313	c.1184G>A	c.(1183-1185)gGc>gAc	p.G395D	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.G395D			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	395					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CTTCGGGCGGCCCCGATAAGG	0.662													6	38	---	---	---	---
IL17RA	23765	broad.mit.edu	37	22	17586829	17586829	+	Missense_Mutation	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr22:17586829A>G	ENST00000319363.6	+	11	1163	c.1030A>G	c.(1030-1032)Acc>Gcc	p.T344A		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	344					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CGTCTGCATGACCTGGAGGCT	0.572													3	48	---	---	---	---
PIWIL3	440822	broad.mit.edu	37	22	25147435	25147435	+	Silent	SNP	A	A	G			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr22:25147435A>G	ENST00000332271.5	-	9	1424	c.1008T>C	c.(1006-1008)gaT>gaC	p.D336D	PIWIL3_ENST00000527701.1_Silent_p.D227D|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000533313.1_Silent_p.D227D	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	336	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCCAATCAATATCATCTACTC	0.338													43	123	---	---	---	---
FOXR2	139628	broad.mit.edu	37	X	55650284	55650284	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chrX:55650284C>T	ENST00000339140.3	+	1	452	c.140C>T	c.(139-141)gCc>gTc	p.A47V		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	47					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						CAAATCCTTGCCAAATACAGA	0.527													3	34	---	---	---	---
MAGEA10	4109	broad.mit.edu	37	X	151303840	151303840	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chrX:151303840G>T	ENST00000370323.4	-	4	569	c.253C>A	c.(253-255)Cag>Aag	p.Q85K	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Missense_Mutation_p.Q85K	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	85										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCACTCTGGGGAGGATTT	0.542													5	101	---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42024869	42024869	+	Frame_Shift_Del	DEL	T	T	-			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr4:42024869delT	ENST00000264451.7	+	5	629	c.449delT	c.(448-450)cttfs	p.L150fs		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CTAGAACAACTTCGAAAAATC	0.343													28	60	---	---	---	---
HNRNPUL2	221092	broad.mit.edu	37	11	62484484	62484486	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-VP-A879-01A-11D-A34U-08	TCGA-VP-A879-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ff201859-353a-48ec-80f0-4efbd0274515	d19f8f3a-2084-4991-b2d4-e42c6747adc5	g.chr11:62484484_62484486delTTC	ENST00000301785.5	-	11	2148_2150	c.1956_1958delGAA	c.(1954-1959)cagaac>cac	p.652_653QN>H	HNRNPUL2-BSCL2_ENST00000403734.2_In_Frame_Del_p.652_653QN>H	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	652					cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CCGGCTTCGGTTCTGCCGGTTAC	0.557													20	72	---	---	---	---
